TY  - JOUR
A1  - Meiser, Susanne
A1  - Esser, Günter
T1  - Interpersonal Stress Generation-A Girl Problem?
BT  - The Role of Depressive Symptoms, Dysfunctional Attitudes, and Gender in Early Adolescent Stress Generation
JF  - Journal of early adolescence
N2  - To provide further insight into stress generation patterns in boys and girls around puberty, this study investigated longitudinal reciprocal relations between depressive symptoms, dysfunctional attitudes, and stress generation, the process by which individuals contribute to the occurrence of stress in interpersonal contexts (e.g., problematic social interactions) or in noninterpersonal contexts (e.g., achievement problems). A community sample of N = 924 German children and early adolescents (51.8% male) completed depressive symptoms and dysfunctional attitudes measures at T1 and again 20 months later (T2). Stressful life events were reported at T2. Dysfunctional attitudes were unrelated to stress generation. Interpersonal, but not noninterpersonal, dependent stress partially mediated the relationship between initial and later depressive symptoms, with girls being more likely to generate interpersonal stress in response to depressive symptoms. Findings underscore the role of interpersonal stress generation in the early development of depressive symptomatology, and in the gender difference in depression prevalence emerging around puberty.
KW  - stress generation
KW  - depression
KW  - dysfunctional attitudes
KW  - children and adolescents
KW  - gender differences
Y1  - 2017
U6  - https://doi.org/10.1177/0272431617725197
SN  - 0272-4316
SN  - 1552-5449
VL  - 39
IS  - 1
SP  - 41
EP  - 66
PB  - Sage Publ.
CY  - Thousand Oaks
ER  - 
TY  - JOUR
A1  - Daviter, Falk
T1  - Policy analysis in the face of complexity
BT  - What kind of knowledge to tackle wicked problems?
JF  - Public policy and administration
N2  - An ever-increasing number of policy problems have come to be interpreted as representing a particular type of intractable, ill-structured or wicked policy problem. Much of this debate is concerned with the challenges wicked problems pose for program management rather than policy analysis. This article, in contrast, argues that the key challenge in addressing this type of policy problems is in fact analytical. Wicked policy problems are difficult to identify and interpret. The knowledge base for analysing wicked policy problem is typically fragmented and contested. Available evidence is incomplete, inconclusive and incommensurable. In this situation, the evidentiary and the interpretative elements of policy analysis become increasingly indistinguishable and inseparably intertwined. The article reveals the problems this poses for policy analysis and explores the extent to which the consolidation, consensualization and contestation of evidence in policy analysis offer alternative procedural paths to resolve these problems.
KW  - Evidence-based policy making
KW  - expertise
KW  - knowledge
KW  - policy analysis
KW  - wicked problems
Y1  - 2017
U6  - https://doi.org/10.1177/0952076717733325
SN  - 0952-0767
SN  - 1749-4192
VL  - 34
IS  - 1
PB  - Sage Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Warschburger, Petra
T1  - Jugendliche und junge Erwachsene mit Adipositas
T1  - Adolescents and Young Adults
BT  - Wie sollte in ihren Augen „die perfekte Therapie“ aussehen?
BT  - What Would a "Perfect Therapy" Look Like?
JF  - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation
N2  - Hauptziel Adipositas ist eine der Hauptindikationen in der Kinder- und Jugend-Rehabilitation. Für ältere Jugendliche und junge Erwachsene fehlen altersspezifische Therapieangebote fast vollständig. Ziel war es die Wünsche bezüglich der Inhalte und Methoden einer „perfekten Therapie“ im Rahmen eines Rehabilitationsaufenthalts zu untersuchen.

Methode Im Rahmen der YOUTH-Studie wurden 147 adipöse Jugendliche und junge Erwachsene beiderlei Geschlechts (zwischen 15 und 21 Jahren) mithilfe eines standardisierten Fragebogens befragt.

Ergebnis Insgesamt zeigten sich relativ wenige alters- und geschlechtsspezifische Unterschiede. Interdisziplinär geleitete, koedukative Gruppen mit Elterneinbindung wurden gewünscht. Wichtige Themen waren gesunde Ernährung sowie psychosoziale Aspekte. Auch der Prävention von Rückfällen wurde eine hohe Relevanz zugeschrieben.

Schlussfolgerung Psychosoziale Aspekte und die Vorbereitung auf mögliche Rückfallsituationen sollten integraler Bestandteil der Therapie sein.
N2  - Principal objective Obesity is a major indication for pediatric and adolescent-rehabilitation. Age-specific therapies for „emerging adults“ are lacking. The aim was to examine the patients’ preferences with respect to the contents and methods of the „perfect therapy“ within an inpatient setting.

Method In the context of the YOUTH study 147 obese male and female adolescents (aged 15–21 years) filled in standardized questionnaires.

Results Overall little age- and gender-specific differences were observed. The participants expressed a preference for interdisciplinary coordinated and coeducational group approaches with involvement of the parents. Major topics were healthy nutrition and psychosocial aspects. Prevention of relapses is considered as important as well.

Conclusion Psychosocial aspects and preparing coping with risk situations should be an integral part of treatment programs.
KW  - obesity
KW  - adolescents
KW  - young adults
KW  - therapy
KW  - requirements
KW  - Jugendliche
KW  - junge Erwachsene
KW  - Therapie
KW  - Anforderungen
KW  - Adipositas
Y1  - 2017
U6  - https://doi.org/10.1055/s-0043-107930
SN  - 0034-3536
SN  - 1439-1309
VL  - 57
IS  - 5
SP  - 295
EP  - 302
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Weiß, Norman
T1  - Origin and Further Development
JF  - The Council of Europe
Y1  - 2017
SN  - 978-0-19-967252-3
SP  - 3
EP  - 22
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Schotter, Elizabeth Roye
A1  - Leinenger, Mallorie
A1  - von der Malsburg, Titus Raban
T1  - When your mind skips what your eyes fixate
BT  - how forced fixations lead to comprehension illusions in reading
JF  - Psychonomic bulletin & review : a journal of the Psychonomic Society
N2  - The phenomenon of forced fixations suggests that readers sometimes fixate a word (due to oculomotor constraints) even though they intended to skip it (due to parafoveal cognitive-linguistic processing). We investigate whether this leads readers to look directly at a word but not pay attention to it. We used a gaze-contingent boundary paradigm to dissociate parafoveal and foveal information (e.g., the word phone changed to scarf once the reader's eyes moved to it) and asked questions about the sentence to determine which one the reader encoded. When the word was skipped or fixated only briefly (i.e., up to 100 ms) readers were more likely to report reading the parafoveal than the fixated word, suggesting that there are cases in which readers look directly at a word but their minds ignore it, leading to the illusion of reading something they did not fixate.
KW  - Word recognition
KW  - Text comprehension
KW  - Eye movements and reading
Y1  - 2017
U6  - https://doi.org/10.3758/s13423-017-1356-y
SN  - 1069-9384
SN  - 1531-5320
VL  - 25
IS  - 5
SP  - 1884
EP  - 1890
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Fedchenko, Dmitry
A1  - Tarkhanov, Nikolai Nikolaevich
T1  - A Rado theorem for the porous medium equation
JF  - Boletin de la Sociedad Matemática Mexicana
N2  - We prove that if u is a locally Lipschitz continuous function on an open set chi subset of Rn + 1 satisfying the nonlinear heat equation partial derivative(t)u = Delta(vertical bar u vertical bar(p-1) u), p > 1, weakly away from the zero set u(-1) (0) in chi, then u is a weak solution to this equation in all of chi.
KW  - Quasilinear equations
KW  - Removable sets
KW  - Porous medium equation
Y1  - 2017
U6  - https://doi.org/10.1007/s40590-017-0169-3
SN  - 1405-213X
SN  - 2296-4495
VL  - 24
IS  - 2
SP  - 427
EP  - 437
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Haile, Mekbib Gebretsadik
A1  - Kalkuhl, Matthias
A1  - Algieri, Bernardina
A1  - Gebreselassie, Samuel
T1  - Price shock transmission
BT  - evidence from the wheat-bread market value chain in Ethiopia
JF  - Agricultural economics
N2  - This study assesses the degree of vertical price transmission along the wheat-bread value chain in Ethiopia. This is pursued by applying a vector error correction model and an impulse response analysis using monthly price data for the period 2000-2015. Our analysis considers transmission of price shocks across different market levels, including from the international and domestic wheat grain markets at the upstream to the domestic wheat bread market at the downstream of the value chain. The empirical findings indicate that significant cointegration exists across prices of the different market stages. There is a transmission from international prices to domestic prices at downstream markets, in particular to flour and bread prices. Prices at upstream markets are largely influenced by the domestic wholesale market. In general, the speed of adjustment is quite slow with a half-life of about one year for restoring the equilibrium price relationship. As price margins between the different market stages in the value chain have substantially decreased in the last 15 years, higher transmission, and thus exposure to international market shocks, can be expected in the future. The results also show that causal relationships exist between prices at different market stageswith the wholesale market identified as the key market level where prices and price expectations are formed.
KW  - Q02
KW  - Q11
KW  - Q13
KW  - L11
KW  - M31
KW  - Value chain
KW  - Price transmission
KW  - Impulse response
KW  - Wheat
KW  - Ethiopia
Y1  - 2017
U6  - https://doi.org/10.1111/agec.12373
SN  - 0169-5150
SN  - 1574-0862
VL  - 48
IS  - 6
SP  - 769
EP  - 780
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Guerrero-Ramirez, Nathaly Rokssana
A1  - Craven, Dylan
A1  - Reich, Peter B.
A1  - Ewel, John J.
A1  - Isbell, Forest
A1  - Koricheva, Julia
A1  - Parrotta, John A.
A1  - Auge, Harald
A1  - Erickson, Heather E.
A1  - Forrester, David I.
A1  - Hector, Andy
A1  - Joshi, Jasmin Radha
A1  - Montagnini, Florencia
A1  - Palmborg, Cecilia
A1  - Piotto, Daniel
A1  - Potvin, Catherine
A1  - Roscher, Christiane
A1  - van Ruijven, Jasper
A1  - Tilman, David
A1  - Wilsey, Brian
A1  - Eisenhauer, Nico
T1  - Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems
JF  - Nature ecology & evolution
N2  - The effects of biodiversity on ecosystem functioning generally increase over time, but the underlying processes remain unclear. Using 26 long-term grassland and forest experimental ecosystems, we demonstrate that biodiversity-ecosystem functioning relationships strengthen mainly by greater increases in functioning in high-diversity communities in grasslands and forests. In grasslands, biodiversity effects also strengthen due to decreases in functioning in low-diversity communities. Contrasting trends across grasslands are associated with differences in soil characteristics.
Y1  - 2017
U6  - https://doi.org/10.1038/s41559-017-0325-1
SN  - 2397-334X
VL  - 1
IS  - 11
SP  - 1639
EP  - 1642
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Rein, Patrick
A1  - Ramson, Stefan
A1  - Lincke, Jens
A1  - Felgentreff, Tim
A1  - Hirschfeld, Robert
T1  - Group-Based Behavior Adaptation Mechanisms in Object-Oriented Systems
JF  - IEEE software
N2  - Dynamic and distributed systems require behavior adaptations for groups of objects. Group-based behavior adaptation mechanisms scope adaptations to objects matching conditions beyond class membership. The specification of groups can be explicit or implicit.
KW  - group-based behavior adaptation
KW  - lively groups
KW  - ContextErlang
KW  - entity-component-system
KW  - predicated generic functions
KW  - active layers
KW  - reactive object queries
KW  - context groups
KW  - implied methods
KW  - object-oriented languages
KW  - software engineering
KW  - software development
KW  - contextual-variability modeling
Y1  - 2017
U6  - https://doi.org/10.1109/MS.2017.4121224
SN  - 0740-7459
SN  - 1937-4194
VL  - 34
IS  - 6
SP  - 78
EP  - 82
PB  - Inst. of Electr. and Electronics Engineers
CY  - Los Alamitos
ER  - 
TY  - JOUR
A1  - Fitzi, Gregor
A1  - Marcucci, Nicola
T1  - Durkheim in Germany
BT  - the performance of a classic
JF  - Journal of Classical Sociology
Y1  - 2017
U6  - https://doi.org/10.1177/1468795X17735991
SN  - 1468-795X
SN  - 1741-2897
VL  - 17
IS  - 4
SP  - 271
EP  - 275
PB  - Sage Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Fitzi, Gregor
T1  - Dialogue. Divergence. Veiled Reception. Criticism: Georg Simmel’s
relationship with Emile Durkheim
JF  - Journal of Classical Sociology
N2  - Simmel was the only German sociologist who directly cooperated with Durkheim. After an initial impression of convergence between the sociology of social facts and the sociology of social forms, a break between the two founders of sociology became inevitable. Yet, Durkheim and Simmel went on positioning themselves against one other in the years ahead. Durkheim’s allegation of ‘individual psychologism’ induced Simmel to a veiled reception of Durkheim’s methodological approach that permitted him to refine the sociological epistemology he eventually presented in the Soziologie published in 1908. On this basis, he was able to formulate a final criticism of the sociology of social facts as a social psychology.
KW  - Sociology of social facts
KW  - sociology of social forms
KW  - moral sociology
KW  - transnormative sociology
KW  - criticism of social psychology
Y1  - 2017
U6  - https://doi.org/10.1177/1468795X17735994
SN  - 1468-795X
SN  - 1741-2897
VL  - 17
SP  - 293
EP  - 308
PB  - Sage Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Groop, Per-Henrik
A1  - Cooper, Mark E.
A1  - Perkovic, Vlado
A1  - Hocher, Berthold
A1  - Kanasaki, Keizo
A1  - Haneda, Masakazu
A1  - Schernthaner, Guntram
A1  - Sharma, Kumar
A1  - Stanton, Robert C.
A1  - Toto, Robert
A1  - Cescutti, Jessica
A1  - Gordat, Maud
A1  - Meinicke, Thomas
A1  - Koitka-Weber, Audrey
A1  - Thiemann, Sandra
A1  - von Eynatten, Maximilian
T1  - Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction
BT  - the randomized MARLINA-T2D trial
JF  - Diabetes obesity & metabolism : a journal of pharmacology and therapeutics
N2  - Aims: The MARLINA-T2D study (ClinicalTrials. gov, NCT01792518) was designed to investigate the glycaemic and renal effects of linagliptin added to standard-of-care in individuals with type 2 diabetes and albuminuria. Methods: A total of 360 individuals with type 2 diabetes, HbA1c 6.5% to 10.0% (48-86 mmol/ mol), estimated glomerular filtration rate (eGFR) >= 30 mL/min/1.73 m(2) and urinary albumin-tocreatinine ratio (UACR) 30-3000 mg/g despite single agent renin-angiotensin-system blockade were randomized to double-blind linagliptin (n = 182) or placebo (n = 178) for 24 weeks. The primary and key secondary endpoints were change from baseline in HbA1c at week 24 and time-weighted average of percentage change from baseline in UACR over 24 weeks, respectively. Results: Baseline mean HbA1c and geometric mean (gMean) UACR were 7.8% +/- 0.9% (62.2 +/- 9.6 mmol/mol) and 126 mg/g, respectively; 73.7% and 20.3% of participants had microalbuminuria or macroalbuminuria, respectively. After 24 weeks, the placebo-adjusted mean change in HbA1c from baseline was -0.60% (-6.6 mmol/mol) (95% confidence interval [CI], -0.78 to -0.43 [-8.5 to -4.7 mmol/mol]; P <.0001). The placebo-adjusted gMean for time-weighted average of percentage change in UACR from baseline was -6.0% (95% CI, -15.0 to 3.0; P =.1954). The adverse-event profile, including renal safety and change in eGFR, was similar between the linagliptin and placebo groups. Conclusions: In individuals at early stages of diabetic kidney disease, linagliptin significantly improved glycaemic control but did not significantly lower albuminuria. There was no significant change in placebo-adjusted eGFR. Detection of clinically relevant renal effects of linagliptin may require longer treatment, as its main experimental effects in animal studies have been to reduce interstitial fibrosis rather than alter glomerular haemodynamics.
KW  - antidiabetic drug
KW  - clinical trial
KW  - diabetic nephropathy
KW  - DPP-IV inhibitor
KW  - glycaemic control
KW  - linagliptin
Y1  - 2017
U6  - https://doi.org/10.1111/dom.13041
SN  - 1462-8902
SN  - 1463-1326
VL  - 19
IS  - 11
SP  - 1610
EP  - 1619
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Morandi, Bertrand
A1  - Kail, Jochem
A1  - Tödter, Anne
A1  - Wolter, Christian
A1  - Piegay, Herve
T1  - Diverse Approaches to Implement and Monitor River Restoration
BT  - a Comparative Perspective in France and Germany
JF  - Environmental Management
N2  - River restoration is a main emphasis of river management in European countries. Cross-national comparisons of its implementation are still rare in scientific literature. Based on French and German national censuses, this study compares river restoration practices and monitoring by analysing 102 French and 270 German projects. This comparison aims to draw a spatial and temporal framework of restoration practices in both countries to identify potential drivers of cross-national similarities and differences. The results underline four major trends: (1) a lag of almost 15 years in river restoration implementation between France and Germany, with a consequently higher share of projects in Germany than in France, (2) substantial similarities in restored reach characteristics, short reach length, small rivers, and in "agricultural" areas, (3) good correspondences between stressors identified and restoration measures implemented. Morphological alterations were the most important highlighted stressors. River morphology enhancement, especially instream enhancements, were the most frequently implemented restoration measures. Some differences exist in specific restoration practices, as river continuity restoration were most frequently implemented in French projects, while large wood introduction or channel re-braiding were most frequently implemented in German projects, and (4) some quantitative and qualitative differences in monitoring practices and a significant lack of project monitoring, especially in Germany compared to France. These similarities and differences between Germany and France in restoration application and monitoring possibly result from a complex set of drivers that might be difficult to untangle (e.g., environmental, technical, political, cultural).
KW  - River restoration
KW  - Project monitoring
KW  - Hydromorphologic alteration
KW  - Mitigation measures
KW  - France
KW  - Germany
Y1  - 2017
U6  - https://doi.org/10.1007/s00267-017-0923-3
SN  - 0364-152X
SN  - 1432-1009
VL  - 60
SP  - 931
EP  - 946
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Ferrer-Maestro, Juan José
A1  - Kunst, Christiane
A1  - Hernández de la Fuente, David
A1  - Faber, Eike
T1  - Prólogo
JF  - Entre los mundos: homenaje a Pedro Barceló  = Zwischen den Welten : Festschrift für Pedro Barceló
Y1  - 2017
SN  - 978-2-84867-578-7
SP  - 13
EP  - 17
PB  - Presses universitaires de Franche-Comté
CY  - Besançon
ER  - 
TY  - JOUR
A1  - Ferrer-Maestro, Juan José
A1  - Kunst, Christiane
A1  - Hernández de la Fuente, David
A1  - Faber, Eike
T1  - Vorwort
JF  - Entre los mundos: homenaje a Pedro Barceló = Zwischen den Welten : Festschrift für Pedro Barceló
Y1  - 2017
SN  - 978-2-84867-578-7
SP  - 19
EP  - 24
PB  - Presses universitaires de Franche-Comté
CY  - Besançon
ER  - 
TY  - JOUR
A1  - Faber, Eike
T1  - Augustus und die Provinzialen  im Reichsdienst
JF  - Entre los mundos : homenaje a Pedro Barceló = Zwischen den Welten : Festschrift für Pedro Barceló
Y1  - 2017
SN  - 978-2-84867-578-7
SP  - 101
EP  - 119
PB  - Presses universitaires de Franche-Comté
CY  - Besançon
ER  - 
TY  - JOUR
A1  - Miklashevsky, Alex A.
T1  - О высоком и низком: пространственная семантика абстрактных и конкретных существительных
JF  - Tomsk state university journal
N2  - Aim and material: In the present study, the data of the rating study presented earlier, where participants estimated the position of an object or phenomenon in vertical space by using the seven-point Likert scale, are used in order to systematically describe spatial information included in language units of different semantic categories. Background: The role of spatial semantics in language understanding is assumed by modern cognition theories and confirmed in experimental studies. Hypotheses: Based on conceptual metaphor theory, a number of hypotheses are proposed in the present study: different semantic categories of nouns (e.g., tools vs. animals vs. emotions etc.) should significantly differ in their spatial semantics as well; different semantic categories of abstract nouns (e.g., mental states vs. emotions vs. physical sensations) should also differ in their spatial semantics, as the latter is included in their conceptual structure; mental states and phenomena (e.g., imagination, thought or memory) should have higher values (i.e., be located higher in the virtual subjective space) than any other abstract concepts; emotional concepts (e.g., love, disgust or happiness) should be located higher than physical sensations (e.g., pain or softness); positive emotions (like joy or euphoria) should be located higher than negative ones (like feeling of guilt or disappointment). Methods: Statistical methods (parametric and non-parametric ones) are used in order to test the hypotheses. As additional cross-testing methods corpora data and expert assessment are included. Results: The results of the study confirmed all the hypotheses. A number of additional regularities were revealed: in general, abstract concepts get higher values on a scale, i.e., are located higher in the virtual subjective space than concrete ones; tool concepts are related more to the lower space, unlike sound concepts that are related to higher space. No difference was found between action concepts (like attack or running) and physical sensations. Discussion: The results obtained can also be explained in terms of other theories within the embodied cognition framework, as it is discussed in the conclusion (words as social tools by A. Borghi and F. Binkofski; ideas by G. Vigliocco and neurosemantic approach by F. Pulvermuller). The need in an integrative model and larger studies with other semantic categories is underlined.
N2  - Проведен анализ пространственной семантики различных категорий русских существительных, входящих в психолингви-стическую базуданных; особое внимание уделяется абстрактным концептам. Выявлены различия пространственной семантики наименований физических ощущений и действий, эмоций, ментальных процессов. Полученны ерезультаты обсуждаются с точки зрения отдельных подходов в рамках теории воплощенного познания – теории концептуальной метафоры, теории слов как социальных инструментов (WAT, Words As social Tools), нейросемантики.
T2  - About the high and the low: spatial semantics of abstract and concrete nouns
KW  - embodied cognition
KW  - spatial semantics
KW  - conceptual metaphor
KW  - neurosemantics
KW  - words as social tools
KW  - psycholinguistic databases
KW  - abstract concepts
KW  - абстрактные концепты
KW  - психолингвистическая база данных
KW  - слова как социальные инструменты
KW  - нейросемантика
KW  - концептуальная метафора
KW  - пространственная семантика
KW  - воплощенное познание
Y1  - 2017
U6  - https://doi.org/10.17223/15617793/424/4
SN  - 1561-7793
SN  - 1561-803X
IS  - 424
SP  - 26
EP  - 34
PB  - Tomsk Stata Univ
CY  - Tomsk
ER  - 
TY  - JOUR
A1  - Berry, Scott
A1  - Rosa, Stefanie
A1  - Howard, Martin
A1  - Buhler, Marc
A1  - Dean, Caroline
T1  - Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression
JF  - Genes & Development
N2  - Epigenetic maintenance of gene repression is essential for development. Polycomb complexes are central to this memory, but many aspects of the underlying mechanism remain unclear. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repression of many Polycomb target genes in Arabidopsis. Here we show that LHP1 binds RNA in vitro through the intrinsically disordered hinge region. By independently perturbing the RNA-binding hinge region and H3K27me3 (trimethylation of histone H3 at Lys27) recognition, we found that both facilitate LHP1 localization and H3K27me3 maintenance. Disruption of the RNAbinding hinge region also prevented formation of subnuclear foci, structures potentially important for epigenetic repression.
KW  - chromatin
KW  - epigenetics
KW  - plant biology
KW  - Polycomb
KW  - RNA
Y1  - 2017
U6  - https://doi.org/10.1101/gad.305227.117
SN  - 0890-9369
SN  - 1549-5477
VL  - 31
SP  - 2115
EP  - 2120
PB  - Cold Spring Harbor Laboratory Press
CY  - Cold Spring Harbor, NY
ER  - 
TY  - JOUR
A1  - Dimitrova, Ilinka
A1  - Koppitz, Jörg
T1  - On the semigroup of all partial fence-preserving injections on a finite set
JF  - Journal of Algebra and Its Applications
N2  - For n∈N , let Xn={a1,a2,…,an} be an n-element set and let F=(Xn;<f) be a fence, also called a zigzag poset. As usual, we denote by In the symmetric inverse semigroup on Xn. We say that a transformation α∈In is fence-preserving if x<fy implies that xα<fyα, for all x,y in the domain of α. In this paper, we study the semigroup PFIn of all partial fence-preserving injections of Xn and its subsemigroup IFn={α∈PFIn:α−1∈PFIn}. Clearly, IFn is an inverse semigroup and contains all regular elements of PFIn. We characterize the Green’s relations for the semigroup IFn. Further, we prove that the semigroup IFn is generated by its elements with rank ≥n−2. Moreover, for n∈2N, we find the least generating set and calculate the rank of IFn.
KW  - Finite transformation semigroup
KW  - fence-preserving transformations
KW  - inverse semigroup
KW  - Green´s Relations
KW  - generators
KW  - rank
Y1  - 2017
U6  - https://doi.org/10.1142/S0219498817502231
SN  - 0219-4988
SN  - 1793-6829
VL  - 16
IS  - 12
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Huck, Stefan
A1  - Wohlwend, Stephan
A1  - Coimbra, Rute
A1  - Christ, Nicolas
A1  - Weissert, Helmut
T1  - Disentangling shallow-water bulk carbonate carbon isotope archives with evidence for multi-stage diagenesis
BT  - an in-depth component-specific petrographic and geochemical study from Oman (mid-Cretaceous)
JF  - The depositional record
N2  - Disentangling shallow‐water bulk carbonate carbon isotope archives into primary and diagenetic components is a notoriously difficult task and even diagenetically screened records often provide chemostratigraphic patterns that significantly differ from global signals. This is mainly caused by the polygenetic nature of shallow‐water carbonate substrates, local carbon cycle processes causing considerable neritic–pelagic isotope gradients and the presence of hiatal surfaces resulting in extremely low carbonate preservation rates. Provided here is an in‐depth petrographic and geochemical evaluation of different carbonate phases of a mid‐Cretaceous (Barremian–Aptian) shallow‐water limestone succession (Jabal Madar section) deposited on the tropical Arabian carbonate platform in Oman. The superposition of stable isotope signatures of identified carbonate phases causes a complex and often noisy bulk carbon isotope pattern. Blocky sparite cements filling intergranular pores and bioclastic voids evidence intermediate to (arguably) deep burial diagenetic conditions during their formation, owing to different timing or differential faulting promoting the circulation of fluids from variable sources. In contrast, sparite cements filling sub‐vertical veins reveal a rock‐buffered diagenetic fluid composition with an intriguing moderate enrichment in 13C, probably due to fractionation during pressure release in the context of the Miocene exhumation of the carbonate platform under study. The presence of abundant, replacive dedolomite in mud‐supported limestone samples forced negative carbon and oxygen isotope changes that are either associated with the thermal breakdown of organic matter in the deep burial realm or the expulsion of buried meteoric water in the intermediate burial realm. Notwithstanding the documented stratigraphically variable and often facies‐related impact of different diagenetic fluids on the bulk‐rock stable isotope signature, the identification of diagenetic end‐members defined δ13C and δ18O threshold values that allowed the most reliable ‘primary’ bulk carbon isotope signatures to be extracted. Most importantly, this approach exemplifies how to place regional shallow‐water stable isotope patterns with evidence for a complex multi‐stage diagenetic history into a supraregional or even global context.
KW  - Arabian carbonate platform
KW  - Barremian-Aptian
KW  - multi-stage diagenesis
KW  - shallow-water chemostratigraphy
Y1  - 2017
U6  - https://doi.org/10.1002/dep2.35
SN  - 2055-4877
VL  - 3
SP  - 233
EP  - 257
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Stange, Maike
A1  - Hintsche, Marius
A1  - Sachse, Kirsten
A1  - Gerhardt, Matthias
A1  - Valleriani, Angelo
A1  - Beta, Carsten
T1  - Analyzing the spatial positioning of nuclei in polynuclear giant cells
JF  - Journal of Physics D: Applied Physics
N2  - How cells establish and maintain a well-defined size is a fundamental question of cell biology. Here we investigated to what extent the microtubule cytoskeleton can set a predefined cell size, independent of an enclosing cell membrane. We used electropulse-induced cell fusion to form giant multinuclear cells of the social amoeba Dictyostelium discoideum. Based on dual-color confocal imaging of cells that expressed fluorescent markers for the cell nucleus and the microtubules, we determined the subcellular distributions of nuclei and centrosomes in the giant cells. Our two- and three-dimensional imaging results showed that the positions of nuclei in giant cells do not fall onto a regular lattice. However, a comparison with model predictions for random positioning showed that the subcellular arrangement of nuclei maintains a low but still detectable degree of ordering. This can be explained by the steric requirements of the microtubule cytoskeleton, as confirmed by the effect of a microtubule degrading drug.
KW  - Dictyostelium
KW  - cell nucleus
KW  - positioning
KW  - imaging
KW  - spatial poisson distribution
Y1  - 2017
U6  - https://doi.org/10.1088/1361-6463/aa8da0
SN  - 0022-3727
SN  - 1361-6463
VL  - 50
IS  - 46
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Das, Debopam
A1  - Taboada, Maite
T1  - Signalling of Coherence Relations in Discourse, Beyond Discourse Markers
JF  - Discourse processes : DP ; a multidisciplinary journal
N2  - We argue that coherence relations (relations between propositions, such as Concession or Purpose) are signalled more frequently and by more means than is generally believed. We examine how coherence relations in text are indicated by all possible textual signals, and whether every relation is signalled. To that end, we conducted a corpus study on the RST Discourse Treebank, a corpus of newspaper articles annotated for rhetorical (or coherence) relations. Results from our corpus study show that most relations in text (over 90%) are signalled and also that most signalled relations (over 80%) are indicated not only by discourse markers (and, but, if, since), but also by a wide variety of signals other than discourse markers, such as reference, lexical, semantic, syntactic and graphical features. These findings suggest that signalling of coherence relations is much more sophisticated than previously thought.
Y1  - 2017
U6  - https://doi.org/10.1080/0163853X.2017.1379327
SN  - 0163-853X
SN  - 1532-6950
VL  - 55
IS  - 8
SP  - 743
EP  - 770
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Milewski, Robert
A1  - Chabrillat, Sabine
A1  - Behling, Robert
T1  - Analyses of Recent Sediment Surface Dynamic of a Namibian Kalahari Salt Pan Based on Multitemporal Landsat and Hyperspectral Hyperion Data
JF  - Remote Sensing
N2  - This study combines spaceborne multitemporal and hyperspectral data to analyze the spatial distribution of surface evaporite minerals and changes in a semi-arid depositional environment associated with episodic flooding events, the Omongwa salt pan (Kalahari, Namibia). The dynamic of the surface crust is evaluated by a change-detection approach using the Iterative-reweighted Multivariate Alteration Detection (IR-MAD) based on the Landsat archive imagery from 1984 to 2015. The results show that the salt pan is a highly dynamic and heterogeneous landform. A change gradient is observed from very stable pan border to a highly dynamic central pan. On the basis of hyperspectral EO-1 Hyperion images, the current distribution of surface evaporite minerals is characterized using Spectral Mixture Analysis (SMA). Assessment of field and image endmembers revealed that the pan surface can be categorized into three major crust types based on diagnostic absorption features and mineralogical ground truth data. The mineralogical crust types are related to different zones of surface change as well as pan morphology that influences brine flow during the pan inundation and desiccation cycles. These combined information are used to spatially map depositional environments where the more dynamic halite crust concentrates in lower areas although stable gypsum and calcite/sepiolite crusts appear in higher elevated areas.
KW  - salt pan
KW  - playa
KW  - hyperspectral
KW  - multitemporal
KW  - change detection
KW  - evaporite minerals
Y1  - 2016
U6  - https://doi.org/10.3390/rs9020170
SN  - 2072-4292
VL  - 9
IS  - 2
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Scholkmann, Antonia
A1  - Siemon, Jens
A1  - Boom, Kay-Dennis
A1  - Knigge, Michel
T1  - Lernzeitnutzung im Planspielunterricht
BT  - Eine Analyse des Einflusses kognitiver Fähigkeiten, Zielorientierungen und Charakteristika von Lernpartnern anhand von Videodaten
JF  - Zeitschrift für Erziehungswissenschaft
N2  - The effective use of learning time is considered one of the most important predictors of successful and good teaching. In the present study we investigated how cognitive skills and goal orientation influenced the effective use of learning time during the open phases of game-based learning We used a newly developed method for video- and audio analysis (German: MuVA), which allowed for reliable documentation of students’ interactions during those phases. The two-step multiple regression model demonstrated that both the learner’s and the learning partner’s goal orientation explain significant parts of the variance: A high performance goal orientation impairs a student’s effective use of learning time, while a high performance avoidance orientation has a positive impact on his or her effective use of learning time. Working with a partner who has a high learning goal orientation or a high work avoidance orientation increases a student’s effective use of his or her learning time, while a high work avoidance orientation on the partner’s side has the opposite effect. Cognitive skills did not influence the effective use of learning time.
N2  - Effektive Lernzeitnutzung gilt als einer der wichtigsten Prädiktoren für erfolgreichen Unterricht. Die vorliegende Studie untersucht in einem dyadischen kooperativen Lernsetting, wie sich die kognitiven Grundfähigkeiten und Zielorientierungen der Partner in den offenen Phasen eines Planspielunterrichts auf die effektive Lernzeitnutzung auswirken. Hierzu nutzten wir die neu entwickelte Multimodale Video- und Audioanalysemethode (MuVA), welche es ermöglicht, Schüler-Interaktionen in offenen Unterrichtsphasen reliabel zu dokumentieren. In zweischrittigen Regressionsmodellen ließ sich aufzeigen, dass sowohl Lernenden- als auch Partnervariablen signifikante Anteile der Varianz erklären: Bei Lernenden selbst beeinflusst eine hohe Leistungszielorientierung die effektive Lernzeitnutzung negativ und eine hohe Vermeidungs-Leistungszielorientierung positiv. Einflüsse durch die Eigenschaften der Lernpartner zeigten sich in positiver Richtung für hohe Ausprägungen der Lern-Zielorientierung und der Vermeidungs-Leistungszielorientierung sowie in negativer Richtung für eine hohe Arbeitsvermeidungsorientierung. Kognitive Grundfähigkeiten hatten keinen Einfluss auf die effektive Lernzeitnutzung.
T2  - Time on task during game-based learning. The effects of cognitive skills, goal orientations and the characteristics of learning partners - an analysis based on video data
KW  - Cognitive skills
KW  - Effective learning time
KW  - Game-based learning
KW  - Goal orientation
KW  - Time on task
KW  - Video analysis
KW  - Videoanalyse
KW  - effektive Lernzeit
KW  - kognitive Grundfähigkeiten
KW  - Zielorientierung
KW  - Planspiel
Y1  - 2017
U6  - https://doi.org/10.1007/s11618-017-0736-4
SN  - 1434-663X
SN  - 1862-5215
VL  - 20
SP  - 651
EP  - 669
PB  - Springer
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Adani, Flavia
A1  - Stegenwallner-Schutz, Maja Henny Katherine
A1  - Niesel, Talea
T1  - The Peaceful Co-existence of Input Frequency and Structural Intervention Effects on the Comprehension of Complex Sentences in German-Speaking Children
JF  - Frontiers in psychology
N2  - The predictions of two contrasting approaches to the acquisition of transitive relative clauses were tested within the same groups of German-speaking participants aged from 3 to 5 years old. The input frequency approach predicts that object relative clauses with inanimate heads (e.g., the pullover that the man is scratching) are comprehended earlier and more accurately than those with an animate head (e.g., the man that the boy is scratching). In contrast, the structural intervention approach predicts that object relative clauses with two full NP arguments mismatching in number (e.g., the man that the boys are scratching) are comprehended earlier and more accurately than those with number-matching NPs (e.g., the man that the boy is scratching). These approaches were tested in two steps. First, we ran a corpus analysis to ensure that object relative clauses with number-mismatching NPs are not more frequent than object relative clauses with number-matching NPs in child directed speech. Next, the comprehension of these structures was tested experimentally in 3-, 4-, and 5-year-olds respectively by means of a color naming task. By comparing the predictions of the two approaches within the same participant groups, we were able to uncover that the effects predicted by the input frequency and by the structural intervention approaches co-exist and that they both influence the performance of children on transitive relative clauses, but in a manner that is modulated by age. These results reveal a sensitivity to animacy mismatch already being demonstrated by 3-year-olds and show that animacy is initially deployed more reliably than number to interpret relative clauses correctly. In all age groups, the animacy mismatch appears to explain the performance of children, thus, showing that the comprehension of frequent object relative clauses is enhanced compared to the other conditions. Starting with 4-year-olds but especially in 5-year-olds, the number mismatch supported comprehension-a facilitation that is unlikely to be driven by input frequency. Once children fine-tune their sensitivity to verb agreement information around the age of four, they are also able to deploy number marking to overcome the intervention effects. This study highlights the importance of testing experimentally contrasting theoretical approaches in order to characterize the multifaceted, developmental nature of language acquisition.
KW  - relative clauses
KW  - sentence comprehension
KW  - input frequency
KW  - number
KW  - animacy
KW  - language acquisition
KW  - German
Y1  - 2017
U6  - https://doi.org/10.3389/fpsyg.2017.01590
SN  - 1664-1078
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wade, Jessica
A1  - Wood, Sebastian
A1  - Collado-Fregoso, Elisa
A1  - Heeney, Martin
A1  - Durrant, James
A1  - Kim, Ji-Seon
T1  - Impact of Fullerene Intercalation on Structural and Thermal Properties of Organic Photovoltaic Blends
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - The performance of organic photovoltaic blend devices is critically dependent on the polymer:fullerene interface. These interfaces are expected to impact the structural and thermal properties of the polymer with regards to the conjugated backbone planarity and transition temperatures during annealing/cooling processes. Here, we report the impact of fullerene intercalation on structural and thermal properties of poly(2,5-bis(3-tetradecylthiophen-2-yOthieno[3,2-b]thiophene (PBTTT), a highly stable material known to exhibit liquid crystalline behavior. We undertake a detailed systematic study of the extent of intercalation in the PBTTT:fullerene blend, considering the use of four different fullerene derivatives and also varying the loading ratios. Resonant Raman spectroscopy allows morphology in situ during controlled heating and cooling. We find that small fullerene molecules readily intercalate into PBTTT crystallites, resulting in a planarization of the polymer backbone, but high fullerene loading ratios or larger fullerenes result in nonintercalated domains. During cooling from melt, nonintercalated blend films are found to return to their original morphology and reproduce all thermal transitions on cooling with minimal hysteresis. Intercalated blend films show significant hysteresis on cooling due to the crystallized fullerene attempting to reintercalate. The strongest hysteresis is for intercalated blend films with excess fullerene loading ratio, which form a distinct nanoribbon morphology and exhibit a reduced geminate recombination rate. These results reveal that careful consideration should be taken during device fabrication, as postdeposition thermal treatments significantly impact the charge generation and recombination dynamics.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.jpcc.7b05893
SN  - 1932-7447
VL  - 121
SP  - 20976
EP  - 20985
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Fer, Istem
A1  - Tietjen, Britta
A1  - Jeltsch, Florian
A1  - Wolff, Christian Michael
T1  - The influence of El Nino-Southern Oscillation regimes on eastern African vegetation and its future implications under the RCP8.5 warming scenario
JF  - Biogeosciences
N2  - The El Nino-Southern Oscillation (ENSO) is the main driver of the interannual variability in eastern African rainfall, with a significant impact on vegetation and agriculture and dire consequences for food and social security. In this study, we identify and quantify the ENSO contribution to the eastern African rainfall variability to forecast future eastern African vegetation response to rainfall variability related to a predicted intensified ENSO. To differentiate the vegetation variability due to ENSO, we removed the ENSO signal from the climate data using empirical orthogonal teleconnection (EOT) analysis. Then, we simulated the ecosystem carbon and water fluxes under the historical climate without components related to ENSO teleconnections. We found ENSO-driven patterns in vegetation response and confirmed that EOT analysis can successfully produce coupled tropical Pacific sea surface temperature-eastern African rainfall teleconnection from observed datasets. We further simulated eastern African vegetation response under future climate change as it is projected by climate models and under future climate change combined with a predicted increased ENSO intensity. Our EOT analysis highlights that climate simulations are still not good at capturing rainfall variability due to ENSO, and as we show here the future vegetation would be different from what is simulated under these climate model outputs lacking accurate ENSO contribution. We simulated considerable differences in eastern African vegetation growth under the influence of an intensified ENSO regime which will bring further environmental stress to a region with a reduced capacity to adapt effects of global climate change and food security.
Y1  - 2017
U6  - https://doi.org/10.5194/bg-14-4355-2017
SN  - 1726-4170
SN  - 1726-4189
VL  - 14
SP  - 4355
EP  - 4374
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Bössenkool, Berry
A1  - Bürger, Gerd
A1  - Heistermann, Maik
T1  - Effects of sample size on estimation of rainfall extremes at high temperatures
JF  - Natural hazards and earth system sciences
N2  - High precipitation quantiles tend to rise with temperature, following the so-called Clausius-Clapeyron (CC) scaling. It is often reported that the CC-scaling relation breaks down and even reverts for very high temperatures. In our study, we investigate this reversal using observational climate data from 142 stations across Germany. One of the suggested meteorological explanations for the breakdown is limited moisture supply. Here we argue that, instead, it could simply originate from undersampling. As rainfall frequency generally decreases with higher temperatures, rainfall intensities as dictated by CC scaling are less likely to be recorded than for moderate temperatures. Empirical quantiles are conventionally estimated from order statistics via various forms of plotting position formulas. They have in common that their largest representable return period is given by the sample size. In small samples, high quantiles are underestimated accordingly. The small-sample effect is weaker, or disappears completely, when using parametric quantile estimates from a generalized Pareto distribution (GPD) fitted with L moments. For those, we obtain quantiles of rainfall intensities that continue to rise with temperature.
Y1  - 2017
U6  - https://doi.org/10.5194/nhess-17-1623-2017
SN  - 1561-8633
VL  - 17
SP  - 1623
EP  - 1629
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Benini, Marco
A1  - Capoferri, Matteo
A1  - Dappiaggi, Claudio
T1  - Hadamard States for Quantum Abelian Duality
JF  - Annales de l'Institut Henri Poincaré
N2  - Abelian duality is realized naturally by combining differential cohomology and locally covariant quantum field theory. This leads to a -algebra of observables, which encompasses the simultaneous discretization of both magnetic and electric fluxes. We discuss the assignment of physically well-behaved states on this algebra and the properties of the associated GNS triple. We show that the algebra of observables factorizes as a suitable tensor product of three -algebras: the first factor encodes dynamical information, while the other two capture topological data corresponding to electric and magnetic fluxes. On the former factor and in the case of ultra-static globally hyperbolic spacetimes with compact Cauchy surfaces, we exhibit a state whose two-point correlation function has the same singular structure of a Hadamard state. Specifying suitable counterparts also on the topological factors, we obtain a state for the full theory, ultimately implementing Abelian duality transformations as Hilbert space isomorphisms.
Y1  - 2017
U6  - https://doi.org/10.1007/s00023-017-0593-y
SN  - 1424-0637
SN  - 1424-0661
VL  - 18
SP  - 3325
EP  - 3370
PB  - Springer
CY  - Basel
ER  - 
TY  - JOUR
A1  - Goychuk, Igor
T1  - Fractional Bhatnagar-Gross-Krook kinetic equation
JF  - The European physical journal : B, Condensed matter and complex systems
N2  - The linear Boltzmann equation approach is generalized to describe fractional superdiffusive transport of the Levy walk type in external force fields. The time distribution between scattering events is assumed to have a finite mean value and infinite variance. It is completely characterized by the two scattering rates, one fractional and a normal one, which defines also the mean scattering rate. We formulate a general fractional linear Boltzmann equation approach and exemplify it with a particularly simple case of the Bohm and Gross scattering integral leading to a fractional generalization of the Bhatnagar, Gross and Krook kinetic equation. Here, at each scattering event the particle velocity is completely randomized and takes a value from equilibrium Maxwell distribution at a given fixed temperature. We show that the retardation effects are indispensable even in the limit of infinite mean scattering rate and argue that this novel fractional kinetic equation provides a viable alternative to the fractional Kramers-Fokker-Planck (KFP) equation by Barkai and Silbey and its generalization by Friedrich et al. based on the picture of divergent mean time between scattering events. The case of divergent mean time is also discussed at length and compared with the earlier results obtained within the fractional KFP. Also a phenomenological fractional BGK equation without retardation effects is proposed in the limit of infinite scattering rates. It cannot be, however, rigorously derived from a scattering model, being rather clever postulated. It this respect, this retardationless equation is similar to the fractional KFP by Barkai and Silbey. However, it corresponds to the opposite, much more physical limit and, therefore, also presents a viable alternative.
Y1  - 2017
U6  - https://doi.org/10.1140/epjb/e2017-80297-x
SN  - 1434-6028
SN  - 1434-6036
VL  - 90
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Baumbach, Lukas
A1  - Siegmund, Jonatan F.
A1  - Mittermeier, Magdalena
A1  - Donner, Reik Volker
T1  - Impacts of temperature extremes on European vegetation during the growing season
JF  - Biogeosciences
N2  - Temperature is a key factor controlling plant growth and vitality in the temperate climates of the mid-latitudes like in vast parts of the European continent. Beyond the effect of average conditions, the timings and magnitudes of temperature extremes play a particularly crucial role, which needs to be better understood in the context of projected future rises in the frequency and/or intensity of such events. In this work, we employ event coincidence analysis (ECA) to quantify the likelihood of simultaneous occurrences of extremes in daytime land surface temperature anomalies (LSTAD) and the normalized difference vegetation index (NDVI). We perform this analysis for entire Europe based upon remote sensing data, differentiating between three periods corresponding to different stages of plant development during the growing season. In addition, we analyze the typical elevation and land cover type of the regions showing significantly large event coincidences rates to identify the most severely affected vegetation types. Our results reveal distinct spatio-temporal impact patterns in terms of extraordinarily large co-occurrence rates between several combinations of temperature and NDVI extremes. Croplands are among the most frequently affected land cover types, while elevation is found to have only a minor effect on the spatial distribution of corresponding extreme weather impacts. These findings provide important insights into the vulnerability of European terrestrial ecosystems to extreme temperature events and demonstrate how event-based statistics like ECA can provide a valuable perspective on environmental nexuses.
Y1  - 2017
U6  - https://doi.org/10.5194/bg-14-4891-2017
SN  - 1726-4170
SN  - 1726-4189
VL  - 14
SP  - 4891
EP  - 4903
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Majda, Mateusz
A1  - Grones, Peter
A1  - Sintorn, Ida-Maria
A1  - Vain, Thomas
A1  - Milani, Pascale
A1  - Krupinski, Pawel
A1  - Zagorska-Marek, Beata
A1  - Viotti, Corrado
A1  - Jonsson, Henrik
A1  - Mellerowicz, Ewa J.
A1  - Hamant, Olivier
A1  - Robert, Stephanie
T1  - Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells
JF  - Developmental cell
N2  - The epidermis of aerial plant organs is thought to be limiting for growth, because it acts as a continuous load-bearing layer, resisting tension. Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been proposed to be a result of subcellular variations in expansion rate that induce local buckling events. Paradoxically, such local compressive buckling should not occur given the tensile stresses across the epidermis. Using computational modeling, we show that the simplest scenario to explain pavement cell shapes within an epidermis under tension must involve mechanical wall heterogeneities across and along the anticlinal pavement cell walls between adjacent cells. Combining genetics, atomic force microscopy, and immunolabeling, we demonstrate that contiguous cell walls indeed exhibit hybrid mechanochemical properties. Such biochemical wall heterogeneities precede wall bending. Altogether, this provides a possible mechanism for the generation of complex plant cell shapes.
Y1  - 2017
U6  - https://doi.org/10.1016/j.devcel.2017.10.017
SN  - 1534-5807
SN  - 1878-1551
VL  - 43
SP  - 290
EP  - +
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Kurze, Susanne
A1  - Heinken, Thilo
A1  - Fartmann, Thomas
T1  - Nitrogen enrichment of host plants has mostly beneficial effects on the life-history traits of nettle-feeding butterflies
JF  - Acta oecologica : international journal of ecology
N2  - Butterflies rank among the most threatened animal groups throughout Europe. However, current population trends differ among species. The nettle-feeding butterflies Aglais io and Aglais urticae cope successfully with the anthropogenic land-use change. Both species are assumed to be pre-adapted to higher nitrogen contents in their host plant, stinging nettle (Urtica dioica). However, it is currently unknown, whether this pre-adaptation enables both Aglais species to cope successfully or even to benefit from the excessive nitrogen availabilities in nettles growing in modern farmlands. For this reason, this study focused on the response of both Aglais species to unfertilized nettles compared to nettles receiving 150 or 300 kg N ha(-1) yr(-1) (i.e., common fertilizer quantities of modern-day agriculture). Fertilized nettles were characterized by higher nitrogen concentrations and lower C:N ratios compared to the control group. In both Aglais species, the individuals feeding on fertilized nettles had higher survival rates, shorter larval periods and heavier pupae and, in A. urticae also longer forewings. All these trait shifts are beneficial for the individuals, lowering their risk to die before reproduction and increasing their reproductive potential. These responses agree with the well-accepted nitrogen-limitation hypothesis predicting a positive relationship between the nitrogen content of the diet and the performance of herbivorous insects. Furthermore, our findings suggest that the increasing abundance of both Aglais species may result not only from the increasing spread of nettles into the farmland but also from changes in their quality due to the eutrophication of the landscape during recent decades.
KW  - Aglais
KW  - Fertilization
KW  - Host-plant quality
KW  - Landscape eutrophication
KW  - Nitrogen-limitation hypothesis
KW  - Rearing experiment
Y1  - 2017
U6  - https://doi.org/10.1016/j.actao.2017.11.005
SN  - 1146-609X
SN  - 1873-6238
VL  - 85
SP  - 157
EP  - 164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Delle Side, Domenico
A1  - Nassisi, Vincenzo
A1  - Pennetta, Cecilia
A1  - Alifano, Pietro
A1  - Di Salvo, Marco
A1  - Tala, Adelfia
A1  - Chechkin, Aleksei V.
A1  - Seno, Flavio
A1  - Trovato, Antonio
T1  - Bacterial bioluminescence onset and quenching: a dynamical model for a quorum sensing-mediated property
JF  - Royal Society Open Science
N2  - We present an effective dynamical model for the onset of bacterial bioluminescence, one of the most studied quorum sensing-mediated traits. Our model is built upon simple equations that describe the growth of the bacterial colony, the production and accumulation of autoinducer signal molecules, their sensing within bacterial cells, and the ensuing quorum activation mechanism that triggers bioluminescent emission. The model is directly tested to quantitatively reproduce the experimental distributions of photon emission times, previously measured for bacterial colonies of Vibrio jasicida, a luminescent bacterium belonging to the Harveyi clade, growing in a highly drying environment. A distinctive and novel feature of the proposed model is bioluminescence ‘quenching’ after a given time elapsed from activation. Using an advanced fitting procedure based on the simulated annealing algorithm, we are able to infer from the experimental observations the biochemical parameters used in the model. Such parameters are in good agreement with the literature data. As a further result, we find that, at least in our experimental conditions, light emission in bioluminescent bacteria appears to originate from a subtle balance between colony growth and quorum activation due to autoinducers diffusion, with the two phenomena occurring on the same time scale. This finding is consistent with a negative feedback mechanism previously reported for Vibrio harveyi.
KW  - quorum sensing
KW  - bioluminescence
KW  - biophysical model
KW  - Vibrio Harveyi clade
KW  - oxygen quenching
KW  - Gompertz growth function
Y1  - 2017
U6  - https://doi.org/10.1098/rsos.171586
SN  - 2054-5703
VL  - 4
PB  - Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Dennis, Alice B.
A1  - Patel, Vilas
A1  - Oliver, Kerry M.
A1  - Vorburger, Christoph
T1  - Parasitoid gene expression changes after adaptation to symbiont-protected hosts
JF  - Evolution
N2  - Reciprocal selection between aphids, their protective endosymbionts, and the parasitoid wasps that prey upon them offers an opportunity to study the basis of their coevolution. We investigated adaptation to symbiont&#8208;conferred defense by rearing the parasitoid wasp Lysiphlebus fabarum on aphids (Aphis fabae) possessing different defensive symbiont strains (Hamiltonella defensa). After ten generations of experimental evolution, wasps showed increased abilities to parasitize aphids possessing the H. defensa strain they evolved with, but not aphids possessing the other strain. We show that the two symbiont strains encode different toxins, potentially creating different targets for counter&#8208;adaptation. Phenotypic and behavioral comparisons suggest that neither life&#8208;history traits nor oviposition behavior differed among evolved parasitoid lineages. In contrast, comparative transcriptomics of adult female wasps identified a suite of differentially expressed genes among lineages, even when reared in a common, symbiont&#8208;free, aphid host. In concurrence with the specificity of each parasitoid lineages’ infectivity, most differentially expressed parasitoid transcripts were also lineage&#8208;specific. These transcripts are enriched with putative venom toxins and contain highly expressed, potentially defensive viral particles. Together, these results suggest that wild populations of L. fabarum employ a complicated offensive arsenal with sufficient genetic variation for wasps to adapt rapidly and specifically to their hosts’ microbial defenses.
KW  - Adaptation
KW  - experimental evolution
KW  - gene expression
KW  - Lysiphlebus fabarum
KW  - parasitoid
KW  - venom
Y1  - 2017
U6  - https://doi.org/10.1111/evo.13333
SN  - 0014-3820
SN  - 1558-5646
VL  - 71
SP  - 2599
EP  - 2617
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Witt, Barbara
A1  - Ebert, Franziska
A1  - Meyer, Sören
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
T1  - Assessing neurodevelopmental effects of arsenolipids in pre-differentiated human neurons
JF  - Molecular nutrition & food research : bioactivity, chemistry, immunology, microbiology, safety, technology
N2  - Scope: In the general population exposure to arsenic occurs mainly via diet. Highest arsenic concentrations are found in seafood, where arsenic is present predominantly in its organic forms including arsenolipids. Since recent studies have provided evidence that arsenolipids could reach the brain of an organism and exert toxicity in fully differentiated human neurons, this work aims to assess the neurodevelopmental toxicity of arsenolipids. Methods and results: Neurodevelopmental effects of three arsenic-containing hydrocarbons (AsHC), two arsenic-containing fatty acids (AsFA), arsenite and dimethylarsinic acid (DMA(V)) were characterized in pre-differentiated human neurons. AsHCs and arsenite caused substantial cytotoxicity in a similar, low concentration range, whereas AsFAs and DMA(V) were less toxic. AsHCs were highly accessible for cells and exerted pronounced neurodevelopmental effects, with neurite outgrowth and the mitochondrial membrane potential being sensitive endpoints; arsenite did not substantially decrease those two endpoints. In fully differentiated neurons, arsenite and AsHCs caused neurite toxicity. Conclusion: These results indicate for a neurodevelopmental potential of AsHCs. Taken into account the possibility that AsHCs might easily reach the developing brain when exposed during early life, neurotoxicity and neurodevelopmental toxicity cannot be excluded. Further studies are needed in order to progress the urgently needed risk assessment.
KW  - Arsenic-containing fatty acids
KW  - Arsenic-containing hydrocarbons
KW  - Arsenite
KW  - Arsenolipids
KW  - Neurodevelopmental toxicity
Y1  - 2017
U6  - https://doi.org/10.1002/mnfr.201700199
SN  - 1613-4125
SN  - 1613-4133
VL  - 61
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Mao, Hailiang
A1  - Aryal, Bibek
A1  - Langenecker, Tobias
A1  - Hagmann, Jorg
A1  - Geisler, Markus
A1  - Grebe, Markus
T1  - Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility
JF  - Nature plants
N2  - The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance.
Y1  - 2017
U6  - https://doi.org/10.1038/s41477-017-0039-z
SN  - 2055-026X
SN  - 2055-0278
VL  - 3
SP  - 854
EP  - 858
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Aichner, Bernhard
A1  - Hilt, Sabine
A1  - Perillon, Cecile
A1  - Gillefalk, Mikael
A1  - Sachse, Dirk
T1  - Biosynthetic hydrogen isotopic fractionation factors during lipid synthesis in submerged aquatic macrophytes: Effect of groundwater discharge and salinity
JF  - Organic geochemistry : the international journal for rapid publication of current research in organic geochemistry and biochemistry
N2  - Sedimentary lipid biomarkers have become widely used tools for reconstructing past climatic and ecological changes due to their ubiquitous occurrence in lake sediments. In particular, the hydrogen isotopic composition (expressed as delta D values) of leaf wax lipids derived from terrestrial plants has been a focus of research during the last two decades and the understanding of competing environmental and plant physiological factors influencing the delta D values has greatly improved. Comparatively less attention has been paid to lipid biomarkers derived from aquatic plants, although these compounds are abundant in many lacustrine sediments. We therefore conducted a field and laboratory experiment to study the effect of salinity and groundwater discharge on the isotopic composition of aquatic plant biomarkers. We analyzed samples of the common submerged plant species, Potamogeton pectinatus (sago pondweed), which has a wide geographic distribution and can tolerate high salinity. We tested the effect of groundwater discharge (characterized by more negative delta D values relative to lake water) and salinity on the delta D values of n-alkanes from P. pectinatus by comparing plants (i) collected from the oligotrophic freshwater Lake Stechlin (Germany) at shallow littoral depth from locations with and without groundwater discharge, and (ii) plants grown from tubers collected from the eutrophic Lake Muggelsee in nutrient solution at four salinity levels. Isotopically depleted groundwater did not have a significant influence on the delta D values of n-alkanes in Lake Stechlin P. pectinatus and calculated isotopic fractionation factors epsilon(l/w) between lake water and n-alkanes averaged -137 +/- 9%(n-C-23), -136 +/- 7%(n-C-25) and -131 +/- 6%(n-C-27), respectively. Similar epsilon values were calculated for plants from Lake Muggelsee grown in freshwater nutrient solution (-134 +/- 11% for n-C-23), while greater fractionation was observed at increased salinity values of 10 (163 +/- 12%) and 15(-172 +/- 15%). We therefore suggest an average e value of -136 +/- 9% between source water and the major n-alkanes in P. pectinatus grown under freshwater conditions. Our results demonstrate that isotopic fractionation can increase by 30-40% at salinity values 10 and 15. These results could be explained either by inhibited plant growth at higher salinity, or by metabolic adaptation to salt stress that remain to be elucidated. A potential salinity effect on dD values of aquatic lipids requires further examination, since this would impact on the interpretation of downcore isotopic data in paleohydrologic studies. (C) 2017 Elsevier Ltd. All rights reserved.
Y1  - 2017
U6  - https://doi.org/10.1016/j.orggeochem.2017.07.021
SN  - 0146-6380
VL  - 113
SP  - 10
EP  - 16
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Romero-Diaz, Cristina
A1  - Breedveld, Merel Cathelijne
A1  - Fitze, Patrick S.
T1  - Climate Effects on Growth, Body Condition, and Survival Depend on the Genetic Characteristics of the Population
JF  - The American naturalist : a bi-monthly journal devoted to the advancement and correlation of the biological sciences
N2  - Climatic change is expected to affect individual life histories and population dynamics, potentially increasing vulnerability to extinction. The importance of genetic diversity has been highlighted for adaptation and population persistence. However, whether responses of life-history traits to a given environmental condition depend on the genetic characteristics of a population remains elusive. Here we tested this hypothesis in the lizard Zootoca vivipara by simultaneously manipulating habitat humidity, a major climatic predictor of Zootoca’s distribution, and adult male color morph frequency, a trait with genome-wide linkage. Interactive effects of humidity and morph frequency had immediate effects on growth and body condition of juveniles and yearlings, as well as on adult survival, and delayed effects on offspring size. In yearlings, higher humidity led to larger female body size and lower humidity led to higher male compared to female survival. In juveniles and yearlings, some treatment effects were compensated over time. The results show that individual responses to environmental conditions depend on the population’s color morph frequency, age class, and sex and that these affect intra– and inter–age class competition. Moreover, humidity affected the competitive environment rather than imposing trait-based selection on specific color morphs. This indicates that species’ responses to changing environments (e.g., to climate change) are highly complex and difficult to accurately reconstruct and predict without information on the genetic characteristics and demographic structure of populations.
KW  - age-structured populations
KW  - age class effects
KW  - life-history traits
KW  - Zootoca vivipara
KW  - humidity
KW  - color morph frequency
Y1  - 2017
U6  - https://doi.org/10.1086/693780
SN  - 0003-0147
SN  - 1537-5323
VL  - 190
SP  - 649
EP  - 662
PB  - Univ. of Chicago Press
CY  - Chicago
ER  - 
TY  - JOUR
A1  - Javanainen, Matti
A1  - Martinez-Seara, Hector
A1  - Metzler, Ralf
A1  - Vattulainen, Ilpo
T1  - Diffusion of Integral Membrane Proteins in Protein-Rich Membranes
JF  - The journal of physical chemistry letters
N2  - The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbruck (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D proportional to ln(1/R). However, instead of being protein-poor, native cell membranes are extremely crowded with proteins. On the basis of extensive molecular simulations, we here demonstrate that protein crowding of the membrane at physiological levels leads to deviations from the SD relation and to the emergence of a stronger Stokes-like dependence D proportional to 1/R. We propose that this 1/R law mainly arises due to geometrical factors: smaller proteins are able to avoid confinement effects much better than their larger counterparts. The results highlight that the lateral dynamics in the crowded setting found in native membranes is radically different from protein-poor conditions and plays a significant role in formation of functional multiprotein complexes.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.jpclett.7b01758
SN  - 1948-7185
VL  - 8
SP  - 4308
EP  - 4313
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Steinhöfel, Grit
A1  - Breuer, Jörn
A1  - von Blanckenburg, Friedhelm
A1  - Horn, Ingo
A1  - Sommer, Michael
T1  - The dynamics of Si cycling during weathering in two small catchments in the Black Forest (Germany) traced by Si isotopes
JF  - Chemical geology : official journal of the European Association for Geochemistry
N2  - Silicon stable isotopes have emerged as a powerful proxy to investigate weathering because Si uptake from solution by secondary minerals or by the vegetation causes significant shifts in the isotope composition. In this study, we determined the Si isotope compositions of the principle Si pools within two small catchments located on sandstone and paragneiss, respectively, in the temperate Black Forest (Germany). At both settings, clay formation is dominated by mineral transformation preserving largely the signature of parental minerals with delta Si-30 values of around -0.7%. Bulk soils rich in primary minerals are similar to bulk parental material with delta Si-30 values close to -0.4%. Topsoils are partly different because organic matter degradation has promoted intense weathering leading to delta Si-30 values as low as -1.0%. Water samples expose highly dynamic weathering processes in the soil zone: 1) after spring snowmelt, increased release of DOC and high water fluxes trigger clay mineral dissolution which leads to delta Si-30 values down to -0.7% and 2) in course of the summer, Si uptake by the vegetation and secondary mineral formation drives dissolved Si to typical positive delta Si-30 values up to 1.1%. Groundwater with delta Si-30 values of around 0.4% records steady processes in bedrock reflecting plagioclase weathering together with kaolinite precipitation. An isotope mass balance approach reveals incongruent weathering conditions where denudation of Si is largely driven by physical erosion. Erosion of phytoliths contributes 3 to 21% to the total Si export flux, which is in the same order as the dissolved Si flux. These results elucidate the Si dynamics during weathering on catchments underlain of sedimentary origin, prevailing on the Earth surface and provide therefore valuable information to interpret the isotope signature of large river systems.
KW  - Weathering
KW  - Sedimentary rocks
KW  - Biogeochemical Si cycle
KW  - Silicon isotopes
KW  - UV femtosecond laser ablation
Y1  - 2017
U6  - https://doi.org/10.1016/j.chemgeo.2017.06.026
SN  - 0009-2541
SN  - 1878-5999
VL  - 466
SP  - 389
EP  - 402
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Chladkova, Katerina
A1  - Hamann, Silke
A1  - Williams, Daniel
A1  - Hellmuth, Sam
T1  - F2 slope as a Perceptual Cue for the Front-Back Contrast in Standard Southern British English
JF  - Language and speech
N2  - Acoustic studies of several languages indicate that second-formant (F2) slopes in high vowels have opposing directions (independent of consonantal context): front [i.]-like vowels are produced with a rising F2 slope, whereas back [u.]-like vowels are produced with a falling F2 slope. The present study first reports acoustic measurements that confirm this pattern for the English variety of Standard Southern British English (SSBE), where /u./ has shifted from the back to the front area of the vowel space and is now realized with higher midpoint F2 values than several decades ago. Subsequently, we test whether the direction of F2 slope also serves as a reliable cue to the /i.// u./ contrast in perception. The findings show that F2 slope direction is used as a cue (additional to midpoint formant values) to distinguish /i./ from /u./by both young and older Standard Southern British English listeners: an otherwise ambiguous token is identified as /i./if it has a rising F2 slope and as /u./if it has a falling F2 slope. Furthermore, our results indicate that listeners generalize their reliance on F2 slope to other contrasts, namely /epsilon/-/./and /ae/-/./, even though F2 slope is not employed to differentiate these vowels in production. This suggests that in Standard Southern British English, a rising F2 seems to be perceptually associated with an abstract feature such as [+ front], whereas a falling F2 with an abstract feature such as [-front].
KW  - perceptual cues
KW  - front-back contrast
KW  - /u./-fronting
KW  - Standard Southern British English
KW  - vowel perception
KW  - phonological feature
Y1  - 2017
U6  - https://doi.org/10.1177/0023830916650991
SN  - 0023-8309
SN  - 1756-6053
VL  - 60
SP  - 377
EP  - 398
PB  - Sage Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Brune, Sascha
A1  - Corti, Giacomo
A1  - Ranalli, Giorgio
T1  - Controls of inherited lithospheric heterogeneity on rift linkage: Numerical and analog models of interaction between the Kenyan and Ethiopian rifts across the Turkana depression
JF  - Tectonics
N2  - Inherited rheological structures in the lithosphere are expected to have large impact on the architecture of continental rifts. The Turkana depression in the East African Rift connects the Main Ethiopian Rift to the north with the Kenya rift in the south. This region is characterized by a NW-SE trending band of thinned crust inherited from a Mesozoic rifting event, which is cutting the present-day N-S rift trend at high angle. In striking contrast to the narrow rifts in Ethiopia and Kenya, extension in the Turkana region is accommodated in subparallel deformation domains that are laterally distributed over several hundred kilometers. We present both analog experiments and numerical models that reproduce the along-axis transition from narrow rifting in Ethiopia and Kenya to a distributed deformation within the Turkana depression. Similarly to natural observations, our models show that the Ethiopian and Kenyan rifts bend away from each other within the Turkana region, thus forming a right-lateral step over and avoiding a direct link to form a continuous N-S depression. The models reveal five potential types of rift linkage across the preexisting basin: three types where rifts bend away from the inherited structure connecting via a (1) wide or (2) narrow rift or by (3) forming a rotating microplate, (4) a type where rifts bend towards it, and (5) straight rift linkage. The fact that linkage type 1 is realized in the Turkana region provides new insights on the rheological configuration of the Mesozoic rift system at the onset of the recent rift episode. Plain Language Summary The Turkana depression in the Kenya/Ethiopia borderland is most famous for its several million years old human fossils, but it also holds a rich geological history of continental separation. The Turkana region is a lowland located between the East African and Ethiopian domes because its crust and mantle have been stretched in a continent-wide rift event during Cretaceous times about 140-120 Ma ago. This thin lithosphere exerted paramount control on the dynamics of East African rifting in this area, which commenced around 15 Ma ago and persists until today. Combining analog "sandbox" experiments with numerical geodynamic modeling, we find that inherited rift structures explain the dramatic change in rift style from deep, narrow rift basins north and south of the Turkana area to wide, distributed deformation within the Turkana depression. The failed Cretaceous rift is also responsible for the eastward bend of the Ethiopian rift and the westward bend of the Kenyan rift when entering the Turkana depression, which generated the characteristic hook-shaped form of present-day Lake Turkana. Combing two independent modeling techniques-analog and numerical experiments-is a very promising approach allowing to draw robust conclusions about the processes that shape the surface of our planet.
KW  - continental rifting
KW  - east African rift
KW  - numerical modeling
KW  - analog modeling
KW  - tectonic inheritance
KW  - Turkana depression
Y1  - 2017
U6  - https://doi.org/10.1002/2017TC004739
SN  - 0278-7407
SN  - 1944-9194
VL  - 36
SP  - 1767
EP  - 1786
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Jap, Bernard A. J.
A1  - Borleffs, Elisabeth
A1  - Maassen, Ben A. M.
T1  - Towards identifying dyslexia in Standard Indonesian: the development of a reading assessment battery
JF  - Reading and writing : an interdisciplinary journal
KW  - Standard Indonesian
KW  - Dyslexia
KW  - Transparent orthography
KW  - Dyslexia assessment
Y1  - 2017
U6  - https://doi.org/10.1007/s11145-017-9748-y
SN  - 0922-4777
SN  - 1573-0905
VL  - 30
SP  - 1729
EP  - 1751
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Ruzanska, Ulrike Alexandra
A1  - Warschburger, Petra
T1  - Psychometric evaluation of the German version of the Intuitive Eating Scale-2 in a community sample
JF  - Appetite : multidisciplinary research on eating and drinking
KW  - Intuitive eating scale
KW  - Healthy eating behavior
KW  - Psychometric properties
KW  - Disordered eating
Y1  - 2017
U6  - https://doi.org/10.1016/j.appet.2017.06.018
SN  - 0195-6663
SN  - 1095-8304
VL  - 117
SP  - 126
EP  - 134
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Algharably, Engi A. H.
A1  - Bolbrinker, Juliane
A1  - Lezius, Susanne
A1  - Reibis, Rona Katharina
A1  - Wegscheider, Karl
A1  - Völler, Heinz
A1  - Kreutz, Reinhold
T1  - Uromodulin associates with cardiorenal function in patients with hypertension and cardiovascular disease
JF  - Journal of hypertension
N2  - Objective:Common genetic variants in the gene encoding uromodulin (UMOD) have been associated with renal function, blood pressure (BP) and hypertension. We investigated the associations between an important single nucleotide polymorphism (SNP) in UMOD, that is rs12917707-G>T, and estimated glomerular filtration rate (eGFR), BP and cardiac organ damage as determined by echocardiography in patients with arterial hypertension.Methods:A cohort of 1218 treated high-risk patients (mean age 58.5 years, 83% men) with documented cardiovascular disease (81% with coronary heart disease) was analysed.Results:The mean values for 24-h SBP and DBP were 124.714.7 and 73.9 +/- 9.4mmHg; mean eGFR was 77.5 +/- 18.3ml/min per 1.73m(2), mean left ventricular ejection fraction was 59.3 +/- 9.9% and mean left ventricular mass index in men and women was 53.9 +/- 23.2 and 54.9 +/- 23.7g/m(2.7) with 50.4% of patients having left ventricular hypertrophy. A significant association between rs12917707 and eGFR was observed with T-allele carriers showing significantly higher eGFR values (+2.6ml/min per 1.73m(2), P=0.006) than noncarriers. This SNP associated also with left atrial diameter (P=0.007); homozygous carriers of the T-allele had smaller left atrial diameter (-1.5mm) than other genotype groups (P=0.040). No significant associations between rs12917707 and other cardiac or BP phenotypes were observed.Conclusions:These findings extend the previously documented role of UMOD for renal function also to treated high-risk patients with arterial hypertension and reveal a novel association with left atrial remodelling and thus a potential cardiorenal link modulated by UMOD.
KW  - blood pressure
KW  - cardiovascular complications
KW  - chronic kidney disease
KW  - genetics
KW  - hypertension
KW  - kidney function
KW  - organ damage
KW  - Tamm-Horsfall protein
Y1  - 2017
U6  - https://doi.org/10.1097/HJH.0000000000001432
SN  - 0263-6352
SN  - 1473-5598
VL  - 35
SP  - 2053
EP  - 2058
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Janhunen, Tomi
A1  - Kaminski, Roland
A1  - Ostrowski, Max
A1  - Schellhorn, Sebastian
A1  - Wanko, Philipp
A1  - Schaub, Torsten H.
T1  - Clingo goes linear constraints over reals and integers
JF  - Theory and practice of logic programming
N2  - The recent series 5 of the Answer Set Programming (ASP) system clingo provides generic means to enhance basic ASP with theory reasoning capabilities. We instantiate this framework with different forms of linear constraints and elaborate upon its formal properties. Given this, we discuss the respective implementations, and present techniques for using these constraints in a reactive context. More precisely, we introduce extensions to clingo with difference and linear constraints over integers and reals, respectively, and realize them in complementary ways. Finally, we empirically evaluate the resulting clingo derivatives clingo[dl] and clingo[lp] on common language fragments and contrast them to related ASP systems.
KW  - Constraint Answer Set Programming (CASP)
KW  - Answer Set Programming (ASP)
KW  - Constraint Processing (CP)
KW  - Theory Solving
Y1  - 2017
U6  - https://doi.org/10.1017/S1471068417000242
SN  - 1471-0684
SN  - 1475-3081
VL  - 17
SP  - 872
EP  - 888
PB  - Cambridge Univ. Press
CY  - New York
ER  - 
TY  - JOUR
A1  - Palyulin, Vladimir V.
A1  - Mantsevich, Vladimir N.
A1  - Klages, Rainer
A1  - Metzler, Ralf
A1  - Chechkin, Aleksei V.
T1  - Comparison of pure and combined search strategies for single and multiple targets
JF  - The European physical journal : B, Condensed matter and complex systems
N2  - We address the generic problem of random search for a point-like target on a line. Using the measures of search reliability and efficiency to quantify the random search quality, we compare Brownian search with Levy search based on long-tailed jump length distributions. We then compare these results with a search process combined of two different long-tailed jump length distributions. Moreover, we study the case of multiple targets located by a Levy searcher.
Y1  - 2017
U6  - https://doi.org/10.1140/epjb/e2017-80372-4
SN  - 1434-6028
SN  - 1434-6036
VL  - 90
SP  - 20
EP  - 37
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Scheel, Tabea
A1  - Hoeppner, Dorothea
A1  - Grotevendt, Anne
A1  - Barthlen, Winfried
T1  - Clowns in Paediatric Surgery: Less Anxiety and More Oxytocin? A Pilot Study
JF  - Klinische Pädiatrie : clinical research and practice in pediatrics
N2  - Background Hospital stays and medical interventions are accompanied by worries and anxiety in children and parents. Recent studies show that hospital clowns may reduce anxiety and enhance well-being. However, so far studies are based solely on subjective measures and clowns are usually not integrated in medical routine. With this pilot study, we aim to provide both psychological and physiological evidence of positive effects of clowns’ interventions in hospitalized children.

Patients/Method In a consecutive randomized intervention-control group design with 31 children aged 4 to 13 years, 17 patients were accompanied by a clown prior to surgery or during ward round (intervention group) and 14 were not (control group). Saliva samples for oxytocin measurement were taken from all patients before hospitalization (T1) and prior to surgery or after ward round (T2). Self- and parents-reports were obtained at T1, T2 as well as at time of discharge from hospital (T3) regarding children’s anxiety (STAI), worries and well-being. Clowns evaluated their success in cheering up the child. Health professionals were asked for their acceptance of clowns in hospitals.

Results Children in the intervention group had lower anxiety ratings and a higher oxytocin concentration at T2 as compared with T1; the control group showed no changes. Parents rated the well-being of their children higher if their child had clown’s contact and were more willing to recommend the hospital. The staff judged the clowns as helpful for patients.

Discussion Consistent psychological and physiological results suggest the positive impact of a clown’s intervention in hospitalized children.
KW  - hospital clowns
KW  - medical routine
KW  - oxytocine
KW  - psychological well-being
KW  - anxiety
KW  - childcare
Y1  - 2017
U6  - https://doi.org/10.1055/s-0043-106854
SN  - 0300-8630
SN  - 1439-3824
VL  - 229
SP  - 274
EP  - 280
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Fudickar, Werner
A1  - Linker, Torsten
T1  - Synthesis of Pyridylanthracenes and Their Reversible Reaction with Singlet Oxygen to Endoperoxides
JF  - The journal of organic chemistry
N2  - The ortho, meta, and para isomers of 9,10-dipyridylanthracene 1 have been synthesized and converted into their endoperoxides 1-O-2 upon oxidation with singlet oxygen. The kinetics of this reaction can be controlled by the substitution pattern and the solvent: in highly polar solvents, the meta isomer is the most reactive, whereas the ortho isomer is oxidized fastest in nonpolar solvents. Heating of the endoperoxides affords the parent anthracenes by release of singlet oxygen.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.joc.7b01765
SN  - 0022-3263
VL  - 82
SP  - 9258
EP  - 9262
PB  - American Chemical Society
CY  - Washington
ER  -