TY - GEN A1 - Hocher, Berthold A1 - Tsuprykov, Oleg T1 - Renoprotective effects of GLP1R agonists and SGLT2 inhibitors T2 - Nature reviews nephroloy N2 - New data from the LEADER trial show that the glucagon-like peptide 1 receptor agonist liraglutide protects against diabetic nephropathy in patients with type 2 diabetes mellitus. The renoprotective efficacy of liraglutide is not, however, as great as that reported for the sodium-glucose cotransporter 2 inhibitor emplagiflozin in the EMPA-REG OUTCOME trial. Y1 - 2017 U6 - https://doi.org/10.1038/nrneph.2017.140 SN - 1759-5061 SN - 1759-507X VL - 13 SP - 728 EP - 729 PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Huck, Stefan A1 - Wohlwend, Stephan A1 - Coimbra, Rute A1 - Christ, Nicolas A1 - Weissert, Helmut T1 - Disentangling shallow-water bulk carbonate carbon isotope archives with evidence for multi-stage diagenesis BT - an in-depth component-specific petrographic and geochemical study from Oman (mid-Cretaceous) JF - The depositional record N2 - Disentangling shallow‐water bulk carbonate carbon isotope archives into primary and diagenetic components is a notoriously difficult task and even diagenetically screened records often provide chemostratigraphic patterns that significantly differ from global signals. This is mainly caused by the polygenetic nature of shallow‐water carbonate substrates, local carbon cycle processes causing considerable neritic–pelagic isotope gradients and the presence of hiatal surfaces resulting in extremely low carbonate preservation rates. Provided here is an in‐depth petrographic and geochemical evaluation of different carbonate phases of a mid‐Cretaceous (Barremian–Aptian) shallow‐water limestone succession (Jabal Madar section) deposited on the tropical Arabian carbonate platform in Oman. The superposition of stable isotope signatures of identified carbonate phases causes a complex and often noisy bulk carbon isotope pattern. Blocky sparite cements filling intergranular pores and bioclastic voids evidence intermediate to (arguably) deep burial diagenetic conditions during their formation, owing to different timing or differential faulting promoting the circulation of fluids from variable sources. In contrast, sparite cements filling sub‐vertical veins reveal a rock‐buffered diagenetic fluid composition with an intriguing moderate enrichment in 13C, probably due to fractionation during pressure release in the context of the Miocene exhumation of the carbonate platform under study. The presence of abundant, replacive dedolomite in mud‐supported limestone samples forced negative carbon and oxygen isotope changes that are either associated with the thermal breakdown of organic matter in the deep burial realm or the expulsion of buried meteoric water in the intermediate burial realm. Notwithstanding the documented stratigraphically variable and often facies‐related impact of different diagenetic fluids on the bulk‐rock stable isotope signature, the identification of diagenetic end‐members defined δ13C and δ18O threshold values that allowed the most reliable ‘primary’ bulk carbon isotope signatures to be extracted. Most importantly, this approach exemplifies how to place regional shallow‐water stable isotope patterns with evidence for a complex multi‐stage diagenetic history into a supraregional or even global context. KW - Arabian carbonate platform KW - Barremian-Aptian KW - multi-stage diagenesis KW - shallow-water chemostratigraphy Y1 - 2017 U6 - https://doi.org/10.1002/dep2.35 SN - 2055-4877 VL - 3 SP - 233 EP - 257 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Stange, Maike A1 - Hintsche, Marius A1 - Sachse, Kirsten A1 - Gerhardt, Matthias A1 - Valleriani, Angelo A1 - Beta, Carsten T1 - Analyzing the spatial positioning of nuclei in polynuclear giant cells JF - Journal of Physics D: Applied Physics N2 - How cells establish and maintain a well-defined size is a fundamental question of cell biology. Here we investigated to what extent the microtubule cytoskeleton can set a predefined cell size, independent of an enclosing cell membrane. We used electropulse-induced cell fusion to form giant multinuclear cells of the social amoeba Dictyostelium discoideum. Based on dual-color confocal imaging of cells that expressed fluorescent markers for the cell nucleus and the microtubules, we determined the subcellular distributions of nuclei and centrosomes in the giant cells. Our two- and three-dimensional imaging results showed that the positions of nuclei in giant cells do not fall onto a regular lattice. However, a comparison with model predictions for random positioning showed that the subcellular arrangement of nuclei maintains a low but still detectable degree of ordering. This can be explained by the steric requirements of the microtubule cytoskeleton, as confirmed by the effect of a microtubule degrading drug. KW - Dictyostelium KW - cell nucleus KW - positioning KW - imaging KW - spatial poisson distribution Y1 - 2017 U6 - https://doi.org/10.1088/1361-6463/aa8da0 SN - 0022-3727 SN - 1361-6463 VL - 50 IS - 46 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Das, Debopam A1 - Taboada, Maite T1 - Signalling of Coherence Relations in Discourse, Beyond Discourse Markers JF - Discourse processes : DP ; a multidisciplinary journal N2 - We argue that coherence relations (relations between propositions, such as Concession or Purpose) are signalled more frequently and by more means than is generally believed. We examine how coherence relations in text are indicated by all possible textual signals, and whether every relation is signalled. To that end, we conducted a corpus study on the RST Discourse Treebank, a corpus of newspaper articles annotated for rhetorical (or coherence) relations. Results from our corpus study show that most relations in text (over 90%) are signalled and also that most signalled relations (over 80%) are indicated not only by discourse markers (and, but, if, since), but also by a wide variety of signals other than discourse markers, such as reference, lexical, semantic, syntactic and graphical features. These findings suggest that signalling of coherence relations is much more sophisticated than previously thought. Y1 - 2017 U6 - https://doi.org/10.1080/0163853X.2017.1379327 SN - 0163-853X SN - 1532-6950 VL - 55 IS - 8 SP - 743 EP - 770 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Milewski, Robert A1 - Chabrillat, Sabine A1 - Behling, Robert T1 - Analyses of Recent Sediment Surface Dynamic of a Namibian Kalahari Salt Pan Based on Multitemporal Landsat and Hyperspectral Hyperion Data JF - Remote Sensing N2 - This study combines spaceborne multitemporal and hyperspectral data to analyze the spatial distribution of surface evaporite minerals and changes in a semi-arid depositional environment associated with episodic flooding events, the Omongwa salt pan (Kalahari, Namibia). The dynamic of the surface crust is evaluated by a change-detection approach using the Iterative-reweighted Multivariate Alteration Detection (IR-MAD) based on the Landsat archive imagery from 1984 to 2015. The results show that the salt pan is a highly dynamic and heterogeneous landform. A change gradient is observed from very stable pan border to a highly dynamic central pan. On the basis of hyperspectral EO-1 Hyperion images, the current distribution of surface evaporite minerals is characterized using Spectral Mixture Analysis (SMA). Assessment of field and image endmembers revealed that the pan surface can be categorized into three major crust types based on diagnostic absorption features and mineralogical ground truth data. The mineralogical crust types are related to different zones of surface change as well as pan morphology that influences brine flow during the pan inundation and desiccation cycles. These combined information are used to spatially map depositional environments where the more dynamic halite crust concentrates in lower areas although stable gypsum and calcite/sepiolite crusts appear in higher elevated areas. KW - salt pan KW - playa KW - hyperspectral KW - multitemporal KW - change detection KW - evaporite minerals Y1 - 2016 U6 - https://doi.org/10.3390/rs9020170 SN - 2072-4292 VL - 9 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Scholkmann, Antonia A1 - Siemon, Jens A1 - Boom, Kay-Dennis A1 - Knigge, Michel T1 - Lernzeitnutzung im Planspielunterricht BT - Eine Analyse des Einflusses kognitiver Fähigkeiten, Zielorientierungen und Charakteristika von Lernpartnern anhand von Videodaten JF - Zeitschrift für Erziehungswissenschaft N2 - The effective use of learning time is considered one of the most important predictors of successful and good teaching. In the present study we investigated how cognitive skills and goal orientation influenced the effective use of learning time during the open phases of game-based learning We used a newly developed method for video- and audio analysis (German: MuVA), which allowed for reliable documentation of students’ interactions during those phases. The two-step multiple regression model demonstrated that both the learner’s and the learning partner’s goal orientation explain significant parts of the variance: A high performance goal orientation impairs a student’s effective use of learning time, while a high performance avoidance orientation has a positive impact on his or her effective use of learning time. Working with a partner who has a high learning goal orientation or a high work avoidance orientation increases a student’s effective use of his or her learning time, while a high work avoidance orientation on the partner’s side has the opposite effect. Cognitive skills did not influence the effective use of learning time. N2 - Effektive Lernzeitnutzung gilt als einer der wichtigsten Prädiktoren für erfolgreichen Unterricht. Die vorliegende Studie untersucht in einem dyadischen kooperativen Lernsetting, wie sich die kognitiven Grundfähigkeiten und Zielorientierungen der Partner in den offenen Phasen eines Planspielunterrichts auf die effektive Lernzeitnutzung auswirken. Hierzu nutzten wir die neu entwickelte Multimodale Video- und Audioanalysemethode (MuVA), welche es ermöglicht, Schüler-Interaktionen in offenen Unterrichtsphasen reliabel zu dokumentieren. In zweischrittigen Regressionsmodellen ließ sich aufzeigen, dass sowohl Lernenden- als auch Partnervariablen signifikante Anteile der Varianz erklären: Bei Lernenden selbst beeinflusst eine hohe Leistungszielorientierung die effektive Lernzeitnutzung negativ und eine hohe Vermeidungs-Leistungszielorientierung positiv. Einflüsse durch die Eigenschaften der Lernpartner zeigten sich in positiver Richtung für hohe Ausprägungen der Lern-Zielorientierung und der Vermeidungs-Leistungszielorientierung sowie in negativer Richtung für eine hohe Arbeitsvermeidungsorientierung. Kognitive Grundfähigkeiten hatten keinen Einfluss auf die effektive Lernzeitnutzung. T2 - Time on task during game-based learning. The effects of cognitive skills, goal orientations and the characteristics of learning partners - an analysis based on video data KW - Cognitive skills KW - Effective learning time KW - Game-based learning KW - Goal orientation KW - Time on task KW - Video analysis KW - Videoanalyse KW - effektive Lernzeit KW - kognitive Grundfähigkeiten KW - Zielorientierung KW - Planspiel Y1 - 2017 U6 - https://doi.org/10.1007/s11618-017-0736-4 SN - 1434-663X SN - 1862-5215 VL - 20 SP - 651 EP - 669 PB - Springer CY - Wiesbaden ER - TY - JOUR A1 - Adani, Flavia A1 - Stegenwallner-Schutz, Maja Henny Katherine A1 - Niesel, Talea T1 - The Peaceful Co-existence of Input Frequency and Structural Intervention Effects on the Comprehension of Complex Sentences in German-Speaking Children JF - Frontiers in psychology N2 - The predictions of two contrasting approaches to the acquisition of transitive relative clauses were tested within the same groups of German-speaking participants aged from 3 to 5 years old. The input frequency approach predicts that object relative clauses with inanimate heads (e.g., the pullover that the man is scratching) are comprehended earlier and more accurately than those with an animate head (e.g., the man that the boy is scratching). In contrast, the structural intervention approach predicts that object relative clauses with two full NP arguments mismatching in number (e.g., the man that the boys are scratching) are comprehended earlier and more accurately than those with number-matching NPs (e.g., the man that the boy is scratching). These approaches were tested in two steps. First, we ran a corpus analysis to ensure that object relative clauses with number-mismatching NPs are not more frequent than object relative clauses with number-matching NPs in child directed speech. Next, the comprehension of these structures was tested experimentally in 3-, 4-, and 5-year-olds respectively by means of a color naming task. By comparing the predictions of the two approaches within the same participant groups, we were able to uncover that the effects predicted by the input frequency and by the structural intervention approaches co-exist and that they both influence the performance of children on transitive relative clauses, but in a manner that is modulated by age. These results reveal a sensitivity to animacy mismatch already being demonstrated by 3-year-olds and show that animacy is initially deployed more reliably than number to interpret relative clauses correctly. In all age groups, the animacy mismatch appears to explain the performance of children, thus, showing that the comprehension of frequent object relative clauses is enhanced compared to the other conditions. Starting with 4-year-olds but especially in 5-year-olds, the number mismatch supported comprehension-a facilitation that is unlikely to be driven by input frequency. Once children fine-tune their sensitivity to verb agreement information around the age of four, they are also able to deploy number marking to overcome the intervention effects. This study highlights the importance of testing experimentally contrasting theoretical approaches in order to characterize the multifaceted, developmental nature of language acquisition. KW - relative clauses KW - sentence comprehension KW - input frequency KW - number KW - animacy KW - language acquisition KW - German Y1 - 2017 U6 - https://doi.org/10.3389/fpsyg.2017.01590 SN - 1664-1078 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Wade, Jessica A1 - Wood, Sebastian A1 - Collado-Fregoso, Elisa A1 - Heeney, Martin A1 - Durrant, James A1 - Kim, Ji-Seon T1 - Impact of Fullerene Intercalation on Structural and Thermal Properties of Organic Photovoltaic Blends JF - The journal of physical chemistry : C, Nanomaterials and interfaces N2 - The performance of organic photovoltaic blend devices is critically dependent on the polymer:fullerene interface. These interfaces are expected to impact the structural and thermal properties of the polymer with regards to the conjugated backbone planarity and transition temperatures during annealing/cooling processes. Here, we report the impact of fullerene intercalation on structural and thermal properties of poly(2,5-bis(3-tetradecylthiophen-2-yOthieno[3,2-b]thiophene (PBTTT), a highly stable material known to exhibit liquid crystalline behavior. We undertake a detailed systematic study of the extent of intercalation in the PBTTT:fullerene blend, considering the use of four different fullerene derivatives and also varying the loading ratios. Resonant Raman spectroscopy allows morphology in situ during controlled heating and cooling. We find that small fullerene molecules readily intercalate into PBTTT crystallites, resulting in a planarization of the polymer backbone, but high fullerene loading ratios or larger fullerenes result in nonintercalated domains. During cooling from melt, nonintercalated blend films are found to return to their original morphology and reproduce all thermal transitions on cooling with minimal hysteresis. Intercalated blend films show significant hysteresis on cooling due to the crystallized fullerene attempting to reintercalate. The strongest hysteresis is for intercalated blend films with excess fullerene loading ratio, which form a distinct nanoribbon morphology and exhibit a reduced geminate recombination rate. These results reveal that careful consideration should be taken during device fabrication, as postdeposition thermal treatments significantly impact the charge generation and recombination dynamics. Y1 - 2017 U6 - https://doi.org/10.1021/acs.jpcc.7b05893 SN - 1932-7447 VL - 121 SP - 20976 EP - 20985 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Fer, Istem A1 - Tietjen, Britta A1 - Jeltsch, Florian A1 - Wolff, Christian Michael T1 - The influence of El Nino-Southern Oscillation regimes on eastern African vegetation and its future implications under the RCP8.5 warming scenario JF - Biogeosciences N2 - The El Nino-Southern Oscillation (ENSO) is the main driver of the interannual variability in eastern African rainfall, with a significant impact on vegetation and agriculture and dire consequences for food and social security. In this study, we identify and quantify the ENSO contribution to the eastern African rainfall variability to forecast future eastern African vegetation response to rainfall variability related to a predicted intensified ENSO. To differentiate the vegetation variability due to ENSO, we removed the ENSO signal from the climate data using empirical orthogonal teleconnection (EOT) analysis. Then, we simulated the ecosystem carbon and water fluxes under the historical climate without components related to ENSO teleconnections. We found ENSO-driven patterns in vegetation response and confirmed that EOT analysis can successfully produce coupled tropical Pacific sea surface temperature-eastern African rainfall teleconnection from observed datasets. We further simulated eastern African vegetation response under future climate change as it is projected by climate models and under future climate change combined with a predicted increased ENSO intensity. Our EOT analysis highlights that climate simulations are still not good at capturing rainfall variability due to ENSO, and as we show here the future vegetation would be different from what is simulated under these climate model outputs lacking accurate ENSO contribution. We simulated considerable differences in eastern African vegetation growth under the influence of an intensified ENSO regime which will bring further environmental stress to a region with a reduced capacity to adapt effects of global climate change and food security. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-4355-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 SP - 4355 EP - 4374 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Bössenkool, Berry A1 - Bürger, Gerd A1 - Heistermann, Maik T1 - Effects of sample size on estimation of rainfall extremes at high temperatures JF - Natural hazards and earth system sciences N2 - High precipitation quantiles tend to rise with temperature, following the so-called Clausius-Clapeyron (CC) scaling. It is often reported that the CC-scaling relation breaks down and even reverts for very high temperatures. In our study, we investigate this reversal using observational climate data from 142 stations across Germany. One of the suggested meteorological explanations for the breakdown is limited moisture supply. Here we argue that, instead, it could simply originate from undersampling. As rainfall frequency generally decreases with higher temperatures, rainfall intensities as dictated by CC scaling are less likely to be recorded than for moderate temperatures. Empirical quantiles are conventionally estimated from order statistics via various forms of plotting position formulas. They have in common that their largest representable return period is given by the sample size. In small samples, high quantiles are underestimated accordingly. The small-sample effect is weaker, or disappears completely, when using parametric quantile estimates from a generalized Pareto distribution (GPD) fitted with L moments. For those, we obtain quantiles of rainfall intensities that continue to rise with temperature. Y1 - 2017 U6 - https://doi.org/10.5194/nhess-17-1623-2017 SN - 1561-8633 VL - 17 SP - 1623 EP - 1629 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Knapmeyer-Endrun, Brigitte A1 - Golombek, Matthew P. A1 - Ohrnberger, Matthias T1 - Rayleigh Wave Ellipticity Modeling and Inversion for Shallow Structure at the Proposed InSight Landing Site in Elysium Planitia, Mars JF - Space science reviews N2 - The SEIS (Seismic Experiment for Interior Structure) instrument onboard the InSight mission will be the first seismometer directly deployed on the surface of Mars. From studies on the Earth and the Moon, it is well known that site amplification in low-velocity sediments on top of more competent rocks has a strong influence on seismic signals, but can also be used to constrain the subsurface structure. Here we simulate ambient vibration wavefields in a model of the shallow sub-surface at the InSight landing site in Elysium Planitia and demonstrate how the high-frequency Rayleigh wave ellipticity can be extracted from these data and inverted for shallow structure. We find that, depending on model parameters, higher mode ellipticity information can be extracted from single-station data, which significantly reduces uncertainties in inversion. Though the data are most sensitive to properties of the upper-most layer and show a strong trade-off between layer depth and velocity, it is possible to estimate the velocity and thickness of the sub-regolith layer by using reasonable constraints on regolith properties. Model parameters are best constrained if either higher mode data can be used or additional constraints on regolith properties from seismic analysis of the hammer strokes of InSight’s heat flow probe HP3 are available. In addition, the Rayleigh wave ellipticity can distinguish between models with a constant regolith velocity and models with a velocity increase in the regolith, information which is difficult to obtain otherwise. KW - Mars KW - Interior KW - Seismology KW - Regoliths Y1 - 2017 U6 - https://doi.org/10.1007/s11214-016-0300-1 SN - 0038-6308 SN - 1572-9672 VL - 211 SP - 339 EP - 382 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Benini, Marco A1 - Capoferri, Matteo A1 - Dappiaggi, Claudio T1 - Hadamard States for Quantum Abelian Duality JF - Annales de l'Institut Henri Poincaré N2 - Abelian duality is realized naturally by combining differential cohomology and locally covariant quantum field theory. This leads to a -algebra of observables, which encompasses the simultaneous discretization of both magnetic and electric fluxes. We discuss the assignment of physically well-behaved states on this algebra and the properties of the associated GNS triple. We show that the algebra of observables factorizes as a suitable tensor product of three -algebras: the first factor encodes dynamical information, while the other two capture topological data corresponding to electric and magnetic fluxes. On the former factor and in the case of ultra-static globally hyperbolic spacetimes with compact Cauchy surfaces, we exhibit a state whose two-point correlation function has the same singular structure of a Hadamard state. Specifying suitable counterparts also on the topological factors, we obtain a state for the full theory, ultimately implementing Abelian duality transformations as Hilbert space isomorphisms. Y1 - 2017 U6 - https://doi.org/10.1007/s00023-017-0593-y SN - 1424-0637 SN - 1424-0661 VL - 18 SP - 3325 EP - 3370 PB - Springer CY - Basel ER - TY - JOUR A1 - Goychuk, Igor T1 - Fractional Bhatnagar-Gross-Krook kinetic equation JF - The European physical journal : B, Condensed matter and complex systems N2 - The linear Boltzmann equation approach is generalized to describe fractional superdiffusive transport of the Levy walk type in external force fields. The time distribution between scattering events is assumed to have a finite mean value and infinite variance. It is completely characterized by the two scattering rates, one fractional and a normal one, which defines also the mean scattering rate. We formulate a general fractional linear Boltzmann equation approach and exemplify it with a particularly simple case of the Bohm and Gross scattering integral leading to a fractional generalization of the Bhatnagar, Gross and Krook kinetic equation. Here, at each scattering event the particle velocity is completely randomized and takes a value from equilibrium Maxwell distribution at a given fixed temperature. We show that the retardation effects are indispensable even in the limit of infinite mean scattering rate and argue that this novel fractional kinetic equation provides a viable alternative to the fractional Kramers-Fokker-Planck (KFP) equation by Barkai and Silbey and its generalization by Friedrich et al. based on the picture of divergent mean time between scattering events. The case of divergent mean time is also discussed at length and compared with the earlier results obtained within the fractional KFP. Also a phenomenological fractional BGK equation without retardation effects is proposed in the limit of infinite scattering rates. It cannot be, however, rigorously derived from a scattering model, being rather clever postulated. It this respect, this retardationless equation is similar to the fractional KFP by Barkai and Silbey. However, it corresponds to the opposite, much more physical limit and, therefore, also presents a viable alternative. Y1 - 2017 U6 - https://doi.org/10.1140/epjb/e2017-80297-x SN - 1434-6028 SN - 1434-6036 VL - 90 PB - Springer CY - New York ER - TY - JOUR A1 - Baumbach, Lukas A1 - Siegmund, Jonatan F. A1 - Mittermeier, Magdalena A1 - Donner, Reik Volker T1 - Impacts of temperature extremes on European vegetation during the growing season JF - Biogeosciences N2 - Temperature is a key factor controlling plant growth and vitality in the temperate climates of the mid-latitudes like in vast parts of the European continent. Beyond the effect of average conditions, the timings and magnitudes of temperature extremes play a particularly crucial role, which needs to be better understood in the context of projected future rises in the frequency and/or intensity of such events. In this work, we employ event coincidence analysis (ECA) to quantify the likelihood of simultaneous occurrences of extremes in daytime land surface temperature anomalies (LSTAD) and the normalized difference vegetation index (NDVI). We perform this analysis for entire Europe based upon remote sensing data, differentiating between three periods corresponding to different stages of plant development during the growing season. In addition, we analyze the typical elevation and land cover type of the regions showing significantly large event coincidences rates to identify the most severely affected vegetation types. Our results reveal distinct spatio-temporal impact patterns in terms of extraordinarily large co-occurrence rates between several combinations of temperature and NDVI extremes. Croplands are among the most frequently affected land cover types, while elevation is found to have only a minor effect on the spatial distribution of corresponding extreme weather impacts. These findings provide important insights into the vulnerability of European terrestrial ecosystems to extreme temperature events and demonstrate how event-based statistics like ECA can provide a valuable perspective on environmental nexuses. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-4891-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 SP - 4891 EP - 4903 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Majda, Mateusz A1 - Grones, Peter A1 - Sintorn, Ida-Maria A1 - Vain, Thomas A1 - Milani, Pascale A1 - Krupinski, Pawel A1 - Zagorska-Marek, Beata A1 - Viotti, Corrado A1 - Jonsson, Henrik A1 - Mellerowicz, Ewa J. A1 - Hamant, Olivier A1 - Robert, Stephanie T1 - Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells JF - Developmental cell N2 - The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local buckling events. Paradoxically, such local compressive buckling should not occur given the tensile stresses across the epidermis. Using computational modeling, we show that the simplest scenario to explain pavement cell shapes within an epidermis under tension must involve mechanical wall heterogeneities across and along the anticlinal pavement cell walls between adjacent cells. Combining genetics, atomic force microscopy, and immunolabeling, we demonstrate that contiguous cell walls indeed exhibit hybrid mechanochemical properties. Such biochemical wall heterogeneities precede wall bending. Altogether, this provides a possible mechanism for the generation of complex plant cell shapes. Y1 - 2017 U6 - https://doi.org/10.1016/j.devcel.2017.10.017 SN - 1534-5807 SN - 1878-1551 VL - 43 SP - 290 EP - + PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Kurze, Susanne A1 - Heinken, Thilo A1 - Fartmann, Thomas T1 - Nitrogen enrichment of host plants has mostly beneficial effects on the life-history traits of nettle-feeding butterflies JF - Acta oecologica : international journal of ecology N2 - Butterflies rank among the most threatened animal groups throughout Europe. However, current population trends differ among species. The nettle-feeding butterflies Aglais io and Aglais urticae cope successfully with the anthropogenic land-use change. Both species are assumed to be pre-adapted to higher nitrogen contents in their host plant, stinging nettle (Urtica dioica). However, it is currently unknown, whether this pre-adaptation enables both Aglais species to cope successfully or even to benefit from the excessive nitrogen availabilities in nettles growing in modern farmlands. For this reason, this study focused on the response of both Aglais species to unfertilized nettles compared to nettles receiving 150 or 300 kg N ha(-1) yr(-1) (i.e., common fertilizer quantities of modern-day agriculture). Fertilized nettles were characterized by higher nitrogen concentrations and lower C:N ratios compared to the control group. In both Aglais species, the individuals feeding on fertilized nettles had higher survival rates, shorter larval periods and heavier pupae and, in A. urticae also longer forewings. All these trait shifts are beneficial for the individuals, lowering their risk to die before reproduction and increasing their reproductive potential. These responses agree with the well-accepted nitrogen-limitation hypothesis predicting a positive relationship between the nitrogen content of the diet and the performance of herbivorous insects. Furthermore, our findings suggest that the increasing abundance of both Aglais species may result not only from the increasing spread of nettles into the farmland but also from changes in their quality due to the eutrophication of the landscape during recent decades. KW - Aglais KW - Fertilization KW - Host-plant quality KW - Landscape eutrophication KW - Nitrogen-limitation hypothesis KW - Rearing experiment Y1 - 2017 U6 - https://doi.org/10.1016/j.actao.2017.11.005 SN - 1146-609X SN - 1873-6238 VL - 85 SP - 157 EP - 164 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Delle Side, Domenico A1 - Nassisi, Vincenzo A1 - Pennetta, Cecilia A1 - Alifano, Pietro A1 - Di Salvo, Marco A1 - Tala, Adelfia A1 - Chechkin, Aleksei V. A1 - Seno, Flavio A1 - Trovato, Antonio T1 - Bacterial bioluminescence onset and quenching: a dynamical model for a quorum sensing-mediated property JF - Royal Society Open Science N2 - We present an effective dynamical model for the onset of bacterial bioluminescence, one of the most studied quorum sensing-mediated traits. Our model is built upon simple equations that describe the growth of the bacterial colony, the production and accumulation of autoinducer signal molecules, their sensing within bacterial cells, and the ensuing quorum activation mechanism that triggers bioluminescent emission. The model is directly tested to quantitatively reproduce the experimental distributions of photon emission times, previously measured for bacterial colonies of Vibrio jasicida, a luminescent bacterium belonging to the Harveyi clade, growing in a highly drying environment. A distinctive and novel feature of the proposed model is bioluminescence ‘quenching’ after a given time elapsed from activation. Using an advanced fitting procedure based on the simulated annealing algorithm, we are able to infer from the experimental observations the biochemical parameters used in the model. Such parameters are in good agreement with the literature data. As a further result, we find that, at least in our experimental conditions, light emission in bioluminescent bacteria appears to originate from a subtle balance between colony growth and quorum activation due to autoinducers diffusion, with the two phenomena occurring on the same time scale. This finding is consistent with a negative feedback mechanism previously reported for Vibrio harveyi. KW - quorum sensing KW - bioluminescence KW - biophysical model KW - Vibrio Harveyi clade KW - oxygen quenching KW - Gompertz growth function Y1 - 2017 U6 - https://doi.org/10.1098/rsos.171586 SN - 2054-5703 VL - 4 PB - Royal Society CY - London ER - TY - JOUR A1 - Dennis, Alice B. A1 - Patel, Vilas A1 - Oliver, Kerry M. A1 - Vorburger, Christoph T1 - Parasitoid gene expression changes after adaptation to symbiont-protected hosts JF - Evolution N2 - Reciprocal selection between aphids, their protective endosymbionts, and the parasitoid wasps that prey upon them offers an opportunity to study the basis of their coevolution. We investigated adaptation to symbiont‐conferred defense by rearing the parasitoid wasp Lysiphlebus fabarum on aphids (Aphis fabae) possessing different defensive symbiont strains (Hamiltonella defensa). After ten generations of experimental evolution, wasps showed increased abilities to parasitize aphids possessing the H. defensa strain they evolved with, but not aphids possessing the other strain. We show that the two symbiont strains encode different toxins, potentially creating different targets for counter‐adaptation. Phenotypic and behavioral comparisons suggest that neither life‐history traits nor oviposition behavior differed among evolved parasitoid lineages. In contrast, comparative transcriptomics of adult female wasps identified a suite of differentially expressed genes among lineages, even when reared in a common, symbiont‐free, aphid host. In concurrence with the specificity of each parasitoid lineages’ infectivity, most differentially expressed parasitoid transcripts were also lineage‐specific. These transcripts are enriched with putative venom toxins and contain highly expressed, potentially defensive viral particles. Together, these results suggest that wild populations of L. fabarum employ a complicated offensive arsenal with sufficient genetic variation for wasps to adapt rapidly and specifically to their hosts’ microbial defenses. KW - Adaptation KW - experimental evolution KW - gene expression KW - Lysiphlebus fabarum KW - parasitoid KW - venom Y1 - 2017 U6 - https://doi.org/10.1111/evo.13333 SN - 0014-3820 SN - 1558-5646 VL - 71 SP - 2599 EP - 2617 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Witt, Barbara A1 - Ebert, Franziska A1 - Meyer, Sören A1 - Francesconi, Kevin A. A1 - Schwerdtle, Tanja T1 - Assessing neurodevelopmental effects of arsenolipids in pre-differentiated human neurons JF - Molecular nutrition & food research : bioactivity, chemistry, immunology, microbiology, safety, technology N2 - Scope: In the general population exposure to arsenic occurs mainly via diet. Highest arsenic concentrations are found in seafood, where arsenic is present predominantly in its organic forms including arsenolipids. Since recent studies have provided evidence that arsenolipids could reach the brain of an organism and exert toxicity in fully differentiated human neurons, this work aims to assess the neurodevelopmental toxicity of arsenolipids. Methods and results: Neurodevelopmental effects of three arsenic-containing hydrocarbons (AsHC), two arsenic-containing fatty acids (AsFA), arsenite and dimethylarsinic acid (DMA(V)) were characterized in pre-differentiated human neurons. AsHCs and arsenite caused substantial cytotoxicity in a similar, low concentration range, whereas AsFAs and DMA(V) were less toxic. AsHCs were highly accessible for cells and exerted pronounced neurodevelopmental effects, with neurite outgrowth and the mitochondrial membrane potential being sensitive endpoints; arsenite did not substantially decrease those two endpoints. In fully differentiated neurons, arsenite and AsHCs caused neurite toxicity. Conclusion: These results indicate for a neurodevelopmental potential of AsHCs. Taken into account the possibility that AsHCs might easily reach the developing brain when exposed during early life, neurotoxicity and neurodevelopmental toxicity cannot be excluded. Further studies are needed in order to progress the urgently needed risk assessment. KW - Arsenic-containing fatty acids KW - Arsenic-containing hydrocarbons KW - Arsenite KW - Arsenolipids KW - Neurodevelopmental toxicity Y1 - 2017 U6 - https://doi.org/10.1002/mnfr.201700199 SN - 1613-4125 SN - 1613-4133 VL - 61 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Mao, Hailiang A1 - Aryal, Bibek A1 - Langenecker, Tobias A1 - Hagmann, Jorg A1 - Geisler, Markus A1 - Grebe, Markus T1 - Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility JF - Nature plants N2 - The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance. Y1 - 2017 U6 - https://doi.org/10.1038/s41477-017-0039-z SN - 2055-026X SN - 2055-0278 VL - 3 SP - 854 EP - 858 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Aichner, Bernhard A1 - Hilt, Sabine A1 - Perillon, Cecile A1 - Gillefalk, Mikael A1 - Sachse, Dirk T1 - Biosynthetic hydrogen isotopic fractionation factors during lipid synthesis in submerged aquatic macrophytes: Effect of groundwater discharge and salinity JF - Organic geochemistry : the international journal for rapid publication of current research in organic geochemistry and biochemistry N2 - Sedimentary lipid biomarkers have become widely used tools for reconstructing past climatic and ecological changes due to their ubiquitous occurrence in lake sediments. In particular, the hydrogen isotopic composition (expressed as delta D values) of leaf wax lipids derived from terrestrial plants has been a focus of research during the last two decades and the understanding of competing environmental and plant physiological factors influencing the delta D values has greatly improved. Comparatively less attention has been paid to lipid biomarkers derived from aquatic plants, although these compounds are abundant in many lacustrine sediments. We therefore conducted a field and laboratory experiment to study the effect of salinity and groundwater discharge on the isotopic composition of aquatic plant biomarkers. We analyzed samples of the common submerged plant species, Potamogeton pectinatus (sago pondweed), which has a wide geographic distribution and can tolerate high salinity. We tested the effect of groundwater discharge (characterized by more negative delta D values relative to lake water) and salinity on the delta D values of n-alkanes from P. pectinatus by comparing plants (i) collected from the oligotrophic freshwater Lake Stechlin (Germany) at shallow littoral depth from locations with and without groundwater discharge, and (ii) plants grown from tubers collected from the eutrophic Lake Muggelsee in nutrient solution at four salinity levels. Isotopically depleted groundwater did not have a significant influence on the delta D values of n-alkanes in Lake Stechlin P. pectinatus and calculated isotopic fractionation factors epsilon(l/w) between lake water and n-alkanes averaged -137 +/- 9%(n-C-23), -136 +/- 7%(n-C-25) and -131 +/- 6%(n-C-27), respectively. Similar epsilon values were calculated for plants from Lake Muggelsee grown in freshwater nutrient solution (-134 +/- 11% for n-C-23), while greater fractionation was observed at increased salinity values of 10 (163 +/- 12%) and 15(-172 +/- 15%). We therefore suggest an average e value of -136 +/- 9% between source water and the major n-alkanes in P. pectinatus grown under freshwater conditions. Our results demonstrate that isotopic fractionation can increase by 30-40% at salinity values 10 and 15. These results could be explained either by inhibited plant growth at higher salinity, or by metabolic adaptation to salt stress that remain to be elucidated. A potential salinity effect on dD values of aquatic lipids requires further examination, since this would impact on the interpretation of downcore isotopic data in paleohydrologic studies. (C) 2017 Elsevier Ltd. All rights reserved. Y1 - 2017 U6 - https://doi.org/10.1016/j.orggeochem.2017.07.021 SN - 0146-6380 VL - 113 SP - 10 EP - 16 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Romero-Diaz, Cristina A1 - Breedveld, Merel Cathelijne A1 - Fitze, Patrick S. T1 - Climate Effects on Growth, Body Condition, and Survival Depend on the Genetic Characteristics of the Population JF - The American naturalist : a bi-monthly journal devoted to the advancement and correlation of the biological sciences N2 - Climatic change is expected to affect individual life histories and population dynamics, potentially increasing vulnerability to extinction. The importance of genetic diversity has been highlighted for adaptation and population persistence. However, whether responses of life-history traits to a given environmental condition depend on the genetic characteristics of a population remains elusive. Here we tested this hypothesis in the lizard Zootoca vivipara by simultaneously manipulating habitat humidity, a major climatic predictor of Zootoca’s distribution, and adult male color morph frequency, a trait with genome-wide linkage. Interactive effects of humidity and morph frequency had immediate effects on growth and body condition of juveniles and yearlings, as well as on adult survival, and delayed effects on offspring size. In yearlings, higher humidity led to larger female body size and lower humidity led to higher male compared to female survival. In juveniles and yearlings, some treatment effects were compensated over time. The results show that individual responses to environmental conditions depend on the population’s color morph frequency, age class, and sex and that these affect intra– and inter–age class competition. Moreover, humidity affected the competitive environment rather than imposing trait-based selection on specific color morphs. This indicates that species’ responses to changing environments (e.g., to climate change) are highly complex and difficult to accurately reconstruct and predict without information on the genetic characteristics and demographic structure of populations. KW - age-structured populations KW - age class effects KW - life-history traits KW - Zootoca vivipara KW - humidity KW - color morph frequency Y1 - 2017 U6 - https://doi.org/10.1086/693780 SN - 0003-0147 SN - 1537-5323 VL - 190 SP - 649 EP - 662 PB - Univ. of Chicago Press CY - Chicago ER - TY - JOUR A1 - Javanainen, Matti A1 - Martinez-Seara, Hector A1 - Metzler, Ralf A1 - Vattulainen, Ilpo T1 - Diffusion of Integral Membrane Proteins in Protein-Rich Membranes JF - The journal of physical chemistry letters N2 - The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbruck (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D proportional to ln(1/R). However, instead of being protein-poor, native cell membranes are extremely crowded with proteins. On the basis of extensive molecular simulations, we here demonstrate that protein crowding of the membrane at physiological levels leads to deviations from the SD relation and to the emergence of a stronger Stokes-like dependence D proportional to 1/R. We propose that this 1/R law mainly arises due to geometrical factors: smaller proteins are able to avoid confinement effects much better than their larger counterparts. The results highlight that the lateral dynamics in the crowded setting found in native membranes is radically different from protein-poor conditions and plays a significant role in formation of functional multiprotein complexes. Y1 - 2017 U6 - https://doi.org/10.1021/acs.jpclett.7b01758 SN - 1948-7185 VL - 8 SP - 4308 EP - 4313 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Steinhöfel, Grit A1 - Breuer, Jörn A1 - von Blanckenburg, Friedhelm A1 - Horn, Ingo A1 - Sommer, Michael T1 - The dynamics of Si cycling during weathering in two small catchments in the Black Forest (Germany) traced by Si isotopes JF - Chemical geology : official journal of the European Association for Geochemistry N2 - Silicon stable isotopes have emerged as a powerful proxy to investigate weathering because Si uptake from solution by secondary minerals or by the vegetation causes significant shifts in the isotope composition. In this study, we determined the Si isotope compositions of the principle Si pools within two small catchments located on sandstone and paragneiss, respectively, in the temperate Black Forest (Germany). At both settings, clay formation is dominated by mineral transformation preserving largely the signature of parental minerals with delta Si-30 values of around -0.7%. Bulk soils rich in primary minerals are similar to bulk parental material with delta Si-30 values close to -0.4%. Topsoils are partly different because organic matter degradation has promoted intense weathering leading to delta Si-30 values as low as -1.0%. Water samples expose highly dynamic weathering processes in the soil zone: 1) after spring snowmelt, increased release of DOC and high water fluxes trigger clay mineral dissolution which leads to delta Si-30 values down to -0.7% and 2) in course of the summer, Si uptake by the vegetation and secondary mineral formation drives dissolved Si to typical positive delta Si-30 values up to 1.1%. Groundwater with delta Si-30 values of around 0.4% records steady processes in bedrock reflecting plagioclase weathering together with kaolinite precipitation. An isotope mass balance approach reveals incongruent weathering conditions where denudation of Si is largely driven by physical erosion. Erosion of phytoliths contributes 3 to 21% to the total Si export flux, which is in the same order as the dissolved Si flux. These results elucidate the Si dynamics during weathering on catchments underlain of sedimentary origin, prevailing on the Earth surface and provide therefore valuable information to interpret the isotope signature of large river systems. KW - Weathering KW - Sedimentary rocks KW - Biogeochemical Si cycle KW - Silicon isotopes KW - UV femtosecond laser ablation Y1 - 2017 U6 - https://doi.org/10.1016/j.chemgeo.2017.06.026 SN - 0009-2541 SN - 1878-5999 VL - 466 SP - 389 EP - 402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Chladkova, Katerina A1 - Hamann, Silke A1 - Williams, Daniel A1 - Hellmuth, Sam T1 - F2 slope as a Perceptual Cue for the Front-Back Contrast in Standard Southern British English JF - Language and speech N2 - Acoustic studies of several languages indicate that second-formant (F2) slopes in high vowels have opposing directions (independent of consonantal context): front [i.]-like vowels are produced with a rising F2 slope, whereas back [u.]-like vowels are produced with a falling F2 slope. The present study first reports acoustic measurements that confirm this pattern for the English variety of Standard Southern British English (SSBE), where /u./ has shifted from the back to the front area of the vowel space and is now realized with higher midpoint F2 values than several decades ago. Subsequently, we test whether the direction of F2 slope also serves as a reliable cue to the /i.// u./ contrast in perception. The findings show that F2 slope direction is used as a cue (additional to midpoint formant values) to distinguish /i./ from /u./by both young and older Standard Southern British English listeners: an otherwise ambiguous token is identified as /i./if it has a rising F2 slope and as /u./if it has a falling F2 slope. Furthermore, our results indicate that listeners generalize their reliance on F2 slope to other contrasts, namely /epsilon/-/./and /ae/-/./, even though F2 slope is not employed to differentiate these vowels in production. This suggests that in Standard Southern British English, a rising F2 seems to be perceptually associated with an abstract feature such as [+ front], whereas a falling F2 with an abstract feature such as [-front]. KW - perceptual cues KW - front-back contrast KW - /u./-fronting KW - Standard Southern British English KW - vowel perception KW - phonological feature Y1 - 2017 U6 - https://doi.org/10.1177/0023830916650991 SN - 0023-8309 SN - 1756-6053 VL - 60 SP - 377 EP - 398 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Brune, Sascha A1 - Corti, Giacomo A1 - Ranalli, Giorgio T1 - Controls of inherited lithospheric heterogeneity on rift linkage: Numerical and analog models of interaction between the Kenyan and Ethiopian rifts across the Turkana depression JF - Tectonics N2 - Inherited rheological structures in the lithosphere are expected to have large impact on the architecture of continental rifts. The Turkana depression in the East African Rift connects the Main Ethiopian Rift to the north with the Kenya rift in the south. This region is characterized by a NW-SE trending band of thinned crust inherited from a Mesozoic rifting event, which is cutting the present-day N-S rift trend at high angle. In striking contrast to the narrow rifts in Ethiopia and Kenya, extension in the Turkana region is accommodated in subparallel deformation domains that are laterally distributed over several hundred kilometers. We present both analog experiments and numerical models that reproduce the along-axis transition from narrow rifting in Ethiopia and Kenya to a distributed deformation within the Turkana depression. Similarly to natural observations, our models show that the Ethiopian and Kenyan rifts bend away from each other within the Turkana region, thus forming a right-lateral step over and avoiding a direct link to form a continuous N-S depression. The models reveal five potential types of rift linkage across the preexisting basin: three types where rifts bend away from the inherited structure connecting via a (1) wide or (2) narrow rift or by (3) forming a rotating microplate, (4) a type where rifts bend towards it, and (5) straight rift linkage. The fact that linkage type 1 is realized in the Turkana region provides new insights on the rheological configuration of the Mesozoic rift system at the onset of the recent rift episode. Plain Language Summary The Turkana depression in the Kenya/Ethiopia borderland is most famous for its several million years old human fossils, but it also holds a rich geological history of continental separation. The Turkana region is a lowland located between the East African and Ethiopian domes because its crust and mantle have been stretched in a continent-wide rift event during Cretaceous times about 140-120 Ma ago. This thin lithosphere exerted paramount control on the dynamics of East African rifting in this area, which commenced around 15 Ma ago and persists until today. Combining analog "sandbox" experiments with numerical geodynamic modeling, we find that inherited rift structures explain the dramatic change in rift style from deep, narrow rift basins north and south of the Turkana area to wide, distributed deformation within the Turkana depression. The failed Cretaceous rift is also responsible for the eastward bend of the Ethiopian rift and the westward bend of the Kenyan rift when entering the Turkana depression, which generated the characteristic hook-shaped form of present-day Lake Turkana. Combing two independent modeling techniques-analog and numerical experiments-is a very promising approach allowing to draw robust conclusions about the processes that shape the surface of our planet. KW - continental rifting KW - east African rift KW - numerical modeling KW - analog modeling KW - tectonic inheritance KW - Turkana depression Y1 - 2017 U6 - https://doi.org/10.1002/2017TC004739 SN - 0278-7407 SN - 1944-9194 VL - 36 SP - 1767 EP - 1786 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Jap, Bernard A. J. A1 - Borleffs, Elisabeth A1 - Maassen, Ben A. M. T1 - Towards identifying dyslexia in Standard Indonesian: the development of a reading assessment battery JF - Reading and writing : an interdisciplinary journal KW - Standard Indonesian KW - Dyslexia KW - Transparent orthography KW - Dyslexia assessment Y1 - 2017 U6 - https://doi.org/10.1007/s11145-017-9748-y SN - 0922-4777 SN - 1573-0905 VL - 30 SP - 1729 EP - 1751 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Ruzanska, Ulrike Alexandra A1 - Warschburger, Petra T1 - Psychometric evaluation of the German version of the Intuitive Eating Scale-2 in a community sample JF - Appetite : multidisciplinary research on eating and drinking KW - Intuitive eating scale KW - Healthy eating behavior KW - Psychometric properties KW - Disordered eating Y1 - 2017 U6 - https://doi.org/10.1016/j.appet.2017.06.018 SN - 0195-6663 SN - 1095-8304 VL - 117 SP - 126 EP - 134 PB - Elsevier CY - London ER - TY - JOUR A1 - Algharably, Engi A. H. A1 - Bolbrinker, Juliane A1 - Lezius, Susanne A1 - Reibis, Rona Katharina A1 - Wegscheider, Karl A1 - Völler, Heinz A1 - Kreutz, Reinhold T1 - Uromodulin associates with cardiorenal function in patients with hypertension and cardiovascular disease JF - Journal of hypertension N2 - Objective:Common genetic variants in the gene encoding uromodulin (UMOD) have been associated with renal function, blood pressure (BP) and hypertension. We investigated the associations between an important single nucleotide polymorphism (SNP) in UMOD, that is rs12917707-G>T, and estimated glomerular filtration rate (eGFR), BP and cardiac organ damage as determined by echocardiography in patients with arterial hypertension.Methods:A cohort of 1218 treated high-risk patients (mean age 58.5 years, 83% men) with documented cardiovascular disease (81% with coronary heart disease) was analysed.Results:The mean values for 24-h SBP and DBP were 124.714.7 and 73.9 +/- 9.4mmHg; mean eGFR was 77.5 +/- 18.3ml/min per 1.73m(2), mean left ventricular ejection fraction was 59.3 +/- 9.9% and mean left ventricular mass index in men and women was 53.9 +/- 23.2 and 54.9 +/- 23.7g/m(2.7) with 50.4% of patients having left ventricular hypertrophy. A significant association between rs12917707 and eGFR was observed with T-allele carriers showing significantly higher eGFR values (+2.6ml/min per 1.73m(2), P=0.006) than noncarriers. This SNP associated also with left atrial diameter (P=0.007); homozygous carriers of the T-allele had smaller left atrial diameter (-1.5mm) than other genotype groups (P=0.040). No significant associations between rs12917707 and other cardiac or BP phenotypes were observed.Conclusions:These findings extend the previously documented role of UMOD for renal function also to treated high-risk patients with arterial hypertension and reveal a novel association with left atrial remodelling and thus a potential cardiorenal link modulated by UMOD. KW - blood pressure KW - cardiovascular complications KW - chronic kidney disease KW - genetics KW - hypertension KW - kidney function KW - organ damage KW - Tamm-Horsfall protein Y1 - 2017 U6 - https://doi.org/10.1097/HJH.0000000000001432 SN - 0263-6352 SN - 1473-5598 VL - 35 SP - 2053 EP - 2058 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - GEN A1 - Balk, Maria A1 - Grijpma, Dirk W. A1 - Lendlein, Andreas T1 - Design and processing of advanced functional polymers for medicine T2 - Polymers for advanced technologies Y1 - 2017 U6 - https://doi.org/10.1002/pat.3980 SN - 1042-7147 SN - 1099-1581 VL - 28 SP - 1203 EP - 1205 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Janhunen, Tomi A1 - Kaminski, Roland A1 - Ostrowski, Max A1 - Schellhorn, Sebastian A1 - Wanko, Philipp A1 - Schaub, Torsten H. T1 - Clingo goes linear constraints over reals and integers JF - Theory and practice of logic programming N2 - The recent series 5 of the Answer Set Programming (ASP) system clingo provides generic means to enhance basic ASP with theory reasoning capabilities. We instantiate this framework with different forms of linear constraints and elaborate upon its formal properties. Given this, we discuss the respective implementations, and present techniques for using these constraints in a reactive context. More precisely, we introduce extensions to clingo with difference and linear constraints over integers and reals, respectively, and realize them in complementary ways. Finally, we empirically evaluate the resulting clingo derivatives clingo[dl] and clingo[lp] on common language fragments and contrast them to related ASP systems. KW - Constraint Answer Set Programming (CASP) KW - Answer Set Programming (ASP) KW - Constraint Processing (CP) KW - Theory Solving Y1 - 2017 U6 - https://doi.org/10.1017/S1471068417000242 SN - 1471-0684 SN - 1475-3081 VL - 17 SP - 872 EP - 888 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Palyulin, Vladimir V. A1 - Mantsevich, Vladimir N. A1 - Klages, Rainer A1 - Metzler, Ralf A1 - Chechkin, Aleksei V. T1 - Comparison of pure and combined search strategies for single and multiple targets JF - The European physical journal : B, Condensed matter and complex systems N2 - We address the generic problem of random search for a point-like target on a line. Using the measures of search reliability and efficiency to quantify the random search quality, we compare Brownian search with Levy search based on long-tailed jump length distributions. We then compare these results with a search process combined of two different long-tailed jump length distributions. Moreover, we study the case of multiple targets located by a Levy searcher. Y1 - 2017 U6 - https://doi.org/10.1140/epjb/e2017-80372-4 SN - 1434-6028 SN - 1434-6036 VL - 90 SP - 20 EP - 37 PB - Springer CY - New York ER - TY - JOUR A1 - Scheel, Tabea A1 - Hoeppner, Dorothea A1 - Grotevendt, Anne A1 - Barthlen, Winfried T1 - Clowns in Paediatric Surgery: Less Anxiety and More Oxytocin? A Pilot Study JF - Klinische Pädiatrie : clinical research and practice in pediatrics N2 - Background Hospital stays and medical interventions are accompanied by worries and anxiety in children and parents. Recent studies show that hospital clowns may reduce anxiety and enhance well-being. However, so far studies are based solely on subjective measures and clowns are usually not integrated in medical routine. With this pilot study, we aim to provide both psychological and physiological evidence of positive effects of clowns’ interventions in hospitalized children. Patients/Method In a consecutive randomized intervention-control group design with 31 children aged 4 to 13 years, 17 patients were accompanied by a clown prior to surgery or during ward round (intervention group) and 14 were not (control group). Saliva samples for oxytocin measurement were taken from all patients before hospitalization (T1) and prior to surgery or after ward round (T2). Self- and parents-reports were obtained at T1, T2 as well as at time of discharge from hospital (T3) regarding children’s anxiety (STAI), worries and well-being. Clowns evaluated their success in cheering up the child. Health professionals were asked for their acceptance of clowns in hospitals. Results Children in the intervention group had lower anxiety ratings and a higher oxytocin concentration at T2 as compared with T1; the control group showed no changes. Parents rated the well-being of their children higher if their child had clown’s contact and were more willing to recommend the hospital. The staff judged the clowns as helpful for patients. Discussion Consistent psychological and physiological results suggest the positive impact of a clown’s intervention in hospitalized children. KW - hospital clowns KW - medical routine KW - oxytocine KW - psychological well-being KW - anxiety KW - childcare Y1 - 2017 U6 - https://doi.org/10.1055/s-0043-106854 SN - 0300-8630 SN - 1439-3824 VL - 229 SP - 274 EP - 280 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Fudickar, Werner A1 - Linker, Torsten T1 - Synthesis of Pyridylanthracenes and Their Reversible Reaction with Singlet Oxygen to Endoperoxides JF - The journal of organic chemistry N2 - The ortho, meta, and para isomers of 9,10-dipyridylanthracene 1 have been synthesized and converted into their endoperoxides 1-O-2 upon oxidation with singlet oxygen. The kinetics of this reaction can be controlled by the substitution pattern and the solvent: in highly polar solvents, the meta isomer is the most reactive, whereas the ortho isomer is oxidized fastest in nonpolar solvents. Heating of the endoperoxides affords the parent anthracenes by release of singlet oxygen. Y1 - 2017 U6 - https://doi.org/10.1021/acs.joc.7b01765 SN - 0022-3263 VL - 82 SP - 9258 EP - 9262 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Bauch, Marcel A1 - Krtitschka, Angela A1 - Linker, Torsten T1 - Photooxygenation of oxygen-substituted naphthalenes JF - Journal of physical organic chemistry N2 - The reaction of oxygen-substituted naphthalenes with singlet oxygen (O-1(2)) has been investigated, and labile endoperoxides have been isolated and characterized at -78 degrees C for the first time. Low-temperature kinetics by UV spectroscopy revealed that alkoxy and silyloxy substituents remarkably increase the rate of photooxygenations compared to 1,4-dimethylnaphthalene, whereas acyloxy-substituted acenes are inert towards O-1(2). The reactivities nicely correlate with HOMO energies and free activation energies, which we determined by density functional theory calculations. The lability of the isolated endoperoxides is due to their very fast back reaction to the corresponding naphthalenes even at -20 degrees C under release of O-1(2), making them to superior sources of this reactive species under very mild conditions. Finally, a carbohydrate-substituted naphthalene has been synthesized, which reacts reversibly with O-1(2) and might be applied for enantioselective oxidations in future work. KW - kinetics KW - labile peroxides KW - low-temperature experiments KW - naphthalenes KW - singlet oxygen Y1 - 2017 U6 - https://doi.org/10.1002/poc.3734 SN - 0894-3230 SN - 1099-1395 VL - 30 SP - 6803 EP - 6813 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Ihmels, Heiko A1 - Linker, Torsten A1 - Trofimov, Aleksei T1 - Editorial T2 - Journal of physical organic chemistry Y1 - 2017 U6 - https://doi.org/10.1002/poc.3745 SN - 0894-3230 SN - 1099-1395 VL - 30 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Simik, Radek A1 - Wierzba, Marta T1 - EXPRESSION OF INFORMATION STRUCTURE IN WEST SLAVIC: MODELING THE IMPACT OF PROSODIC AND WORD-ORDER FACTORS JF - Language : journal of the Linguistic Society of America N2 - The received wisdom is that word-order alternations in Slavic languages arise as a direct consequence of word-order-related information-structure constraints such as ‘Place given expressions before new ones’. In this article, we compare the word-order hypothesis with a competing one, according to which word-order alternations arise as a consequence of a prosodic constraint: ‘Avoid stress on given expressions’. Based on novel experimental and modeling data, we conclude that the prosodic hypothesis is more adequate than the word-order hypothesis. Yet we also show that combining the strengths of both hypotheses provides the best fit for the data. Methodologically, our article is based on gradient acceptability judgments and multiple regression, which allows us to evaluate whether violations of generalizations like ‘Given precedes new’ or ‘Given lacks stress’ lead to a consistent decrease in acceptability and to quantify the size of their respective effects. Focusing on the empirical adequacy of such generalizations rather than on specific theoretical implementations also makes it possible to bridge the gap between different linguistic traditions and to directly compare predictions emerging from formal and functional approaches. KW - information structure KW - givenness KW - word order KW - prosody KW - acceptability-judgment experiments KW - modeling KW - multiple regression KW - Slavic Y1 - 2017 U6 - https://doi.org/10.1353/lan.2017.0040 SN - 0097-8507 SN - 1535-0665 VL - 93 SP - 671 EP - 709 PB - Linguistic Society of America CY - Washington ER - TY - JOUR A1 - Flasch, Leopold A1 - von Elm, Natalie A1 - Wester, Petra T1 - Nectar-drinking Elephantulus edwardii as a potential pollinator of Massonia echinata, endemic to the Bokkeveld plateau in South Africa JF - African journal of ecology Y1 - 2017 U6 - https://doi.org/10.1111/aje.12352 SN - 0141-6707 SN - 1365-2028 VL - 55 SP - 376 EP - 379 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Ryabchun, Alexander A1 - Sakhno, Oksana A1 - Stumpe, Joachim A1 - Bobrovsky, Alexey T1 - Full-Polymer Cholesteric Composites for Transmission and Reflection Holographic Gratings JF - Advanced optical materials N2 - A new type of self-organized materials based on cholesteric networks filled with photoactive side-chain copolymer is being developed. Supramolecular helical structure of cholesteric polymer network resulting in the selective reflection is used as a photonic scaffold. Photochromic azobenzene-containing nematic copolymer is embedded in cholesteric scaffold and utilized as a photoactive media for optical pattering. 1D and 2D transmission diffraction gratings are successfully recorded in composite films by holographic technique. For the first time the possibility to create selective reflection gratings in cholesteric material mimicking the natural optical properties of cholesteric mesophase is demonstrated. That enables the coexistence of two selective gratings, where one has an intrinsic cholesteric periodic helical structure and the other is a holographic grating generated in photochromic polymer. The full-polymer composites provide high light-induced optical anisotropy due to effective photo-orientation of side-chain fragments of the azobenzene-containing liquid crystalline polymer, and prevent the degradation of the helical superstructure maintaining all optical properties of cholesteric mesophase. The proposed class of optical materials could be easily applied to a broad range of polymeric materials with specific functionality. The versatility of the adjustment and material preprogramming combined with high optical performance makes these materials a highly promising candidate for modern optical and photonic applications. KW - azobenzene KW - cholesteric scaffolds KW - holography KW - LC polymer KW - polarization diffraction grating KW - reflection grating Y1 - 2017 U6 - https://doi.org/10.1002/adom.201700314 SN - 2195-1071 VL - 5 SP - 376 EP - 379 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Boers, Niklas A1 - Goswami, Bedartha A1 - Ghil, Michael T1 - A complete representation of uncertainties in layer-counted paleoclimatic archives JF - Climate of the past : an interactive open access journal of the European Geosciences Union N2 - Accurate time series representation of paleoclimatic proxy records is challenging because such records involve dating errors in addition to proxy measurement errors. Rigorous attention is rarely given to age uncertainties in paleoclimatic research, although the latter can severely bias the results of proxy record analysis. Here, we introduce a Bayesian approach to represent layer-counted proxy records - such as ice cores, sediments, corals, or tree rings - as sequences of probability distributions on absolute, error-free time axes. The method accounts for both proxy measurement errors and uncertainties arising from layer-counting-based dating of the records. An application to oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record reveals that the counting errors, although seemingly small, lead to substantial uncertainties in the final representation of the oxygen isotope ratios. In particular, for the older parts of the NGRIP record, our results show that the total uncertainty originating from dating errors has been seriously underestimated. Our method is next applied to deriving the overall uncertainties of the Suigetsu radiocarbon comparison curve, which was recently obtained from varved sediment cores at Lake Suigetsu, Japan. This curve provides the only terrestrial radiocarbon comparison for the time interval 12.5-52.8 kyr BP. The uncertainties derived here can be readily employed to obtain complete error estimates for arbitrary radiometrically dated proxy records of this recent part of the last glacial interval. Y1 - 2017 U6 - https://doi.org/10.5194/cp-13-1169-2017 SN - 1814-9324 SN - 1814-9332 VL - 13 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Rach, Oliver A1 - Engels, S. A1 - Kahmen, A. A1 - Brauer, Achim A1 - Martin-Puertas, C. A1 - van Geel, B. A1 - Sachse, Dirk T1 - Hydrological and ecological changes in western Europe between 3200 and 2000 years BP derived from lipid biomarker delta D values in lake Meerfelder Maar sediments JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - One of the most significant Late Holocene climate shifts occurred around 2800 years ago, when cooler and wetter climate conditions established in western Europe. This shift coincided with an abrupt change in regional atmospheric circulation between 2760 and 2560 cal years BP, which has been linked to a grand solar minimum with the same duration (the Homeric Minimum). We investigated the temporal sequence of hydroclimatic and vegetation changes across this interval of climatic change (Homeric climate oscillation) by using lipid biomarker stable hydrogen isotope ratios (ED values) and pollen assemblages from the annually-laminated sediment record from lake Meerfelder Maar (Germany). Over the investigated interval (3200-2000 varve years BP), terrestrial lipid biomarker ED showed a gradual trend to more negative values, consistent with the western Europe long-term climate trend of the Late Holocene. At ca. 2640 varve years BP we identified a strong increase in aquatic plants and algal remains, indicating a rapid change in the aquatic ecosystem superimposed on this long-term trend. Interestingly, this aquatic ecosystem change was accompanied by large changes in ED values of aquatic lipid biomarkers, such as nC(21) and nC(23) (by between 22 and 30%(0)). As these variations cannot solely be explained by hydroclimate changes, we suggest that these changes in the Wag value were influenced by changes in n-alkane source organisms. Our results illustrate that if ubiquitous aquatic lipid biomarkers are derived from a limited pool of organisms, changes in lake ecology can be a driving factor for variations on sedimentary lipid MN values, which then could be easily misinterpreted in terms of hydro climatic changes. (C) 2017 Elsevier Ltd. All rights reserved. KW - Holocene KW - Climate dynamics KW - Paleoclimatology KW - Western Europe KW - Continental biomarkers KW - Organic geochemistry KW - Stable isotopes KW - Vegetation dynamics Y1 - 2017 U6 - https://doi.org/10.1016/j.quascirev.2017.07.019 SN - 0277-3791 VL - 172 SP - 44 EP - 54 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Caetano, Daniel L. Z. A1 - de Carvalho, Sidney J. A1 - Metzler, Ralf A1 - Cherstvy, Andrey G. T1 - Critical adsorption of periodic and random polyampholytes onto charged surfaces JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - How different are the properties of critical adsorption of polyampholytes and polyelectrolytes onto charged surfaces? How important are the details of polyampholyte charge distribution on the onset of critical adsorption transition? What are the scaling relations governing the dependence of critical surface charge density on salt concentration in the surrounding solution? Here, we employ Metropolis Monte Carlo simulations and uncover the scaling relations for critical adsorption for quenched periodic and random charge distributions along the polyampholyte chains. We also evaluate and discuss the dependence of the adsorbed layer width on solution salinity and details of the charge distribution. We contrast our findings to the known results for polyelectrolyte adsorption onto oppositely charged surfaces, in particular, their dependence on electrolyte concentration. Y1 - 2017 U6 - https://doi.org/10.1039/c7cp04040g SN - 1463-9076 SN - 1463-9084 VL - 19 SP - 23397 EP - 23413 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Muench, Thomas A1 - Kipfstuhl, Sepp A1 - Freitag, Johannes A1 - Meyer, Hanno A1 - Laepple, Thomas T1 - Constraints on post-depositional isotope modifications in East Antarctic firn from analysing temporal changes of isotope profiles JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - The isotopic composition of water in ice sheets is extensively used to infer past climate changes. In low-accumulation regions their interpretation is, however, challenged by poorly constrained effects that may influence the initial isotope signal during and after deposition of the snow. This is reflected in snow-pit isotope data from Kohnen Station, Antarctica, which exhibit a seasonal cycle but also strong interannual variations that contradict local temperature observations. These inconsistencies persist even after averaging many profiles and are thus not explained by local stratigraphic noise. Previous studies have suggested that post-depositional processes may significantly influence the isotopic composition of East Antarctic firn. Here, we investigate the importance of post-depositional processes within the open-porous firn (greater than or similar to 10 cm depth) at Kohnen Station by separating spatial from temporal variability. To this end, we analyse 22 isotope profiles obtained from two snow trenches and examine the temporal isotope modifications by comparing the new data with published trench data extracted 2 years earlier. The initial isotope profiles undergo changes over time due to downward advection, firn diffusion and densification in magnitudes consistent with independent estimates. Beyond that, we find further modifications of the original isotope record to be unlikely or small in magnitude (<< 1 parts per thousand RMSD). These results show that the discrepancy between local temperatures and isotopes most likely originates from spatially coherent processes prior to or during deposition, such as precipitation intermittency or systematic isotope modifications acting on drifting or loose surface snow. Y1 - 2017 U6 - https://doi.org/10.5194/tc-11-2175-2017 SN - 1994-0416 SN - 1994-0424 VL - 11 SP - 2175 EP - 2188 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Rubey, Michael A1 - Brune, Sascha A1 - Heine, Christian A1 - Davies, D. Rhodri A1 - Williams, Simon E. A1 - Müller, R. Dietmar T1 - role of subducted slabs JF - Solid earth Y1 - 2017 U6 - https://doi.org/10.5194/se-8-899-2017 SN - 1869-9510 SN - 1869-9529 VL - 8 SP - 899 EP - 919 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Starkenburg, Else A1 - Martin, Nicolas A1 - Youakim, Kris A1 - Aguado, David S. A1 - Allende Prieto, Carlos A1 - Arentsen, Anke A1 - Bernard, Edouard J. A1 - Bonifacio, Piercarlo A1 - Caffau, Elisabetta A1 - Carlberg, Raymond G. A1 - Cote, Patrick A1 - Fouesneau, Morgan A1 - Francois, Patrick A1 - Franke, Oliver A1 - Gonzalez Hernandez, Jonay I. A1 - Gwyn, Stephen D. J. A1 - Hill, Vanessa A1 - Ibata, Rodrigo A. A1 - Jablonka, Pascale A1 - Longeard, Nicolas A1 - McConnachie, Alan W. A1 - Navarro, Julio F. A1 - Sanchez-Janssen, Ruben A1 - Tolstoy, Eline A1 - Venn, Kim A. T1 - The Pristine survey - I. Mining the Galaxy for the most metal-poor stars JF - Monthly notices of the Royal Astronomical Society N2 - We present the Pristine survey, a new narrow-band photometric survey focused on the metallicity-sensitive Ca H&K lines and conducted in the Northern hemisphere with the wide-field imager MegaCam on the Canada-France-Hawaii Telescope. This paper reviews our overall survey strategy and discusses the data processing and metallicity calibration. Additionally we review the application of these data to the main aims of the survey, which are to gather a large sample of the most metal-poor stars in the Galaxy, to further characterize the faintest Milky Way satellites, and to map the (metal-poor) substructure in the Galactic halo. The current Pristine footprint comprises over 1000 deg(2) in the Galactic halo ranging from b similar to 30 degrees to similar to 78 degrees and covers many known stellar substructures. We demonstrate that, for Sloan Digital Sky Survey (SDSS) stellar objects, we can calibrate the photometry at the 0.02-mag level. The comparison with existing spectroscopic metallicities from SDSS/Sloan Extension for Galactic Understanding and Exploration (SEGUE) and Large Sky Area Multi-Object Fiber Spectroscopic Telescope shows that, when combined with SDSS broad-band g and i photometry, we can use the CaHK photometry to infer photometric metallicities with an accuracy of similar to 0.2 dex from [Fe/H] = -0.5 down to the extremely metal-poor regime ([Fe/H] < -3.0). After the removal of various contaminants, we can efficiently select metal-poor stars and build a very complete sample with high purity. The success rate of uncovering [Fe/H](SEGUE) < -3.0 stars among [Fe/H](Pristine) < -3.0 selected stars is 24 per cent, and 85 per cent of the remaining candidates are still very metal poor ([Fe/H]<-2.0). We further demonstrate that Pristine is well suited to identify the very rare and pristine Galactic stars with [Fe/H] < -4.0, which can teach us valuable lessons about the early Universe. KW - stars: abundances KW - Galaxy: abundances KW - Galaxy: evolution KW - Galaxy: formation KW - Galaxy: halo KW - galaxies: dwarf Y1 - 2017 U6 - https://doi.org/10.1093/mnras/stx1068 SN - 0035-8711 SN - 1365-2966 VL - 471 SP - 2587 EP - 2604 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Bürger, Gerhard T1 - On trend detection JF - Hydrological processes N2 - A main obstacle to trend detection in time series occurs when they are autocorrelated. By reducing the effective sample size of a series, autocorrelation leads to decreased trend significance. Numerous recipes attempt to mitigate the effect of autocorrelation, either by adjusting for the reduced effective sample size or by removing the autocorrelated components of a series. This short note deals with the latter, also called prewhitening (PW). It is known that removal of autocorrelation also removes part of the trend, which may affect the signal-to-noise ratio. Two popular methods have dealt with this problem, the trend-free prewhitening (TFPW) and the iterative prewhitening. Although it is generally accepted that both methods reduce the adverse effects of PW on the trend magnitude, corresponding effects on statistical significance have not been clearly stated for TFPW. Using a Monte Carlo approach, it is demonstrated that both methods entail quite different Type-I error rates. The iterative prewhitening produces rates that are generally close to the nominal significance level. The TFPW, however, shows very high Type-I error rates with increasing autocorrelation. The corresponding rate of false trend detections is unacceptable for applications, so that published trends based on TFPW need to be reassessed. KW - autocorrelation KW - trend significance KW - Type-I error Y1 - 2017 U6 - https://doi.org/10.1002/hyp.11280 SN - 0885-6087 SN - 1099-1085 VL - 31 SP - 4039 EP - 4042 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Erra, Ramon Guevara A1 - Velazquez, Jose L. Perez A1 - Rosenblum, Michael T1 - Neural Synchronization from the Perspective of Non-linear Dynamics T2 - Frontiers in computational neuroscience / Frontiers Research Foundation KW - brain synchronization KW - non-linear dynamics KW - neural synchonization KW - brain rhythms KW - epilepsy Y1 - 2017 U6 - https://doi.org/10.3389/fncom.2017.00098 SN - 1662-5188 VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Nazarova, Larisa B. A1 - Bleibtreu, Annette A1 - Hoff, Ulrike A1 - Dirksen, Veronika A1 - Diekmann, Bernhard T1 - Changes in temperature and water depth of a small mountain lake during the past 3000 years in Central Kamchatka reflected by a chironomid record JF - Quaternary international : the journal of the International Union for Quaternary Research N2 - We investigated chironomid assemblages of a well-dated sediment core from a small seepage lake situated at the eastern slope of the Central Kamchatka Mountain Chain, Far East Russia. The chironomid fauna of the investigated Sigrid Lake is dominated by littoral taxa that are sensitive to fluctuations of the water level. Two groups of taxa interchangeably dominate the record responding to the changes in the lake environment during the past 2800 years. The first group of littoral phytophilic taxa includes Psectrocladius sordidellus-type, Corynoneura arctica-type and Dicrotendipes nervosus-type. The abundances of the taxa from this group have the strongest influence on the variations of PCA 1, and these taxa mostly correspond to low water levels, moderate temperatures and slightly acidified conditions. The second group of taxa includes Microtendipes pedellus-type, Tanytarsus lugens-type, and Tanytarsus pallidicornistype. The variations in the abundances of these taxa, and especially of M. pedellus-type, are in accordance with PCA 2 and correspond to the higher water level in the lake, more oligotrophic and neutral pH conditions. Water depths (WD) were reconstructed, using a modern chironomid-based temperature and water depth calibration data set (training set) and inference model from East Siberia (Nazarova et al., 2011). Mean July air temperatures (T July) were inferred using a chironomid-based temperature inference model based on a modern calibration data set for the Far East (Nazarova et al., 2015). The application of transfer functions resulted in reconstructed T July fluctuations of approximately 3 degrees C over the last 2800 years. Low temperatures (11.0-12.0 degrees C) were reconstructed for the periods between ca 1700 and 1500 cal yr BP (corresponding to the Kofun cold stage) and between ca 1200 and 150 cal yr BP (partly corresponding to the Little Ice Age [LIA]). Warm periods (modern T July or higher) were reconstructed for the periods between ca 2700 and 1800 cal yr BP, 1500 and 1300 cal yr BP and after 150 cal yr BP. WD reconstruction revealed that the lake level was lower than its present level at the beginning of the record between ca 2600 and 2300 cal yr BP and ca 550 cal yr BP. Between ca 2300 and 700 cal yr BP as well as between 450 and 150 cal yr BP, the lake level was higher than it is today, most probably reflecting more humid conditions. (C) 2016 Elsevier Ltd and INQUA. All rights reserved. KW - Kamchatka KW - Chironomids KW - Palaeoclimate KW - Late Holocene KW - Temperature KW - Water depth Y1 - 2017 U6 - https://doi.org/10.1016/j.quaint.2016.10.008 SN - 1040-6182 SN - 1873-4553 VL - 447 SP - 46 EP - 58 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Thamm, Markus A1 - Scholl, Christina A1 - Reim, Tina A1 - Gruebel, Kornelia A1 - Moeller, Karin A1 - Rossler, Wolfgang A1 - Scheiner, Ricarda T1 - Neuronal distribution of tyramine and the tyramine receptor AmTAR1 in the honeybee brain JF - The journal of comparative neurology N2 - Tyramine is an important neurotransmitter, neuromodulator, and neurohormone in insects. In honeybees, it is assumed to have functions in modulating sensory responsiveness and controlling motor behavior. Tyramine can bind to two characterized receptors in honeybees, both of which are coupled to intracellular cAMP pathways. How tyramine acts on neuronal, cellular and circuit levels is unclear. We investigated the spatial brain expression of the tyramine receptor AmTAR1 using a specific antibody. This antibody detects a membrane protein of the expected molecular weight in western blot analysis. In honeybee brains, it labels different structures which process sensory information. Labeling along the antennal nerve, in projections of the dorsal lobe and in the gnathal ganglion suggest that tyramine receptors are involved in modulating gustatory and tactile perception. Furthermore, the ellipsoid body of the central complex and giant synapses in the lateral complex show AmTAR1-like immunoreactivity (AmTAR1-IR), suggesting a role of this receptor in modulating sky-compass information and/or higher sensor-motor control. Additionally, intense signals derive from the mushroom bodies, higher-order integration centers for olfactory, visual, gustatory and tactile information. To investigate whether AmTAR1-expressing brain structures are in vicinity to tyramine releasing sites, a specific tyramine antibody was applied. Tyramine-like labeling was observed in AmTAR1-IR positive structures, although it was sometimes weak and we did not always find a direct match of ligand and receptor. Moreover, tyramine-like immunoreactivity was also found in brain regions without AmTAR1-IR (optic lobes, antennal lobes), indicating that other tyramine-specific receptors may be expressed there. KW - antibody KW - biogenic amines KW - G-protein coupled receptor KW - honeybee KW - tyramine Y1 - 2017 U6 - https://doi.org/10.1002/cne.24228 SN - 0021-9967 SN - 1096-9861 VL - 525 SP - 2615 EP - 2631 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Arora, Ashima A1 - Mawass, Mohamad-Assaad A1 - Sandig, Oliver A1 - Luo, Chen A1 - Uenal, Ahmet A. A1 - Radu, Florin A1 - Valencia, Sergio A1 - Kronast, Florian T1 - Spatially resolved investigation of all optical magnetization switching in TbFe alloys JF - Scientific reports N2 - Optical control of magnetization using femtosecond laser without applying any external magnetic field offers the advantage of switching magnetic states at ultrashort time scales. Recently, all-optical helicity-dependent switching (AO-HDS) has drawn a significant attention for potential information and data storage device applications. In this work, we employ element and magnetization sensitive photoemission electron microscopy (PEEM) to investigate the role of heating in AO-HDS for thin films of the rare-earth transition-metal alloy TbFe. Spatially resolved measurements in a 3–5 μm sized stationary laser spot demonstrate that AO-HDS is a local phenomenon in the vicinity of thermal demagnetization in a ‘ring’ shaped region. The efficiency of AO-HDS further depends on a local temperature profile around the demagnetized region and thermally activated domain wall motion. We also demonstrate that the thickness of the film determines the preferential switching direction for a particular helicity. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-09615-1 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER -