TY  - JOUR
A1  - Duydu, Yalcin
A1  - Basaran, Nursen
A1  - Yalcin, Can Özgür
A1  - Ustundag, Aylin
A1  - Aydin, Sevtap
A1  - Anlar, Hatice Gul
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Bolt, Hermann M.
T1  - Boron-exposed male workers in Turkey
BT  - no change in sperm Y:X chromosome ratio and in offspring's sex ratio
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.
KW  - Paternal exposure
KW  - Boron exposure
KW  - Y:X chromosome ratio
KW  - Sex ratio at birth
Y1  - 2019
U6  - https://doi.org/10.1007/s00204-019-02391-z
SN  - 0340-5761
SN  - 1432-0738
VL  - 93
IS  - 3
SP  - 743
EP  - 751
PB  - Springer
CY  - Heidelberg
ER  -