TY  - JOUR
A1  - Herter, Susanne
A1  - McKenna, Shane M.
A1  - Frazer, Andrew R.
A1  - Leimkühler, Silke
A1  - Carnell, Andrew J.
A1  - Turner, Nicholas J.
T1  - Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis
JF  - ChemCatChem : heterogeneous & homogeneous & bio- & nano-catalysis ; a journal of ChemPubSoc Europe
N2  - The use of selected engineered galactose oxidase (GOase) variants for the oxidation of amino alcohols to aldehydes under mild conditions in aqueous systems is reported. GOase variant F-2 catalyses the regioselective oxidation of N-carbobenzyloxy (Cbz)-protected 3-amino-1,2-propanediol to the corresponding -hydroxyaldehyde which was then used in an aldolase reaction. Another variant, M3-5, was found to exhibit activity towards free and N-Cbz-protected aliphatic and aromatic amino alcohols allowing the synthesis of lactams such as 3,4-dihydronaphthalen-1(2H)-one, 2-pyrrolidone and valerolactam in one-pot tandem reactions with xanthine dehydrogenase (XDH) or aldehyde oxidase (PaoABC).
KW  - aldehyde oxidase
KW  - amino alcohols
KW  - cascade reactions
KW  - enzyme catalysis
KW  - lactams
Y1  - 2015
U6  - https://doi.org/10.1002/cctc.201500218
SN  - 1867-3880
SN  - 1867-3899
VL  - 7
IS  - 15
SP  - 2313
EP  - 2317
PB  - Wiley-VCH
CY  - Weinheim
ER  -