TY - JOUR A1 - Schomöller, Anne A1 - Schugardt, Monique A1 - Kotsch, Peggy A1 - Mayer, Frank T1 - The effect of body composition on cycling power during an incremental test in young athletes JF - Journal of strength and conditioning research : the research journal of the NSCA / National Strength & Conditioning Association N2 - Schomoller, A, Schugardt, M, Kotsch, P, and Mayer, F. The effect of body composition on cycling power during an incremental test in young athletes. J Strength Cond Res 35(11): 3225-3231, 2021-As body composition (BC) is a modifiable factor influencing sports performance, it is of interest for athletes and coaches to optimize BC to fulfill the specific physical demands of one sport discipline. The purpose of this study is to test the impact of body fat (BF) and fat-free mass (FFM) on aerobic performance in young athletes. Body composition parameters were evaluated among gender and age groups of young athletes undergoing their mandatory health examination. The maximal power (in Watts per kilogram body mass) of a stepwise incremental ergometer test was compared between 6 BC types: high BF, high FFM, high BF and high FFM, normal BC values, low BF, and low FFM. With increasing age (11-13 vs. 14-16 years) BF decreased and FFM increased in both genders. Both BC parameters, as well as body mass, correlated moderately with performance output (r = 0.36-0.6). Subjects with high BF or high FFM or both had significantly lower ergometer test results compared with those with low BF and FFM in all age and gender groups (p < 0.05). The finding that high levels of BF and FFM are detrimental for cycle power output is important to consider in disciplines that demand high levels of aerobic and anaerobic performance. KW - youth competitive sport KW - body fat KW - fat-free mass KW - cycling performance Y1 - 2020 U6 - https://doi.org/10.1519/JSC.0000000000003271 SN - 1064-8011 SN - 1533-4287 VL - 35 IS - 11 SP - 3225 EP - 3231 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Schomöller, Anne A1 - Weis, Katharina A1 - von Barby, Reena A1 - Hübler, Axel A1 - Mayer, Frank A1 - Erler, Thomas T1 - Restless legs syndrome in childhood and adolescence BT - Applicability of aquestionnaire designed to assess disease-related symptoms JF - Somnologie : Schlafforschung und Schlafmedizin ; Organ der Deutschen Gesellschaft für Schlafforschung und Schlafmedizin (DGSM) KW - Sleep KW - Child KW - Adolescent KW - Questionnaires KW - Diagnostic techniques and procedures KW - RLS Y1 - 2019 U6 - https://doi.org/10.1007/s11818-018-0188-y SN - 1432-9123 SN - 1439-054X VL - 23 IS - 2 SP - 104 EP - 108 PB - Springer CY - Cham ER - TY - JOUR A1 - Risch, Lucie A1 - Stoll, Josefine A1 - Schomöller, Anne A1 - Engel, Tilman A1 - Mayer, Frank A1 - Cassel, Michael T1 - Intraindividual Doppler Flow Response to Exercise Differs Between Symptomatic and Asymptomatic Achilles Tendons JF - Frontiers in physiology N2 - Objective: This study investigated intraindividual differences of intratendinous blood flow (IBF) in response to running exercise in participants with Achilles tendinopathy. Design: This is a cross-sectional study. Setting: The study was conducted at the University Outpatient Clinic. Participants: Sonographic detectable intratendinous blood flow was examined in symptomatic and contralateral asymptomatic Achilles tendons of 19 participants (42 ± 13 years, 178 ± 10 cm, 76 ± 12 kg, VISA-A 75 ± 16) with clinically diagnosed unilateral Achilles tendinopathy and sonographic evident tendinosis. Intervention: IBF was assessed using Doppler ultrasound “Advanced Dynamic Flow” before (Upre) and 5, 30, 60, and 120 min (U5–U120) after a standardized submaximal constant load run. Main Outcome Measure: IBF was quantified by counting the number (n) of vessels in each tendon. Results: At Upre, IBF was higher in symptomatic compared with asymptomatic tendons [mean 6.3 (95% CI: 2.8–9.9) and 1.7 (0.4–2.9), p < 0.01]. Overall, 63% of symptomatic and 47% of asymptomatic Achilles tendons responded to exercise, whereas 16 and 11% showed persisting IBF and 21 and 42% remained avascular throughout the investigation. At U5, IBF increased in both symptomatic and asymptomatic tendons [difference to baseline: 2.4 (0.3–4.5) and 0.9 (0.5–1.4), p = 0.05]. At U30 to U120, IBF was still increased in symptomatic but not in asymptomatic tendons [mean difference to baseline: 1.9 (0.8–2.9) and 0.1 (-0.9 to 1.2), p < 0.01]. Conclusion: Irrespective of pathology, 47–63% of Achilles tendons responded to exercise with an immediate acute physiological IBF increase by an average of one to two vessels (“responders”). A higher amount of baseline IBF (approximately five vessels) and a prolonged exercise-induced IBF response found in symptomatic ATs indicate a pain-associated altered intratendinous “neovascularization.” KW - achilles tendinopathy KW - tendinosis KW - neovascularization KW - ultrasound KW - advanced dynamic flow KW - sonography Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.617497 SN - 1664-042X VL - 12 SP - 1 EP - 8 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - GEN A1 - Risch, Lucie A1 - Stoll, Josefine A1 - Schomöller, Anne A1 - Engel, Tilman A1 - Mayer, Frank A1 - Cassel, Michael T1 - Intraindividual Doppler Flow Response to Exercise Differs Between Symptomatic and Asymptomatic Achilles Tendons T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Objective: This study investigated intraindividual differences of intratendinous blood flow (IBF) in response to running exercise in participants with Achilles tendinopathy. Design: This is a cross-sectional study. Setting: The study was conducted at the University Outpatient Clinic. Participants: Sonographic detectable intratendinous blood flow was examined in symptomatic and contralateral asymptomatic Achilles tendons of 19 participants (42 ± 13 years, 178 ± 10 cm, 76 ± 12 kg, VISA-A 75 ± 16) with clinically diagnosed unilateral Achilles tendinopathy and sonographic evident tendinosis. Intervention: IBF was assessed using Doppler ultrasound “Advanced Dynamic Flow” before (Upre) and 5, 30, 60, and 120 min (U5–U120) after a standardized submaximal constant load run. Main Outcome Measure: IBF was quantified by counting the number (n) of vessels in each tendon. Results: At Upre, IBF was higher in symptomatic compared with asymptomatic tendons [mean 6.3 (95% CI: 2.8–9.9) and 1.7 (0.4–2.9), p < 0.01]. Overall, 63% of symptomatic and 47% of asymptomatic Achilles tendons responded to exercise, whereas 16 and 11% showed persisting IBF and 21 and 42% remained avascular throughout the investigation. At U5, IBF increased in both symptomatic and asymptomatic tendons [difference to baseline: 2.4 (0.3–4.5) and 0.9 (0.5–1.4), p = 0.05]. At U30 to U120, IBF was still increased in symptomatic but not in asymptomatic tendons [mean difference to baseline: 1.9 (0.8–2.9) and 0.1 (-0.9 to 1.2), p < 0.01]. Conclusion: Irrespective of pathology, 47–63% of Achilles tendons responded to exercise with an immediate acute physiological IBF increase by an average of one to two vessels (“responders”). A higher amount of baseline IBF (approximately five vessels) and a prolonged exercise-induced IBF response found in symptomatic ATs indicate a pain-associated altered intratendinous “neovascularization.” T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 746 KW - achilles tendinopathy KW - tendinosis KW - neovascularization KW - ultrasound KW - advanced dynamic flow KW - sonography Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-542865 SN - 1866-8364 SP - 1 EP - 8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schomöller, Anne A1 - Risch, Lucie A1 - Kaplick, Hannes A1 - Wochatz, Monique A1 - Engel, Tilman A1 - Schraplau, Anne A1 - Sonnenburg, Dominik A1 - Huppertz, Alexander A1 - Mayer, Frank T1 - Inter-rater and inter-session reliability of lumbar paraspinal muscle composition in a mobile MRI device JF - BJR : an international journal of radiology, radiation oncology and all related sciences / British Institute of Radiology N2 - Objective: To assess the reliability of measurements of paraspinal muscle transverse relaxation times (T2 times) between two observers and within one observer on different time points.
Methods: 14 participants (9f/5m, 33 +/- 5 years, 176 +/- 10 cm, 73 +/- 12 kg) underwent 2 consecutive MRI scans (M1,M2) on the same day, followed by 1 MRI scan 13-14 days later (M3) in a mobile 1.5 Tesla MRI. T2 times were calculated in T-2 weighted turbo spin- echo-sequences at the spinal level of the third lumbar vertebrae (11 slices, 2 mm slice thickness, 1 mm interslice gap, echo times: 20, 40, 60, 80, 100 ms) for M. erector spinae (ES) and M. multifidius (MF). The following reliability parameter were calculated for the agreement of T2 times between two different investigators (OBS1 & OBS2) on the same MRI (inter rater reliability, IR) and by one investigator between different MRI of the same participant (intersession variability, IS): Test-Retest Variability (TRV, Differences/Mean*100); Coefficient of Variation (CV, Standard deviation/Mean*100); Bland-Altman Analysis (systematic bias = Mean of the Differences; Upper/Lower Limits of Agreement = Bias+/-1.96*SD); Intraclass Correlation Coefficient 3.1 (ICC) with absolute agreement, as well as its 95% confidence interval.
Results: Mean TRV for IR was 2.6% for ES and 4.2% for MF. Mean TRV for IS was 3.5% (ES) and 5.1% (MF). Mean CV for IR was 1.9 (ES) and 3.0 (MF). Mean CV for IS was 2.5% (ES) and 3.6% (MF). A systematic bias of 1.3 ms (ES) and 2.1 ms (MF) were detected for IR and a systematic bias of 0.4 ms (ES) and 0.07 ms (MF) for IS. ICC for IR was 0.94 (ES) and 0.87 (MF). ICC for IS was 0.88 (ES) and 0.82 (MF).
Conclusion: Reliable assessment of paraspinal muscle T2 time justifies its use for scientific purposes. The applied technique could be recommended to use for future studies that aim to assess changes of T2 times, e.g. after an intense bout of eccentric exercises. Y1 - 2021 U6 - https://doi.org/10.1259/bjr.20210141 SN - 0007-1285 SN - 1748-880X VL - 94 IS - 1127 PB - Wiley CY - Bognor Regis ER - TY - JOUR A1 - Engel, Tilman A1 - Schraplau, Anne A1 - Wochatz, Monique A1 - Kopinski, Stephan A1 - Sonnenburg, Dominik A1 - Schomöller, Anne A1 - Risch, Lucie A1 - Kaplick, Hannes A1 - Mayer, Frank T1 - Feasability of An Eccentric Isokinetic Protocol to Induce Trunk Muscle Damage: A Pilot Study JF - Sports Medicine International Open N2 - Eccentric exercise is discussed as a treatment option for clinical populations, but specific responses in terms of muscle damage and systemic inflammation after repeated loading of large muscle groups have not been conclusively characterized. Therefore, this study tested the feasibility of an isokinetic protocol for repeated maximum eccentric loading of the trunk muscles. Nine asymptomatic participants (5 f/4 m; 34±6 yrs; 175±13 cm; 76±17 kg) performed three isokinetic 2-minute all-out trunk strength tests (1x concentric (CON), 2x eccentric (ECC1, ECC2), 2 weeks apart; flexion/extension, 60°/s, ROM 55°). Outcomes were peak torque, torque decline, total work, and indicators of muscle damage and inflammation (over 168 h). Statistics were done using the Friedman test (Dunn’s post-test). For ECC1 and ECC2, peak torque and total work were increased and torque decline reduced compared to CON. Repeated ECC bouts yielded unaltered torque and work outcomes. Muscle damage markers were highest after ECC1 (soreness 48 h, creatine kinase 72 h; p<0.05). Their overall responses (area under the curve) were abolished post-ECC2 compared to post-ECC1 (p<0.05). Interleukin-6 was higher post-ECC1 than CON, and attenuated post-ECC2 (p>0.05). Interleukin-10 and tumor necrosis factor-α were not detectable. All markers showed high inter-individual variability. The protocol was feasible to induce muscle damage indicators after exercising a large muscle group, but the pilot results indicated only weak systemic inflammatory responses in asymptomatic adults. KW - exercise KW - eccentric KW - muscle fatigue KW - trunk muscles KW - isokinetics KW - repeated bout effect KW - inflammation KW - exercise induced muscle damage KW - interleukin-6 KW - internleukin-10 KW - tumor necrosis factor-α Y1 - 2021 U6 - https://doi.org/10.1055/a-1757-6724 SN - 2367-1890 VL - 6 SP - E9 EP - E17 PB - Thieme CY - Stuttgart ET - 1 ER - TY - GEN A1 - Engel, Tilman A1 - Schraplau, Anne A1 - Wochatz, Monique A1 - Kopinski, Stephan A1 - Sonnenburg, Dominik A1 - Schomöller, Anne A1 - Risch, Lucie A1 - Kaplick, Hannes A1 - Mayer, Frank T1 - Feasability of An Eccentric Isokinetic Protocol to Induce Trunk Muscle Damage: A Pilot Study T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Eccentric exercise is discussed as a treatment option for clinical populations, but specific responses in terms of muscle damage and systemic inflammation after repeated loading of large muscle groups have not been conclusively characterized. Therefore, this study tested the feasibility of an isokinetic protocol for repeated maximum eccentric loading of the trunk muscles. Nine asymptomatic participants (5 f/4 m; 34±6 yrs; 175±13 cm; 76±17 kg) performed three isokinetic 2-minute all-out trunk strength tests (1x concentric (CON), 2x eccentric (ECC1, ECC2), 2 weeks apart; flexion/extension, 60°/s, ROM 55°). Outcomes were peak torque, torque decline, total work, and indicators of muscle damage and inflammation (over 168 h). Statistics were done using the Friedman test (Dunn’s post-test). For ECC1 and ECC2, peak torque and total work were increased and torque decline reduced compared to CON. Repeated ECC bouts yielded unaltered torque and work outcomes. Muscle damage markers were highest after ECC1 (soreness 48 h, creatine kinase 72 h; p<0.05). Their overall responses (area under the curve) were abolished post-ECC2 compared to post-ECC1 (p<0.05). Interleukin-6 was higher post-ECC1 than CON, and attenuated post-ECC2 (p>0.05). Interleukin-10 and tumor necrosis factor-α were not detectable. All markers showed high inter-individual variability. The protocol was feasible to induce muscle damage indicators after exercising a large muscle group, but the pilot results indicated only weak systemic inflammatory responses in asymptomatic adults. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 773 KW - exercise KW - eccentric KW - muscle fatigue KW - trunk muscles KW - isokinetics KW - repeated bout effect KW - inflammation KW - exercise induced muscle damage KW - interleukin-6 KW - internleukin-10 KW - tumor necrosis factor-α Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557409 SN - 1866-8364 SP - E9 EP - E17 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Schraplau, Anne A1 - Sonnenburg, Dominik A1 - Wochatz, Monique A1 - Engel, Tilman A1 - Schomöller, Anne A1 - Risch, Lucie A1 - Kaplick, Hannes A1 - Mayer, Frank T1 - Characterization of muscle damage and inflammation following repeated maximal eccentric loading of the trunk T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine N2 - Eccentric exercises (ECC) induce reversible muscle damage, delayed-onset muscle soreness and an inflammatory reaction that is often followed by a systemic anti-inflammatory response. Thus, ECC might be beneficial for treatment of metabolic disorders which are frequently accompanied by a low-grade systemic inflammation. However, extent and time course of a systemic immune response after repeated ECC bouts are poorly characterized. PURPOSE: To analyze the (anti-)inflammatory response after repeated ECC loading of the trunk. METHODS: Ten healthy participants (33 ± 6 y; 173 ± 14 cm; 74 ± 16 kg) performed three isokinetic strength measurements of the trunk (concentric (CON), ECC1, ECC2, each 2 wks apart; flexion/extension, velocity 60°/s, 120s MVC). Pre- and 4, 24, 48, 72, 168h post-exercise, muscle soreness (numeric rating scale, NRS) was assessed and blood samples were taken and analyzed [Creatine kinase (CK), C-reactive protein (CRP), Interleukin-6 (IL-6), IL-10, Tumor necrosis factor-α (TNF-α)]. Statistics were done by Friedman‘s test with Dunn‘s post hoc test (α=.05). RESULTS: Mean peak torque was higher during ECC1 (319 ± 142 Nm) than during CON (268 ± 108 Nm; p<.05) and not different between ECC1 and ECC2 (297 ± 126 Nm; p>.05). Markers of muscle damage (peaks post-ECC1: NRS 48h, 4.4±2.9; CK 72h, 14407 ± 19991 U/l) were higher after ECC1 than after CON and ECC2 (p<.05). The responses over 72h (stated as Area under the Curve, AUC) were abolished after ECC2 compared to ECC1 (p<.05) indicating the presence of the repeated bout effect. CRP levels were not changed. IL-6 levels increased 2-fold post-ECC1 (pre: 0.5 ± 0.4 vs. 72h: 1.0 ± 0.8 pg/ml). The IL-6 response was enhanced after ECC1 (AUC 61 ± 37 pg/ml*72h) compared to CON (AUC 33 ± 31 pg/ml*72h; p<.05). After ECC2, the IL-6 response (AUC 43 ± 25 pg/ml*72h) remained lower than post-ECC1, but the difference was not statistically significant. Serum levels of TNF-α and of the anti-inflammatory cytokine IL-10 were below detection limits. Overall, markers of muscle damage and immune response showed high inter-individual variability. CONCLUSION: Despite maximal ECC loading of a large muscle group, no anti-inflammatory and just weak inflammatory responses were detected in healthy adults. Whether ECC elicits a different reaction in inflammatory clinical conditions is unclear. Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000679532.65880.af SN - 0195-9131 SN - 1530-0315 VL - 52 IS - 7S SP - 497 EP - 497 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - GEN A1 - Schomöller, Anne A1 - Risch, Lucie A1 - Kaplick, Hannes A1 - Schraplau, Anne A1 - Wochatz, Monique A1 - Engel, Tilman A1 - Sonnenburg, Dominik A1 - Mayer, Frank T1 - Changes in paraspinal muscle T2 times and creatine kinase after a bout of eccentric exercise T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine N2 - Eccentric (ECC) exercises might cause muscle damage, characterized by delayed-onset muscle soreness, elevated creatine kinase (CK) levels and local muscle oedema, shown by elevated T2 times in magnet resonance imaging (MRI) scans. Previous research suggests a high inter-individual difference regarding these systemic and local responses to eccentric workload. PURPOSE: To analyze ECC exercise-induced muscle damage in lumbar paraspinal muscles assessed via MRI. METHODS: Ten participants (3f/7m; 33±6y; 174±8cm; 71±12kg) were included in the study. Quantitative paraspinal muscle constitution of M. erector spinae and M. multifidius were assessed in supine position before and 72h after an intense eccentric trunk exercise bout in a mobile 1.5 tesla MRI device. MRI scans were recorded on spinal level L3 (T2-weighted TSE echo sequences, 11 slices, 2mm slice thickness, 3mm gap, echo times: 20, 40, 60, 80, 100ms, TR time: 2500ms). Muscle T2 times were calculated for manually traced regions of interest of the respective muscles with an imaging software. The exercise protocol was performed in an isokinetic device and consisted of 120sec alternating ECC trunk flexion-extension with maximal effort. Venous blood samples were taken before and 72h after the ECC exercise. Descriptive statistics (mean±SD) and t-testing for pre-post ECC exercises were performed. RESULTS: T2 times increased from pre- to post-ECC MRI measurements from 55±3ms to 79±28ms in M. erector spinae and from 62±5ms to 78±24ms in M. multifidius (p<0.001). CK increased from 126±97 U/L to 1447±20579 U/L. High SDs of T2 time and CK in post-ECC measures could be due to inter-individual reactions to ECC exercises. 3 participants showed high local and systemic reactions (HR) with T2 time increases of 120±24% (M. erector spinae) and 73±50% (M. multifidius). In comparison, the remaining 7 participants showed increases of 11±12% (M. erector spinae) and 7±9% (M. multifidius) in T2 time. Mean CK increased 9.5-fold in the 3 HR subjects compared with the remaining 7 subjects. CONCLUSIONS: The 120sec maximal ECC trunk flexion-extension protocol induced high amounts of muscle damage in 3 participants. Moderate to low responses were found in the remaining 7 subjects, assuming that inter-individual predictors play a role regarding physiological responses to ECC workload. Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000685648.68626.f1 SN - 0195-9131 SN - 1530-0315 SN - 0025-7990 VL - 52 IS - 17 SP - 929 EP - 929 PB - Lippincott Williams & Wilkins CY - Philadelphia ER -