TY  - JOUR
A1  - Matkovic, Aleksandar
A1  - Vasic, Borislav
A1  - Pesic, Jelena
A1  - Prinz, Julia
A1  - Bald, Ilko
A1  - Milosavljevic, Aleksandar R.
A1  - Gajic, Rados
T1  - Enhanced structural stability of DNA origami nanostructures by graphene encapsulation
JF  - NEW JOURNAL OF PHYSICS
N2  - We demonstrate that a single-layer graphene replicates the shape of DNA origami nanostructures very well. It can be employed as a protective layer for the enhancement of structural stability of DNA origami nanostructures. Using the AFM based manipulation, we show that the normal force required to damage graphene encapsulated DNA origami nanostructures is over an order of magnitude greater than for the unprotected ones. In addition, we show that graphene encapsulation offers protection to the DNA origami nanostructures against prolonged exposure to deionized water, and multiple immersions. Through these results we demonstrate that graphene encapsulated DNA origami nanostructures are strong enough to sustain various solution phase processing, lithography and transfer steps, thus extending the limits of DNA-mediated bottom-up fabrication.
KW  - graphene
KW  - DNA origami nanostructures
KW  - atomic force microscopy
Y1  - 2016
U6  - https://doi.org/10.1088/1367-2630/18/2/025016
SN  - 1367-2630
VL  - 18
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Rackwitz, Jenny
A1  - Kopyra, Janina
A1  - Dabkowska, Iwona
A1  - Ebel, Kenny
A1  - Rankovic, MiloS Lj.
A1  - Milosavljevic, Aleksandar R.
A1  - Bald, Ilko
T1  - Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - 2-Fluoroadenine ((2F)A) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in (2F)A are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in (2F)A-containing oligonucleotides upon irradiation with LEEs. The incorporation of (2F)A into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by (2F)A at 5.5, 10, and 15 eV are very similar. Thus, (2F)A can be considered an effective radiosensitizer operative at a wide range of electron energies.
KW  - ab initio calculations
KW  - dissociative electron attachment
KW  - DNA origami
KW  - DNA radiation damage
KW  - fludarabine
Y1  - 2016
U6  - https://doi.org/10.1002/anie.201603464
SN  - 1433-7851
SN  - 1521-3773
VL  - 55
SP  - 10248
EP  - 10252
PB  - Wiley-VCH
CY  - Weinheim
ER  -