TY - CHAP A1 - Fischer, Saskia M. A1 - Ulbricht, Juliane ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Welche Interventionskompetenzen sind für das Lehrerhandeln in Gewalt- und Mobbingsituationen besonders bedeutsam? T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 255 EP - 275 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Schubarth, Wilfried A1 - Bilz, Ludwig ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Fazit und Folgerungen T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 277 EP - 284 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - BOOK ED - Schweer, Martin K.W. ED - Hascher, Tina ED - Horstkemper, Marianne ED - Melzer, Wolfgang ED - Züchner, Ivo T1 - Lehrer-Schüler-Interaktion BT - Inhaltsfelder, Forschungsperspektiven und methodische Zugänge T3 - Schule und Gesellschaft ; 24 N2 - Eines der zentralen Themen der Schul- und Unterrichtsforschung ist Interaktion im Klassenzimmer, das in diesem Buch umfassend behandelt wird. Was zeichnet die Strukturen des alltäglichen Umgangs im schulischen Kontext aus? Welchen Einfluss hat die Interaktion von Schülerinnen, Schülern und Lehrkräften auf die Unterrichtsqualität? Wo liegen die eigentlichen Problem- und Anwendungsfelder? Antworten auf diese und andere Fragen gibt die überarbeitete und aktualisierte Ausgabe des Buchs, das neue Themen wie ‚Intersektionalität‘ und ‚Inklusionspädagogik‘ aufnimmt. Ein Akzent wird auf die ‚Beratungskompetenz‘ von Lehrerinnen und Lehrern gelegt, die gleichermaßen für Wissenschaft und pädagogische Praxis von Interesse ist. Y1 - 2017 SN - 978-3-658-15082-2 PB - Springer CY - Wiesbaden ET - 3., überarb. u. aktual. ER - TY - JOUR A1 - Krämer, Raimund T1 - Magier der Macht BT - Zum Tode von Fidel Castro Ruz JF - WeltTrends : das außenpolitische Journal Y1 - 2017 SN - 978-3-945878-41-5 SN - 0944-8101 VL - 25 IS - 123 SP - 62 EP - 65 PB - WeltTrends CY - Potsdam ER - TY - BOOK ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Gewalt und Mobbing an Schulen BT - wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen N2 - Wie reagieren Lehrkräfte bei Gewalt und Mobbing? Welche Rolle spielen dabei Wissen, Überzeugungen oder Empathie? Und: Wie hat sich das Ausmaß von Gewalt und Mobbing an deutschen Schulen in den letzten Jahren entwickelt? Auf diese Fragen hat die Forschung bisher kaum Antworten. Der Band stellt die Ergebnisse des von der Deutschen Forschungsgemeinschaft (DFG) geförderten Projektes 'Lehrerhandeln bei Gewalt und Mobbing' vor, das diese Fragen an einer groß angelegten Studie mit über 2000 Schülerinnen und Schülern und 550 Lehrkräften untersucht hat. Sowohl aus Lehrer- als auch aus Schülerperspektive wird erstmals analysiert, wie häufig Lehrerinnen und Lehrer bei Gewaltvorfällen eingreifen und was genau sie mit welchem Ziel und mit welchem Erfolg tun. Die Forschungsergebnisse decken neben Entwicklungstrends insbesondere auf, welche Interventionsstrategien hilfreich sind und was kompetente Lehrerinnen und Lehrer auszeichnet. Folgerungen für die Lehrerbildung und die Schulentwicklung werden gezogen. Der Band richtet sich an einen breiten Adressatenkreis aus den Bereichen Wissenschaft, Lehrerbildung und Schulpraxis. Y1 - 2017 SN - 978-3-7815-2095-0 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Bilz, Ludwig A1 - Schubarth, Wilfried ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Einführung in den Band T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 13 EP - 14 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Bilz, Ludwig A1 - Schubarth, Wilfried A1 - Ulbricht, Juliane ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Der Umgang mit Schülergewalt und -mobbing BT - Ein Modell zu den Bedingungen und Konsequenzen des Lehrerhandel T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 17 EP - 28 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Niproschke, Saskia A1 - Oertel, Lars A1 - Schubarth, Wilfried A1 - Ulbricht, Juliane A1 - Bilz, Ludwig ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Entwicklungstrends von Schülergewalt von Mitte der 1990er Jahre bis heute T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 39 EP - 56 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Seidel, Andreas A1 - Oertel, Lars ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Eine Systemaik der Interventionsformen und -ziele bei Gewalt und Mobbing BT - Ergebnisse der Vorstudie T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 89 EP - 101 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Ulbricht, Juliane ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Exkurs: Lehrerhandeln bei Gewalt und Mobbing - angehende, berufseinsteigende und erfahrene Lehrkräfte im Vergleich T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 129 EP - 143 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - CHAP A1 - Niproschke, Saskia A1 - Bilz, Ludwig A1 - Dudziak, Ines ED - Bilz, Ludwig ED - Schubarth, Wilfried ED - Dudziak, Ines ED - Fischer, Saskia M. ED - Niproschke, Saskia ED - Ulbricht, Juliane T1 - Welche Kontextfaktoren sind für das Lehrerhandeln bei Mobbing von Bedeutung? T2 - Gewalt und Mobbing an Schulen : wie sich Gewalt und Mobbing entwickelt haben, wie Lehrer intervenieren und welche Kompetenzen sie brauchen Y1 - 2017 SN - 978-3-7815-2095-0 SP - 145 EP - 165 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - BOOK A1 - Gil, Thomas T1 - Things, Properties, and Relations Y1 - 2017 SN - 978-3-945878-39-2 PB - WeltTrends CY - Potsdam ER - TY - JOUR A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Competing Biases in Mental Arithmetic BT - When Division Is More and Multiplication Is Less JF - Frontiers in human neuroscience N2 - Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such “operational momentum” (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic. KW - heuristics and biases KW - numerical cognition KW - mental arithmetic KW - mental number line KW - operational momentum Y1 - 2017 U6 - https://doi.org/10.3389/fnhum.2017.00037 SN - 1662-5161 VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - THES A1 - Ohligschlaeger-Lim, Kerstin ED - Haßler, Gerda T1 - Erkenntnistheorie im ausgehenden 18. Jahrhundert in Frankreich BT - eine Neubetrachtung des Pariser Wettbewerbs zur Frage nach dem Einfluss der Zeichen auf das Denken (1797/99) T2 - Studium Sprachwissenschaft / Beiheft ; 44 N2 - 1. Einleitung: Gegenstand und Vorgehensweise (Ziel und Anliegen der Arbeit / Forschungsstand / Methode) ― 2. Die Ideologen und die Seconde Classe des Institut national (Etienne Bonnot de Condillac als Referenz der Ideologen / Antoine Laurent de Lavoisier und die Nomenklatur der Chemie (1787) / Die Grup¬pe der Ideologen / Institutionelle Wirkungsmöglichkeiten der Ideologen: Die Classe des Sciences morales et politiques am Institut national / Vorlesungen in der Ecole normale de l’an III ) ― 3. Zum Korpus: Rekonstruktion der Ausschreibung (The¬men¬findung und Ausschreibung / Die erste Bewertung (1797) und die Neuausschreibung / Die zweite Bewertung (1799): Bekanntgabe des Gewinners) ― 4. Das archivalische Korpus (Zur Auffindsituation der Preisbewerbungsschriften / Serie B1 (1797) / Serie B2 (1799)) ― 5. Auswertung des Korpus: Übergreifende Topoi und Argumentationsstrukturen (Semiotisierung und Entsemiotisierung / Der Nutzen der Analyse / Hervorhebung der Schriftsprache gegenüber der Lautsprache / Das Mate¬ria¬lisieren / Die Zeichen der Mathematik als Vorbild) ― 6. Schlussbetrachtungen ― Literatur Y1 - 2017 SN - 978-3-89323-144-7 PB - Nodus CY - Münster ER - TY - JOUR A1 - Stillmark, Hans-Christian A1 - Krüger, Brigitte T1 - Dekonstruktion von Künstlermythen BT - Daniel Kehlmann: Ruhm und Michel Houllebecq: Karte und Gebiet JF - Mythos No. 4 : Philologische Mythosforschung = Mythos : fächerübergreifendes Forum für Mythosforschung KW - Mythos KW - Dekonstruktion Y1 - 2017 SN - 978-3-8260-5955-1 VL - 4 SP - 78 EP - 98 PB - Königshausen & Neumann CY - Würzburg ER - TY - THES A1 - Denoyer, Aurélie T1 - L'exil comme patrie BT - Les réfugiés communistes espagnols en RDA (1950-1989) Y1 - 2017 SN - 978-2-7535-5196-1 PB - Press Universitaires CY - Rennes ER - TY - JOUR A1 - Romano, Francesco T1 - TTIP and Free Trade Agreements between the European Union and Thrid Countries JF - Developing Intra-regional Exchanges through the Abolition of Commercial and Tariff Barriers : Myth or Reality? (Cultures juridiques et politiques ; 10) JF - L’abolition des barrières commerciales et tarifaires dans la région de l’Océan indien : Mythe ou réalité? (Cultures juridiques et politiques ; 10) Y1 - 2017 SN - 978-2-8076-0126-0 U6 - https://doi.org/10.3726/978-2-8076-0127-7 SN - 2235-1078 SP - 79 EP - 95 PB - Lang CY - Bruxelles ER - TY - JOUR A1 - Kappler, Johannes T1 - The Free Flow of Financial Services in Europa and the Access of Non-European Financial Service Providers to the European Market JF - Developing Intra-regional Exchanges through the Abolition of Commercial and Tariff Barriers : Myth or Reality? (Cultures juridiques et politiques ; 10) JF - L’abolition des barrières commerciales et tarifaires dans la région de l’Océan indien : Mythe ou réalité? (Cultures juridiques et politiques ; 10) Y1 - 2017 SN - 978-2-8076-0126-0 U6 - https://doi.org/10.3726/978-2-8076-0127-7 SN - 2235-1078 SP - 97 EP - 114 PB - Lang CY - Bruxelles ER - TY - JOUR A1 - Fritz, Maximilian T1 - International Commercial Arbitration n the Framwork of the WTO JF - Developing Intra-regional Exchanges through the Abolition of Commercial and Tariff Barriers : Myth or Reality? (Cultures juridiques et politiques ; 10) JF - L’abolition des barrières commerciales et tarifaires dans la région de l’Océan indien : Mythe ou réalité? (Cultures juridiques et politiques ; 10) Y1 - 2017 SN - 978-2-8076-0126-0 U6 - https://doi.org/10.3726/978-2-8076-0127-7 SN - 2235-1078 SP - 395 EP - 409 PB - Lang CY - Bruxelles ER - TY - JOUR A1 - Hamou, Sarah T1 - The Indian Ocean BT - A strategic Maritime Space for Trade JF - Developing Intra-regional Exchanges through the Abolition of Commercial and Tariff Barriers : Myth or Reality? (Cultures juridiques et politiques ; 10) JF - L’abolition des barrières commerciales et tarifaires dans la région de l’Océan indien : Mythe ou réalité? (Cultures juridiques et politiques ; 10) Y1 - 2017 SN - 978-2-8076-0126-0 U6 - https://doi.org/10.3726/978-2-8076-0127-7 SN - 2235-1078 SP - 425 EP - 433 PB - Lang CY - Bruxelles ER - TY - THES A1 - Neuhaus, Christian T1 - Sicherheitsmechanismen für dienstbasierte Softwaresysteme Y1 - 2017 ER - TY - JOUR A1 - Bandara, Lashi A1 - McIntosh, Alan A1 - Rosen, Andreas T1 - Riesz continuity of the Atiyah BT - singer dirac operator under perturbations of the metric JF - Mathematische Annalen N2 - We prove that the Atiyah–Singer Dirac operator in L2 depends Riesz continuously on L∞ perturbations of complete metrics g on a smooth manifold. The Lipschitz bound for the map depends on bounds on Ricci curvature and its first derivatives as well as a lower bound on injectivity radius. Our proof uses harmonic analysis techniques related to Calderón’s first commutator and the Kato square root problem. We also show perturbation results for more general functions of general Dirac-type operators on vector bundles. Y1 - 2017 U6 - https://doi.org/10.1007/s00208-017-1610-7 SN - 0025-5831 SN - 1432-1807 VL - 370 IS - 1-2 SP - 863 EP - 915 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Marco, Makungu A1 - Deyou, Tsegaye A1 - Gruhonjic, Amra A1 - Holleran, John A1 - Duffy, Sandra A1 - Heydenreich, Matthias A1 - Firtzpatrick, Paul A. A1 - Landberg, Goran A1 - Koch, Andreas A1 - Derese, Solomon A1 - Pelletier, Jerry A1 - Avery, Vicky M. A1 - Erdelyi, Mate A1 - Yenesew, Abiy T1 - Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura JF - Phytochemistry letters KW - Millettia micans KW - Millettia dura KW - Pterocarpan KW - Isoflavone KW - Cytotoxicity KW - Plasmodium falciparum Y1 - 2017 U6 - https://doi.org/10.1016/j.phytol.2017.07.012 SN - 1874-3900 SN - 1876-7486 VL - 21 SP - 216 EP - 220 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Müller, Juliane A1 - Hadzic, Miralem A1 - Mugele, Hendrik A1 - Stoll, Josefine A1 - Müller, Steffen A1 - Mayer, Frank T1 - Effect of high-intensity perturbations during core-specific sensorimotor exercises on trunk muscle activation JF - Journal of biomechanics N2 - Core-specific sensorimotor exercises are proven to enhance neuromuscular activity of the trunk. However, the influence of high-intensity perturbations on training efficiency is unclear within this context. Sixteen participants (29 +/- 2 yrs; 175 +/- 8 cm; 69 +/- 13 kg) were prepared with a 12-lead bilateral trunk EMG. Warm-up on a dynamometer was followed by maximum voluntary isometric trunk (flex/ext) contraction (MVC). Next, participants performed four conditions for a one-legged stance with hip abduction on a stable surface (HA) repeated randomly on an unstable surface (HAP), on a stable surface with perturbation (HA + P), and on an unstable surface with perturbation (HAP + P). Afterwards, bird dog (BD) was performed under the same conditions (BD, BDP, BD + P, BDP + P). A foam pad under the foot (HA) or the knee (BD) was used as an unstable surface. Exercises were conducted on a moveable platform. Perturbations (ACC 50 m/sec(2);100 ms duration;10rep.) were randomly applied in the anterior-posterior direction. The root mean square (RMS) normalized to MVC (%) was calculated (whole movement cycle). Muscles were grouped into ventral right and left (VR;VL), and dorsal right and left (DR;DL). Ventral Dorsal and right-left ratios were calculated (two way repeated-measures ANOVA;alpha = 0,05). Amplitudes of all muscle groups in bird dog were higher compared to hip abduction (p <= 0.0001; Range: BD: 14 +/- 3% (BD;VR) to 53 +/- 4%; HA: 7 +/- 2% (HA;DR) to 16 +/- 4% (HA;DR)). EMG-RMS showed significant differences (p < 0.001) between conditions and muscle groups per exercise. Interaction effects were only significant for HA (p = 0.02). No significant differences were present in EMG ratios (p > 0.05). Additional high-intensity perturbations during core-specific sensorimotor exercises lead to increased neuromuscular activity and therefore higher exercise intensities. However, the beneficial effects on trunk function remain unclear. Nevertheless, BD is more suitable to address trunk muscles. KW - Split-belt treadmill KW - EMG KW - Core stability KW - MiSpEx Y1 - 2017 U6 - https://doi.org/10.1016/j.jbiomech.2017.12.013 SN - 0021-9290 SN - 1873-2380 VL - 70 SP - 212 EP - 218 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Atilaw, Yoseph A1 - Duffy, Sandra A1 - Heydenreich, Matthias A1 - Muiva-Mutisya, Lois A1 - Avery, Vicky M. A1 - Erdelyi, Mate A1 - Yenesew, Abiy T1 - Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata JF - Molecules N2 - In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2,6-dimethoxy-3,4-(2,2-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2,6-dimethoxy-3,4-(2,2-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4-ethoxy-3-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. KW - Tephrosia aequilata KW - chalcone KW - retrochalcone KW - aequichalcone A KW - aequichalcone B KW - aequichalcone C KW - pterocarpene KW - antiplasmodial Y1 - 2017 U6 - https://doi.org/10.3390/molecules22020318 SN - 1420-3049 VL - 22 IS - 2 PB - MDPI CY - Basel ER - TY - GEN A1 - Limberger, Daniel A1 - Scheibel, Willy A1 - Trapp, Matthias A1 - Döllner, Jürgen Roland Friedrich T1 - Mixed-projection treemaps BT - a novel approach mixing 2D and 2.5D treemaps T2 - 21st International Conference Information Visualisation (IV) N2 - This paper presents a novel technique for combining 2D and 2.5D treemaps using multi-perspective views to leverage the advantages of both treemap types. It enables a new form of overview+detail visualization for tree-structured data and contributes new concepts for real-time rendering of and interaction with treemaps. The technique operates by tilting the graphical elements representing inner nodes using affine transformations and animated state transitions. We explain how to mix orthogonal and perspective projections within a single treemap. Finally, we show application examples that benefit from the reduced interaction overhead. KW - Information Visualization KW - Overview plus Detail KW - Treemaps KW - 2.5D Treemaps KW - Multi-perspective Views Y1 - 2017 SN - 978-1-5386-0831-9 U6 - https://doi.org/10.1109/iV.2017.67 SN - 2375-0138 SP - 164 EP - 169 PB - Institute of Electrical and Electronics Engineers CY - Los Alamitos ER - TY - JOUR A1 - Nagel, Rebecca A1 - Kirschbaum, Frank A1 - Tiedemann, Ralph T1 - Electric organ discharge diversification in mormyrid weakly electric fish is associated with differential expression of voltage-gated ion channel genes JF - Journal of comparative physiology : A, Neuroethology, sensory, neural, and behavioral physiology N2 - In mormyrid weakly electric fish, the electric organ discharge (EOD) is used for species recognition, orientation and prey localization. Produced in the muscle-derived adult electric organ, the EOD exhibits a wide diversity across species in both waveform and duration. While certain defining EOD characteristics can be linked to anatomical features of the electric organ, many factors underlying EOD differentiation are yet unknown. Here, we report the differential expression of 13 Kv1 voltage-gated potassium channel genes, two inwardly rectifying potassium channel genes, two previously studied sodium channel genes and an ATPase pump in two sympatric species of the genus Campylomormyrus in both the adult electric organ and skeletal muscle. Campylomormyrus compressirostris displays a basal EOD, largely unchanged during development, while C. tshokwe has an elongated, putatively derived discharge. We report an upregulation in all Kv1 genes in the electric organ of Campylomormyrus tshokwe when compared to both skeletal muscle and C. compressirostris electric organ. This pattern of upregulation in a species with a derived EOD form suggests that voltage-gated potassium channels are potentially involved in the diversification of the EOD signal among mormyrid weakly electric fish. KW - Weakly electric fish KW - Ion channels KW - Electric organ KW - Gene expression KW - Campylomormyrus Y1 - 2017 U6 - https://doi.org/10.1007/s00359-017-1151-2 SN - 0340-7594 SN - 1432-1351 VL - 203 SP - 183 EP - 195 PB - Springer CY - New York ER - TY - JOUR A1 - Albrecht, Anna Helena T1 - Zur Strafbarkeit des Vorgesetzten bei Straftatbegehung durch Untergebene BT - Teil 1 Strafbarkeit durch aktives Tun JF - studere : Rechtszeitschrift der Universität Potsdam Y1 - 2017 SN - 1867-6170 VL - 2017 IS - 18 SP - 22 EP - 28 PB - studere e.V. CY - Potsdam ER - TY - JOUR A1 - Bäurle, Isabel T1 - Can't remember to forget you BT - Chromatin-based priming of somatic stress responses JF - Seminars in cell & developmental biology N2 - In nature plants are exposed to frequent changes in their abiotic and biotic environment. While some environmental cues are used to gauge the environment and align growth and development, others are beyond the regularly encountered spectrum of a species and trigger stress responses. Such stressful conditions provide a potential threat to survival and integrity. Plants adapt to extreme environmental conditions through physiological adaptations that are usually transient and are maintained until stressful environments subside. It is increasingly appreciated that in some cases environmental cues activate a stress memory that persists for some time after the extreme condition has subsided. Recent research has shown that this stress-induced environmental memory is mediated by epigenetic and chromatin-based mechanisms and both histone methylation and nucleosome occupancy are associated with it. KW - Priming KW - Transcriptional memory KW - Chromatin KW - H3K4 methylation KW - Nucleosome occupancy Y1 - 2017 U6 - https://doi.org/10.1016/j.semcdb.2017.09.032 SN - 1084-9521 VL - 83 SP - 133 EP - 139 PB - Elsevier CY - London ER - TY - JOUR A1 - Fliesser, Michael A1 - De Witt Huberts, Jessie A1 - Wippert, Pia-Maria T1 - The choice that matters: the relative influence of socioeconomic status indicators on chronic back pain BT - a longitudinal study JF - BMC health services research N2 - Background In health research, indicators of socioeconomic status (SES) are often used interchangeably and often lack theoretical foundation. This makes it difficult to compare results from different studies and to explore the relationship between SES and health outcomes. To aid researchers in choosing appropriate indicators of SES, this article proposes and tests a theory-based selection of SES indicators using chronic back pain as a health outcome. Methods Strength of relationship predictions were made using Brunner & Marmot’s model of ‘social determinants of health’. Subsequently, a longitudinal study was conducted with 66 patients receiving in-patient treatment for chronic back pain. Sociodemographic variables, four SES indicators (education, job position, income, multidimensional index) and back pain intensity and disability were obtained at baseline. Both pain dimensions were assessed again 6 months later. Using linear regression, the predictive strength of each SES indicator on pain intensity and disability was estimated and compared to the theory based prediction. Results Chronic back pain intensity was best predicted by the multidimensional index (beta = 0.31, p < 0.05), followed by job position (beta = 0.29, p < 0.05) and education (beta = −0.29, p < 0.05); whereas, income exerted no significant influence. Back pain disability was predicted strongest by education (beta = −0.30, p < 0.05) and job position (beta = 0.29, p < 0.05). Here, multidimensional index and income had no significant influence. Conclusions The choice of SES indicators influences predictive power on both back pain dimensions, suggesting SES predictors cannot be used interchangeably. Therefore, researchers should carefully consider prior to each study which SES indicator to use. The introduced framework can be valuable in supporting this decision because it allows for a stable prediction of SES indicator influence and their hierarchy on a specific health outcomes. KW - Socioeconomic status KW - Indicators of socioeconomic status, Health inequality KW - Education KW - Job position KW - Income KW - Chronic back pain Y1 - 2017 U6 - https://doi.org/10.1186/s12913-017-2735-9 SN - 1472-6963 VL - 17 PB - BioMed Central CY - London ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Rector, Michael V. A1 - Kuhn, Gisela A1 - Wuertz-Kozak, Karin T1 - Stress and Alterations in Bones BT - An Interdisciplinary Perspective JF - Frontiers in endocrinology N2 - Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions. KW - biomechanics KW - bone–brain–nervous system interactions KW - endocrine pathways KW - osteoporosis KW - exercise Y1 - 2017 U6 - https://doi.org/10.3389/fendo.2017.00096 SN - 1664-2392 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Fliesser, Michael A1 - Krause, Matthias T1 - Risk and protective factors in the clinical rehabilitation of chronic back pain JF - Journal of pain research N2 - Objectives: Chronic back pain (CBP) can lead to disability and burden. In addition to its medical causes, its development is influenced by psychosocial risk factors, the so-called flag factors, which are categorized and integrated into many treatment guidelines. Currently, most studies investigate single flag factors, which limit the estimation of individual factor significance in the development of chronic pain. Furthermore, factors concerning patients’ lifestyle, biography and treatment history are often neglected. Therefore, the objectives of the present study are to identify commonly neglected factors of CBP and integrate them into an analysis model comparing their significance with established flag factors. Methods: A total of 24 patients and therapists were cross-sectionally interviewed to identify commonly neglected factors of CBP. Subsequently, the impact of these factors was surveyed in a longitudinal study. In two rehabilitation clinics, CBP patients (n = 145) were examined before and 6 months after a 3-week inpatient rehabilitation. Outcome variables, chronification factor pain experience (CF-PE) and chronification factor disability (CF-D), were ascertained with confirmatory factor analysis (CFA) of standardized questionnaires. Predictors were evaluated using stepwise calculations of simple and multiple regression models. Results: Through interviews, medical history, iatrogenic factors, poor compliance, critical life events (LEs), social support (SS) type and effort–reward were identified as commonly neglected factors. However, only the final three held significance in comparison to established factors such as depression and pain-related cognitions. Longitudinally, lifestyle factors found to influence future pain were initial pain, physically demanding work, nicotine consumption, gender and rehabilitation clinic. LEs were unexpectedly found to be a strong predictor of future pain, as were the protective factors, reward at work and perceived SS. Discussion: These findings shed insight regarding often overlooked factors in the development of CBP, suggesting that more detailed operationalization and superordinate frameworks would be beneficial to further research. Conclusion: In particular, LEs should be taken into account in future research. Protective factors should be integrated in therapeutic settings. KW - yellow flags KW - life events KW - clinical pain research Y1 - 2017 U6 - https://doi.org/10.2147/JPR.S134976 SN - 1178-7090 VL - 10 SP - 1569 EP - 1579 PB - Dove Medical Press CY - Albany, Auckland ER - TY - JOUR A1 - Fliesser, Michael A1 - De Witt Huberts, Jessie A1 - Wippert, Pia-Maria T1 - The choice that matters: the relative influence of socioeconomic status indicators on chronic back pain- a longitudinal study JF - BMC health services research N2 - Background: In health research, indicators of socioeconomic status (SES) are often used interchangeably and often lack theoretical foundation. This makes it difficult to compare results from different studies and to explore the relationship between SES and health outcomes. To aid researchers in choosing appropriate indicators of SES, this article proposes and tests a theory-based selection of SES indicators using chronic back pain as a health outcome. Results: Chronic back pain intensity was best predicted by the multidimensional index (beta = 0.31, p < 0.05), followed by job position (beta = 0.29, p < 0.05) and education (beta = -0.29, p < 0.05); whereas, income exerted no significant influence. Back pain disability was predicted strongest by education (beta = -0.30, p < 0.05) and job position (beta = 0. 29, p < 0.05). Here, multidimensional index and income had no significant influence. Conclusions: The choice of SES indicators influences predictive power on both back pain dimensions, suggesting SES predictors cannot be used interchangeably. Therefore, researchers should carefully consider prior to each study which SES indicator to use. The introduced framework can be valuable in supporting this decision because it allows for a stable prediction of SES indicator influence and their hierarchy on a specific health outcomes. KW - socioeconomic status KW - Indicators of socioeconomic status KW - health inequality KW - education KW - job position KW - income KW - chronic back pain Y1 - 2017 U6 - https://doi.org/10.1186/s12913-017-2735-9 SN - 1472-6963 VL - 17 PB - BioMed Central CY - London ER - TY - JOUR A1 - Auyyuenyong, Ratchada A1 - Henze, Andrea A1 - Ungru, Julia A1 - Schweigert, Florian Johannes A1 - Raila, Jens A1 - Vervuert, Ingrid T1 - Determination of lipid profiles in serum of obese ponies before and after weight reduction by using multi-one-dimensional thin-layer chromatography JF - Research in veterinary science N2 - Obesity is a key component of equine metabolic syndrome, which is highly associated with laminitis. Feed restriction and/or exercise are known to alleviate the detrimental effects of insulin resistance in obese ponies. However, little is known about changes in the serum lipid patterns due to weight reduction and its association with disease outcomes. Therefore, the lipid patterns in the serum of 14 mature ponies before and after a 14-week body weight reduction program (BWRP) were investigated by multi-one-dimensional thin-layer chromatography (MOD-TLC). Additionally, sensitivity to insulin (SI), body condition scores (BCS) and cresty neck scores (CNS) were measured. A BWRP resulted in a significant loss of body weight (P < 0.001), which was associated with beneficial decreases in BCS and CNS (both, P < 0.001). Serum lipid compositions revealed significantly increased free fatty acid (FFA), sphingomyelin (SM; both P < 0.001), total cholesterol (C) and cholesterol ester (CE) (both P < 0.01) and triacylglycerol (TG; P < 0.05) densities. Improvement of SI after the BWRP was associated with increases in neutral lipids (C, CE and TG, all P < 0.01), FFA and the phospholipid SM (both, P < 0.001). The results show that a BWRP in obese ponies was effective and associated with changes in the concentrations of neutral lipids and the phospholipid SM, indicating that SM may play a role in insulin signaling pathways and thus in the pathogenesis of insulin resistance and the progression of metabolic syndrome in obese ponies. KW - Neutral lipids KW - Equine metabolic syndrome KW - Phospholipids KW - Horse KW - Thin layer chromatography Y1 - 2017 U6 - https://doi.org/10.1016/j.rvsc.2017.11.013 SN - 0034-5288 SN - 1532-2661 VL - 117 SP - 111 EP - 117 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Schlägel, Ulrike E. A1 - Merrill, Evelyn H. A1 - Lewis, Mark A. T1 - Territory surveillance and prey management: Wolves keep track of space and time JF - Ecology and evolution N2 - Identifying behavioral mechanisms that underlie observed movement patterns is difficult when animals employ sophisticated cognitive‐based strategies. Such strategies may arise when timing of return visits is important, for instance to allow for resource renewal or territorial patrolling. We fitted spatially explicit random‐walk models to GPS movement data of six wolves (Canis lupus; Linnaeus, 1758) from Alberta, Canada to investigate the importance of the following: (1) territorial surveillance likely related to renewal of scent marks along territorial edges, to reduce intraspecific risk among packs, and (2) delay in return to recently hunted areas, which may be related to anti‐predator responses of prey under varying prey densities. The movement models incorporated the spatiotemporal variable “time since last visit,” which acts as a wolf's memory index of its travel history and is integrated into the movement decision along with its position in relation to territory boundaries and information on local prey densities. We used a model selection framework to test hypotheses about the combined importance of these variables in wolf movement strategies. Time‐dependent movement for territory surveillance was supported by all wolf movement tracks. Wolves generally avoided territory edges, but this avoidance was reduced as time since last visit increased. Time‐dependent prey management was weak except in one wolf. This wolf selected locations with longer time since last visit and lower prey density, which led to a longer delay in revisiting high prey density sites. Our study shows that we can use spatially explicit random walks to identify behavioral strategies that merge environmental information and explicit spatiotemporal information on past movements (i.e., “when” and “where”) to make movement decisions. The approach allows us to better understand cognition‐based movement in relation to dynamic environments and resources. KW - animal movement KW - cognition KW - GPS data KW - landscape of fear KW - movement ecology KW - predator-prey KW - spatial memory KW - step selection KW - territoriality KW - time since last visit Y1 - 2017 U6 - https://doi.org/10.1002/ece3.3176 SN - 2045-7758 VL - 7 SP - 8388 EP - 8405 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Eckstein, Lars A1 - Peitsch, Helmut A1 - Schwarz, Anja T1 - Tusitalas Wandlungen BT - Spuren Robert Louis Stevensons in deutscher Literatur über Samoa JF - Pazifikismus : Poetiken des Stillen Ozeans Y1 - 2017 SN - 978-3-8260-6169-1 SP - 443 EP - 460 PB - Königshausen & Neumann CY - Würzburg ER - TY - THES A1 - Weitkunat, Karolin T1 - Dietary fibers and short-chain fatty acids in the development of diet-induced obesity Y1 - 2017 ER - TY - JOUR A1 - Meyer, Irene A1 - Peter, Tatjana A1 - Batsios, Petros A1 - Kuhnert, Oliver A1 - Krueger-Genge, Anne A1 - Camurca, Carl A1 - Gräf, Ralph T1 - CP39, CP75 and CP91 are major structural components of the Dictyostelium JF - European journal of cell biology N2 - The acentriolar Dictyostelium centrosome is a nucleus-associated body consisting of a core structure with three plaque-like layers, which are surrounded by a microtubule-nucleating corona. The core duplicates once per cell cycle at the G2/M transition, whereby its central layer disappears and the two outer layers form the mitotic spindle poles. Through proteomic analysis of isolated centrosomes, we have identified CP39 and CP75, two essential components of the core structure. Both proteins can be assigned to the central core layer as their centrosomal presence is correlated to the disappearance and reappearance of the central core layer in the course of centrosome duplication. Both proteins contain domains with centrosome-binding activity in their N- and C-terminal halves, whereby the respective N-terminal half is required for cell cycle-dependent regulation. CP39 is capable of self-interaction and GFP-CP39 overexpression elicited supernumerary microtubule-organizing centers and pre-centrosomal cytosolic clusters. Underexpression stopped cell growth and reversed the MTOC amplification phenotype. In contrast, in case of CP75 underexpression of the protein by RNAi treatment elicited supernumerary MTOCs. In addition, CP75RNAi affects correct chromosome segregation and causes co-depletion of CP39 and CP91, another central core layer component. CP39 and CP75 interact with each other directly in a yeast two-hybrid assay. Furthermore, CP39, CP75 and CP91 mutually interact in a proximity-dependent biotin identification (BioID) assay. Our data indicate that these three proteins are all required for proper centrosome biogenesis and make up the major structural components of core structure's central layer. KW - Dictyostelium KW - Mitosis KW - Microtubules KW - Centrosome KW - Nucleus Y1 - 2017 U6 - https://doi.org/10.1016/j.eicb.2017.01.004 SN - 0171-9335 SN - 1618-1298 VL - 96 SP - 119 EP - 130 PB - Elsevier CY - Jena ER - TY - JOUR A1 - von Loeffelholz, Christian A1 - Lieske, Stefanie A1 - Neuschaefer-Rube, Frank A1 - Willmes, Diana M. A1 - Raschzok, Nathanael A1 - Sauer, Igor M. A1 - König, Jörg A1 - Fromm, Martin F. A1 - Horn, Paul A1 - Chatzigeorgiou, Antonios A1 - Pathe-Neuschaefer-Rube, Andrea A1 - Jordan, Jens A1 - Pfeiffer, Andreas F. H. A1 - Mingrone, Geltrude A1 - Bornstein, Stefan R. A1 - Stroehle, Peter A1 - Harms, Christoph A1 - Wunderlich, F. Thomas A1 - Helfand, Stephen L. A1 - Bernier, Michel A1 - de Cabo, Rafael A1 - Shulman, Gerald I. A1 - Chavakis, Triantafyllos A1 - Püschel, Gerhard Paul A1 - Birkenfeld, Andreas L. T1 - The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism BT - official journal of the American Association for the Study of Liver Diseases JF - Hepatology N2 - Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450. Y1 - 2017 U6 - https://doi.org/10.1002/hep.29089 SN - 0270-9139 SN - 1527-3350 VL - 66 IS - 2 SP - 616 EP - 630 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - McLaughlin, Carly T1 - They don’t look like children BT - child asylum-seekers, the Dubs amendment and the politics of childhood JF - Journal of Ethnic and Migration Studies N2 - In October 2016, following a campaign led by Labour Peer Lord Alfred Dubs, the first child asylum-seekers allowed entry to the UK under new legislation (the ‘Dubs amendment’) arrived in England. Their arrival was captured by a heavy media presence, and very quickly doubts were raised by right-wing tabloids and politicians about their age. In this article, I explore the arguments underpinning the Dubs campaign and the media coverage of the children’s arrival as a starting point for interrogating representational practices around children who seek asylum. I illustrate how the campaign was premised on a universal politics of childhood that inadvertently laid down the terms on which these children would be given protection, namely their innocence. The universality of childhood fuels public sympathy for child asylum-seekers, underlies the ‘child first, migrant second’ approach advocated by humanitarian organisations, and it was a key argument in the ‘Dubs amendment’. Yet the campaign highlights how representations of child asylum-seekers rely on codes that operate to identify ‘unchildlike’ children. As I show, in the context of the criminalisation of undocumented migrants‘, childhood is no longer a stable category which guarantees protection, but is subject to scrutiny and suspicion and can, ultimately, be disproved. KW - Politics of childhood KW - child asylum-seekers KW - innocence KW - humanitarianism; Y1 - 2017 U6 - https://doi.org/10.1080/1369183X.2017.1417027 SN - 1369-183X SN - 1469-9451 VL - 44 IS - 11 SP - 1757 EP - 1773 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Mardoukhi, Ahmad A1 - Mardoukhi, Yousof A1 - Hokka, Mikko A1 - Kuokkala, Veli-Tapani T1 - Effects of strain rate and surface cracks on the mechanical behaviour of Balmoral Red granite JF - Philosophical Transactions of the Royal Society of London, Series A : Mathematical, Physical and Engineering Sciences N2 - This work presents a systematic study on the effects of strain rate and surface cracks on the mechanical properties and behaviour of Balmoral Red granite. The tensile behaviour of the rock was studied at low and high strain rates using Brazilian disc samples. Heat shocks were used to produce samples with different amounts of surface cracks. The surface crack patterns were analysed using optical microscopy, and the complexity of the patterns was quantified by calculating the fractal dimensions of the patterns. The strength of the rock clearly drops as a function of increasing fractal dimensions in the studied strain rate range. However, the dynamic strength of the rock drops significantly faster than the quasi-static strength, and, because of this, also the strain rate sensitivity of the rock decreases with increasing fractal dimensions. This can be explained by the fracture behaviour and fragmentation during the dynamic loading, which is more strongly affected by the heat shock than the fragmentation at low strain rates. KW - split Hopkinson pressure bar KW - rock KW - granite KW - dynamic loading KW - fractal dimension KW - surface cracks Y1 - 2017 U6 - https://doi.org/10.1098/rsta.2016.0179 SN - 1364-503X SN - 1471-2962 VL - 375 IS - 2085 PB - Royal Society CY - London ER - TY - JOUR A1 - Radbruch, Moritz A1 - Pischon, Hannah A1 - Ostrowski, Anja A1 - Volz, Pierre A1 - Brodwolf, Robert A1 - Neumann, Falko A1 - Unbehauen, Michael A1 - Kleuser, Burkhard A1 - Haag, Rainer A1 - Ma, Nan A1 - Alexiev, Ulrike A1 - Mundhenk, Lars A1 - Gruber, Achim D. T1 - Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin JF - Nanoscale Research Letters N2 - Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e. g., to facilitate topical therapy in skin diseases. Atopic dermatitis is among the most common inflammatory skin disorders with complex barrier alterations which may affect the efficacy of topical treatment. Here, we tested the penetration behavior and identified target structures of unloaded CMS after topical administration in healthy mice and in mice with oxazolone-induced atopic dermatitis. We further examined whole body distribution and possible systemic side effects after simulating high dosage dermal penetration by subcutaneous injection. Following topical administration, CMS accumulated in the stratum corneum without penetration into deeper viable epidermal layers. The same was observed in atopic dermatitis mice, indicating that barrier alterations in atopic dermatitis had no influence on the penetration of CMS. Following subcutaneous injection, CMS were deposited in the regional lymph nodes as well as in liver, spleen, lung, and kidney. However, in vitro toxicity tests, clinical data, and morphometry-assisted histopathological analyses yielded no evidence of any toxic or otherwise adverse local or systemic effects of CMS, nor did they affect the severity or course of atopic dermatitis. Taken together, CMS accumulate in the stratum corneum in both healthy and inflammatory skin and appear to be highly biocompatible in the mouse even under conditions of atopic dermatitis and thus could potentially serve to create a depot for anti-inflammatory drugs in the skin. KW - CMS KW - Skin KW - Topical treatment KW - Dermal delivery KW - Atopic dermatitis KW - Oxazolone KW - Fluorescence lifetime imaging microscopy KW - Nanomaterials KW - Multi-domain nanoparticles KW - Penetration enhancement Y1 - 2017 U6 - https://doi.org/10.1186/s11671-017-1835-0 SN - 1556-276X VL - 12 IS - 64 PB - Springer CY - New York ER - TY - GEN A1 - Naolou, Toufik A1 - Rühl, Eckart A1 - Lendlein, Andreas T1 - Nanocarriers BT - Architecture, transport, and topical application of drugs for therapeutic use T2 - European Journal of Pharmaceutics and Biopharmaceutics Y1 - 2017 U6 - https://doi.org/10.1016/j.ejpb.2017.03.004 SN - 0939-6411 SN - 1873-3441 VL - 116 SP - 1 EP - 3 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ietswaart, Robert A1 - Rosa, Stefanie A1 - Wu, Zhe A1 - Dean, Caroline A1 - Howard, Martin T1 - Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation JF - Cell systems N2 - Single-cell quantification of transcription kinetics and variability promotes a mechanistic understanding of gene regulation. Here, using single-molecule RNA fluorescence in situ hybridization and mathematical modeling, we dissect cellular RNA dynamics for Arabidopsis FLOWERING LOCUS C (FLC). FLC expression quantitatively determines flowering time and is regulated by antisense (COOLAIR) transcription. In cells without observable COOLAIR expression, we quantify FLC transcription initiation, elongation, intron processing, and lariat degradation, as well as mRNA release from the locus and degradation. In these heterogeneously sized cells, FLC mRNA number increases linearly with cell size, resulting in a large cell-to-cell variability in transcript level. This variation is accounted for by cell-sizedependent, Poissonian FLC mRNA production, but not by large transcriptional bursts. In COOLAIRexpressing cells, however, antisense transcription increases with cell size and contributes to FLC transcription decreasing with cell size. Our analysis therefore reveals an unexpected role for antisense transcription in modulating the scaling of transcription with cell size. Y1 - 2017 U6 - https://doi.org/10.1016/j.cels.2017.05.010 SN - 2405-4712 SN - 2405-4720 VL - 4 SP - 622 EP - 635 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Estendorfer, Jennifer A1 - Stempfhuber, Barbara A1 - Haury, Paula A1 - Vestergaard, Gisle A1 - Rillig, Matthias C. A1 - Joshi, Jasmin Radha A1 - Schröder, Peter A1 - Schloter, Michael T1 - The Influence of Land Use Intensity on the Plant-Associated Microbiome of Dactylis glomerata L. JF - Frontiers in plant science N2 - In this study, we investigated the impact of different land use intensities (LUI) on the root-associated microbiome of Dactylis glomerata (orchardgrass). For this purpose, eight sampling sites with different land use intensity levels but comparable soil properties were selected in the southwest of Germany. Experimental plots covered land use levels from natural grassland up to intensively managed meadows. We used 16S rRNA gene based barcoding to assess the plant-associated community structure in the endosphere, rhizosphere and bulk soil of D. glomerata. Samples were taken at the reproductive stage of the plant in early summer. Our data indicated that roots harbor a distinct bacterial community, which clearly differed from the microbiome of the rhizosphere and bulk soil. Our results revealed Pseudomonadaceae, Enterobacteriaceae and Comamonadaceae as the most abundant endophytes independently of land use intensity. Rhizosphere and bulk soil were dominated also by Proteobacteria, but the most abundant families differed from those obtained from root samples. In the soil, the effect of land use intensity was more pronounced compared to root endophytes leading to a clearly distinct pattern of bacterial communities under different LUI from rhizosphere and bulk soil vs. endophytes. Overall, a change of community structure on the plant-soil interface was observed, as the number of shared OTUs between all three compartments investigated increased with decreasing land use intensity. Thus, our findings suggest a stronger interaction of the plant with its surrounding soil under low land use intensity. Furthermore, the amount and quality of available nitrogen was identified as a major driver for shifts in the microbiome structure in all compartments. KW - Dactylis glomerata KW - land use change KW - endophytes KW - rhizosphere KW - soil microbiome KW - biodiversity Y1 - 2017 U6 - https://doi.org/10.3389/fpls.2017.00930 SN - 1664-462X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Yarman, Aysu A1 - Jetzschmann, Katharina J. A1 - Neumann, Bettina A1 - Zhang, Xiaorong A1 - Wollenberger, Ulla A1 - Cordin, Aude A1 - Haupt, Karsten A1 - Scheller, Frieder W. T1 - Enzymes as Tools in MIP-Sensors JF - Chemosensors N2 - Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as tracers for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences. KW - enzymatic MIP synthesis KW - template digestion KW - enzyme tracer KW - enzymatic analyte conversion KW - molecularly imprinted polymers Y1 - 2017 U6 - https://doi.org/10.3390/chemosensors5020011 SN - 2227-9040 VL - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Thomas, Jessica E. A1 - Carvalho, Gary R. A1 - Haile, James A1 - Martin, Michael D. A1 - Castruita, Jose A. Samaniego A1 - Niemann, Jonas A1 - Sinding, Mikkel-Holger S. A1 - Sandoval-Velasco, Marcela A1 - Rawlence, Nicolas J. A1 - Fuller, Errol A1 - Fjeldsa, Jon A1 - Hofreiter, Michael A1 - Stewart, John R. A1 - Gilbert, M. Thomas P. A1 - Knapp, Michael T1 - An ‛Aukward’ tale BT - a genetic approach to discover the whereabouts of the Last Great Auks JF - Genes N2 - One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller’s candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars’ minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds. KW - ancient DNA KW - extinct birds KW - mitochondrial genome KW - museum specimens KW - palaeogenomics Y1 - 2017 U6 - https://doi.org/10.3390/genes8060164 SN - 2073-4425 VL - 8 IS - 6 SP - 164 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bendjeddou, Mohammed Lamine A1 - Loumassine, Hibat Allah A1 - Scheffler, Ingo A1 - Bouslama, Zihad A1 - Amr, Zuhair T1 - Bat ectoparasites (Nycteribiidae, Streblidae, Siphonaptera, Heteroptera, Mesostigmata, Argasidae, and Ixodidae) from Algeria JF - Journal of Vector Ecology N2 - Twenty two species of ectoparasites (Family Nycteribiidae: Nycteribia (Listropoda) schmidlii schmidlii, Nycteribia (Nycteribia) latreillii, Nycteribia (Nycteribia) pedicularia, Penicillidia (Penicillidia) dufourii, and Phthiridium biarticulatum; Family Streblidae: Brachytarsina (Brachytarsina) flavipennis and Raymondia huberi; Order Siphonaptera: Rhinolophopsylla unipectinata arabs, Nycteridopsylla longiceps, Araeopsylla gestroi, Ischnopsyllus intermedius, and Ischnopsyllus octactenus; Order Heteroptera: Cimex pipistrelli, Cimex lectularius, and Cacodmus vicinus; Class Arachnida: Order Mesostigmata: Spinturnix myoti and Eyndhovenia euryalis; Order Ixodida: Family Argasidae: Argas transgariepinus and Argas vespertilionis; Family Ixodidae: Hyalomma dromedarii, Ixodes ricinus, and Ixodes vespertilionis) were recovered from 19 bat species in Algeria. New host records for bats are recorded for the first time: N. schmidlii from Rh. clivosus and R. cystops; N. latreillii from Rh. blasii and P. gaisleri; R. huberi from Rh. clivosus; C. pipistrelli from E. isabellinus and H. savii; C. vicinus from E. isabellinus; S. myoti from P. gaisleri; E. euryalis from P. gaisleri and Rh. blasii; A. vespertilionis from P. gaisleri; I. ricinus from T. teniotis and Rh. hipposideros and H. dromedarii from P. kuhlii. Raymondia huberi is recorded for the first time from Algeria. KW - Bats KW - Nycteribiidae KW - Streblidae KW - Siphonaptera KW - Heteroptera KW - Mesostigmata KW - Argasidae KW - Ixodidae KW - Algeria Y1 - 2017 U6 - https://doi.org/10.1111/jvec.12235 SN - 1948-7134 VL - 42 SP - 13 EP - 23 PB - Wiley Interscience CY - Hoboken, NJ ER - TY - JOUR A1 - Schulz-Behrendt, Claudia A1 - Salzwedel, Annett A1 - Rabe, Sophie A1 - Ortmann, K. A1 - Völler, Heinz T1 - Aspekte beruflicher und sozialer Wiedereingliederung aus Sicht kardiovaskulär erkrankter Rehabilitanden in besonderen beruflichen Problemlagen T1 - Subjective Aspects of Return to Work and Social Reintegration in Patients with Extensive Work-related Problems in Cardiac Rehabilitation BT - Ergebnisse einer qualitativen Erhebung BT - Results of a Qualitative Investigation JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Ziel: Untersucht wurden subjektive bio-psycho-soziale Auswirkungen chronischer Herz- und Gefäßerkrankungen, Bewältigungsstrategien und Formen sozialer Unterstützung bei Rehabilitanden in besonderen beruflichen Problemlagen (BBPL). Methodik: Für die qualitative Untersuchung wurden 17 Patienten (48,9±7,0 Jahre, 13 männl.) mit BBPL (SIMBO-C>30) in leitfadengestützten Interviews befragt. Die Auswertung erfolgte softwaregestützt nach dem inhaltsanalytischen Ansatz von Mayring. Ergebnisse: Im Rahmen der Krankheitsauswirkungen benannten die Patienten soziale, einschließlich beruflicher Aspekte mit 62% der Aussagen deutlich häufiger als physische oder psychische Faktoren (9 bzw. 29%). Angewandte Bewältigungsstrategien und erfahrene Unterstützungsleistungen richteten sich jedoch überwiegend auf körperliche Einschränkungen (70 bzw. 45%). Schlussfolgerung: Obgleich soziale Krankheitsauswirkungen für die befragten Rehabilitanden subjektiv bedeutsam waren, gelang die Entwicklung geeigneter Bewältigungsstrategien nur unzureichen N2 - Objective This study investigated subjective biopsychosocial effects of coronary heart disease (CHD), coping strategies and social support in patients undergoing cardiac rehabilitation (CR) and having extensive work-related problems. Methods A qualitative investigation was performed in 17 patients (48.9 +/- 7.0 y, 13 male) with extensive work-related problems (SIMBO-C > 30). All patients were interviewed with structured surveys. Data analysis was performed using a software that is based on the content analysis approach of Mayring. Results In regard to effects of disease, patients indicated social aspects including occupational aspects (62 %) more often than physical or mental factors (9 or 29 %). Applied coping strategies and support services are mainly focused on physical impairments (70 or 45 %). Conclusions The development of appropriate coping strategies was insufficient although social effects of disease were subjectively meaningful for patients in CR. KW - cardiac rehabilitation KW - extensive work-related problems KW - social support KW - return to work KW - kardiologische Rehabilitation KW - besondere berufliche Problemlagen KW - soziale Unterstützung KW - berufliche Wiedereingliederung Y1 - 2017 U6 - https://doi.org/10.1055/s-0042-121379 SN - 0034-3536 SN - 1439-1309 VL - 56 IS - 3 SP - 181 EP - 188 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - von Aster, Michael G. T1 - Dyskalkulie T1 - Dyscalculia BT - wenn Kinder nicht rechnen lernen BT - if children do not learn arithmetics JF - Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde N2 - Hintergrund Ausgeprägte Schwierigkeiten beim Erwerb der grundlegenden arithmetischen Fertigkeiten bei ansonsten durchschnittlichen Schulleistungen werden als Rechenstörung oder Dyskalkulie bezeichnet. Davon betroffen sind etwa 5 % der Grundschülerpopulation. Die Ursachen und die Symptome sind ebenso vielgestaltig wie die Methoden der differenziellen Förderung und Therapie. Material und Methode Selektive Literaturrecherche zur Rechenstörung aus verschiedenen mit dem Gegenstand befassten wissenschaftlichen Disziplinen. Ergebnisse Der Erwerb von Fähigkeiten zur Zahlenverarbeitung und zum Rechnen wird als ein erfahrungsabhängiger neuroplastischer Reifungsprozess verstanden, der zu einem komplexen, spezialisierten neuronalen Netzwerk führt und verschiedene kognitive Zahlenrepräsentationen hervorbringt. Die Entwicklung dieser domänenspezifischen Fähigkeiten ist abhängig von der Entwicklung domänenübergreifender Fähigkeiten, wie Aufmerksamkeit, Arbeitsgedächtnis, Sprache und visuell-räumlichen Fähigkeiten. Störungen dieser Reifungsprozesse können in verschiedenen Entwicklungsstadien unterschiedliche Komponenten der Entwicklung dieses komplexen kognitiven Systems betreffen und sind daher im klinischen Erscheinungsbild vielgestaltig. Sonderpädagogische, lerntherapeutische und ggf. medizinische Maßnahmen benötigen eine differenzielle Diagnostik und Indikationsstellung. Moderne computerbasierte Lernsoftware kann sowohl die schulische Didaktik als auch lerntherapeutische Vorgehensweisen unterstützen. Schlussfolgerung Frühzeitiges Erkennen sowie differenzielle und individualisierte Förderung können die Gefahr des Auftretens sekundärer emotionaler Störungen mindern. Die Diagnostik und die Behandlung der Rechenstörung sollten evidenzbasiert und leitlinienorientiert erfolgen sowie der Komplexität und Vielgestaltigkeit der Symptombildungen Rechnung tragen. N2 - Background Dyscalculia is defined as severe difficulties in acquiring basic arithmetic competencies in children with otherwise average scholastic performance. About 5% of children in the population of primary school children are affected. The etiological factors and clinical symptoms are as multifarious as the methods of differential treatment and therapy. Materials and methods Selective review of publications regarding dyscalculia from multiple disciplines addressing the subject. Results The acquisition of abilities in number processing and arithmetic skills is conceptualized as an experience-based neuroplastic developmental process leading to a complex, specialised neuronal network and different cognitive representations of numbers. The development of these domain-specific abilities depends on the development of domain-general abilities such as attention, working memory and visuospatial abilities. Troubles in these maturational processes can lead to deficits in various components of this complex system resulting into heterogeneous symptoms. Special need interventions and therapy as well as possible medical approaches require a holistic diagnostic assessment and differential indication. Modern computer-based learning software can support learning processes in special need interventions. Conclusion Early identification as well as differential and individualised intervention can reduce the risk of the developing secondary psychiatric disorders. The diagnosis and treatment of dyscalculia should be made using evidence-based procedures following the guidelines which take account of the complexity of dyscalculia and its varying cognitive functional profile. KW - Mathematics KW - Dyscalculia KW - Comorbidity KW - Performance anxiety KW - Learning therapy Y1 - 2017 U6 - https://doi.org/10.1007/s00112-017-0289-x SN - 0026-9298 SN - 1433-0474 VL - 165 SP - 482 EP - 489 PB - Springer CY - New York ER -