TY  - JOUR
A1  - Karuwanarint, Piyaporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Suriyaprom, Kanjana
A1  - Chuengsamarn, Somlak
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
T1  - Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
JF  - Biomarkers in medicine
N2  - Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GCglobulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
KW  - GC gene
KW  - GC-globulin
KW  - metabolic syndrome
KW  - polymorphism
KW  - Thai population
KW  - vitamin D-binding protein
Y1  - 2018
U6  - https://doi.org/10.2217/bmm-2018-0029
SN  - 1752-0363
SN  - 1752-0371
VL  - 12
IS  - 5
SP  - 465
EP  - 473
PB  - Future Medicine
CY  - London
ER  -