TY - JOUR A1 - Nishino, Takeshi A1 - Okamoto, Ken A1 - Leimkühler, Silke T1 - Enzymes of the Xanthine Oxidase Family JF - Molybdenum and tungsten enzymes : biochemistry N2 - Enzymes from the xanthine oxidase (XO) family of molybdenum enzymes are generally, with some exceptions, molybdenum iron–sulfur flavin hydroxylases. Mammalian xanthine oxidoreductase and aldehyde oxidase were among the first enzymes to be studied in detail more than 100 years ago and, surprisingly, they continue to be thoroughly studied in molecular detail with many open and unresolved questions remaining. Enzymes of the XO family are characterized by a molybdenum cofactor (Moco) active site with a MoVIOS(OH) ligand sphere where substrate hydroxylation of either aromatic or aliphatic carbon centers is catalyzed. During the reaction, electrons are transferred to the oxidizing substrate, most commonly O2 or NAD+, which react at the FAD site. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 SN - 978-1-78262-881-1 U6 - https://doi.org/10.1039/9781782623915-00192 VL - 5 SP - 192 EP - 239 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Leimkühler, Silke A1 - Lemaire, Olivier N. A1 - Iobbi-Nivol, Chantal T1 - Bacterial Molybdoenzymes BT - Chaperones, Assembly and Insertion JF - Molybdenum and tungsten enzymes : biochemistry N2 - The biogenesis of molybdoenzymes is a cytoplasmic event requiring both the folded apoenzymes and the matured molybdenum cofactor. The structure and the complexity of the molybdenum cofactor varies in each molybdoenzyme family and consequently different accessory proteins are required for the maturation of the respective enzymes. Thus, for enzymes of both the DMSO reductase and xanthine oxidase families, specific chaperones exist which are dedicated to increase the stability and the folding of specific members of each family. In this review, we describe the role of these chaperones for molybdoenzyme maturation. We present a model which describes step by step the mechanism of the maturation of representative molybdoenzymes from each family. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 U6 - https://doi.org/10.1039/9781782623915-00117 VL - 5 SP - 117 EP - 142 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Leimkühler, Silke A1 - Mendel, Ralf-Rainer T1 - Molybdenum Cofactor Biosynthesis JF - Molybdenum and tungsten enzymes: biochemistry N2 - The biosynthesis of the molybdenum cofactor (Moco) is highly conserved among all kingdoms of life. In all molybdoenzymes with the exception of nitrogenase, the molybdenum atom is coordinated to a dithiolene group present in the pterin-based 6-alkyl side chain of molybdopterin (MPT). In general, the biosynthesis of Moco can be divided into three steps in eukaryotes, and four steps in bacteria and archaea: (i) the starting point is the formation of the cyclic pyranopterin monophosphate (cPMP) from 5′GTP, (ii) in the second step the two sulfur molecules are inserted into cPMP leading to the formation of MPT, (iii) in the third step the molybdenum atom is inserted into molybdopterin to form Moco and (iv) additional modification of Moco occurs in bacteria and archaea with the attachment of a nucleotide (CMP or GMP) to the phosphate group of MPT, forming the dinucleotide variants of Moco. This review will focus on the biosynthesis of Moco in bacteria, humans and plants. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 SN - 978-1-78262-881-1 U6 - https://doi.org/10.1039/9781782623915 VL - 5 SP - 100 EP - 116 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Kühne, Franziska A1 - Maas, Jana A1 - Wiesenthal, Sophia A1 - Weck, Florian T1 - Supervision in der Verhaltenstherapie T1 - Supervision in behavioral therapy BT - ein Scoping Review zur Identifikation von Forschungszielen BT - a scoping review for identification of research objectives JF - Zeitschrift für klinische Psychologie und Psychotherapie : Forschung und Praxis N2 - Theoretischer Hintergrund:Supervision spielt eine zentrale Rolle zum Wissens- und Kompetenzerwerb sowie in der Qualitätssicherung. Fragestellung:Ziel war es, den aktuellen Forschungsstand zur Supervision im Rahmen der kognitiven Verhaltenstherapie abzubilden, um daraus Schlussfolgerungen für die zukünftige Forschung abzuleiten. Methode:Zur Evidenzsynthese wurde ein Scoping Review durchgeführt, das die Darstellung zentraler Konzepte, aktueller Evidenz und möglicher Forschungsbedarfe ermöglichte. Neben einer systematischen Literaturrecherche wurden Vorwärts- und Rückwärtssuchstrategien eingesetzt. Ergebnisse:Eingeschlossen wurden zwölf Publikationen basierend auf zehn empirischen Studien. Alle Studien beschrieben Ausbildungssettings, aber nur wenige untersuchten übende Interventionen (z. B. Rollenspiele). Häufig wurden Effekte subjektiv erfasst, die methodische Qualität der Begleitstudien variierte. Schlussfolgerungen:Notwendig sind weitere methodisch hochwertige Studien, experimentell orientiert oder in der klinischen Praxis, die die Supervisionsforschung bereichern können. N2 - Background:Supervision plays a central role for the acquisition of therapeutic knowledge and competence and for quality control. Objective:The study aimed at mapping the current evidence regarding cognitive–behavioral supervision, and drawing conclusions for future research. Method:For evidence synthesis, we conducted a scoping review to outline key concepts, the current evidence, and potential gaps in research. In addition to a systematic literature search, forward and backward search strategies were implemented. Results:We included 12 publications on 10 empirical studies. All studies referred to education and training, but only a few examined exercises (e. g., role plays). Mostly, outcomes were evaluated subjectively, and study quality varied. Conclusion:Further methodologically sound studies, experimentally oriented or in clinical care, may support research. KW - clinical supervision KW - review KW - scoping study KW - cognitive behavioral therapy KW - psychotherapy KW - klinische Supervision KW - Übersichtsarbeit KW - kognitive Verhaltenstheraphie KW - Psychoterapie Y1 - 2017 U6 - https://doi.org/10.1026/1616-3443/a000414 SN - 1616-3443 SN - 2190-6297 VL - 46 IS - 2 SP - 73 EP - 82 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Sander, Martha Maria A1 - Eccard, Jana A1 - Heim, Wieland T1 - Flight range estimation of migrant yellow-browed warblers phylloscopus inornatus on the East Asian flyway JF - Bird study : the journal of the British Trust for Ornithology N2 - Fat loads were quantified for 2125 Yellow-browed Warblers Phylloscopus inornatus trapped at a stop-over site in Far East Russia during autumn migration. Flight ranges of 660-820km were estimated for the fattest individuals, suggesting that they would need to stop for refuelling at least six times to reach their wintering areas in South East Asia. Y1 - 2017 U6 - https://doi.org/10.1080/00063657.2017.1409696 SN - 0006-3657 SN - 1944-6705 VL - 64 SP - 569 EP - 572 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Apelojg, Benjamin ED - Apelojg, Benjamin ED - Banse, Gerhard T1 - Innovationen als Element einer zukunftsweisenden ökonomischen und technischen Bildung JF - Technische Bildung und berufliche Orientierung im Wandel - Rückblicke, Einblicke, Ausblicke N2 - Innovationen sind wie ein Motor, der unser ökonomisches, soziales und ge-sellschaftliches Leben antreibt und laufend verändert. Ob in der Medizin-technik, Luft- und Raumfahrt, Energiegewinnung, im Netz oder in der Schule: In allen Bereichen sorgen Innovationen für die stetige Weiterent-wicklung unser Gesellschaft. Bernd Meier hat die Bedeutung von Innova-tionen und innovativem Denken für die technische Bildung und Schule früh erkannt. Mit einer kurzen Rückschau auf sein Wirken hinsichtlich der Be-deutung von Innovationen für die technische und ökonomische Bildung soll ein wichtiger Bereich seiner Arbeit gewürdigt werden. Zu Beginn wird der Innovationsbegriff allgemein umrissen und dann mit Blick auf Schule präzi-siert. Danach wird dargestellt, welchen Stellenwert die Thematik Innovation und Technologie nicht nur in den Publikationen von Bernd Meier, sondern auch in seinen Lehrkonzeptionen eingenommen hat. Im Anschluss daran wird diskutiert, warum es gerade im Bildungsbereich so schwer ist, innova-tiv zu sein oder dauerhaft Innovationen durchzusetzen.1 Der Beitrag endet mit einem Ausblick, inwiefern Innovationen auch in Zukunft für Schule und das Fach Wirtschaft-Arbeit-Technik (kurz: WAT) eine wichtige Thematik darstellen sollten. Y1 - 2017 SN - 978-3-86464-156-5 VL - 133/134 SP - 95 EP - 107 PB - Trafo-Verlag CY - Berlin ER - TY - JOUR A1 - Apelojg, Benjamin A1 - Bieniok, Majken ED - Fleischer, Lutz ED - Meier, Bernd T1 - Eine Kurzvorstellung der Felix-App und deren Einsatz im PSI-Projekt der Qualitätsoffensive Lehrerbildung JF - Technik und Technologie : Techne cum episteme et commune bonum. Ehrenkolloquium anlässlich des 70. Geburtstages von Gerhard Banse KW - Felix-App KW - Qualitätsoffensive Lehrerbildung KW - Evaluation von Unterricht Y1 - 2017 SN - 978-3-86464-154-1 VL - 131 SP - 223 EP - 234 PB - Trafo-Verlag CY - Berlin ER - TY - JOUR A1 - Arslan, Seçkin A1 - Gür, Eren A1 - Felser, Claudia T1 - Predicting the sources of impaired wh-question comprehension in non-fluent aphasia BT - a cross-linguistic machine learning study on Turkish and German JF - Cognitive neuropsychology N2 - This study investigates the comprehension of wh-questions in individuals with aphasia (IWA) speaking Turkish, a non-wh-movement language, and German, a wh-movement language. We examined six German-speaking and 11 Turkish-speaking IWA using picture-pointing tasks. Findings from our experiments show that the Turkish IWA responded more accurately to both object who and object which questions than to subject questions, while the German IWA performed better for subject which questions than in all other conditions. Using random forest models, a machine learning technique used in tree-structured classification, on the individual data revealed that both the Turkish and German IWA’s response accuracy is largely predicted by the presence of overt and unambiguous case marking. We discuss our results with regard to different theoretical approaches to the comprehension of wh-questions in aphasia. KW - Non-fluent aphasia KW - random forest algorithm KW - sentence comprehension KW - wh-in-situ KW - wh-questions KW - wh-movement Y1 - 2017 U6 - https://doi.org/10.1080/02643294.2017.1394284 SN - 0264-3294 SN - 1464-0627 VL - 34 SP - 312 EP - 331 PB - Taylor & Francis CY - Abingdon ER - TY - BOOK ED - Esguerra, Alejandro ED - Helmerich, Nicole ED - Risse, Thomas T1 - Sustainability Politics and Limited Statehood BT - Contesting the New Modes of Governance Y1 - 2017 SN - 978-3-319-39870-9 SN - 978-3-319-39871-6 U6 - https://doi.org/10.1007/978-3-319-39871-6 PB - Springer CY - Cham ER - TY - JOUR A1 - Reifegerste, Jana A1 - Hauer, Franziska A1 - Felser, Claudia T1 - Agreement processing and attraction errors in aging BT - evidence from subject-verb agreement in German JF - Aging, neuropsychology, and cognition : a journal on normal and dysfunctional development N2 - Effects of aging on lexical processing are well attested, but the picture is less clear for grammatical processing. Where age differences emerge, these are usually ascribed to working-memory (WM) decline. Previous studies on the influence of WM on agreement computation have yielded inconclusive results, and work on aging and subject-verb agreement processing is lacking. In two experiments (Experiment 1: timed grammaticality judgment, Experiment 2: self-paced reading + WM test), we investigated older (OA) and younger (YA) adults’ susceptibility to agreement attraction errors. We found longer reading latencies and judgment reaction times (RTs) for OAs. Further, OAs, particularly those with low WM scores, were more accepting of sentences with attraction errors than YAs. OAs showed longer reading latencies for ungrammatical sentences, again modulated by WM, than YAs. Our results indicate that OAs have greater difficulty blocking intervening nouns from interfering with the computation of agreement dependencies. WM can modulate this effect. KW - Subject-verb agreement KW - attraction errors KW - aging KW - grammaticality judgment KW - self-paced reading Y1 - 2016 U6 - https://doi.org/10.1080/13825585.2016.1251550 SN - 1382-5585 SN - 1744-4128 VL - 24 IS - 6 SP - 672 EP - 702 PB - Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Muwonge, Charles Magoba A1 - Schiefele, Ulrich A1 - Ssenyonga, Joseph A1 - Kibedi, Henry T1 - Self-regulated learning among teacher education students BT - Motivational beliefs influence on the use of metacognition JF - Journal of psychology in Africa N2 - In the present study, we examined the relationships between motivational beliefs (self-efficacy, task value, and control of learning beliefs) and use of metacognitive learning strategies among teacher education students in Uganda. The sample comprised of 649 students selected from seven universities. Data were collected using several scales from the modified Motivated Strategies for Learning Questionnaire, and analysed using Structural Equation Modelling. Task value and self-efficacy independently and significantly predicted students’ reported use of metacognition. Students’ self-reported self-efficacy and task value explained 38% of the variance in their use of metacognition. The evidence suggests interventions aimed at improving teacher education students’ metacognitive skills to focus on enhancing their efficacy and value beliefs. KW - metacognition KW - motivational beliefs KW - motivated strategies for learning questionnaire KW - teacher education students Y1 - 2017 U6 - https://doi.org/10.1080/14330237.2017.1399973 SN - 1433-0237 SN - 1815-5626 VL - 27 IS - 6 SP - 515 EP - 521 PB - Routledge CY - Abingdon ER - TY - JOUR A1 - Pospisil, Christina A1 - Czernitzki, Anna-Franziska A1 - Scheffler, Christiane T1 - No association between nutrition and body height in German kindergarten children BT - a pilot study JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Anthropologists all over the world are discussing influences on individual height including quantity and quality of nutrition. To examine whether a relationship between nutritional components and height can be found this pilot study has been developed. The research samples consisted of 44 children (age 3–6 years) attending two different kindergartens in Germany. Height measurements were taken for each child. Furthermore the parents had to fill out a 24-hour questionnaire to document their children’s eating habits during the weekend. In order to standardize the measured height values z-scores were calculated with reference to the average height of the overall cohort. The results of correlation analysis indicate that height is not significantly related to any of the main nutritional components as protein (r = –0.148), carbohydrates (r = 0.126), fat (r = 0.107), fibre (r = –0.289), vitamin (r = 0.050), calcium (r = 0.110), potassium (r = 0.189) and overall calorie intake (r = 0.302). In conclusion, it can be stated that the quality of nutrition may not have a strong influence on individual height. However, due to the small sample size further research should be provided with a larger cohort of children to verify the present results. KW - nutritional components KW - individual body height KW - children KW - Germany Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0704 SN - 0003-5548 SN - 2363-7099 VL - 74 IS - 3 SP - 199 EP - 202 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Dorani, Maryam A1 - Arvin, Mohsen A1 - Oberhänsli, Roland A1 - Dargahi, Sara T1 - P-T evolution of metapelites from the Bajgan complex in the Makran accretionary prism, south eastern Iran JF - Chemie der Erde : interdisciplinary journal for chemical problems of the geo-sciences and geo-ecology = Geochemistry N2 - The Bajgan Complex, one of the basement constituents of the arc massif in Iranian Makran forms a rugged, deeply incised terrain. The complex consists of pelitic schists with minor psammitic and basic schists, calc silicate rocks, amphibolites, marbles, metavolcanosediments, mafic and felsic intrusives as well as ultramafic rocks. Metapelitic rocks show an amphibolite facies regional metamorphism and contain garnet, biotite, white mica, quartz, albite ± rutile ± apatite. Thermobarometry of garnet schist yields pressure of more than 9 kbar and temperatures between 560 and 675 °C. The geothermal gradient obtained for the peak of regional metamorphism is 19 °C/km, corresponding to a depth of ca. 31 km. Replacement of garnet by chlorite and epidote suggest greenschist facies metamorphism due to a decrease in temperature and pressure through exhumation and retrograde metamorphism (370–450 °C and 3–6 kbar). The metapelitic rocks followed a ‘clockwise’ P–T path during metamorphism, consistent with thermal decline following tectonic thickening. The formation of medium-pressure metamorphic rocks is related to presence of active subduction of the Neotethys Oceanic lithosphere beneath Eurasia in the Makran. KW - Bajgan Complex KW - Makran KW - Metapelitic rock KW - Garnet schist KW - Thermobarometry KW - Clockwise P-T path Y1 - 2017 U6 - https://doi.org/10.1016/j.chemer.2017.07.004 SN - 0009-2819 SN - 1611-5864 VL - 77 IS - 3 SP - 459 EP - 475 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Martykanova, Darina T1 - A Gateway to the World BT - Jewish and Armenian Engineers of Ottoman Background at the Ecole centrale des arts et manufactures (1853-1923) JF - Diasporas : circulations, migrations, histoire N2 - In the second half of the 19th century, the French École centrale des arts et manufactures became one of the engineering schools that enjoyed a worldwide reputation. There were many foreigners among its students. This article focuses on the graduates born in the Ottoman Empire, particularly on Jews and Armenians. It analyses their backgrounds, their common features and their professional careers, tracing their links with other centraliens. The patterns in the Ottoman centraliens’ professional trajectories help us picture a world full of opportunities where highly qualified men could cross borders and build careers with ease, but where, at the same time, origins, allegiances, contacts and credentials mattered greatly. N2 - Dans la seconde moitié du xixe siècle, l’École centrale des arts et manufactures française devint une école d’ingénieurs jouissant d’une réputation internationale ; les étudiants étrangers y furent nombreux. Cet article porte sur les diplômés nés dans l’Empire ottoman, en particuliers les étudiants juifs et arméniens ; il s’attache à leur parcours, à leurs caractéristiques et à leurs carrières professionnelles et restitue leurs liens avec les autres centraliens. L’étude de leurs trajectoires professionnelles permet d’appréhender un monde riche en opportunités, où des hommes hautement qualifiés pouvaient aisément traverser les frontières et construire une carrière, mais où, dans le même temps, les origines, les réseaux d’allégeance, les relations et les diplômes jouent un rôle de premier plan. KW - Engineers KW - Jews KW - Armenians KW - Ottomans KW - Ecole centrale des arts et manufactures KW - networks KW - Ottoman Empire KW - France KW - transnational Y1 - 2017 U6 - https://doi.org/10.4000/diasporas.718 SN - 1637-5823 SN - 2431-1472 VL - 29 SP - 33 EP - 51 PB - Presses Universitaires du Midi CY - Toulouse ER - TY - JFULL T1 - Editorial Board T2 - Public management review Y1 - 2017 U6 - https://doi.org/10.1080/14719037.2017.1367563 SN - 1471-9037 SN - 1471-9045 VL - 19 IS - 10 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Herbst - Voeth, Uta A1 - Dotan, Hilla A1 - Stöhr, Sina T1 - Negotiating with work friends BT - examining gender differences in team negotiations JF - The journal of business & industrial marketing N2 - Purpose - This study aims to investigate whether a team of females negotiates differently than a team of males, and whether (workplace) friendship moderates the relationship between single-gender team composition and negotiation outcomes. Design/methodology/approach - The authors used two laboratory studies and paired 216 MBA students into single-gender teams of friends and non-friends, and then engaged them in several dyadic multi-issue negotiations. Findings - The results show that on average, male teams of non-friends reached significantly better outcomes than female teams of non-friends. However, and interestingly, female teams of friends perform equally to male teams of friends. Research limitations/implications - The authors contribute both to the negotiations and the workplace friendship literature because very little research has examined negotiation among friends at work and in particular team negotiations. In addition, the authors also contribute to the literature on gender differences in negotiations because existing research has rarely examined the differences between all-male and all-female teams and especially the relationship between same-sex teams and their effects on negotiation outcomes. Practical implications - This research has clear implications to managers with regard to team composition. Specifically, a winning all-female team should not be changed! Originality/value - This is the first study to examine the relationship between workplace friendship, gender and negotiation outcomes. KW - Multi-issue negotiation KW - Negotiation performance KW - Gender effects KW - Intra-team friendship KW - Team negotiations KW - Workplace friendships Y1 - 2017 U6 - https://doi.org/10.1108/JBIM-12-2015-0250 SN - 0885-8624 SN - 2052-1189 VL - 32 SP - 558 EP - 566 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Preuss, Melanie A1 - van der Wijst, Per T1 - A phase-specific analysis of negotiation styles JF - The journal of business & industrial marketing N2 - Purpose - The purpose of this study is to analyze whether negotiators stick to one single negotiation style or whether their styles vary during the negotiation process. The paper seeks to identify different combinations of phase-specific negotiation styles and investigates the relationship between these combinations and negotiation performance and satisfaction. Design/methodology/approach - The study is based on a large online negotiation simulation that allows a phase-specific analysis of negotiation styles via an elaborate coding scheme. Findings - The findings reveal that negotiators generally do not limit themselves to a single negotiation style. Instead, they vary their style in the course of different negotiation phases. The authors distinguish between five distinct phase-specific negotiation style patterns that differ with regard to their impact on negotiation performance but not negotiation satisfaction. Practical implications - Negotiation practitioners get to know different phase-specific negotiation style patterns and get insights into which pattern is the most promising for negotiation performance. As a result, they can acquire this phase-specific negotiation style pattern to enhance their performance. Originality/value - The paper contributes to existing negotiation style literature, because it is the first to analyze negotiation styles from a phase-specific point of view. KW - Business-to-business marketing KW - Negotiation performance KW - Negotiation phases KW - Negotiation satisfaction KW - Negotiation styles Y1 - 2017 U6 - https://doi.org/10.1108/JBIM-01-2016-0010 SN - 0885-8624 SN - 2052-1189 VL - 32 IS - 4 SP - 505 EP - 518 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Schmidt, Marco F. A1 - Korb, Oliver A1 - Abell, Chris T1 - Antagonists of the miRNA-Argonaute 2 Protein Complex BT - Anti-miR-AGOs JF - Drug Target miRNA: Methods and Protocols N2 - microRNAs (miRNAs) have been identified as high-value drug targets. A widely applied strategy in miRNA inhibition is the use of antisense agents. However, it has been shown that oligonucleotides are poorly cell permeable because of their complex chemical structure and due to their negatively charged backbone. Consequently, the general application of oligonucleotides in therapy is limited. Since miRNAs’ functions are executed exclusively by the Argonaute 2 protein, we therefore describe a protocol for the design of a novel miRNA inhibitor class: antagonists of the miRNA-Argonaute 2 protein complex, so-called anti-miR-AGOs, that not only block the crucial binding site of the target miRNA but also bind to the protein’s active site. Due to their lower molecular weight and, thus, more drug-like chemical structure, the novel inhibitor class may show better pharmacokinetic properties than reported oligonucleotide inhibitors, enabling them for potential therapeutic use. KW - Drug design KW - microRNA KW - miRNA-Argonaute 2 protein complex KW - miRNA inhibitors KW - miRNA seed region Y1 - 2016 SN - 978-1-4939-6563-2 SN - 978-1-4939-6561-8 SN - 978-1-4939-8236-3 U6 - https://doi.org/10.1007/978-1-4939-6563-2_17 SN - 1064-3745 SN - 1940-6029 VL - 1517 SP - 239 EP - 249 PB - Springer CY - New York ER - TY - JOUR A1 - Zou, Jie A1 - Wang, Weiwei A1 - Neffe, Axel T. A1 - Xu, Xun A1 - Li, Zhengdong A1 - Deng, Zijun A1 - Sun, Xianlei A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Adipogenic differentiation of human adipose derived mesenchymal stem cells in 3D architectured gelatin based hydrogels (ArcGel) JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Polymeric matrices mimicking multiple functions of the ECM are expected to enable a material induced regeneration of tissues. Here, we investigated the adipogenic differentiation of human adipose derived mesenchymal stem cells (hADSCs) in a 3D architectured gelatin based hydrogel (ArcGel) prepared from gelatin and L-lysine diisocyanate ethyl ester (LDI) in an one-step process, in which the formation of an open porous morphology and the chemical network formation were integrated. The ArcGel was designed to support adipose tissue regeneration with its 3D porous structure, high cell biocompatibility, and mechanical properties compatible with human subcutaneous adipose tissue. The ArcGel could support initial cell adhesion and survival of hADSCs. Under static culture condition, the cells could migrate into the inner part of the scaffold with a depth of 840 +/- 120 mu m after 4 days, and distributed in the whole scaffold (2mm in thickness) within 14 days. The cells proliferated in the scaffold and the fold increase of cell number after 7 days of culture was 2.55 +/- 0.08. The apoptotic rate of hADSCs in the scaffold was similar to that of cells maintained on tissue culture plates. When cultured in adipogenic induction medium, the hADSCs in the scaffold differentiated into adipocytes with a high efficiency (93 +/- 1%). Conclusively, this gelatin based 3D scaffold presented high cell compatibility for hADSC cultivation and differentiation, which could serve as a potential implant material in clinical applications for adipose tissue reparation and regeneration. KW - Mesenchymal stem cells KW - gelatin based scaffold KW - adipose tissue regeneration KW - adipogenic differentiation Y1 - 2017 U6 - https://doi.org/10.3233/CH-179210 SN - 1386-0291 SN - 1875-8622 VL - 67 IS - 3-4 SP - 297 EP - 307 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Vasiliev, Sergey B. A1 - Tarchanov, Nikolaj Nikolaevič T1 - Construction of series of perfect lattices by layer superposition JF - Journal of Siberian Federal University : Mathematics & physics JF - Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Serija Matematika i fizika = Mathematics & physics N2 - We construct a new series of perfect lattices in n dimensions by the layer superposition method of Delaunay-Barnes. KW - lattice packing and covering KW - polyhedra and polytopes KW - regular figures KW - division of spaces Y1 - 2017 U6 - https://doi.org/10.17516/1997-1397-2017-10-3-353-361 SN - 1997-1397 SN - 2313-6022 VL - 10 IS - 3 SP - 353 EP - 361 PB - Sibirskij Federalʹnyj Universitet CY - Krasnojarsk ER - TY - JOUR A1 - Boxell, Oliver A1 - Felser, Claudia A1 - Cunnings, Ian T1 - Antecedent contained deletions in native and non-native sentence processing JF - Linguistic approaches to bilingualism N2 - We report the results from an eye-movement monitoring study investigating native (L1) and non-native (L2) speakers’ real-time processing of antecedent-contained deletion (ACD), a type of verb phrase ellipsis in which the ellipsis gap forms part of its own antecedent. The resulting interpretation problem is traditionally thought to be solved by quantifier raising, a covert scope-shifting operation that serves to remove the gap from within its antecedent. Our L2 group comprised advanced, native German-speaking L2 learners of English. The analysis of the eye-movement data showed that both L1 and L2 English speakers tried to recover the missing verb phrase after encountering the gap. Only the native speakers showed evidence of ellipsis resolution being affected by quantification, however. No effects of quantification following gap detection were found in the L2 group, by contrast, indicating that recovery of the elided material was accomplished independently from the object’s quantificational status in this group. KW - L2 processing KW - eye-movement monitoring KW - antecedent contained deletion Y1 - 2016 U6 - https://doi.org/10.1075/lab.15006.box SN - 1879-9264 SN - 1879-9272 VL - 7 IS - 5 SP - 554 EP - 582 PB - John Benjamins Publishing Co. CY - Amsterdam ER - TY - JOUR A1 - Mah, Dana-Kristin A1 - Ifenthaler, Dirk T1 - Academic staff perspectives on first-year students’ academic competencies JF - Journal of applied research in higher education : JARHE N2 - Purpose: The purpose of this paper is to examine the expectations, perceptions and role understanding of academic staff using a model of academic competencies (i.e. time management, learning skills, technology proficiency, self-monitoring and research skills). Design/methodology/approach: Semi-structured interviews were conducted with ten members of academic staff at a German university. Participants’ responses to the open-ended questions were coded inductively, while responses concerning the proposed model of academic competencies were coded deductively using a priori categories. Findings: Participating academic staff expected first-year students to be most competent in time management and in learning skills; they perceived students’ technology proficiency to be rather high but their research skills as low. Interviews indicated a mismatch between academic staff expectations and perceptions. Practical implications: These findings may enable universities to provide support services for first-year students to help them to adjust to the demands of higher education. They may also serve as a platform to discuss how academic staff can support students to develop the required academic competencies, as well as a broader conversation about higher education pedagogy and competency assessment. Originality/value: Little research has investigated the perspectives of academic staff concerning the academic competencies they expect of first-year students. Understanding their perspectives is crucial for improving the quality of institutions; their input into the design of effective support services is essential, as is a constructive dialogue to identify strategies to enhance student retention. KW - Expectations KW - Support KW - First-year experience KW - Academic competencies KW - Academic staff perspectives Y1 - 2017 U6 - https://doi.org/10.1108/JARHE-03-2017-0023 SN - 2050-7003 SN - 1758-1184 VL - 9 IS - 4 SP - 630 EP - 640 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Arantzeta, Miren A1 - Bastiaanse, Roelien A1 - Burchert, Frank A1 - Wieling, Martijn Benjamin A1 - Martinez-Zabaleta, Maite A1 - Laka, Itziar T1 - Eye-tracking the effect of word order in sentence comprehension in aphasia BT - evidence from Basque, a free word order ergative language JF - Language, cognition and neuroscience N2 - Agrammatic speakers of languages with overt grammatical case show impaired use of the morphological cues to establish theta-role relations in sentences presented in non-canonical word orders. We analysed the effect of word order on the sentence comprehension of aphasic speakers of Basque, an ergative, free word order and head-final (SOV) language. Ergative languages such as Basque establish a one-to-one mapping of the thematic role and the case marker. We collected behavioural and gaze-fixation data while agrammatic speakers performed a picture-matching task with auditorily presented sentences with different word orders. We found that people with aphasia (PWA) had difficulties in assigning theta-roles in Theme-Agent order. This result is in line with processing accounts. Contrary to previous findings, our data do not suggest a systematic delay in the integration of morphological information in the PWA group, but strong reliance on the ergative case morphology and difficulties assigning thematic roles into the determiner phrases. KW - Aphasia KW - comprehension KW - Basque KW - sentence processing KW - eye-tracking Y1 - 2017 U6 - https://doi.org/10.1080/23273798.2017.1344715 SN - 2327-3798 SN - 2327-3801 VL - 32 IS - 10 SP - 1320 EP - 1343 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Lu, Yong-Ping A1 - Hasan, Ahmed A. A1 - Zeng, Shufei A1 - Hocher, Berthold T1 - Plasma ET-1 concentrations are elevated in pregnant women with hypertension - meta-analysis of clinical studies JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. Methods: Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects model. Results: Sixteen published cohort studies including 1739 hypertensive cases and 409 controls were used in the meta-analysis. ET-1 plasma concentrations were higher in hypertensive pregnant women as compared to the controls (mean difference between groups: 19.02 [15.60～22.44], P < 0.00001,). These finding were driven by severity of hypertension and/or degree of proteinuria. Conclusion: Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure. KW - Et-1 KW - Pregnancy KW - Hypertension KW - Meta-analysis Y1 - 2017 U6 - https://doi.org/10.1159/000482004 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 4 SP - 654 EP - 663 PB - Karger CY - Basel ER - TY - JOUR A1 - Dahlke, Sandro A1 - Maturilli, Marion T1 - Contribution of atmospheric advection to the amplified winter warming in the arctic north atlantic region JF - Advances in meteorology N2 - Arctic Amplification of climate warming is caused by various feedback processes in the atmosphere-ocean-ice system and yields the strongest temperature increase during winter in the Arctic North Atlantic region. In our study, we attempt to quantify the advective contribution to the observed atmospheric warming in the Svalbard area. Based on radiosonde measurements from Ny-Ålesund, a strong dependence of the tropospheric temperature on the synoptic flow direction is revealed. Using FLEXTRA backward trajectories, an increase of advection from the lower latitude Atlantic region towards Ny-Ålesund is found that is attributed to a change in atmospheric circulation patterns. We find that about one-quarter (0.45 K per decade) of the observed atmospheric winter near surface warming trend in the North Atlantic region of the Arctic (2 K per decade) is due to increased advection of warm and moist air from the lower latitude Atlantic region, affecting the entire troposphere. Y1 - 2017 U6 - https://doi.org/10.1155/2017/4928620 SN - 1687-9309 SN - 1687-9317 PB - Hindawi Publ. Corp. CY - New York ER - TY - GEN A1 - Loupos, Konstantinos A1 - Damigos, Yannis A1 - Amditis, Angelos A1 - Gerhard, Reimund A1 - Rychkov, Dmitry A1 - Wirges, Werner A1 - Schulze, Manuel A1 - Lenas, Sotiris-Angelos A1 - Chatziandreoglou, Christos A1 - Malliou, Christina A1 - Tsaoussidis, Vassilis A1 - Brady, Ken A1 - Frankenstein, Bernd T1 - Structural health monitoring system for bridges based on skin-like sensor T2 - IOP conference series : Materials science and engineering N2 - Structural health monitoring activities are of primal importance for managing transport infrastructure, however most SHM methodologies are based on point-based sensors that have limitations in terms of their spatial positioning requirements, cost of development and measurement range. This paper describes the progress on the SENSKIN EC project whose objective is to develop a dielectric-elastomer and micro-electronics-based sensor, formed from a large highly extensible capacitance sensing membrane supported by advanced microelectronic circuitry, for monitoring transport infrastructure bridges. Such a sensor could provide spatial measurements of strain in excess of 10%. The actual sensor along with the data acquisition module, the communication module and power electronics are all integrated into a compact unit, the SENSKIN device, which is energy-efficient, requires simple signal processing and it is easy to install over various surface types. In terms of communication, SENSKIN devices interact with each other to form the SENSKIN system; a fully distributed and autonomous wireless sensor network that is able to self-monitor. SENSKIN system utilizes Delay-/Disruption-Tolerant Networking technologies to ensure that the strain measurements will be received by the base station even under extreme conditions where normal communications are disrupted. This paper describes the architecture of the SENSKIN system and the development and testing of the first SENSKIN prototype sensor, the data acquisition system, and the communication system. Y1 - 2017 U6 - https://doi.org/10.1088/1757-899X/236/1/012100 SN - 1757-8981 VL - 236 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Gebser, Martin A1 - Maratea, Marco A1 - Ricca, Francesco T1 - The sixth answer set programming competition JF - Journal of artificial intelligence research : JAIR N2 - Answer Set Programming (ASP) is a well-known paradigm of declarative programming with roots in logic programming and non-monotonic reasoning. Similar to other closely related problemsolving technologies, such as SAT/SMT, QBF, Planning and Scheduling, advancements in ASP solving are assessed in competition events. In this paper, we report about the design and results of the Sixth ASP Competition, which was jointly organized by the University of Calabria (Italy), Aalto University (Finland), and the University of Genoa (Italy), in affiliation with the 13th International Conference on Logic Programming and Non-Monotonic Reasoning. This edition maintained some of the design decisions introduced in 2014, e.g., the conception of sub-tracks, the scoring scheme,and the adherence to a fixed modeling language in order to push the adoption of the ASP-Core-2 standard. On the other hand, it featured also some novelties, like a benchmark selection stage classifying instances according to their empirical hardness, and a “Marathon” track where the topperforming systems are given more time for solving hard benchmarks. Y1 - 2017 U6 - https://doi.org/10.1613/jair.5373 SN - 1076-9757 SN - 1943-5037 VL - 60 SP - 41 EP - 95 PB - AI Access Found. CY - Marina del Rey ER - TY - JOUR A1 - Li, Zhengdong A1 - Xu, Xun A1 - Wang, Weiwei A1 - Kratz, Karl A1 - Sun, Xianlei A1 - Zou, Jie A1 - Deng, Zijun A1 - Jung, Friedrich Wilhelm A1 - Gossen, Manfred A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells. KW - Mesenchymal stem cells KW - precondition KW - microstructure KW - migration KW - FAK-MAPK Y1 - 2017 U6 - https://doi.org/10.3233/CH-179208 SN - 1386-0291 SN - 1875-8622 VL - 67 SP - 267 EP - 278 PB - IOS Press CY - Amsterdam ER - TY - BOOK A1 - Apelojg, Benjamin A1 - Banse, Gerhard ED - Apelojg, Benjamin ED - Banse, Gerhard T1 - Technische Bildung und berufliche Orientierung im Wandel BT - Rückblicke, Einblicke, Ausblicke T3 - Sammelband N2 - Der Band versammelt 21 Beiträge, die unter dem Titel "Technische Bildung und berufliche Orientierung im Wandel" aus Anlass der Emeritierung von Prof. Dr. paed. habil Bernd Meier, Professur für Technologie und Berufliche Orientierung an der Wirtschafts- und Sozialwissenschaftlichen Fakultät der Universität Potsdam, auf einem Kolloquium 2017 gehalten wurden. KW - Technische Bildung KW - Wirtschaft, Arbeit, Technik Y1 - 2017 SN - 978-3864641565 VL - 133/134 PB - Trafo CY - Berlin ER - TY - JFULL ED - Carlà-Uhink, Filippo ED - Lindner, Martin T1 - Imagines BT - classical receptions in the visual and performing arts N2 - This series seeks to broaden the scholarly community’s understanding of the reception of classical antiquity in the visual and performing arts. A particular focus will be drawn on the 20th and 21st centuries and on media that have been traditionally neglected because considered “commercial” and/or “popular”, such as comics, advertising, digital media, design, fashion, and theme parks. It challenges traditional, and still very widespread, assumptions that distinguish “high” from “popular” culture, but also demonstrates the indisputable importance that classical antiquity enjoys in the modern and postmodern world, and all across the planet, carefully looking at forms of Classical Receptions outside the “traditional” regions object of such studies. Through a consistent shift from the traditional, academic approach, the series is the product of a continuous dialogue between scholars on the one side, and “producers” of classical reception – painters, sculptors, photographs, architects, designers, etc. –on the other, who write about their mechanisms of appropriation of the Ancient world . Each book highlights the popularity of antiquity today and reveals the forms and mechanisms of its reception. The series thus explains the choice of subjects and motives, the elaboration and re-mediatization processes taking place in the creative act, as well as the complexity of the “reception chains”, which make it today impossible, for instance, to visualize the ancient world without the filter of historical movies. Y1 - 2017 PB - Bloomsbury Academic CY - London ER - TY - JOUR A1 - Toy, Virginia Gail A1 - Sutherland, Rupert A1 - Townend, John A1 - Allen, Michael J. A1 - Becroft, Leeza A1 - Boles, Austin A1 - Boulton, Carolyn A1 - Carpenter, Brett A1 - Cooper, Alan A1 - Cox, Simon C. A1 - Daube, Christopher A1 - Faulkner, D. R. A1 - Halfpenny, Angela A1 - Kato, Naoki A1 - Keys, Stephen A1 - Kirilova, Martina A1 - Kometani, Yusuke A1 - Little, Timothy A1 - Mariani, Elisabetta A1 - Melosh, Benjamin A1 - Menzies, Catriona D. A1 - Morales, Luiz A1 - Morgan, Chance A1 - Mori, Hiroshi A1 - Niemeijer, Andre A1 - Norris, Richard A1 - Prior, David A1 - Sauer, Katrina A1 - Schleicher, Anja Maria A1 - Shigematsu, Norio A1 - Teagle, Damon A. H. A1 - Tobin, Harold A1 - Valdez, Robert A1 - Williams, Jack A1 - Yeo, Samantha A1 - Baratin, Laura-May A1 - Barth, Nicolas A1 - Benson, Adrian A1 - Boese, Carolin A1 - Célérier, Bernard A1 - Chamberlain, Calum J. A1 - Conze, Ronald A1 - Coussens, Jamie A1 - Craw, Lisa A1 - Doan, Mai-Linh A1 - Eccles, Jennifer A1 - Grieve, Jason A1 - Grochowski, Julia A1 - Gulley, Anton A1 - Howarth, Jamie A1 - Jacobs, Katrina A1 - Janku-Capova, Lucie A1 - Jeppson, Tamara A1 - Langridge, Robert A1 - Mallyon, Deirdre A1 - Marx, Ray A1 - Massiot, Cécile A1 - Mathewson, Loren A1 - Moore, Josephine A1 - Nishikawa, Osamu A1 - Pooley, Brent A1 - Pyne, Alex A1 - Savage, Martha K. A1 - Schmitt, Doug A1 - Taylor-Offord, Sam A1 - Upton, Phaedra A1 - Weaver, Konrad C. A1 - Wiersberg, Thomas A1 - Zimmer, Martin T1 - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand JF - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG N2 - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled. KW - Alpine Fault KW - New Zealand KW - scientific drilling KW - mylonite KW - cataclasite Y1 - 2017 U6 - https://doi.org/10.1080/00288306.2017.1375533 SN - 0028-8306 SN - 1175-8791 VL - 60 IS - 4 SP - 497 EP - 518 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Fayyaz, Susann A1 - Japtok, Lukasz A1 - Schumacher, Fabian A1 - Wigger, Dominik A1 - Schulz, Tim Julius A1 - Haubold, Kathrin A1 - Gulbins, Erich A1 - Völler, Heinz A1 - Kleuser, Burkhard T1 - Lysophosphatidic acid inhibits insulin signaling in primary rat hepatocytes via the LPA(3) receptor subtype and is increased in obesity JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology N2 - Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX). ATX converts lysophosphatidylcholine to lysophosphatidic acid (LPA) and acts as the main producer of extracellular LPA. This bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA receptors (LPA1-6). Methods: The activation of phosphatidylinositide 3-kinases (PI3K) signaling (Akt and GSK-3ß) was analyzed via western blotting in primary rat hepatocytes. Incorporation of glucose into glycogen was measured by using radio labeled glucose. Real-time PCR analysis and pharmacological modulation of LPA receptors were performed. Human plasma LPA levels of obese (BMI > 30, n = 18) and normal weight individuals (BMI 18.5-25, n = 14) were analyzed by liquid chromatography tandem-mass spectrometry (LC-MS/MS). Results: Pretreatment of primary hepatocytes with LPA resulted in an inhibition of insulin-mediated Gck expression, PI3K activation and glycogen synthesis. Pharmacological approaches revealed that the LPA3-receptor subtype is responsible for the inhibitory effect of LPA on insulin signaling. Moreover, human plasma LPA concentrations (16: 0 LPA) of obese participants (BMI > 30) are significantly elevated in comparison to normal weight individuals (BMI 18.5-25). Conclusion: LPA is able to interrupt insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype. Moreover, the bioactive lipid LPA (16: 0) is increased in obesity. KW - Lysophosphatidic acid KW - Insulin signaling KW - Adipose tissue KW - Autotaxin KW - Hepatic insulin resistance KW - LPA(3) receptor subtype Y1 - 2017 U6 - https://doi.org/10.1159/000480470 SN - 1015-8987 SN - 1421-9778 VL - 43 SP - 445 EP - 456 PB - Karger CY - Basel ER - TY - GEN A1 - Nguyen, Vu Hoa A1 - Richert, S. A1 - Park, Hyunji A1 - Böker, Alexander A1 - Schnakenberg, Uwe T1 - Single interdigital transducer as surface acoustic wave impedance sensor T2 - Biosensors N2 - Surface acoustic wave (SAW) devices are well-known for gravimetric sensor applications. In biosensing applications, chemical-and biochemically evoked adsorption processes at surfaces are detected in liquid environments using delay-line or resonator sensor configurations, preferably in combination with appropriate microfluidic devices. In this paper, a novel SAW-based impedance sensor type is introduced which uses only one interdigital electrode transducer (IDT) simultaneously as SAW generator and sensor element. It is shown that the amplitude of the reflected S-11 signal directly depends on the input impedance of the SAW device. The input impedance is strongly influenced by mass adsorption which causes a characteristic and measurable impedance mismatch. KW - SAW impedance sensor KW - microfluidic KW - PHEMA Y1 - 2017 U6 - https://doi.org/10.1016/j.protcy.2017.04.032 SN - 2212-0173 VL - 27 SP - 70 EP - 71 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hess, Markus A1 - Wirtz, Susanne A1 - Allroggen, Marc A1 - Scheithauer, Herbert T1 - Intervention und Therapie für Täter und Opfer von Schulbullying BT - ein systematisches Review BT - a systematic review JF - Praxis der Kinderpsychologie und Kinderpsychiatrie : Ergebnisse aus Psychotherapie, Beratung und Psychiatrie N2 - Bullying ist eine Form wiederholten, aggressiven Verhaltens mit ernstzunehmenden Auswirkungen, unter denen Täter und Opfer häufig lange nach Ende des Bullying-Geschehens leiden. Dennoch ist die Therapie von Bullying und den damit einhergehenden Folgen ein bisher in der Forschung vernachlässigtes Thema. Im Rahmen eines systematischen Literaturüberblicks wurde daher untersucht, welche Therapieformen zur Behandlung von Bullying und dessen Folgen bei Opfern und bei Tätern bereits angewendet wurden. Eine systematische Suche in nationalen und internationalen Datenbanken führte zu 31 relevanten Publikationen, in denen 34 therapeutische Interventionen aus über 14 Ländern beschrieben wurden. In zehn Therapiestudien mit kontrolliertem Design zeigte sich, dass Behandlungsangebote, die sich sowohl an die betroffenen Personen als auch an ihr soziales Umfeld richten, besonders effektiv in der Behandlung von Bullying-Folgen sind. Die restlichen 24 Behandlungsansätze wurden keiner kontrollierten Evaluation unterzogen. Insgesamt zwei Drittel aller therapeutischen Interventionen wenden sich an die Gruppe der Opfer. Hier wird im Unterschied zur Behandlung von Tätern verstärkt auf Gruppentherapien zurückgegriffen. Unter der Bandbreite an Ansätzen ist die kognitive Verhaltenstherapie am häufigsten vertreten. Festzustellen bleibt ein Forschungsmangel an evidenzbasierten, gezielten Interventionen zur Behandlung von Bullying und dessen Folgen bei Opfern und Tätern. Unseres Wissens stellt diese Arbeit den ersten systematischen Überblick zu therapeutischen Interventionen bei Bullying für Kinder und Jugendliche dar. T2 - Intervention and Therapy for Perpetrators and Victims of Bullying KW - therapy KW - intervention KW - perpetrator KW - victim KW - bullying KW - Therapie KW - Intervention KW - Täter KW - Opfer Y1 - 2017 U6 - https://doi.org/10.13109/prkk.2017.66.10.740 SN - 0032-7034 SN - 2196-8225 VL - 66 IS - 10 SP - 740 EP - 755 PB - Vandenhoeck & Ruprecht CY - Göttingen ER - TY - GEN A1 - Schmidt-Hattenberger, Cornelia A1 - Bergmann, Peter A1 - Labitzke, Tim A1 - Pommerencke, Julia A1 - Rippe, Dennis A1 - Wagner, Florian A1 - Wiese, Bernd T1 - Monitoring the complete life-cycle of a CO2 storage reservoir-Demonstration of applicability of geoelectrical imaging T2 - 13th International Conference on Greenhouse Gas Control Technologies (GHGT) N2 - In this paper, the applicability of deep downhole geoelectrical monitoring for detecting CO2 related signatures is evaluated after a nearly ten year period of CO2 storage at the Ketzin pilot site. Deep downhole electrode arrays have been studied as part of a multi-physical monitoring concept at four CO2 pilot test sites worldwide so far. For these sites, it was considered important to implement the geoelectrical method into the measurement program of tracking the CO2 plume. Analyzing the example of the Ketzin site, it can be seen that during all phases of the CO2 storage reservoir development the resistivity measurements and their corresponding tomographic interpretation contribute in a beneficial manner to the measurement, monitoring and verification (MMV) protocol. The most important impact of a permanent electrode array is its potential as tool for estimating reservoir saturations. KW - Geoeletrical imaging KW - permanent downhole electrode array KW - CO2 storage monitoring Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.03.1526 SN - 1876-6102 VL - 114 SP - 3948 EP - 3955 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Al-Ani, Ayad T1 - CPS and the Worker BT - Reorientation and Requalification? JF - Industrial Internet of Things : Cybermanufacturing Systems N2 - The idea of interlinked, sensor-augmented, self-governing Cyber Physical System (CPS) production processes is gaining momentum. At the same time, the impact of this concept on the workforce remains surprisingly vague. This can be explained by the fact that man is not at the centre of these developments and—even more importantly—automation is geared towards eliminating human activity. Based on the first views in the 1980s, the label of the “process worker” assumed an almost exclusive focus on control and maintenance tasks for this new type of worker in the automated factory. Recent experiences show, however, that as long as robots are not self-learning, man will be the template for these machines and we can already notice the emerging parallelism of fully automated production lines and human workshops. The changing nature of the workforce will gain further momentum if one depicts new, open formats of production. Here, the worker will have to assume new roles in reconfiguring the production processes. Y1 - 2016 SN - 978-3-319-42559-7 SN - 978-3-319-42558-0 U6 - https://doi.org/10.1007/978-3-319-42559-7_23 SN - 2365-4139 SP - 563 EP - 574 PB - Springer CY - Cham ER - TY - JOUR A1 - Neuber, Corinna A1 - Schumacher, Fabian A1 - Gulbins, Erich A1 - Kleuser, Burkhard T1 - Mass Spectrometric Determination of Fatty Aldehydes Exemplified by Monitoring the Oxidative Degradation of (2E)-Hexadecenal in HepG2 Cell Lysates JF - Lipidomics N2 - Within the last few decades, liquid chromatography-mass spectrometry (LC-MS) has become a preferred method for manifold issues in analytical biosciences, given its high selectivity and sensitivity. However, the analysis of fatty aldehydes, which are important components of cell metabolism, remains challenging. Usually, chemical derivatization prior to MS detection is required to enhance ionization efficiency. In this regard, the coupling of fatty aldehydes to hydrazines like 2,4-dinitrophenylhydrazine (DNPH) is a common approach. Additionally, hydrazones readily react with fatty aldehydes to form stable derivatives, which can be easily separated using high-performance liquid chromatography (HPLC) and subsequently detected by MS. Here, we exemplarily present the quantification of the long-chain fatty aldehyde (2E)-hexadecenal, a break-down product of the bioactive lipid sphingosine 1-phosphate (S1P), after derivatization with 2-diphenylacetyl-1,3-indandione-1-hydrazone (DAIH) via isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight (ESI-QTOF) MS. Moreover, we show that the addition of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) as a coupling agent allows for simultaneous determination of fatty aldehydes and fatty acids as DAIH derivatives. Taking advantage of this, we describe in detail how to monitor the degradation of (2E)-hexadecenal and the concurrent formation of its oxidation product (2E)-hexadecenoic acid in lysates of human hepatoblastoma (HepG2) cells within this chapter. KW - (2E)-hexadecenal KW - (2E)-hexadecenoic acid KW - Sphingosine 1-phosphate KW - Derivatization KW - DAIH KW - EDC KW - Isotope-dilution KW - HPLC-ESI-QTOF Y1 - 2017 SN - 978-1-4939-6946-3 SN - 978-1-4939-6944-9 U6 - https://doi.org/10.1007/978-1-4939-6946-3_10 SN - 0893-2336 SN - 1940-6045 VL - 125 SP - 147 EP - 158 PB - Humana Press CY - Totowa ER - TY - JOUR A1 - Czernitzki, Anna-Franziska A1 - Pospisil, Christina A1 - Musalek, Martin A1 - Mumm, Rebekka A1 - Scheffler, Christiane T1 - Analysis of longitudinal data of height z-scores in kindergarten children BT - a pilot study JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Changes in body height throughout extended historic periods are very complex and dynamic processes. Thispilot study aimed to investigate the pattern of longitudinal height z-scores changes in children before and after entering kindergarten. In summer 2016, we measured height and weight of 32 children from 4 groups of two kindergartens aged 3–6 years. All ages were centered according to the age of entry into the kindergarten. For each child we determined mean z-scores for height before and after entering the kindergarten, and assessed the variances for each kindergarten group. Twenty-two children targeted in height z-scores towards average height of their respective kindergarten group, 10 children did not. Due to the small numbers, the convergence in height variance however, remained insignificant (chi-squared independence test, p = 0.127). Additional studies with larger sample sizes are needed to confirm this pilot study. KW - Height z-score KW - kindergarten children KW - secular trend KW - strategic growth adjustment KW - social signal Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0708 SN - 0003-5548 VL - 74 IS - 2 SP - 109 EP - 112 PB - Schweizerbart science publishers CY - Stuttgart ER - TY - JOUR A1 - Schwiebs, Anja A1 - Thomas, Dominique Jeanette A1 - Kleuser, Burkhard A1 - Pfeilschifter, Josef A1 - Radeke, Heinfried H. T1 - Nuclear translocation of SGPP-1 and decrease of SGPL-1 activity contribute to sphingolipid rheostat regulation of inflammatory dendritic cells JF - Mediators of inflammation N2 - A balanced sphingolipid rheostat is indispensable for dendritic cell function and survival and thus initiation of an immune response. Sphingolipid levels are dynamically maintained by the action of sphingolipid enzymes of which sphingosine kinases, S1P phosphatases (SGPP-1/2) and S1P lyase (SGPL-1), are pivotal in the balance of S1P and sphingosine levels. In this study, we present that SGPP-1 and SGPL-1 are regulated in inflammatory dendritic cells and contribute to S1P fate. TLR-dependent activation caused SGPL-1 protein downregulation with subsequent decrease of enzymatic activity by two-thirds. In parallel, confocal fluorescence microscopy revealed that endogenous SGPP-1 was expressed in nuclei of naive dendritic cells and was translocated into the cytoplasmatic compartment upon inflammatory stimulation resulting in dephosphorylation of S1P. Mass spectrometric determination showed that a part of the resulting sphingosine was released from the cell, increasing extracellular levels. Another route of diminishing intracellular S1P was possibly taken by its export via ATP-binding cassette transporter C1 which was upregulated in array analysis, while the S1P transporter, spinster homolog 2, was not relevant in dendritic cells. These investigations newly describe the sequential expression and localization of the endogenous S1P regulators SGPP-1 and SGPL-1 and highlight their contribution to the sphingolipid rheostat in inflammation. Y1 - 2017 U6 - https://doi.org/10.1155/2017/5187368 SN - 0962-9351 SN - 1466-1861 PB - Hindawi Publishing Corp. CY - London ER - TY - JOUR A1 - Yue, Jinxing A1 - Alter, Kai-Uwe A1 - Howard, David A1 - Bastiaanse, Roelien T1 - Early access to lexical-level phonological representations of Mandarin word-forms BT - evidence from auditory N1 habituation JF - Language, cognition and neuroscience N2 - An auditory habituation design was used to investigate whether lexical-level phonological representations in the brain can be rapidly accessed after the onset of a spoken word. We studied the N1 component of the auditory event-related electrical potential, and measured the amplitude decrements of N1 associated with the repetition of a monosyllabic tone word and an acoustically similar pseudo-word in Mandarin Chinese. Effects related to the contrastive onset consonants were controlled for by introducing two control words. We show that repeated pseudo-words consistently elicit greater amplitude decrements in N1 than real words. Furthermore, this lexicality effect is free from sensory fatigue or rapid learning of the pseudo-word. These results suggest that a lexical-level phonological representation of a spoken word can be accessed as early as 110ms after the onset of the word-form. KW - Auditory N1 KW - short-term habituation KW - spoken word KW - Mandarin Chinese KW - language KW - event-related potential KW - lexical access Y1 - 2017 U6 - https://doi.org/10.1080/23273798.2017.1290261 SN - 2327-3798 SN - 2327-3801 VL - 32 IS - 9 SP - 1148 EP - 1163 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - You, Zewang A1 - Behl, Marc A1 - Löwenberg, Candy A1 - Lendlein, Andreas T1 - pH-sensitivity and conformation change of the n-terminal methacrylated peptide VK20 JF - MRS advances : a journal of the Materials Research Society (MRS) N2 - N-terminal methacrylation of peptide MAXI, which is capable of conformational changes variation of the pH, results in a peptide, named VK20. Increasing the reactivity of this terminal group enables further coupling reactions or chemical modifications of the peptidc. However, this end group functionalization may influence the ability of confonnational changes of VK20; as well as its properties. In this paper; the influence of pH on the transition between random coil and beta-sheet conformation of VK20; including the transition kinetics, were investigated. At pH values of 9 and higher, the kinetics beta-sheet formation increased tor VK(2 0, compared to MAXI. The self-assembly into beta-sheets recognized by the formation of a physically crosslinked gel was furthermore indicated by a significant increase of G. An increase in pH (from 9 to 9.5) led to a faster gelation of the peptide VK20. Simultaneously, G was increased from 460 +/- 70 Pa (at pH 9) to 1520 +/- 180 Pa (at pH 9.5). At the nanoscale, the gel showed a highly interconnected fibrillar/network structure with uniform fibril widths of approximately 3.4 +/- 0.5 nm (N=30). The recovery of the peptide conformation back to random coil resulted in the dissolution of the gel; whereby the kinetics of the recovery depended on the pH. Conclusively, the ability of MAXI to undergo confommtional changes was not affected by N-terminal methacrylation whereas the kinetics of pH-sensitive beta-sheet formations has been increased. Y1 - 2017 U6 - https://doi.org/10.1557/adv.2017.491 SN - 2059-8521 VL - 2 SP - 2571 EP - 2579 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Muthaura, Charles N. A1 - Keriko, Joseph M. A1 - Mutai, Charles A1 - Yenesew, Abiy A1 - Heydenreich, Matthias A1 - Atilaw, Yoseph A1 - Gathirwa, Jeremiah W. A1 - Irungu, Beatrice N. A1 - Derese, Solomon T1 - Antiplasmodial, cytotoxicity and phytochemical constituents of four maytenus species used in traditional medicine in Kenya JF - The natural products journal N2 - Background: In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity. Objective: To isolate antiplasmodial compounds from these plant species which could be used as marker compounds in the standardization of their extracts as a phytomedicine for malaria. Methods: Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy. Results: Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed promising antiplasmodial activity with IC50, 3.63 and 3.95 ng/ml against chloroquine sensitive (D6) and resistant (W2) P. falciparum, respectively and moderate cytotoxicity (CC50, 37.5 ng/ml) against Vero E6 cells. The other compounds showed weak antiplasmodial (IC50 > 1.93 mu g/ml) and cytotoxic (CC50 > 39.52 mu g/ml) activities against P. falciparum and Vero E6 cells, respectively. Conclusion: (20 alpha)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methyl-ester (pristimerin) (1) was the most active marker and lead compound that warrants further investigation as a template for the development of new antimalarial drugs. Pristimerin is reported for the first time in M. putterlickioides. 3-Hydroxyolean-12-en-28-oic acid (oleanolic acid) (5), stigmast-5-en-3-ol (beta-sitosterol) (6), 3-oxo-28-friedelanoic acid (7), olean-12-en-3-ol (beta-amyrin) (8), lup-20(29)-en-3-ol (lupeol) (9) and lup-20(29)-en-3-one (lupenone) (10) are reported for the first time in M. undata. KW - Antimalarial plants KW - antiplasmodial KW - cytotoxicity KW - marker compound KW - Maytenus spp. KW - phytomedicine KW - pristimerin Y1 - 2017 U6 - https://doi.org/10.2174/2210315507666161206144050 SN - 2210-3155 SN - 2210-3163 VL - 7 IS - 2 SP - 144 EP - 152 PB - Bentham Science Publ. CY - Sharjah ER - TY - JOUR A1 - Fyndanis, Valantis A1 - Lind, Marianne A1 - Varlokosta, Spyridoula A1 - Kambanaros, Maria A1 - Soroli, Efstathia A1 - Ceder, Klaudia A1 - Grohmann, Kleanthes K. A1 - Rofes, Adrià A1 - Simonsen, Hanne Gram A1 - Bjekić, Jovana A1 - Gavarró, Anna A1 - Kraljević, Jelena Kuvač A1 - Martínez-Ferreiro, Silvia A1 - Munarriz, Amaia A1 - Pourquie, Marie A1 - Vuksanović, Jasmina A1 - Zakariás, Lilla A1 - Howard, David T1 - Cross-linguistic adaptations of The Comprehensive Aphasia Test BT - challenges and solutions JF - Clinical linguistics & phonetics N2 - Comparative research on aphasia and aphasia rehabilitation is challenged by the lack of comparable assessment tools across different languages. In English, a large array of tools is available, while in most other languages, the selection is more limited. Importantly, assessment tools are often simple translations and do not take into consideration specific linguistic and psycholinguistic parameters of the target languages. As a first step in meeting the needs for comparable assessment tools, the Comprehensive Aphasia Test is currently being adapted into a number of languages spoken in Europe. In this article, some key challenges encountered in the adaptation process and the solutions to ensure that the resulting assessment tools are linguistically and culturally equivalent, are proposed. Specifically, we focus on challenges and solutions related to the use of imageability, frequency, word length, spelling-to-sound regularity and sentence length and complexity as underlying properties in the selection of the testing material. KW - Aphasia KW - assessment KW - Comprehensive Aphasia Test (CAT) KW - cross-linguistic adaptations KW - outcome measures Y1 - 2017 U6 - https://doi.org/10.1080/02699206.2017.1310299 SN - 0269-9206 SN - 1464-5076 VL - 31 IS - 7-9 SP - 697 EP - 710 PB - Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Chang, Der-Chen A1 - Hedayat Mahmoudi, Mahdi A1 - Schulze, Bert-Wolfgang T1 - Singular degenerate operators JF - Applicable analysis : an international journal N2 - We outline some simplified and more general method for constructing parametrices on higher singular spaces. We also outline basic ideas on operators on manifolds with conical or edge singularities. KW - Operators on singular cones KW - Mellin symbols with values in the edge calculus KW - parametrices of elliptic operators Y1 - 2017 U6 - https://doi.org/10.1080/00036811.2017.1336546 SN - 0003-6811 SN - 1563-504X VL - 96 IS - 14 SP - 2434 EP - 2456 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Balta Beylergil, Sinem A1 - Beck, Anne A1 - Deserno, Lorenz A1 - Lorenz, Robert C. A1 - Rapp, Michael A. A1 - Schlagenhauf, Florian A1 - Heinz, Andreas A1 - Obermayer, Klaus T1 - Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence JF - NeuroImage: Clinical : a journal of diseases affecting the nervous system N2 - Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the “double-update” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward. KW - Alcohol dependence KW - Prediction error KW - Reinforcement learning KW - Reversal learning KW - Dorsolateral prefrontal cortex KW - Decision-making Y1 - 2017 U6 - https://doi.org/10.1016/j.nicl.2017.04.010 SN - 2213-1582 VL - 15 SP - 80 EP - 94 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kaufmann, Yvonne Marie A1 - Maiwald, Lisa Marie A1 - Schindler, Svenja A1 - Weck, Florian T1 - Wie wirkt sich mehrmaliges Kompetenz-Feedback auf psychotherapeutische Behandlungen aus? T1 - How does multiple competence feedback affect psychotherapeutic treatment? BT - eine qualitative Analyse BT - a qualitative analysis JF - Zeitschrift für klinische Psychologie und Psychotherapie : Forschung und Praxis N2 - Theoretischer Hintergrund: Einflüsse von therapeutenorientiertem Kompetenz-Feedback in der Psychotherapieausbildung wurden bislang wenig untersucht. Fragestellung: Wie gehen Ausbildungstherapeuten mit Feedback um? Welchen Einfluss hat ein regelmäßiges Kompetenz-Feedback auf die Qualität psychotherapeutischer Behandlungen (insbesondere Therapiesitzungen, therapeutische Beziehung, Person des Therapeuten, Supervision)? Methode: Elf Therapeuten wurden mithilfe eines halbstrukturierten Interviewleitfadens befragt. Die Auswertung erfolgte mittels qualitativer Inhaltsanalyse nach Mayring (2015). Ergebnisse: Das auf Basis der Interviews erstellte Kategoriensystem umfasste die Kategorien „Erwartungen an das Feedback“, „Wahrnehmung des Feedbacks“, „Verarbeitung von und Umgang mit Feedback“, „Folgen, Auswirkungen und Veränderungen durch Feedback“ sowie „Verbesserungswünsche“. Schlussfolgerungen: Therapeuten streben eine Umsetzung des Feedbacks an, welches sich auf die Behandlung, die Supervision, die eigene Person und die therapeutische Beziehung auswirkt. N2 - Background: To date, the influence of therapist-oriented feedback in psychotherapy training has rarely been investigated. Objective: How do therapists in training deal with competence feedback? What influence does a regular competence feedback have on treatment quality (especially therapy sessions, therapeutic alliance, the therapist, supervision)? Method: We interviewed 11 therapists using a semistructured interview guide. The text material was analyzed with qualitative content analysis (Mayring, 2015). Results: The interview-based system of categories consists of: expectations toward feedback; perception of feedback; processing of feedback; consequences, effects, and changes due to feedback; and suggestions for improvement. Conclusion: Therapists strive to implement feedback. Competence feedback has an impact on treatment, supervision, the therapist, and the therapeutic alliance. KW - feedback KW - psychotherapy training KW - psychotherapeutic competencies KW - qualitative content analysis KW - clinical supervision Y1 - 2017 U6 - https://doi.org/10.1026/1616-3443/a000412 SN - 1616-3443 SN - 2190-6297 VL - 46 IS - 2 SP - 96 EP - 106 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Peng, Xingzhou A1 - Behl, Marc A1 - Zhang, Pengfei A1 - Mazurek-Budzyńska, Magdalena A1 - Feng, Yakai A1 - Lendlein, Andreas T1 - Synthesis and characterization of multiblock poly(ester-amide-urethane)s JF - MRS advances : a journal of the Materials Research Society (MRS) N2 - In this study, a multiblock copolymer containing oligo(3-methyl-morpholine-2, 5-dione) (oMMD) and oligo(3-sec-butyl-morpholine-2, 5-dione) (oBMD) building blocks obtained by ring-opening polymerization (ROP) of the corresponding monomers, was synthesized in a polyaddition reaction using an aliphatic diisocyanate. The multiblock copolymer (pBMD-MMD) provided a molecular weight of 40, 000 g·mol−1, determined by gel permeation chromatography (GPC). Incorporation of both oligodepsipeptide segments in multiblock copolymers was confirmed by 1H NMR and Matrix Assisted Laser Desorption/Ionization Time Of Flight Mass Spectroscopy (MALDI-TOF MS) analysis. pBMD-MMD showed two separated glass transition temperatures (61 °C and 74 °C) indicating a microphase separation. Furthermore, a broad glass transition was observed by DMTA, which can be attributed to strong physical interaction i.e. by H-bonds formed between amide, ester, and urethane groups of the investigated copolymers. The obtained multiblock copolymer is supposed to own the capability to exhibit strong physical interactions. Y1 - 2017 U6 - https://doi.org/10.1557/adv.2017.486 SN - 2059-8521 VL - 2 SP - 2551 EP - 2559 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Buschhüter, David A1 - Spoden, Christian A1 - Borowski, Andreas T1 - Physics knowledge of first semester physics students in Germany BT - a comparison of 1978 and 2013 cohorts JF - International journal of science education N2 - Over the last decades, the percentage of the age group choosing to pursue university studies has increased significantly across the world. At the same time, there are university teachers who believe that the standards have fallen. There is little research on whether students nowadays demonstrate knowledge or abilities similar to that of the preceding cohorts. However, in times of educational expansion, empirical evidence on student test performance is extremely helpful in evaluating how well educational systems cope with the increasing numbers of students. In this study, we compared a sample of 2322 physics freshmen from 2013 with another sample of 2718 physics freshmen from 1978 at universities in Germany with regard to their physics knowledge based on their results in the same entrance test. Previous results on mathematics knowledge and abilities in the same sample of students indicated that there was no severe decline in their average achievement. This paper compares the physics knowledge of the same two samples of students. Contrary to their mathematics results, their physics results showed a substantial decrease in physics knowledge as measured by the test. KW - University physics KW - entrance test KW - generational comparison Y1 - 2017 U6 - https://doi.org/10.1080/09500693.2017.1318457 SN - 0950-0693 SN - 1464-5289 VL - 39 IS - 9 SP - 1109 EP - 1132 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Yılmaz, Zafer T1 - The AKP and the spirit of the ‘new’ Turkey BT - imagined victim, reactionary mood, and resentful sovereign JF - Turkish studies N2 - A strong sense of victimhood, a discourse of social suffering, and complementary bodily performances, which mobilize rancor, resentfulness, and revengefulness, are fundamental elements of Turkish-Islamist ideology. This article discusses the political dynamics and implications of such assertions of victimhood in the Turkish context. To underscore these dynamics, it analyses the role of the logic of pain in the subject formation of Turkish-Islamist identity and how this logic has been revitalized by constitutive and hegemonic social imagination, and circulated and intensified by a reactionary mood. Additionally, it aims to expose how this reactionary mood profoundly depends on contradictory subjectification processes, which simultaneously involve mobilization of feelings of impotency, non-responsibility, self-pitying, and sublimation of power. This subject formation opens the way for identification with authoritarian figures in the Turkish case. KW - Justice and Development Party (AKP) KW - victimhood KW - resentment KW - reactionary mood KW - Turkish-Islamist ideology Y1 - 2017 U6 - https://doi.org/10.1080/14683849.2017.1314763 SN - 1468-3849 SN - 1743-9663 VL - 18 IS - 3 SP - 482 EP - 513 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Muschalla, Beate T1 - Work-anxiety-coping intervention improves work-coping perception while a recreational intervention leads to deterioration BT - results from a randomized controlled trial JF - European journal of work and organizational psychology : the official journal of The European Association of Work and Organizational Psychology N2 - Work-anxieties are costly and need early intervention. The perception of being able to cope with work is a basic requirement for work ability. This randomized controlled trial investigates whether a cognitive behavioural, work-anxiety-coping group (WAG) intervention leads to better work-coping perception than an unspecific recreational group (RG). Heterogeneous people in medical rehabilitation, who were due to return to work, were interviewed concerning their work-anxieties, and either randomly assigned to a WAG (n=85) or a RG (n=95). The participants (with an average of 50years old [range 23-64]; 51% women; 70% workers or employees, 25% academics, 5% unskilled) followed the group intervention for four or six sessions. The perceived work-coping was assessed by self-rating (Inventory for Job-Coping and Return Intention JoCoRi) after each group session. Although participants had a slight temporary decrease in work-coping after group session two (from M-1=2.47 to M-2=2.28, d(Cohen)=-.22), the WAG led to the improvement of perceived work-coping over the intervention course (from M-1=2.47 to M-6=2.65, d(Cohen)=.18). In contrast, participants from the RG reported lower work-coping after six group sessions (from M-1=2.26 to M-6=2.02, d(Cohen)=-.18). It is considered that people with work-anxieties need training in work-coping. By focusing on recreation only, this may lead to deterioration of work-coping. Indeed, intervention designers should be aware of temporary deterioration (side effects) when confronting participants with work-coping. KW - Work-anxiety KW - work-coping KW - return to work KW - intervention KW - mental health Y1 - 2017 U6 - https://doi.org/10.1080/1359432X.2017.1384378 SN - 1359-432X SN - 1464-0643 VL - 26 IS - 6 SP - 858 EP - 869 PB - Taylor & Francis CY - Abingdon ER -