TY  - JOUR
A1  - Büchner, Dörthe
A1  - John, Leonard
A1  - Mertens, Monique
A1  - Wessig, Pablo
T1  - Detection of dsDNA with [1,3]Dioxolo[4,5-f]benzodioxol (DBD) Dyes
JF  - Chemistry - a European journal
N2  - DBD fluorescent dyes have proven to be useful in numerous applications. To widen the range of biological applications, we propose three different types of DBD molecules that have been modified in such a way that DNA interaction becomes probable. After the successful synthesis of all three compounds, we tested their fluorescent properties and their DNA binding abilities. Two of the three probes exhibit an interaction with dsDNA with subsequent fluorescence enhancement. The determined binding constants of the two new DNA dyes are comparable to other minorgroove-binding dyes. Their large Stokes shifts and their long fluorescent lifetimes are outstanding features of these dyes.
KW  - DNA recognition
KW  - dyes/pigments
KW  - fluorescent probes
KW  - heterocycles
KW  - scatchard plot
Y1  - 2018
U6  - https://doi.org/10.1002/chem.201804057
SN  - 0947-6539
SN  - 1521-3765
VL  - 24
IS  - 60
SP  - 16183
EP  - 16190
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schultze, Christiane
A1  - Schmidt, Bernd
T1  - Ring-closing-metathesis-based synthesis of annellated coumarins from 8-allylcoumarins
JF  - Beilstein journal of organic chemistry
N2  - 8-Allylcoumarins are conveniently accessible through a microwave-promoted tandem Claisen rearrangement/Wittig olefination/cyclization sequence. They serve as a versatile platform for the annellation of five- to seven-membered rings using ring-closing olefin metathesis (RCM). Furano-, pyrano-, oxepino- and azepinocoumarins were synthesized from the same set of precursors using Ru-catalyzed double bond isomerizations and RCM in a defined order. One class of products, pyrano[2,3-f]chromene-2,8-diones, were inaccessible through direct RCM of an acrylate, but became available from the analogous allyl ether via an assisted tandem catalytic RCM/allylic oxidation sequence.
KW  - coumarins
KW  - heterocycles
KW  - isomerization
KW  - olefin metathesis
KW  - ruthenium
Y1  - 2018
U6  - https://doi.org/10.3762/bjoc.14.278
SN  - 1860-5397
VL  - 14
SP  - 2991
EP  - 2998
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  -