TY - JOUR A1 - Kruckenberg, Helmut A1 - Müller, Thomas A1 - Freuling, Conrad A1 - Mühle, Ralf-Udo A1 - Globig, Anja A1 - Schirrmeier, Horst A1 - Buss, Melanie A1 - Harder, Timm A1 - Kramer, Matthias A1 - Teske, Kathrin A1 - Polderdijk, Kees A1 - Wallschläger, Hans-Dieter A1 - Hlinak, Andreas T1 - Serological and virological survey and resighting of marked wild geese in Germany JF - European journal of wildlife research N2 - In order to investigate the potential role of arctic geese in the epidemiology, the spatial and temporal spread of selected avian diseases, in autumn 2002, a virological and serological survey designed as capture-mark-resighting study was conducted in one of the most important coastal resting sites for migratory waterfowl in Germany. Orophatyngeal, cloacal swabs and blood samples were collected from a total of 147 birds comprising of three different arctic geese species including White-fronted Goose (Anser albifrons), Tundra Bean Goose (Anser fabalis rossicus), Pink-footed Goose (Anser brachyrhynchus) as well as from 29 non-migratory Canada Geese (Branta canadensis). Altogether, six adeno-like viruses (ALV; 95% CI, 1.74-9.92%) and two avian paramyxoviruses (APMV-4; 95% Cl, 0.19-5.53%) were isolated mainly from juvenile White-fronted Geese. In addition, four Canada Geese were infected with lentogenic APMV-1 (95% CI, 3.89-31.66%) at the date of sampling. No avian influenza viruses, reo-like viruses could be isolated despite serological evidence. Likewise, no evidence of current or previous infection by West Nile virus was found. Of the 147 birds tagged in the following years, 137 birds were resighted between 2002 and 2008 accumulating to 1925 sightings. About 90% of all sightings were reported from the main wintering and resting sites in Germany and The Netherlands. Eight of the resighted geese were virus positive (ALV and APMV-4) at the time point of sampling in 2002. KW - Wild geese KW - Anser albifrons KW - White-fronted goose KW - Disease KW - Spatial distribution KW - Winter KW - Distribution KW - Branta canadensis KW - Canada goose KW - Virus KW - Infection KW - Neckbanding Y1 - 2011 U6 - https://doi.org/10.1007/s10344-011-0514-1 SN - 1612-4642 VL - 57 IS - 5 SP - 1025 EP - 1032 PB - Springer CY - New York ER - TY - JOUR A1 - Reichel, Martin A1 - Hoenig, Stefanie A1 - Liebisch, Gerhard A1 - Lüth, Anja A1 - Kleuser, Burkhard A1 - Gulbins, Erich A1 - Schmitz, Gerd A1 - Kornhuber, Johannes T1 - Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients JF - Biochimica et biophysica acta : Molecular and cell biology of lipids N2 - Background: Alcohol abuse is a major risk factor for somatic and neuropsychiatric diseases. Despite their potential clinical importance, little is known about the alterations of plasma glycerophospholipid (GPL) and sphingolipid (SPL) species associated with alcohol abuse. Methods: Plasma GPL and SPL species were quantified using electrospray ionization tandem mass spectrometry in samples from 23 male alcohol-dependent patients before and after detoxification, as well as from 20 healthy male controls. Results: A comparison of alcohol-dependent patients with controls revealed higher phosphatidylcholine (PC; P-value = 0.008) and phosphatidylinositol (PI; P-value = 0.001) concentrations in patients before detoxification, and higher PI (P-value = 0.001) and phosphatidylethanolamine (PE)-based plasmalogen (PEP; P-value = 0.003) concentrations after detoxification. Lysophosphatidylcholines (LPC) were increased by acute intoxication (P-value = 0.002). Sphingomyelin (SM) concentration increased during detoxification (P-value = 0.011). The concentration of SM 23:0 was lower in patients (P-value = 2.79 x 10(-5)), and the concentrations of ceramide Cer d18:1/16:0 and Cer d18:1/18:0 were higher in patients (P-value = 2.45 x 10(-5) and 3.73 x 10(-5)). Activity of lysosomal acid sphingomyelinase (ASM) in patients correlated positively with the concentrations of eight LPC species, while activity of secreted ASM was inversely correlated with several PE, PI and PC species, and positively correlated with the molar ratio of PC to SM (Pearson's r = 0.432; P-value = 0.039). Conclusion: Plasma concentrations of numerous GPL and SPL species were altered in alcohol-dependent patients. These molecules might serve as potential biomarkers to improve the diagnosis of patients and to indicate health risks associated with alcohol abuse. Our study further indicates that there are strong interactions between plasma GPL concentrations and SPL metabolism. (C) 2015 Elsevier B.V. All rights reserved. KW - Acid sphingomyelinase KW - Alcohol dependence KW - Anxiety KW - Cardiovascular KW - Case-control study KW - Ceramide KW - Clinical KW - Depression KW - Diagnostic KW - Disease KW - Glycerophospholipids KW - Lysophosphatidylcholines KW - Mass spectrometry KW - Phosphatidylcholines KW - Phosphatidylinositols KW - Plasma KW - Plasmalogens KW - Sphingolipids KW - Sphingomyelin KW - Tandem mass spectrometry Y1 - 2015 U6 - https://doi.org/10.1016/j.bbalip.2015.08.005 SN - 1388-1981 SN - 0006-3002 VL - 1851 IS - 11 SP - 1501 EP - 1510 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - de Vinuesa, Amaya Garcia A1 - Abdelilah-Seyfried, Salim A1 - Knaus, Petra A1 - Zwijsen, An A1 - Bailly, Sabine T1 - BMP signaling in vascular biology and dysfunction JF - New journal of physics : the open-access journal for physics N2 - The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved. KW - Bone morphogenetic proteins (BMP) KW - Signaling KW - Vasculature KW - Development KW - Disease Y1 - 2016 U6 - https://doi.org/10.1016/j.cytogfr.2015.12.005 SN - 1359-6101 SN - 1879-0305 VL - 27 SP - 65 EP - 79 PB - Elsevier CY - Oxford ER -