TY - GEN A1 - Chen, Pan A1 - Bornhorst, Julia A1 - Neely, M. Diana A1 - Avila, Daiana Silva T1 - Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress T2 - Oxidative Medicine and Cellular Longevity Y1 - 2018 U6 - https://doi.org/10.1155/2018/7612172 SN - 1942-0900 SN - 1942-0994 PB - Hindawi CY - London ER - TY - GEN A1 - Steinberg, Pablo T1 - Only one Component of a holistic Nutrition Policy T1 - Nur ein Baustein einer ganzheitlichen Ernährungspolitik T2 - Fleischwirtschaft Y1 - 2018 SN - 0015-363X VL - 98 IS - 11 SP - 8 EP - 9 PB - Deutscher Fachverlag GmbH CY - Frankfurt am Main ER - TY - GEN A1 - Hocher, Berthold A1 - Zeng, Shufei T1 - Need for better PTH assays for clinical research and patient treatment T2 - Clinical chemistry and laboratory medicine : journal of the Forum of the European Societies of Clinical Chemistry - the European Branch of the International Federation of Clinical Chemistry and Laboratory Medicine Y1 - 2017 U6 - https://doi.org/10.1515/cclm-2017-0617 SN - 1434-6621 SN - 1437-4331 VL - 56 IS - 2 SP - 183 EP - 185 PB - De Gruyter CY - Berlin ER - TY - GEN A1 - Honnen, S. A1 - Wellenberg, Anna A1 - Weides, L. A1 - Bornhorst, Julia A1 - Crone, B. A1 - Karst, U. A1 - Fritz, G. T1 - Identification of potent drug candidates for the prevention of cisplatin-induced neurotoxicity in the model organism C. elegans T2 - Naunyn-Schmiedeberg's archives of pharmacology Y1 - 2018 UR - https://link.springer.com/content/pdf/10.1007/s00210-018-1477-5.pdf U6 - https://doi.org/10.1007/s00210-018-1477-5 SN - 0028-1298 SN - 1432-1912 VL - 391 SP - S4 EP - S4 PB - Springer CY - New York ER - TY - GEN A1 - Hocher, Berthold A1 - Zeng, Shufei T1 - Clear the fog around parathyroid hormone assays BT - what do iPTH assays really measure? T2 - Clinical journal of the American Society of Nephrology KW - Assays KW - Biological Assay KW - CKD KW - oxidative stress KW - PTH Y1 - 2018 U6 - https://doi.org/10.2215/CJN.01730218 SN - 1555-9041 SN - 1555-905X VL - 13 IS - 4 SP - 524 EP - 526 PB - American Society of Nephrology CY - Washington ER - TY - GEN A1 - Fernando, Raquel A1 - Drescher, Cathleen A1 - Deubel, Stefanie A1 - Grune, Tilman A1 - Castro, Jose Pedro T1 - Distinct proteasomal activity for fast and slow twitch skeletal muscle during aging T2 - Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research N2 - Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called “fiber switch from fast-to-slow”, we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation. Y1 - 2018 U6 - https://doi.org/10.1016/j.freeradbiomed.2018.04.393 SN - 0891-5849 SN - 1873-4596 VL - 120 SP - S119 EP - S119 PB - Elsevier CY - New York ER - TY - GEN A1 - Schulze, Matthias Bernd A1 - Martinez-Gonzalez, Miguel A. A1 - Fung, Teresa T. A1 - Lichtenstein, Alice H. A1 - Forouhi, Nita G. T1 - Food based dietary patterns and chronic disease prevention T2 - BMJ-British medical journal N2 - Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research directions. Y1 - 2018 U6 - https://doi.org/10.1136/bmj.k2396 SN - 1756-1833 VL - 361 PB - BMJ Publishing Group CY - London ER - TY - GEN A1 - Jamnok, Jutatip A1 - Sanchaisuriya, Kanokwan A1 - Yamsri, Supawadee A1 - Fucharoen, Goonnapa A1 - Fucharoen, Supan A1 - Schweigert, Florian J. A1 - Sanchaisuriya, Pattara T1 - Application of a new portable nephelometer for screening thalassemia in countries with limited resources T2 - International Journal of Laboratory Hematology Y1 - 2018 SN - 1751-5521 SN - 1751-553X VL - 40 SP - 62 EP - 62 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Jamnok, Jutatip A1 - Sanchaisuriya, Kanokwan A1 - Yamsri, Supawadee A1 - Fucharoen, Goonnapa A1 - Fucharoen, Supan A1 - Schweigert, Florian J. A1 - Sanchaisuriya, Pattara T1 - Application of a new portable nephelometer for screening thalassemia in countries with limited resources T2 - International journal of laboratory hematology N2 - One-tube osmotic fragility (OF) test is a rapid test used widely for screening thalassemia in countries with limited resources. The test has important limitation in that its accuracy relies on observers’ experience. The iCheck Turbidity is a prototype of portable nephelometer developed by BioAnalyt (Bioanalyt GmbH, Germany). In this study, we assessed the applicability of the iCheck Turbidity, for checking turbidity of the OF-test Y1 - 2018 SN - 1751-5521 SN - 1751-553X VL - 40 SP - 62 EP - 62 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Kleuser, Burkhard T1 - The enigma of sphingolipids in health and disease T2 - International journal of molecular sciences Y1 - 2018 U6 - https://doi.org/10.3390/ijms19103126 SN - 1422-0067 VL - 19 IS - 10 PB - MDPI CY - Basel ER - TY - GEN A1 - Henze, Andrea T1 - Proteinoxidation als Indikator des Alterungsphänotyps und Target einer individualisierten Ernährungsintervention (ProAID) T1 - Protein Oxidation as an Indicator of the Aging Phenotype and Target of an individualized Nutritional Intervention (ProAID) T2 - Ernährungs-Umschau : Forschung & Praxis N2 - Oxidative posttranslationale Modifikationen endogener Proteine werden v. a. durch reaktive Sauerstoff- und Stickstoffspezies (engl:. Reactive Oxygen Species, ROS, reactive nitrogen species, RNS) hervorgerufen und können sowohl reversibel (z. B. Disulfidbindungen) als auch irreversibel (z. B. Proteincarbonyle) erfolgen [1–3]. Lange wurde angenommen, dass oxidative posttranslationale Proteinmodifikationen (oxPTPM) nur von untergeordneter Bedeutung für den Metabolismus sind. Tatsächlich handelt es sich jedoch um einen physiologischen Prozess, der über die Modulation der Proteinstruktur auch die Proteinfunktion (z. B. Enzymaktivität, Stabilität) und somit zahlreiche Stoffwechselwege wie den Energiestoffwechsel, die Immunfunktion, die vaskuläre Funktion sowie Apoptose und Genexpression beeinflussen kann. Die Bildung von oxPTPM ist dabei hochreguliert und hängt u. a. von der Proteinstruktur, der Verfügbarkeit von ROS und RNS sowie dem lokalen Mikromilieu der Zelle ab [2, 4]. Y1 - 2018 SN - 0174-0008 VL - 65 IS - 10 SP - M566 EP - M567 PB - Umschau-Zeitschriftenverl. CY - Frankfurt, Main ER - TY - GEN A1 - Uhlig, Katja A1 - Gehre, Christian P. A1 - Kammerer, Sarah A1 - Küpper, Jan-Heiner A1 - Coleman, Charles Dominic A1 - Püschel, Gerhard Paul A1 - Duschl, Claus T1 - Real-time monitoring of oxygen consumption of hepatocytes in a microbioreactor T2 - Toxicology letters Y1 - 2018 U6 - https://doi.org/10.1016/j.toxlet.2018.06.652 SN - 0378-4274 SN - 1879-3169 VL - 295 SP - S115 EP - S115 PB - Elsevier CY - Clare ER -