TY  - JOUR
A1  - Tschorn, Mira
A1  - Rieckmann, Nina
A1  - Arolt, Volker
A1  - Beer, Katja
A1  - Haverkamp, Wilhelm
A1  - Martus, Peter
A1  - Waltenberger, Johannes
A1  - Müller-Nordhorn, Jacqueline
A1  - Ströhle, Andreas
T1  - Erkennungsgüte dreier deutschsprachiger Screeninginstrumente für Depression bei hospitalisierten Patienten mit koronarer Herzerkrankung
T1  - Diagnostic Accuracy of German Depression Screenings in Patients with Coronary Heart Disease
JF  - Psychiatrische Praxis
N2  - Ziel Vergleich der Erkennungsgüte von drei Depressions-Screeninginstrumenten bei Patienten mit koronarer Herzerkrankung (KHK).
Methodik 1019 KHK-Patienten erhielten den Patient Health Questionnaire (PHQ-9 und PHQ-2) und die Hospital Anxiety and Depression Scale (HADS-D) sowie ein klinisches Interview (Composite International Diagnostic Interview) als Referenzstandard.
Ergebnisse Bezüglich der Erkennungsgüte waren PHQ-9 und HADS-D dem PHQ-2 überlegen. Optimale Cut-off-Werte waren 7 (PHQ-9 und HADS-D) und 2 (PHQ-2).
Schlussfolgerung PHQ-9 und HADS-D haben eine vergleichbare Diskriminationsfähigkeit für depressive Störungen bei KHK-Patienten.
N2  - Objective To compare the diagnostic accuracy of German depression screening instruments in patients with coronary heart disease (CHD). Methods 1019 CHD patients completed the Patient Health Questionnaire (PHQ-9 and PHQ-2) and the Hospital Anxiety and Depression Scale (HADS-D). The Composite International Diagnostic Interview served as reference standard for "any depressive disorder" and "major depression". Results The accuracy of the PHQ-9 and the HADS-D was comparable according to the area under the curve, and both were superior to the PHQ-2. The optimal cut-off according to the Youden index (maximum sum of sensitivity and specificity) was 7 for both instruments. At this optimal cut-off, the PHQ-9 had a higher sensitivity compared to the HADS-D, but a lower specificity (below 68). Results remained similar when patients who reported that they currently underwent treatment for depression were excluded. Conclusion The PHQ-9 and the HADS-D have comparable overall diagnostic accuracy in CHD patients. In line with previous screening studies with CHD patients, the optimal cut-offs were below the cut-offs that are recommended in the literature.
KW  - coronary artery disease
KW  - depression
KW  - diagnosis
KW  - screening
KW  - validity
Y1  - 2019
U6  - https://doi.org/10.1055/s-0042-123434
SN  - 0303-4259
SN  - 1439-0876
VL  - 46
IS  - 1
SP  - 41
EP  - 48
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Gebser, Martin
A1  - Schaub, Torsten H.
A1  - Thiele, Sven
A1  - Veber, Philippe
T1  - Detecting inconsistencies in large biological networks with answer set programming
JF  - Theory and practice of logic programming
N2  - We introduce an approach to detecting inconsistencies in large biological networks by using answer set programming. To this end, we build upon a recently proposed notion of consistency between biochemical/genetic reactions and high-throughput profiles of cell activity. We then present an approach based on answer set programming to check the consistency of large-scale data sets. Moreover, we extend this methodology to provide explanations for inconsistencies by determining minimal representations of conflicts. In practice, this can be used to identify unreliable data or to indicate missing reactions.
KW  - answer set programming
KW  - bioinformatics
KW  - consistency
KW  - diagnosis
Y1  - 2011
U6  - https://doi.org/10.1017/S1471068410000554
SN  - 1471-0684
VL  - 11
IS  - 5-6
SP  - 323
EP  - 360
PB  - Cambridge Univ. Press
CY  - New York
ER  -