TY  - JOUR
A1  - Kuroki, Agnes
A1  - Tchoupa, Arnaud Kengmo
A1  - Hartlieb, Matthias
A1  - Peltier, Raoul
A1  - Locock, Katherine E. S.
A1  - Unnikrishnan, Meera
A1  - Perrier, Sebastien
T1  - Targeting intracellular, multi-drug resistant Staphylococcus aureus with guanidinium polymers by elucidating the structure-activity relationship
JF  - Biomaterials : biomaterials reviews online
N2  - Intracellular persistence of bacteria represents a clinical challenge as bacteria can thrive in an environment protected from antibiotics and immune responses. Novel targeting strategies are critical in tackling antibiotic resistant infections. Synthetic antimicrobial peptides (SAMPs) are interesting candidates as they exhibit a very high antimicrobial activity. We first compared the activity of a library of ammonium and guanidinium polymers with different sequences (statistical, tetrablock and diblock) synthesized by RAFT polymerization against methicillin-resistant S. aureus (MRSA) and methicillin-sensitive strains (MSSA). As the guanidinium SAMPs were the most potent, they were used to treat intracellular S. aureus in keratinocytes. The diblock structure was the most active, reducing the amount of intracellular MSSA and MRSA by two-fold. We present here a potential treatment for intracellular, multi-drug resistant bacteria, using a simple and scalable strategy.
KW  - Antimicrobial
KW  - Intracellular bacteria
KW  - Block copolymers
KW  - RAFT polymerization
Y1  - 2019
U6  - https://doi.org/10.1016/j.biomaterials.2019.119249
SN  - 0142-9612
SN  - 1878-5905
VL  - 217
PB  - Elsevier
CY  - Oxford
ER  -