TY  - JOUR
A1  - Holz, Nathalie E.
A1  - Boecker-Schlier, Regina
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Baumeister, Sarah
A1  - Plichta, Michael M.
A1  - Cattrell, Anna
A1  - Schumann, Gunter
A1  - Esser, Günter
A1  - Schmidt, Martin
A1  - Buitelaar, Jan
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
JF  - Frontiers in human neuroscience
N2  - Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years).

CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.
KW  - childhood adversity
KW  - conduct disorder
KW  - amygdala
KW  - ventral striatum
KW  - fMRI
Y1  - 2016
U6  - https://doi.org/10.1093/scan/nsw120
SN  - 1749-5016
SN  - 1749-5024
VL  - 12
IS  - 2
SP  - 261
EP  - 272
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Zohsel, Katrin
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Hohm, Erika
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Brandeis, Daniel
A1  - Banaschewski, Tobias
A1  - Laucht, Manfred
T1  - Mothers' prenatal stress and their children's antisocial outcomes - a  moderating role for the dopamine receptor D4 (DRD4) gene
JF  - The journal of child psychology and psychiatry
N2  - ResultsUnder conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress.
 ConclusionsThis study is the first to report a gene-environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior.
KW  - Prenatal stress
KW  - antisocial
KW  - conduct disorder
KW  - DRD4
KW  - gene-environment interaction
Y1  - 2014
U6  - https://doi.org/10.1111/jcpp.12138
SN  - 0021-9630
SN  - 1469-7610
VL  - 55
IS  - 1
SP  - 69
EP  - 76
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -