TY - JOUR A1 - Fürst, Dieter Oswald A1 - Gautel, Mathias T1 - The anatomy of a molecular giant : how the sarcomere cytoskeleton is assembled from immunoglobulin superfamily molecules ; invited review Y1 - 1995 ER - TY - JOUR A1 - Obermann, Wolfgang A1 - Plessmann, Uwe A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - Purification and biochemical characterization of myomesin, a myosin and titin binding protein, from bovine skeletal muscle Y1 - 1995 ER - TY - JOUR A1 - VanDerLoop, Frank T. L. A1 - VanDerVen, Peter F. M A1 - Fürst, Dieter Oswald A1 - Gautel, Mathias A1 - VanEys, Guillaume A1 - Ramaekers, Frans C. S. T1 - Integration of titin into the sarcomeres of cultured differentiating human skeletal muscle cells Y1 - 1996 ER - TY - JOUR A1 - Obermann, Wolfgang A1 - Gautel, Mathias A1 - Steiner, F. A1 - VanDerVen, Peter F. M. A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - The structure of the sarcomeric M band : localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy Y1 - 1996 ER - TY - JOUR A1 - VanDerVen, Peter F. M A1 - Obermann, Wolfgang A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - Myomesin, M-protein and the structure of the sarcomeric M-band Y1 - 1996 ER - TY - JOUR A1 - Gautel, Mathias A1 - Goulding, David A1 - Bullard, Bellinda A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers Y1 - 1996 ER - TY - JOUR A1 - VanDerVen, Peter F. M A1 - Fürst, Dieter Oswald T1 - Assembly of titin, myomesin and M-protein into the sarcomeric M-band in differentiating human skeletal muscle cells in vitro Y1 - 1997 ER - TY - JOUR A1 - Giebing, Thomas A1 - Obermann, Wolfgang A1 - Fürst, Dieter Oswald A1 - D'Haese, Jochen T1 - C-terminally deleted fragments of 40-kDa earthworm actin modulator still shows gelsolin activities Y1 - 1997 ER - TY - JOUR A1 - Obermann, Wolfgang A1 - Gautel, Mathias A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - Molecular structure of the sarcomeric M-band : identification of a novel PKA phosphorylation site and mapping of titin- and myosin-binding domains in myomesin Y1 - 1997 ER - TY - JOUR A1 - Rohwedel, Jürgen A1 - Guan, Kaomei A1 - Zuschratter, W. A1 - Ahnert-Hilger, Shan Jin Gudrun A1 - Fürst, Dieter Oswald A1 - Fässler, Reinhard A1 - Wobus, Anna T1 - Loss of beta 1 integrin function influences the differentiation of embryonic stem cells into the myogenic and neurogenic lineage Y1 - 1998 ER - TY - JOUR A1 - Mayans, Olga A1 - VanDerVen, Peter F. M A1 - Wilmanns, Matthias A1 - Mues, Alexander A1 - Young, Paul A1 - Fürst, Dieter Oswald A1 - Wilmanns, Matthias A1 - Gautel, Mathias T1 - The structural basis of the activation of the serine kinase domain of the giant muscle protein titin during myofibrillogenesis Y1 - 1998 ER - TY - JOUR A1 - VanDerVen, Peter F. M A1 - Fürst, Dieter Oswald T1 - Expression of sarcomeric proteins and assembly of myofibrils in the putative myofibroblast cell line BHK-21/C13 Y1 - 1998 ER - TY - JOUR A1 - Speel, Ernst J. M. A1 - VanDerVen, Peter F. M. A1 - Albrechts, Jozefa C. M. A1 - Hopman, Anton H. N. A1 - Fürst, Dieter Oswald T1 - Chromosomal assignment of the human myomesin gene Y1 - 1998 ER - TY - JOUR A1 - Steiner, F. A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - Structure and expression of the gene encoding murine M-protein, a sarcomere-specific member of the immunoglobulin superfamily Y1 - 1998 ER - TY - JOUR A1 - Gautel, Mathias A1 - Fürst, Dieter Oswald A1 - Cocco, Alessandra A1 - Schiaffino, Stefano T1 - Isoform transitions of the myosin-binding protein C family in developing human and mouse muscles : lack of isoform transcomplementation in cardiac muscle Y1 - 1998 ER - TY - JOUR A1 - Obermann, Wolfgang A1 - VanDerVen, Peter F. M A1 - Steiner, F. A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - Mapping of a myosin binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M-band Y1 - 1998 ER - TY - JOUR A1 - Mues, Alexander A1 - VanDerVen, Peter F. M A1 - Young, Paul A1 - Fürst, Dieter Oswald A1 - Gautel, Mathias T1 - Two immunoglobulin-like domains of the Z-disk portion of titin interact in a conformation-dependent way with telethonin Y1 - 1998 ER - TY - JOUR A1 - Speel, Ernst J. M. A1 - VanDerVen, Peter F. M. A1 - Albrechts, Jozefa C. M. A1 - Ramaekers, Frans C. S. A1 - Fürst, Dieter Oswald A1 - Hopman, Anton H. N. T1 - Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32 Y1 - 1998 ER - TY - JOUR A1 - Bennett, Pauline A1 - Fürst, Dieter Oswald A1 - Gautel, Mathias T1 - The C-protein (myosin binding protein C) family : regulators of contraction and sarcomere function? Y1 - 1999 ER - TY - JOUR A1 - Steiner, F. A1 - Fürst, Dieter Oswald A1 - Weber, Klaus T1 - M-band proteins myomesin und skelemin are encoded by a single gene: analysis of its organization and expression Y1 - 1999 ER - TY - JOUR A1 - Perriard, Jean-Claude A1 - Fürst, Dieter Oswald T1 - Myomesin and M-Protein Y1 - 1999 ER - TY - JOUR A1 - Fürst, Dieter Oswald A1 - Obermann, Wolfgang A1 - VanDerVen, Peter F. M T1 - Structure and assembly of the sarcomeric M-band Y1 - 1999 ER - TY - JOUR A1 - Fürst, Dieter Oswald T1 - Titin, ein molekularer Gigant regiert im quergestreiften Muskel Y1 - 1999 ER - TY - JOUR A1 - Schröder, Rolf A1 - Warlo, Irene A1 - Herrmann, Harald A1 - VanDerVen, Peter F. M A1 - Klasen, Christian A1 - Blümke, Ingmar A1 - Mundegar, Rustam R. A1 - Fürst, Dieter Oswald A1 - Göbel, Hans H. A1 - Magin, Thomas T1 - Immunogold EM reveals a close association of plectin and the desmin cytoskeleton in human skeletal muscle Y1 - 1999 ER - TY - JOUR A1 - VanDerVen, Peter F. M. A1 - Speel, Ernst J. M. A1 - Albrechts, Jozefa C. M. A1 - Ramaekers, Frans C. S. A1 - Hopman, Anton H. N. A1 - Fürst, Dieter Oswald T1 - Chromosomal assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3 Y1 - 1999 ER - TY - JOUR A1 - Guan, Kaomei A1 - Fürst, Dieter Oswald A1 - Wobus, Anna T1 - Modulation of sarcomere assembly during embryonic stem cell-derived cardiomycyte differentiation. Y1 - 1999 ER - TY - JOUR A1 - VanDerVen, Peter A1 - Ehler, Elisabeth A1 - Perriard, Jean-Claude A1 - Fürst, Dieter Oswald T1 - Thick filament assembly occurs after the formation of a cytoskeletal scaffold. Y1 - 1999 ER - TY - JOUR A1 - VanDerVen, Peter F. M. A1 - Speel, Ernst J. M. A1 - Albrechts, Jozefa C. M. A1 - Ramaekers, Frans C. S. A1 - Hopman, Anton H. N. A1 - Fürst, Dieter Oswald T1 - Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3 Y1 - 1999 ER - TY - JOUR A1 - Chakharova, Christina A1 - Wehnert, Manfred A1 - Uhl, K. A1 - Sekthivel, S. A1 - Vorsberg, Hans-Peter A1 - Fürst, Dieter Oswald T1 - Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family Y1 - 2000 ER - TY - JOUR A1 - Wiesner, Sebastian A1 - Salmikangas, Paula A1 - Auerbach, Daniel A1 - Himmel, Mirko A1 - Kempa, Stefan A1 - Hayes, Kathrin A1 - Pacholsky, Dirk A1 - Taivainen, Anu A1 - Schröder, Rolf A1 - Carpen, Olli A1 - Fürst, Dieter Oswald T1 - Indications for a novel muscular dystrophy pathway : gamma-filamin, the muscle-specific filamin isoform, intgeracts with myotilin Y1 - 2000 ER - TY - JOUR A1 - Schröder, Rolf A1 - VanDerVen, Peter F. M. A1 - Warlo, Irene A1 - Schumann, H. A1 - Fürst, Dieter Oswald A1 - Blümke, Ingmar A1 - Goebel, Hans H. A1 - Schmidt, M. C. A1 - Hatzfeld, Mechthild T1 - A member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle Y1 - 2000 ER - TY - JOUR A1 - Schröder, Rolf A1 - Fürst, Dieter Oswald A1 - Klasen, Christian A1 - Reiman, Jens A1 - Herrmann, Harald A1 - VanDerVen, Peter F. M. T1 - The association of plectin with Z-discs is a prerequisite for the formation of the intermyofibrillar desmin cytoskeleton Y1 - 2000 ER - TY - JOUR A1 - VanDerVen, Peter F. M. A1 - Bartsch, Jörg A1 - Gautel, Mathias A1 - Jokusch, Harald A1 - Fürst, Dieter Oswald T1 - A functional knock-out of titin results in defective myofibril assembly Y1 - 2000 ER - TY - JOUR A1 - VanDerVen, Peter F. M A1 - Obermann, Wolfgang A1 - Lemke, Britt A1 - Gautel, Mathias A1 - Weber, Klaus A1 - Fürst, Dieter Oswald T1 - The characterization of muscle filamin isoforms suggests a possible role of ABP-L/gamma-filamin in sarcomeric Z- disc formation Y1 - 2000 ER - TY - JOUR A1 - Himmel, Mirko A1 - VanderVen, Peter F. M. A1 - Stöcklein, Walter F. M. A1 - Fürst, Dieter Oswald T1 - The limits of promiscuity : isoform-specific dimerization of filamins Y1 - 2003 ER - TY - JOUR A1 - Gehmlich, Katja A1 - Geier, C. A1 - Osterziel, Karl Joseph A1 - Fürst, Dieter Oswald T1 - Mutant muscle LIM protein is associated with hypertrophic cardiomyopathy and exhibits altered binding properties in the system MLP - N-RAP - alpha-actinin Y1 - 2004 SN - 0171-9335 ER - TY - JOUR A1 - Gehmlich, Katja A1 - Geier, C. A1 - Osterziel, Karl Joseph A1 - VanderVen, Peter F. M. A1 - Fürst, Dieter Oswald T1 - Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy N2 - Previous work has shown that mutations in muscle LIM protein (MLP) can cause hypertrophic cardiomyopathy (HCM). In order to gain an insight into the molecular basis of the disease phenotype, we analysed the binding characteristics of wild-type MLP and of the (C58G) mutant MLP that causes hypertrophic cardiomyopathy. We show that MLP can form a ternary complex with two of its previously documented myofibrillar ligand proteins, N-RAP and alpha-actinin, which indicates the presence of distinct, non-overlapping binding sites. Our data also show that, in comparison to wild-type MLP, the capacity of the mutated MLP protein to bind both N-RAP and alpha-actinin is significantly decreased. In addition, this single point mutation prevents zinc coordination and proper folding of the second zinc-finger in the first LIM domain, which consequently renders the protein less stable and more susceptible to proteolysis. The molecular basis for HCM-causing mutations in the MLP gene might therefore be an alteration in the equilibrium of interactions of the ternary complex MLP-N-RAP-alpha-actinin. This assumption is supported by the previous observation that in the pathological situation accompanied by MLP down regulation, cardiomyocytes try to compensate for the decreased stability of MLP protein by increasing the expression of its ligand N-RAP, which might finally result in the development of myocyte disarray that is characteristic of this disease Y1 - 2004 SN - 0302-766X ER - TY - JOUR A1 - Pacholsky, Dirk A1 - Vakeel, Padmanabhan A1 - Himmel, Mirko A1 - Lowe, T. A1 - Stradal, T. A1 - Rottner, K. A1 - Fürst, Dieter Oswald A1 - vanderVen, Peter F. M. T1 - Xin repeats define a novel actin-binding motif N2 - Xin is a protein that is expressed during early developmental stages of cardiac and skeletal muscles. Immunolocalization studies indicated a peripheral localization in embryonic mouse heart, where Xin localizes with beta- catenin and N-cadherin. In adult tissues, Xin is found primarily in the intercalated discs of cardiomyocytes and the myotendinous junctions of skeletal muscle cells, both specialized attachment sites of the myofibrillar ends to the sarcolemma. A large part of the Xin protein consists of unique 16 amino acid repeats with unknown function. We have investigated the characteristics of the Xin repeats by transfection experiments and actin-binding assays and ascertained that, upon expression in cultured cells, these repeats bind to and stabilize the actin-based cytoskeleton. In vitro co- sedimentation assays with skeletal muscle actin indicated that they not only directly bind actin filaments, but also have the capability of arranging microfilaments into networks that sediment upon low-speed centrifugation. Very similar repeats were also found in Xin-repeat protein 2' (XIRP2), a novel protein that seems to be expressed mainly in striated muscles. Human XIRP2 contains 28 Xin repeats with properties identical to those of Xin. We conclude that the Xin repeats define a novel, repetitive actin-binding motif present in at least two different muscle proteins. These Xin- repeat proteins therefore constitute the first two members of a novel family of actin-binding proteins Y1 - 2004 SN - 0021-9533 ER - TY - JOUR A1 - Lange, Stephan A1 - Himmel, Mirko A1 - Auerbach, Daniel A1 - Agarkova, Irina A1 - Hayess, Katrin A1 - Fürst, Dieter Oswald A1 - Perriard, Jean-Claude A1 - Ehler, Elisabeth T1 - Dimerisation of myomesin : implications for the structure of the sarcomeric M-band N2 - The sarcomeric M-band is thought to provide a link between the thick and the elastic, filament systems. So far, relatively little is known about its structural components and their three-dimensional organisation. Myomesin seems to be an essential component of the M-band, since it is expressed in all types of vertebrate striated muscle fibres investigated and can be found in its mature localisation pattern as soon as the first myofibrils are assembled. Previous work has shown that the N-terminal and central part of myomesin harbour binding sites for myosin, titin and muscle creatine kinase. Intrigued by the highly conserved domain layout of the C-terminal half, we screened for new interaction partners by yeast two-hybrid analysis. This revealed a strong interaction of myomesin with itself. This finding was confirmed by several biochemical assays. Our data suggest that myomesin can form antiparallel dimers via a binding site residing in its C-terminal domain 13. We suggest that, similar to alpha-actinin in the Z-disc, the myomesin dimers cross- link the contractile filaments in the M-band. The new and the already previously identified myomesin interaction sites are integrated into the first three-dimensional model of the sarcomeric M-band on a molecular basis. (C) 2004 Elsevier Ltd. All rights reserved Y1 - 2005 SN - 0022-2836 ER - TY - JOUR A1 - Vorgerd, M. A1 - vanderVen, Peter F. M. A1 - Bruchertseifer, V. A1 - Lowe, T. A1 - Kley, R. A. A1 - Schröder, Rolf A1 - Lochmuller, H. A1 - Himmel, Mirko A1 - Koehler, K. A1 - Fürst, Dieter Oswald A1 - Huebner, A. T1 - A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy N2 - Myofibrillar myopathy (MFM) is a human disease that is characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. In an extended German pedigree with a novel form of MFM characterized by clinical features of a limb-girdle myopathy and morphological features of MFM, we identified a cosegregating, heterozygous nonsense mutation (8130G -> A; W2710X) in the filamin c gene ( FLNC) on chromosome 7q32.1. The mutation is the first found in FLNC and is localized in the dimerization domain of filamin c. Functional studies showed that, in the truncated mutant protein, this domain has a disturbed secondary structure that leads to the inability to dimerize properly. As a consequence of this malfunction, the muscle fibers of our patients display massive cytoplasmic aggregates containing filamin c and several Z-disk-associated and sarcolemmal proteins Y1 - 2005 SN - 0002-9297 ER - TY - JOUR A1 - Raynaud, F A1 - Jond-Necand, C A1 - Marcilhac, Anne A1 - Fürst, Dieter Oswald A1 - Benyamin, Yves T1 - Calpain 1-gamma filamin interaction in muscle cells : a possible in situ regulation by PKC-alpha Y1 - 2006 ER - TY - JOUR A1 - Raynaud, F A1 - Jond-Necand, C A1 - Marcilhac, Anne A1 - Fürst, Dieter Oswald A1 - Benyamin, Yves T1 - Calpain 1-gamma filamin interaction in muscle cells :a possible in situ regulation by PKC-alpha Y1 - 2006 ER - TY - JOUR A1 - VanderVen, Peter F. M. A1 - Ehler, Elisabeth A1 - Vakeel, Padmanabhan A1 - Eulitz, Stefan A1 - Schenk, Jörg A. A1 - Milting, Hendrik A1 - Micheel, Burkhard A1 - Fürst, Dieter Oswald T1 - Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/ VASP N2 - Filamin c is the predominantly expressed filamin isoform in striated muscles. It is localized in myofibrillar Z- discs, where it binds FATZ and myotilin, and in myotendinous junctions and intercalated discs. Here, we identify Xin, the protein encoded by the human gene 'cardiomyopathy associated 1' (CMYA1) as filamin c binding partner at these specialized structures where the ends of myofibrils are attached to the sarcolemma. Xin directly binds the EVH1 domain proteins Mena and VASP. In the adult heart, Xin and Mena/VASP colocalize with filamin c in intercalated discs. In cultured cardiomyocytes, the proteins also localize in the nonstriated part of myofibrils, where sarcomeres are assembled and an extensive reorganization of the actin cytoskeleton occurs. Unusual intraexonic splicing events result in the existence of three Xin isoforms that associate differentially with its ligands. The identification of the complex filamin c-Xin-Mena/VASP provides a first glance on the role of Xin in the molecular mechanisms involved in developmental and adaptive remodeling of the actin cytoskeleton during cardiac morphogenesis and sarcomere assembly. (c) 2006 Elsevier Inc. All rights reserved Y1 - 2006 U6 - https://doi.org/10.1016/j.yexcr.2006.03.015 ER -