TY  - GEN
A1  - Tschorn, Mira
A1  - Kuhlmann, Stella Linnea
A1  - Rieckmann, Nina
A1  - Beer, Katja
A1  - Grosse, Laura
A1  - Arolt, Volker
A1  - Waltenberger, Johannes
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Objective:
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). 

Methods: 
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. 

Results: 
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. 

Conclusion: 
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 850 
KW  - depression
KW  - BDNF
KW  - coronary heart disease
KW  - heart failure
KW  - somatic comorbidity
KW  - acute coronary syndrome
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557315
SN  - 1866-8364
IS  - 1
ER  - 
TY  - JOUR
A1  - Tschorn, Mira
A1  - Kuhlmann, Stella Linnea
A1  - Rieckmann, Nina
A1  - Beer, Katja
A1  - Grosse, Laura
A1  - Arolt, Volker
A1  - Waltenberger, Johannes
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease
JF  - Acta Neuropsychiatrica
N2  - Objective: 
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). 

Methods: 
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. 

Results: 
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. 

Conclusion: 
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
KW  - depression
KW  - BDNF
KW  - coronary heart disease
KW  - heart failure
KW  - somatic comorbidity
KW  - acute coronary syndrome
Y1  - 2020
U6  - https://doi.org/10.1017/neu.2020.31
SN  - 1601-5215
SN  - 0924-2708
VL  - 33
IS  - 1
SP  - 22
EP  - 30
PB  - Cambridge Univ. Press
CY  - Cambridge
ER  -