TY  - JOUR
A1  - Nickerson, David
A1  - Atalag, Koray
A1  - de Bono, Bernard
A1  - Geiger, Joerg
A1  - Goble, Carole
A1  - Hollmann, Susanne
A1  - Lonien, Joachim
A1  - Mueller, Wolfgang
A1  - Regierer, Babette
A1  - Stanford, Natalie J.
A1  - Golebiewski, Martin
A1  - Hunter, Peter
T1  - The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable
JF  - Interface focus
N2  - Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome.
KW  - Human Physiome
KW  - standards
KW  - repositories
KW  - service infrastructure
KW  - reproducible science
KW  - managing big data
Y1  - 2016
U6  - https://doi.org/10.1098/rsfs.2015.0103
SN  - 2042-8898
SN  - 2042-8901
VL  - 6
SP  - 57
EP  - 61
PB  - Royal Society
CY  - London
ER  -