TY - JOUR A1 - Grimbs, Sergio A1 - Arnold, Anne A1 - Koseska, Aneta A1 - Kurths, Jürgen A1 - Selbig, Joachim A1 - Nikoloski, Zoran T1 - Spatiotemporal dynamics of the Calvin cycle multistationarity and symmetry breaking instabilities JF - Biosystems : journal of biological and information processing sciences N2 - The possibility of controlling the Calvin cycle has paramount implications for increasing the production of biomass. Multistationarity, as a dynamical feature of systems, is the first obvious candidate whose control could find biotechnological applications. Here we set out to resolve the debate on the multistationarity of the Calvin cycle. Unlike the existing simulation-based studies, our approach is based on a sound mathematical framework, chemical reaction network theory and algebraic geometry, which results in provable results for the investigated model of the Calvin cycle in which we embed a hierarchy of realistic kinetic laws. Our theoretical findings demonstrate that there is a possibility for multistationarity resulting from two sources, homogeneous and inhomogeneous instabilities, which partially settle the debate on multistability of the Calvin cycle. In addition, our tractable analytical treatment of the bifurcation parameters can be employed in the design of validation experiments. KW - Multistationarity KW - Calvin cycle KW - Algebraic geometry KW - Bifurcation parameters KW - Biomass Y1 - 2011 U6 - https://doi.org/10.1016/j.biosystems.2010.10.015 SN - 0303-2647 VL - 103 IS - 2 SP - 212 EP - 223 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Anishchenko, Vadim S. A1 - Vadivasova, T. E. A1 - Kopeikin, A. S. A1 - Strelkova, G. I. A1 - Kurths, Jürgen T1 - Spectral and correlation analysis of spiral chaos N2 - We study numerically the behavior of the autocorrelation function (ACF) and the power spectrum of spiral attractors without and in the presence of noise. It is shown that the ACF decays exponentially and has two different time scales. The rate of the ACF decrease is defined by the amplitude fluctuations on small time intervals, i.e., when tau < tau(cor), and by the effective diffusion coefficient of the instantantaneous phase on large time intervals. it is also demonstrated that the ACF in the Poincare map also decreases according to the exponential law exp(-lambda(+)k), where lambda(+) is the positive Lyapunov exponent. The obtained results are compared with the theory of fluctuations for the Van der Pol oscillator Y1 - 2003 SN - 0219-4775 ER - TY - JOUR A1 - Fujiwara, Naoya A1 - Kurths, Jürgen T1 - Spectral universality of phase synchronization in non-identical oscillator networks N2 - We employ a spectral decomposition method to analyze synchronization of a non-identical oscillator network. We study the case that a small parameter mismatch of oscillators is characterized by one parameter and phase synchronization is observed. We derive a linearized equation for each eigenmode of the coupling matrix. The parameter mismatch is reflected on inhomogeneous term in the linearized equation. We find that the oscillation of each mode is essentially characterized only by the eigenvalue of the coupling matrix with a suitable normalization. We refer to this property as spectral universality, because it is observed irrespective of network topology. Numerical results in various network topologies show good agreement with those based on linearized equation. This universality is also observed in a system driven by additive independent Gaussian noise. Y1 - 2009 UR - http://www.springerlink.com/content/101159 U6 - https://doi.org/10.1140/epjb/e2009-00078-6 SN - 1434-6028 ER - TY - JOUR A1 - Thiel, Marco A1 - Romano, Maria Carmen A1 - Kurths, Jürgen T1 - Spurious structures in recurrence plots induced by embedding N2 - In this paper we show that delay embedding produces spurious structures in a recurrence plot (RP) that are not present in the real attractor. We analyze typical sets of simulated data, such as white noise and data from the chaotic Rossler system to show the relevance of this effect. In the second part of the paper we show that the second order Renyi entropy and the correlation dimension are dynamical invariants that can be estimated from Recurrence Plots with arbitrary embedding dimension and delay Y1 - 2006 U6 - https://doi.org/10.1007/s11071-006-2010-9 ER - TY - JOUR A1 - Kuznetsov, A. S. A1 - Kurths, Jürgen T1 - Stable heteroclinic cycles for ensembles of chaotic oscillators Y1 - 2002 ER - TY - JOUR A1 - Zakharova, Anna A1 - Vadivasova, Tatjana A1 - Anishchenko, Vadim S. A1 - Koseska, Aneta A1 - Kurths, Jürgen T1 - Stochastic bifurcations and coherencelike resonance in a self-sustained bistable noisy oscillator N2 - We investigate the influence of additive Gaussian white noise on two different bistable self-sustained oscillators: Duffing-Van der Pol oscillator with hard excitation and a model of a synthetic genetic oscillator. In the deterministic case, both oscillators are characterized with a coexistence of a stable limit cycle and a stable equilibrium state. We find that under the influence of noise, their dynamics can be well characterized through the concept of stochastic bifurcation, consisting in a qualitative change of the stationary amplitude distribution. For the Duffing-Van der Pol oscillator analytical results, obtained for a quasiharmonic approach, are compared with the result of direct computer simulations. In particular, we show that the dynamics is different for isochronous and anisochronous systems. Moreover, we find that the increase of noise intensity in the isochronous regime leads to a narrowing of the spectral line. This effect is similar to coherence resonance. However, in the case of anisochronous systems, this effect breaks down and a new phenomenon, anisochronous-based stochastic bifurcation occurs. Y1 - 2010 UR - http://pre.aps.org/ U6 - https://doi.org/10.1103/Physreve.81.011106 SN - 1539-3755 ER - TY - JOUR A1 - Spahn, Frank A1 - Krivov, Alexander V. A1 - Sremcevic, Miodrag A1 - Schwarz, U. A1 - Kurths, Jürgen T1 - Stochastic forces in circumplanetary dust dynamics N2 - Charged dust grains in circumplanetary environments experience, beyond various deterministic forces, also stochastic perturbations caused, by fluctuations of the magnetic field, the charge of the grains, by chaotic rotation of aspherical grains, etc. Here we investigate the dynamics of a dust population in a circular orbit around a planet which is perturbed by a stochastic planetary magnetic field B', modeled by an isotropically Gaussian white noise. The resulting perturbation equations give rise to a modified diffusion of the inclinations i and eccentricities e. The diffusion coefficient is found to be D proportional to w^2 O /n^2 , where the gyrofrequency, the Kepler frequency, and the synodic frequency are denoted by w , O, and n, respectively. This behavior has been checked against numerical simulations. We have chosen dust grains (1 m in radius) ejected from Jupiter's satellite Europa in circular equatorial orbits around Jupiter and integrated numerically their trajectories over their typical lifetimes (100 years). The particles were exposed to a Gaussian fluctuating magnetic field B' with the same statistical properties as in the analytical treatment. These simulations have confirmed the analytical results. The theoretical studies showed the statistical properties of B' to be of decisive importance. To estimate them, we analyzed the magnetic field data obtained by the Galileo spacecraft magnetometer at Jupiter and found almost Gaussian fluctuations of about 5% of the mean field and exponentially decaying correlations. This results in a diffusion of orbital inclinations and eccentricities of the dust grains of about ten percent over the lifetime of the particles. For smaller dusty motes or for close-in particles (e.g., in Jovian gossamer rings) stochastics might well dominate the dynamics. Y1 - 2003 UR - http://www.agu.org/pubs/current/je/ ER - TY - JOUR A1 - Volkov, E. I. A1 - Ullner, Ekkehard A1 - Kurths, Jürgen T1 - Stochastic multiresonance in the coupled relaxation oscillators N2 - We study the noise-dependent dynamics in a chain of four very stiff excitable oscillators of the FitzHugh- Nagumo type locally coupled by inhibitor diffusion. We could demonstrate frequency- and noise-selective signal acceptance which is based on several noise-supported stochastic attractors that arise owing to slow variable diffusion between identical excitable elements. The attractors have different average periods distinct from that of an isolated oscillator and various phase relations between the elements. We explain the correspondence between the noise-supported stochastic attractors and the observed resonance peaks in the curves for the linear response versus signal frequency. (C) 2005 American Institute of Physics Y1 - 2005 SN - 1054-1500 ER - TY - JOUR A1 - Zemanova, Lucia A1 - Zhou, Changsong A1 - Kurths, Jürgen T1 - Structural and functional clusters of complex brain networks JF - Physica, D, Nonlinear phenomena N2 - Recent research using the complex network approach has revealed a rich and complicated network topology in the cortical connectivity of mammalian brains. It is of importance to understand the implications of such complex network structures in the functional organization of the brain activities. Here we study this problem from the viewpoint of dynamical complex networks. We investigate synchronization dynamics on the corticocortical network of the cat by modeling each node (cortical area) of the network with a sub-network of interacting excitable neurons. We find that the network displays clustered synchronization behavior, and the dynamical clusters coincide with the topological community structures observed in the anatomical network. Our results provide insights into the relationship between the global organization and the functional specialization of the brain cortex. KW - cortical network KW - anatomical connectivity KW - functional connectivity KW - topological community KW - dynamical cluster Y1 - 2006 U6 - https://doi.org/10.1016/j.physd.2006.09.008 SN - 0167-2789 SN - 1872-8022 VL - 224 IS - 1-2 SP - 202 EP - 212 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Anishchenko, Vadim S. A1 - Kopeikin, A. S. A1 - Kurths, Jürgen T1 - Studying hyperbolicity in chaotic systems Y1 - 2000 ER - TY - JOUR A1 - Thiel, M. A1 - Romano, Maria Carmen A1 - Schwarz, Udo A1 - Kurths, Jürgen A1 - Timmer, Jens T1 - Surrogate-based hypothesis test without surrogates N2 - Fourier surrogate data are artificially generated time series, that - based on a resampling scheme - share the linear properties with an observed time series. In this paper we study a statistical surrogate hypothesis test to detect deviations from a linear Gaussian process with respect to asymmetry in time (Q-statistic). We apply this test to a Fourier representable function and obtain a representation of the asymmetry in time of the sample data, a characteristic for nonlinear processes, and the significance in terms of the Fourier coefficients. The main outcome is that we calculate the expected value of the mean and the standard deviation of the asymmetries of the surrogate data analytically and hence, no surrogates have to be generated. To illustrate the results we apply our method to the saw tooth function, the Lorenz system and to measured X-ray data of Cygnus X-1 Y1 - 2004 SN - 0218-1274 ER - TY - JOUR A1 - Zaks, Michael A. A1 - Pikovskij, Arkadij A1 - Kurths, Jürgen T1 - Symbolic dynamics behind the singular continuous power spectra of continuous flows Y1 - 1998 ER - TY - JOUR A1 - Wessel, Niels A1 - Schwarz, Udo A1 - Saparin, Peter A1 - Kurths, Jürgen T1 - Symbolic dynamics for medical data analysis N2 - Observational data of natural systems, as measured in medical measurements are typically quite different from those obtained in laboratories. Due to the peculiarities of these data, wellknown characteristics, such as power spectra or fractal dimension, often do not provide a suitable description. To study such data, we present here some measures of complexity, which are basing on symbolic dynamics. Firstly, a motivation for using symbolic dynamics and measures of complexity in data analysis based on the logistic map is given and next, two applications to medical data are shown. We demonstrate that symbolic dynamics is a useful tool for the risk assessment of patients after myocardial infarction as well as for the evaluation of th e architecture of human cancellous bone. Y1 - 2002 UR - http://www.agnld.uni-potsdam.de/~shw/Paper/EUROATTRACTOR2000.ps SN - 3-936142-09-2 ER - TY - JOUR A1 - Engbert, Ralf A1 - Scheffczyk, Christian A1 - Krampe, Ralf-Thomas A1 - Kurths, Jürgen A1 - Kliegl, Reinhold T1 - Symbolic dynamics of bimanual production of polyrhythms N2 - We analyse time series from a study on bimanual rhythmic movements in which the speed of performance (the external control parameter) was experimentally manipulated. Using symbolic transformations as a visualization technique we observe qualitative changes in the dynamics of the timing patterns. Such phase transitions are quantitatively described by measures of complexity. Using these results we develop an advanced symbolic coding which enables us to detect important dynamical structures. Furthermore, our analysis raises new questions concerning the modelling of the underlying human cognitive-motor system. Y1 - 2002 SN - 3-540- 63481-9 ER - TY - JOUR A1 - Beim Graben, Peter A1 - Saddy, Douglas A1 - Schlesewsky, Matthias A1 - Kurths, Jürgen T1 - Symbolic dynamics of event-related brain potentials Y1 - 2000 ER - TY - JOUR A1 - Schiek, Michael A1 - Scheffczyk, Christian A1 - Engbert, Ralf A1 - Kurths, Jürgen A1 - Krampe, Ralf-Thomas A1 - Kliegl, Reinhold A1 - Drepper, Friedhelm R. T1 - Symbolic dynamics of physiological synchronisation : examples from bimanual movements and cardiorespiratory interaction N2 - Key words: Nonlinear time series analysis, symbolic dynamics, phase transitions, physiological data, biological synchronization, production of polyrhythms, cardiorespiratory interaction, variation of control parameter Y1 - 1997 ER - TY - BOOK A1 - Osipov, Grigory V. A1 - Kurths, Jürgen A1 - Zhou, Changsong T1 - Synchronisation in Oscillatory Networks Y1 - 2007 SN - 978-3-540-71268-8 PB - Springer-Verlag CY - Berlin ER - TY - BOOK A1 - Pikovskij, Arkadij A1 - Rosenblum, Michael A1 - Kurths, Jürgen T1 - Synchronization : a universal concept in nonlinear sciences T3 - Cambridge nonlinear science series Y1 - 2001 SN - 0-521-59285-2 VL - 12 PB - Cambridge Univ. Press CY - Cambridge ET - 1st paperback ed., repr ER - TY - JOUR A1 - Romano, Maria Carmen A1 - Thiel, Marco A1 - Kurths, Jürgen A1 - Rolfs, Martin A1 - Engbert, Ralf A1 - Kliegl, Reinhold T1 - Synchronization Analysis and Recurrence in Complex Systems Y1 - 2006 SN - 978-3-527-40623-4 ER - TY - JOUR A1 - Kurths, Jürgen A1 - Romano, Maria Carmen A1 - Thiel, Marco A1 - Osipov, Grigory V. A1 - Ivanchenko, Mikhail V. A1 - Kiss, Istvan Z. A1 - Hudson, John L. T1 - Synchronization analysis of coupled noncoherent oscillators N2 - We present two different approaches to detect and quantify phase synchronization in the case of coupled non- phase coherent oscillators. The first one is based on the general idea of curvature of an arbitrary curve. The second one is based on recurrences of the trajectory in phase space. We illustrate both methods in the paradigmatic example of the Rossler system in the funnel regime. We show that the second method is applicable even in the case of noisy data. Furthermore, we extend the second approach to the application of chains of coupled systems, which allows us to detect easily clusters of synchronized oscillators. In order to illustrate the applicability of this approach, we show the results of the algorithm applied to experimental data from a population of 64 electrochemical oscillators Y1 - 2006 UR - http://www.springerlink.com/content/102972 U6 - https://doi.org/10.1007/s11071-006-1957-x SN - 0924-090X ER - TY - JOUR A1 - Rosenblum, Michael A1 - Pikovskij, Arkadij A1 - Kurths, Jürgen T1 - Synchronization approach to analysis of biological systems N2 - In this article we review the application of the synchronization theory to the analysis of multivariate biological signals. We address the problem of phase estimation from data and detection and quantification of weak interaction, as well as quantification of the direction of coupling. We discuss the potentials as well as limitations and misinterpretations of the approach Y1 - 2004 SN - 0219-4775 ER - TY - JOUR A1 - Boccaletti, Stefano A1 - Hwang, Dong-Uk A1 - Chavez, Mario A1 - Amann, Andreas A1 - Kurths, Jürgen A1 - Pecora, Louis M. T1 - Synchronization in dynamical networks : evolution along commutative graphs N2 - Starting from an initial wiring of connections, we show that the synchronizability of a network can be significantly improved by evolving the graph along a time dependent connectivity matrix. We consider the case of connectivity matrices that commute at all times, and compare several approaches to engineer the corresponding commutative graphs. In particular, we show that synchronization in a dynamical network can be achieved even in the case in which each individual commutative graphs does not give rise to synchronized behavior Y1 - 2006 UR - http://pre.aps.org/ U6 - https://doi.org/10.1103/Physreve.74.016102 SN - 1539-3755 ER - TY - JOUR A1 - Rosenblum, Michael A1 - Kurths, Jürgen A1 - Pikovskij, Arkadij A1 - Schafer, C. A1 - Tass, Peter A1 - Abel, Hans-Henning T1 - Synchronization in Noisy Systems and Cardiorespiratory Interaction Y1 - 1998 ER - TY - JOUR A1 - Rosenblum, Michael A1 - Abel, Hans-Henning A1 - Kurths, Jürgen A1 - Schäfer, Carsten T1 - Synchronization in the human cardiorespiratory system Y1 - 1999 ER - TY - JOUR A1 - Huang, Tingwen A1 - Chen, Guanrong A1 - Kurths, Jürgen T1 - Synchronization of chaotic of chaotic systems with time-varying coupöing delays JF - Discrete and continuous dynamical systems : a journal bridging mathematics and sciences ; Series B, Mathematical modelling, analysis and computations N2 - In this paper, we study the complete synchronization of a class of time-varying delayed coupled chaotic systems using feedback control. In terms of Linear Matrix Inequalities, a sufficient condition is obtained through using a Lyapunov-Krasovskii functional and differential equation in equalities. The conditions can be easily verified and implemented. We present two simulation examples to illustrate the effectiveness of the proposed method. KW - Synchronization KW - Chaotic System KW - Time-varying Delay Y1 - 2011 U6 - https://doi.org/10.3934/dcdsb.2011.16.1071 SN - 1531-3492 VL - 16 IS - 4 SP - 1071 EP - 1082 PB - American Institute of Mathematical Sciences CY - Springfield ER - TY - JOUR A1 - Boccaletti, Stefano A1 - Valladares, D. L. A1 - Kurths, Jürgen T1 - Synchronization of chaotic structurally nonequivalent systems Y1 - 2000 ER - TY - JOUR A1 - Li, Changpin A1 - Sun, Weigang A1 - Kurths, Jürgen T1 - Synchronization of complex dynamical networks with time delays N2 - In the present paper, two kinds of dynamical complex networks are considered. The first is that elements of every node have different time delays but all nodes in Such networks have the same time-delay vector. The second is that different nodes have different time-delay vectors, and the elements of each node also have different time delays. Corresponding synchronization theorems are established. Numerical examples show the efficiency of the derived theorems. Y1 - 2006 UR - http://www.sciencedirect.com/science/journal/03784371 U6 - https://doi.org/10.1016/j.physa.2005.07.007 SN - 0378-4371 ER - TY - JOUR A1 - Meucci, Riccardo A1 - Salvadori, Francesco A1 - Ivanchenko, Mikhail V. A1 - Al Naimee, Kais A1 - Zhou, Chansong A1 - Arecchi, Fortunato Tito A1 - Boccaletti, Stefano A1 - Kurths, Jürgen T1 - Synchronization of spontaneous bursting in a CO2 laser JF - Physical review : E, Statistical, nonlinear and soft matter physics N2 - We present experimental and numerical evidence of synchronization of burst events in two different modulated CO2 lasers. Bursts appear randomly in each laser as trains of large amplitude spikes intercalated by a small amplitude chaotic regime. Experimental data and model show the frequency locking of bursts in a suitable interval of coupling strength. We explain the mechanism of this phenomenon and demonstrate the inhibitory properties of the implemented coupling. Y1 - 2006 U6 - https://doi.org/10.1103/PhysRevE.74.066207 SN - 2470-0045 SN - 2470-0053 VL - 74 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Montbrio, Ernest A1 - Kurths, Jürgen A1 - Blasius, Bernd T1 - Synchronization of two interacting populations of oscillators N2 - We analyze synchronization between two interacting populations of different phase oscillators. For the important case of asymmetric coupling functions, we find a much richer dynamical behavior compared to that of symmetrically coupled populations of identical oscillators. It includes three types of bistabilities, higher order entrainment and the existence of states with unusual stability properties. All possible routes to synchronization of the populations are presented and some stability boundaries are obtained analytically. The impact of these findings for neuroscience is discussed. Y1 - 2004 UR - http://www.agnld.uni-potsdam.de/~bernd/papers/pre3.pdf ER - TY - JOUR A1 - Ivanchenko, Mikhail V. A1 - Osipov, Grigory V. A1 - Shalfeev, V. D. A1 - Kurths, Jürgen T1 - Synchronization of two non-scalar-coupled limit-cycle oscillators N2 - Being one of the fundamental phenomena in nonlinear science, synchronization of oscillations has permanently remained an object of intensive research. Development of many asymptotic methods and numerical simulations has allowed an understanding and explanation of various phenomena of self-synchronization. But even in the classical case of coupled van der Pol oscillators a full description of all possible dynamical regimes, their mutual transitions and characteristics is still lacking. We present here a study of the phenomenon of mutual synchronization for two non-scalar- coupled non-identical limit-cycle oscillators and analyze phase, frequency and amplitude characteristics of synchronization regimes. A series of bifurcation diagrams that we obtain exhibit various regions of qualitatively different behavior. Among them we find mono-, bi- and multistability regions, beating and "oscillation death" ones; also a region, where one of the oscillators dominates the other one is observed. The frequency characteristics that we obtain reveal three qualitatively different types of synchronization: (i) on the mean frequency (the in-phase synchronization), (ii) with a shift from the mean frequency caused by a conservative coupling term (the anti-phase synchronization), and (iii) on the frequency of one of the oscillators (when one oscillator dominates the other). (C) 2003 Elsevier B.V. All rights reserved Y1 - 2004 ER - TY - JOUR A1 - Srinivasan, K. A1 - Senthilkumar, Dharmapuri Vijayan A1 - Murali, K. A1 - Lakshmanan, Muthusamy A1 - Kurths, Jürgen T1 - Synchronization transitions in coupled time-delay electronic circuits with a threshold nonlinearity JF - Chaos : an interdisciplinary journal of nonlinear science N2 - Experimental observations of typical kinds of synchronization transitions are reported in unidirectionally coupled time-delay electronic circuits with a threshold nonlinearity and two time delays, namely feedback delay tau(1) and coupling delay tau(2). We have observed transitions from anticipatory to lag via complete synchronization and their inverse counterparts with excitatory and inhibitory couplings, respectively, as a function of the coupling delay tau(2). The anticipating and lag times depend on the difference between the feedback and the coupling delays. A single stability condition for all the different types of synchronization is found to be valid as the stability condition is independent of both the delays. Further, the existence of different kinds of synchronizations observed experimentally is corroborated by numerical simulations and from the changes in the Lyapunov exponents of the coupled time-delay systems. Y1 - 2011 U6 - https://doi.org/10.1063/1.3591791 SN - 1054-1500 VL - 21 IS - 2 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Osipov, Grigory V. A1 - Ivanchenko, Mikhail V. A1 - Kurths, Jürgen A1 - Hu, B. T1 - Synchronized chaotic intermittent and spiking behavior in coupled map chains N2 - We study phase synchronization effects in a chain of nonidentical chaotic oscillators with a type-I intermittent behavior. Two types of parameter distribution, linear and random, are considered. The typical phenomena are the onset and existence of global (all-to-all) and cluster (partial) synchronization with increase of coupling. Increase of coupling strength can also lead to desynchronization phenomena, i.e., global or cluster synchronization is changed into a regime where synchronization is intermittent with incoherent states. Then a regime of a fully incoherent nonsynchronous state (spatiotemporal intermittency) appears. Synchronization-desynchronization transitions with increase of coupling are also demonstrated for a system resembling an intermittent one: a chain of coupled maps replicating the spiking behavior of neurobiological networks Y1 - 2005 SN - 1539-3755 ER - TY - JOUR A1 - Kitajima, H. A1 - Kurths, Jürgen T1 - Synchronized firing of FitzHugh-Nagumo neurons by noise N2 - We investigate the influence of noise on synchronization between the spiking activities of neurons with external impulsive forces. We first analyze the dependence of the synchronized firing on the amplitude and the angular frequency of the impulsive force in the noise-free system. Three cases (regular spiking, traveling wave, and chaotic spiking) with low synchronized firing are chosen to study effects due to noise. In each case we find that small noise can be a promoter of synchronization phenomena in neural activities, by choosing an appropriate noise intensity acting on some of the neurons. (C) 2005 American Institute of Physics Y1 - 2005 SN - 1054-1500 ER - TY - JOUR A1 - Koseska, Aneta A1 - Volkov, Evgenii A1 - Kurths, Jürgen T1 - Synthetic multicellular oscillatory systems controlling protein dynamics with genetic circuits JF - Physica scripta : an international journal for experimental and theoretical physics N2 - Synthetic biology is a relatively new research discipline that combines standard biology approaches with the constructive nature of engineering. Thus, recent efforts in the field of synthetic biology have given a perspective to consider cells as 'programmable matter'. Here, we address the possibility of using synthetic circuits to control protein dynamics. In particular, we show how intercellular communication and stochasticity can be used to manipulate the dynamical behavior of a population of coupled synthetic units and, in this manner, finely tune the expression of specific proteins of interest, e.g. in large bioreactors. Y1 - 2011 U6 - https://doi.org/10.1088/0031-8949/84/04/045007 SN - 0031-8949 VL - 84 IS - 4 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Scheffczyk, Christian A1 - Krampe, Ralf-Thomas A1 - Engbert, Ralf A1 - Rosenblum, Michael A1 - Kurths, Jürgen A1 - Kliegl, Reinhold T1 - Tempo-induced transitions in polyrhythmic hand movements N2 - We investigate the cognitive control in polyrhythmic hand movements as a model paradigm for bimanual coordination. Using a symbolic coding of the recorded time series, we demonstrate the existence of qualitative transitions induced by experimental manipulation of the tempo. A nonlinear model with delayed feedback control is proposed, which accounts for these dynamical transitions in terms of bifurcations resulting from variation of the external control parameter. Furthermore, it is shown that transitions can also be observed due to fluctuations in the timing control level. We conclude that the complexity of coordinated bimanual movements results from interactions between nonlinear control mechanisms with delayed feedback and stochastic timing components. Y1 - 1997 ER - TY - JOUR A1 - Voss, Henning U. A1 - Kurths, Jürgen T1 - Test for nonlinear dynamical behavior in symbol sequences Y1 - 1998 ER - TY - JOUR A1 - Riedl, Maik A1 - van Leeuwen, Peter Jan A1 - Suhrbier, Alexander A1 - Malberg, Hagen A1 - Groenemeyer, Dietrich A1 - Kurths, Jürgen A1 - Wessel, Niels T1 - Testing foetal-maternal heart rate synchronization via model-based analyses N2 - The investigation of foetal reaction to internal and external conditions and stimuli is an important tool in the characterization of the developing neural integration of the foetus. An interesting example of this is the study of the interrelationship between the foetal and the maternal heart rate. Recent studies have shown a certain likelihood of occasional heart rate synchronization between mother and foetus. In the case of respiratory-induced heart rate changes, the comparison with maternal surrogates suggests that the evidence for detected synchronization is largely statistical and does not result from physiological interaction. Rather, they simply reflect a stochastic, temporary stability of two independent oscillators with time-variant frequencies. We reanalysed three datasets from that study for a more local consideration. Epochs of assumed synchronization associated with short-term regulation of the foetal heart rate were selected and compared with synchronization resulting from white noise instead of the foetal signal. Using data-driven modelling analysis, it was possible to identify the consistent influence of the heartbeat duration of maternal beats preceding the foetal beats during epochs of synchronization. These maternal beats occurred approximately one maternal respiratory cycle prior to the affected foetal beat. A similar effect could not be found in the epochs without synchronization. Simulations based on the fitted models led to a higher likelihood of synchronization in the data segments with assumed foetal-maternal interaction than in the segment without such assumed interaction. We conclude that the data-driven model-based analysis can be a useful tool for the identification of synchronization. Y1 - 2009 UR - http://rsta.royalsocietypublishing.org/ U6 - https://doi.org/10.1098/rsta.2008.0277 SN - 1364-503X ER - TY - JOUR A1 - Kurths, Jürgen A1 - Schwarz, Udo A1 - Parlitz, Ulrich A1 - Sonett, Charles P. T1 - Testing for nonlinearity in radiocarbon data N2 - The radiocarbon record that has been extended from 7199 BC to 1891 AD is of fundamental importance to understand century-scale variations of solar activity. We have, therefore, studied how to extract information from dynamic reconstructions of this observational record. Using some rather unusual methods of nonlinear dynamics, we have found that the data are significantly different from linear colored noise and that there is some evidence of nonlinear behavior. The method of recurrence plots exhibits that the grand minima of solar activity are quite different in their recurrence. Most remarkably, it suggests that the recent epoch seems to be similar to the Medieval maximum. Y1 - 1994 UR - http://www.agnld.uni-potsdam.de/~shw/Paper/n.ps.gz SN - 1023-5809 ER - TY - JOUR A1 - Allefeld, Carsten A1 - Kurths, Jürgen T1 - Testing for phase synchronization N2 - We present different tests for phase synchronization which improve the procedures currently used in the literature. This is accomplished by using a two-sample test setup and by utilizing insights and methods from directional statistics and bootstrap theory. The tests differ in the generality of the situation in which they can be applied as well as in their complexity, including computational cost. A modification of the resampling technique of the bootstrap is introduced, making it possible to fully utilize data from time series Y1 - 2004 SN - 0218-1274 ER - TY - JOUR A1 - Engbert, Ralf A1 - Hainzl, Sebastian A1 - Zöller, Gert A1 - Kurths, Jürgen T1 - Testing for unstable periodic orbits to characterize spatiotemporal dynamics Y1 - 1998 ER - TY - JOUR A1 - Witt, Annette A1 - Kurths, Jürgen A1 - Pikovskij, Arkadij T1 - Testing stationarity in time series Y1 - 1998 ER - TY - JOUR A1 - Ziehmann, Christine A1 - Smith, L. A1 - Kurths, Jürgen T1 - The bootstrap and lyapunov exponents in deterministic chaos Y1 - 1999 ER - TY - BOOK A1 - Feudel, Ulrike A1 - Kurths, Jürgen A1 - Neiman, Alexander T1 - The cumulant approach for investigating the noise influence on mode-locking bifurcations T3 - Preprint NLD Y1 - 1995 VL - 16 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Florence, Gerson A1 - Dahlem, Markus A. A1 - Almeida, Antônio-Carlos G. A1 - Bassani, José W. M. A1 - Kurths, Jürgen T1 - The role of extracellular potassium dynamics in the different stages of ictal bursting and spreading depression : a computational study N2 - Experimental evidences point Out the participation of nonsynaptic mechanisms (e.g., fluctuations in extracellular tons) in epileptiform bursting and spreading depression (SD). During these abnormal oscillatory patterns, it is observed an increase of extracellular potassium concentration [K+](o) and a decrease of extracellular calcium concentration [Ca2+](o) which raises the neuronal excitability. However, whether the high [K+](o) triggers and propagates these abnormal neuronal activities or plays a secondary role into this process is unclear. To better understand the influence of extracellular potassium dynamics in these oscillatory patterns, the experimental conditions of high [K+](o) and zero [Ca2+](o) were replicated in an extended Golomb model where we added important regulatory mechanisms of ion concentration as Na+-K+ pump, ion diffusion and glial buffering. Within these Conditions, simulations of the cell model exhibit seizure-like discharges (ictal bursting). The SD was elicited by the interruption of the Na+- K+ pump activity, mimicking the effect of cellular hypoxia (an experimental protocol to elicit SD, the hypoxia-induced SD). We used the bifurcation theory and the fast-slow method to analyze the interference of K+ dynamics in the cellular excitability. This analysis indicates that the system loses its stability at a high [K+](o), transiting to an elevated state of neuronal excitability. Effects of high [K+](o), are observed in different stages of ictal bursting and SD. In the initial stage, the increase of [K+](o) creates favorable conditions to trigger both oscillatory patterns. During the neuronal activity, a continuous growth of [K+](o) by outward K+ flow depresses K+ Currents in a positive feedback way. At the last stage, due to the depression of K+ currents, the Na+-K+ pump is the main mechanism in the end of neuronal activity. Thus, this work suggests that [K+](o) dynamics may play a fundamental role in these abnormal oscillatory patterns. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00225193 U6 - https://doi.org/10.1016/j.jtbi.2009.01.032 SN - 0022-5193 ER - TY - JOUR A1 - Traxl, Dominik A1 - Boers, Niklas A1 - Rheinwalt, Aljoscha A1 - Goswami, Bedartha A1 - Kurths, Jürgen T1 - The size distribution of spatiotemporal extreme rainfall clusters around the globe JF - Geophysical research letters N2 - The scaling behavior of rainfall has been extensively studied both in terms of event magnitudes and in terms of spatial extents of the events. Different heavy-tailed distributions have been proposed as candidates for both instances, but statistically rigorous treatments are rare. Here we combine the domains of event magnitudes and event area sizes by a spatiotemporal integration of 3-hourly rain rates corresponding to extreme events derived from the quasi-global high-resolution rainfall product Tropical Rainfall Measuring Mission 3B42. A maximum likelihood evaluation reveals that the distribution of spatiotemporally integrated extreme rainfall cluster sizes over the oceans is best described by a truncated power law, calling into question previous statements about scale-free distributions. The observed subpower law behavior of the distribution's tail is evaluated with a simple generative model, which indicates that the exponential truncation of an otherwise scale-free spatiotemporal cluster size distribution over the oceans could be explained by the existence of land masses on the globe. Y1 - 2016 U6 - https://doi.org/10.1002/2016GL070692 SN - 0094-8276 SN - 1944-8007 VL - 43 SP - 9939 EP - 9947 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Palus, Milan A1 - Kurths, Jürgen A1 - Schwarz, Udo A1 - Seehafer, Norbert A1 - Novotna, Dagmar A1 - Charvatova, Ivanka T1 - The solar activity cycle is weakly synchronized with the solar inertial motion N2 - We study possible interrelations between the 300-year record of the yearly sunspot numbers and the solar inertial motion (SIM) using the recently developed technique of synchronization analysis. Phase synchronization of the sunspot cycle and the SIM is found and statistically confirmed in three epochs (1734-1790, 1855-1875 and 1907-1960) of the whole period 1700-2000. These results give quantitative support to the hypothesis that there is a weak interaction between the solar activity and the SIM. Y1 - 2007 UR - http://www.sciencedirect.com/ science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTHTML&_version=1&_uoikey=B6TVM-4MYVG5S- 1&md5=92d1fc7094be5195504f17e1afb4f0d1 U6 - https://doi.org/10.1016/j.physleta.2007.01.039 ER - TY - JOUR A1 - Boccaletti, Stefano A1 - Kurths, Jürgen A1 - Osipov, Grigory V. T1 - The synchronization of chaotic systems Y1 - 2002 ER - TY - JOUR A1 - Sitz, Andre A1 - Schwarz, Udo A1 - Kurths, Jürgen T1 - The unscented Kalman filter : a powerful tool for data analysis Y1 - 2004 ER - TY - JOUR A1 - Marwan, Norbert A1 - Kurths, Jürgen A1 - Thomsen, Jesper Skovhus A1 - Felsenberg, Dieter A1 - Saparin, Peter T1 - Three-dimensional quantification of structures in trabecular bone using measures of complexity N2 - The study of pathological changes of bone is an important task in diagnostic procedures of patients with metabolic bone diseases such as osteoporosis as well as in monitoring the health state of astronauts during long-term space flights. The recent availability of high-resolution three-dimensional (3D) imaging of bone challenges the development of data analysis techniques able to assess changes of the 3D microarchitecture of trabecular bone. We introduce an approach based on spatial geometrical properties and define structural measures of complexity for 3D image analysis. These measures evaluate different aspects of organization and complexity of 3D structures, such as complexity of its surface or shape variability. We apply these measures to 3D data acquired by high-resolution microcomputed tomography (mu CT) from human proximal tibiae and lumbar vertebrae at different stages of osteoporotic bone loss. The outcome is compared to the results of conventional static histomorphometry and exhibits clear relationships between the analyzed geometrical features of trabecular bone and loss of bone density, but also indicate that the measures reveal additional information about the structural composition of bone, which were not revealed by the static histomorphometry. Finally, we have studied the dependency of the developed measures of complexity on the spatial resolution of the mu CT data sets. Y1 - 2009 UR - http://pre.aps.org/ U6 - https://doi.org/10.1103/Physreve.79.021903 SN - 1539-3755 ER - TY - JOUR A1 - Stolbova, Veronika A1 - Surovyatkina, Elena A1 - Bookhagen, Bodo A1 - Kurths, Jürgen T1 - Tipping elements of the Indian monsoon: Prediction of onset and withdrawal JF - Geophysical research letters N2 - Forecasting the onset and withdrawal of the Indian summer monsoon is crucial for the life and prosperity of more than one billion inhabitants of the Indian subcontinent. However, accurate prediction of monsoon timing remains a challenge, despite numerous efforts. Here we present a method for prediction of monsoon timing based on a critical transition precursor. We identify geographic regions-tipping elements of the monsoon-and use them as observation locations for predicting onset and withdrawal dates. Unlike most predictability methods, our approach does not rely on precipitation analysis but on air temperature and relative humidity, which are well represented both in models and observations. The proposed method allows to predict onset 2 weeks earlier and withdrawal dates 1.5 months earlier than existing methods. In addition, it enables to correctly forecast monsoon duration for some anomalous years, often associated with El Nino-Southern Oscillation. Y1 - 2016 U6 - https://doi.org/10.1002/2016GL068392 SN - 0094-8276 SN - 1944-8007 VL - 43 SP - 3982 EP - 3990 PB - American Geophysical Union CY - Washington ER -