TY - JOUR A1 - Baier, Heiko A1 - Kelling, Alexandra A1 - Jackstell, Ralf A1 - Holdt, Hans-Jürgen T1 - Rhodium(I) and Silver(I) Complexes of 4,5-Dicyano-1,3-dimesityl- and 4,5-Dicyano-1,3-dineopentylimidazol-2-ylidene JF - Zeitschrift für anorganische und allgemeine Chemie N2 - The new N-heterocyclic carbene (NHC) precursors 4,5-dicyano-1, -dimesityl- (9) and 4, 5-dicyano-1, 3-dineopentyl-2-(pentafluorophenyl)imidazoline (14) were synthesized. 9 could be determined by X-ray crystallography. With the 2-pentafluorophenyl-substituted imidazolines 9 and 14, the [AgCl(NHC)], [RhCl(COD)(NHC)], and [RhCl(CO)(2)(NHC)] complexes [NHC = 4, 5-dicyano-1, 3-dimesitylimidazol-2-ylidene (3) and 4, 5-dicyano-1, 3-dineopentylimidazol-2-ylidene (4)] were obtained. Crystal structures of [AgCl(3)] (15), [RhCl(COD)(3)] (17), [RhCl(COD)(4)] (18), and [RhCl(CO)(2)(3)] (19) were solved and with the crystal data of 19, the percent buried volume (%V-bur) of 31.8(+/- 0.1)% was determined for NHC 3. Infrared spectra of the imidazolines 9 and 14 and of the complexes 15-20 were recorded and the CO stretching frequencies of complexes 19 and 20 were used to determine the 3 ( (-1)) and 4 ( (-1)), thus proving that 1, 3-substitution of maleonitrile-NHCs does not have a significant effect for the high -acceptor strength of these carbenes. KW - Carbenes KW - Rhodium KW - Silver KW - Crystal structure KW - Diaminomaleonitrile Y1 - 2013 U6 - https://doi.org/10.1002/zaac.201300250 SN - 0044-2313 SN - 1521-3749 VL - 639 IS - 10 SP - 1731 EP - 1739 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bailleul, Frederic A1 - Grimm, Volker A1 - Chion, Clement A1 - Hammill, Mike T1 - Modeling implications of food resource aggregation on animal migration phenology JF - Ecology and evolution N2 - The distribution of poikilotherms is determined by the thermal structure of the marine environment that they are exposed to. Recent research has indicated that changes in migration phenology of beluga whales in the Arctic are triggered by changes in the thermal structure of the marine environment in their summering area. If sea temperatures reflect the spatial distribution of food resources, then changes in the thermal regime will affect how homogeneous or clumped food is distributed. We explore, by individual-based modelling, the hypothesis that changes in migration phenology are not necessarily or exclusively triggered by changes in food abundance, but also by changes in the spatial aggregation of food. We found that the level of food aggregation can significantly affect the relationship between the timing of the start of migration to the winter grounds and the total prey capture of individuals. Our approach strongly indicates that changes in the spatial distribution of food resources should be considered for understanding and quantitatively predicting changes in the phenology of animal migration. KW - Animal migration KW - food structuring KW - global change KW - individual-based model KW - polar environment Y1 - 2013 U6 - https://doi.org/10.1002/ece3.656 SN - 2045-7758 VL - 3 IS - 8 SP - 2535 EP - 2546 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Baillot, Anne T1 - Kommunikation Y1 - 2013 SN - 978-3-8353-1255-5 ER - TY - JOUR A1 - Balderjahn, Ingo A1 - Buerke, Anja A1 - Kirchgeorg, Manfred A1 - Peyer, Mathias A1 - Seegebarth, Barbara A1 - Wiedmann, Klaus-Peter T1 - Consciousness for sustainable consumption : scale development and new insights in the economic dimension of consumers’ sustainability JF - AMS review : official publication of the Academy of Marketing Scienc N2 - The “triple bottom line” concept (planet, people, and profit) represents an important guideline for the sustainable, hence future-oriented, development of societies and for the behaviors of all societal members. For institutions promoting societal change, as well as for companies being confronted with growing expectations regarding compelling contributions to sustainable changes, it is of great importance to know if, and to what extent, consumers have already internalized the idea of sustainability. Against the background of existing research gaps regarding a comprehensive measurement of the consciousness for sustainable consumption (CSC), the authors present the result of a scale development. Consciousness was operationalized by weighting personal beliefs with the importance attached by consumers to sustainability dimensions. Four separate tests of the CSC scale indicated an appropriate psychometric quality of the scale and provided support for this new measurement approach that incorporates the environmental, social and economic dimensions of sustainability. KW - Sustainability KW - Consciousness for sustainable consumption KW - Scale development Y1 - 2013 U6 - https://doi.org/10.1007/s13162-013-0057-6 SN - 1869-814X SN - 1869-8182 VL - 3 IS - 4 SP - 181 EP - 192 PB - Springer CY - New York ER - TY - JOUR A1 - Balderjahn, Ingo A1 - Peyer, Mathias A1 - Paulssen, Marcel T1 - Consciousness for fair consumption : conceptualization, scale development and empirical validation JF - International Journal of Consumer Studies N2 - Sustainable consumption means that consumers act in an environmentally and socially responsible manner. Compared with the vast amount of studies concerning environmentally conscious consumer behaviour, relatively little is known about socially conscious consumption. The present paper focuses on fair consumption as an important aspect of social consumption. In our study, consciousness for fair consumption (CFC) is defined as a latent disposition of consumers to prefer products that are produced and traded in compliance with fair labour and business practices. A scale to measure CFC was conceptualized and tested in three independent empirical studies. Two studies were conducted at European universities (2010 and 2012) and used 352 and 362 undergraduate business students respectively. The third study, conducted in 2011, used 141 employees at a European university. The results confirmed the reliability and validity of the new CFC scale across samples. While being moderately related to other aspects of sustainable consumption such as ecological concern and moral reasoning, CFC was significantly distinct from those concepts. Most importantly, it was established that the CFC, as measured by the new CFC scale, is a strong determinant of consumption of fair trade products that has been neglected in existing research. Y1 - 2013 U6 - https://doi.org/10.1111/ijcs.12030 SN - 1470-6431 SN - 1470-6423 VL - 37 IS - 5 SP - 546 EP - 555 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Balderjahn, Ingo A1 - Peyer, Mathias A1 - Paulssen, Marcel T1 - Consciousness for fair consumption - conceptualization, scale development and empirical validation JF - International journal of consumer studies N2 - Sustainable consumption means that consumers act in an environmentally and socially responsible manner. Compared with the vast amount of studies concerning environmentally conscious consumer behaviour, relatively little is known about socially conscious consumption. The present paper focuses on fair consumption as an important aspect of social consumption. In our study, consciousness for fair consumption (CFC) is defined as a latent disposition of consumers to prefer products that are produced and traded in compliance with fair labour and business practices. A scale to measure CFC was conceptualized and tested in three independent empirical studies. Two studies were conducted at European universities (2010 and 2012) and used 352 and 362 undergraduate business students respectively. The third study, conducted in 2011, used 141 employees at a European university. The results confirmed the reliability and validity of the new CFC scale across samples. While being moderately related to other aspects of sustainable consumption such as ecological concern and moral reasoning, CFC was significantly distinct from those concepts. Most importantly, it was established that the CFC, as measured by the new CFC scale, is a strong determinant of consumption of fair trade products that has been neglected in existing research. KW - Sustainable consumption KW - socially conscious consumption KW - consciousness for fair consumption KW - scale development KW - fair trade Y1 - 2013 U6 - https://doi.org/10.1111/ijcs.12030 SN - 1470-6423 VL - 37 IS - 5 SP - 546 EP - 555 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Balderjahn, Ingo A1 - Silbermann, Alexandra T1 - Die Rolle der Selbstaufmerksamkeit beim Bewusstsein für einen gesunden Konsum : Überblick und Konzeptentwicklung JF - International Journal of Marketing : IJM Y1 - 2013 SN - 2306-7217 VL - 52 IS - 1 SP - 37 EP - 48 PB - Verlag Österreich CY - Wien ER - TY - JOUR A1 - Ballato, Paolo A1 - Stockli, Daniel F. A1 - Ghassemi, Mohammad R. A1 - Landgraf, Angela A1 - Strecker, Manfred A1 - Hassanzadeh, Jamshid A1 - Friedrich, Anke M. A1 - Tabatabaei, Saeid H. T1 - Accommodation of transpressional strain in the Arabia-Eurasia collision zone new constraints from (U-Th)/He thermochronology in the Alborz mountains, north Iran JF - Tectonics N2 - The Alborz range of N Iran provides key information on the spatiotemporal evolution and characteristics of the Arabia-Eurasia continental collision zone. The southwestern Alborz range constitutes a transpressional duplex, which accommodates oblique shortening between Central Iran and the South Caspian Basin. The duplex comprises NW-striking frontal ramps that are kinematically linked to inherited E-W-striking, right-stepping lateral to obliquely oriented ramps. New zircon and apatite (U-Th)/He data provide a high-resolution framework to unravel the evolution of collisional tectonics in this region. Our data record two pulses of fast cooling associated with SW-directed thrusting across the frontal ramps at similar to 18-14 and 9.5-7.5 Ma, resulting in the tectonic repetition of a fossil zircon partial retention zone and a cooling pattern with a half U-shaped geometry. Uniform cooling ages of similar to 7-6 Ma along the southernmost E-W striking oblique ramp and across its associated NW-striking frontal ramps suggests that the ramp was reactivated as a master throughgoing, N-dipping thrust. We interpret this major change in fault kinematics and deformation style to be related to a change in the shortening direction from NE to N/NNE. The reduction in the obliquity of thrusting may indicate the termination of strike-slip faulting (and possibly thrusting) across the Iranian Plateau, which could have been triggered by an increase in elevation. Furthermore, we suggest that similar to 7-6-m.y.-old S-directed thrusting predated inception of the westward motion of the South Caspian Basin. Citation: Ballato, P., D. F. Stockli, M. R. Ghassemi, A. Landgraf, M. R. Strecker, J. Hassanzadeh, A. Friedrich, and S. H. Tabatabaei (2012), Accommodation of transpressional strain in the Arabia-Eurasia collision zone: new constraints from (U-Th)/He thermochronology in the Alborz mountains. Y1 - 2013 U6 - https://doi.org/10.1029/2012TC003159 SN - 0278-7407 VL - 32 IS - 1 SP - 1 EP - 18 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Balling, Philipp A1 - Maystrenko, Yuriy A1 - Scheck-Wenderoth, Magdalena T1 - The deep thermal field of the Glückstadt Graben JF - Environmental earth sciences N2 - With this paper, we assess the present-day conductive thermal field of the Glueckstadt Graben in NW Germany that is characterized by large salt walls and diapirs structuring the graben fill. We use a finite element method to calculate the 3D steady-state conductive thermal field based on a lithosphere-scale 3D structural model that resolves the first-order structural characteristics of the graben and its underlying lithosphere. Model predictions are validated against measured temperatures in six deep wells. Our investigations show that the interaction of thickness distributions and thermal rock properties of the different geological layers is of major importance for the distribution of temperatures in the deep subsurface of the Glueckstadt Graben. However, the local temperatures may result from the superposed effects of different controlling factors. Especially, the upper sedimentary part of the model exhibits huge lateral temperature variations, which correlate spatially with the shape of the thermally highly conductive Permian salt layer. Variations in thickness and geometry of the salt cause two major effects, which provoke considerable lateral temperature variations for a given depth. (1) The "chimney effect" causes more efficient heat transport within salt diapirs. As a consequence positive thermal anomalies develop in the upper part and above salt structures, where the latter are covered by much less conductive sediments. In contrast, negative thermal anomalies are noticeable underneath salt structures. (2) The "thermal blanketing effect" is caused by thermally low conductive sediments that provoke the local storage of heat where these insulating sediments are present. The latter effect leads to both local and regional thermal anomalies. Locally, this translates to higher temperatures where salt margin synclines are filled with thick insulating clastic sediments. For the regional anomalies the cumulative insulating effects of the entire sediment fill results in a long-wavelength variation of temperatures in response to heat refraction effects caused by the contrast between insulating sediments and highly conductive crystalline crust. Finally, the longest wavelength of temperature variations is caused by the depth position of the isothermal lithosphere-asthenosphere boundary defining the regional variations of the overall geothermal gradient. We find that a conductive thermal model predicts observed temperatures reasonably well for five of the six available wells, whereas the steady-state conductive approach appears not to be valid for the sixth well. KW - Conductive thermal field KW - 3D thermal modelling KW - Zechstein salt KW - Lithosphereasthenosphere boundary KW - Schleswig-Holstein KW - Glueckstadtgraben Y1 - 2013 U6 - https://doi.org/10.1007/s12665-013-2750-z SN - 1866-6280 SN - 1866-6299 VL - 70 IS - 8 SP - 3505 EP - 3522 PB - Springer CY - New York ER - TY - JOUR A1 - Banbara, Mutsunori A1 - Soh, Takehide A1 - Tamura, Naoyuki A1 - Inoue, Katsumi A1 - Schaub, Torsten H. T1 - Answer set programming as a modeling language for course timetabling JF - Theory and practice of logic programming N2 - The course timetabling problem can be generally defined as the task of assigning a number of lectures to a limited set of timeslots and rooms, subject to a given set of hard and soft constraints. The modeling language for course timetabling is required to be expressive enough to specify a wide variety of soft constraints and objective functions. Furthermore, the resulting encoding is required to be extensible for capturing new constraints and for switching them between hard and soft, and to be flexible enough to deal with different formulations. In this paper, we propose to make effective use of ASP as a modeling language for course timetabling. We show that our ASP-based approach can naturally satisfy the above requirements, through an ASP encoding of the curriculum-based course timetabling problem proposed in the third track of the second international timetabling competition (ITC-2007). Our encoding is compact and human-readable, since each constraint is individually expressed by either one or two rules. Each hard constraint is expressed by using integrity constraints and aggregates of ASP. Each soft constraint S is expressed by rules in which the head is the form of penalty (S, V, C), and a violation V and its penalty cost C are detected and calculated respectively in the body. We carried out experiments on four different benchmark sets with five different formulations. We succeeded either in improving the bounds or producing the same bounds for many combinations of problem instances and formulations, compared with the previous best known bounds. KW - answer set programming KW - educational timetabling KW - course timetabling Y1 - 2013 U6 - https://doi.org/10.1017/S1471068413000495 SN - 1471-0684 VL - 13 IS - 2 SP - 783 EP - 798 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Barbosa Pfannes, Eva Katharina A1 - Anielski, Alexander A1 - Gerhardt, Matthias A1 - Beta, Carsten T1 - Intracellular photoactivation of caged cGMP induces myosin II and actin responses in motile cells JF - Integrative biology N2 - Cyclic GMP (cGMP) is a ubiquitous second messenger in eukaryotic cells. It is assumed to regulate the association of myosin II with the cytoskeleton of motile cells. When cells of the social amoeba Dictyostelium discoideum are exposed to chemoattractants or to increased osmotic stress, intracellular cGMP levels rise, preceding the accumulation of myosin II in the cell cortex. To directly investigate the impact of intracellular cGMP on cytoskeletal dynamics in a living cell, we released cGMP inside the cell by laser-induced photo-cleavage of a caged precursor. With this approach, we could directly show in a live cell experiment that an increase in intracellular cGMP indeed induces myosin II to accumulate in the cortex. Unexpectedly, we observed for the first time that also the amount of filamentous actin in the cell cortex increases upon a rise in the cGMP concentration, independently of cAMP receptor activation and signaling. We discuss our results in the light of recent work on the cGMP signaling pathway and suggest possible links between cGMP signaling and the actin system. Y1 - 2013 U6 - https://doi.org/10.1039/c3ib40109j SN - 1757-9694 SN - 1757-9708 VL - 5 IS - 12 SP - 1456 EP - 1463 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Baroni, Gabriele A1 - Ortuani, B. A1 - Facchi, A. A1 - Gandolfi, C. T1 - The role of vegetation and soil properties on the spatio-temporal variability of the surface soil moisture in a maize-cropped field JF - Journal of hydrology N2 - Soil moisture dynamics are affected by complex interactions among several factors. Understanding the relative importance of these factors is still an important challenge in the study of water fluxes and solute transport in unsaturated media. In this study, the spatio-temporal variability of surface soil moisture was investigated in a 10 ha flat cropped field located in northern Italy. Soil moisture was measured on a regular 50 x 50 m grid on seven dates during the growing season. For each measurement campaign, the spatial variability of the soil moisture was compared with the spatial variability of the soil texture and crop properties. In particular, to better understand the role of the vegetation, the spatio-temporal variability of two different parameters - leaf area index and crop height - was monitored on eight dates at different crop development stages. Statistical and geostatistical analysis was then applied to explore the interactions between these variables. In agreement with other studies, the results show that the soil moisture variability changes according to the average value within the field, with the standard deviation reaching a maximum value under intermediate mean soil moisture conditions and the coefficient of variation decreasing exponentially with increasing mean soil moisture. The controls of soil moisture variability change according to the average soil moisture within the field. Under wet conditions, the spatial distribution of the soil moisture reflects the variability of the soil texture. Under dry conditions, the spatial distribution of the soil moisture is affected mostly by the spatial variability of the vegetation. The interaction between these two factors is more important under intermediate soil moisture conditions. These results confirm the importance of considering the average soil moisture conditions within a field when investigating the controls affecting the spatial variability of soil moisture. This study highlights the importance of considering the spatio-temporal variability of the vegetation in investigating soil moisture dynamics, especially under intermediate and dry soil moisture conditions. The results of this study have important implications in different hydrological applications, such as for sampling design, ranking stability application, indirect measurements of soil properties and model parameterisation. KW - Soil moisture KW - Spatio-temporal variability KW - Controlling factors KW - Principal component analysis KW - Geostatistics KW - Agricultural field Y1 - 2013 U6 - https://doi.org/10.1016/j.jhydrol.2013.03.007 SN - 0022-1694 SN - 1879-2707 VL - 489 IS - 7 SP - 148 EP - 159 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Barthelme, Simon A1 - Trukenbrod, Hans Arne A1 - Engbert, Ralf A1 - Wichmann, Felix A. T1 - Modeling fixation locations using spatial point processes JF - Journal of vision N2 - Whenever eye movements are measured, a central part of the analysis has to do with where subjects fixate and why they fixated where they fixated. To a first approximation, a set of fixations can be viewed as a set of points in space; this implies that fixations are spatial data and that the analysis of fixation locations can be beneficially thought of as a spatial statistics problem. We argue that thinking of fixation locations as arising from point processes is a very fruitful framework for eye-movement data, helping turn qualitative questions into quantitative ones. We provide a tutorial introduction to some of the main ideas of the field of spatial statistics, focusing especially on spatial Poisson processes. We show how point processes help relate image properties to fixation locations. In particular we show how point processes naturally express the idea that image features' predictability for fixations may vary from one image to another. We review other methods of analysis used in the literature, show how they relate to point process theory, and argue that thinking in terms of point processes substantially extends the range of analyses that can be performed and clarify their interpretation. KW - eye movements KW - fixation locations KW - saliency KW - modeling KW - point process KW - spatial statistics Y1 - 2013 U6 - https://doi.org/10.1167/13.12.1 SN - 1534-7362 VL - 13 IS - 12 PB - Association for Research in Vision and Opthalmology CY - Rockville ER - TY - JOUR A1 - Barthold, Frauke Katrin A1 - Wiesmeier, Martin A1 - Breuer, L. A1 - Frede, Hans-Georg A1 - Wu, J. A1 - Blank, F. Benjamin T1 - Land use and climate control the spatial distribution of soil types in the grasslands of Inner Mongolia JF - Journal of arid environments N2 - The spatial distribution of soil types is controlled by a set of environmental factors such as climate, organisms, parent material and topography as well as time and space. A change of these factors will lead to a change in the spatial distribution of soil types. In this study, we use a digital soil mapping approach to improve our knowledge about major soil type distributing factors in the steppe regions of Inner Mongolia (China) which currently undergo tremendous environmental change, e.g. climate and land use change. We use Random Forests in an effort to map Reference Soil Groups according to the World Reference Base for Soil Resources (WRB) in the Xilin River catchment. We benefit from the superior prediction capabilities of RF and additional interpretive results in order to identify the major environmental factors that control spatial patterns of soil types. The nine WRB soil groups that were identified and spatially predicted for the study area are Arenosol, Calcisol, Cambisol, Chernozem, Cryosol, Gleysol, Kastanozem, Phaeozem and Regosol. Model and prediction performances of the RF model are high with an Out-of-Bag error of 51.6% for the model and a misclassification error for the predicted map of 28.9%. The main controlling factors of soil type distribution are land use, a set of topographic variables, geology and climate. However, land use and climate are of major importance and topography and geology are of minor importance. The visualizations of the predictions, the variable importance measures as result of RF and the comparisons of these with the spatial distribution of the environmental factors delivered additional, quantitative information of these controlling factors and revealed that intensively grazed areas are subjected to soil degradation. However, most of the area is still governed by natural soil forming processes which are driven by climate, topography and geology. Most importantly though, our study revealed that a shift towards warmer temperatures and lower precipitation regimes will lead to a change of the spatial distribution of RSGs towards steppe soils that store less carbon, i.e. a decrease of spatial extent of Phaeozems and an increase of spatial extent of Chernozems and Kastanozems. KW - Random Forests KW - Soil-environmental relationships KW - Steppe KW - Inner Mongolia KW - Land use change KW - Climate change Y1 - 2013 U6 - https://doi.org/10.1016/j.jaridenv.2012.08.004 SN - 0140-1963 VL - 88 IS - 1 SP - 194 EP - 205 PB - Elsevier CY - London ER - TY - JOUR A1 - Basel, Nicolai A1 - Harms, Ute A1 - Prechtl, Helmut T1 - Analysis of students' arguments on evolutionary theory JF - Journal of biological education N2 - A qualitative exploratory study was conducted to reveal students' argumentation skills in the context of the topic of evolution. Transcripts from problem-centred interviews on secondary students' beliefs about evolutionary processes of adaptation were analysed using a content analysis approach. For this purpose two categorical systems were deductively developed: one addressing the complexity of students' arguments, the other focusing on students' use of argumentation schemes. Subsequently, the categorical systems were inductively elaborated upon the basis of the analysed material showing a satisfactory inter-rater reliability. Regarding the arguments' complexity, students produced mainly single claims or claims with a single justification consisting of either data or warrants. With regard to argumentation schemes students drew their arguments mainly using causal schemes, analogies, or illustrative examples. Results are discussed in light of possible implications for teaching evolutionary theory using classroom argumentation. KW - evolutionary theory KW - reasoning KW - argumentation KW - argumentation schemes Y1 - 2013 U6 - https://doi.org/10.1080/00219266.2013.799078 SN - 0021-9266 SN - 2157-6009 VL - 47 IS - 4 SP - 192 EP - 199 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Basso, Heitor Cury A1 - Monteiro, Jose Roberto B. de A. A1 - Mazulquim, Daniel Baladelli A1 - de Paula, Geyverson Teixeira A1 - Goncalves Neto, Luiz A1 - Gerhard, Reimund T1 - Alternating current-generated plasma discharges for the controlled direct current charging of ferroelectrets JF - Journal of applied physics N2 - The standard charging process for polymer ferroelectrets, e. g., from polypropylene foams or layered film systems involves the application of high DC fields either to metal electrodes or via a corona discharge. In this often-used process, the DC field triggers the internal breakdown and limits the final charge densities inside the ferroelectret cavities and, thus, the final polarization. Here, an AC + DC charging procedure is proposed and demonstrated in which a high-voltage high-frequency (HV-HF) wave train is applied together with a DC poling voltage. Thus, the internal dielectric-barrier discharges in the ferroelectret cavities are induced by the HV-HF wave train, while the final charge and polarization level is controlled separately through the applied DC voltage. In the new process, the frequency and the amplitude of the HV-HF wave train must be kept within critical boundaries that are closely related to the characteristics of the respective ferroelectrets. The charging method has been tested and investigated on a fluoropolymer-film system with a single well-defined cylindrical cavity. It is found that the internal electrical polarization of the cavity can be easily controlled and increases linearly with the applied DC voltage up to the breakdown voltage of the cavity. In the standard charging method, however, the DC voltage would have to be chosen above the respective breakdown voltage. With the new method, control of the HV-HF wave-train duration prevents a plasma-induced deterioration of the polymer surfaces inside the cavities. It is observed that the frequency of the HV-HF wave train during ferroelectret charging and the temperature applied during poling of ferroelectrics serve an analogous purpose. The analogy and the similarities between the proposed ferroelectret charging method and the poling of ferroelectric materials or dipole electrets at elevated temperatures with subsequent cooling under field are discussed. Y1 - 2013 U6 - https://doi.org/10.1063/1.4821113 SN - 0021-8979 SN - 1089-7550 VL - 114 IS - 10 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Basso, Heitor Cury A1 - Qiu, Xunlin A1 - Wirges, Werner A1 - Gerhard, Reimund T1 - Temporal evolution of the re-breakdown voltage in small gaps from nanoseconds to milliseconds JF - Applied physics letters N2 - A detailed understanding of electric breakdown in dielectrics is of scientific and technological interest. In gaseous dielectrics, a so-called re-breakdown is sometimes observed after extinction of the previous discharge. Although time-dependent re-breakdown voltage is essentially known, its behavior immediately after the previous discharge is not precisely understood. We present an electronic circuit for accurate measurements of the time-dependent re-breakdown voltage in small gaps from tens of nanoseconds to several milliseconds after the previous spark. Results from such experiments are compared with earlier findings, and relevant physical mechanisms such as heating of the gas, decay of the plasma, and ionization of excited atoms and molecules are discussed. It is confirmed that the thermal model is not valid at times below several microseconds. Y1 - 2013 U6 - https://doi.org/10.1063/1.4773518 SN - 0003-6951 VL - 102 IS - 1 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Bathke, Hannes A1 - Sudhaus, Henriette A1 - Holohan, E. P. A1 - Walter, T. R. A1 - Shirzaei, M. T1 - An active ring fault detected at Tendurek volcano by using InSAR JF - JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH N2 - Although ring faults are present at many ancient, deeply eroded volcanoes, they have been detected at only very few modern volcanic centers. At the so far little studied Tendurek volcano in eastern Turkey, we generated an ascending and a descending InSAR time series of its surface displacement field for the period from 2003 to 2010. We detected a large (similar to 105km(2)) region that underwent subsidence at the rate of similar to 1cm/yr during this period. Source modeling results show that the observed signal fits best to simulations of a near-horizontal contracting sill located at around 4.5km below the volcano summit. Intriguingly, the residual displacement velocity field contains a steep gradient that systematically follows a system of arcuate fractures visible on the volcano’s midflanks. RapidEye satellite optical images show that this fracture system has deflected Holocene lava flows, thus indicating its presence for at least several millennia. We interpret the arcuate fracture system as the surface expression of an inherited ring fault that has been slowly reactivated during the detected recent subsidence. These results show that volcano ring faults may not only slip rapidly during eruptive or intrusive phases, but also slowly during dormant phases. KW - Tendurek volcano KW - caldera subsidence KW - arcuate fracture system KW - fault reactivation Y1 - 2013 U6 - https://doi.org/10.1002/jgrb.50305 SN - 2169-9313 VL - 118 IS - 8 SP - 4488 EP - 4502 PB - AMER GEOPHYSICAL UNION CY - WASHINGTON ER - TY - JOUR A1 - Bauer, Barbara A1 - Sommer, Ulrich A1 - Gaedke, Ursula T1 - High predictability of spring phytoplankton biomass in mesocosms at the species, functional group and community level JF - Freshwater biology N2 - 1. Models aim to predict phytoplankton dynamics based on observed initial conditions and a set of equations and parameters. However, our knowledge about initial conditions in nature is never perfect. Thus, if phytoplankton dynamics are sensitive to small variations in initial conditions, they are difficult to predict. 2. We used time-series data from indoor mesocosm experiments with natural phyto- and zooplankton communities to quantify the extent to which small initial differences in the species, functional group and community biomass in parallel treatments were amplified or buffered over time. We compared the differences in dynamics between replicates and among all mesocosms of 1year. 3. Temperature-sensitive grazing during the exponential growth phase of phytoplankton caused divergence. In contrast, negative density dependence caused convergence. 4. Mean differences in biomass between replicates were similar for all hierarchical levels. This indicates that differences in their initial conditions were amplified to the same extent. Even though large differences in biomass occasionally occurred between replicates for a short time, dynamics returned to the same path at all hierarchical levels. This suggests that internal feedback mechanisms make the spring development of phytoplankton highly predictable. KW - divergence KW - hierarchical level KW - mesocosms KW - predictability KW - replicates Y1 - 2013 U6 - https://doi.org/10.1111/j.1365-2427.2012.02780.x SN - 0046-5070 VL - 58 IS - 3 SP - 588 EP - 596 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Bauer, Maximilian A1 - Metzler, Ralf T1 - In vivo facilitated diffusion model JF - PLoS one N2 - Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed. Here we use a simple model for the bacterial genome inside the cell and present a semi-analytical model for the in vivo target search of transcription factors within the facilitated diffusion framework. Without having to resort to extensive simulations we determine the mean search time of a lac repressor in a living E. coli cell by including parameters deduced from experimental measurements. The results agree very well with experimental findings, and thus the facilitated diffusion picture emerges as a quantitative approach to gene regulation in living bacteria cells. Furthermore we see that the search time is not very sensitive to the parameters characterizing the DNA configuration and that the cell seems to operate very close to optimal conditions for target localization. Local searches as implied by the colocalization mechanism are only found to mildly accelerate the mean search time within our model. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0053956 SN - 1932-6203 VL - 8 IS - 1 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Baumann, Annette A1 - Lucas, Reeh T1 - Folgende Module könnten Sie auch interessieren? JF - E-Learning Symposium 2012 : Aktuelle Anwendungen, innovative Prozesse und neueste Ergebnisse aus der E-Learning-Praxis ; Potsdam, 17. November 2012 N2 - Im Hochschulalltag begegnen sich Dozenten und Studenten als zwei Gruppen mit entgegengesetzten Rollen, z.B. als Lehrende und Lernende, als Forscher und studentische Hilfskräfte. Die Berührungspunkte beider Gruppen eröffnen neue Chancen im Student Life Cycle für zielgerichtete Kooperationen – von der Studierende für Entscheidungsprozesse im Fortgang ihres Studiums und Dozenten für die Gewinnung von Masterstudenten und Doktoranden profitieren können. Kein E-Learning im klassischen Sinn, aber eine praktische Anwendung von Empfehlungstechniken auf Basis eines Campus Management Systems werden Posterbeitrag und Live-Demo vorstellen, mit der zur Zeit verschiedene Zielrichtungen für die Empfehlung von Wahlmodulen und eine kohorten-basierte Informationsaufbereitung im Curricula Support experimentell untersucht werden. Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442157 SP - 67 EP - 68 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Baumann, Otto A1 - Bauer, Alexandra T1 - Development of apical membrane organization and V-ATPase regulation in blowfly salivary glands JF - The journal of experimental biology N2 - Secretory cells in blowfly salivary gland are specialized via morphological and physiological attributes in order to serve their main function, i.e. the transport of solutes at a high rate in response to a hormonal stimulus, namely serotonin (5-HT). This study examines the way that 5-HT-insensitive precursor cells differentiate into morphologically complex 5-HT-responsive secretory cells. By means of immunofluorescence microscopy, immunoblotting and measurements of the transepithelial potential changes, we show the following. (1) The apical membrane of the secretory cells becomes organized into an elaborate system of canaliculi and is folded into pleats during the last pupal day and the first day of adulthood. (2) The structural reorganization of the apical membrane is accompanied by an enrichment of actin filaments and phosphorylated ERM protein (phospho-moesin) at this membrane domain and by the deployment of the membrane-integral part of vacuolar-type H+-ATPase (V-ATPase). These findings suggest a role for phospho-moesin, a linker between actin filaments and membrane components, in apical membrane morphogenesis. (3) The assembly and activation of V-ATPase can be induced immediately after eclosion by way of 8-CPT-cAMP, a membrane-permeant cAMP analogue. (4) 5-HT, however, produces the assembly and activation of V-ATPase only in flies aged for at least 2 h after eclosion, indicating that, at eclosion, the 5-HT receptor/adenylyl cyclase/cAMP signalling pathway is inoperative upstream of cAMP. (5) 5-HT activates both the Ca2+ signalling pathway and the cAMP signalling cascade in fully differentiated secretory cells. However, the functionality of these signalling cascades does not seem to be established in a tightly coordinated manner during cell differentation. KW - secretory cell KW - moesin KW - morphogenesis KW - serotonin KW - vacuolar ATPase KW - cAMP Y1 - 2013 U6 - https://doi.org/10.1242/jeb.077420 SN - 0022-0949 VL - 216 IS - 7 SP - 1225 EP - 1234 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Baumann, Tobias A1 - Arndt, Katja Maren A1 - Müller, Kristian M. T1 - Directional cloning of DNA fragments using deoxyinosine-containing oligonucleotides and endonuclease V JF - BMC biotechnology N2 - Background: DNA fragments carrying internal recognition sites for the restriction endonucleases intended for cloning into a target plasmid pose a challenge for conventional cloning. Results: A method for directional insertion of DNA fragments into plasmid vectors has been developed. The target sequence is amplified from a template DNA sample by PCR using two oligonucleotides each containing a single deoxyinosine base at the third position from the 5' end. Treatment of such PCR products with endonuclease V generates 3' protruding ends suitable for ligation with vector fragments created by conventional restriction endonuclease reactions. Conclusions: The developed approach generates terminal cohesive ends without the use of Type II restriction endonucleases, and is thus independent from the DNA sequence. Due to PCR amplification, minimal amounts of template DNA are required. Using the robust Taq enzyme or a proofreading Pfu DNA polymerase mutant, the method is applicable to a broad range of insert sequences. Appropriate primer design enables direct incorporation of terminal DNA sequence modifications such as tag addition, insertions, deletions and mutations into the cloning strategy. Further, the restriction sites of the target plasmid can be either retained or removed. KW - Cohesive ends KW - DNA cleavage KW - Genetic vectors KW - Modified primers KW - Molecular methods KW - Polymerase chain reaction KW - Recombinant Escherichia coli KW - Restriction enzymes Y1 - 2013 U6 - https://doi.org/10.1186/1472-6750-13-81 SN - 1472-6750 VL - 13 IS - 10 PB - BioMed Central CY - London ER - TY - JOUR A1 - Baushev, Anton N. T1 - Extragalactic dark matter and direct detection experiments JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - Recent astronomical data strongly suggest that a significant part of the dark matter content of the Local Group and Virgo Supercluster is not incorporated into the galaxy halos and forms diffuse components of these galaxy clusters. A portion of the particles from these components may penetrate the Milky Way and make an extragalactic contribution to the total dark matter containment of our Galaxy. We find that the particles of the diffuse component of the Local Group are apt to contribute similar to 12% to the total dark matter density near Earth. The particles of the extragalactic dark matter stand out because of their high speed (similar to 600 km s(-1)), i.e., they are much faster than the galactic dark matter. In addition, their speed distribution is very narrow (similar to 20 km s(-1)). The particles have an isotropic velocity distribution (perhaps, in contrast to the galactic dark matter). The extragalactic dark matter should provide a significant contribution to the direct detection signal. If the detector is sensitive only to the fast particles (v > 450 km s(-1)), then the signal may even dominate. The density of other possible types of the extragalactic dark matter (for instance, of the diffuse component of the Virgo Supercluster) should be relatively small and comparable with the average dark matter density of the universe. However, these particles can generate anomaly high-energy collisions in direct dark matter detectors. KW - astroparticle physics KW - dark matter KW - elementary particles KW - Local Group Y1 - 2013 U6 - https://doi.org/10.1088/0004-637X/771/2/117 SN - 0004-637X VL - 771 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Bechtold, Sander A1 - Hogendoorn, Thirza A1 - Kohútová, Vivien A1 - Potočanová, Katarína T1 - Deepening understanding JF - Potsdamer geographische Praxis N2 - 1. Key concepts 2. What students should have done 3. What students did 4. Deepening understanding 5. General description of deepening understanding 6. Why is deepening understanding an important stage? 7. How does deepening understanding occur in the lessons and some examples 8. Possible difficulties 9. Conclusion KW - Europäische Werteerziehung KW - Familie KW - Lehrevaluation KW - Studierendenaustausch KW - Unterrichtseinheiten KW - Curriculum Framework KW - European values education KW - Family KW - lesson evaluation KW - student exchange KW - teaching units KW - curriculum framework Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66011 SN - 2194-1599 SN - 2194-1602 IS - 3 SP - 105 EP - 110 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Beck, Hanno T1 - Das literarische Testament Alexander von Humboldts 1799 JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies KW - Literarisches Testament KW - neu gelesen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70126 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 87 EP - 95 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Beck, Jan A1 - Holloway, Jeremy D. A1 - Schwanghart, Wolfgang T1 - Undersampling and the measurement of beta diversity JF - Methods in ecology and evolution : an official journal of the British Ecological Society N2 - Beta diversity is a conceptual link between diversity at local and regional scales. Various additional methodologies of quantifying this and related phenomena have been applied. Among them, measures of pairwise (dis)similarity of sites are particularly popular. Undersampling, i.e. not recording all taxa present at a site, is a common situation in ecological data. Bias in many metrics related to beta diversity must be expected, but only few studies have explicitly investigated the properties of various measures under undersampling conditions. On the basis of an empirical data set, representing near-complete local inventories of the Lepidoptera from an isolated Pacific island, as well as simulated communities with varying properties, we mimicked different levels of undersampling. We used 14 different approaches to quantify beta diversity, among them dataset-wide multiplicative partitioning (i.e. true beta diversity') and pairwise site x site dissimilarities. We compared their values from incomplete samples to true results from the full data. We used these comparisons to quantify undersampling bias and we calculated correlations of the dissimilarity measures of undersampled data with complete data of sites. Almost all tested metrics showed bias and low correlations under moderate to severe undersampling conditions (as well as deteriorating precision, i.e. large chance effects on results). Measures that used only species incidence were very sensitive to undersampling, while abundance-based metrics with high dependency on the distribution of the most common taxa were particularly robust. Simulated data showed sensitivity of results to the abundance distribution, confirming that data sets of high evenness and/or the application of metrics that are strongly affected by rare species are particularly sensitive to undersampling. The class of beta measure to be used should depend on the research question being asked as different metrics can lead to quite different conclusions even without undersampling effects. For each class of metric, there is a trade-off between robustness to undersampling and sensitivity to rare species. In consequence, using incidence-based metrics carries a particular risk of false conclusions when undersampled data are involved. Developing bias corrections for such metrics would be desirable. KW - Bray-Curtis KW - Chao KW - Effective number of species KW - Incomplete inventories KW - Jaccard KW - Macrolepidoptera KW - Morisita KW - Morisita-Horn KW - NESS KW - Norfolk Island Y1 - 2013 U6 - https://doi.org/10.1111/2041-210x.12023 SN - 2041-210X VL - 4 IS - 4 SP - 370 EP - 382 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Bellettini, Carlo A1 - Lonati, Violetta A1 - Malchiodi, Dario A1 - Monga, Mattia A1 - Morpurgo, Anna A1 - Torelli, Mauro T1 - What you see is what you have in mind BT - constructing mental models for formatted text processing JF - Commentarii informaticae didacticae : (CID) N2 - In this paper we report on our experiments in teaching computer science concepts with a mix of tangible and abstract object manipulations. The goal we set ourselves was to let pupils discover the challenges one has to meet to automatically manipulate formatted text. We worked with a group of 25 secondary school pupils (9-10th grade), and they were actually able to “invent” the concept of mark-up language. From this experiment we distilled a set of activities which will be replicated in other classes (6th grade) under the guidance of maths teachers. Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-64612 SN - 1868-0844 SN - 2191-1940 IS - 6 SP - 139 EP - 147 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ben-Abdallah, Philippe A1 - Messina, Riccardo A1 - Biehs, Svend-Age A1 - Tschikin, Maria A1 - Joulain, Karl A1 - Henkel, Carsten T1 - Heat superdiffusion in plasmonic nanostructure networks JF - Physical review letters N2 - The heat transport mediated by near-field interactions in networks of plasmonic nanostructures is shown to be analogous to a generalized random walk process. The existence of superdiffusive regimes is demonstrated both in linear ordered chains and in three-dimensional random networks by analyzing the asymptotic behavior of the corresponding probability distribution function. We show that the spread of heat in these networks is described by a type of Levy flight. The presence of such anomalous heat-transport regimes in plasmonic networks opens the way to the design of a new generation of composite materials able to transport heat faster than the normal diffusion process in solids. Y1 - 2013 U6 - https://doi.org/10.1103/PhysRevLett.111.174301 SN - 0031-9007 SN - 1079-7114 VL - 111 IS - 17 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Benacka, Jan T1 - BubbleSort, SelectSort and InsertSort in Excel & Delphi BT - learning the Concepts in a Constructionist Way JF - Commentarii informaticae didacticae : (CID) N2 - A method is presented of acquiring the principles of three sorting algorithms through developing interactive applications in Excel. KW - spreadsheets KW - sorting KW - constructionism Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-64636 SN - 1868-0844 SN - 2191-1940 IS - 6 SP - 153 EP - 154 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Benina, Maria A1 - Obata, Toshihiro A1 - Mehterov, Nikolay A1 - Ivanov, Ivan A1 - Petrov, Veselin A1 - Toneva, Valentina A1 - Fernie, Alisdair R. A1 - Gechev, Tsanko S. T1 - Comparative metabolic profiling of Haberlea rhodopensis, Thellungiella halophyla, and Arabidopsis thaliana exposed to low temperature JF - Frontiers in plant science N2 - Haberlea rhodopensis is a resurrection species with extreme resistance to drought stress and desiccation but also with ability to withstand low temperatures and freezing stress. In order to identify biochemical strategies which contribute to Haberlea's remarkable stress tolerance, the metabolic reconfiguration of H. rhodopensis during low temperature (4 degrees C) and subsequent return to optimal temperatures (21 degrees C) was investigated and compared with that of the stress tolerant Thellungiella halophyla and the stress sensitive Arabidopsis thaliana. Metabolic analysis by GC-MS revealed intrinsic differences in the metabolite levels of the three species even at 21 degrees C. H. rhodopensis had significantly more raffinose, melibiose, trehalose, rhamnose, myo-inositol, sorbitol, galactinol, erythronate, threonate, 2-oxoglutarate, citrate, and glycerol than the other two species. A. thaliana had the highest levels of putrescine and fumarate, while T halophila had much higher levels of several amino acids, including alanine, asparagine, beta-alanine, histidine, isoleucine, phenylalanine, serine, threonine, and valine. In addition, the three species responded differently to the low temperature treatment and the subsequent recovery, especially with regard to the sugar metabolism. Chilling induced accumulation of maltose in H. rhodopensis and raffinose in A. thaliana but the raffinose levels in low temperature exposed Arabidopsis were still much lower than these in unstressed Haberlea. While all species accumulated sucrose during chilling, that accumulation was transient in H. rhodopensis and A. thaliana but sustained in T halophila after the return to optimal temperature. Thus, Haberlea's metabolome appeared primed for chilling stress but the low temperature acclimation induced additional stress-protective mechanisms. A diverse array of sugars, organic acids, and polyols constitute Haberlea's main metabolic defence mechanisms against chilling, while accumulation of amino acids and amino acid derivatives contribute to the low temperature acclimation in Arabidopsis and Thellungiella. Collectively, these results show inherent differences in the metabolomes under the ambient temperature and the strategies to respond to low temperature in the three species. KW - Arabidopsis thaliana KW - Haberlea rhodopensis KW - low temperature stress KW - metabolite profiling KW - Thellungiella halophila Y1 - 2013 U6 - https://doi.org/10.3389/fpls.2013.00499 SN - 1664-462X VL - 4 IS - 1 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Bentele, Kajetan A1 - Saffert, Paul A1 - Rauscher, Robert A1 - Ignatova, Zoya A1 - Bluethgen, Nils T1 - Efficient translation initiation dictates codon usage at gene start JF - Molecular systems biology N2 - The genetic code is degenerate; thus, protein evolution does not uniquely determine the coding sequence. One of the puzzles in evolutionary genetics is therefore to uncover evolutionary driving forces that result in specific codon choice. In many bacteria, the first 5-10 codons of protein-coding genes are often codons that are less frequently used in the rest of the genome, an effect that has been argued to arise from selection for slowed early elongation to reduce ribosome traffic jams. However, genome analysis across many species has demonstrated that the region shows reduced mRNA folding consistent with pressure for efficient translation initiation. This raises the possibility that unusual codon usage is a side effect of selection for reduced mRNA structure. Here we discriminate between these two competing hypotheses, and show that in bacteria selection favours codons that reduce mRNA folding around the translation start, regardless of whether these codons are frequent or rare. Experiments confirm that primarily mRNA structure, and not codon usage, at the beginning of genes determines the translation rate. KW - codon usage KW - mRNA structure KW - translation Y1 - 2013 U6 - https://doi.org/10.1038/msb.2013.32 SN - 1744-4292 VL - 9 IS - 6 PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Berenstein, Igal A1 - Beta, Carsten T1 - Cross-diffusion in the two-variable Oregonator model JF - Chaos : an interdisciplinary journal of nonlinear science N2 - We explore the effect of cross-diffusion on pattern formation in the two-variable Oregonator model of the Belousov-Zhabotinsky reaction. For high negative cross-diffusion of the activator (the activator being attracted towards regions of increased inhibitor concentration) we find, depending on the values of the parameters, Turing patterns, standing waves, oscillatory Turing patterns, and quasi-standing waves. For the inhibitor, we find that positive cross-diffusion (the inhibitor being repelled by increasing concentrations of the activator) can induce Turing patterns, jumping waves and spatially modulated bulk oscillations. We qualitatively explain the formation of these patterns. With one model we can explain Turing patterns, standing waves and jumping waves, which previously was done with three different models. Y1 - 2013 U6 - https://doi.org/10.1063/1.4816937 SN - 1054-1500 VL - 23 IS - 3 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Berger, Anja A1 - Krahé, Barbara T1 - Negative attributes are gendered too - conceptualizing and measuring positive and negative facets of sex-role identity JF - European journal of social psychology N2 - Measures of gender identity have almost exclusively relied on positive aspects of masculinity and femininity, although conceptually the self-concept is not limited to positive attributes. A theoretical argument is made for considering negative attributes of gender identity, followed by five studies developing the Positive-Negative Sex-Role Inventory (PN-SRI) as a new measure of gender identity. Study 1 demonstrated that many of the attributes of a German version of the Bem Sex-Role Inventory are no longer considered to differ in desirability for men and women. For the PN-SRI, Study 2 elicited attributes characterizing men and women in today's society, for which ratings of typicality and desirability as well as self-ratings by men and women were obtained in Study 3. Study 4 examined the reliability and factorial structure of the four subscales of positive and negative masculinity and femininity and demonstrated the construct and discriminant validity of the PN-SRI by showing that the negative masculinity and femininity scales were unique predictors of select validation constructs. Study 5 showed that the new instrument explained variance in the validation constructs beyond earlier measures of gender identity. Key message: Even in the construction of negative aspects of gender identity, individuals prefer gender-congruent attributes. Negative masculinity and femininity make a unique contribution to understanding gender-related differences in psychological outcome variables. Y1 - 2013 U6 - https://doi.org/10.1002/ejsp.1970 SN - 0046-2772 VL - 43 IS - 6 SP - 516 EP - 531 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Berges, Marc A1 - Mühling, Andreas A1 - Hubwieser, Peter A1 - Steuer, Horst T1 - Informatik für Nichtinformatiker BT - ein kontext- und praxisorientiertes Konzept JF - Commentarii informaticae didacticae : (CID) N2 - Wir stellen die Konzeption und erste Ergebnisse einer neuartigen Informatik- Lehrveranstaltung für Studierende der Geodäsie vor. Das Konzept verbindet drei didaktische Ideen: Kontextorientierung, Peer-Tutoring und Praxisbezug (Course). Die Studierenden sollen dabei in zwei Semestern wichtige Grundlagen der Informatik verstehen und anzuwenden lernen. Durch enge Verzahnung der Aufgaben mit einem für Nichtinformatiker relevanten Kontext, sowie einem sehr hohen Anteil von Selbsttätigkeit der Studierenden soll die Motivation für fachfremde Themen gesteigert werden. Die Ergebnisse zeigen, dass die Veranstaltung sehr erfolgreich war. Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-64962 SN - 1868-0844 SN - 2191-1940 IS - 5 SP - 105 EP - 110 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Berry, Carol A1 - Kusterer, Peter T1 - Using Teachers’ TryScience to support educators and improve teaching JF - Commentarii informaticae didacticae : (CID) N2 - The challenge is providing teachers with the resources they need to strengthen their instructions and better prepare students for the jobs of the 21st Century. Technology can help meet the challenge. Teachers’ Tryscience is a noncommercial offer, developed by the New York Hall of Science, TeachEngineering, the National Board for Professional Teaching Standards and IBM Citizenship to provide teachers with such resources. The workshop provides deeper insight into this tool and discussion of how to support teaching of informatics in schools. KW - science KW - teacher KW - collaboration KW - teaching material KW - instruction KW - lesson KW - social networking Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-64665 SN - 1868-0844 SN - 2191-1940 IS - 6 SP - 161 EP - 162 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Bertz, Andreas A1 - Wöhl-Bruhn, Stefanie A1 - Miethe, Sebastian A1 - Tiersch, Brigitte A1 - Koetz, Joachim A1 - Hust, Michael A1 - Bunjes, Heike A1 - Menzel, Henning T1 - Encapsulation of proteins in hydrogel carrier systems for controlled drug delivery influence of network structure and drug size on release rate JF - Journal of biotechnology N2 - Novel hydrogels based on hydroxyethyl starch modified with polyethylene glycol methacrylate (HES-P(EG)(6)MA) were developed as delivery system for the controlled release of proteins. Since the drug release behavior is supposed to be related to the pore structure of the hydrogel network the pore sizes were determined by cryo-SEM, which is a mild technique for imaging on a nanometer scale. The results showed a decreasing pore size and an increase in pore homogeneity with increasing polymer concentration. Furthermore, the mesh sizes of the hydrogels were calculated based on swelling data. Pore and mesh size were significantly different which indicates that both structures are present in the hydrogel. The resulting structural model was correlated with release data for bulk hydrogel cylinders loaded with FITC-dextran and hydrogel microspheres loaded with FITC-IgG and FITC-dextran of different molecular size. The initial release depended much on the relation between hydrodynamic diameter and pore size while the long term release of the incorporated substances was predominantly controlled by degradation of the network of the much smaller meshes. KW - Hydrogel KW - Hydrogel microspheres KW - Network structure KW - Release studies KW - Protein delivery KW - Mesh size Y1 - 2013 U6 - https://doi.org/10.1016/j.jbiotec.2012.06.036 SN - 0168-1656 VL - 163 IS - 2 SP - 243 EP - 249 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bescherer, Klaus A1 - Munzke, Dorit A1 - Reich, Oliver A1 - Loock, Hans-Peter T1 - Fabrication and modeling of multimode fiber lenses JF - Applied optics N2 - We report on the fabrication, modeling, and experimental verification of the emission of fiber lenses fabricated on multimode fibers in different media. Concave fiber lenses with a radius of 150 mu m were fabricated onto a multimode silica fiber (100 mu m core) by grinding and polishing against a ruby sphere template. In our theoretical model we assume that the fiber guides light from a Lambertian light source and that the emission cone is governed solely by the range of permitted emission angles. We investigate concave and convex lenses at 532 nm with different radii and in a variety of surrounding media from air (n(0) = 1.00) to sapphire (n(0) = 1.77). It was found that noticeable focusing or defocusing effects of a silica fiber lens in ethanol (n(0) = 1.36) and dimethyl sulfoxide (DMSO) (n(0) = 1.48) are only observed when the fiber lens radius was less than the fiber diameter. Y1 - 2013 U6 - https://doi.org/10.1364/AO.52.000B40 SN - 1559-128X SN - 2155-3165 VL - 52 IS - 4 SP - B40 EP - B45 PB - Optical Society of America CY - Washington ER - TY - JOUR A1 - Beuster, Liane A1 - Elkina, Margarita A1 - Fortenbacher, Albrecht A1 - Kappe, Leonard A1 - Merceron, Agathe A1 - Pursian, Andreas A1 - Schwarzrock, Sebastian A1 - Wenzlaff, Boris T1 - Prototyp einer plattformunabhängigen Learning Analytics Applikation – fokussiert auf Nutzungsanalyse und Pfadanalyse JF - E-Learning Symposium 2012 : Aktuelle Anwendungen, innovative Prozesse und neueste Ergebnisse aus der E-Learning-Praxis ; Potsdam, 17. November 2012 N2 - Bei der hier vorgestellten Anwendung handelt es sich um den Prototypen einer webbasierten Applikation zur Analyse von Nutzungsdaten der AnwenderInnen von eLearning-Angeboten. Die Applikation wurde dabei explizit für unterschiedliche Zielgruppen wie eLearning-AnbieterInnen, Lehrende und WissenschaftlerInnen entworfen. Die Anwendung kann Daten verschiedener Lernplattformen auswerten und nutzt hierbei Methoden des Educational Data Mining. Sie unterstützt dabei sowohl klassische Plattformen mit personalisiertem Zugang sowie offene Plattformen, deren Angebote ohne Registrierung zugänglich sind. Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442166 SP - 69 EP - 72 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Beye, Martin A1 - Anniyev, Toyli A1 - Coffee, Ryan A1 - Dell'Angela, Martina A1 - Föhlisch, Alexander A1 - Gladh, J. A1 - Katayama, T. A1 - Kaya, S. A1 - Krupin, O. A1 - Mogelhoj, A. A1 - Nilsson, A. A1 - Nordlund, D. A1 - Norskov, J. K. A1 - Oberg, H. A1 - Ogasawara, H. A1 - Pettersson, Lars G. M. A1 - Schlotter, W. F. A1 - Sellberg, J. A. A1 - Sorgenfrei, Nomi A1 - Turner, J. J. A1 - Wolf, M. A1 - Wurth, Wilfried A1 - Ostrom, H. T1 - Selective ultrafast probing of transient hot chemisorbed and precursor States of CO on Ru(0001) JF - Physical review letters N2 - We have studied the femtosecond dynamics following optical laser excitation of CO adsorbed on a Ru surface by monitoring changes in the occupied and unoccupied electronic structure using ultrafast soft x-ray absorption and emission. We recently reported [M. Dell'Angela et al. Science 339, 1302 (2013)] a phonon-mediated transition into a weakly adsorbed precursor state occurring on a time scale of >2 ps prior to desorption. Here we focus on processes within the first picosecond after laser excitation and show that the metal-adsorbate coordination is initially increased due to hot-electron-driven vibrational excitations. This process is faster than, but occurs in parallel with, the transition into the precursor state. With resonant x-ray emission spectroscopy, we probe each of these states selectively and determine the respective transient populations depending on optical laser fluence. Ab initio molecular dynamics simulations of CO adsorbed on Ru(0001) were performed at 1500 and 3000 K providing insight into the desorption process. Y1 - 2013 U6 - https://doi.org/10.1103/PhysRevLett.110.186101 SN - 0031-9007 VL - 110 IS - 18 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Beye, Martin A1 - Föhlisch, Alexander T1 - Soft X-ray probes of ultrafast dynamics for heterogeneous catalysis JF - Chemical physics : a journal devoted to experimental and theoretical research involving problems of both a chemical and physical nature N2 - Soft X-ray spectroscopy is one of the best tools to directly address the electronic structure, the driving force of chemical reactions. It enables selective studies on sample surfaces to single out reaction centers in heterogeneous catalytic reactions. With core-hole clock methods, specific dynamics are related to the femtosecond life time of a core-hole. Typically, this method is used with photoemission spectroscopy, but advancements in soft X-ray emission techniques render more specific studies possible. With the advent of bright femtosecond pulsed soft X-ray sources, highly selective pump-probe X-ray emission studies are enabled with temporal resolutions down to tens of femtoseconds. This finally allows to study dynamics in the electronic structure of adsorbed reaction centers on the whole range of relevant time scales - closing the gap between kinetic soft X-ray studies and the atto- to femtosecond core-hole clock techniques. KW - Core-hole clock KW - Resonant inelastic X-ray scattering KW - Ultrafast surface science KW - Photoelectron spectroscopy Y1 - 2013 U6 - https://doi.org/10.1016/j.chemphys.2012.03.023 SN - 0301-0104 SN - 1873-4421 VL - 414 IS - 5 SP - 130 EP - 138 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Beye, Martin A1 - Schreck, S. A1 - Sorgenfrei, Nomi A1 - Trabant, C. A1 - Pontius, N. A1 - Schüßler-Langeheine, C. A1 - Wurth, W. A1 - Föhlisch, Alexander T1 - Stimulated X-ray emission for materials science JF - Nature : the international weekly journal of science N2 - Resonant inelastic X-ray scattering and X-ray emission spectroscopy can be used to probe the energy and dispersion of the elementary low-energy excitations that govern functionality in matter: vibronic, charge, spin and orbital excitations(1-7). A key drawback of resonant inelastic X-ray scattering has been the need for high photon densities to compensate for fluorescence yields of less than a per cent for soft X-rays(8). Sample damage from the dominant non-radiative decays thus limits the materials to which such techniques can be applied and the spectral resolution that can be obtained. A means of improving the yield is therefore highly desirable. Here we demonstrate stimulated X-ray emission for crystalline silicon at photon densities that are easily achievable with free-electron lasers(9). The stimulated radiative decay of core excited species at the expense of non-radiative processes reduces sample damage and permits narrow-bandwidth detection in the directed beam of stimulated radiation. We deduce how stimulated X-ray emission can be enhanced by several orders of magnitude to provide, with high yield and reduced sample damage, a superior probe for low-energy excitations and their dispersion in matter. This is the first step to bringing nonlinear X-ray physics in the condensed phase from theory(10-16) to application. Y1 - 2013 U6 - https://doi.org/10.1038/nature12449 SN - 0028-0836 VL - 501 IS - 7466 SP - 191 EP - + PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Beye, Martin A1 - Wernet, Ph. A1 - Schüßler-Langeheine, Christian A1 - Föhlisch, Alexander T1 - Time resolved resonant inelastic X-ray scattering: a supreme tool to understand dynamics in solids and molecules JF - Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy N2 - Dynamics in materials typically involve different degrees of freedom, like charge, lattice, orbital and spin in a complex interplay. Time-resolved resonant inelastic X-ray scattering (RIXS) as a highly selective tool can provide unique insight and follow the details of dynamical processes while resolving symmetries, chemical and charge states, momenta, spin configurations, etc. In this paper, we review examples where the intrinsic scattering duration time is used to study femtosecond phenomena. Free-electron lasers access timescales starting in the sub-ps range through pump-probe methods and synchrotrons study the time scales longer than tens of ps. In these examples, time-resolved resonant inelastic X-ray scattering is applied to solids as well as molecular systems. KW - Resonant inelastic X-ray scattering KW - Ultrafast spectroscopy KW - Phase transitions KW - Molecular dynamics Y1 - 2013 U6 - https://doi.org/10.1016/j.elspec.2013.04.013 SN - 0368-2048 VL - 188 IS - 3 SP - 172 EP - 182 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Beyene, Yonas A1 - Katoh, Shigehiro A1 - Wolde Gabriel, Giday A1 - Hart, William K. A1 - Uto, Kozo A1 - Sudo, Masafumi A1 - Kondo, Megumi A1 - Hyodo, Masayuki A1 - Renne, Paul R. A1 - Suwa, Gen A1 - Asfaw, Berhane T1 - The characteristics and chronology of the earliest. Acheulean at Konso, Ethiopia JF - Proceedings of the National Academy of Sciences of the United States of America N2 - The Acheulean technological tradition, characterized by a large (>10 cm) flake-based component, represents a significant technological advance over the Oldowan. Although stone tool assemblages attributed to the Acheulean have been reported from as early as circa 1.6-1.75 Ma, the characteristics of these earliest occurrences and comparisons with later assemblages have not been reported in detail. Here, we provide a newly established chronometric calibration for the Acheulean assemblages of the Konso Formation, southern Ethiopia, which span the time period similar to 1.75 to <1.0 Ma. The earliest Konso Acheulean is chronologically indistinguishable from the assemblage recently published as the world's earliest with an age of similar to 1.75 Ma at Kokiselei, west of Lake Turkana, Kenya. This Konso assemblage is characterized by a combination of large picks and crude bifaces/unifaces made predominantly on large flake blanks. An increase in the number of flake scars was observed within the Konso Formation handaxe assemblages through time, but this was less so with picks. The Konso evidence suggests that both picks and handaxes were essential components of the Acheulean from its initial stages and that the two probably differed in function. The temporal refinement seen, especially in the handaxe forms at Konso, implies enhanced function through time, perhaps in processing carcasses with long and stable cutting edges. The documentation of the earliest Acheulean at similar to 1.75 Ma in both northern Kenya and southern Ethiopia suggests that behavioral novelties were being established in a regional scale at that time, paralleling the emergence of Homo erectus-like hominid morphology. KW - chronostratigraphy KW - Early Pleistocene KW - lithic technology development Y1 - 2013 U6 - https://doi.org/10.1073/pnas.1221285110 SN - 0027-8424 VL - 110 IS - 5 SP - 1584 EP - 1591 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Bhabak, Krishna P. A1 - Kleuser, Burkhard A1 - Huwiler, Andrea A1 - Arenz, Christoph T1 - Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues JF - Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines N2 - Induction of apoptosis mediated by the inhibition of ceramidases has been shown to enhance the efficacy of conventional chemotherapy in several cancer models. Among the inhibitors of ceramidases reported in the literature, B-13 is considered as a lead compound having good in vitro potency towards acid ceramidase. Furthermore, owing to the poor activity of B-13 on lysosoamal acid ceramidase in living cells, LCL-464 a modified derivative of B-13 containing a basic omega-amino group at the fatty acid was reported to have higher potency towards lysosomal acid ceramidase in living cells. In a search for more potent inhibitors of ceramidases, we have designed a series of compounds with structural modifications of B-13 and LCL-464. In this study, we show that the efficacy of B-13 in vitro as well as in intact cells can be enhanced by suitable modification of functional groups. Furthermore, a detailed SAR investigation on LCL-464 analogues revealed novel promising inhibitors of aCDase and nCDase. In cell culture studies using the breast cancer cell line MDA-MB-231, some of the newly developed compounds elevated endogenous ceramide levels and in parallel, also induced apoptotic cell death. In summary, this study shows that structural modification of the known ceramidase inhibitors B-13 and LCL-464 generates more potent ceramidase inhibitors that are active in intact cells and not only elevates the cellular ceramide levels, but also enhances cell death. KW - Sphingolipids KW - Ceramide KW - Ceramidase inhibitors KW - Structure-activity-relationship Y1 - 2013 U6 - https://doi.org/10.1016/j.bmc.2012.12.014 SN - 0968-0896 VL - 21 IS - 4 SP - 874 EP - 882 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Bhatara, Anjali A1 - Boll-Avetisyan, Natalie A1 - Unger, Annika A1 - Nazzi, Thierry A1 - Höhle, Barbara T1 - Native language affects rhythmic grouping of speech JF - The journal of the Acoustical Society of America N2 - Perceptual attunement to one's native language results in language-specific processing of speech sounds. This includes stress cues, instantiated by differences in intensity, pitch, and duration. The present study investigates the effects of linguistic experience on the perception of these cues by studying the Iambic-Trochaic Law (ITL), which states that listeners group sounds trochaically (strong-weak) if the sounds vary in loudness or pitch and iambically (weak-strong) if they vary in duration. Participants were native listeners either of French or German; this comparison was chosen because French adults have been shown to be less sensitive than speakers of German and other languages to word-level stress, which is communicated by variation in cues such as intensity, fundamental frequency (F0), or duration. In experiment 1, participants listened to sequences of co-articulated syllables varying in either intensity or duration. The German participants were more consistent in their grouping than the French for both cues. Experiment 2 was identical to experiment 1 except that intensity variation was replaced by pitch variation. German participants again showed more consistency for both cues, and French participants showed especially inconsistent grouping for the pitch-varied sequences. These experiments show that the perception of linguistic rhythm is strongly influenced by linguistic experience. Y1 - 2013 U6 - https://doi.org/10.1121/1.4823848 SN - 0001-4966 SN - 1520-8524 VL - 134 IS - 5 SP - 3828 EP - 3843 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Bindschadler, Robert A. A1 - Nowicki, Sophie A1 - Abe-Ouchi, Ayako A1 - Aschwanden, Andy A1 - Choi, Hyeungu A1 - Fastook, Jim A1 - Granzow, Glen A1 - Greve, Ralf A1 - Gutowski, Gail A1 - Herzfeld, Ute A1 - Jackson, Charles A1 - Johnson, Jesse A1 - Khroulev, Constantine A1 - Levermann, Anders A1 - Lipscomb, William H. A1 - Martin, Maria A. A1 - Morlighem, Mathieu A1 - Parizek, Byron R. A1 - Pollard, David A1 - Price, Stephen F. A1 - Ren, Diandong A1 - Saito, Fuyuki A1 - Sato, Tatsuru A1 - Seddik, Hakime A1 - Seroussi, Helene A1 - Takahashi, Kunio A1 - Walker, Ryan A1 - Wang, Wei Li T1 - Ice-sheet model sensitivities to environmental forcing and their use in projecting future sea level (the SeaRISE project) JF - Journal of glaciology N2 - Ten ice-sheet models are used to study sensitivity of the Greenland and Antarctic ice sheets to prescribed changes of surface mass balance, sub-ice-shelf melting and basal sliding. Results exhibit a large range in projected contributions to sea-level change. In most cases, the ice volume above flotation lost is linearly dependent on the strength of the forcing. Combinations of forcings can be closely approximated by linearly summing the contributions from single forcing experiments, suggesting that nonlinear feedbacks are modest. Our models indicate that Greenland is more sensitive than Antarctica to likely atmospheric changes in temperature and precipitation, while Antarctica is more sensitive to increased ice-shelf basal melting. An experiment approximating the Intergovernmental Panel on Climate Change's RCP8.5 scenario produces additional first-century contributions to sea level of 22.3 and 8.1 cm from Greenland and Antarctica, respectively, with a range among models of 62 and 14 cm, respectively. By 200 years, projections increase to 53.2 and 26.7 cm, respectively, with ranges of 79 and 43 cm. Linear interpolation of the sensitivity results closely approximates these projections, revealing the relative contributions of the individual forcings on the combined volume change and suggesting that total ice-sheet response to complicated forcings over 200 years can be linearized. Y1 - 2013 U6 - https://doi.org/10.3189/2013JoG12J125 SN - 0022-1430 VL - 59 IS - 214 SP - 195 EP - 224 PB - International Glaciological Society CY - Cambridge ER - TY - JOUR A1 - Birke, Rainer T1 - Internationale Abkommen zur Korruptionsbekämpfung, Bestechungsvorschriften des deutschen sowie des russischen Strafrechts und die Gastfreundschaft JF - Schriften zum deutschen und russischen Strafrecht Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-67571 SN - 2191-0898 IS - 3 SP - 75 EP - 82 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Lascorz, Jesus A1 - Zimmermann, Ulrich S. A1 - Esser, Günter A1 - Desrivieres, Sylvane A1 - Schmidt, Martin H. A1 - Banaschewski, Tobias A1 - Schumann, Gunter A1 - Laucht, Manfred T1 - Association of PER2 genotype and stressful life events with alcohol drinking in young adults JF - PLoS one N2 - Background: Clock genes govern circadian rhythms and shape the effect of alcohol use on the physiological system. Exposure to severe negative life events is related to both heavy drinking and disturbed circadian rhythmicity. The aim of this study was 1) to extend previous findings suggesting an association of a haplotype tagging single nucleotide polymorphism of PER2 gene with drinking patterns, and 2) to examine a possible role for an interaction of this gene with life stress in hazardous drinking. Methods: Data were collected as part of an epidemiological cohort study on the outcome of early risk factors followed since birth. At age 19 years, 268 young adults (126 males, 142 females) were genotyped for PER2 rs56013859 and were administered a 45-day alcohol timeline follow-back interview and the Alcohol Use Disorders Identification Test (AUDIT). Life stress was assessed as the number of severe negative life events during the past four years reported in a questionnaire and validated by interview. Results: Individuals with the minor G allele of rs56013859 were found to be less engaged in alcohol use, drinking at only 72% of the days compared to homozygotes for the major A allele. Moreover, among regular drinkers, a gene x environment interaction emerged (p = .020). While no effects of genotype appeared under conditions of low stress, carriers of the G allele exhibited less hazardous drinking than those homozygous for the A allele when exposed to high stress. Conclusions: These findings may suggest a role of the circadian rhythm gene PER2 in both the drinking patterns of young adults and in moderating the impact of severe life stress on hazardous drinking in experienced alcohol users. However, in light of the likely burden of multiple tests, the nature of the measures used and the nominal evidence of interaction, replication is needed before drawing firm conclusions. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0059136 SN - 1932-6203 VL - 8 IS - 3 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Blomeyer, Dorothea A1 - Friemel, Chris M. A1 - Buchmann, Arlette F. A1 - Banaschewski, Tobias A1 - Laucht, Manfred A1 - Schneider, Miriam T1 - Impact of pubertal stage at first drink on adult drinking behavior JF - Alcoholism : clinical and experimental research ; the official journal of the American Medical Society on Alcoholism and the Research Society on Alcoholism N2 - BackgroundEarly alcohol use is one of the strongest predictors of later alcohol use disorders, with early use usually taking place during puberty. Many researchers have suggested drinking during puberty as a potential biological basis of the age at first drink (AFD) effect. However, the influence of the pubertal phase at alcohol use initiation on subsequent drinking in later life has not been examined so far. MethodsPubertal stage at first drink (PSFD) was determined in N=283 young adults (131 males, 152 females) from an epidemiological cohort study. At ages 19, 22, and 23years, drinking behavior (number of drinking days, amount of alcohol consumed, hazardous drinking) was assessed using interview and questionnaire methods. Additionally, an animal study examined the effects of pubertal or adult ethanol (EtOH) exposure on voluntary EtOH consumption in later life in 20 male Wistar rats. ResultsPSFD predicted drinking behavior in humans in early adulthood, indicating that individuals who had their first drink during puberty displayed elevated drinking levels compared to those with postpubertal drinking onset. These findings were corroborated by the animal study, in which rats that received free access to alcohol during the pubertal period were found to consume more alcohol as adults, compared to the control animals that first came into contact with alcohol during adulthood. ConclusionsThe results point to a significant role of stage of pubertal development at first contact with alcohol for the development of later drinking habits. Possible biological mechanisms and implications for prevention are discussed. KW - Age at First Drink KW - Alcohol Use KW - Puberty KW - Young Adulthood KW - Prospective Longitudinal Study Y1 - 2013 U6 - https://doi.org/10.1111/acer.12154 SN - 0145-6008 VL - 37 IS - 10 SP - 1804 EP - 1811 PB - Wiley-Blackwell CY - Hoboken ER -