TY  - JOUR
A1  - Chea, Sany
A1  - Nguyen, Khac Toan
A1  - Rosencrantz, Ruben R.
T1  - Microwave-Assisted Synthesis of 5 '-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435
JF  - Molecules
N2  - Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5 ' position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5 '-O-methacryloylcytidine with the assistance of microwave irradiation. Variable reaction parameters, such as enzyme concentration, molar ratio of the substrate, reaction temperature and reaction time, were investigated to find the optimum reaction condition in terms of obtaining the highest yield.
KW  - microwave irradiation
KW  - Novozym 435
KW  - cytidine
KW  - monomer
KW  - smart materials
Y1  - 2022
U6  - https://doi.org/10.3390/molecules27134112
SN  - 1420-3049
VL  - 27
IS  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schmidt, Bernd
A1  - Riemer, Martin
T1  - Synthesis of Allyl- and Prenylcoumarins via Microwave-Promoted Tandem Claisen Rearrangement/Wittig Olefination
JF  - Synthesis
N2  - Allyl, dimethylallyl, crotyl, and prenyl ethers of various aromatic ortho-hydroxy carbonyl compounds undergo a tandem sequence of Claisen rearrangement, carbonyl olefination, and cyclization upon microwave irradiation in the presence of a stabilized ylide. The products are multiply substituted 6- or 8-allylated or prenylated coumarins (2H-chromen-2-ones).
KW  - aldehydes
KW  - coumarins
KW  - ketones
KW  - microwave irradiation
KW  - olefination
KW  - tandem reaction
KW  - ylides
Y1  - 2016
U6  - https://doi.org/10.1055/s-0035-1560501
SN  - 0039-7881
SN  - 1437-210X
VL  - 48
SP  - 141
EP  - 149
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Schmidt, Bernd
A1  - Riemer, Martin
T1  - Microwave-Promoted Deprenylation: Prenyl Ether as a Thermolabile Phenol Protecting Group
JF  - Synthesis
N2  - para-Substituted aryl prenyl ethers undergo a deprenylation reaction upon microwave irradiation. This offers the opportunity to use a prenyl ether as a thermolabile protecting group in the synthesis of natural products with a chromone structure, which proceeds via a tandem deprenylation/6-endo-cyclization sequence.
KW  - microwave irradiation
KW  - phenols
KW  - chromenes
KW  - protecting groups
KW  - Claisen rearrangement
Y1  - 2016
U6  - https://doi.org/10.1055/s-0035-1561366
SN  - 0039-7881
SN  - 1437-210X
VL  - 48
SP  - 1399
EP  - 1406
PB  - Thieme
CY  - Stuttgart
ER  -