TY  - JOUR
A1  - Libuda, Lars
A1  - Mesch, Christina M.
A1  - Stimming, Madlen
A1  - Demmelmair, Hans
A1  - Koletzko, Berthold
A1  - Warschburger, Petra
A1  - Blanke, Katharina
A1  - Reischl, Eva
A1  - Kalhoff, Hermann
A1  - Kersting, Mathilde
T1  - Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial
JF  - European journal of nutrition
N2  - Purpose Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breast-feeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status. Methods Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids. Results Complete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p < 0.001). In IG-R, levels of ALA and the ratio of ALA to LA in plasma and RBC (all p < 0.0001) as well as RBC-EPA (p < 0.0001) were higher than in CG, while DHA levels did not differ between IG-R and CG. Conclusions Regular fish consumption during complementary feeding enhances infant EPA and DHA status. The usage of rapeseed oil in small amounts concordant with EU-law for commercial meals enhances endogenic EPA-synthesis, but does not affect DHA status. Provision of oily fish with complementary feeds is advisable to prevent a decline of DHA status. Clinical Trial Registration www.clinicaltrials.gov, identifier: NCT01487889, title: Polyunsaturated fatty acids in child nutrition-a German multimodal optimisation study (PINGU).
KW  - DHA
KW  - Fish
KW  - Rapeseed oil
KW  - Complementary food
KW  - Complementary feeding
KW  - Alpha-linolenic acid
KW  - DHA status
Y1  - 2016
U6  - https://doi.org/10.1007/s00394-015-0982-2
SN  - 1436-6207
SN  - 1436-6215
VL  - 55
SP  - 1633
EP  - 1644
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Hartwich, Melanie
A1  - Martin-Creuzburg, Dominik
A1  - Wacker, Alexander
T1  - Seasonal changes in the accumulation of polyunsaturated fatty acids in zooplankton
JF  - Journal of plankton research
N2  - In aquatic food webs, consumers, such as daphnids and copepods, differ regarding their accumulation of polyunsaturated fatty acids (PUFAs). We tested if the accumulation of PUFAs in a seston size fraction containing different consumers and in Daphnia as a separate consumer is subject to seasonal changes in a large deep lake due to changes in the dietary PUFA supply and specific demands of different consumers. We found that the accumulation of arachidonic acid (ARA) in Daphnia increased from early summer to late summer and autumn. However, ARA requirements of Daphnia appeared to be constant throughout the year, because the accumulation of ARA increased when the dietary ARA supply decreased. In the size fraction 140 m, we found an increased accumulation of docosahexaenoic acid (DHA) during late summer and autumn. These seasonal changes in DHA accumulation were linked to changes in the proportion of copepods in this size fraction, which may have increasingly accumulated DHA for active overwintering. We show that consumer-specific PUFA demands can result in seasonal changes in PUFA accumulation, which may influence the trophic transfer of PUFAs within the food web.
KW  - accumulation
KW  - Daphnia
KW  - copepods
KW  - ARA
KW  - DHA
Y1  - 2013
U6  - https://doi.org/10.1093/plankt/fbs078
SN  - 0142-7873
VL  - 35
IS  - 1
SP  - 121
EP  - 134
PB  - Oxford Univ. Press
CY  - Oxford
ER  -