TY - JOUR A1 - Beerenwinkel, Niko A1 - Sing, Tobias A1 - Lengauer, Thomas A1 - Rahnenfuhrer, Joerg A1 - Roomp, Kirsten A1 - Savenkov, Igor A1 - Fischer, Roman A1 - Hoffmann, Daniel A1 - Selbig, Joachim A1 - Korn, Klaus A1 - Walter, Hauke A1 - Berg, Thomas A1 - Braun, Patrick A1 - Faetkenheuer, Gerd A1 - Oette, Mark A1 - Rockstroh, Juergen A1 - Kupfer, Bernd A1 - Kaiser, Rolf A1 - Daeumer, Martin T1 - Computational methods for the design of effective therapies against drug resistant HIV strains N2 - The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data Y1 - 2005 ER -