TY  - JOUR
A1  - Abdissa, Negera
A1  - Induli, Martha
A1  - Akala, Hoseah M.
A1  - Heydenreich, Matthias
A1  - Midiwo, Jacob O.
A1  - Ndakala, Albert
A1  - Yenesew, Abiy
T1  - Knipholone cyclooxanthrone and an anthraquinone dimer with antiplasmodial activities from the roots of Kniphofia foliosa
JF  - Phytochemistry letters
N2  - A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively.
KW  - Kniphofia foliosa
KW  - Asphodelaceae
KW  - Roots
KW  - Anthraquinone
KW  - Knipholone cyclooxanthrone
KW  - 10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol
KW  - Dianellin
KW  - Malaria
Y1  - 2013
U6  - https://doi.org/10.1016/j.phytol.2013.02.005
SN  - 1874-3900
VL  - 6
IS  - 2
SP  - 241
EP  - 245
PB  - Elsevier
CY  - Amsterdam
ER  -