TY - JOUR A1 - Hortobagyi, Tibor A1 - Granacher, Urs A1 - Fernandez-del-Olmo, Miguel A1 - Howatson, Glyn A1 - Manca, Andrea A1 - Deriu, Franca A1 - Taube, Wolfgang A1 - Gruber, Markus A1 - Marquez, Gonzalo A1 - Lundbye-Jensen, Jesper A1 - Colomer-Poveda, David T1 - Functional relevance of resistance training-induced neuroplasticity in health and disease JF - Neuroscience & biobehavioral reviews : official journal of the International Behavioral Neuroscience Society N2 - Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few weeks, i.e., resistance training, can substantially increase maximal voluntary force in the practiced task and can also increase gross motor performance. The increase in motor performance is often accompanied by neuroplastic adaptations in the central nervous system. While historical data assigned functional relevance to such adaptations induced by resistance training, this claim has not yet been systematically and critically examined in the context of motor performance across the lifespan in health and disease. A review of muscle activation, brain and peripheral nerve stimulation, and imaging data revealed that increases in motor performance and neuroplasticity tend to be uncoupled, making a mechanistic link between neuroplasticity and motor performance inconclusive. We recommend new approaches, including causal mediation analytical and hypothesis-driven models to substantiate the functional relevance of resistance training-induced neuroplasticity in the improvements of gross motor function across the lifespan in health and disease. KW - Maximal voluntary contraction (MVC) KW - strength training KW - Electromyography (EMG) KW - Transcranial magnetic brain stimulation (TMS) KW - Electroencephalography (EEG) KW - Functional magnetic resonance imaging (fMRI) KW - athletic performance KW - aging KW - Parkinson's disease KW - Multiple sclerosis KW - stroke KW - directed acyclic graphs KW - causal mediation analysis Y1 - 2020 U6 - https://doi.org/10.1016/j.neubiorev.2020.12.019 SN - 0149-7634 SN - 1873-7528 VL - 122 SP - 79 EP - 91 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Rossi, Sonja A1 - Telkemeyer, Silke A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth T1 - Shedding light on words and sentences near-infrared spectroscopy in language research JF - Brain & language : a journal of the neurobiology of language N2 - Investigating the neuronal network underlying language processing may contribute to a better understanding of how the brain masters this complex cognitive function with surprising ease and how language is acquired at a fast pace in infancy. Modern neuroimaging methods permit to visualize the evolvement and the function of the language network. The present paper focuses on a specific methodology, functional near-infrared spectroscopy (fNIRS), providing an overview over studies on auditory language processing and acquisition. The methodology detects oxygenation changes elicited by functional activation of the cerebral cortex. The main advantages for research on auditory language processing and its development during infancy are an undemanding application, the lack of instrumental noise, and its potential to simultaneously register electrophysiological responses. Also it constitutes an innovative approach for studying developmental issues in infants and children. The review will focus on studies on word and sentence processing including research in infants and adults. KW - Language KW - Language acquisition KW - Word processing KW - Sentence processing KW - Lateralization KW - Optical imaging (OI) KW - Near-infrared spectroscopy (NIRS) KW - Electroencephalography (EEG) Y1 - 2012 U6 - https://doi.org/10.1016/j.bandl.2011.03.008 SN - 0093-934X VL - 121 IS - 2 SP - 152 EP - 163 PB - Elsevier CY - San Diego ER -