TY  - JOUR
A1  - Heringer-Walther, Silvia
A1  - Moreira, Maria da Consolacao V.
A1  - Wessel, Niels
A1  - Wang, Yong
A1  - Ventura, Pago Moreira
A1  - Schultheiss, Heinz-Peter
A1  - Walther, Thomas
T1  - Does the C-type natriuretic peptide have prognostic value in Chagas disease and other dilated cardiomyopathies
JF  - Journal of cardiovascular pharmacology
N2  - Atrial natriuretic peptides (ANP) and brain natriuretic peptides (BNP) are powerful neurohormonal indicators of left-ventricular function and prognosis in heart failure (HF). Chagas disease (CD) caused by the protozoan Trypanosoma cruzi. remains a major cause of HF in Latin America. We assessed whether the plasma concentration of the third natriuretic peptide, C-type natnuretic peptide (CNP), also has diagnostic and prognostic properties in patients with CD or other dilated cardiomyopathies (DCM). Blood samples were obtained from 66 patients with CD, 50 patients with DCM from other causes, and 30 gender- and age-matched healthy subjects. Patients were subdivided according to the New York Heart Association (NYHA) class. The CNP concentration was determined by radioimmunoassay (Immundiagnostik, Bensheim, Germany). The main duration of follow-up was 31.4 months (range 13 to 54 months), 19 patients had died and 11 patients received a heart transplant. CNP concentrations were only significantly altered in patients with DCM or CD of the NYHA classes III and IV (P < 0.05). The Pearson correlation of echocardiographic data with CNP revealed an association only with the left-ventricular end systolic volume (P = 0.03) in patients with DCM. Furthermore, CNP did not predict mortality or the necessity for heart transplant. Our data are the first to demonstrate the raised levels of the third natriuretic peptide CNP in CD and other DCM Whereas ANP and BNP have a high predictive value for mortality in both diseases, CNP is without any predictive potency.
KW  - cardiomyopathy
KW  - heart failure
KW  - natriuretic peptide system
KW  - Trypanosoma cruzi
Y1  - 2006
U6  - https://doi.org/10.1097/01.fjc.0000249892.22635.46
SN  - 0160-2446
VL  - 48
IS  - 6
SP  - 293
EP  - 298
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Delfan, Maryam
A1  - Juybari, Raheleh Amadeh
A1  - Gorgani-Firuzjaee, Sattar
A1  - Nielsen, Jens Høiriis
A1  - Delfan, Neda
A1  - Laher, Ismail
A1  - Saeidi, Ayoub
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats
JF  - Frontiers in Cardiovascular Medicine
N2  - Objective: A role for microRNAs is implicated in several biological and pathological processes. We investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on molecular markers of diabetic cardiomyopathy in rats.

Methods: Eighteen male Wistar rats (260 ± 10 g; aged 8 weeks) with streptozotocin (STZ)-induced type 1 diabetes mellitus (55 mg/kg, IP) were randomly allocated to three groups: control, MICT, and HIIT. The two different training protocols were performed 5 days each week for 5 weeks. Cardiac performance (end-systolic and end-diastolic dimensions, ejection fraction), the expression of miR-206, HSP60, and markers of apoptosis (cleaved PARP and cytochrome C) were determined at the end of the exercise interventions.

Results: Both exercise interventions (HIIT and MICT) decreased blood glucose levels and improved cardiac performance, with greater changes in the HIIT group (p < 0.001, η2: 0.909). While the expressions of miR-206 and apoptotic markers decreased in both training protocols (p < 0.001, η2: 0.967), HIIT caused greater reductions in apoptotic markers and produced a 20% greater reduction in miR-206 compared with the MICT protocol (p < 0.001). Furthermore, both training protocols enhanced the expression of HSP60 (p < 0.001, η2: 0.976), with a nearly 50% greater increase in the HIIT group compared with MICT.

Conclusions: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. It seems however that HIIT is even more effective than MICT to modulate these molecular markers.
KW  - diabetes
KW  - apoptosis
KW  - miRNAs
KW  - exercise
KW  - cardiomyopathy
Y1  - 2022
U6  - https://doi.org/10.3389/fcvm.2022.927956
SN  - 2297-055X
VL  - 9
SP  - 1
EP  - 11
PB  - Frontiers
CY  - Lausanne, Schweiz
ER  -