TY - JOUR A1 - Fernando, Raquel A1 - Drescher, Cathleen A1 - Nowotny, Kerstin A1 - Grune, Tilman A1 - Castro, Jose Pedro T1 - Impaired proteostasis during skeletal muscle aging JF - Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research N2 - Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The skeletal muscle is one of the earliest tissues to be affected and to manifest age-related changes such as functional impairment and the loss of mass. Common to these alterations and to most of tissues during aging is the disruption of the proteostasis network by detrimental changes in the ubiquitin-proteasomal system (UPS) and the autophagy-lysosomal system (ALS). In fact, during aging the accumulation of protein aggregates, a process mainly driven by increased levels of oxidative stress, has been observed, clearly demonstrating UPS and ALS dysregulation. Since the UPS and ALS are the two most important pathways for the removal of misfolded and aggregated proteins and also of damaged organelles, we provide here an overview on the current knowledge regarding the connection between the loss of proteostasis and skeletal muscle functional impairment and also how redox regulation can play a role during aging. Therefore, this review serves for a better understanding of skeletal muscle aging in regard to the loss of proteostasis and how redox regulation can impact its function and maintenance. KW - Skeletal muscle KW - Proteostasis KW - Proteasome and lysosome KW - Oxidative stress KW - Redox regulation KW - Aging Y1 - 2018 U6 - https://doi.org/10.1016/j.freeradbiomed.2018.08.037 SN - 0891-5849 SN - 1873-4596 VL - 132 SP - 58 EP - 66 PB - Elsevier CY - New York ER -