TY - JOUR A1 - Mota, Simon A1 - Leckelt, Marius A1 - Geukes, Katharina A1 - Nestler, Steffen A1 - Humberg, Sarah A1 - Schröder-Abe, Michela A1 - Schmukle, Stefan C. A1 - Back, Mitja D. T1 - A comprehensive examination of narcissists’ self-perceived and actual socioemotional cognition ability JF - Collabra: Psychology N2 - Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed. KW - narcissism KW - socioemotional cognition KW - self-perceived ability KW - actual ability KW - empathy KW - emotional intelligence KW - self-enhancement Y1 - 2018 U6 - https://doi.org/10.1525/collabra.174 SN - 2474-7394 VL - 5 IS - 1 PB - University of California Press CY - Oakland ER - TY - JOUR A1 - Risbey, James S. A1 - Lewandowsky, Stephan A1 - Cowtan, Kevin A1 - Oreskes, Naomi A1 - Rahmstorf, Stefan A1 - Jokimäki, Ari A1 - Foster, Grant T1 - A fluctuation in surface temperature in historical context BT - reassessment and retrospective on the evidence JF - Environmental research letters N2 - This work reviews the literature on an alleged global warming 'pause' in global mean surface temperature (GMST) to determine how it has been defined, what time intervals are used to characterise it, what data are used to measure it, and what methods used to assess it. We test for 'pauses', both in the normally understood meaning of the term to mean no warming trend, as well as for a 'pause' defined as a substantially slower trend in GMST. The tests are carried out with the historical versions of GMST that existed for each pause-interval tested, and with current versions of each of the GMST datasets. The tests are conducted following the common (but questionable) practice of breaking the linear fit at the start of the trend interval ('broken' trends), and also with trends that are continuous with the data bordering the trend interval. We also compare results when appropriate allowance is made for the selection bias problem. The results show that there is little or no statistical evidence for a lack of trend or slower trend in GMST using either the historical data or the current data. The perception that there was a 'pause' in GMST was bolstered by earlier biases in the data in combination with incomplete statistical testing. KW - climate variability KW - climate trends KW - temperature fluctuation KW - pause hiatus Y1 - 2018 U6 - https://doi.org/10.1088/1748-9326/aaf342 SN - 1748-9326 VL - 13 IS - 12 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Gao, Yongbo A1 - Merz, Christoph A1 - Lischeid, Gunnar A1 - Schneider, Michael T1 - A review on missing hydrological data processing JF - Environmental earth sciences N2 - Like almost all fields of science, hydrology has benefited to a large extent from the tremendous improvements in scientific instruments that are able to collect long-time data series and an increase in available computational power and storage capabilities over the last decades. Many model applications and statistical analyses (e.g., extreme value analysis) are based on these time series. Consequently, the quality and the completeness of these time series are essential. Preprocessing of raw data sets by filling data gaps is thus a necessary procedure. Several interpolation techniques with different complexity are available ranging from rather simple to extremely challenging approaches. In this paper, various imputation methods available to the hydrological researchers are reviewed with regard to their suitability for filling gaps in the context of solving hydrological questions. The methodological approaches include arithmetic mean imputation, principal component analysis, regression-based methods and multiple imputation methods. In particular, autoregressive conditional heteroscedasticity (ARCH) models which originate from finance and econometrics will be discussed regarding their applicability to data series characterized by non-constant volatility and heteroscedasticity in hydrological contexts. The review shows that methodological advances driven by other fields of research bear relevance for a more intensive use of these methods in hydrology. Up to now, the hydrological community has paid little attention to the imputation ability of time series models in general and ARCH models in particular. KW - Missing data KW - Imputation KW - Hydrological time series analysis KW - ARCH KW - ARIMA KW - Heteroscedasticity Y1 - 2018 U6 - https://doi.org/10.1007/s12665-018-7228-6 SN - 1866-6280 SN - 1866-6299 VL - 77 IS - 2 PB - Springer CY - New York ER - TY - JOUR A1 - Antonietti, Markus A1 - Lopez-Salas, Nieves A1 - Primo, Ana T1 - Adjusting the Structure and Electronic Properties of Carbons for Metal-Free Carbocatalysis of Organic Transformations JF - Advanced materials N2 - Carbon nanomaterials doped with some other lightweight elements were recently described as powerful, heterogeneous, metal-free organocatalysts, adding to their high performance in electrocatalysis. Here, recent observations in traditional catalysis are reviewed, and the underlying reaction mechanisms of the catalyzed organic transformations are explored. In some cases, these are due to specific active functional sites, but more generally the catalytic activity relates to collective properties of the conjugated nanocarbon frameworks and the electron transfer from and to the catalytic centers and substrates. It is shown that the !earnings are tightly related to those of electrocatalysis; i.e., the search for better electrocatalysts also improves chemocatalysis, and vice versa. Carbon-carbon heterojunction effects and some perspectives on future possibilities are discussed at the end. KW - active sites KW - carbocatalysis KW - carbon electrical collective properties KW - metal-free KW - nanocarbon materials Y1 - 2018 U6 - https://doi.org/10.1002/adma.201805719 SN - 0935-9648 SN - 1521-4095 VL - 31 IS - 13 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Basler, Georg A1 - Fernie, Alisdair R. A1 - Nikoloski, Zoran T1 - Advances in metabolic flux analysis toward genome-scale profiling of higher organisms JF - Bioscience reports : communications and reviews in molecular and cellular biology N2 - Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies. Y1 - 2018 U6 - https://doi.org/10.1042/BSR20170224 SN - 0144-8463 SN - 1573-4935 VL - 38 PB - Portland Press (London) CY - London ER - TY - JOUR A1 - Randall, Matthew J. A1 - Jüngel, Astrid A1 - Rimann, Markus A1 - Wuertz-Kozak, Karin T1 - Advances in the biofabrication of 3D Skin in vitro BT - healthy and pathological models JF - Frontiers in Bioengineeringand Biotechnology N2 - The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation. Y1 - 2018 U6 - https://doi.org/10.3389/fbioe.2018.00154 SN - 2296-4185 VL - 6 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Reich, Tamar Chana T1 - Alon Goshen-Gottstein: The Jewish Encounter with Hinduism: Wisdom, Spirituality, Identity / Same God, Other God: Judaism, Hinduism and the Problem of Idolatry /rezensiert von Tamar Chana Reich JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien [23 (2017)] = JewBus, Jewish Hindus & other Jewish Encounters with East Asian Religions JF - PaRDeS : Journal of the Association of Jewish Studies [23 (2017)] = JewBus, Jewish Hindus & other Jewish Encounters with East Asian Religions N2 - Alon Goshen-Gottstein: The Jewish Encounter with Hinduism: Wisdom, Spirituality, Identity (Interreligious Studies in Theory and Practice series), New York: Palgrave, Macmillan 2016, IX, 275 S. Alon Goshen-Gottstein: Same God, Other God: Judaism, Hinduism and the Problem of Idolatry (Interreligious Studies in Theory and Practice series), New York: Palgrave, Macmillan 2016. X, 265 S. Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-409041 SN - 978-3-86956-418-0 SN - 1614-6492 SN - 1862-7684 IS - 23 SP - 214 EP - 218 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Heck, Christian A1 - Michaeli, Yael A1 - Bald, Ilko A1 - Ebenstein, Yuval T1 - Analytical epigenetics BT - single-molecule optical detection of DNA and histone modifications JF - Current Opinion in Biotechnology N2 - The field of epigenetics describes the relationship between genotype and phenotype, by regulating gene expression without changing the canonical base sequence of DNA. It deals with molecular genomic information that is encoded by a rich repertoire of chemical modifications and molecular interactions. This regulation involves DNA, RNA and proteins that are enzymatically tagged with small molecular groups that alter their physical and chemical properties. It is now clear that epigenetic alterations are involved in development and disease, and thus, are the focus of intensive research. The ability to record epigenetic changes and quantify them in rare medical samples is critical for next generation diagnostics. Optical detection offers the ultimate single-molecule sensitivity and the potential for spectral multiplexing. Here we review recent progress in ultrasensitive optical detection of DNA and histone modifications. Y1 - 2018 U6 - https://doi.org/10.1016/j.copbio.2018.09.006 SN - 0958-1669 SN - 1879-0429 VL - 55 SP - 151 EP - 158 PB - Elsevier CY - London ER - TY - JOUR A1 - Civitillo, Sauro A1 - Juang, Linda P. A1 - Schachner, Maja Katharina T1 - Challenging beliefs about cultural diversity in education BT - a synthesis and critical review of trainings with pre-service teachers JF - Educational Research Review N2 - Teaching culturally diverse classrooms starts from embracing beliefs that recognise the strengths of cultural diversity. Research is needed to understand how teacher training contributes to shaping pre-service teachers’ beliefs about cultural diversity. Accordingly, the purpose of this review is to 1) provide a description of main components and contextual characteristics of teacher trainings targeting cultural diversity beliefs, 2) report the training effects, and 3) detail the methodological strengths and weaknesses of these studies. A total of 36 studies published between 2005 and 2015 that used a longitudinal assessment of cultural diversity beliefs were reviewed. The collective results of these studies indicate a large variance amongst trainings, with experiential learning shifting cultural diversity beliefs positively. However, existing studies have significant limitations in the study design and training evaluation that hinder their conclusions regarding internal and external validity and point towards new directions for future research. KW - Cultural diversity KW - Beliefs KW - Teacher education KW - Pre-service teacher Y1 - 2018 U6 - https://doi.org/10.1016/j.edurev.2018.01.003 SN - 1747-938X SN - 1878-0385 VL - 24 SP - 67 EP - 83 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Friedrich, Thomas A1 - Faivre, Lea A1 - Bäurle-Lenhard, Isabel A1 - Schubert, Daniel T1 - Chromatin-based mechanisms of temperature memory in plants JF - Plant, cell & environment : cell physiology, whole-plant physiology, community physiology N2 - For successful growth and development, plants constantly have to gauge their environment. Plants are capable to monitor their current environmental conditions, and they are also able to integrate environmental conditions over time and store the information induced by the cues. In a developmental context, such an environmental memory is used to align developmental transitions with favourable environmental conditions. One temperature-related example of this is the transition to flowering after experiencing winter conditions, that is, vernalization. In the context of adaptation to stress, such an environmental memory is used to improve stress adaptation even when the stress cues are intermittent. A somatic stress memory has now been described for various stresses, including extreme temperatures, drought, and pathogen infection. At the molecular level, such a memory of the environment is often mediated by epigenetic and chromatin modifications. Histone modifications in particular play an important role. In this review, we will discuss and compare different types of temperature memory and the histone modifications, as well as the reader, writer, and eraser proteins involved. KW - chromatin KW - cold KW - epigenetics KW - heat KW - memory KW - nucleosome remodelling KW - polycomb KW - priming KW - trithorax Y1 - 2018 U6 - https://doi.org/10.1111/pce.13373 SN - 0140-7791 SN - 1365-3040 VL - 42 IS - 3 SP - 762 EP - 770 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Arias-Andres, Maria A1 - Rojas-Jimenez, Keilor A1 - Grossart, Hans-Peter T1 - Collateral effects of microplastic pollution on aquatic microorganisms BT - An ecological perspective JF - Trends in Analytical Chemistry N2 - Microplastics (MP) provide a unique and extensive surface for microbial colonization in aquatic ecosystems. The formation of microorganism-microplastic complexes, such as biofilms, maximizes the degradation of organic matter and horizontal gene transfer. In this context, MP affect the structure and function of microbial communities, which in turn render the physical and chemical fate of MP. This new paradigm generates challenges for microbiology, ecology, and ecotoxicology. Dispersal of MP is concomitant with that of their associated microorganisms and their mobile genetic elements, including antibiotic resistance genes, islands of pathogenicity, and diverse metabolic pathways. Functional changes in aquatic microbiomes can alter carbon metabolism and food webs, with unknown consequences on higher organisms or human microbiomes and hence health. Here, we examine a variety of effects of MP pollution from the microbial ecology perspective, whose repercussions on aquatic ecosystems begin to be unraveled. (C) 2018 Elsevier B.V. All rights reserved. KW - Microplastics (MP) KW - Biofilms KW - HGT KW - Microbial ecology KW - Carbon cycling KW - Aquatic ecosystems KW - Health risk assessment Y1 - 2018 U6 - https://doi.org/10.1016/j.trac.2018.11.041 SN - 0165-9936 SN - 1879-3142 VL - 112 SP - 234 EP - 240 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Ladwig, Simon A1 - Zhou, Zien A1 - Xu, Ying A1 - Wang, Xia A1 - Chow, Clara K. A1 - Werheid, Katja A1 - Hackett, Maree L. T1 - Comparison of treatment rates of depression after stroke versus myocardial infarction BT - a systematic review and meta-analysis of observational data JF - Psychosomatic medicine N2 - Objective Depression after stroke and myocardial infarction (MI) is common but often assumed to be undertreated without reliable evidence being available. Thus, we aimed to determine treatment rates and investigate the application of guidelines in these conditions. Methods Databases MEDLINE, EMBASE, PsycInfo, Web of Science, CINAHL, and Scopus were systematically searched without language restriction from inception to June 30, 2017. Prospective observational studies with consecutive recruitment reporting any antidepressant treatment in adults with depression after stroke or MI were included. Random-effects models were used to calculate pooled estimates of treatment rates. Results Fifty-five studies reported 32 stroke cohorts (n = 8938; pooled frequency of depression = 34%, 95% confidence interval [CI] = 29%-38%) and 17 MI cohorts (n = 10,767; pooled frequency of depression = 24%, 95% CI = 20%-28%). In 29 stroke cohorts, 24% (95% CI = 20%-27%) of 2280 depressed people used antidepressant medication. In 15 MI cohorts, 14% (95% CI = 8%-19%) of 2381 depressed people used antidepressant medication indicating a lower treatment rate than in stroke. Two studies reported use of psychosocial interventions, indicating that less than 10% of participants were treated. Conclusions Despite the high frequency of depression after stroke and MI and the existence of efficacious treatment strategies, people often remain untreated. Innovative strategies are needed to increase the use of effective antidepressive interventions in patients with cardiovascular disease. KW - depression KW - myocardial infarction KW - pharmacoepidemiology KW - stroke KW - treatment Y1 - 2018 U6 - https://doi.org/10.1097/PSY.0000000000000632 SN - 0033-3174 SN - 1534-7796 VL - 80 IS - 8 SP - 754 EP - 763 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Mota, Cristiano A1 - Coelho, Catarina A1 - Leimkühler, Silke A1 - Garattini, Enrico A1 - Terao, Mineko A1 - Santos-Silva, Teresa A1 - Romao, Maria Joao T1 - Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics JF - Coordination chemistry reviews N2 - Aldehyde oxidases are molybdenum and flavin dependent enzymes characterized by a very wide substrate specificity and performing diverse reactions that include oxidations (e.g., aldehydes and azaheterocycles), hydrolysis of amide bonds, and reductions (e.g., nitro, S-oxides and N-oxides). Oxidation reactions and amide hydrolysis occur at the molybdenum site while the reductions are proposed to occur at the flavin site. AOX activity affects the metabolism of different drugs and xenobiotics, some of which designed to resist other liver metabolizing enzymes (e.g., cytochrome P450 monooxygenase isoenzymes), raising its importance in drug development. This work consists of a comprehensive overview on aldehyde oxidases, concerning the genetic evolution of AOX, its diversity among the human population, the crystal structures available, the known catalytic reactions and the consequences in pre-clinical pharmacokinetic and pharmacodynamic studies. Analysis of the different animal models generally used for pre-clinical trials and comparison between the human (hAOX1), mouse homologs as well as the related xanthine oxidase (XOR) are extensively considered. The data reviewed also include a systematic analysis of representative classes of molecules that are hAOX1 substrates as well as of typical and well characterized hAOX1 inhibitors. The considerations made on the basis of a structural and functional analysis are correlated with reported kinetic and metabolic data for typical classes of drugs, searching for potential structural determinants that may dictate substrate and/or inhibitor specificities. KW - Drug metabolism KW - Aldehyde oxidase KW - Xenobiotics KW - Molybdoenzymes KW - Non-CYP enzymes KW - Hepatic clearance Y1 - 2018 U6 - https://doi.org/10.1016/j.ccr.2018.04.006 SN - 0010-8545 SN - 1873-3840 VL - 368 SP - 35 EP - 59 PB - Elsevier CY - Lausanne ER - TY - JOUR A1 - Ayllon, Daniel A1 - Grimm, Volker A1 - Attinger, Sabine A1 - Hauhs, Michael A1 - Simmer, Clemens A1 - Vereecken, Harry A1 - Lischeid, Gunnar T1 - Cross-disciplinary links in environmental systems science BT - Current state and claimed needs identified in a meta-review of process models JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man N2 - Terrestrial environmental systems are characterised by numerous feedback links between their different compartments. However, scientific research is organized into disciplines that focus on processes within the respective compartments rather than on interdisciplinary links. Major feedback mechanisms between compartments might therefore have been systematically overlooked so far. Without identifying these gaps, initiatives on future comprehensive environmental monitoring schemes and experimental platforms might fail. We performed a comprehensive overview of feedbacks between compartments currently represented in environmental sciences and explores to what degree missing links have already been acknowledged in the literature. We focused on process models as they can be regarded as repositories of scientific knowledge that compile findings of numerous single studies. In total, 118 simulation models from 23 model types were analysed. Missing processes linking different environmental compartments were identified based on a meta-review of 346 published reviews, model inter-comparison studies, and model descriptions. Eight disciplines of environmental sciences were considered and 396 linking processes were identified and ascribed to the physical, chemical or biological domain. There were significant differences between model types and scientific disciplines regarding implemented interdisciplinary links. The most wide-spread interdisciplinary links were between physical processes in meteorology, hydrology and soil science that drive or set the boundary conditions for other processes (e.g., ecological processes). In contrast, most chemical and biological processes were restricted to links within the same compartment. Integration of multiple environmental compartments and interdisciplinary knowledge was scarce in most model types. There was a strong bias of suggested future research foci and model extensions towards reinforcing existing interdisciplinary knowledge rather than to open up new interdisciplinary pathways. No clear pattern across disciplines exists with respect to suggested future research efforts. There is no evidence that environmental research would clearly converge towards more integrated approaches or towards an overarching environmental systems theory. (c) 2017 Elsevier B.V. All rights reserved. KW - Review KW - Interdisciplinary links KW - Integrated environmental modelling KW - Research needs Y1 - 2018 U6 - https://doi.org/10.1016/j.scitotenv.2017.12.007 SN - 0048-9697 SN - 1879-1026 VL - 622 SP - 954 EP - 973 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kleuser, Burkhard T1 - Divergent role of sphingosine 1-phosphate in liver health and disease JF - International journal of molecular sciences N2 - Two decades ago, sphingosine 1-phosphate (S1P) was discovered as a novel bioactive molecule that regulates a variety of cellular functions. The plethora of S1P-mediated effects is due to the fact that the sphingolipid not only modulates intracellular functions but also acts as a ligand of G protein-coupled receptors after secretion into the extracellular environment. In the plasma, S1P is found in high concentrations, modulating immune cell trafficking and vascular endothelial integrity. The liver is engaged in modulating the plasma S1P content, as it produces apolipoprotein M, which is a chaperone for the S1P transport. Moreover, the liver plays a substantial role in glucose and lipid homeostasis. A dysfunction of glucose and lipid metabolism is connected with the development of liver diseases such as hepatic insulin resistance, non-alcoholic fatty liver disease, or liver fibrosis. Recent studies indicate that S1P is involved in liver pathophysiology and contributes to the development of liver diseases. In this review, the current state of knowledge about S1P and its signaling in the liver is summarized with a specific focus on the dysregulation of S1P signaling in obesity-mediated liver diseases. Thus, the modulation of S1P signaling can be considered as a potential therapeutic target for the treatment of hepatic diseases. KW - sphingolipids KW - sphingosine kinase KW - fibrosis KW - non-alcoholic fatty liver disease KW - insulin resistance KW - liver fibrosis Y1 - 2018 U6 - https://doi.org/10.3390/ijms19030722 SN - 1422-0067 VL - 19 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Szalay, J. R. A1 - Poppe, A. R. A1 - Agarwal, J. A1 - Britt, D. A1 - Belskaya, I. A1 - Horanyi, M. A1 - Nakamura, T. A1 - Sachse, M. A1 - Spahn, Frank T1 - Dust Phenomena Relating to Airless Bodies JF - Space science reviews N2 - Airless bodies are directly exposed to ambient plasma and meteoroid fluxes, making them characteristically different from bodies whose dense atmospheres protect their surfaces from such fluxes. Direct exposure to plasma and meteoroids has important consequences for the formation and evolution of planetary surfaces, including altering chemical makeup and optical properties, generating neutral gas and/or dust exospheres, and leading to the generation of circumplanetary and interplanetary dust grain populations. In the past two decades, there have been many advancements in our understanding of airless bodies and their interaction with various dust populations. In this paper, we describe relevant dust phenomena on the surface and in the vicinity of airless bodies over a broad range of scale sizes from to , with a focus on recent developments in this field. KW - Dust KW - Airless bodies KW - Interplanetary dust Y1 - 2018 U6 - https://doi.org/10.1007/s11214-018-0527-0 SN - 0038-6308 SN - 1572-9672 VL - 214 IS - 5 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Weisshuhn, Peter A1 - Mueller, Felix A1 - Wiggering, Hubert T1 - Ecosystem Vulnerability Review BT - proposal of an interdisciplinary ecosystem assessment approach JF - Environmental Management N2 - To safeguard the sustainable use of ecosystems and their services, early detection of potentially damaging changes in functional capabilities is needed. To support a proper ecosystem management, the analysis of an ecosystem’s vulnerability provide information on its weaknesses as well as on its capacity to recover after suffering an impact. However, the application of the vulnerability concept to ecosystems is still an emerging topic. After providing background on the vulnerability concept, we summarize existing ecosystem vulnerability research on the basis of a systematic literature review with a special focus on ecosystem type, disciplinary background, and more detailed definition of the ecosystem vulnerability components. Using the Web of ScienceTM Core Collection, we overviewed the literature from 1991 onwards but used the 5 years from 2011 to 2015 for an in-depth analysis, including 129 articles. We found that ecosystem vulnerability analysis has been applied most notably in conservation biology, climate change research, and ecological risk assessments, pinpointing a limited spreading across the environmental sciences. It occurred primarily within marine and freshwater ecosystems. To avoid confusion, we recommend using the unambiguous term ecosystem vulnerability rather than ecological, environmental, population, or community vulnerability. Further, common ground has been identified, on which to define the ecosystem vulnerability components exposure, sensitivity, and adaptive capacity. We propose a framework for ecosystem assessments that coherently connects the concepts of vulnerability, resilience, and adaptability as different ecosystem responses. A short outlook on the possible operationalization of the concept by ecosystem vulnerabilty indices, and a conclusion section complete the review. KW - Environmental vulnerability KW - Ecological vulnerability KW - Ecosystem response KW - Interdisciplinarity KW - Resilience KW - Adaptability Y1 - 2018 U6 - https://doi.org/10.1007/s00267-018-1023-8 SN - 0364-152X SN - 1432-1009 VL - 61 IS - 6 SP - 904 EP - 915 PB - Springer CY - New York ER - TY - JOUR A1 - Gebel, Arnd A1 - Lesinski, Melanie A1 - Behm, David George A1 - Granacher, Urs T1 - Effects and dose-response relationship of balance training on balance performance in Youth BT - a systematic review and meta-analysis JF - Sports medicine N2 - Background Effects and dose-response relationships of balance training on measures of balance are well-documented for healthy young and old adults. However, this has not been systematically studied in youth. Objectives The objectives of this systematic review and meta-analysis were to quantify effects of balance training (BT) on measures of static and dynamic balance in healthy children and adolescents. Additionally, dose-response relations for BT modalities (e.g. training period, frequency, volume) were quantified through the analysis of controlled trials. Data Sources A computerized systematic literature search was conducted in the electronic databases PubMed and Web of Science from January 1986 until June 2017 to identify articles related to BT in healthy trained and untrained children and adolescents. Study Eligibility Criteria A systematic approach was used to evaluate articles that examined the effects of BT on balance outcomes in youth. Controlled trials with pre- and post-measures were included if they examined healthy youth with a mean age of 6-19 years and assessed at least one measure of balance (i.e. static/dynamic steady-state balance, reactive balance, proactive balance) with behavioural (e.g. time during single-leg stance) or biomechanical (e.g. centre of pressure displacements during single-leg stance) test methods. Study Appraisal and Synthesis Methods The included studies were coded for the following criteria: training modalities (i.e. training period, frequency, volume), balance outcomes (i.e. static and dynamic balance) as well as chronological age, sex (male vs. female), training status (trained vs. untrained), setting (school vs. club), and testing method (biomechanical vs. physical fitness test). Weighted mean standardized mean differences (SMDwm) were calculated using a random-effects model to compute overall intervention effects relative to active and passive control groups. Between-study heterogeneity was assessed using I 2 and chi(2) statistics. A multivariate random effects meta-regression was computed to explain the influence of key training modalities (i.e. training period, training frequency, total number of training sessions, duration of training sessions, and total duration of training per week) on the effectiveness of BT on measures of balance performance. Further, subgroup univariate analyses were computed for each training modality. Additionally, dose-response relationships were characterized independently by interpreting the modality specific magnitude of effect sizes. Methodological quality of the included studies was rated with the help of the Physiotherapy Evidence Database (PEDro) Scale. Results Overall, our literature search revealed 198 hits of which 17 studies were eligible for inclusion in this systematic review and meta-analysis. Irrespective of age, sex, training status, sport discipline and training method, moderate to large BT-related effects were found for measures of static (SMDwm = 0.71) and dynamic (SMDwm = 1.03) balance in youth. However, our subgroup analyses did not reveal any statistically significant effects of the moderator variables age, sex, training status, setting and testing method on overall balance (i.e. aggregation of static and dynamic balance). BT-related effects in adolescents were moderate to large for measures of static (SMDwm = 0.61) and dynamic (SMDwm = 0.86) balance. With regard to the dose-response relationships, findings from the multivariate random effects meta-regression revealed that none of the examined training modalities predicted the effects of BT on balance performance in adolescents (R-2 = 0.00). In addition, results from univariate analysis have to be interpreted with caution because training modalities were computed as single factors irrespective of potential between-modality interactions. For training period, 12 weeks of training achieved the largest effect (SMDwm = 1.40). For training frequency, the largest effect was found for two sessions per week (SMDwm = 1.29). For total number of training sessions, the largest effect was observed for 24-36 sessions (SMDwm = 1.58). For the modality duration of a single training session, 4-15 min reached the largest effect (SMDwm = 1.03). Finally, for the modality training per week, a total duration of 31-60 min per week (SMDwm = 1.33) provided the largest effects on overall balance in adolescents. Methodological quality of the studies was rated as moderate with a median PEDro score of 6.0. Limitations Dose-response relationships were calculated independently for training modalities (i.e. modality specific) and not interdependently. Training intensity was not considered for the calculation of dose-response relationships because the included studies did not report this training modality. Further, the number of included studies allowed the characterization of dose-response relationships in adolescents for overall balance only. In addition, our analyses revealed a considerable between-study heterogeneity (I-2 = 66-83%). The results of this meta-analysis have to be interpreted with caution due to their preliminary status. Conclusions BT is a highly effective means to improve balance performance with moderate to large effects on static and dynamic balance in healthy youth irrespective of age, sex, training status, setting and testing method. The examined training modalities did not have a moderating effect on balance performance in healthy adolescents. Thus, we conclude that an additional but so far unidentified training modality may have a major effect on balance performance that was not assessed in our analysis. Training intensity could be a promising candidate. However, future studies are needed to find appropriate methods to assess BT intensity. Y1 - 2018 U6 - https://doi.org/10.1007/s40279-018-0926-0 SN - 0112-1642 SN - 1179-2035 VL - 48 IS - 9 SP - 2067 EP - 2089 PB - Springer CY - Northcote ER - TY - JOUR A1 - Moran, Jason A1 - Ramirez-Campillo, Rodrigo A1 - Granacher, Urs T1 - Effects of Jumping Exercise on Muscular Power in Older Adults BT - a Meta-Analysis JF - Sports medicine N2 - Background Jump training (JT) can be used to enhance the ability of skeletal muscle to exert maximal force in as short a time as possible. Despite its usefulness as a method of performance enhancement in athletes, only a small number of studies have investigated its effects on muscle power in older adults. Objectives The aims of this meta-analysis were to measure the effect of JT on muscular power in older adults (≥ 50 years), and to establish appropriate programming guidelines for this population. Data Sources The data sources utilised were Google Scholar, PubMed, and Microsoft Academic. Study Eligibility Criteria Studies were eligible for inclusion if they comprised JT interventions in healthy adults (≥ 50 years) who were free of any medical condition that could impair movement. Study Appraisal and Synthesis Methods The inverse variance random-effects model for meta-analyses was used because it allocates a proportionate weight to trials based on the size of their individual standard errors and facilitates analysis while accounting for heterogeneity across studies. Effect sizes (ESs), calculated from a measure of muscular power, were represented by the standardised mean difference and were presented alongside 95% confidence intervals (CIs). Results Thirteen training groups across nine studies were included in this meta-analysis. The magnitude of the main effect was ‘moderate’ (0.66, 95% CI 0.33, 0.98). ESs were larger in non-obese participants (body mass index [BMI] < 30 vs. ≥ 30 kg/m2; 1.03 [95% CI 0.34, 1.73] vs. 0.53 [95% CI − 0.03, 1.09]). Among the studies included in this review, just one reported an acute injury, which did not result in the participant ceasing their involvement. JT was more effective in programmes with more than one exercise (range 1–4 exercises; ES = 0.74 [95% CI − 0.49, 1.96] vs. 0.53 [95% CI 0.29, 0.78]), more than two sets per exercise (range 1–4 sets; ES = 0.91 [95% CI 0.04, 1.77] vs. 0.68 [95% CI 0.15, 1.21]), more than three jumps per set (range 1–14 jumps; ES = 1.02 [95% CI 0.16, 1.87] vs. 0.53 [95% CI − 0.03, 1.09]) and more than 25 jumps per session (range 6–200 jumps; ES = 0.88 [95% CI 0.05, 1.70] vs. 0.49 [95% CI 0.14, 0.83]). Conclusions JT is safe and effective in older adults. Practitioners should construct varied JT programmes that include more than one exercise and comprise more than two sets per exercise, more than three jumps per set, and 60 s of recovery between sets. An upper limit of three sets per exercise and ten jumps per set is recommended. Up to three training sessions per week can be performed. Y1 - 2018 U6 - https://doi.org/10.1007/s40279-018-1002-5 SN - 0112-1642 SN - 1179-2035 VL - 48 IS - 12 SP - 2843 EP - 2857 PB - Springer CY - Northcote ER - TY - JOUR A1 - Yarman, Aysu A1 - Kurbanoglu, Sevinc A1 - Jetzschmann, Katharina J. A1 - Ozkan, Sibel A. A1 - Wollenberger, Ulla A1 - Scheller, Frieder W. T1 - Electrochemical MIP-Sensors for Drugs JF - Current Medicinal Chemistry N2 - In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV) and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR. Application of simple electrochemical devices allows both the reproducible preparation of MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer drugs have been presented in literature and tested under laboratory conditions. These biomimetic sensors typically have measuring ranges covering the lower nano-up to millimolar concentration range and they are stable under extreme pH and in organic solvents like nonaqueous extracts. KW - Biomimetic sensors KW - molecularly imprinted polymers KW - drug sensors KW - drug imprinting KW - electropolymerization KW - electrochemical sensors Y1 - 2018 U6 - https://doi.org/10.2174/0929867324666171005103712 SN - 0929-8673 SN - 1875-533X VL - 25 IS - 33 SP - 4007 EP - 4019 PB - Bentham Science Publishers LTD CY - Sharjah ER - TY - JOUR A1 - Laux, Eva-Maria A1 - Bier, Frank Fabian A1 - Hölzel, Ralph T1 - Electrode-based AC electrokinetics of proteins BT - a mini-review JF - Bioelectrochemistry : official journal of the Bioelectrochemical Society ; an international journal devoted to electrochemical aspects of biology and biological aspects of electrochemistry N2 - Employing electric phenomena for the spatial manipulation of bioparticles from whole cells down to dissolved molecules has become a useful tool in biotechnology and analytics. AC electrokinetic effects like dielectrophoresis and AC electroosmosis are increasingly used to concentrate, separate and immobilize DNA and proteins. With the advance of photolithographical micro- and nanofabrication methods, novel or improved bioanalytical applications benefit from concentrating analytes, signal enhancement and locally controlled immobilization by AC electrokinetic effects. In this review of AC electrokinetics of proteins, the respective studies are classified according to their different electrode geometries: individual electrode pairs, interdigitated electrodes, quadrupole electrodes, and 3D configurations of electrode arrays. Known advantages and disadvantages of each layout are discussed. KW - AC electrokinetics KW - Dielectrophoresis KW - Electrodes KW - Electroosmosis KW - Proteins Y1 - 2017 U6 - https://doi.org/10.1016/j.bioelechem.2017.11.010 SN - 1567-5394 SN - 1878-562X VL - 120 SP - 76 EP - 82 PB - Elsevier B.V. CY - Amsterdam ER - TY - JOUR A1 - Wyrwa, Ulrich T1 - Rezension zu: Enzyklopädie jüdischer Geschichte und Kultur, ed. Dan Diner, Sächsische Akademie der Wissenschaften zu Leipzig, (Stuttgart –Weimar: Metzler, 2011-2017), 7 Vol T1 - Encyclopedia of Jewish History and Culture JF - Quest-Issues in Contemporary Jewish History Y1 - 2018 U6 - https://doi.org/10.48248/issn.2037-741X/682 SN - 2037-741X VL - 2018 IS - 14 SP - 123 EP - 131 PB - Fondazione Centro Documentazione Ebraica Contemporanea CY - Milano ER - TY - JOUR A1 - Bálint, Miklós A1 - Pfenninger, Markus A1 - Grossart, Hans-Peter A1 - Taberlet, Pierre A1 - Vellend, Mark A1 - Leibold, Mathew A. A1 - Englund, Goran A1 - Bowler, Diana T1 - Environmental DNA time series in ecology JF - Trends in ecology & evolution N2 - Ecological communities change in time and space, but long-term dynamics at the century-to-millennia scale are poorly documented due to lack of relevant data sets. Nevertheless, understanding long-term dynamics is important for explaining present-day biodiversity patterns and placing conservation goals in a historical context. Here, we use recent examples and new perspectives to highlight how environmental DNA (eDNA) is starting to provide a powerful new source of temporal data for research questions that have so far been overlooked, by helping to resolve the ecological dynamics of populations, communities, and ecosystems over hundreds to thousands of years. We give examples of hypotheses that may be addressed by temporal eDNA biodiversity data, discuss possible research directions, and outline related challenges. Y1 - 2018 U6 - https://doi.org/10.1016/j.tree.2018.09.003 SN - 0169-5347 SN - 1872-8383 VL - 33 IS - 12 SP - 945 EP - 957 PB - Elsevier CY - London ER - TY - JOUR A1 - Lawrence, Mark A1 - Schäfer, Stefan A1 - Muri, Helene A1 - Scott, Vivian A1 - Oschlies, Andreas A1 - Vaughan, Naomi E. A1 - Boucher, Olivier A1 - Schmidt, Hauke A1 - Haywood, Jim A1 - Scheffran, Jürgen T1 - Evaluating climate geoengineering proposals in the context of the Paris Agreement temperature goals JF - Nature Communications N2 - Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide removal or farther-reaching interventions altering the Earth’s radiative energy budget. Although research indicates that several techniques may eventually have the physical potential to contribute to limiting climate change, all are in early stages of development, involve substantial uncertainties and risks, and raise ethical and governance dilemmas. Based on present knowledge, climate geoengineering techniques cannot be relied on to significantly contribute to meeting the Paris Agreement temperature goals. KW - Atmospheric chemistry KW - Atmospheric dynamics KW - Atmospheric science KW - Climate change KW - Environmental impact Y1 - 2018 U6 - https://doi.org/10.1038/s41467-018-05938-3 SN - 2041-1723 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Galbete, Cecilia A1 - Schwingshackl, Lukas A1 - Schwedhelm, Carolina A1 - Boeing, Heiner A1 - Schulze, Matthias Bernd T1 - Evaluating Mediterranean diet and risk of chronic disease in cohort studies BT - an umbrella review of meta-analyses JF - European journal of epidemiology N2 - Several meta-analyses have been published summarizing the associations of the Mediterranean diet (MedDiet) with chronic diseases. We evaluated the quality and credibility of evidence from these meta-analyses as well as characterized the different indices used to define MedDiet and re-calculated the associations with the different indices identified. We conducted an umbrella review of meta-analyses on cohort studies evaluating the association of the MedDiet with type 2 diabetes, cardiovascular disease, cancer and cognitive-related diseases. We used the AMSTAR (A MeaSurement Tool to Assess systematic Reviews) checklist to evaluate the methodological quality of the meta-analyses, and the NutriGrade scoring system to evaluate the credibility of evidence. We also identified different indices used to define MedDiet; tests for subgroup differences were performed to compare the associations with the different indices when at least 2 studies were available for different definitions. Fourteen publications were identified and within them 27 meta-analyses which were based on 70 primary studies. Almost all meta-analyses reported inverse associations between MedDiet and risk of chronic disease, but the credibility of evidence was rated low to moderate. Moreover, substantial heterogeneity was observed on the use of the indices assessing adherence to the MedDiet, but two indices were the most used ones [Trichopoulou MedDiet (tMedDiet) and alternative MedDiet (aMedDiet)]. Overall, we observed little difference in risk associations comparing different MedDiet indices in the subgroup meta-analyses. Future prospective cohort studies are advised to use more homogenous definitions of the MedDiet to improve the comparability across meta-analyses. KW - Mediterranean diet KW - Chronic diseases KW - Umbrella review KW - Meta-analyses KW - Cohort studies KW - Heterogeneity Y1 - 2018 U6 - https://doi.org/10.1007/s10654-018-0427-3 SN - 0393-2990 SN - 1573-7284 VL - 33 IS - 10 SP - 909 EP - 931 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Wozniak, Natalia Joanna A1 - Sicard, Adrien T1 - Evolvability of flower geometry BT - Convergence in pollinator-driven morphological evolution of flowers JF - Seminars in cell & developmental biology N2 - Flowers represent a key innovation during plant evolution. Driven by reproductive optimization, evolution of flower morphology has been central in boosting species diversification. In most cases, this has happened through specialized interactions with animal pollinators and subsequent reduction of gene flow between specialized morphs. While radiation has led to an enormous variability in flower forms and sizes, recurrent evolutionary patterns can be observed. Here, we discuss the targets of selection involved in major trends of pollinator-driven flower evolution. We review recent findings on their adaptive values, developmental grounds and genetic bases, in an attempt to better understand the repeated nature of pollinator-driven flower evolution. This analysis highlights how structural innovation can provide flexibility in phenotypic evolution, adaptation and speciation. (C) 2017 Elsevier Ltd. All rights reserved. KW - Flower KW - Developmental evolution KW - Morphogenesis KW - Angiosperms KW - Co-evolution KW - Plant-pollinator interactions Y1 - 2018 U6 - https://doi.org/10.1016/j.semcdb.2017.09.028 SN - 1084-9521 VL - 79 SP - 3 EP - 15 PB - Elsevier CY - London ER - TY - JOUR A1 - Hansen, Dominique A1 - Niebauer, Josef A1 - Cornelissen, Veronique A1 - Barna, Olga A1 - Neunhaeuserer, Daniel A1 - Stettler, Christoph A1 - Tonoli, Cajsa A1 - Greco, Eugenio A1 - Fagard, Robert A1 - Coninx, Karin A1 - Vanhees, Luc A1 - Piepoli, Massimo F. A1 - Pedretti, Roberto A1 - Ruiz, Gustavo Rovelo A1 - Corra, Ugo A1 - Schmid, Jean-Paul A1 - Davos, Constantinos H. A1 - Edelmann, Frank A1 - Abreu, Ana A1 - Rauch, Bernhard A1 - Ambrosetti, Marco A1 - Braga, Simona Sarzi A1 - Beckers, Paul A1 - Bussotti, Maurizio A1 - Faggiano, Pompilio A1 - Garcia-Porrero, Esteban A1 - Kouidi, Evangelia A1 - Lamotte, Michel A1 - Reibis, Rona Katharina A1 - Spruit, Martijn A. A1 - Takken, Tim A1 - Vigorito, Carlo A1 - Völler, Heinz A1 - Doherty, Patrick A1 - Dendale, Paul T1 - Exercise prescription in patients with different combinations of cardiovascular disease risk factors BT - a consensus statement from the EXPERT working group JF - Sports medicine N2 - Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in patients with combinations of CVD risk factors as integrated into a digital training and decision support system (the EXercise Prescription in Everyday practice & Rehabilitative Training (EXPERT) tool) needed to be established. EXPERT working group members systematically reviewed the literature for meta-analyses, systematic reviews and/or clinical studies addressing exercise prescriptions in specific CVD risk factors and formulated exercise recommendations (exercise training intensity, frequency, volume and type, session and programme duration) and exercise safety precautions, for obesity, arterial hypertension, type 1 and 2 diabetes, and dyslipidaemia. The impact of physical fitness, CVD risk altering medications and adverse events during exercise testing was further taken into account to fine-tune this exercise prescription. An algorithm, supported by the interactive EXPERT tool, was developed by Hasselt University based on these data. Specific exercise recommendations were formulated with the aim to decrease adipose tissue mass, improve glycaemic control and blood lipid profile, and lower blood pressure. The impact of medications to improve CVD risk, adverse events during exercise testing and physical fitness was also taken into account. Simulations were made of how the EXPERT tool provides exercise prescriptions according to the variables provided. In this paper, state-of-the-art exercise prescription to patients with combinations of CVD risk factors is formulated, and it is shown how the EXPERT tool may assist clinicians. This contributes to an appropriately tailored exercise regimen for every CVD risk patient. Y1 - 2018 U6 - https://doi.org/10.1007/s40279-018-0930-4 SN - 0112-1642 SN - 1179-2035 VL - 48 IS - 8 SP - 1781 EP - 1797 PB - Springer CY - Northcote ER - TY - JOUR A1 - Puppe, Daniel A1 - Sommer, Michael T1 - Experiments, uptake mechanisms, and functioning of silicon foliar fertilization BT - a review focusing on Maize, Rice, and Wheat JF - Advances in Agronomy ; 152 N2 - Silicon (Si) is considered as a quasiessential element for higher plants as its uptake increases plant growth and resistance against abiotic as well as biotic stresses. Foliar application of fertilizers generally is assumed to be a comparably environment-friendly form of fertilization because only small quantities are needed. The interest in foliar fertilization and the use of Si as a fertilizer in general increased significantly within the last decades, but there are only few publications dealing with the foliar application of Si at all. In the present review, the effects of Si foliar fertilization, including nano-Si fertilizers, on the three most important crops on a global scale, that is, maize, rice, and wheat, are summarized. Additionally, different pathways (i.e., cuticular pathways, stomata, and trichomes) of foliar uptake and functioning of Si foliar fertilizers against biotic (i.e., fungal diseases and harmful insects), as well as abiotic (i.e., water stress, macronutrient imbalance, and heavy metal toxicity) stressors are discussed. Future research should especially focus on (1) the gathering of empirical data from field and greenhouse experiments, (2) the intensification of co-operations between practitioners and scientists, (3) interdisciplinary research, and (4) the analysis of results from multiple studies (meta-analysis, big data) to fully understand effects, uptake, and functioning of Si foliar fertilizers and to evaluate their potential in modern sustainable agriculture concepts. Y1 - 2018 SN - 978-0-12-815171-6 U6 - https://doi.org/10.1016/bs.agron.2018.07.003 SN - 0065-2113 VL - 152 SP - 1 EP - 49 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Laitinen, Roosa A. E. A1 - Nikoloski, Zoran T1 - Genetic basis of plasticity in plants JF - Journal of experimental botany N2 - The ability of an organism to change its phenotype in response to different environments, termed plasticity, is a particularly important characteristic to enable sessile plants to adapt to rapid changes in their surroundings. Plasticity is a quantitative trait that can provide a fitness advantage and mitigate negative effects due to environmental perturbations. Yet, its genetic basis is not fully understood. Alongside technological limitations, the main challenge in studying plasticity has been the selection of suitable approaches for quantification of phenotypic plasticity. Here, we propose a categorization of the existing quantitative measures of phenotypic plasticity into nominal and relative approaches. Moreover, we highlight the recent advances in the understanding of the genetic architecture underlying phenotypic plasticity in plants. We identify four pillars for future research to uncover the genetic basis of phenotypic plasticity, with emphasis on development of computational approaches and theories. These developments will allow us to perform specific experiments to validate the causal genes for plasticity and to discover their role in plant fitness and evolution. KW - Genetic architecture KW - GWA KW - GxE interaction KW - hub genes KW - plant adaptation KW - plasticity KW - variance Y1 - 2018 U6 - https://doi.org/10.1093/jxb/ery404 SN - 0022-0957 SN - 1460-2431 VL - 70 IS - 3 SP - 739 EP - 745 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Romero-Mujalli, Daniel A1 - Jeltsch, Florian A1 - Tiedemann, Ralph T1 - Individual-based modeling of eco-evolutionary dynamics BT - state of the art and future directions JF - Regional environmental change N2 - A challenge for eco-evolutionary research is to better understand the effect of climate and landscape changes on species and their distribution. Populations of species can respond to changes in their environment through local genetic adaptation or plasticity, dispersal, or local extinction. The individual-based modeling (IBM) approach has been repeatedly applied to assess organismic responses to environmental changes. IBMs simulate emerging adaptive behaviors from the basic entities upon which both ecological and evolutionary mechanisms act. The objective of this review is to summarize the state of the art of eco-evolutionary IBMs and to explore to what degree they already address the key responses of organisms to environmental change. In this, we identify promising approaches and potential knowledge gaps in the implementation of eco-evolutionary mechanisms to motivate future research. Using mainly the ISI Web of Science, we reveal that most of the progress in eco-evolutionary IBMs in the last decades was achieved for genetic adaptation to novel local environmental conditions. There is, however, not a single eco-evolutionary IBM addressing the three potential adaptive responses simultaneously. Additionally, IBMs implementing adaptive phenotypic plasticity are rare. Most commonly, plasticity was implemented as random noise or reaction norms. Our review further identifies a current lack of models where plasticity is an evolving trait. Future eco-evolutionary models should consider dispersal and plasticity as evolving traits with their associated costs and benefits. Such an integrated approach could help to identify conditions promoting population persistence depending on the life history strategy of organisms and the environment they experience. KW - Modeling KW - Individual-based models KW - Ecology KW - Evolution KW - Eco-evolutionary dynamics Y1 - 2018 U6 - https://doi.org/10.1007/s10113-018-1406-7 SN - 1436-3798 SN - 1436-378X VL - 19 IS - 1 SP - 1 EP - 12 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Kluge, Annette A1 - Gronau, Norbert T1 - Intentional forgetting in organizations BT - the Importance of Eliminating Retrieval Cues for Implementing New Routines JF - Frontiers in psychology N2 - To cope with the already large, and ever increasing, amount of information stored in organizational memory, "forgetting," as an important human memory process, might be transferred to the organizational context. Especially in intentionally planned change processes (e.g., change management), forgetting is an important precondition to impede the recall of obsolete routines and adapt to new strategic objectives accompanied by new organizational routines. We first comprehensively review the literature on the need for organizational forgetting and particularly on accidental vs. intentional forgetting. We discuss the current state of the art of theory and empirical evidence on forgetting from cognitive psychology in order to infer mechanisms applicable to the organizational context. In this respect, we emphasize retrieval theories and the relevance of retrieval cues important for forgetting. Subsequently, we transfer the empirical evidence that the elimination of retrieval cues leads to faster forgetting to the forgetting of organizational routines, as routines are part of organizational memory. We then propose a classification of cues (context, sensory, business process-related cues) that are relevant in the forgetting of routines, and discuss a meta-cue called the "situational strength" cue, which is relevant if cues of an old and a new routine are present simultaneously. Based on the classification as business process-related cues (information, team, task, object cues), we propose mechanisms to accelerate forgetting by eliminating specific cues based on the empirical and theoretical state of the art. We conclude that in intentional organizational change processes, the elimination of cues to accelerate forgetting should be used in change management practices. KW - change management KW - multi-actor routines KW - business processes KW - knowledge management KW - organizational memory KW - situational strength Y1 - 2018 U6 - https://doi.org/10.3389/fpsyg.2018.00051 SN - 1664-1078 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Turner, Bryan S. T1 - Islam, gender, and democracy in comparative perspective JF - Journal of Religious and Political Practice Y1 - 2018 U6 - https://doi.org/10.1080/20566093.2018.1439439 SN - 2056-6093 SN - 2056-6107 VL - 4 IS - 2 SP - 195 EP - 201 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Ariel, Yaakov S. T1 - Ismar Schorsch: Leopold Zunz. Creativity in Adversity / [rezensiert von] Yaakov Ariel JF - PaRDES : Zeitschrift der Vereinigung für Jüdische Studien e. V. Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-417918 SP - 239 EP - 241 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Homolka, Walter T1 - Jewish theology and Jewish studies in Germany BT - Reflections in relation to the development of the research field in Norway JF - Nordisk judaistik/Scandinavian Jewish Studies N2 - This article presents some insights into the German developments of studying Judaism and the Jewish tradition and relates them to the ongoing development of the subject at universities in the Nordic countries in general and Norway in particular. It also aims to present some conclusions concerning why it might be interesting for Norwegian society to intensify the study of Judaism at its universities. KW - Jewish studies KW - Jews in Norway KW - Jewish Studies in Germany Y1 - 2018 U6 - https://doi.org/10.30752/nj.70966 SN - 0348-1646 SN - 2343-4929 VL - 29 IS - 2 SP - 26 EP - 35 PB - Donner Institute CY - Åbo ER - TY - JOUR A1 - Machatschek, Rainhard Gabriel A1 - Schulz, Burkhard A1 - Lendlein, Andreas T1 - Langmuir Monolayers as Tools to Study Biodegradable Polymer Implant Materials JF - Macromolecular rapid communications N2 - Langmuir monolayers provide a fast and elegant route to analyze the degradation behavior of biodegradable polymer materials. In contrast to bulk materials, diffusive transport of reactants and reaction products in the (partially degraded) material can be neglected at the air-water interface, allowing for the study of molecular degradation kinetics in experiments taking less than a day and in some cases just a few minutes, in contrast to experiments with bulk materials that can take years. Several aspects of the biodegradation behavior of polymer materials, such as the interaction with biomolecules and degradation products, are directly observable. Expanding the technique with surface-sensitive instrumental techniques enables evaluating the evolution of the morphology, chemical composition, and the mechanical properties of the degrading material in situ. The potential of the Langmuir monolayer degradation technique as a predictive tool for implant degradation when combined with computational methods is outlined, and related open questions and strategies to overcome these challenges are pointed out. KW - biomaterial characterization KW - langmuir monolayers KW - polymer degradation KW - predictive characterization tools Y1 - 2018 U6 - https://doi.org/10.1002/marc.201800611 SN - 1022-1336 SN - 1521-3927 VL - 40 IS - 1 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - van Helden, Jan A1 - Reichard, Christoph T1 - Management control and public sector performance management JF - Baltic Journal of Management N2 - Purpose The purpose of this paper is to investigate whether and how evolving ideas about management control (MC) emerge in research about public sector performance management (PSPM). Design/methodology/approach This is a literature review on PSPM research through using a set of key terms derived from a review of recent developments in MC. Findings MC research, originating in the management accounting discipline, is largely disconnected from PSPM research as part of public administration and public management disciplines. Overlaps between MC and PSPM research are visible in a cybernetic control approach, control variety and contingency-based reasoning. Both academic communities share an understanding of certain issues, although under diverging labels, especially enabling controls or, in a more general sense, usable performance controls, horizontal controls and control packaging. Specific MC concepts are valuable for future PSPM research, i.e. trust as a complement of performance-based controls in complex settings, and strategy as a variable in contingency-based studies. Research limitations/implications Breaking the boundaries between two currently remote research disciplines, on the one hand, might dismantle “would-be” innovations in one of these disciplines, and, on the other hand, may provide a fertile soil for mutual transfer of knowledge. A limitation of the authors’ review of PSPM research is that it may insufficiently cover research published in the public sector accounting journals, which could be an outlet for MC-inspired PSPM research. Originality/value The paper unravels the “apparent” and “real” differences between MC and PSPM research, and, in doing so, takes the detected “real” differences as a starting point for discussing in what ways PSPM research can benefit from MC achievements. KW - Public sector KW - Performance management KW - Management control Y1 - 2018 U6 - https://doi.org/10.1108/BJM-01-2018-0021 SN - 1746-5265 SN - 1746-5273 VL - 14 IS - 1 SP - 158 EP - 176 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Fritz, Michael Andre A1 - Rosa, Stefanie A1 - Sicard, Adrien T1 - Mechanisms Underlying the Environmentally Induced Plasticity of Leaf Morphology JF - Frontiers in genetics N2 - The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth. Their final geometry will result from a balance between the need to maximize energy uptake while minimizing the damage caused by environmental stresses. This intimate relationship between leaf and its surroundings has led to an enormous diversification in leaf forms. Leaf shape varies between species, populations, individuals or even within identical genotypes when those are subjected to different environmental conditions. For instance, the extent of leaf margin dissection has, for long, been found to inversely correlate with the mean annual temperature, such that Paleobotanists have used models based on leaf shape to predict the paleoclimate from fossil flora. Leaf growth is not only dependent on temperature but is also regulated by many other environmental factors such as light quality and intensity or ambient humidity. This raises the question of how the different signals can be integrated at the molecular level and converted into clear developmental decisions. Several recent studies have started to shed the light on the molecular mechanisms that connect the environmental sensing with organ-growth and patterning. In this review, we discuss the current knowledge on the influence of different environmental signals on leaf size and shape, their integration as well as their importance for plant adaptation. KW - plants KW - leaf morphology KW - environment KW - developmental plasticity KW - gene regulatory networks KW - sensory system KW - gene responsiveness Y1 - 2018 U6 - https://doi.org/10.3389/fgene.2018.00478 SN - 1664-8021 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Schulze, Matthias Bernd T1 - Metabolic health in normal-weight and obese individuals JF - Diabetologia : journal of the European Association for the Study of Diabetes (EASD) N2 - Cardiovascular complications are commonly associated with obesity. However, a subgroup of obese individuals may not be at an increased risk for cardiovascular complications; these individuals are said to have metabolically healthy obesity (MHO). In contrast, metabolically unhealthy individuals are at high risk of cardiovascular disease (CVD), irrespective of BMI; thus, this group can include individuals within the normal weight category (BMI 18.5-24.9kg/m(2)). This review provides a summary of prospective studies on MHO and metabolically unhealthy normal-weight (MUHNW) phenotypes. Notably, there is ongoing dispute surrounding the concept of MHO, including the lack of a uniform definition and the potentially transient nature of metabolic health status. This review highlights the relevance of alternative measures of body fatness, specifically measures of fat distribution, for determining MHO and MUHNW. It also highlights alternative approaches of risk stratification, which account for the continuum of risk in relation to CVD, which is observable for most risk factors. Moreover, studies evaluating the transition from metabolically healthy to unhealthy phenotypes and potential determinants for such conversions are discussed. Finally, the review proposes several strategies for the use of epidemiological research to further inform the current debate on metabolic health and its determination across different stages of body fatness. KW - Cardiovascular diseases KW - Cohort studies KW - Metabolically benign KW - Obesity KW - Review Y1 - 0208 U6 - https://doi.org/10.1007/s00125-018-4787-8 SN - 0012-186X SN - 1432-0428 VL - 62 IS - 4 SP - 558 EP - 566 PB - Springer CY - New York ER - TY - JOUR A1 - Ramirez-Campillo, Rodrigo A1 - Alvarez, Cristian A1 - Garcia-Hermoso, Antonio A1 - Ramirez-Velez, Robinson A1 - Gentil, Paulo A1 - Asadi, Abbas A1 - Chaabene, Helmi A1 - Moran, Jason A1 - Meylan, Cesar A1 - Garcia-de-Alcaraz, Antonio A1 - Sanchez-Sanchez, Javier A1 - Nakamura, Fabio Y. A1 - Granacher, Urs A1 - Kraemer, William A1 - Izquierdo, Mikel T1 - Methodological characteristics and future directions for plyometric jump training research BT - a scoping review JF - Sports medicine N2 - Recently, there has been a proliferation of published articles on the effect of plyometric jump training, including several review articles and meta-analyses. However, these types of research articles are generally of narrow scope. Furthermore, methodological limitations among studies (e.g., a lack of active/passive control groups) prevent the generalization of results, and these factors need to be addressed by researchers. On that basis, the aims of this scoping review were to (1) characterize the main elements of plyometric jump training studies (e.g., training protocols) and (2) provide future directions for research. From 648 potentially relevant articles, 242 were eligible for inclusion in this review. The main issues identified related to an insufficient number of studies conducted in females, youths, and individual sports (~ 24.0, ~ 37.0, and ~ 12.0% of overall studies, respectively); insufficient reporting of effect size values and training prescription (~ 34.0 and ~ 55.0% of overall studies, respectively); and studies missing an active/passive control group and randomization (~ 40.0 and ~ 20.0% of overall studies, respectively). Furthermore, plyometric jump training was often combined with other training methods and added to participants’ daily training routines (~ 47.0 and ~ 39.0% of overall studies, respectively), thus distorting conclusions on its independent effects. Additionally, most studies lasted no longer than 7 weeks. In future, researchers are advised to conduct plyometric training studies of high methodological quality (e.g., randomized controlled trials). More research is needed in females, youth, and individual sports. Finally, the identification of specific dose-response relationships following plyometric training is needed to specifically tailor intervention programs, particularly in the long term. Y1 - 2018 U6 - https://doi.org/10.1007/s40279-018-0870-z SN - 0112-1642 SN - 1179-2035 VL - 48 IS - 5 SP - 1059 EP - 1081 PB - Springer CY - Northcote ER - TY - JOUR A1 - Mühlenbruch, Marco A1 - Grossart, Hans-Peter A1 - Eigemann, Falk A1 - Voss, Maren T1 - Mini-review: Phytoplankton-derived polysaccharides in the marine environment and their interactions with heterotrophic bacteria JF - Environmental microbiology N2 - Within the wealth of molecules constituting marine dissolved organic matter, carbohydrates make up the largest coherent and quantifiable fraction. Their main sources are from primary producers, which release large amounts of photosynthetic products – mainly polysaccharides – directly into the surrounding water via passive and active exudation. The organic carbon and other nutrients derived from these photosynthates enrich the ‘phycosphere’ and attract heterotrophic bacteria. The rapid uptake and remineralization of dissolved free monosaccharides by heterotrophic bacteria account for the barely detectable levels of these compounds. By contrast, dissolved combined polysaccharides can reach high concentrations, especially during phytoplankton blooms. Polysaccharides are too large to be taken up directly by heterotrophic bacteria, instead requiring hydrolytic cleavage to smaller oligo- or monomers by bacteria with a suitable set of exoenzymes. The release of diverse polysaccharides by various phytoplankton taxa is generally interpreted as the deposition of excess organic material. However, these molecules likely also fulfil distinct, yet not fully understood functions, as inferred from their active modulation in terms of quality and quantity when phytoplankton becomes nutrient limited or is exposed to heterotrophic bacteria. This minireview summarizes current knowledge regarding the exudation and composition of phytoplankton-derived exopolysaccharides and acquisition of these compounds by heterotrophic bacteria. Y1 - 2018 U6 - https://doi.org/10.1111/1462-2920.14302 SN - 1462-2912 SN - 1462-2920 VL - 20 IS - 8 SP - 2671 EP - 2685 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Quiterio, Ana A1 - Martins, Joao A1 - Onofre, Marcos A1 - Costa, Joao A1 - Rodrigues, Joao Mota A1 - Gerlach, Erin A1 - Scheur, Claude A1 - Herrmann, Christian T1 - MOBAK 1 assessment in primary physical education BT - exploring basic motor competences of portuguese 6-Year-Olds JF - Perceptual & motor skills N2 - Children’s motor competence is known to have a determinant role in learning and engaging later in complex motor skills and, thus, in physical activity. The development of adequate motor competence is a central aim of physical education, and assuring that pupils are learning and developing motor competence depends on accurate assessment protocols. The MOBAK 1 test battery is a recent instrument developed to assess motor competence in primary physical education. This study used the MOBAK 1 to explore motor competence levels and gender differences among 249 (Mage = 6.3, SD = 0.5 years; 127 girls and 122 boys) Grade 1 primary school Portuguese children. On independent sample t tests, boys presented higher object movement motor competence than girls (boys: M = 5.8, SD = 1.7; girls: M = 4.0, SD = 1.7; p < .001), while girls were more proficient among self-movement skills (girls: M = 5.1, SD = 1.8; boys: M = 4.3, SD = 1.7; p < .01). On “total motor competence,” boys (M = 10.3, SD = 2.6) averaged one point ahead of girls (M = 9.1, SD = 2.9). The percentage of girls in the first quartile of object movement was 18.9%, while, for “self movement,” the percentage of boys in the first quartile was almost double that of girls (30.3% and 17.3%, respectively). The confirmatory model to test for construct validity confirmed the assumed theoretical two-factor structure of MOBAK 1 test items in this Portuguese sample. These results support the MOBAK 1 instrument for assessing motor competence and highlighted gender differences, of relevance to intervention efforts. KW - physical education KW - MOBAK 1 KW - instrument KW - assessment KW - motor competence Y1 - 2018 U6 - https://doi.org/10.1177/0031512518804358 SN - 0031-5125 SN - 1558-688X VL - 125 IS - 6 SP - 1055 EP - 1069 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Bridwell, David A. A1 - Cavanagh, James F. A1 - Collins, Anne G. E. A1 - Nunez, Michael D. A1 - Srinivasan, Ramesh A1 - Stober, Sebastian A1 - Calhoun, Vince D. T1 - Moving Beyond ERP Components BT - a selective review of approaches to integrate EEG and behavior JF - Frontiers in human neuroscienc N2 - Relationships between neuroimaging measures and behavior provide important clues about brain function and cognition in healthy and clinical populations. While electroencephalography (EEG) provides a portable, low cost measure of brain dynamics, it has been somewhat underrepresented in the emerging field of model-based inference. We seek to address this gap in this article by highlighting the utility of linking EEG and behavior, with an emphasis on approaches for EEG analysis that move beyond focusing on peaks or "components" derived from averaging EEG responses across trials and subjects (generating the event-related potential, ERP). First, we review methods for deriving features from EEG in order to enhance the signal within single-trials. These methods include filtering based on user-defined features (i.e., frequency decomposition, time-frequency decomposition), filtering based on data-driven properties (i.e., blind source separation, BSS), and generating more abstract representations of data (e.g., using deep learning). We then review cognitive models which extract latent variables from experimental tasks, including the drift diffusion model (DDM) and reinforcement learning (RL) approaches. Next, we discuss ways to access associations among these measures, including statistical models, data-driven joint models and cognitive joint modeling using hierarchical Bayesian models (HBMs). We think that these methodological tools are likely to contribute to theoretical advancements, and will help inform our understandings of brain dynamics that contribute to moment-to-moment cognitive function. KW - EEG KW - ERP KW - blind source separation KW - partial least squares KW - canonical correlations analysis KW - representational similarity analysis KW - deep learning KW - hierarchical Bayesian model Y1 - 2018 U6 - https://doi.org/10.3389/fnhum.2018.00106 SN - 1662-5161 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - MacGrogan, Donal A1 - Münch, Juliane A1 - de la Pompa, José Luis T1 - Notch and interacting signalling pathways in cardiac development, disease, and regeneration JF - Nature Reviews Cardiology N2 - Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue-tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury. KW - Cardiac regeneration KW - Cell signalling KW - Congenital heart defects KW - Heart development Y1 - 2018 U6 - https://doi.org/10.1038/s41569-018-0100-2 SN - 1759-5002 SN - 1759-5010 VL - 15 IS - 11 SP - 685 EP - 704 PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Fischer, Martin H. A1 - Shaki, Samuel T1 - Number concepts: abstract and embodied JF - Philosophical transactions of the Royal Society of London : B, Biological sciences N2 - Numerical knowledge, including number concepts and arithmetic procedures, seems to be a clear-cut case for abstract symbol manipulation. Yet, evidence from perceptual and motor behaviour reveals that natural number knowledge and simple arithmetic also remain closely associated with modal experiences. Following a review of behavioural, animal and neuroscience studies of number processing, we propose a revised understanding of psychological number concepts as grounded in physical constraints, embodied in experience and situated through task-specific intentions. The idea that number concepts occupy a range of positions on the continuum between abstract and modal conceptual knowledge also accounts for systematic heuristics and biases in mental arithmetic, thus inviting psycho-logical approaches to the study of the mathematical mind. KW - embodied cognition KW - mental arithmetic KW - mental number line KW - numerical cognition KW - SNARC effect Y1 - 2018 U6 - https://doi.org/10.1098/rstb.2017.0125 SN - 0962-8436 SN - 1471-2970 VL - 373 IS - 1752 PB - Royal Society CY - London ER - TY - JOUR A1 - Gropalis, Maria A1 - Bailer, Josef A1 - Weck, Florian A1 - Witthöft, Michael T1 - Optimierung von Expositionstherapie bei pathologischen Krankheitsängsten T1 - Optimization of exposure therapy for pathological health anxiety BT - Theoretische Grundlagen und praktische Implikationen BT - Theoretical principles and practical implications JF - Psychotherapeut N2 - Pathologische Krankheitsängste wurden bislang nach ICD und DSM primär als somatoforme Störung bzw. als somatische Belastungsstörung klassifiziert. Theoretische Erwägungen und empirische Befunde legen jedoch nahe, dass es sich bei pathologischen Krankheitsängsten eigentlich um eine Angststörung handelt. Innerhalb des vorliegenden Beitrags wird dafür argumentiert, dass Defizite in der aktuellen Behandlungspraxis und in der Wahrnehmung von Patienten mit Hypochondrie als „schwierige Patienten“ teilweise auf Unklarheit in der Nosologie sowie bezüglich der entscheidenden Mechanismen der Entstehung und Aufrechterhaltung zurückzuführen sind. Ausgehend von innovativen theoretischen Ansätzen zur Erklärung pathologischer Krankheitsängste werden Vorschläge für eine verbesserte therapeutische Praxis skizziert. Der Fokus liegt hierbei auf einem verstärken Einsatz expositionsbasierter Behandlungselemente, die sich am „Inhibitory-learning“-Ansatz orientieren und sich bei anderen Angststörungen bereits bewährt haben. N2 - Up to now pathological health anxiety has been classified primarily as a somatoform disorder or a somatic symptom disorder in ICD and DSM. Theoretical and empirical evidence, however, suggest that pathological health anxiety basically represents an anxiety disorder. In this paper, it is argued that deficits in the treatment and perception of patients with pathological health anxiety as "difficult patients" are partly attributable to a lack of clarity in terms of nosology and with respect to central mechanisms of etiology and pathogenesis. Based on novel theoretical approaches for the explanation of pathological health anxiety, suggestions for an improved therapeutic practice are outlined. This approach focuses on a more intensive use of exposure-based treatment elements that are oriented to the inhibitory learning approach, which has already proven its effectiveness for other anxiety disorders. KW - Hypochondriasis KW - Anxiety disorders KW - Inhibition KW - Learning KW - Cognitive behavior therapy KW - Hypochondrie KW - Angststörungen KW - Inhibition KW - Lernen KW - Kognitive Verhaltenstherapie Y1 - 2018 U6 - https://doi.org/10.1007/s00278-018-0285-1 SN - 0935-6185 SN - 1432-2080 VL - 63 IS - 3 SP - 188 EP - 193 PB - Springer CY - New York ER - TY - JOUR A1 - Nakamura, Moritaka A1 - Grebe, Markus T1 - Outer, inner and planar polarity in the Arabidopsis root JF - Current opinion in plant biology N2 - Plant roots control uptake of water and nutrients and cope with environmental challenges. The root epidermis provides the first selective interface for nutrient absorption, while the endodermis produces the main apoplastic diffusion barrier in the form of a structure called the Casparian strip. The positioning of root hairs on epidermal cells, and of the Casparian strip around endodermal cells, requires asymmetries along cellular axes (cell polarity). Cell polarity is termed planar polarity, when coordinated within the plane of a given tissue layer. Here, we review recent molecular advances towards understanding both the polar positioning of the proteo-lipid membrane domain instructing root hair initiation, and the cytoskeletal, trafficking and polar tethering requirements of proteins at outer or inner plasma membrane domains. Finally, we highlight progress towards understanding mechanisms of Casparian strip formation and underlying endodermal cell polarity. Y1 - 2017 U6 - https://doi.org/10.1016/j.pbi.2017.08.002 SN - 1369-5266 SN - 1879-0356 VL - 41 SP - 46 EP - 53 PB - Elsevier CY - London ER - TY - JOUR A1 - Krstic, Jelena A1 - Galhuber, Markus A1 - Schulz, Tim Julius A1 - Schupp, Michael A1 - Prokesch, Andreas T1 - p53 as a dichotomous regulator of liver disease BT - the dose makes the medicine JF - International journal of molecular sciences N2 - Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While the prevalence of liver pathologies is steadily increasing in modern societies, there are currently no approved drugs other than chemotherapeutic intervention in late stage HCC. Hence, there is a pressing need to identify and investigate causative molecular pathways that can yield new therapeutic avenues. The transcription factor p53 is well established as a tumor suppressor and has recently been described as a central metabolic player both in physiological and pathological settings. Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an important regulator of liver homeostasis and dysfunction. The underlying evidence is reviewed herein, with a focus on clinical data and animal studies that highlight a direct influence of p53 activity on different stages of liver diseases. Based on current literature showing that activation of p53 signaling can either attenuate or fuel liver disease, we herein discuss the hypothesis that, while hyper-activation or loss of function can cause disease, moderate induction of hepatic p53 within physiological margins could be beneficial in the prevention and treatment of liver pathologies. Hence, stimuli that lead to a moderate and temporary p53 activation could present new therapeutic approaches through several entry points in the cascade from hepatic steatosis to HCC. KW - p53 KW - liver disease KW - insulin resistance KW - non-alcoholic fatty liver disease KW - non-alcoholic steatohepatitis KW - hepatocellular carcinoma KW - liver regeneration KW - mouse models Y1 - 2018 U6 - https://doi.org/10.3390/ijms19030921 SN - 1422-0067 VL - 19 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Krstic, Jelena A1 - Reinisch, Isabel A1 - Schupp, Michael A1 - Schulz, Tim Julius A1 - Prokesch, Andreas T1 - p53 functions in adipose tissue metabolism and homeostasis JF - International journal of molecular sciences N2 - As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the best-described molecules in medical research. As cancer is in most cases an age-related disease, it seems paradoxical that p53 is so strongly conserved from early multicellular organisms to humans. A function not directly related to tumor suppression, such as the regulation of metabolism in nontransformed cells, could explain this selective pressure. While this role of p53 in cellular metabolism is gradually emerging, it is imperative to dissect the tissue-and cell-specific actions of p53 and its downstream signaling pathways. In this review, we focus on studies reporting p53's impact on adipocyte development, function, and maintenance, as well as the causes and consequences of altered p53 levels in white and brown adipose tissue (AT) with respect to systemic energy homeostasis. While whole body p53 knockout mice gain less weight and fat mass under a high-fat diet owing to increased energy expenditure, modifying p53 expression specifically in adipocytes yields more refined insights: (1) p53 is a negative regulator of in vitro adipogenesis; (2) p53 levels in white AT are increased in diet-induced and genetic obesity mouse models and in obese humans; (3) functionally, elevated p53 in white AT increases senescence and chronic inflammation, aggravating systemic insulin resistance; (4) p53 is not required for normal development of brown AT; and (5) when p53 is activated in brown AT in mice fed a high-fat diet, it increases brown AT temperature and brown AT marker gene expression, thereby contributing to reduced fat mass accumulation. In addition, p53 is increasingly being recognized as crucial player in nutrient sensing pathways. Hence, despite existence of contradictory findings and a varying density of evidence, several functions of p53 in adipocytes and ATs have been emerging, positioning p53 as an essential regulatory hub in ATs. Future studies need to make use of more sophisticated in vivo model systems and should identify an AT-specific set of p53 target genes and downstream pathways upon different (nutrient) challenges to identify novel therapeutic targets to curb metabolic diseases KW - p53 KW - adipose tissue KW - metabolic syndrome KW - obesity KW - adipogenesis KW - insulin resistance Y1 - 2018 U6 - https://doi.org/10.3390/ijms19092622 SN - 1422-0067 VL - 19 IS - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Cisek, Richard A1 - Tokarz, Danielle A1 - Kontenis, Lukas A1 - Barzda, Virginijus A1 - Steup, Martin T1 - Polarimetric second harmonic generation microscopy BT - an analytical tool for starch bioengineering JF - Starch-Starke N2 - Second harmonic generation (SHG) is a nonlinear optical process that inherently generates signal in non-centrosymmetric materials, such as starch granules, and therefore can be used for label-free imaging. Both intensity and polarization of SHG are determined by material properties that are characterized by the nonlinear susceptibility tensor, ((2)). Examination of the tensor is performed for each focal volume of the image by measuring the outgoing polarization state of the SHG signal for a set of incoming laser beam polarizations. Mapping of nonlinear properties expressed as the susceptibility ratio reveals structural features including the organization of crystalline material within a single starch granule, and the distribution of structural properties in a population of granules. Isolated granules, as well as in situ starch, can be analyzed using polarimetric SHG microscopy. Due to the fast sample preparation and short imaging times, polarimetric SHG microscopy allows for a quick assessment of starch structure and permits rapid feedback for bioengineering applications. This article presents the basics of SHG theory and microscopy applications for starch-containing materials. Quantification of ultrastructural features within individual starch granules is described. New results obtained by polarization resolved SHG microscopy of starch granules are presented for various maize genotypes revealing heterogeneity within a single starch particle and between various granules. KW - Determination of crystallinity KW - Determination of hydration KW - Label-free imaging KW - Nonlinear optical microscopy KW - Structural determination Y1 - 2017 U6 - https://doi.org/10.1002/star.201700031 SN - 0038-9056 SN - 1521-379X VL - 70 IS - 1-2 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Ma, Jianli A1 - Li, Qi A1 - Kühn, Michael A1 - Nakaten, Natalie Christine T1 - Power-to-gas based subsurface energy storage BT - a review JF - Renewable and Sustainable Energy Reviews N2 - The Renewable energy power generation capacity has been rapidly increasing in China recently. Meanwhile, the contradiction between power supply and demand is becoming increasingly more prominent due to the intermittence of renewable energies. On the other hand, on the mitigation of carbon dioxide (CO2) emissions in China needs immediate attention. Power-to-Gas (PtG), a chemical energy storage technology, can convert surplus electricity into combustible gases. Subsurface energy storage can meet the requirements of long term storage with its large capacity. This paper provides a discussion of the entire PtG energy storage technology process and the current research progress. Based on the comparative study of different geological storage schemes for synthetic methane, their respective research progress and limitations are noted. In addition, a full investigation of the distribution and implementation of global PtG and CO2 capture and storage (CCS) demonstration projects is performed. Subsequently, the opportunities and challenges of the development of this technology in China are discussed based on techno-economic and ecological effects analysis. While PtG is expected to be a revolutionary technology that will replace traditional power systems, the main issues of site selection, energy efficiency and the economy still need to be adequately addressed. Additionally, based on the comprehensive discussion of the results of the analysis, power-to-gas and subsurface energy storage implementation strategies, as well as outlook in China are presented. KW - Renewable energy KW - Power-to-Gas KW - Subsurface energy storage KW - Underground gas storage KW - Carbon dioxide KW - Methane Y1 - 2018 U6 - https://doi.org/10.1016/j.rser.2018.08.056 SN - 1364-0321 VL - 97 SP - 478 EP - 496 PB - Elsevier CY - Oxford ER -