TY - JOUR A1 - Cannestra, Andrew F. A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth A1 - Villringer, Arno A1 - Toga, Arthur W. T1 - Functional assessment of Broca's area using near infrared spectroscopy in humans Y1 - 2003 UR - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft SN - 0959-4965 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Burchert, Frank A1 - Heekeren, Hauke R. A1 - De Bleser, Ria A1 - Villringer, Arno T1 - Grammaticality judgments on sentences with and without movement of phrasal constituents : an event-related fMRI study Y1 - 2003 UR - http://www.sciencedirect.com/science/journal/09116044 SN - 0911-6044 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Schmidt, Helge A1 - Schwintowski, Hans-Peter A1 - Villringer, Arno T1 - An fMRI study of simple ethical decision-making Y1 - 2003 UR - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft SN - 0959-4965 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Abutalebi, Jubin A1 - Cappa, Stefano F. A1 - Villringer, Arno A1 - Perani, Daniela T1 - Early setting of grammatical processing in the bilingual brain Y1 - 2003 UR - http://www.cell.com/neuron/home SN - 0896-6273 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Burchert, Frank A1 - Heinemann, Steffi A1 - De Bleser, Ria A1 - Villringer, Arno T1 - Neural correlates of syntactic transformations N2 - Many agrammatic aphasics have a specific syntactic comprehension deficit involving processing syntactic transformations. It has been proposed that this deficit is due to a dysfunction of Broca's area, an area that is thought to be critical for comprehension of complex transformed sentences. The goal of this study was to investigate the role of Broca's area in processing canonical and non-canonical sentences in healthy subjects. The sentences were presented auditorily and were controlled for task difficulty. Subjects were asked to judge the grammaticality of the sentences while their brain activity was monitored using event-related functional magnetic resonance imaging. Processing both kinds of sentences resulted in activation of language-related brain regions. Comparison of non-canonical and canonical sentences showed greater activation in bilateral temporal regions; a greater activation of Broca's area in processing antecedent-gap relations was not found. Moreover, the posterior part of Broca's area was conjointly activated by both sentence conditions. Broca's area is thus involved in general syntactic processing as required by grammaticality judgments and does not seem to have a specific role in processing syntactic transformations. (C) 2004 Wiley-Liss, Inc Y1 - 2004 UR - http://www3.interscience.wiley.com/journal/38751/home SN - 1065-9471 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Schmidt, Helge A1 - Prehn, Kristin A1 - Schwintowski, Hans-Peter A1 - Villringer, Arno T1 - Influence of bodily harm on neural correlates of semantic and moral decision-making N2 - Moral decision-making is central to everyday social life because the evaluation of the actions of another agent or our own actions made with respect to the norms and values guides our behavior in a community. There is previous evidence that the presence of bodily harm-even if irrelevant for a decision-may affect the decision-making, process. While recent neuroimaging studies found a common neural substrate of moral decision-making, the role of bodily harm has not been systematically studied so far. Here we used event-related functional magnetic resonance imaging (fMRI) to investigate how behavioral and neural correlates of semantic and moral decision-making processes are modulated by the presence of direct bodily harm or violence in the stimuli. Twelve participants made moral and semantic decisions about sentences describing actions of agents that either contained bodily harm or not and that could easily be judged as being good or bad or correct/incorrect, respectively. During moral and semantic decision-making, the presence of bodily harm resulted in faster response times (RT) and weaker activity in the temporal poles relative to trials devoid of bodily harm/violence, indicating a processing advantage and reduced processing depth for violence-related linguistic stimuli. Notably, there was no increase in activity in the amygdala and the posterior cingulate cortex (PCC) in response to trials containing bodily harm. These findings might be a correlate of limited generation of the semantic and emotional context in the anterior temporal poles during the evaluation of actions of another agent related to violence that is made with respect to the norms and values guiding our behavior in a community. (C) 2004 Elsevier Inc. All rights reserved Y1 - 2005 SN - 1053-8119 ER - TY - JOUR A1 - Mell, Thomas A1 - Heekeren, Hauke R. A1 - Marschner, Alexander A1 - Wartenburger, Isabell A1 - Villringer, Arno A1 - Reischies, Friedel M. T1 - Effect of aging on stimulus-reward association learning N2 - The flexible learning of stimulus-reward associations when required by situational context is essential for everyday behavior. Older adults experience a progressive decline in several cognitive functions and show deficiencies in neuropsychological tasks requiring flexible adaptation to external feedback, which could be related to impairments in reward association learning. To study the effect of aging on stimulus-reward association learning 20 young and 20 older adults performed a probabilistic object reversal task (pORT) along with a battery of tests assessing executive functions and general intellectual abilities. The pORT requires learning and reversing associations between actions and their outcomes. Older participants collected fewer points, needed more trials to reach the learning criterion, and completed less blocks successfully compared to young adults. This difference remained statistically significant after correcting for the age effect of other tests assessing executive functions. This suggests that there is an age-related difference in reward association learning as measured using the pORT, which is not closely related to other executive functions with respect to the age effect. In human aging, structural alterations of reward detecting structures and functional changes of the dopaminergic as well as the serotonergic system might contribute to the deficit in reward association learning observed in this study. (C) 2004 Elsevier Ltd. All rights reserved Y1 - 2005 SN - 0028-3932 ER - TY - JOUR A1 - Mériau, Katja A1 - Kazzer, Philipp A1 - Wartenburger, Isabell A1 - Prehn, Kristin A1 - Lammers, Claas-Hinrich A1 - Villringer, Arno A1 - Heekeren, Hauke T1 - Neural correlates of individual differences in the ability to identify and communicate one's emotional state Y1 - 2005 SN - 0898-929X ER - TY - JOUR A1 - Marschner, Alexander A1 - Mell, Thomas A1 - Wartenburger, Isabell A1 - Villringer, Arno A1 - Reischies, Friedel M. A1 - Heekeren, Hauke R. T1 - Reward-based decision-making and aging Y1 - 2005 SN - 0361-9230 ER - TY - JOUR A1 - Scheibe, Christina A1 - Wartenburger, Isabell A1 - Wüstenberg, Torsten A1 - Kathmann, Norbert A1 - Villringer, Arno A1 - Heekeren, Hauke R. T1 - Neural correlates of the interaction between transient and sustained processes : a mixed blocked/event-related fMRI study Y1 - 2006 UR - http://www3.interscience.wiley.com/journal/38751/home SN - 1065-9471 ER - TY - JOUR A1 - Wartenburger, Isabell T1 - Wie verändert der (Fremd-)Spracherwerb das Gehirn? : Einfluss von Erwerbsalter und Sprachleistungsniveau auf die kortikale Repräsentation grammatikalischer und semantischer Verarbeitungsprozesse Y1 - 2006 SN - 3-88246-298-1 ER - TY - JOUR A1 - Mériau, Katja A1 - Wartenburger, Isabell A1 - Kazzer, Philipp A1 - Prehn, Kristin A1 - Lammers, Claas-Hinrich A1 - van der Meer, Elke A1 - Villringer, Arno A1 - Heekeren, Hauke R. T1 - A neural network reflecting individual differences in cognitive processing of emotions during perceptual decision making Y1 - 2006 SN - 1053-8119 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Steinbrink, Jens A1 - Telkemeyer, Silke A1 - Friedrich, Manuela A1 - Friederici, Angela D. A1 - Obrig, Hellmuth T1 - The processing of prosody : evidence of interhemispheric specialization at the age of four Y1 - 2007 SN - 1053-8119 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Marschner, Alexander A1 - Mell, Thomas A1 - Villringer, Arno A1 - Reischies, Friedel M. T1 - Role of ventral striatum in reward-based decision making Y1 - 2007 SN - 0959-4965 ER - TY - JOUR A1 - Prehn, Kristin A1 - Wartenburger, Isabell A1 - Mériau, Katja A1 - Scheibe, Christina A1 - Goodenough, Oliver R. A1 - Villringer, Arno A1 - van der Meer, Elke A1 - Heekeren, Hauke R. T1 - Individual differences in moral judgment competence influence neural correlates of socio-normative judgments Y1 - 2008 UR - http://scan.oxfordjournals.org/content/by/year SN - 1749-5016 ER - TY - JOUR A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Koch, Stefan P. A1 - Nierhaus, Till A1 - Steinbrink, Jens A1 - Poeppel, David A1 - Obrig, Hellmuth A1 - Wartenburger, Isabell T1 - Sensitivity of newborn auditory cortex to the temporal structure of sounds N2 - Understanding the rapidly developing building blocks of speech perception in infancy requires a close look at the auditory prerequisites for speech sound processing. Pioneering studies have demonstrated that hemispheric specializations for language processing are already present in early infancy. However, whether these computational asymmetries can be considered a function of linguistic attributes or a consequence of basic temporal signal properties is under debate. Several studies in adults link hemispheric specialization for certain aspects of speech perception to an asymmetry in cortical tuning and reveal that the auditory cortices are differentially sensitive to spectrotemporal features of speech. Applying concurrent electrophysiological (EEG) and hemodynamic (near-infrared spectroscopy) recording to newborn infants listening to temporally structured nonspeech signals, we provide evidence that newborns process nonlinguistic acoustic stimuli that share critical temporal features with language in a differential manner. The newborn brain preferentially processes temporal modulations especially relevant for phoneme perception. In line with multi-time-resolution conceptions, modulations on the time scale of phonemes elicit strong bilateral cortical responses. Our data furthermore suggest that responses to slow acoustic modulations are lateralized to the right hemisphere. That is, the newborn auditory cortex is sensitive to the temporal structure of the auditory input and shows an emerging tendency for functional asymmetry. Hence, our findings support the hypothesis that development of speech perception is linked to basic capacities in auditory processing. From birth, the brain is tuned to critical temporal properties of linguistic signals to facilitate one of the major needs of humans: to communicate. Y1 - 2009 UR - http://www.jneurosci.org/ U6 - https://doi.org/10.1523/Jneurosci.1246-09.2009 SN - 0270-6474 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Preusse, Franziska A1 - Kramer, Jürg A1 - van der Meer, Elke T1 - Cerebral correlates of analogical processing and their modulation by training N2 - There is increasing interest ill understanding the neural systems that mediate analogical thinking, which is essential for learning and fluid intelligence. The aim of the present study was to shed light on the cerebral correlates of geometric analogical processing and on training-induced changes at the behavioral and brain level. In healthy participants a bilateral fronto-parietal network was engaged in processing geometric analogies and showed greater blood oxygenation dependent (BOLD) signals as resource demands increased. This network, as well as fusiform and subcortical brain regions, additionally showed training-induced decreases in the BOLD signal over time. The general finding that brain regions were modulated by the amount of resources demanded by the task, and/or by the reduction of allocated resources due to short term training, reflects increased efficiency - in terms of more focal and more specialized brain activation - to more economically process the geometric analogies. Our data indicate a rapid adaptation of the cognitive system which is efficiently modulated by short term training based on a positive correlation of resource demands and brain activation. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/10538119 U6 - https://doi.org/10.1016/j.neuroimage.2009.06.025 SN - 1053-8119 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Kühn, Esther A1 - Sassenberg, Uta A1 - Foth, Manja A1 - Franz, Elizabeth A. A1 - van derMeer, Elke T1 - On the relationship between fluid intelligence, gesture production, and brain structure Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/01602896 SN - 0160-2896 ER - TY - JOUR A1 - Mériau, Katja A1 - Wartenburger, Isabell A1 - Kazzer, Philipp A1 - Prehn, Kristin A1 - Villringer, Arno A1 - van der Meer, Elke A1 - Heekeren, Hauke R. T1 - Insular activity during passive viewing of aversive stimuli reflects individual differences in state negative affect N2 - People differ with regard to how they perceive, experience, and express negative affect. While trait negative affect reflects a stable, sustained personality trait, state negative affect represents a stimulus limited and temporally acute emotion. So far, little is known about the neural systems mediating the relationship between negative affect and acute emotion processing. To address this issue we investigated in a healthy female sample how individual differences in state negative affect are reflected in changes in blood oxygen level-dependent responses during passive viewing of emotional stimuli. To assess autonomic arousal we simultaneously recorded changes in skin conductance level. At the psychophysiological level we found increased skin conductance level in response to aversive relative to neutral pictures. However, there was no association of state negative affect with skin conductance level. At the neural level we found that high state negative affect was associated with increased left insular activity during passive viewing of aversive stimuli. The insula has been implicated in interoceptive processes and in the integration of sensory, visceral, and affective information thus contributing to subjective emotional experience. Greater recruitment of the insula in response to aversive relative to neutral stimuli in subjects with high state negative affect may represent increased processing of salient aversive stimuli. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/02782626 U6 - https://doi.org/10.1016/j.bandc.2008.05.006 SN - 0278-2626 ER - TY - GEN A1 - Mell, Thomas A1 - Wartenburger, Isabell A1 - Marschner, Alexander A1 - Villringer, Arno A1 - Reischies, Friedel M. A1 - Heekeren, Hauke R. T1 - Altered function of ventral striatum during reward-based decision making in old age N2 - Normal aging is associated with a decline in different cognitive domains and local structural atrophy as well as decreases in dopamine concentration and receptor density. To date, it is largely unknown how these reductions in dopaminergic neurotransmission affect human brain regions responsible for reward-based decision making in older adults. Using a learning criterion in a probabilistic object reversal task, we found a learning stage by age interaction in the dorsolateral prefrontal cortex (dIPFC) during decision making. While young adults recruited the dlPFC in an early stage of learning reward associations, older adults recruited the dlPFC when reward associations had already been learned. Furthermore, we found a reduced change in ventral striatal BOLD signal in older as compared to younger adults in response to high probability rewards. Our data are in line with behavioral evidence that older adults show altered stimulus-reward learning and support the view of an altered fronto-striatal interaction during reward-based decision making in old age, which contributes to prolonged learning of reward associations. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - paper 182 KW - aging KW - fMRI KW - reward association learning KW - ventral striatum KW - decision making KW - dorsolateral prefrontal cortex Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45235 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Kühn, Esther A1 - Sassenberg, Uta A1 - Foth, Manja A1 - Franz, Elisabeth A. A1 - van der Meer, Elke T1 - On the relationship between fluid intelligence, gesture production, and brain structure N2 - Individuals scoring high in fluid intelligence tasks generally perform very efficiently in problem solving tasks and analogical reasoning tasks presumably because they are able to select the task-relevant information very quickly and focus on a limited set of task-relevant cognitive operations. Moreover, individuals with high fluid intelligence produce more representational hand and arm gestures when describing a geometric analogy task than individuals with average fluid intelligence. No study has yet addressed the relationship between intelligence, gesture production, and brain structure, to our knowledge. That was the purpose of our study. To characterize the relation between intelligence, gesture production, and brain structure we assessed the frequency of representational gestures and cortical thickness values in a group of adolescents differing in fluid intelligence. Individuals scoring high in fluid intelligence showed higher accuracy in the geometric analogy task and produced more representational gestures (in particular more movement gestures) when explaining how they solved the task and showed larger cortical thickness values in some regions in the left hemisphere (namely the pars opercularis, superior frontal, and temporal cortex) than individuals with average fluid intelligence. Moreover, the left pars opercularis (a part of Broca's area) and left transverse temporal cortex showed larger cortical thickness values in participants who produced representational and in particular movement gestures compared to those who did not. Our results thus indicate that cortical thickness of those brain regions is related to both high fluid intelligence and the production of gestures. Results are discussed in the gestures-as-simulated-action framework that states that gestures result from simulated perception and simulated action that underlie embodied language and mental imagery. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/01602896 U6 - https://doi.org/10.1016/j.intell.2009.11.001 SN - 0160-2896 ER - TY - JOUR A1 - van der Meer, Elke A1 - Beyer, Reinhard A1 - Horn, Judith A1 - Foth, Manja A1 - Bornemann, Boris A1 - Ries, Jan A1 - Kramer, Jürg A1 - Warmuth, Elke A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Resource allocation and fluid intelligence ; insights from pupillometry Y1 - 2010 UR - http://www3.interscience.wiley.com/journal/118485671/home?CRETRY=1&SRETRY=0 SN - 0048-5772 ER - TY - JOUR A1 - Wartenburger, Isabell T1 - Gehirn und Sprache : wie wir Sprache(n) erlernen und verarbeiten Y1 - 2010 SN - 978-3-8340-0654-7 ER - TY - JOUR A1 - Aichert, Ingrid A1 - Staiger, Anja A1 - Schulte-Mäter, Anne A1 - Becker-Redding, Ulrike A1 - Stahn, Corinna A1 - Peschke, Claudia A1 - Heide, Judith A1 - Ott, Susan A1 - Herrmann, Heike A1 - Völsch, Juliane A1 - Mayer, Jörg A1 - Rohnke, Lucie A1 - Frank, Ulrike A1 - Stadie, Nicole A1 - Jentsch, Nadine A1 - Blech, Anke A1 - Kurtenbach, Stephanie A1 - Thieke, Johanna A1 - Schröder, Astrid A1 - Stahn, Corinna A1 - Hörnig, Robin A1 - Burchert, Frank A1 - De Bleser, Ria A1 - Heister, Julian A1 - Bartels, Luise A1 - Würzner, Kay-Michael A1 - Böhme, Romy A1 - Burmester, Juliane A1 - Krajewski, Melanie A1 - Nager, Wido A1 - Jungehülsing, Gerhard Jan A1 - Wartenburger, Isabell A1 - Jöbges, Michael A1 - Schwilling, Eleonore A1 - Lidzba, Karen A1 - Winkler, Susanne A1 - Konietzko, Andreas A1 - Krägeloh-Mann, Ingeborg A1 - Rilling, Eva A1 - Wilken, Rainer A1 - Wismann, Kathrin A1 - Glandorf, Birte A1 - Hoffmann, Hannah A1 - Hinnenkamp, Christiane A1 - Rohlmann, Insa A1 - Ludewigt, Jacqueline A1 - Bittner, Christian A1 - Orlov, Tatjana A1 - Claus, Katrin A1 - Ehemann, Christine A1 - Winnecken, Andreas A1 - Hummel, Katja A1 - Breitenstein, Sarah ED - Wahl, Michael ED - Stahn, Corinna ED - Hanne, Sandra ED - Fritzsche, Tom T1 - Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen N2 - Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universität Potsdam statt. Der vorliegende Tagungsband enthält die drei Hauptvorträge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen“. Darüber hinaus enthält der Band die Beiträge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpräsentationen. N2 - The 3rd Herbsttreffen Patholinguistik was held on November 21st, 2009 at the University of Potsdam. These proceedings contain the three main lectures of the central topic „From programming to articulation: Apraxia of speech of children and adults “. Additionally this volume contains the contributions of Spektrum Patholinguistik, as well as the abstracts of the poster presentations. T3 - Spektrum Patholinguistik - 3 KW - Patholinguistik KW - Sprechapraxie KW - Sprachtherapie KW - patholinguistics KW - apraxia of speech KW - speech and language therapy Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45470 SN - 978-3-86956-079-3 SN - 1869-3822 SN - 1866-9433 IS - 3 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Böhme, Romy A1 - Burmester, Juliane A1 - Krajewski, Melanie A1 - Nager, Wido A1 - Jungehülsing, Gerhard Jan A1 - Schröder, Astrid A1 - Wartenburger, Isabell A1 - Jöbges, Michael T1 - Transkranielle Gleichstromstimulation (tDCS) BT - zur Entwicklung einer Therapiestudie in der Behandlung von aphasischen Störungen des mündlichen Bildbenennens JF - Spektrum Patholinguistik Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-47045 SN - 1866-9085 SN - 1866-9433 VL - 3 SP - 167 EP - 174 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Rossi, Sonja A1 - Jürgenson, Ina B. A1 - Hanulikova, Adriana A1 - Telkemeyer, Silke A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth T1 - Implicit processing of phonotactic cues evidence from electrophysiological and vascular responses JF - Journal of cognitive neuroscience N2 - Spoken word recognition is achieved via competition between activated lexical candidates that match the incoming speech input. The competition is modulated by prelexical cues that are important for segmenting the auditory speech stream into linguistic units. One such prelexical cue that listeners rely on in spoken word recognition is phonotactics. Phonotactics defines possible combinations of phonemes within syllables or words in a given language. The present study aimed at investigating both temporal and topographical aspects of the neuronal correlates of phonotactic processing by simultaneously applying ERPs and functional near-infrared spectroscopy (fNIRS). Pseudowords, either phonotactically legal or illegal with respect to the participants' native language, were acoustically presented to passively listening adult native German speakers. ERPs showed a larger N400 effect for phonotactically legal compared to illegal pseudowords, suggesting stronger lexical activation mechanisms in phonotactically legal material. fNIRS revealed a left hemispheric network including fronto-temporal regions with greater response to phonotactically legal pseudowords than to illegal pseudowords. This confirms earlier hypotheses on a left hemispheric dominance of phonotactic processing most likely due to the fact that phonotactics is related to phonological processing and represents a segmental feature of language comprehension. These segmental linguistic properties of a stimulus are predominantly processed in the left hemisphere. Thus, our study provides first insights into temporal and topographical characteristics of phonotactic processing mechanisms in a passive listening task. Differential brain responses between known and unknown phonotactic rules thus supply evidence for an implicit use of phonotactic cues to guide lexical activation mechanisms. Y1 - 2011 U6 - https://doi.org/10.1162/jocn.2010.21547 SN - 0898-929X VL - 23 IS - 7 SP - 1752 EP - 1764 PB - MIT Press CY - Cambridge ER - TY - JOUR A1 - Preusse, Franziska A1 - van der Meer, Elke A1 - Deshpande, Gopikrishna A1 - Krüger, Frank A1 - Wartenburger, Isabell T1 - Fluid intelligence allows flexible recruitment of the parieto-frontal network in analogical reasoning JF - Frontiers in human neuroscienc N2 - Fluid intelligence is the ability to think flexibly and to understand abstract relations. People with high fluid intelligence (hi-fluIQ) perform better in analogical reasoning tasks than people with average fluid intelligence (ave-fluIQ). Although previous neuroimaging studies reported involvement of parietal and frontal brain regions in geometric analogical reasoning (which is a prototypical task for fluid intelligence), however, neuroimaging findings on geometric analogical reasoning in hi-fluIQ are sparse. Furthermore, evidence on the relation between brain activation and intelligence while solving cognitive tasks is contradictory. The present study was designed to elucidate the cerebral correlates of geometric analogical reasoning in a sample of hi-fluIQ and ave-fluIQ high school students. We employed a geometric analogical reasoning task with graded levels of task difficulty and confirmed the involvement of the parieto-frontal network in solving this task. In addition to characterizing the brain regions involved in geometric analogical reasoning in hi-fluIQ and ave-fluIQ, we found that blood oxygenation level dependency (BOLD) signal changes were greater for hi-fluIQ than for ave-fluIQ in parietal brain regions. However, ave-fluIQ showed greater BOLD signal changes in the anterior cingulate cortex and medial frontal gyrus than hi-fluIQ. Thus, we showed that a similar network of brain regions is involved in geometric analogical reasoning in both groups. Interestingly, the relation between brain activation and intelligence is not mono-directional, but rather, it is specific for each brain region. The negative brain activation-intelligence relationship in frontal brain regions in hi-fluIQ goes along with a better behavioral performance and reflects a lower demand for executive monitoring compared to ave-fluIQ individuals. In conclusion, our data indicate that flexibly modulating the extent of regional cerebral activity is characteristic for fluid intelligence. KW - high fluid intelligence KW - geometric analogical reasoning KW - task difficulty KW - functional magnetic resonance imaging KW - parieto-frontal network Y1 - 2011 U6 - https://doi.org/10.3389/fnhum.2011.00022 SN - 1662-5161 VL - 5 IS - 3 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Nierhaus, Till A1 - Steinbrink, Jens A1 - Obrig, Hellmuth A1 - Wartenburger, Isabell T1 - Acoustic processing of temporally modulated sounds in infants evidence from a combined near-infrared spectroscopy and EEG study JF - Frontiers in psychology N2 - Speech perception requires rapid extraction of the linguistic content from the acoustic signal. The ability to efficiently process rapid changes in auditory information is important for decoding speech and thereby crucial during language acquisition. Investigating functional networks of speech perception in infancy might elucidate neuronal ensembles supporting perceptual abilities that gate language acquisition. Interhemispheric specializations for language have been demonstrated in infants. How these asymmetries are shaped by basic temporal acoustic properties is under debate. We recently provided evidence that newborns process non-linguistic sounds sharing temporal features with language in a differential and lateralized fashion. The present study used the same material while measuring brain responses of 6 and 3 month old infants using simultaneous recordings of electroencephalography (EEG) and near-infrared spectroscopy (NIRS). NIRS reveals that the lateralization observed in newborns remains constant over the first months of life. While fast acoustic modulations elicit bilateral neuronal activations, slow modulations lead to right-lateralized responses. Additionally, auditory-evoked potentials and oscillatory EEG responses show differential responses for fast and slow modulations indicating a sensitivity for temporal acoustic variations. Oscillatory responses reveal an effect of development, that is, 6 but not 3 month old infants show stronger theta-band desynchronization for slowly modulated sounds. Whether this developmental effect is due to increasing fine-grained perception for spectrotemporal sounds in general remains speculative. Our findings support the notion that a more general specialization for acoustic properties can be considered the basis for lateralization of speech perception. The results show that concurrent assessment of vascular based imaging and electrophysiological responses have great potential in the research on language acquisition. KW - infants KW - speech perception KW - language acquisition KW - auditory processing KW - near-infrared spectroscopy KW - event related potentials KW - brain oscillations Y1 - 2011 U6 - https://doi.org/10.3389/fpsyg.2011.00062 SN - 1664-1078 VL - 2 IS - 2 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Wellmann, Caroline A1 - Holzgrefe-Lang, Julia A1 - Truckenbrodt, Hubert A1 - Wartenburger, Isabell A1 - Höhle, Barbara T1 - How each prosodic boundary cue matters evidence from German infants JF - Frontiers in psychology N2 - Previous studies have revealed that infants aged 6-10 months are able to use the acoustic correlates of major prosodic boundaries, that is, pitch change, preboundary lengthening, and pause, for the segmentation of the continuous speech signal. Moreover, investigations with American-English- and Dutch-learning infants suggest that processing prosodic boundary markings involves a weighting of these cues. This weighting seems to develop with increasing exposure to the native language and to underlie crosslinguistic variation. In the following, we report the results of four experiments using the headturn preference procedure to explore the perception of prosodic boundary cues in German infants. We presented 8-month-old infants with a sequence of names in two different prosodic groupings, with or without boundary markers. Infants discriminated both sequences when the boundary was marked by all three cues (Experiment 1) and when it was marked by a pitch change and preboundary lengthening in combination (Experiment 2). The presence of a pitch change (Experiment 3) or preboundary lengthening (Experiment 4) as single cues did not lead to a successful discrimination. Our results indicate that pause is not a necessary cue for German infants. Pitch change and preboundary lengthening in combination, but not as single cues, are sufficient. Hence, by 8 months infants only rely on a convergence of boundary markers. Comparisons with adults' performance on the same stimulus materials suggest that the pattern observed with the 8-month-olds is already consistent with that of adults. We discuss our findings with respect to crosslinguistic variation and the development of a language-specific prosodic cue weighting. KW - infants KW - language acquisition KW - speech perception KW - prosodic bootstrapping KW - prosodic boundary cues KW - cue weighting KW - intonation phrase boundary KW - headturn preference procedure Y1 - 2012 U6 - https://doi.org/10.3389/fpsyg.2012.00580 SN - 1664-1078 VL - 3 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Rossi, Sonja A1 - Telkemeyer, Silke A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth T1 - Shedding light on words and sentences near-infrared spectroscopy in language research JF - Brain & language : a journal of the neurobiology of language N2 - Investigating the neuronal network underlying language processing may contribute to a better understanding of how the brain masters this complex cognitive function with surprising ease and how language is acquired at a fast pace in infancy. Modern neuroimaging methods permit to visualize the evolvement and the function of the language network. The present paper focuses on a specific methodology, functional near-infrared spectroscopy (fNIRS), providing an overview over studies on auditory language processing and acquisition. The methodology detects oxygenation changes elicited by functional activation of the cerebral cortex. The main advantages for research on auditory language processing and its development during infancy are an undemanding application, the lack of instrumental noise, and its potential to simultaneously register electrophysiological responses. Also it constitutes an innovative approach for studying developmental issues in infants and children. The review will focus on studies on word and sentence processing including research in infants and adults. KW - Language KW - Language acquisition KW - Word processing KW - Sentence processing KW - Lateralization KW - Optical imaging (OI) KW - Near-infrared spectroscopy (NIRS) KW - Electroencephalography (EEG) Y1 - 2012 U6 - https://doi.org/10.1016/j.bandl.2011.03.008 SN - 0093-934X VL - 121 IS - 2 SP - 152 EP - 163 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Schroder, Astrid A1 - Gemballa, Teresa A1 - Ruppin, Steffie A1 - Wartenburger, Isabell T1 - German norms for semantic typicality, age of acquisition, and concept familiarity JF - Behavior research methods : a journal of the Psychonomic Society N2 - The present study introduces the first substantial German database with norms for semantic typicality, age of acquisition, and concept familiarity for 824 exemplars of 11 semantic categories, including four natural ( and ) and five man-made (, and ) categories, as well as and Each category exemplar in the database was collected empirically in an exemplar generation study. For each category exemplar, norms for semantic typicality, estimated age of acquisition, and concept familiarity were gathered in three different rating studies. Reliability data and additional analyses on effects of semantic category and intercorrelations between age of acquisition, semantic typicality, concept familiarity, word length, and word frequency are provided. Overall, the data show high inter- and intrastudy reliabilities, providing a new resource tool for designing experiments with German word materials. The full database is available in the supplementary material of this file and also at www.psychonomic.org/archive. KW - Semantic typicality KW - Age of acquisition KW - Concept familiarity KW - Norm data KW - Semantic categories KW - German database KW - Lexical-semantic processing KW - Exemplar generation Y1 - 2012 U6 - https://doi.org/10.3758/s13428-011-0164-y SN - 1554-351X VL - 44 IS - 2 SP - 380 EP - 394 PB - Springer CY - New York ER - TY - JOUR A1 - Passow, Susanne A1 - Westerhausen, Rene A1 - Wartenburger, Isabell A1 - Hugdahl, Kenneth A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Human aging compromises attentional control of auditory perception JF - Psychology and aging N2 - Older adults often experience hearing difficulties in multitalker situations. Attentional control of auditory perception is crucial in situations where a plethora of auditory inputs compete for further processing. We combined an intensity-modulated dichotic listening paradigm with attentional manipulations to study adult age differences in the interplay between perceptual saliency and attentional control of auditory processing. When confronted with two competing sources of verbal auditory input, older adults modulated their attention less flexibly and were more driven by perceptual saliency than younger adults. These findings suggest that aging severely impairs the attentional regulation of auditory perception. KW - aging KW - auditory perception KW - attention KW - dichotic listening KW - hearing Y1 - 2012 U6 - https://doi.org/10.1037/a0025667 SN - 0882-7974 VL - 27 IS - 1 SP - 99 EP - 105 PB - American Psychological Association CY - Washington ER - TY - CHAP A1 - Lausberg, H. A1 - Kazzer, Philipp A1 - Heekeren, Hauke A1 - Wartenburger, Isabell T1 - Differential cortical mechanisms underlying tool use, pantomime, and body-part-as-object use T2 - European journal of neurology : the official journal of the European Federation of Neurological Societies Y1 - 2012 SN - 1351-5101 VL - 19 IS - 9 SP - 78 EP - 78 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Mehnert, Jan A1 - Akhrif, Atae A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Schmitz, Christoph H. A1 - Steinbrink, Jens A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth A1 - Neufang, Susanne T1 - Developmental changes in brain activation and functional connectivity during response inhibition in the early childhood brain JF - Brain and development : official journal of the Japanese Society of Child Neurology N2 - Response inhibition is an attention function which develops relatively early during childhood. Behavioral data suggest that by the age of 3, children master the basic task requirements for the assessment of response inhibition but performance improves substantially until the age of 7. The neuronal mechanisms underlying these developmental processes, however, are not well understood. In this study, we examined brain activation patterns and behavioral performance of children aged between 4 and 6 years compared to adults by applying a go/no-go paradigm during near-infrared spectroscopy (NIRS) brain imaging. We furthermore applied task-independent functional connectivity measures to the imaging data to identify maturation of intrinsic neural functional networks. We found a significant group x condition related interaction in terms of inhibition-related reduced right fronto-parietal activation in children compared to adults. In contrast, motor-related activation did not differ between age groups. Functional connectivity analysis revealed that in the children's group, short-range coherence within frontal areas was stronger, and long-range coherence between frontal and parietal areas was weaker, compared to adults. Our findings show that in children aged from 4 to 6 years fronto-parietal brain maturation plays a crucial part in the cognitive development of response inhibition. KW - Optical tomography KW - NIRS KW - Response inhibition KW - Functional connectivity KW - Development KW - Early childhood Y1 - 2013 U6 - https://doi.org/10.1016/j.braindev.2012.11.006 SN - 0387-7604 SN - 1872-7131 VL - 35 IS - 10 SP - 894 EP - 904 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Passow, Susanne A1 - Müller, Maike A1 - Westerhausen, Rene A1 - Hugdahl, Kenneth A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Development of attentional control of verbal auditory perception from middle to late childhood - comparisons to healthy aging JF - Developmental psychology N2 - Multitalker situations confront listeners with a plethora of competing auditory inputs, and hence require selective attention to relevant information, especially when the perceptual saliency of distracting inputs is high. This study augmented the classical forced-attention dichotic listening paradigm by adding an interaural intensity manipulation to investigate developmental differences in the interplay between perceptual saliency and attentional control during auditory processing between early and middle childhood. We found that older children were able to flexibly focus on instructed auditory inputs from either the right or the left ear, overcoming the effects of perceptual saliency. In contrast, younger children implemented their attentional focus less efficiently. Direct comparisons of the present data with data from a recently published study of younger and older adults from our group suggest that younger children and older adults show similar levels of performance. Critically, follow-up comparisons revealed that younger children's performance restrictions reflect difficulties in attentional control only, whereas older adults' performance deficits also reflect an exaggerated reliance on perceptual saliency. We conclude that auditory attentional control improves considerably from middle to late childhood and that auditory attention deficits in healthy aging cannot be reduced to a simple reversal of child developmental improvements. KW - child development KW - attentional control KW - auditory perception KW - aging KW - dichotic listening Y1 - 2013 U6 - https://doi.org/10.1037/a0031207 SN - 0012-1649 VL - 49 IS - 10 SP - 1982 EP - 1993 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Holzgrefe-Lang, Julia A1 - Wellmann, Caroline A1 - Petrone, Caterina A1 - Truckenbrodt, Hubert A1 - Höhle, Barbara A1 - Wartenburger, Isabell T1 - Brain response to prosodic boundary cues depends on boundary position JF - Frontiers in psychology N2 - Prosodic information is crucial for spoken language comprehension and especially for syntactic parsing, because prosodic cues guide the hearer's syntactic analysis. The time course and mechanisms of this interplay of prosody and syntax are not yet well-understood. In particular, there is an ongoing debate whether local prosodic cues are taken into account automatically or whether they are processed in relation to the global prosodic context in which they appear. The present study explores whether the perception of a prosodic boundary is affected by its position within an utterance. In an event-related potential (PRP) study we tested if the brain response evoked by the prosodic boundary differs when the boundary occurs early in a list of three names connected by conjunctions (i.e., after the first name) as compared to later in the utterance (i.e., after the second name). A closure positive shift (CPS)-marking the processing of a prosodic phrase boundary-was elicited for stimuli with a late boundary, but not for stimuli with an early boundary. This result is further evidence for an immediate integration of prosodic information into the parsing of an utterance. In addition, it shows that the processing of prosodic boundary cues depends on the previously processed information from the preceding prosodic context. KW - prosodic boundaries KW - event-related potentials KW - closure positive shift KW - speech perception KW - prosody Y1 - 2013 U6 - https://doi.org/10.3389/fpsyg.2013.00421 SN - 1664-1078 VL - 4 IS - 28 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Bos, Laura S. A1 - Hanne, Sandra A1 - Wartenburger, Isabell A1 - Bastiaanse, Roelien T1 - Losing track of time? Processing of time reference inflection in agrammatic and healthy speakers of German JF - Neuropsychologia : an international journal in behavioural and cognitive neuroscience N2 - Background: Individuals with agrammatic aphasia (IWAs) have problems with grammatical decoding of tense inflection. However, these difficulties depend on the time frame that the tense refers to. Verb morphology with reference to the past is more difficult than with reference to the non-past, because a link needs to be made to the past event in discourse, as captured in the PAst Discourse Linking Hypothesis (PADILIH; Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., Thompson, C. K., 2011. Time reference in agrammatic aphasia: A cross-linguistic study. J. Neurolinguist. 24, 652-673). With respect to reference to the (non-discourse-linked) future, data so far indicate that IWAs experience less difficulties as compared to past time reference (Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., Thompson, C. K., 2011. Time reference in agrammatic aphasia: A cross-linguistic study. J. Neurolinguist. 24, 652-673), supporting the assumptions of the PADILIH. Previous online studies of time reference in aphasia used methods such as reaction times analysis (e.g., Faroqi-Shah, Y., Dickey, M. W., 2009. On-line processing of tense and temporality in agrammatic aphasia. Brain Lang. 108, 97-111). So far, no such study used eye-tracking, even though this technique can bring additional insights (Burchert, F., Hanne, S., Vasishth, S., 2013. Sentence comprehension disorders in aphasia: the concept of chance performance revisited. Aphasiology 27, 112-125, doi:10.1080/02687038.2012.730603). Aims: This study investigated (1) whether processing of future and past time reference inflection differs between non-brain-damaged individuals (NBDs) and IWAs, and (2) underlying mechanisms of time reference comprehension failure by IWAs. Results and discussion: NBDs scored at ceiling and significantly higher than the IWAs. IWAs had below-ceiling performance on the future condition, and both participant groups were faster to respond to the past than to the future condition. These differences are attributed to a pre-existing preference to look at a past picture, which has to be overcome. Eye movement patterns suggest that both groups interpret future time reference similarly, while IWAs show a delay relative to NBDs in interpreting past time reference inflection. The eye tracking results support the PADILIH, because processing reference to the past in discourse syntax requires additional resources and thus, is problematic and delayed for people with aphasia. (C) 2014 Elsevier Ltd. All rights reserved. KW - Visual-world paradigm KW - Spoken language comprehension KW - Time reference KW - Morphology KW - Agrammatism KW - Eye-tracking KW - Aphasia KW - Discourse linking Y1 - 2014 U6 - https://doi.org/10.1016/j.neuropsychologia.2014.10.026 SN - 0028-3932 SN - 1873-3514 VL - 65 SP - 180 EP - 190 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Passow, Susanne A1 - Westerhausen, Rene A1 - Hugdahl, Kenneth A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Electrophysiological correlates of adult age differences in attentional control of auditory processing JF - Cerebral cortex N2 - In addition to sensory decline, age-related losses in auditory perception also reflect impairments in attentional modulation of perceptual saliency. Using an attention and intensity-modulated dichotic listening paradigm, we investigated electrophysiological correlates of processing conflicts between attentional focus and perceptual saliency in 25 younger and 26 older adults. Participants were instructed to attend to the right or left ear, and perceptual saliency was manipulated by varying the intensities of both ears. Attentional control demand was higher in conditions when attentional focus and perceptual saliency favored opposing ears than in conditions without such conflicts. Relative to younger adults, older adults modulated their attention less flexibly and were more influenced by perceptual saliency. Our results show, for the first time, that in younger adults a late negativity in the event-related potential (ERP) at fronto-central and parietal electrodes was sensitive to perceptual-attentional conflicts during auditory processing (N450 modulation effect). Crucially, the magnitude of the N450 modulation effect correlated positively with task performance. In line with lower attentional flexibility, the ERP waveforms of older adults showed absence of the late negativity and the modulation effect. This suggests that aging compromises the activation of the frontoparietal attentional network when processing the competing and conflicting auditory information. KW - aging KW - attention KW - auditory perception KW - conflict monitoring KW - ERP Y1 - 2014 U6 - https://doi.org/10.1093/cercor/bhs306 SN - 1047-3211 SN - 1460-2199 VL - 24 IS - 1 SP - 249 EP - 260 PB - Oxford Univ. Press CY - Cary ER - TY - JOUR A1 - Spalek, Katharina A1 - Gotzner, Nicole A1 - Wartenburger, Isabell T1 - Not only the apples BT - Focus sensitive particles improve memory for information-structural alternatives JF - Journal of memory and language : JML N2 - Focus sensitive particles highlight the relevance of contextual alternatives for the interpretation of a sentence. Two experiments tested whether this leads to better encoding and therefore, ultimately, better recall of focus alternatives. Participants were presented with auditory stimuli that introduced a set of elements ("context sentence") and continued in three different versions: the critical sentences either contained the exclusive particle nur ("only"), the inclusive particle sogar ("even"), or no particle (control condition). After being exposed to blocks of ten trials, participants were asked to recall the elements in the context sentence. The results show that both particles enhanced memory performance for the alternatives to the focused element, relative to the control condition. The results support the assumption that information-structural alternatives are better encoded in memory in the presence of a focus sensitive particle. KW - Information structure KW - Focus particles KW - Alternative set KW - Delayed recall KW - Memory Y1 - 2014 U6 - https://doi.org/10.1016/j.jml.2013.09.001 SN - 0749-596X SN - 1096-0821 VL - 70 SP - 68 EP - 84 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Burmester, Juliane A1 - Spalek, Katharina A1 - Wartenburger, Isabell T1 - Context updating during sentence comprehension: The effect of aboutness topic JF - Brain & language : a journal of the neurobiology of language KW - Information structure KW - Discourse context KW - Aboutness topic KW - Sentence processing KW - Word order variation KW - ERP KW - Late positivity KW - Syntax-Discourse Model Y1 - 2014 U6 - https://doi.org/10.1016/j.bandl.2014.08.001 SN - 0093-934X SN - 1090-2155 VL - 137 SP - 62 EP - 76 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Lausberg, Hedda A1 - Kazzer, Philipp A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Pantomiming tool use with an imaginary tool in hand as compared to demonstration with tool in hand specifically modulates the left middle and superior temporal gyri JF - Cortex : a journal devoted to the study of the nervous system and behaviour N2 - Neuropsychological lesion studies evidence the necessity to differentiate between various forms of tool-related actions such as real tool use, tool use demonstration with tool in hand and without physical target object, and pantomime without tool in hand. However, thus far, neuroimaging studies have primarily focused only on investigating tool use pantomimes. The present fMRI study investigates pantomime without tool in hand as compared to tool use demonstration with tool in hand in order to explore patterns of cerebral signal modulation associated with acting with imaginary tools in hand. Fifteen participants performed with either hand (i) tool use pantomime with an imaginary tool in hand in response to visual tool presentation and (ii) tool use demonstration with tool in hand in response to visual-tactile tool presentation. In both conditions, no physical target object was present. The conjunction analysis of the right and left hands executions of tool use pantomime relative to tool use demonstration yielded significant activity in the left middle and superior temporal lobe. In contrast, demonstration relative to pantomime revealed large bihemispherically distributed homologous areas of activity. Thus far, fMRI studies have demonstrated the relevance of the left middle and superior temporal gyri in viewing, naming, and matching tools and related actions and contexts. Since in our study all these factors were equally (ir)relevant both in the tool use pantomime and the tool use demonstration conditions, the present findings enhance the knowledge about the function of these brain regions in tool-related cognitive processes. The two contrasted conditions only differ regarding the fact that the pantomime condition requires the individual to act with an imaginary tool in hand. Therefore, we suggest that the left middle and superior temporal gyri are specifically involved in integrating the projected mental image of a tool in the execution of a tool-specific movement concept. (C) 2015 Elsevier Ltd. All rights reserved. KW - Tool use pantomime KW - Tool use demonstration KW - Mental image KW - Left middle and superior temporal gyri KW - Hemispheric specialization Y1 - 2015 SN - 0010-9452 SN - 1973-8102 VL - 71 SP - 1 EP - 14 PB - Elsevier CY - Milano ER - TY - JOUR A1 - Räling, Romy A1 - Holzgrefe-Lang, Julia A1 - Schröder, Astrid A1 - Wartenburger, Isabell T1 - On the influence of typicality and age of acquisition on semantic processing: Diverging evidence from behavioural and ERP responses JF - Neuropsychologia : an international journal in behavioural and cognitive neuroscience N2 - Various behavioural studies show that semantic typicality (TYP) and age of acquisition (AOA) of a specific word influence processing time and accuracy during the performance of lexical-semantic tasks. This study examines the influence of TYP and AOA on semantic processing at behavioural (response times and accuracy data) and electrophysiological levels using an auditory category-member-verification task. Reaction time data reveal independent TYP and AOA effects, while in the accuracy data and the event-related potentials predominantly effects of TYP can be found. The present study thus confirms previous findings and extends evidence found in the visual modality to the auditory modality. A modality-independent influence on semantic word processing is manifested. However, with regard to the influence of AOA, the diverging results raise questions on the origin of AOA effects as well as on the interpretation of offline and online data. Hence, results will be discussed against the background of recent theories on N400 correlates in semantic processing. In addition, an argument in favour of a complementary use of research techniques will be made. (C) 2015 Elsevier Ltd. All rights reserved. KW - Event-related potentials KW - N400 KW - Semantic typicality KW - Age of acquisition KW - Semantic priming KW - Category verification Y1 - 2015 U6 - https://doi.org/10.1016/j.neuropsychologia.2015.05.031 SN - 0028-3932 SN - 1873-3514 VL - 75 SP - 186 EP - 200 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Aktas, Maren A1 - Succow, Juliane A1 - Giel, Barbara A1 - Dressel, Katharina A1 - Lange, Inga A1 - Hanne, Sandra A1 - Burchert, Frank A1 - Vasishth, Shravan A1 - Schwytay, Jeannine A1 - Breitenstein, Sarah A1 - Fleischhauer, Elisabeth A1 - Baumann, Jeannine A1 - Preisinger, Irmhild A1 - Siegmüller, Julia A1 - Kuschmann, Anja A1 - Ebert, Susanne A1 - Lowit, Anja A1 - Rath, Elisa A1 - Heide, Judith A1 - Lorenz, Antje A1 - Wartenburger, Isabell A1 - Hippeli, Carolin A1 - Rausch, Monika A1 - Würzner, Kay-Michael A1 - Schroeder, Sascha A1 - Czapka, Sophia A1 - Klassert, Annegret A1 - Reuters, Sabine A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich A1 - Peiffers, Sabine A1 - Thonicke, Mady ED - Adelt, Anne ED - Otto, Constanze ED - Fritzsche, Tom ED - Magister, Caroline T1 - Spektrum Patholinguistik = Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder N2 - Das 8. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Besonders behandeln? Sprachtherapie im Rahmen primärer Störungsbilder" fand am 15.11.2014 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die vier Hauptvorträge zum Schwerpunktthema, die vier Kurzvorträge aus dem Spektrum Patholinguisitk sowie die Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eighth Autumn Meeting Patholinguistics ('Herbsttreffen Patholinguistik') with its main topic "Special treatment? Language therapy in the context of primary disorders" took place in Potsdam on November 15 2014. This annual meeting has been organized since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the four keynote talks on the main topic, the four short talks from the series 'Spectrum Patholinguistics', as well as the contributions of the poster session from all areas of speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 8 KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77147 SN - 978-3-86956-335-0 SN - 1869-3822 SN - 1866-9433 IS - 8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Rath, Elisa A1 - Heide, Judith A1 - Lorenz, Antje A1 - Wartenburger, Isabell T1 - Kompositaverarbeitung bei primär progressiver Aphasie BT - Eine Einzelfallstudie JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79821 SP - 151 EP - 171 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Gotzner, Nicole A1 - Wartenburger, Isabell A1 - Spalek, Katharina T1 - The impact of focus particles on the recognition and rejection of contrastive alternatives T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - The semantics of focus particles like only requires a set of alternatives (Rooth, 1992). In two experiments, we investigated the impact of such particles on the retrieval of alternatives that are mentioned in the prior context or unmentioned. The first experiment used a probe recognition task and showed that focus particles interfere with the recognition of mentioned alternatives and the rejection of unmentioned alternatives relative to a condition without a particle. A second lexical decision experiment demonstrated priming effects for mentioned and unmentioned alternatives (compared with an unrelated condition) while focus particles caused additional interference effects. Overall, our results indicate that focus particles trigger an active search for alternatives and lead to a competition between mentioned alternatives, unmentioned alternatives, and the focused element. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 517 KW - focus particles KW - alternative-set semantics KW - probe recognition task KW - lexical decision task KW - competitive inhibition Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-413420 SN - 1866-8364 IS - 517 ER - TY - JOUR A1 - Dix, Annika A1 - Wartenburger, Isabell A1 - van der Meer, Elke T1 - The role of fluid intelligence and learning in analogical reasoning: How to become neurally efficient? JF - Neurobiology of learning and memory N2 - This study on analogical reasoning evaluates the impact of fluid intelligence on adaptive changes in neural efficiency over the course of an experiment and specifies the underlying cognitive processes. Grade 10 students (N = 80) solved unfamiliar geometric analogy tasks of varying difficulty. Neural efficiency was measured by the event-related desynchronization (ERD) in the alpha band, an indicator of cortical activity. Neural efficiency was defined as a low amount of cortical activity accompanying high performance during problem-solving. Students solved the tasks faster and more accurately the higher their FI was. Moreover, while high FI led to greater cortical activity in the first half of the experiment, high FI was associated with a neurally more efficient processing (i.e., better performance but same amount of cortical activity) in the second half of the experiment. Performance in difficult tasks improved over the course of the experiment for all students while neural efficiency increased for students with higher but decreased for students with lower fluid intelligence. Based on analyses of the alpha sub-bands, we argue that high fluid intelligence was associated with a stronger investment of attentional resource in the integration of information and the encoding of relations in this unfamiliar task in the first half of the experiment (lower-2 alpha band). Students with lower fluid intelligence seem to adapt their applied strategies over the course of the experiment (i.e., focusing on task-relevant information; lower-1 alpha band). Thus, the initially lower cortical activity and its increase in students with lower fluid intelligence might reflect the overcoming of mental overload that was present in the first half of the experiment. (C) 2016 Elsevier Inc. All rights reserved. KW - Analogical reasoning KW - Short-term learning KW - Fluid intelligence KW - Neural efficiency KW - Alpha ERD/ERS Y1 - 2016 U6 - https://doi.org/10.1016/j.nlm.2016.07.019 SN - 1074-7427 SN - 1095-9564 VL - 134 SP - 236 EP - 247 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Holzgrefe-Lang, Julia A1 - Wellmann, Caroline A1 - Petrone, Caterina A1 - Raeling, Romy A1 - Truckenbrodt, Hubert A1 - Höhle, Barbara A1 - Wartenburger, Isabell T1 - How pitch change and final lengthening cue boundary perception in German: converging evidence from ERPs and prosodic judgements JF - Language, cognition and neuroscience N2 - This study examines the role of pitch and final lengthening in German intonation phrase boundary (IPB) perception. Since a prosody-related event-related potential (ERP) component termed Closure Positive Shift reflects the processing of major prosodic boundaries, we combined ERP and behavioural measures (i.e. a prosodic judgement task) to systematically test the impact of sole and combined cue occurrences on IPB perception. In two experiments we investigated whether adult listeners perceived an IPB in acoustically manipulated speech material that contained none, one, or two of the prosodic boundary cues. Both ERP and behavioural results suggest that pitch and final lengthening cues have to occur in combination to trigger IPB perception. Hence, the combination of behavioural and electrophysiological measures provides a comprehensive insight into prosodic boundary cue perception in German and leads to an argument in favour of interrelated cues from the frequency (i.e. pitch change) and the time (i.e. final lengthening) domain. KW - Speech perception KW - prosody KW - Event-Related Potential (ERP) technique KW - Closure Positive Shift (CPS) KW - prosodic boundary cues Y1 - 2016 U6 - https://doi.org/10.1080/23273798.2016.1157195 SN - 2327-3798 SN - 2327-3801 VL - 31 SP - 904 EP - 920 PB - Begell House CY - Abingdon ER - TY - JOUR A1 - Räling, Romy A1 - Schröder, Astrid A1 - Wartenburger, Isabell T1 - The origins of age of acquisition and typicality effects: Semantic processing in aphasia and the ageing brain JF - Neuropsychologia : an international journal in behavioural and cognitive neuroscience N2 - Age of acquisition (AOA) has frequently been shown to influence response times and accuracy rates in word processing and constitutes a meaningful variable in aphasic language processing, while its origin in the language processing system is still under debate. To find out where AOA originates and whether and how it is related to another important psycholinguistic variable, namely semantic typicality (TYP), we studied healthy, elderly controls and semantically impaired individuals using semantic priming. For this purpose, we collected reaction times and accuracy rates as well as event-related potential data in an auditory category-member-verification task. The present results confirm a semantic origin of TYP, but question the same for AOA while favouring its origin at the phonology-semantics interface. The data are further interpreted in consideration of recent theories of ageing. (C) 2016 Elsevier Ltd. All rights reserved. KW - Ageing KW - Aphasia KW - N400 KW - Semantic typicality KW - Age of acquisition Y1 - 2016 U6 - https://doi.org/10.1016/j.neuropsychologia.2016.04.019 SN - 0028-3932 SN - 1873-3514 VL - 86 SP - 80 EP - 92 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Gotzner, Nicole A1 - Wartenburger, Isabell A1 - Spalek, Katharina T1 - The impact of focus particles on the recognition and rejection of contrastive alternatives JF - Language and cognition : an interdisciplinary journal of language and cognitive science N2 - The semantics of focus particles like only requires a set of alternatives (Rooth, 1992). In two experiments, we investigated the impact of such particles on the retrieval of alternatives that are mentioned in the prior context or unmentioned. The first experiment used a probe recognition task and showed that focus particles interfere with the recognition of mentioned alternatives and the rejection of unmentioned alternatives relative to a condition without a particle. A second lexical decision experiment demonstrated priming effects for mentioned and unmentioned alternatives (compared with an unrelated condition) while focus particles caused additional interference effects. Overall, our results indicate that focus particles trigger an active search for alternatives and lead to a competition between mentioned alternatives, unmentioned alternatives, and the focused element. KW - focus particles KW - alternative-set semantics KW - probe recognition task KW - lexical decision task KW - competitive inhibition Y1 - 2016 U6 - https://doi.org/10.1017/langcog.2015.25 SN - 1866-9808 SN - 1866-9859 VL - 8 SP - 59 EP - 95 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Zakariás, Lilla A1 - Keresztes, Attila A1 - Marton, Klara A1 - Wartenburger, Isabell T1 - Positive effects of a computerised working memory and executive function JF - Neuropsychological rehabilitation N2 - Aphasia, the language disorder following brain damage, is frequently accompanied by deficits of working memory (WM) and executive functions (EFs). Recent studies suggest that WM, together with certain EFs, can play a role in sentence comprehension in individuals with aphasia (IWA), and that WM can be enhanced with intensive practice. Our aim was to investigate whether a combined WM and EF training improves the understanding of spoken sentences in IWA. We used a pre-post-test case control design. Three individuals with chronic aphasia practised an adaptive training task (a modified n-back task) three to four times a week for a month. Their performance was assessed before and after the training on outcome measures related to WM and spoken sentence comprehension. One participant showed significant improvement on the training task, another showed a tendency for improvement, and both of them improved significantly in spoken sentence comprehension. The third participant did not improve on the training task, however, she showed improvement on one measure of spoken sentence comprehension. Compared to controls, two individuals improved at least in one condition of the WM outcome measures. Thus, our results suggest that a combined WM and EF training can be beneficial for IWA. KW - Aphasia rehabilitation KW - transfer effect KW - updating training KW - interference control KW - sentence comprehension deficit Y1 - 2016 U6 - https://doi.org/10.1080/09602011.2016.1159579 SN - 0960-2011 SN - 1464-0694 VL - 28 IS - 3 SP - 369 EP - 386 PB - Routledge, Taylor & Francis Group CY - Abingdon ER -