TY  - JOUR
A1  - Acharya, B. S.
A1  - Aramo, C.
A1  - Babic, A.
A1  - Barrio, J. A.
A1  - Baushev, Anton N.
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bohacova, M.
A1  - Bonardi, A.
A1  - Brown, A.
A1  - Bugaev, V.
A1  - Bulik, Tomasz
A1  - Burton, M.
A1  - Busetto, G.
A1  - Caraveo, P. A.
A1  - Carosi, R.
A1  - Carr, John
A1  - Chadwick, Paula M.
A1  - Chudoba, J.
A1  - Conforti, V.
A1  - Connaughton, V.
A1  - Contreras, J. L.
A1  - Cotter, G.
A1  - Dazzi, F.
A1  - De Franco, A.
A1  - de la Calle, I.
A1  - Lopez, R. de los Reyes
A1  - De Lotto, B.
A1  - De Palma, F.
A1  - Di Girolamo, T.
A1  - Di Giulio, C.
A1  - Di Pierro, F.
A1  - Dournaux, J. -L.
A1  - Dwarkadas, Vikram V.
A1  - Ebr, J.
A1  - Egberts, Kathrin
A1  - Fesquet, M.
A1  - Fleischhack, H.
A1  - Font, L.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Füßling, Matthias
A1  - Garcia, B.
A1  - Lopez, R. Garcia
A1  - Garczarczyk, M.
A1  - Gargano, F.
A1  - Garrido, D.
A1  - Gaug, M.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giuliani, A.
A1  - Godinovic, N.
A1  - Gonzalez, M. M.
A1  - Grabarczyk, T.
A1  - Hassan, T.
A1  - Hoerandel, J.
A1  - Hrabovsky, M.
A1  - Hrupec, D.
A1  - Humensky, T. B.
A1  - Huovelin, J.
A1  - Jamrozy, M.
A1  - Janecek, P.
A1  - Kaaret, P. E.
A1  - Katz, U.
A1  - Kaufmann, S.
A1  - Khelifi, B.
A1  - Kluzniak, W.
A1  - Kocot, J.
A1  - Komin, N.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - Lamanna, G.
A1  - Lee, W. H.
A1  - Lenain, J. -P.
A1  - Lohse, T.
A1  - Lombardi, S.
A1  - Lopez-Coto, R.
A1  - Lopez-Oramas, A.
A1  - Lucarelli, F.
A1  - Maccarone, M. C.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - Malaguti, G.
A1  - Mandat, D.
A1  - Mazziotta, Mario Nicola
A1  - Meagher, K.
A1  - Mirabal, N.
A1  - Morselli, A.
A1  - Moulin, E.
A1  - Niemiec, J.
A1  - Nievas, M.
A1  - Nishijima, K.
A1  - Nosek, D.
A1  - Nunio, F.
A1  - Ohishi, M.
A1  - Ohm, S.
A1  - Ong, R. A.
A1  - Orito, R.
A1  - Otte, N.
A1  - Palatka, M.
A1  - Pareschi, G.
A1  - Pech, M.
A1  - Persic, M.
A1  - Pohl, Manuela
A1  - Prouza, M.
A1  - Quirrenbach, A.
A1  - Raino, S.
A1  - Fernandez, G. Rodriguez
A1  - Romano, Patrizia
A1  - Rovero, A. C.
A1  - Rudak, B.
A1  - Schovanek, P.
A1  - Shayduk, M.
A1  - Siejkowski, H.
A1  - Sillanpaa, A.
A1  - Stefanik, S.
A1  - Stolarczyk, T.
A1  - Szanecki, M.
A1  - Szepieniec, T.
A1  - Tejedor, L. A.
A1  - Telezhinsky, Igor O.
A1  - Teshima, M.
A1  - Tibaldo, L.
A1  - Tibolla, O.
A1  - Tovmassian, G.
A1  - Travnicek, P.
A1  - Trzeciak, M.
A1  - Vallania, P.
A1  - van Eldik, C.
A1  - Vercellone, S.
A1  - Vigorito, C.
A1  - Wagner, S. J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wierzcholska, A.
A1  - Wilhelm, Alina
A1  - Wojcik, P.
A1  - Yoshikoshi, T.
T1  - The Cherenkov Telescope Array potential for the study of young supernova remnants
JF  - Astroparticle physics
N2  - Supernova remnants (SNRs) are among the most important targets for gamma-ray observatories. Being prominent non-thermal sources, they are very likely responsible for the acceleration of the bulk of Galactic cosmic rays (CRS). To firmly establish the SNR paradigm for the origin of cosmic rays, it should be confirmed that protons are indeed accelerated in, and released from, SNRs with the appropriate flux and spectrum. This can be done by detailed theoretical models which account for microphysics of acceleration and various radiation processes of hadrons and leptons. The current generation of Cherenkov telescopes has insufficient sensitivity to constrain theoretical models. A new facility, the Cherenkov Telescope Array (CTA), will have superior capabilities and may finally resolve this long standing issue of high-energy astrophysics. We want to assess the capabilities of CTA to reveal the physics of various types of SNRs in the initial 2000 years of their evolution. During this time, the efficiency to accelerate cosmic rays is highest. We perform time-dependent simulations of the hydrodynamics, the magnetic fields, the cosmic-ray acceleration, and the non-thermal emission for type Ia, Ic and IIP SNRs. We calculate the CTA response to the y-ray emission from these SNRs for various ages and distances, and we perform a realistic analysis of the simulated data. We derive distance limits for the detectability and resolvability of these SNR types at several ages. We test the ability of CTA to reconstruct their morphological and spectral parameters as a function of their distance. Finally, we estimate how well CTA data will constrain the theoretical models. (C) 2014 Elsevier B.V. All rights reserved.
KW  - Acceleration of particles
KW  - Gamma rays: General
KW  - ISM: Supernova remnants
KW  - Radiation mechanisms: Non-termal
Y1  - 2015
U6  - https://doi.org/10.1016/j.astropartphys.2014.08.005
SN  - 0927-6505
SN  - 1873-2852
VL  - 62
SP  - 152
EP  - 164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Aguzzi, Jacopo
A1  - Costa, C.
A1  - Ketmaier, V.
A1  - Angelini, C.
A1  - Antonucci, F.
A1  - Menesatti, P.
A1  - Company, J. B.
T1  - Light-dependent genetic and phenotypic differences in the squat lobster Munida tenuimana (Crustacea: Decapoda) along deep continental margins
JF  - Progress in oceanography
N2  - The levels of environmental light experienced by organisms during the behavioral activity phase deeply influence the performance of important ecological tasks. As a result, their shape and coloring may experience a light-driven selection process via the day-night rhythmic behavior. In this study, we tested the phenotypic and genetic variability of the western Mediterranean squat lobster (Munida tenuimana). We sampled at depths with different photic conditions and potentially, different burrow emergence rhythms. We performed day-night hauling at different depths, above and below the twilight zone end (i.e., 700 m, 1200 m, 1350 m, and 1500 m), to portray the occurrence of any burrow emergence rhythmicity. Collected animals were screened for shape and size (by geometric morphometry), spectrum and color variation (by photometric analysis), as well as for sequence variation at the mitochondria] DNA gene encoding for the NADH dehydrogenase subunit I. We found that a weak genetic structuring and shape homogeneity occurred together with significant variations in size, with the smaller individuals living at the twilight zone inferior limit and the larger individuals above and below. The infra-red wavelengths of spectral reflectance varied significantly with depth while the blue-green ones were size-dependent and expressed in smaller animals, which has a very small spectral reflectance. The effects of solar and bioluminescence lighting are discussed as depth-dependent evolutionary forces likely influencing the behavioral rhythms and coloring of M. tenuimana.
Y1  - 2013
U6  - https://doi.org/10.1016/j.pocean.2013.07.011
SN  - 0079-6611
VL  - 118
IS  - 4
SP  - 199
EP  - 209
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Albrecht, Clemens
T1  - Garrioch, D., The formation of the Parisian bourgeoisie 1690 - 1830; Cambridge, Harvard Univ. Press, 1996
BT  - The formation of the Parisian bourgeoisie 1690 - 1830
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Albrecht, Clemens
T1  - Beik, W., Urban protest in seventeenth century France; Cambridge, Cambridge Univ. Press, 1997
BT  - Urban protest in seventeenth century France
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Antonietti, Markus
A1  - Lopez-Salas, Nieves
A1  - Primo, Ana
T1  - Adjusting the Structure and Electronic Properties of Carbons for Metal-Free Carbocatalysis of Organic Transformations
JF  - Advanced materials
N2  - Carbon nanomaterials doped with some other lightweight elements were recently described as powerful, heterogeneous, metal-free organocatalysts, adding to their high performance in electrocatalysis. Here, recent observations in traditional catalysis are reviewed, and the underlying reaction mechanisms of the catalyzed organic transformations are explored. In some cases, these are due to specific active functional sites, but more generally the catalytic activity relates to collective properties of the conjugated nanocarbon frameworks and the electron transfer from and to the catalytic centers and substrates. It is shown that the !earnings are tightly related to those of electrocatalysis; i.e., the search for better electrocatalysts also improves chemocatalysis, and vice versa. Carbon-carbon heterojunction effects and some perspectives on future possibilities are discussed at the end.
KW  - active sites
KW  - carbocatalysis
KW  - carbon electrical collective properties
KW  - metal-free
KW  - nanocarbon materials
Y1  - 2018
U6  - https://doi.org/10.1002/adma.201805719
SN  - 0935-9648
SN  - 1521-4095
VL  - 31
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Apriyanto, Ardha
A1  - Compart, Julia
A1  - Fettke, Jörg
T1  - A review of starch, a unique biopolymer - structure, metabolism and in planta modifications
JF  - Plant science : an international journal of experimental plant biology
N2  - Starch is a complex carbohydrate polymer produced by plants and especially by crops in huge amounts. It consists of amylose and amylopectin, which have alpha-1,4-and alpha-1,6-linked glucose units. Despite this simple chemistry, the entire starch metabolism is complex, containing various (iso)enzymes/proteins. However, whose interplay is still not yet fully understood. Starch is essential for humans and animals as a source of nutrition and energy. Nowadays, starch is also commonly used in non-food industrial sectors for a variety of purposes. However, native starches do not always satisfy the needs of a wide range of (industrial) applications. This review summarizes the structural properties of starch, analytical methods for starch characterization, and in planta starch modifications.
KW  - starch
KW  - starch structure
KW  - starch surface
KW  - starch modifications;
KW  - analytics
Y1  - 2022
U6  - https://doi.org/10.1016/j.plantsci.2022.111223
SN  - 0168-9452
SN  - 1873-2259
VL  - 318
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Arias-Andres, Maria
A1  - Rojas-Jimenez, Keilor
A1  - Grossart, Hans-Peter
T1  - Collateral effects of microplastic pollution on aquatic microorganisms
BT  - An ecological perspective
JF  - Trends in Analytical Chemistry
N2  - Microplastics (MP) provide a unique and extensive surface for microbial colonization in aquatic ecosystems. The formation of microorganism-microplastic complexes, such as biofilms, maximizes the degradation of organic matter and horizontal gene transfer. In this context, MP affect the structure and function of microbial communities, which in turn render the physical and chemical fate of MP. This new paradigm generates challenges for microbiology, ecology, and ecotoxicology. Dispersal of MP is concomitant with that of their associated microorganisms and their mobile genetic elements, including antibiotic resistance genes, islands of pathogenicity, and diverse metabolic pathways. Functional changes in aquatic microbiomes can alter carbon metabolism and food webs, with unknown consequences on higher organisms or human microbiomes and hence health. Here, we examine a variety of effects of MP pollution from the microbial ecology perspective, whose repercussions on aquatic ecosystems begin to be unraveled. (C) 2018 Elsevier B.V. All rights reserved.
KW  - Microplastics (MP)
KW  - Biofilms
KW  - HGT
KW  - Microbial ecology
KW  - Carbon cycling
KW  - Aquatic ecosystems
KW  - Health risk assessment
Y1  - 2018
U6  - https://doi.org/10.1016/j.trac.2018.11.041
SN  - 0165-9936
SN  - 1879-3142
VL  - 112
SP  - 234
EP  - 240
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Ariel, Yaakov S.
T1  - Ismar Schorsch: Leopold Zunz. Creativity in Adversity / [rezensiert von] Yaakov Ariel
JF  - PaRDES : Zeitschrift der Vereinigung für Jüdische Studien e. V.
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-417918
SP  - 239
EP  - 241
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Arlt, Olga
A1  - Schwiebs, Anja
A1  - Japtok, Lukasz
A1  - Rueger, Katja
A1  - Katzy, Elisabeth
A1  - Kleuser, Burkhard
A1  - Radeke, Heinfried H.
T1  - Sphingosine-1-Phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DC homeostasis and the role of SIP and SW metabolism in inflammatory diseases.
KW  - Sphingosine-1-phosphate
KW  - Dendritic cells
KW  - Fingolimod
KW  - IL-12
KW  - Inflammation
Y1  - 2014
U6  - https://doi.org/10.1159/000362982
SN  - 1015-8987
SN  - 1421-9778
VL  - 34
IS  - 1
SP  - 27
EP  - 44
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Arnison, Paul G.
A1  - Bibb, Mervyn J.
A1  - Bierbaum, Gabriele
A1  - Bowers, Albert A.
A1  - Bugni, Tim S.
A1  - Bulaj, Grzegorz
A1  - Camarero, Julio A.
A1  - Campopiano, Dominic J.
A1  - Challis, Gregory L.
A1  - Clardy, Jon
A1  - Cotter, Paul D.
A1  - Craik, David J.
A1  - Dawson, Michael
A1  - Dittmann-Thünemann, Elke
A1  - Donadio, Stefano
A1  - Dorrestein, Pieter C.
A1  - Entian, Karl-Dieter
A1  - Fischbach, Michael A.
A1  - Garavelli, John S.
A1  - Goeransson, Ulf
A1  - Gruber, Christian W.
A1  - Haft, Daniel H.
A1  - Hemscheidt, Thomas K.
A1  - Hertweck, Christian
A1  - Hill, Colin
A1  - Horswill, Alexander R.
A1  - Jaspars, Marcel
A1  - Kelly, Wendy L.
A1  - Klinman, Judith P.
A1  - Kuipers, Oscar P.
A1  - Link, A. James
A1  - Liu, Wen
A1  - Marahiel, Mohamed A.
A1  - Mitchell, Douglas A.
A1  - Moll, Gert N.
A1  - Moore, Bradley S.
A1  - Mueller, Rolf
A1  - Nair, Satish K.
A1  - Nes, Ingolf F.
A1  - Norris, Gillian E.
A1  - Olivera, Baldomero M.
A1  - Onaka, Hiroyasu
A1  - Patchett, Mark L.
A1  - Piel, Jörn
A1  - Reaney, Martin J. T.
A1  - Rebuffat, Sylvie
A1  - Ross, R. Paul
A1  - Sahl, Hans-Georg
A1  - Schmidt, Eric W.
A1  - Selsted, Michael E.
A1  - Severinov, Konstantin
A1  - Shen, Ben
A1  - Sivonen, Kaarina
A1  - Smith, Leif
A1  - Stein, Torsten
A1  - Suessmuth, Roderich D.
A1  - Tagg, John R.
A1  - Tang, Gong-Li
A1  - Truman, Andrew W.
A1  - Vederas, John C.
A1  - Walsh, Christopher T.
A1  - Walton, Jonathan D.
A1  - Wenzel, Silke C.
A1  - Willey, Joanne M.
A1  - van der Donk, Wilfred A.
T1  - Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature
JF  - Natural product reports : a journal of current developments in bio-organic chemistry
N2  - This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
Y1  - 2013
U6  - https://doi.org/10.1039/c2np20085f
SN  - 0265-0568
VL  - 30
IS  - 1
SP  - 108
EP  - 160
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Arnold, Anne
A1  - Nikoloski, Zoran
T1  - A quantitative comparison of Calvin-Benson cycle models
JF  - Trends in plant science
N2  - The Calvin-Benson cycle (CBC) provides the precursors for biomass synthesis necessary for plant growth. The dynamic behavior and yield of the CBC depend on the environmental conditions and regulation of the cellular state. Accurate quantitative models hold the promise of identifying the key determinants of the tightly regulated CBC function and their effects on the responses in future climates. We provide an integrative analysis of the largest compendium of existing models for photosynthetic processes. Based on the proposed ranking, our framework facilitates the discovery of best-performing models with regard to metabolomics data and of candidates for metabolic engineering.
Y1  - 2011
U6  - https://doi.org/10.1016/j.tplants.2011.09.004
SN  - 1360-1385
VL  - 16
IS  - 12
SP  - 676
EP  - 683
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Arnold, Rafael D.
T1  - Leshonot yehude Sefarad ve-ha-mizrach vesifruyotehem / Languages and literatures of Sephardic and Oriental Jews / [rezensiert von] Rafael Arnold
N2  - rezensiertes Werk: Leshonot yehude Sefarad ve-ha-mizrach vesifruyotehem / Languages and literatures of Sephardic and Oriental Jews. - Jerusalem : Misgav Yerushalayim, 2009. - 484 S. [hebr.] + 434 S. [lat.], ; Ill.
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-43777
SN  - 1614-6492
SN  - 1862-7684
IS  - 16
SP  - 240
EP  - 244
ER  - 
TY  - JOUR
A1  - Aschner, Michael A.
A1  - Palinski, Catherine
A1  - Sperling, Michael
A1  - Karst, U.
A1  - Schwerdtle, Tanja
A1  - Bornhorst, Julia
T1  - Imaging metals in Caenorhabditis elegans
JF  - Metallomics : integrated biometal science
N2  - Systemic trafficking and storage of essential metal ions play fundamental roles in living organisms by serving as essential cofactors in various cellular processes. Thereby metal quantification and localization are critical steps in understanding metal homeostasis, and how their dyshomeostasis might contribute to disease etiology and the ensuing pathologies. Furthermore, the amount and distribution of metals in organisms can provide insight into their underlying mechanisms of toxicity and toxicokinetics. While in vivo studies on metal imaging in mammalian experimental animals are complex, time- and resource-consuming, the nematode Caenorhabditis elegans (C. elegans) provides a suitable comparative and complementary model system. Expressing homologous genes to those inherent to mammals, including those that regulate metal homeostasis and transport, C. elegans has become a powerful tool to study metal homeostasis and toxicity. A number of recent technical advances have been made in the development and application of analytical methods to visualize metal ions in C. elegans. Here, we briefly summarize key findings and challenges of the three main techniques and their application to the nematode, namely sensing fluorophores, microbeam synchrotron radiation X-ray fluorescence as well as laser ablation ( LA) coupled to inductively coupled plasma-mass spectrometry (ICP-MS).
Y1  - 2017
U6  - https://doi.org/10.1039/c6mt00265j
SN  - 1756-5901
SN  - 1756-591X
VL  - 9
SP  - 357
EP  - 364
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Ast, Cindy
A1  - Schmälzlin, Elmar
A1  - Löhmannsröben, Hans-Gerd
A1  - van Dongen, Joost T.
T1  - Optical oxygen micro- and nanosensors for plant applications
JF  - Sensors
N2  - Pioneered by Clark's microelectrode more than half a century ago, there has been substantial interest in developing new, miniaturized optical methods to detect molecular oxygen inside cells. While extensively used for animal tissue measurements, applications of intracellular optical oxygen biosensors are still scarce in plant science. A critical aspect is the strong autofluorescence of the green plant tissue that interferes with optical signals of commonly used oxygen probes. A recently developed dual-frequency phase modulation technique can overcome this limitation, offering new perspectives for plant research. This review gives an overview on the latest optical sensing techniques and methods based on phosphorescence quenching in diverse tissues and discusses the potential pitfalls for applications in plants. The most promising oxygen sensitive probes are reviewed plus different oxygen sensing structures ranging from micro-optodes to soluble nanoparticles. Moreover, the applicability of using heterologously expressed oxygen binding proteins and fluorescent proteins to determine changes in the cellular oxygen concentration are discussed as potential non-invasive cellular oxygen reporters.
KW  - oxygen sensor
KW  - biosensors
KW  - microsensors
KW  - nanosensors
KW  - endogenous sensor proteins
KW  - dual-frequency phase-modulation
KW  - phosphorescence quenching
KW  - plant science
Y1  - 2012
U6  - https://doi.org/10.3390/s120607015
SN  - 1424-8220
VL  - 12
IS  - 6
SP  - 7015
EP  - 7032
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Ast, Sandra
A1  - Fischer, Tobias
A1  - Müller, Holger
A1  - Mickler, Wulfhard
A1  - Schwichtenberg, Mathias
A1  - Rurack, Knut
A1  - Holdt, Hans-Jürgen
T1  - Integration of the 1,2,3-Triazole "Click" Motif as a potent signalling element in metal ion responsive fluorescent probes
JF  - Chemistry - a European journal
N2  - In a systematic approach we synthesized a new series of fluorescent probes incorporating donoracceptor (D-A) substituted 1,2,3-triazoles as conjugative -linkers between the alkali metal ion receptor N-phenylaza-[18]crown-6 and different fluorophoric groups with different electron-acceptor properties (4-naphthalimide, meso-phenyl-BODIPY and 9-anthracene) and investigated their performance in organic and aqueous environments (physiological conditions). In the charge-transfer (CT) type probes 1, 2 and 7, the fluorescence is almost completely quenched by intramolecular CT (ICT) processes involving charge-separated states. In the presence of Na+ and K+ ICT is interrupted, which resulted in a lighting-up of the fluorescence in acetonitrile. Among the investigated fluoroionophores, compound 7, which contains a 9-anthracenyl moiety as the electron-accepting fluorophore, is the only probe which retains light-up features in water and works as a highly K+/Na+-selective probe under simulated physiological conditions. Virtually decoupled BODIPY-based 6 and photoinduced electron transfer (PET) type probes 35, where the 10-substituted anthracen-9-yl fluorophores are connected to the 1,2,3-triazole through a methylene spacer, show strong ion-induced fluorescence enhancement in acetonitrile, but not under physiological conditions. Electrochemical studies and theoretical calculations were used to assess and support the underlying mechanisms for the new ICT and PET 1,2,3-triazole fluoroionophores.
KW  - charge transfer
KW  - click chemistry
KW  - electron transfer
KW  - fluorescent probes
KW  - metal ions
Y1  - 2013
U6  - https://doi.org/10.1002/chem.201201575
SN  - 0947-6539
VL  - 19
IS  - 9
SP  - 2990
EP  - 3005
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Augusiak, Jacqueline
A1  - Van den Brink, Paul J.
A1  - Grimm, Volker
T1  - Merging validation and evaluation of ecological models to 'evaludation': A review of terminology and a practical approach
JF  - Ecological modelling : international journal on ecological modelling and engineering and systems ecolog
N2  - Confusion about model validation is one of the main challenges in using ecological models for decision support, such as the regulation of pesticides. Decision makers need to know whether a model is a sufficiently good representation of its real counterpart and what criteria can be used to answer this question. Unclear terminology is one of the main obstacles to a good understanding of what model validation is, how it works, and what it can deliver. Therefore, we performed a literature review and derived a standard set of terms. 'Validation' was identified as a catch-all term, which is thus useless for any practical purpose. We introduce the term 'evaludation', a fusion of 'evaluation' and 'validation', to describe the entire process of assessing a model's quality and reliability. Considering the iterative nature of model development, the modelling cycle, we identified six essential elements of evaludation: (i) 'data evaluation' for scrutinising the quality of numerical and qualitative data used for model development and testing; (ii) 'conceptual model evaluation' for examining the simplifying assumptions underlying a model's design; (iii) 'implementation verification' for testing the model's implementation in equations and as a computer programme; (iv) 'model output verification' for comparing model output to data and patterns that guided model design and were possibly used for calibration; (v) 'model analysis' for exploring the model's sensitivity to changes in parameters and process formulations to make sure that the mechanistic basis of main behaviours of the model has been well understood; and (vi) 'model output corroboration' for comparing model output to new data and patterns that were not used for model development and parameterisation. Currently, most decision makers require 'validating' a model by testing its predictions with new experiments or data. Despite being desirable, this is neither sufficient nor necessary for a model to be useful for decision support. We believe that the proposed set of terms and its relation to the modelling cycle can help to make quality assessments and reality checks of ecological models more comprehensive and transparent. (C) 2013 Elsevier B.V. All rights reserved.
KW  - Model validation
KW  - Terminology
KW  - Decision support
KW  - Documentation
KW  - Ecological models
KW  - Risk assessment
Y1  - 2014
U6  - https://doi.org/10.1016/j.ecolmodel.2013.11.009
SN  - 0304-3800
SN  - 1872-7026
VL  - 280
SP  - 117
EP  - 128
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Avalli, Andrea
ED  - Ambühl, Annemarie
ED  - Carlà-Uhink, Filippo
ED  - Rollinger, Christian
ED  - Walde, Christine
T1  - Review of Dario Barbera: Processo al Classico. L’epurazione dell’archeologia fascista
BT  - ETS (Pisa 2022) (= Studi di archeologia e storia del mondo antico e medievale), 264 pp. ISBN: 9788846762191, € 25
JF  - thersites 16
Y1  - 2023
U6  - https://doi.org/10.34679/thersites.vol16.233
SN  - 2364-7612
VL  - 2023
IS  - 16
SP  - 168
EP  - 172
ER  - 
TY  - JOUR
A1  - Ayllon, Daniel
A1  - Grimm, Volker
A1  - Attinger, Sabine
A1  - Hauhs, Michael
A1  - Simmer, Clemens
A1  - Vereecken, Harry
A1  - Lischeid, Gunnar
T1  - Cross-disciplinary links in environmental systems science
BT  - Current state and claimed needs identified in a meta-review of process models
JF  - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2  - Terrestrial environmental systems are characterised by numerous feedback links between their different compartments. However, scientific research is organized into disciplines that focus on processes within the respective compartments rather than on interdisciplinary links. Major feedback mechanisms between compartments might therefore have been systematically overlooked so far. Without identifying these gaps, initiatives on future comprehensive environmental monitoring schemes and experimental platforms might fail. We performed a comprehensive overview of feedbacks between compartments currently represented in environmental sciences and explores to what degree missing links have already been acknowledged in the literature. We focused on process models as they can be regarded as repositories of scientific knowledge that compile findings of numerous single studies. In total, 118 simulation models from 23 model types were analysed. Missing processes linking different environmental compartments were identified based on a meta-review of 346 published reviews, model inter-comparison studies, and model descriptions. Eight disciplines of environmental sciences were considered and 396 linking processes were identified and ascribed to the physical, chemical or biological domain. There were significant differences between model types and scientific disciplines regarding implemented interdisciplinary links. The most wide-spread interdisciplinary links were between physical processes in meteorology, hydrology and soil science that drive or set the boundary conditions for other processes (e.g., ecological processes). In contrast, most chemical and biological processes were restricted to links within the same compartment. Integration of multiple environmental compartments and interdisciplinary knowledge was scarce in most model types. There was a strong bias of suggested future research foci and model extensions towards reinforcing existing interdisciplinary knowledge rather than to open up new interdisciplinary pathways. No clear pattern across disciplines exists with respect to suggested future research efforts. There is no evidence that environmental research would clearly converge towards more integrated approaches or towards an overarching environmental systems theory. (c) 2017 Elsevier B.V. All rights reserved.
KW  - Review
KW  - Interdisciplinary links
KW  - Integrated environmental modelling
KW  - Research needs
Y1  - 2018
U6  - https://doi.org/10.1016/j.scitotenv.2017.12.007
SN  - 0048-9697
SN  - 1879-1026
VL  - 622
SP  - 954
EP  - 973
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bacskai-Atkari, Julia
T1  - Descriptive typology and linguistic theory: A study in the morphosyntax of relative clauses
JF  - Acta linguistica Hungarica : an international journal of linguistics
Y1  - 2016
SN  - 1216-8076
SN  - 1588-2624
VL  - 63
SP  - 97
EP  - 112
PB  - Akadémiai Kiadó
CY  - Budapest
ER  - 
TY  - JOUR
A1  - Bacskai-Atkari, Julia
T1  - Syntax over Time. Lexical, Morphological, and Information - Structural Interactions
JF  - Beiträge zur Geschichte der deutschen Sprache und Literatur
Y1  - 2016
U6  - https://doi.org/10.1515/bgsl-2016-0020
SN  - 0005-8076
SN  - 1865-9373
VL  - 138
SP  - 264
EP  - 271
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bald, Ilko
A1  - Keller, Adrian
T1  - Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy
JF  - Molecules
N2  - DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
KW  - DNA origami
KW  - atomic force microscopy
KW  - single-molecule analysis
KW  - DNA radiation damage
KW  - protein binding
KW  - enzyme reactions
KW  - G quadruplexes
Y1  - 2014
U6  - https://doi.org/10.3390/molecules190913803
SN  - 1420-3049
VL  - 19
IS  - 9
SP  - 13803
EP  - 13823
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Baldermann, Susanne
A1  - Blagojevic, Lara
A1  - Frede, Katja
A1  - Klopsch, R.
A1  - Neugart, Susanne
A1  - Neumann, A.
A1  - Ngwene, Benard
A1  - Norkeweit, Jessica
A1  - Schroeter, D.
A1  - Schroeter, A.
A1  - Schweigert, Florian J.
A1  - Wiesner, M.
A1  - Schreiner, Monika
T1  - Are Neglected Plants the Food for the Future?
JF  - Critical reviews in plant sciences
N2  - Malnutrition, poor health, hunger, and even starvation are still the world's greatest challenges. Malnutrition is defined as deficiency of nutrition due to not ingesting the proper amounts of nutrients by simply not eating enough food and/or by consuming nutrient-poor food in respect to the daily nutritional requirements. Moreover, malnutrition and disease are closely associated and incidences of such diet-related diseases increase particularly in low- and middle-income states. While foods of animal origin are often unaffordable to low-income families, various neglected crops can offer an alternative source of micronutrients, vitamins, as well as health-promoting secondary plant metabolites. Therefore, agricultural and horticultural research should develop strategies not only to produce more food, but also to improve access to more nutritious food. In this context, one promising approach is to promote biodiversity in the dietary pattern of low-income people by getting access to nutritional as well as affordable food and providing recommendations for food selection and preparation. Worldwide, a multitude of various plant species are assigned to be consumed as grains, vegetables, and fruits, but only a limited number of these species are used as commercial cash crops. Consequently, numerous neglected and underutilized species offer the potential to diversify not only the human diet, but also increase food production levels, and, thus, enable more sustainable and resilient agro- and horti-food systems. To exploit the potential of neglected plant (NP) species, coordinated approaches on the local, regional, and international level have to be integrated that consequently demand the involvement of numerous multi-stakeholders. Thus, the objective of the present review is to evaluate whether NP species are important as “Future Food” for improving the nutritional status of humans as well as increasing resilience of agro- and horti-food systems.
KW  - Fruits
KW  - malnutrition
KW  - orphan crops
KW  - underutilized species
KW  - vegetables
Y1  - 2016
U6  - https://doi.org/10.1080/07352689.2016.1201399
SN  - 0735-2689
SN  - 1549-7836
VL  - 35
SP  - 106
EP  - 119
PB  - Institut d'Estudis Catalans
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Bandau, Anja
T1  - Pérez-Torres, R., Movements in Chicano poetry, against myths, against margins; Cambridge, Univ. Press, 1995
BT  - Movements in Chicano poetry : against myths, against margins
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Bandrauk, Andre D.
A1  - Paramonov, Guennaddi K.
T1  - Excitation of muonic molecules dd mu and dt mu by super-intense attosecond soft X-ray laser pulses: Shaped post-laser-pulse muonic oscillations and enhancement of nuclear fusion
JF  - International journal of modern physics : E, Nuclear physics
N2  - The quantum dynamics of muonic molecular ions dd mu and dt mu excited by linearly polarized along the molecular (z)-axis super-intense laser pulses is studied beyond the Born-Oppenheimer approximation by the numerical solution of the time-dependent Schrodinger equation within a three-dimensional model, including the internuclear distance R and muon coordinates z and rho. The peak-intensity of the super-intense laser pulses used in our simulations is I-0 = 3.51 x 10(22) W/cm(2) and the wavelength is lambda(l) = 5nm. In both dd mu and dt mu, expectation values < z > and <rho > of muon demonstrate "post-laser-pulse" oscillations after the ends of the laser pulses. In dd mu post-laser-pulse z-oscillations appear as shaped nonoverlapping "echo-pulses". In dt mu post-laser-pulse muonic z-oscillations appear as comparatively slow large-amplitude oscillations modulated with small-amplitude pulsations. The post-laser-pulse rho-oscillations in both dd mu and dt mu appear, for the most part, as overlapping "echo-pulses". The post-laser-pulse oscillations do not occur if the Born-Oppenheimer approximation is employed. Power spectra generated due to muonic motion along both optically active z and optically passive rho degrees of freedom are calculated. The fusion probability in dt mu can be increased by more than 11 times by making use of three sequential super-intense laser pulses. The energy released from the dt fusion in dt mu can by more than 20 GeV exceed the energy required to produce a usable muon and the energy of the laser pulses used to enhance the fusion. The possibility of power production from the laser-enhanced muon-catalyzed fusion is discussed.
KW  - Muonic molecules
KW  - super-intense laser pulses
KW  - laser-enhanced nuclear fusion
Y1  - 2014
U6  - https://doi.org/10.1142/S0218301314300148
SN  - 0218-3013
SN  - 1793-6608
VL  - 23
IS  - 9
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Barbolini, Natasha
A1  - Woutersen, Amber
A1  - Dupont-Nivet, Guillaume
A1  - Silvestro, Daniele
A1  - Tardif-Becquet, Delphine
A1  - Coster, Pauline M. C.
A1  - Meijer, Niels
A1  - Chang, Cun
A1  - Zhang, Hou-Xi
A1  - Licht, Alexis
A1  - Rydin, Catarina
A1  - Koutsodendris, Andreas
A1  - Han, Fang
A1  - Rohrmann, Alexander
A1  - Liu, Xiang-Jun
A1  - Zhang, Y.
A1  - Donnadieu, Yannick
A1  - Fluteau, Frederic
A1  - Ladant, Jean-Baptiste
A1  - Le Hir, Guillaume
A1  - Hoorn, M. Carina
T1  - Cenozoic evolution of the steppe-desert biome in Central Asia
JF  - Science Advances
N2  - The origins and development of the arid and highly seasonal steppe-desert biome in Central Asia, the largest of its kind in the world, remain largely unconstrained by existing records. It is unclear how Cenozoic climatic, geological, and biological forces, acting at diverse spatial and temporal scales, shaped Central Asian ecosystems through time. Our synthesis shows that the Central Asian steppe-desert has existed since at least Eocene times but experienced no less than two regime shifts, one at the Eocene-Oligocene Transition and one in the mid-Miocene. These shifts separated three successive "stable states," each characterized by unique floral and faunal structures. Past responses to disturbance in the Asian steppe-desert imply that modern ecosystems are unlikely to recover their present structures and diversity if forced into a new regime. This is of concern for Asian steppes today, which are being modified for human use and lost to desertification at unprecedented rates.
Y1  - 2020
U6  - https://doi.org/10.1126/sciadv.abb8227
SN  - 2375-2548
VL  - 6
IS  - 41
PB  - American Association for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Basler, Georg
A1  - Fernie, Alisdair R.
A1  - Nikoloski, Zoran
T1  - Advances in metabolic flux analysis toward genome-scale profiling of higher organisms
JF  - Bioscience reports : communications and reviews in molecular and cellular biology
N2  - Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies.
Y1  - 2018
U6  - https://doi.org/10.1042/BSR20170224
SN  - 0144-8463
SN  - 1573-4935
VL  - 38
PB  - Portland Press (London)
CY  - London
ER  - 
TY  - JOUR
A1  - Baumann, Otto
A1  - Walz, Bernd
T1  - The blowfly salivary gland - A model system for analyzing the regulation of plasma membrane V-ATPase
JF  - Journal of insect physiology
N2  - Vacuolar H+-ATPases (V-ATPases) are heteromultimeric proteins that use the energy of ATP hydrolysis for the electrogenic transport of protons across membranes. They are common to all eukaryotic cells and are located in the plasma membrane or in membranes of acid organelles. In many insect epithelia, V-ATPase molecules reside in large numbers in the apical plasma membrane and create an electrochemical proton gradient that is used for the acidification or alkalinization of the extracellular space, the secretion or reabsorption of ions and fluids, the import of nutrients, and diverse other cellular activities. Here, we summarize our results on the functions and regulation of V-ATPase in the tubular salivary gland of the blowfly Calliphora vicina. In this gland, V-ATPase activity energizes the secretion of a KCl-rich saliva in response to the neurohormone serotonin (5-HT). Because of particular morphological and physiological features, the blowfly salivary glands are a superior and exemplary system for the analysis of the intracellular signaling pathways and mechanisms that modulate V-ATPase activity and solute transport in an insect epithelium.
KW  - Vacuolar-type H+-ATPase
KW  - Insect epithelia
KW  - Reversible assembly
KW  - cAMP
KW  - Phosphorylation
KW  - Calliphora vicina
Y1  - 2012
U6  - https://doi.org/10.1016/j.jinsphys.2011.11.015
SN  - 0022-1910
VL  - 58
IS  - 4
SP  - 450
EP  - 458
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Becher, Matthias A.
A1  - Osborne, Juliet L.
A1  - Thorbek, Pernille
A1  - Kennedy, Peter J.
A1  - Grimm, Volker
T1  - Towards a systems approach for understanding honeybee decline - a stocktaking and synthesis of existing models
JF  - Journal of applied ecology : an official journal of the British Ecological Society
N2  - 1. The health of managed and wild honeybee colonies appears to have declined substantially in Europe and the United States over the last decade. Sustainability of honeybee colonies is important not only for honey production, but also for pollination of crops and wild plants alongside other insect pollinators. A combination of causal factors, including parasites, pathogens, land use changes and pesticide usage, are cited as responsible for the increased colony mortality. 2. However, despite detailed knowledge of the behaviour of honeybees and their colonies, there are no suitable tools to explore the resilience mechanisms of this complex system under stress. Empirically testing all combinations of stressors in a systematic fashion is not feasible. We therefore suggest a cross-level systems approach, based on mechanistic modelling, to investigate the impacts of (and interactions between) colony and land management. 3. We review existing honeybee models that are relevant to examining the effects of different stressors on colony growth and survival. Most of these models describe honeybee colony dynamics, foraging behaviour or honeybee - varroa mite - virus interactions. 4. We found that many, but not all, processes within honeybee colonies, epidemiology and foraging are well understood and described in the models, but there is no model that couples in-hive dynamics and pathology with foraging dynamics in realistic landscapes. 5. Synthesis and applications. We describe how a new integrated model could be built to simulate multifactorial impacts on the honeybee colony system, using building blocks from the reviewed models. The development of such a tool would not only highlight empirical research priorities but also provide an important forecasting tool for policy makers and beekeepers, and we list examples of relevant applications to bee disease and landscape management decisions.
KW  - Apis mellifera
KW  - colony decline
KW  - feedbacks
KW  - integrated model
KW  - multiple stressors
KW  - predictive systems ecology
KW  - review
Y1  - 2013
U6  - https://doi.org/10.1111/1365-2664.12112
SN  - 0021-8901
VL  - 50
IS  - 4
SP  - 868
EP  - 880
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Beck, Christian
ED  - Ambühl, Annemarie
ED  - Carlà-Uhink, Filippo
ED  - Rollinger, Christian
ED  - Walde, Christine
T1  - Review of Hamish Williams: Tolkien and the Classical World
BT  - Walking Tree Publishers (Zurich/Jena 2021) (= Cormarë Series No. 45), 414 pp . ISBN: 978-3-905703-45-0, 44 €
JF  - thersites 15
Y1  - 2022
U6  - https://doi.org/10.34679/thersites.vol15.230
SN  - 2364-7612
VL  - 2022
IS  - 15
SP  - 314
EP  - 320
ER  - 
TY  - JOUR
A1  - Beck, Jan
A1  - Ballesteros-Mejia, Liliana
A1  - Buchmann, Carsten M.
A1  - Dengler, Jürgen
A1  - Fritz, Susanne A.
A1  - Gruber, Bernd
A1  - Hof, Christian
A1  - Jansen, Florian
A1  - Knapp, Sonja
A1  - Kreft, Holger
A1  - Schneider, Anne-Kathrin
A1  - Winter, Marten
A1  - Dormann, Carsten F.
T1  - What's on the horizon for macroecology?
JF  - Ecography : pattern and diversity in ecology ; research papers forum
N2  - Over the last two decades, macroecology the analysis of large-scale, multi-species ecological patterns and processes has established itself as a major line of biological research. Analyses of statistical links between environmental variables and biotic responses have long and successfully been employed as a main approach, but new developments are due to be utilized. Scanning the horizon of macroecology, we identified four challenges that will probably play a major role in the future. We support our claims by examples and bibliographic analyses. 1) Integrating the past into macroecological analyses, e.g. by using paleontological or phylogenetic information or by applying methods from historical biogeography, will sharpen our understanding of the underlying reasons for contemporary patterns. 2) Explicit consideration of the local processes that lead to the observed larger-scale patterns is necessary to understand the fine-grain variability found in nature, and will enable better prediction of future patterns (e.g. under environmental change conditions). 3) Macroecology is dependent on large-scale, high quality data from a broad spectrum of taxa and regions. More available data sources need to be tapped and new, small-grain large-extent data need to be collected. 4) Although macroecology already lead to mainstreaming cutting-edge statistical analysis techniques, we find that more sophisticated methods are needed to account for the biases inherent to sampling at large scale. Bayesian methods may be particularly suitable to address these challenges. To continue the vigorous development of the macroecological research agenda, it is time to address these challenges and to avoid becoming too complacent with current achievements.
Y1  - 2012
U6  - https://doi.org/10.1111/j.1600-0587.2012.07364.x
SN  - 0906-7590
SN  - 1600-0587
VL  - 35
IS  - 8
SP  - 673
EP  - 683
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Becker, Christian
A1  - Schenkel, Alexander
A1  - Szabo, Richard J.
T1  - Differential cohomology and locally covariant quantum field theory
JF  - Reviews in Mathematical Physics
N2  - We study differential cohomology on categories of globally hyperbolic Lorentzian manifolds. The Lorentzian metric allows us to define a natural transformation whose kernel generalizes Maxwell's equations and fits into a restriction of the fundamental exact sequences of differential cohomology. We consider smooth Pontryagin duals of differential cohomology groups, which are subgroups of the character groups. We prove that these groups fit into smooth duals of the fundamental exact sequences of differential cohomology and equip them with a natural presymplectic structure derived from a generalized Maxwell Lagrangian. The resulting presymplectic Abelian groups are quantized using the CCR-functor, which yields a covariant functor from our categories of globally hyperbolic Lorentzian manifolds to the category of C∗-algebras. We prove that this functor satisfies the causality and time-slice axioms of locally covariant quantum field theory, but that it violates the locality axiom. We show that this violation is precisely due to the fact that our functor has topological subfunctors describing the Pontryagin duals of certain singular cohomology groups. As a byproduct, we develop a Fréchet–Lie group structure on differential cohomology groups.
KW  - Algebraic quantum field theory
KW  - generalized Abelian gauge theory
KW  - differential cohomology
Y1  - 2017
U6  - https://doi.org/10.1142/S0129055X17500039
SN  - 0129-055X
SN  - 1793-6659
VL  - 29
IS  - 1
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Becker, Katrin Anne
A1  - Riethmueller, Joachim
A1  - Seitz, Aaron P.
A1  - Gardner, Aaron
A1  - Boudreau, Ryan
A1  - Kamler, Markus
A1  - Kleuser, Burkhard
A1  - Schuchman, Edward
A1  - Caldwell, Charles C.
A1  - Edwards, Michael J.
A1  - Grassme, Heike
A1  - Brodlie, Malcolm
A1  - Gulbins, Erich
T1  - Sphingolipids as targets for inhalation treatment of cystic fibrosis
JF  - Advanced drug delivery reviews
N2  - Studies over the past several years have demonstrated the important role of sphingolipids in cystic fibrosis (CF), chronic obstructive pulmonary disease and acute lung injury. Ceramide is increased in airway epithelial cells and alveolar macrophages of CF mice and humans, while sphingosine is dramatically decreased. This increase in ceramide results in chronic inflammation, increased death of epithelial cells, release of DNA into the bronchial lumen and thereby an impairment of mucociliary clearance; while the lack of sphingosine in airway epithelial cells causes high infection susceptibility in CF mice and possibly patients. The increase in ceramide mediates an ectopic expression of beta 1-integrins in the luminal membrane of CF epithelial cells, which results, via an unknown mechanism, in a down-regulation of acid ceramidase. It is predominantly this down-regulation of acid ceramidase that results in the imbalance of ceramide and sphingosine in CF cells. Correction of ceramide and sphingosine levels can be achieved by inhalation of functional acid sphingomyelinase inhibitors, recombinant acid ceramidase or by normalization of beta 1-integrin expression and subsequent re-expression of endogenous acid ceramidase. These treatments correct pulmonary inflammation and prevent or treat, respectively, acute and chronic pulmonary infections in CF mice with Staphylococcus aureus and mucoid or non-mucoid Pseudomonas aeruginosa. Inhalation of sphingosine corrects sphingosine levels only and seems to mainly act against the infection. Many antidepressants are functional inhibitors of the acid sphingomyelinase and were designed for systemic treatment of major depression. These drugs could be repurposed to treat CF by inhalation.
KW  - Ceramide
KW  - Acid sphingomyelinase
KW  - Cystic fibrosis
KW  - COPD
KW  - Inhalation
Y1  - 2018
U6  - https://doi.org/10.1016/j.addr.2018.04.015
SN  - 0169-409X
SN  - 1872-8294
VL  - 133
SP  - 66
EP  - 75
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Behm, David George
A1  - Young, James D.
A1  - Whitten, Joseph H. D.
A1  - Reid, Jonathan C.
A1  - Quigley, Patrick J.
A1  - Low, Jonathan
A1  - Li, Yimeng
A1  - Lima, Camila D.
A1  - Hodgson, Daniel D.
A1  - Chaouachi, Anis
A1  - Prieske, Olaf
A1  - Granacher, Urs
T1  - Effectiveness of Traditional Strength vs. Power Training on Muscle Strength, Power and Speed with Youth: A Systematic Review and Meta-Analysis
JF  - Frontiers in physiology
N2  - Numerous national associations and multiple reviews have documented the safety and efficacy of strength training for children and adolescents. The literature highlights the significant training-induced increases in strength associated with youth strength training. However, the effectiveness of youth strength training programs to improve power measures is not as clear. This discrepancy may be related to training and testing specificity. Most prior youth strength training programs emphasized lower intensity resistance with relatively slow movements. Since power activities typically involve higher intensity, explosive-like contractions with higher angular velocities (e.g., plyometrics), there is a conflict between the training medium and testing measures. This meta-analysis compared strength (e.g., training with resistance or body mass) and power training programs (e.g., plyometric training) on proxies of muscle strength, power, and speed. A systematic literature search using a Boolean Search Strategy was conducted in the electronic databases PubMed, SPORT Discus, Web of Science, and Google Scholar and revealed 652 hits. After perusal of title, abstract, and full text, 107 studies were eligible for inclusion in this systematic review and meta-analysis. The meta-analysis showed small to moderate magnitude changes for training specificity with jump measures. In other words, power training was more effective than strength training for improving youth jump height. For sprint measures, strength training was more effective than power training with youth. Furthermore, strength training exhibited consistently large magnitude changes to lower body strength measures, which contrasted with the generally trivial, small and moderate magnitude training improvements of power training upon lower body strength, sprint and jump measures, respectively. Maturity related inadequacies in eccentric strength and balance might influence the lack of training specificity with the unilateral landings and propulsions associated with sprinting. Based on this meta-analysis, strength training should be incorporated prior to power training in order to establish an adequate foundation of strength for power training activities.
KW  - children
KW  - boys
KW  - girls
KW  - plyometric training
KW  - resistance training
Y1  - 2017
U6  - https://doi.org/10.3389/fphys.2017.00423
SN  - 1664-042X
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Beijersbergen, Chantal M. I.
A1  - Granacher, Urs
A1  - Vandervoort, A. A.
A1  - DeVita, P.
A1  - Hortobagyi, Tibor
T1  - The biomechanical mechanism of how strength and power training improves walking speed in old adults remains unknown
JF  - Ageing research reviews : ARR
N2  - Maintaining and increasing walking speed in old age is clinically important because this activity of daily living predicts functional and clinical state. We reviewed evidence for the biomechanical mechanisms of how strength and power training increase gait speed in old adults. A systematic search yielded only four studies that reported changes in selected gait biomechanical variables after an intervention. A secondary analysis of 20 studies revealed an association of r(2) = 0.21 between the 22% and 12% increase, respectively, in quadriceps strength and gait velocity in 815 individuals age 72. In 6 studies, there was a correlation of r(2) = 0.16 between the 19% and 9% gains in plantarflexion strength and gait speed in 240 old volunteers age 75. In 8 studies, there was zero association between the 35% and 13% gains in leg mechanical power and gait speed in 150 old adults age 73. To increase the efficacy of intervention studies designed to improve gait speed and other critical mobility functions in old adults, there is a need for a paradigm shift from conventional (clinical) outcome assessments to more sophisticated biomechanical analyses that examine joint kinematics, kinetics, energetics, muscle-tendon function, and musculoskeletal modeling before and after interventions.
KW  - Aging
KW  - Strength training
KW  - Power training
KW  - Gait biomechanics
Y1  - 2013
U6  - https://doi.org/10.1016/j.arr.2013.03.001
SN  - 1568-1637
VL  - 12
IS  - 2
SP  - 618
EP  - 627
PB  - Elsevier
CY  - Clare
ER  - 
TY  - JOUR
A1  - Beisner, Beatrix E.
A1  - Grossart, Hans-Peter
A1  - Gasol, Josep M.
T1  - A guide to methods for estimating phago-mixotrophy in nanophytoplankton
JF  - Journal of plankton research
N2  - Growing attention to phytoplankton mixotrophy as a trophic strategy has led to significant revisions of traditional pelagic food web models and ecosystem functioning. Although some empirical estimates of mixotrophy do exist, a much broader set of in situ measurements are required to (i) identify which organisms are acting as mixotrophs in real time and to (ii) assess the contribution of their heterotrophy to biogeochemical cycling. Estimates are needed through time and across space to evaluate which environmental conditions or habitats favour mixotrophy: conditions still largely unknown. We review methodologies currently available to plankton ecologists to undertake estimates of plankton mixotrophy, in particular nanophytoplankton phago-mixotrophy. Methods are based largely on fluorescent or isotopic tracers, but also take advantage of genomics to identify phylotypes and function. We also suggest novel methods on the cusp of use for phago-mixotrophy assessment, including single-cell measurements improving our capacity to estimate mixotrophic activity and rates in wild plankton communities down to the single-cell level. Future methods will benefit from advances in nanotechnology, micromanipulation and microscopy combined with stable isotope and genomic methodologies. Improved estimates of mixotrophy will enable more reliable models to predict changes in food web structure and biogeochemical flows in a rapidly changing world.
KW  - flow cytometry
KW  - phagotrophy
KW  - phytoplankton
KW  - methods
KW  - fluorescence
KW  - microscopy
KW  - FISH
KW  - isotopic methods
KW  - phylotypes
KW  - carbon flows
KW  - gene sequencing
Y1  - 2019
U6  - https://doi.org/10.1093/plankt/fbz008
SN  - 0142-7873
SN  - 1464-3774
VL  - 41
IS  - 2
SP  - 77
EP  - 89
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Bell, Elanor M.
A1  - Vincent, Amanda C. J.
T1  - Art.: Gasterosteiform
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Benina, Maria
A1  - Ribeiro, Dimas Mendes
A1  - Gechev, Tsanko S.
A1  - Müller-Röber, Bernd
A1  - Schippers, Jos H. M.
T1  - A cell type-specific view on the translation of mRNAs from ROS-responsive genes upon paraquat treatment of Arabidopsis thaliana leaves
JF  - Plant, cell & environment : cell physiology, whole-plant physiology, community physiology
N2  - Oxidative stress causes dramatic changes in the expression levels of many genes. The formation of a functional protein through successful mRNA translation is central to a coordinated cellular response. To what extent the response towards reactive oxygen species (ROS) is regulated at the translational level is poorly understood. Here we analysed leaf- and tissue-specific translatomes using a set of transgenic Arabidopsis thaliana lines expressing a FLAG-tagged ribosomal protein to immunopurify polysome-bound mRNAs before and after oxidative stress. We determined transcript levels of 171 ROS-responsive genes upon paraquat treatment, which causes formation of superoxide radicals, at the whole-organ level. Furthermore, the translation of mRNAs was determined for five cell types: mesophyll, bundle sheath, phloem companion, epidermal and guard cells. Mesophyll and bundle sheath cells showed the strongest response to paraquat treatment. Interestingly, several ROS-responsive transcription factors displayed cell type-specific translation patterns, while others were translated in all cell types. In part, cell type-specific translation could be explained by the length of the 5-untranslated region (5-UTR) and the presence of upstream open reading frames (uORFs). Our analysis reveals insights into the translational regulation of ROS-responsive genes, which is important to understanding cell-specific responses and functions during oxidative stress.
 The study illustrates the response of different Arabidopsis thaliana leaf cells and tissues to oxidative stress at the translational level, an aspect of reactive oxygen species (ROS) biology that has been little studied in the past. Our data reveal insights into how translational regulation of ROS-responsive genes is fine-tuned at the cellular level, a phenomenon contributing to the integrated physiological response of leaves to stresses involving changes in ROS levels.
KW  - Arabidopsis
KW  - gene regulation
KW  - oxidative stress
KW  - tissue-specific
KW  - translation
Y1  - 2015
U6  - https://doi.org/10.1111/pce.12355
SN  - 0140-7791
SN  - 1365-3040
VL  - 38
IS  - 2
SP  - 349
EP  - 363
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Bernhardt, Anne
A1  - Melnick, Daniel
A1  - Hebbeln, Dierk
A1  - Lückge, Andreas
A1  - Strecker, Manfred
T1  - Turbidite paleoseismology along the active continental margin of Chile - Feasible or not?
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
N2  - Much progress has been made in estimating recurrence intervals of great and giant subduction earthquakes using terrestrial, lacustrine, and marine paleoseismic archives. Recent detailed records suggest these earthquakes may have variable recurrence periods and magnitudes forming supercycles. Understanding seismic supercycles requires long paleoseismic archives that record timing and magnitude of such events. Turbidite paleoseismic archives may potentially extend past earthquake records to the Pleistocene and can thus complement commonly shorter-term terrestrial archives. However, in order to unambiguously establish recurring seismicity as a trigger mechanism for turbidity currents, synchronous deposition of turbidites in widely spaced, isolated depocenters has to be ascertained. Furthermore, characteristics that predispose a seismically active continental margin to turbidite paleoseismology and the correct sample site selection have to be taken into account.
 Here we analyze 8 marine sediment cores along 950 km of the Chile margin to test for the feasibility of compiling detailed and continuous paleoseismic records based on turbidites. Our results suggest that the deposition of areally widespread, synchronous turbidites triggered by seismicity is largely controlled by sediment supply and, hence, the climatic and geomorphic conditions of the adjacent subaerial setting. The feasibility of compiling a turbidite paleoseismic record depends on the delicate balance between sufficient sediment supply providing material to fail frequently during seismic shaking and sufficiently low sedimentation rates to allow for coeval accumulation of planktonic foraminifera for high-resolution radiocarbon dating.
 We conclude that offshore northern central Chile (29-32.5 degrees S) Holocene turbidite paleoseismology is not feasible, because sediment supply from the semi-arid mainland is low and almost no Holocene turbidity-current deposits are found in the cores. In contrast, in the humid region between 36 and 38 degrees S frequent Holocene turbidite deposition may generally correspond to paleoseismic events. However, high terrigenous sedimentation rates prevent high-resolution radiocarbon dating. The climatic transition region between 32.5 and 36 degrees S appears to be best suited for turbidite paleoseismology. (C) 2015 Elsevier Ltd. All rights reserved.
KW  - Turbidite paleoseismology
KW  - Chile convergent margin
KW  - Earthquake
KW  - Seismoturbidites
Y1  - 2015
U6  - https://doi.org/10.1016/j.quascirev.2015.04.001
SN  - 0277-3791
VL  - 120
SP  - 71
EP  - 92
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Bertilsson, Stefan
A1  - Burgin, Amy
A1  - Carey, Cayelan C.
A1  - Fey, Samuel B.
A1  - Grossart, Hans-Peter
A1  - Grubisic, Lorena M.
A1  - Jones, Ian D.
A1  - Kirillin, Georgiy
A1  - Lennon, Jay T.
A1  - Shade, Ashley
A1  - Smyth, Robyn L.
T1  - The under-ice microbiome of seasonally frozen lakes
JF  - Limnology and oceanography
N2  - Compared to the well-studied open water of the "growing" season, under-ice conditions in lakes are characterized by low and rather constant temperature, slow water movements, limited light availability, and reduced exchange with the surrounding landscape. These conditions interact with ice-cover duration to shape microbial processes in temperate lakes and ultimately influence the phenology of community and ecosystem processes. We review the current knowledge on microorganisms in seasonally frozen lakes. Specifically, we highlight how under-ice conditions alter lake physics and the ways that this can affect the distribution and metabolism of auto-and heterotrophic microorganisms. We identify functional traits that we hypothesize are important for understanding under-ice dynamics and discuss how these traits influence species interactions. As ice coverage duration has already been seen to reduce as air temperatures have warmed, the dynamics of the under-ice microbiome are important for understanding and predicting the dynamics and functioning of seasonally frozen lakes in the near future.
Y1  - 2013
U6  - https://doi.org/10.4319/lo.2013.58.6.1998
SN  - 0024-3590
SN  - 1939-5590
VL  - 58
IS  - 6
SP  - 1998
EP  - 2012
PB  - Wiley
CY  - Waco
ER  - 
TY  - JOUR
A1  - Beta, Carsten
A1  - Bodenschatz, Eberhard
T1  - Microfluidic tools for quantitative studies of eukaryotic chemotaxis
JF  - European journal of cell biology
N2  - Over the past decade, microfluidic techniques have been established as a versatile platform to perform live cell experiments under well-controlled conditions. To investigate the directional responses of cells, stable concentration profiles of chemotactic factors can be generated in microfluidic gradient mixers that provide a high degree of spatial control. However, the times for built-up and switching of gradient profiles are in general too slow to resolve the intracellular protein translocation events of directional sensing of eukaryotes. Here, we review an example of a conventional microfluidic gradient mixer as well as the novel flow photolysis technique that achieves an increased temporal resolution by combining the photo-activation of caged compounds with the advantages of microfluidic chambers.
KW  - Eukaryotic chemotaxis
KW  - Dictyostelium discoideum
KW  - Microfluidics
KW  - Caged compounds
KW  - Numerical simulations
Y1  - 2011
U6  - https://doi.org/10.1016/j.ejcb.2011.05.006
SN  - 0171-9335
VL  - 90
IS  - 10
SP  - 811
EP  - 816
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Bialas, Wolfgang
T1  - Rabinbach, Anson, In the shadow of catastrophe : German intellectuals between apocalypse and enlightenment; Berkeley [u.a.], Univ. of California Press, 1997
BT  - In the shadow of catastrophe : German intellectuals between apocalypse and enlightenment / Anson Rabinbach. - Berkeley [u.a.]: Univ. of California Press, 1997
Y1  - 1999
ER  - 
TY  - JOUR
A1  - Blaum, Niels
A1  - Mosner, Eva
A1  - Schwager, Monika
A1  - Jeltsch, Florian
T1  - How functional is functional?Ecological groupings in terrestrial animal ecology - towards an animal functional type approach
JF  - Biodiversity and conservation
N2  - Understanding mechanisms to predict changes in plant and animal communities is a key challenge in ecology. The need to transfer knowledge gained from single species to a more generalized approach has led to the development of categorization systems where species' similarities in life strategies and traits are classified into ecological groups (EGs) like functional groups/types or guilds. While approaches in plant ecology undergo a steady improvement and refinement of methodologies, progression in animal ecology is lagging behind. With this review, we aim to initiate a further development of functional classification systems in animal ecology, comparable to recent developments in plant ecology. We here (i) give an overview of terms and definitions of EGs in animal ecology, (ii) discuss existing classification systems, methods and application areas of EGs (focusing on terrestrial vertebrates), and (iii) provide a "roadmap towards an animal functional type approach" for improving the application of EGs and classifications in animal ecology. We found that an animal functional type approach requires: (i) the identification of core traits describing species' dependency on their habitat and life history traits, (ii) an optimization of trait selection by clustering traits into hierarchies, (iii) the assessment of "soft traits" as substitute for hardly measurable traits, e.g. body size for dispersal ability, and (iv) testing of delineated groups for validation including experiments.
KW  - Ecological classification
KW  - Functional type
KW  - Guild
KW  - Functional trait
KW  - Trait selection
KW  - Effect group
KW  - Response group
KW  - Environmental relationships
Y1  - 2011
U6  - https://doi.org/10.1007/s10531-011-9995-1
SN  - 0960-3115
VL  - 20
IS  - 11
SP  - 2333
EP  - 2345
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Bleek, Katrin
A1  - Taubert, Andreas
T1  - New developments in polymer-controlled, bioinspired calcium phosphate mineralization from aqueous solution
JF  - Acta biomaterialia
N2  - The polymer-controlled and bioinspired precipitation of inorganic minerals from aqueous solution at near-ambient or physiological conditions avoiding high temperatures or organic solvents is a key research area in materials science. Polymer-controlled mineralization has been studied as a model for biomineralization and for the synthesis of (bioinspired and biocompatible) hybrid materials for a virtually unlimited number of applications. Calcium phosphate mineralization is of particular interest for bone and dental repair. Numerous studies have therefore addressed the mineralization of calcium phosphate using a wide variety of low- and high-molecular-weight additives. In spite of the growing interest and increasing number of experimental and theoretical data, the mechanisms of polymer-controlled calcium phosphate mineralization are not entirely clear to date, although the field has made significant progress in the last years. A set of elegant experiments and calculations has shed light on some details of mineral formation, but it is currently not possible to preprogram a mineralization reaction to yield a desired product for a specific application. The current article therefore summarizes and discusses the influence of (macro)molecular entities such as polymers, peptides, proteins and gels on biomimetic calcium phosphate mineralization from aqueous solution. It focuses on strategies to tune the kinetics, morphologies, final dimensions and crystal phases of calcium phosphate, as well as on mechanistic considerations.
KW  - Calcium phosphate
KW  - Biomimetics
KW  - Mineralization
KW  - Polymers
KW  - Bioinspired
Y1  - 2013
U6  - https://doi.org/10.1016/j.actbio.2012.12.027
SN  - 1742-7061
SN  - 1878-7568
VL  - 9
IS  - 5
SP  - 6283
EP  - 6321
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Blell, Gabriele
T1  - Mitchell, M., Caribbean stories, I see these island; München, Langenscheidt-Longman, 1996
BT  - Caribbean stories : I see these island
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Blell, Gabriele
T1  - The postcolonial experience : decolonizing the mind ; Langenscheidt-Longman, München, 1995 (Viewfinder : Topics)
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Blell, Gabriele
T1  - Davis, A., Wells, S., Shakespeare and the moving image; Cambridge, Cambridge Univ. Press, 1994
BT  - Shakespeare and the moving image
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Blell, Gabriele
T1  - Freese, P. (Hrsg.), Growing up in a multicultural society, nine american short stories; München, Langenscheidt-Longman, 1994 (Viewfinder : Literature)
BT  - Growing up in a multicultural society : nine american short stories
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Blell, Gabriele
T1  - Freese, P., From melting pot to multiculturalism; München, Langenscheidt-Longman, 1994
BT  - From melting pot to multiculturalism
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Blenau, Wolfgang
A1  - Thamm, Markus
T1  - Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies lessons from Drosophila melanogaster and Apis mellifera
JF  - Arthropod structure & development
N2  - The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and modulating various physiological and behavioral processes in both protostomes and deuterostomes. The specific functions of serotonin are mediated by its binding to and subsequent activation of membrane receptors. The vast majority of these receptors belong to the superfamily of G-protein-coupled receptors. We report here the in vivo expression pattern of a recently characterized 5-HT(1) receptor of the honeybee Apis mellifera (Am5-HT(1A)) in the mushroom bodies. In addition, we summarize current knowledge on the distribution of serotonin and serotonin receptor subtypes in the brain and specifically in the mushroom bodies of the fruit fly Drosophila melanogaster and the honeybee. Functional studies in these two species have shown that serotonergic signaling participates in various behaviors including aggression, sleep, circadian rhythms, responses to visual stimuli, and associative learning. The molecular, pharmacological, and functional properties of identified 5-HT receptor subtypes from A. mellifera and D. melanogaster will also be summarized in this review.
KW  - Apis mellifera
KW  - G-protein-coupled receptor
KW  - Drosophila melanogaster
KW  - Mushroom body
KW  - Serotonin
Y1  - 2011
U6  - https://doi.org/10.1016/j.asd.2011.01.004
SN  - 1467-8039
VL  - 40
IS  - 5
SP  - 381
EP  - 394
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Block, Benjamin D.
A1  - Denfeld, Blaize A.
A1  - Stockwell, Jason D.
A1  - Flaim, Giovanna
A1  - Grossart, Hans-Peter
A1  - Knoll, Lesley B.
A1  - Maier, Dominique B.
A1  - North, Rebecca L.
A1  - Rautio, Milla
A1  - Rusak, James A.
A1  - Sadro, Steve
A1  - Weyhenmeyer, Gesa A.
A1  - Bramburger, Andrew J.
A1  - Branstrator, Donn K.
A1  - Salonen, Kalevi
A1  - Hampton, Stephanie E.
T1  - The unique methodological challenges of winter limnology
JF  - Limnology and Oceanography: Methods
N2  - Winter is an important season for many limnological processes, which can range from biogeochemical transformations to ecological interactions. Interest in the structure and function of lake ecosystems under ice is on the rise. Although limnologists working at polar latitudes have a long history of winter work, the required knowledge to successfully sample under winter conditions is not widely available and relatively few limnologists receive formal training. In particular, the deployment and operation of equipment in below 0 degrees C temperatures pose considerable logistical and methodological challenges, as do the safety risks of sampling during the ice-covered period. Here, we consolidate information on winter lake sampling and describe effective methods to measure physical, chemical, and biological variables in and under ice. We describe variation in snow and ice conditions and discuss implications for sampling logistics and safety. We outline commonly encountered methodological challenges and make recommendations for best practices to maximize safety and efficiency when sampling through ice or deploying instruments in ice-covered lakes. Application of such practices over a broad range of ice-covered lakes will contribute to a better understanding of the factors that regulate lakes during winter and how winter conditions affect the subsequent ice-free period.
Y1  - 2018
U6  - https://doi.org/10.1002/lom3.10295
SN  - 1541-5856
VL  - 17
IS  - 1
SP  - 42
EP  - 57
PB  - Wiley
CY  - Hoboken
ER  -