TY - GEN A1 - Beckus, Siegfried A1 - Bellissard, Jean A1 - De Nittis, Giuseppe T1 - Corrigendum to: Spectral continuity for aperiodic quantum systems I. General theory. - [Journal of functional analysis. - 275 (2018), 11, S. 2917 – 2977] T2 - Journal of functional analysis N2 - A correct statement of Theorem 4 in [1] is provided. The change does not affect the main results. KW - Haar system Y1 - 2019 U6 - https://doi.org/10.1016/j.jfa.2019.06.001 SN - 0022-1236 SN - 1096-0783 VL - 277 IS - 9 SP - 3351 EP - 3353 PB - Elsevier CY - San Diego ER - TY - GEN A1 - Blanchard, Gilles A1 - Scott, Clayton T1 - Corrigendum to: Classification with asymmetric label noise BT - Consistency and maximal denoising T2 - Electronic journal of statistics N2 - We point out a flaw in Lemma 15 of [1]. We also indicate how the main results of that section are still valid using a modified argument. Y1 - 2018 U6 - https://doi.org/10.1214/18-EJS1422 SN - 1935-7524 VL - 12 IS - 1 SP - 1779 EP - 1781 PB - Institute of Mathematical Statistics CY - Cleveland ER - TY - GEN A1 - Butuzov, Valentin F. A1 - Nefedov, N. N. A1 - Recke, Lutz A1 - Omel'chenko, Oleh T1 - Partly dissipative system with multizonal initial and boundary layers T2 - Journal of Physics: Conference Series N2 - For a singularly perturbed parabolic - ODE system we construct the asymptotic expansion in the small parameter in the case, when the degenerate equation has a double root. Such systems, which are called partly dissipative reaction-diffusion systems, are used to model various natural processes, including the signal transmission along axons, solid combustion and the kinetics of some chemical reactions. It turns out that the algorithm of the construction of the boundary layer functions and the behavior of the solution in the boundary layers essentially differ from that ones in case of a simple root. The multizonal initial and boundary layers behaviour was stated. Y1 - 2019 U6 - https://doi.org/10.1088/1742-6596/1205/1/012009 SN - 1742-6588 SN - 1742-6596 VL - 1205 PB - IOP Publ. CY - Bristol ER - TY - GEN A1 - Böckmann, Christine A1 - Ritter, Christoph A1 - Cappelletti, David T1 - Mathematical tool for a closure study of aerosol microphysical property retrieval using lidar and photometer data T2 - IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium N2 - We present a project combining lidar, photometer and particle counter data with a regularization software tool for a closure study of aerosol microphysical property retrieval. In a first step only lidar data are used to retrieve the particle size distribution (PSD). Secondly, photometer data are added, which results in a good consistency of the retrieved PSDs. Finally, those retrieved PSDs may be compared with the measured PSD from a particle counter. The data here were taken in Ny Alesund, Svalbard, as an example. KW - Aerosol KW - Raman lidar KW - photometer KW - inversion KW - regularization KW - particle microphysics Y1 - 2018 SN - 978-1-5386-7150-4 U6 - https://doi.org/10.1109/IGARSS.2018.8518674 SN - 2153-6996 SP - 5575 EP - 5578 PB - IEEE CY - New York ER - TY - GEN A1 - Grisic, Ana-Marija A1 - Huisinga, Wilhelm A1 - Reinisch, W. A1 - Kloft, Charlotte T1 - P485 Dosing infliximab in Crohn's disease BT - is adjustment for body size justified? T2 - Journal of Crohn's and Colitis N2 - Background: Infliximab (IFX), an anti-TNF monoclonal antibody approved for the treatment of inflammatory bowel disease, is dosed per kg body weight (BW). However, the rationale for body size adjustment has not been unequivocally demonstrated [1], and first attempts to improve IFX therapy have been undertaken [2]. The aim of our study was to assess the impact of different dosing strategies (i.e. body size-adjusted and fixed dosing) on drug exposure and pharmacokinetic (PK) target attainment. For this purpose, a comprehensive simulation study was performed, using patient characteristics (n=116) from an in-house clinical database. Methods: IFX concentration-time profiles of 1000 virtual, clinically representative patients were generated using a previously published PK model for IFX in patients with Crohn's disease [3]. For each patient 1000 profiles accounting for PK variability were considered. The IFX exposure during maintenance treatment after the following dosing strategies was compared: i) fixed dose, and per ii) BW, iii) lean BW (LBW), iv) body surface area (BSA), v) height (HT), vi) body mass index (BMI) and vii) fat-free mass (FFM)). For each dosing strategy the variability in maximum concentration Cmax, minimum concentration Cmin (= C8weeks) and area under the concentration-time curve (AUC), as well as percent of patients achieving the PK target, Cmin=3 μg/mL [4] were assessed. Results: For all dosing strategies the variability of Cmin (CV ≈110%) was highest, compared to Cmax and AUC, and was of similar extent regardless of dosing strategy. The proportion of patients reaching the PK target (≈⅓ was approximately equal for all dosing strategies. Y1 - 2017 U6 - https://doi.org/10.1093/ecco-jcc/jjx002.609 SN - 1873-9946 SN - 1876-4479 VL - 11 IS - 1 SP - S325 EP - S326 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Klotzek, Benno T1 - Makarov, V. S., On the fundamental polyhedron of a diskrete group of motions of a Lobachevskii space, its combinatorics and deformation Y1 - 1995 ER - TY - GEN A1 - Klotzek, Benno T1 - Falkner, N., A characterization of inner product spaces Y1 - 1994 ER - TY - GEN A1 - Klotzek, Benno T1 - Chandehari, M., Self-Circumference of rotors Y1 - 1996 ER - TY - GEN A1 - Krause, Andreas A1 - Kloft, Charlotte A1 - Huisinga, Wilhelm A1 - Karlsson, Mats A1 - Pinheiro, José A1 - Bies, Robert A1 - Rogers, James A1 - Mentré, France A1 - Musser, Bret J. T1 - Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development T2 - Pharmaceutical statistics : the journal of applied statistics in the pharmaceutical industry Y1 - 2019 SN - 1539-1604 SN - 1539-1612 VL - 18 IS - 3 SP - 278 EP - 281 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Osterloha, Lukas A1 - Böckmann, Christine A1 - Nicolae, Doina A1 - Nemuc, Anca T1 - Regularized inversion of microphysical atmospheric particle parameters: Theory and application (vol 237, pg 79, 2013) T2 - Journal of computational physics Y1 - 2014 U6 - https://doi.org/10.1016/j.jcp.2014.07.041 SN - 0021-9991 SN - 1090-2716 VL - 275 SP - 696 EP - 696 PB - Elsevier CY - San Diego ER - TY - GEN A1 - Paycha, Sylvie T1 - Interview with Pierre Cartier BT - Potsdam, December 4th, 2014 T2 - The mathematical intelligencer Y1 - 2016 U6 - https://doi.org/10.1007/s00283-016-9673-y SN - 0343-6993 SN - 1866-7414 VL - 39 SP - 15 EP - 21 PB - Springer CY - New York ER - TY - GEN A1 - Pfäffle, Frank A1 - Stephan, Christoph A. T1 - The holst action by the spectral action principle (vol 307, pg 261, 2011) T2 - Communications in mathematical physics Y1 - 2012 U6 - https://doi.org/10.1007/s00220-012-1507-y SN - 0010-3616 VL - 313 IS - 1 SP - 291 EP - 292 PB - Springer CY - New York ER - TY - GEN A1 - Quaisser, Erhard T1 - Greewell, D. ; Johnson, P. D., Geombinatorics,2 (1993), 3, S. 61 - 64 BT - Geombinatorics Y1 - 1996 ER - TY - GEN A1 - Quaisser, Erhard T1 - Grünbaum, B., Geombinatorics, 4 (1995), 3, S. 77 - 79 BT - Geombinatorics Y1 - 1995 ER - TY - GEN A1 - Quaisser, Erhard T1 - Coxeter, A. S. M., Linear algebra and its applications, 226-228 (1995), S. 375 - 388 BT - Linear algebra and its applications Y1 - 1995 ER - TY - GEN A1 - Quaisser, Erhard T1 - Quan, L., Journal of mathematical imaging and vision, 5 (1995), S. 263 - 267 BT - Journal of mathematical imaging and vision Y1 - 1995 ER - TY - GEN A1 - Quaisser, Erhard T1 - Jeurissen, R. H., Linear algebra appl., 226/228 (1995), S. 617 - 638 BT - Linear algebra appl. Y1 - 1995 ER - TY - GEN A1 - Quaisser, Erhard T1 - Payne, S.R., Linear algebra appl., 226/228 (1995), S. 115 - 137 BT - Linear algebra appl. Y1 - 1995 ER - TY - GEN A1 - Quaisser, Erhard T1 - Antoni, C. ; Dalena, A., Discrete applied mathematics, 66 (1996), S. 75 - 79 BT - Discrete applied mathematics Y1 - 1996 ER - TY - GEN A1 - Quaisser, Erhard T1 - Kuperberg, W., Discrete and Computational Geometry, 12 (1994), S. 83 - 90 BT - Discrete and Computational Geometry Y1 - 1994 ER - TY - GEN A1 - Strader, Anne A1 - Schneider, Max A1 - Schorlemmer, Danijel T1 - Erratum zu: Strader, Anne; Schneider, Max; Schorlemmer, Danijel: Prospective and retrospective evaluation of five-year earthquake forecast models for California (Geophysical Journal International, 211 (2017) 1, S. 239 – 251, https://doi.org/10.1093/gji/ggx268) T2 - Geophysical journal international N2 - S-test results for the USGS and RELM forecasts. The differences between the simulated log-likelihoods and the observed log-likelihood are labelled on the horizontal axes, with scaling adjustments for the 40year.retro experiment. The horizontal lines represent the confidence intervals, within the 0.05 significance level, for each forecast and experiment. If this range contains a log-likelihood difference of zero, the forecasted log-likelihoods are consistent with the observed, and the forecast passes the S-test (denoted by thin lines). If the minimum difference within this range does not contain zero, the forecast fails the S-test for that particular experiment, denoted by thick lines. Colours distinguish between experiments (see Table 2 for explanation of experiment durations). Due to anomalously large likelihood differences, S-test results for Wiemer-Schorlemmer.ALM during the 10year.retro and 40year.retro experiments are not displayed. The range of log-likelihoods for the Holliday-et-al.PI forecast is lower than for the other forecasts due to relatively homogeneous forecasted seismicity rates and use of a small fraction of the RELM testing region. Y1 - 2017 U6 - https://doi.org/10.1093/gji/ggx496 SN - 0956-540X SN - 1365-246X VL - 212 IS - 2 SP - 1314 EP - 1314 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Weisser, Karin A1 - Stübler, Sabine A1 - Matheis, Walter A1 - Huisinga, Wilhelm T1 - Towards toxicokinetic modelling of aluminium exposure from adjuvants in medicinal products T2 - Regulatory toxicology and pharmacology : official journal of the International Society for Regulatory Toxicology and Pharmacology N2 - As a potentially toxic agent on nervous system and bone, the safety of aluminium exposure from adjuvants in vaccines and subcutaneous immune therapy (SCIT) products has to be continuously reevaluated, especially regarding concomitant administrations. For this purpose, knowledge on absorption and disposition of aluminium in plasma and tissues is essential. Pharmacokinetic data after vaccination in humans, however, are not available, and for methodological and ethical reasons difficult to obtain. To overcome these limitations, we discuss the possibility of an in vitro-in silico approach combining a toxicokinetic model for aluminium disposition with biorelevant kinetic absorption parameters from adjuvants. We critically review available kinetic aluminium-26 data for model building and, on the basis of a reparameterized toxicokinetic model (Nolte et al., 2001), we identify main modelling gaps. The potential of in vitro dissolution experiments for the prediction of intramuscular absorption kinetics of aluminium after vaccination is explored. It becomes apparent that there is need for detailed in vitro dissolution and in vivo absorption data to establish an in vitro-in vivo correlation (IVIVC) for aluminium adjuvants. We conclude that a combination of new experimental data and further refinement of the Nolte model has the potential to fill a gap in aluminium risk assessment. (C) 2017 Elsevier Inc. All rights reserved. KW - Aluminium KW - Aluminium adjuvants KW - Absorption kinetics KW - Toxicokinetic modelling KW - In vitro dissolution Y1 - 2017 U6 - https://doi.org/10.1016/j.yrtph.2017.02.018 SN - 0273-2300 SN - 1096-0295 VL - 88 SP - 310 EP - 321 PB - Elsevier CY - San Diego ER - TY - GEN A1 - Wicha, Sebastian G. A1 - Kees, Martin G. A1 - Solms, Alexander Maximilian A1 - Minichmayr, Iris K. A1 - Kratzer, Alexander A1 - Kloft, Charlotte T1 - TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine T2 - International journal of antimicrobial agents Y1 - 2015 U6 - https://doi.org/10.1016/j.ijantimicag.2014.12.010 SN - 0924-8579 SN - 1872-7913 VL - 45 IS - 4 SP - 442 EP - 444 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Yin, Yang A1 - Hua, Chen T1 - On chemotaxis systems with saturation growth T2 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2007 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - GEN A1 - Zöller, Gert A1 - Holschneider, Matthias T1 - Reply to “Comment on ‘The Maximum Possible and the Maximum Expected Earthquake Magnitude for Production‐Induced Earthquakes at the Gas Field in Groningen, The Netherlands’ by Gert Zöller and Matthias Holschneider” by Mathias Raschke T2 - Bulletin of the Seismological Society of America Y1 - 2018 U6 - https://doi.org/10.1785/0120170131 SN - 0037-1106 SN - 1943-3573 VL - 108 IS - 2 SP - 1029 EP - 1030 PB - Seismological Society of America CY - Albany ER -