TY  - JOUR
A1  - Induli, Martha
A1  - Cheloti, Michael
A1  - Wasuna, Antonina
A1  - Wekesa, Ingrid
A1  - Wanjohi, John M.
A1  - Byamukama, Robert
A1  - Heydenrich, Matthias
A1  - Makayoto, Moses
A1  - Yenesew, Abiy
T1  - Naphthoquinones from the roots of Aloe secundiflora
JF  - Phytochemistry letters
N2  - Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21-23 mu g/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mu g/mL).
KW  - Aloe secundiflora
KW  - Asphodelaceae
KW  - Roots
KW  - Naphthoquinone
KW  - 5-Hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione 5,8-Dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione
KW  - Anthraquinone
KW  - Aloesaponarin I
KW  - Mycobacterium tuberculosis
Y1  - 2012
U6  - https://doi.org/10.1016/j.phytol.2012.04.014
SN  - 1874-3900
VL  - 5
IS  - 3
SP  - 506
EP  - 509
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abdissa, Negera
A1  - Induli, Martha
A1  - Akala, Hoseah M.
A1  - Heydenreich, Matthias
A1  - Midiwo, Jacob O.
A1  - Ndakala, Albert
A1  - Yenesew, Abiy
T1  - Knipholone cyclooxanthrone and an anthraquinone dimer with antiplasmodial activities from the roots of Kniphofia foliosa
JF  - Phytochemistry letters
N2  - A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively.
KW  - Kniphofia foliosa
KW  - Asphodelaceae
KW  - Roots
KW  - Anthraquinone
KW  - Knipholone cyclooxanthrone
KW  - 10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol
KW  - Dianellin
KW  - Malaria
Y1  - 2013
U6  - https://doi.org/10.1016/j.phytol.2013.02.005
SN  - 1874-3900
VL  - 6
IS  - 2
SP  - 241
EP  - 245
PB  - Elsevier
CY  - Amsterdam
ER  -