TY  - JOUR
A1  - Bornhorst, Dorothee
A1  - Abdelilah-Seyfried, Salim
T1  - Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development
JF  - Frontiers in Cell and Developmental Biology
N2  - The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated. Here, we discuss the roles of mechanosensitive Hippo signaling in growth and morphogenesis of the zebrafish heart. Hippo signaling is involved in defining numbers of cardiac progenitor cells derived from the secondary heart field, in restricting the growth of the epicardium, and in guiding trabeculation and outflow tract formation. Recent work also shows that myocardial chamber dimensions serve as a blueprint for Hippo signaling-dependent growth of the endocardium. Evidently, Hippo pathway components act at the crossroads of various signaling pathways involved in embryonic zebrafish heart development. Elucidating how biomechanical Hippo signaling guides heart morphogenesis has direct implications for our understanding of cardiac physiology and pathophysiology.
KW  - Hippo signaling
KW  - Yap1/Wwtr1 (Taz)
KW  - cardiac development
KW  - mechanobiology
KW  - endocardium
KW  - myocardium
KW  - zebrafish
KW  - intra-organ-communication
Y1  - 2021
U6  - https://doi.org/10.3389/fcell.2021.731101
SN  - 2296-634X
VL  - 9
SP  - 1
EP  - 10
PB  - Frontiers Media
CY  - Lausanne, Schweiz
ER  -