TY - JOUR A1 - Démaris, Alix A1 - Widigson, Ella S. K. A1 - Ilvemark, Johan F. K. F. A1 - Steenholdt, Casper A1 - Seidelin, Jakob B. A1 - Huisinga, Wilhelm A1 - Michelet, Robin A1 - Aulin, Linda B. S. A1 - Kloft, Charlotte T1 - Ulcerative colitis and acute severe ulcerative colitis patients are overlooked in infliximab population pharmacokinetic models BT - results from a comprehensive review JF - Pharmaceutics / Molecular Diversity Preservation International N2 - Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis alpha monoclonal antibodies, including infliximab (IFX). Even though treatment of UC patients by IFX has been in place for over a decade, many gaps in modelling of IFX PK in this population remain. This is even more true for acute severe UC (ASUC) patients for which early prediction of IFX pharmacokinetic (PK) could highly improve treatment outcome. Thus, this review aims to compile and analyse published population PK models of IFX in UC and ASUC patients, and to assess the current knowledge on disease activity impact on IFX PK. For this, a semi-systematic literature search was conducted, from which 26 publications including a population PK model analysis of UC patients receiving IFX therapy were selected. Amongst those, only four developed a model specifically for UC patients, and only three populations included severe UC patients. Investigations of disease activity impact on PK were reported in only 4 of the 14 models selected. In addition, the lack of reported model codes and assessment of predictive performance make the use of published models in a clinical setting challenging. Thus, more comprehensive investigation of PK in UC and ASUC is needed as well as more adequate reports on developed models and their evaluation in order to apply them in a clinical setting. KW - infliximab KW - inflammatory bowel disease KW - ulcerative colitis KW - acute severe KW - disease activity KW - pharmacokinetic KW - pharmacometrics Y1 - 2022 U6 - https://doi.org/10.3390/pharmaceutics14102095 SN - 1999-4923 VL - 14 IS - 10 PB - MDPI CY - Basel ER - TY - JOUR A1 - Choudhury, Arnab A1 - DeVine, Jessalyn A. A. A1 - Sinha, Shreya A1 - Lau, Jascha Alexander A1 - Kandratsenka, Alexander A1 - Schwarzer, Dirk A1 - Saalfrank, Peter A1 - Wodtke, Alec Michael T1 - Condensed-phase isomerization through tunnelling gateways JF - Nature : the international weekly journal of science N2 - Quantum mechanical tunnelling describes transmission of matter waves through a barrier with height larger than the energy of the wave(1). Tunnelling becomes important when the de Broglie wavelength of the particle exceeds the barrier thickness; because wavelength increases with decreasing mass, lighter particles tunnel more efficiently than heavier ones. However, there exist examples in condensed-phase chemistry where increasing mass leads to increased tunnelling rates(2). In contrast to the textbook approach, which considers transitions between continuum states, condensed-phase reactions involve transitions between bound states of reactants and products. Here this conceptual distinction is highlighted by experimental measurements of isotopologue-specific tunnelling rates for CO rotational isomerization at an NaCl surface(3,4), showing nonmonotonic mass dependence. A quantum rate theory of isomerization is developed wherein transitions between sub-barrier reactant and product states occur through interaction with the environment. Tunnelling is fastest for specific pairs of states (gateways), the quantum mechanical details of which lead to enhanced cross-barrier coupling; the energies of these gateways arise nonsystematically, giving an erratic mass dependence. Gateways also accelerate ground-state isomerization, acting as leaky holes through the reaction barrier. This simple model provides a way to account for tunnelling in condensed-phase chemistry, and indicates that heavy-atom tunnelling may be more important than typically assumed. Y1 - 2022 U6 - https://doi.org/10.1038/s41586-022-05451-0 SN - 0028-0836 SN - 1476-4687 VL - 612 IS - 7941 SP - 691 EP - 695 PB - Macmillan Publishers Limited, part of Springer Nature CY - London ER - TY - JOUR A1 - Rolph, Rebecca A1 - Overduin, Pier Paul A1 - Ravens, Thomas A1 - Lantuit, Hugues A1 - Langer, Moritz T1 - ArcticBeach v1.0 BT - a physics-based parameterization of pan-Arctic coastline erosion JF - Frontiers in Earth Science N2 - In the Arctic, air temperatures are increasing and sea ice is declining, resulting in larger waves and a longer open water season, all of which intensify the thaw and erosion of ice-rich coasts. Climate change has been shown to increase the rate of Arctic coastal erosion, causing problems for Arctic cultural heritage, existing industrial, military, and civil infrastructure, as well as changes in nearshore biogeochemistry. Numerical models that reproduce historical and project future Arctic erosion rates are necessary to understand how further climate change will affect these problems, and no such model yet exists to simulate the physics of erosion on a pan-Arctic scale. We have coupled a bathystrophic storm surge model to a simplified physical erosion model of a permafrost coastline. This Arctic erosion model, called ArcticBeach v1.0, is a first step toward a physical parameterization of Arctic shoreline erosion for larger-scale models. It is forced by wind speed and direction, wave period and height, sea surface temperature, all of which are masked during times of sea ice cover near the coastline. Model tuning requires observed historical retreat rates (at least one value), as well as rough nearshore bathymetry. These parameters are already available on a pan-Arctic scale. The model is validated at three study sites at 1) Drew Point (DP), Alaska, 2) Mamontovy Khayata (MK), Siberia, and 3) Veslebogen Cliffs, Svalbard. Simulated cumulative retreat rates for DP and MK respectively (169 and 170 m) over the time periods studied at each site (2007-2016, and 1995-2018) are found to the same order of magnitude as observed cumulative retreat (172 and 120 m). The rocky Veslebogen cliffs have small observed cumulative retreat rates (0.05 m over 2014-2016), and our model was also able to reproduce this same order of magnitude of retreat (0.08 m). Given the large differences in geomorphology between the study sites, this study provides a proof-of-concept that ArcticBeach v1.0 can be applied on very different permafrost coastlines. ArcticBeach v1.0 provides a promising starting point to project retreat of Arctic shorelines, or to evaluate historical retreat in places that have had few observations. KW - permafrost KW - erosion KW - modelling KW - arctic KW - climate change Y1 - 2022 U6 - https://doi.org/10.3389/feart.2022.962208 SN - 2296-6463 VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Poelking, Carl A1 - Benduhn, Johannes A1 - Spoltore, Donato A1 - Schwarze, Martin A1 - Roland, Steffen A1 - Piersimoni, Fortunato A1 - Neher, Dieter A1 - Leo, Karl A1 - Vandewal, Koen A1 - Andrienko, Denis T1 - Open-circuit voltage of organic solar cells BT - interfacial roughness makes the difference JF - Communications physics N2 - Organic photovoltaics (PV) is an energy-harvesting technology that offers many advantages, such as flexibility, low weight and cost, as well as environmentally benign materials and manufacturing techniques. Despite growth of power conversion efficiencies to around 19 % in the last years, organic PVs still lag behind inorganic PV technologies, mainly due to high losses in open-circuit voltage. Understanding and improving open circuit voltage in organic solar cells is challenging, as it is controlled by the properties of a donor-acceptor interface where the optical excitations are separated into charge carriers. Here, we provide an electrostatic model of a rough donor-acceptor interface and test it experimentally on small molecule PV materials systems. The model provides concise relationships between the open-circuit voltage, photovoltaic gap, charge-transfer state energy, and interfacial morphology. In particular, we show that the electrostatic bias generated across the interface reduces the photovoltaic gap. This negative influence on open-circuit voltage can, however, be circumvented by adjusting the morphology of the donor-acceptor interface. Organic solar cells, despite their high power conversion efficiencies, suffer from open circuit voltage losses making them less appealing in terms of applications. Here, the authors, supported with experimental data on small molecule photovoltaic cells, relate open circuit voltage to photovoltaic gap, charge-transfer state energy, and donor-acceptor interfacial morphology. Y1 - 2022 U6 - https://doi.org/10.1038/s42005-022-01084-x SN - 2399-3650 VL - 5 IS - 1 PB - Nature portfolio CY - Berlin ER - TY - JOUR A1 - Kölsch, Maximilian A1 - Dietrich, Tim A1 - Ujevic, Maximiliano A1 - Brügmann, Bernd T1 - Investigating the mass-ratio dependence of the prompt-collapse threshold with numerical-relativity simulations JF - Physical review : D, Particles, fields, gravitation, and cosmology N2 - The next observing runs of advanced gravitational-wave detectors will lead to a variety of binary neutron star detections and numerous possibilities for multimessenger observations of binary neutron star systems. In this context a clear understanding of the merger process and the possibility of prompt black hole formation after merger is important, as the amount of ejected material strongly depends on the merger dynamics. These dynamics are primarily affected by the total mass of the binary, however, the mass ratio also influences the postmerger evolution. To determine the effect of the mass ratio, we investigate the parameter space around the prompt-collapse threshold with a new set of fully relativistic simulations. The simulations cover three equations of state and seven mass ratios in the range of 1.0 <= q <= 1.75, with five to seven simulations of binary systems of different total mass in each case. The threshold mass is determined through an empirical relation based on the collapse time, which allows us to investigate effects of the mass ratio on the threshold mass and also on the properties of the remnant system. Furthermore, we model effects of mass ratio and equation of state on tidal parameters of threshold configurations. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevD.106.044026 SN - 2470-0010 SN - 2470-0029 VL - 106 IS - 4 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Hébert, Raphaël A1 - Herzschuh, Ulrike A1 - Laepple, Thomas T1 - Millennial-scale climate variability over land overprinted by ocean temperature fluctuations JF - Nature geoscience N2 - Variations in regional temperature have widespread implications for society, but our understanding of the amplitude and origin of long-term natural variability is insufficient for accurate regional projections. This is especially the case for terrestrial temperature variability, which is currently thought to be weak over long timescales. By performing spectral analysis on climate reconstructions, produced using sedimentary pollen records from the Northern Hemisphere over the last 8,000 years, coupled with instrumental data, we provide a comprehensive estimate of regional temperature variability from annual to millennial timescales. We show that short-term random variations are overprinted by strong ocean-driven climate variability on multi-decadal and longer timescales. This may cause substantial and potentially unpredictable regional climatic shifts in the coming century, in contrast to the relatively muted and homogeneous warming projected by climate models. Due to the marine influence, regions characterized by stable oceanic climate at sub-decadal timescales experience stronger long-term variability, and continental regions with higher sub-decadal variability show weaker long-term variability. This fundamental relationship between the timescales provides a unique insight into the emergence of a marine-driven low-frequency regime governing terrestrial climate variability and sets the basis to project the amplitude of temperature fluctuations on multi-decadal timescales and longer. Temperature variability over land is enhanced by ocean temperature fluctuations on millennial timescales, with implications for regional-scale climate change, according to an analysis of Northern Hemisphere proxy records and observations. Y1 - 2022 U6 - https://doi.org/10.1038/s41561-022-01056-4 SN - 1752-0894 SN - 1752-0908 VL - 15 IS - 11 SP - 899 PB - Nature portfolio CY - Berlin ER - TY - JOUR A1 - Schaffenroth, Veronika A1 - Pelisoli, Ingrid A1 - Barlow, Brad N. A1 - Geier, Stephan A1 - Kupfer, Thomas T1 - Hot subdwarfs in close binaries observed from space I. BT - orbital, atmospheric, and absolute parameters and the nature of their companions JF - Astronomy and astrophysics : an international weekly journal N2 - Context: About a third of the hot subdwarfs of spectral type B (sdBs), which are mostly core-helium-burning objects on the extreme horizontal branch, are found in close binaries with cool, low-mass stellar, substellar, or white dwarf companions. They can show light variations due to di fferent phenomena. Aims: Many hot subdwarfs now have space-based light curves with a high signal-to-noise ratio available. We used light curves from the Transiting Exoplanet Survey Satellite and the K2 space mission to look for more sdB binaries. Their light curves can be used to study the hot subdwarf primaries and their companions, and obtained orbital, atmospheric, and absolute parameters for those systems, when combined with other analysis methods. Methods: By classifying the light variations and combining these with the fit of the spectral energy distribution, the distance derived by the parallaxes obtained by Gaia, and the atmospheric parameters, mainly from the literature, we could derive the nature of the primaries and secondaries in 122 (75%) of the known sdB binaries and 82 newly found reflection e ffect systems. We derived absolute masses, radii, and luminosities for a total of 39 hot subdwarfs with cool, low-mass companions, as well 29 known and newly found sdBs with white dwarf companions. Results: The mass distribution of hot subdwarfs with cool, low-mass stellar and substellar companions, di ffers from those with white dwarf companions, implying they come from di fferent populations. By comparing the period and minimum companion mass distributions, we find that the reflection e ffect systems all have M dwarf or brown dwarf companions, and that there seem to be several di fferent populations of hot subdwarfs with white dwarf binaries - one with white dwarf minimum masses around 0.4 M-circle dot, one with longer periods and minimum companion masses up to 0.6 M-circle dot, and at the shortest period, another with white dwarf minimum masses around 0.8 M-circle dot. We also derive the first orbital period distribution for hot subdwarfs with cool, low-mass stellar or substellar systems selected from light variations instead of radial velocity variations. It shows a narrower period distribution, from 1.5 h to 35 h, compared to the distribution of hot subdwarfs with white dwarfs, which ranges from 1 h to 30 days. These period distributions can be used to constrain the previous common-envelope phase. KW - binaries: close KW - subdwarfs KW - white dwarfs KW - stars: late-type KW - stars: KW - horizontal-branch KW - stars: fundamental parameters Y1 - 2022 U6 - https://doi.org/10.1051/0004-6361/202244214 SN - 0004-6361 SN - 1432-0746 VL - 666 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Adolfs, Marjolijn A1 - Hoque, Mohammed Mainul A1 - Shprits, Yuri T1 - Storm-time relative total electron content modelling using machine learning techniques JF - Remote sensing N2 - Accurately predicting total electron content (TEC) during geomagnetic storms is still a challenging task for ionospheric models. In this work, a neural-network (NN)-based model is proposed which predicts relative TEC with respect to the preceding 27-day median TEC, during storm time for the European region (with longitudes 30 degrees W-50 degrees E and latitudes 32.5 degrees N-70 degrees N). The 27-day median TEC (referred to as median TEC), latitude, longitude, universal time, storm time, solar radio flux index F10.7, global storm index SYM-H and geomagnetic activity index Hp30 are used as inputs and the output of the network is the relative TEC. The relative TEC can be converted to the actual TEC knowing the median TEC. The median TEC is calculated at each grid point over the European region considering data from the last 27 days before the storm using global ionosphere maps (GIMs) from international GNSS service (IGS) sources. A storm event is defined when the storm time disturbance index Dst drops below 50 nanotesla. The model was trained with storm-time relative TEC data from the time period of 1998 until 2019 (2015 is excluded) and contains 365 storms. Unseen storm data from 33 storm events during 2015 and 2020 were used to test the model. The UQRG GIMs were used because of their high temporal resolution (15 min) compared to other products from different analysis centers. The NN-based model predictions show the seasonal behavior of the storms including positive and negative storm phases during winter and summer, respectively, and show a mixture of both phases during equinoxes. The model's performance was also compared with the Neustrelitz TEC model (NTCM) and the NN-based quiet-time TEC model, both developed at the German Aerospace Agency (DLR). The storm model has a root mean squared error (RMSE) of 3.38 TEC units (TECU), which is an improvement by 1.87 TECU compared to the NTCM, where an RMSE of 5.25 TECU was found. This improvement corresponds to a performance increase by 35.6%. The storm-time model outperforms the quiet-time model by 1.34 TECU, which corresponds to a performance increase by 28.4% from 4.72 to 3.38 TECU. The quiet-time model was trained with Carrington averaged TEC and, therefore, is ideal to be used as an input instead of the GIM derived 27-day median. We found an improvement by 0.8 TECU which corresponds to a performance increase by 17% from 4.72 to 3.92 TECU for the storm-time model using the quiet-time-model predicted TEC as an input compared to solely using the quiet-time model. KW - ionosphere KW - relative total electron content KW - geomagnetic storms KW - neural KW - networks KW - NTCM KW - European storm-time model Y1 - 2022 U6 - https://doi.org/10.3390/rs14236155 SN - 2072-4292 VL - 14 IS - 23 PB - MDPI CY - Basel ER - TY - JOUR A1 - Deeken, Friederike A1 - Rapp, Michael A. T1 - Technology-based interventions as an approach to treating apathy in people with dementia JF - International psychogeriatrics : the official journal of the International Psychogeriatric Association Y1 - 2022 U6 - https://doi.org/10.1017/S1041610222000035 SN - 1741-203X VL - 34 IS - 2 SP - 95 EP - 96 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Weinstein, Theresa Julia A1 - Ceh, Simon Majed A1 - Meinel, Christoph A1 - Benedek, Mathias T1 - What's creative about sentences? BT - a computational approach to assessing creativity in a sentence generation task JF - Creativity Research Journal N2 - Evaluating creativity of verbal responses or texts is a challenging task due to psychometric issues associated with subjective ratings and the peculiarities of textual data. We explore an approach to objectively assess the creativity of responses in a sentence generation task to 1) better understand what language-related aspects are valued by human raters and 2) further advance the developments toward automating creativity evaluations. Over the course of two prior studies, participants generated 989 four-word sentences based on a four-letter prompt with the instruction to be creative. We developed an algorithm that scores each sentence on eight different metrics including 1) general word infrequency, 2) word combination infrequency, 3) context-specific word uniqueness, 4) syntax uniqueness, 5) rhyme, 6) phonetic similarity, and similarity of 7) sequence spelling and 8) semantic meaning to the cue. The text metrics were then used to explain the averaged creativity ratings of eight human raters. We found six metrics to be significantly correlated with the human ratings, explaining a total of 16% of their variance. We conclude that the creative impression of sentences is partly driven by different aspects of novelty in word choice and syntax, as well as rhythm and sound, which are amenable to objective assessment. Y1 - 2022 U6 - https://doi.org/10.1080/10400419.2022.2124777 SN - 1040-0419 SN - 1532-6934 VL - 34 IS - 4 SP - 419 EP - 430 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Sotiropoulou, Stavroula A1 - Gafos, Adamantios I. T1 - Phonetic indices of syllabic organization in German stop-lateral clusters JF - Laboratory Phonology N2 - Using articulatory data from five German speakers, we study how segmental sequences under different syllabic organizations respond to perturbations of phonetic parameters in the segments that compose them. Target words contained stop-lateral sequences /bl, gl, kl, pl/ in word-initial and cross-word contexts and were embedded in carrier phrases with different prosodic boundaries, i.e., no phrase boundary versus an utterance phrase boundary preceded the target word in the case of word-initial clusters, or separated the consonants in the case of cross-word sequences. For word-initial cluster (CCV) onsets, we find that increasing C1 stop duration or the lag between two consonants leads to earlier vowel initiation and reduced local timing stability across CV, CCV. Furthermore, as the inter-consonantal lag increases, C2 duration decreases. In contrast, for cross-word C#CV sequences, increasing inter-consonantal lag does not lead to earlier vowel initiation and robust local timing stability is maintained across CV, C#CV. In other words, in CCV sequences within words, local perturbations to segments have effects that ripple through the rest of the sequence. Instead, in cross-word C#CV sequences, local perturbations stay local. Overall, the findings indicate that the effects of phonetic perturbations on coordination patterns depend on the syllabic organization superimposed on these clusters. Y1 - 2022 U6 - https://doi.org/10.16995/labphon.6440 SN - 1868-6346 SN - 1868-6354 VL - 13 IS - 1 PB - Open Library of humanities CY - Cambridge ER - TY - JOUR A1 - Nassar, Yomna M. A1 - Hohmann, Nicolas A1 - Michelet, Robin A1 - Gottwalt, Katharina A1 - Meid, Andreas D. A1 - Burhenne, Jürgen A1 - Huisinga, Wilhelm A1 - Haefeli, Walter E. A1 - Mikus, Gerd A1 - Kloft, Charlotte T1 - Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion JF - Clinical Pharmacokinetics N2 - Background Cytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter the exposure of CYP3A substrates. However, effects of such drug-drug interactions are usually reported as maximum effects rather than studied as time-dependent processes. Identification of the time course of CYP3A modulation can provide insight into when significant changes to CYP3A activity occurs, help better design drug-drug interaction studies, and manage drug-drug interactions in clinical practice. Objective We aimed to quantify the time course and extent of the in vivo modulation of different CYP3A perpetrator drugs on hepatic CYP3A activity and distinguish different modulatory mechanisms by their time of onset, using pharmacologically inactive intravenous microgram doses of the CYP3A-specific substrate midazolam, as a marker of CYP3A activity. Methods Twenty-four healthy individuals received an intravenous midazolam bolus followed by a continuous infusion for 10 or 36 h. Individuals were randomized into four arms: within each arm, two individuals served as a placebo control and, 2 h after start of the midazolam infusion, four individuals received the CYP3A perpetrator drug: voriconazole (inhibitor, orally or intravenously), rifampicin (inducer, orally), or efavirenz (activator, orally). After midazolam bolus administration, blood samples were taken every hour (rifampicin arm) or every 15 min (remaining study arms) until the end of midazolam infusion. A total of 1858 concentrations were equally divided between midazolam and its metabolite, 1'-hydroxymidazolam. A nonlinear mixed-effects population pharmacokinetic model of both compounds was developed using NONMEM (R). CYP3A activity modulation was quantified over time, as the relative change of midazolam clearance encountered by the perpetrator drug, compared to the corresponding clearance value in the placebo arm. Results Time course of CYP3A modulation and magnitude of maximum effect were identified for each perpetrator drug. While efavirenz CYP3A activation was relatively fast and short, reaching a maximum after approximately 2-3 h, the induction effect of rifampicin could only be observed after 22 h, with a maximum after approximately 28-30 h followed by a steep drop to almost baseline within 1-2 h. In contrast, the inhibitory impact of both oral and intravenous voriconazole was prolonged with a steady inhibition of CYP3A activity followed by a gradual increase in the inhibitory effect until the end of sampling at 8 h. Relative maximum clearance changes were +59.1%, +46.7%, -70.6%, and -61.1% for efavirenz, rifampicin, oral voriconazole, and intravenous voriconazole, respectively. Conclusions We could distinguish between different mechanisms of CYP3A modulation by the time of onset. Identification of the time at which clearance significantly changes, per perpetrator drug, can guide the design of an optimal sampling schedule for future drug-drug interaction studies. The impact of a short-term combination of different perpetrator drugs on the paradigm CYP3A substrate midazolam was characterized and can define combination intervals in which no relevant interaction is to be expected. Y1 - 2022 U6 - https://doi.org/10.1007/s40262-022-01175-6 SN - 0312-5963 SN - 1179-1926 VL - 61 IS - 11 SP - 1595 EP - 1607 PB - Springer CY - Northcote ER - TY - JOUR A1 - Kapernaum, Nadia A1 - Lange, Alyna A1 - Ebert, Max A1 - Grunwald, Marco A. A1 - Häge, Christian A1 - Marino, Sebastian A1 - Zens, Anna A1 - Taubert, Andreas A1 - Gießelmann, Frank A1 - Laschat, Sabine T1 - Current topics in ionic liquid crystals JF - ChemPlusChem N2 - Ionic liquid crystals (ILCs), that is, ionic liquids exhibiting mesomorphism, liquid crystalline phases, and anisotropic properties, have received intense attention in the past years. Among others, this is due to their special properties arising from the combination of properties stemming from ionic liquids and from liquid crystalline arrangements. Besides interesting fundamental aspects, ILCs have been claimed to have tremendous application potential that again arises from the combination of properties and architectures that are not accessible otherwise, or at least not accessible easily by other strategies. The current review highlights recent developments in ILC research, starting with some key fundamental aspects. Further subjects covered include the synthesis and variations of modern ILCs, including the specific tuning of their mesomorphic behavior. The review concludes with reflections on some applications that may be within reach for ILCs and finally highlights a few key challenges that must be overcome prior and during true commercialization of ILCs. KW - electrochemistry KW - ionic liquid crystals KW - mesogen mesophases KW - self-assembly KW - X-ray diffraction Y1 - 2021 U6 - https://doi.org/10.1002/cplu.202100397 SN - 2192-6506 VL - 87 IS - 1 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Sudibyo, Maria R. P. A1 - Eibl, Eva P. S. A1 - Hainzl, Sebastian A1 - Hersir, Gylfi Páll T1 - Eruption Forecasting of Strokkur Geyser, Iceland, Using Permutation Entropy JF - Journal of geophysical research : Solid earth N2 - A volcanic eruption is usually preceded by seismic precursors, but their interpretation and use for forecasting the eruption onset time remain a challenge. A part of the eruptive processes in open conduits of volcanoes may be similar to those encountered in geysers. Since geysers erupt more often, they are useful sites for testing new forecasting methods. We tested the application of Permutation Entropy (PE) as a robust method to assess the complexity in seismic recordings of the Strokkur geyser, Iceland. Strokkur features several minute-long eruptive cycles, enabling us to verify in 63 recorded cycles whether PE behaves consistently from one eruption to the next one. We performed synthetic tests to understand the effect of different parameter settings in the PE calculation. Our application to Strokkur shows a distinct, repeating PE pattern consistent with previously identified phases in the eruptive cycle. We find a systematic increase in PE within the last 15 s before the eruption, indicating that an eruption will occur. We quantified the predictive power of PE, showing that PE performs better than seismic signal strength or quiescence when it comes to forecasting eruptions. KW - permutation entropy KW - forecasting KW - geyser KW - eruption KW - hydrothermal system; KW - volcano-seismology Y1 - 2022 U6 - https://doi.org/10.1029/2022JB024840 SN - 2169-9313 SN - 2169-9356 VL - 127 IS - 10 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Wutzler, Bianca A1 - Hudson, Paul A1 - Thieken, Annegret T1 - Adaptation strategies of flood-damaged businesses in Germany JF - Frontiers in water N2 - Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication. KW - risk management KW - climate change adaptation KW - floods KW - disaster risk KW - reduction KW - Germany KW - precaution KW - emergency management Y1 - 2022 U6 - https://doi.org/10.3389/frwa.2022.932061 SN - 2624-9375 VL - 4 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Moldenhawer, Ted A1 - Moreno, Eduardo A1 - Schindler, Daniel A1 - Flemming, Sven A1 - Holschneider, Matthias A1 - Huisinga, Wilhelm A1 - Alonso, Sergio A1 - Beta, Carsten T1 - Spontaneous transitions between amoeboid and keratocyte-like modes of migration JF - Frontiers in Cell and Developmental Biology N2 - The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton. Despite the common force-generating actin machinery, different cell types often show diverse modes of locomotion that differ in their shape dynamics, speed, and persistence of motion. Recently, experiments in Dictyostelium discoideum have revealed that different motility modes can be induced in this model organism, depending on genetic modifications, developmental conditions, and synthetic changes of intracellular signaling. Here, we report experimental evidence that in a mutated D. discoideum cell line with increased Ras activity, switches between two distinct migratory modes, the amoeboid and fan-shaped type of locomotion, can even spontaneously occur within the same cell. We observed and characterized repeated and reversible switchings between the two modes of locomotion, suggesting that they are distinct behavioral traits that coexist within the same cell. We adapted an established phenomenological motility model that combines a reaction-diffusion system for the intracellular dynamics with a dynamic phase field to account for our experimental findings. KW - cell migration KW - amoeboid motility KW - keratocytle-like motility KW - modes of KW - migration KW - D. discoideum KW - actin dynamics Y1 - 2022 U6 - https://doi.org/10.3389/fcell.2022.898351 SN - 2296-634X VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Markov, Adrian A1 - Hauser, Lukas A1 - Chaabene, Helmi T1 - Effects of concurrent strength and endurance training on measures of physical fitness in healthy middle-aged and older adults BT - a systematic review with meta-analysis JF - Sports medicine : an international journal of applied medicine and science in sport and exercise N2 - Background There is evidence that in older adults the combination of strength training (ST) and endurance training (ET) (i.e., concurrent training [CT]) has similar effects on measures of muscle strength and cardiorespiratory endurance (CRE) compared with single-mode ST or ET, respectively. Therefore, CT seems to be an effective method to target broad aspects of physical fitness in older adults. Objectives The aim was to examine the effects of CT on measures of physical fitness (i.e., muscle strength, power, balance and CRE) in healthy middle-aged and older adults aged between 50 and 73 years. We also aimed to identify key moderating variables to guide training prescription. Study Design We conducted a systematic review with meta-analysis of randomized controlled trials. Data Sources The electronic databases PubMed, Web of Science Core Collection, MEDLINE and Google Scholar were systematically searched until February 2022. Eligibility Criteria for Selecting Studies We included randomized controlled trials that examined the effects of CT versus passive controls on measures of physical fitness in healthy middle-aged and older adults aged between 50 and 73 years. Results Fifteen studies were eligible, including a total of 566 participants. CT induced moderate positive effects on muscle strength (standardized mean difference [SMD] = 0.74) and power (SMD = 0.50), with a small effect on CRE (SMD = 0.48). However, no significant effects were detected for balance (p > 0.05). Older adults > 65 years (SMD = 1.04) and females (SMD = 1.05) displayed larger improvements in muscle strength compared with adults <= 65 years old (SMD = 0.60) and males (SMD = 0.38), respectively. For CRE, moderate positive effects (SMD = 0.52) were reported in those <= 65 years old only, with relatively larger gains in females (SMD = 0.55) compared with males (SMD = 0.45). However, no significant differences between all subgroups were detected. Independent single training factor analysis indicated larger positive effects of 12 weeks (SMD = 0.87 and 0.88) compared with 21 weeks (SMD = 0.47 and 0.29) of CT on muscle strength and power, respectively, while for CRE, 21 weeks of CT resulted in larger gains (SMD = 0.62) than 12 weeks (SMD = 0.40). For CT frequency, three sessions per week produced larger beneficial effects (SMD = 0.91) on muscle strength compared with four sessions (SMD = 0.55), whereas for CRE, moderate positive effects were only noted after four sessions per week (SMD = 0.58). A session duration of > 30-60 min generated larger improvements in muscle strength (SMD = 0.99) and power (SMD = 0.88) compared with > 60-90 min (SMD = 0.40 and 0.29, respectively). However, for CRE, longer session durations (i.e., > 60-90 min) seem to be more effective (SMD = 0.61) than shorter ones (i.e., > 30-60 min) (SMD = 0.34). ET at moderate-to-near maximal intensities produced moderate (SMD = 0.64) and small positive effects (SMD = 0.49) on muscle strength and CRE, respectively, with no effects at low intensity ET (p > 0.05). Finally, intra-session ST before ET produced larger gains in muscle strength (SMD = 1.00) compared with separate sessions (SMD = 0.55), whereas ET and ST carried out separately induced larger improvements in CRE (SMD = 0.58) compared with intra-session ET before ST (SMD = 0.49). Conclusions CT is an effective method to improve measures of physical fitness (i.e., muscle strength, power, and CRE) in healthy middle-aged and older adults aged between 50 and 73 years, regardless of sex. Results of independent single training factor analysis indicated that the largest effects on muscle strength were observed after 12 weeks of training, > 30-60 min per session, three sessions per week, higher ET intensities and when ST preceded ET within the same session. For CRE, the largest effects were noted after 21 weeks of training, four sessions per week, > 60-90 min per session, higher ET intensities and when ET and ST sessions were performed separately. Regarding muscle power, the largest effects were observed after 12 weeks of training and > 30-60 min per session. Y1 - 2022 U6 - https://doi.org/10.1007/s40279-022-01764-2 SN - 0112-1642 SN - 1179-2035 VL - 53 IS - 2 SP - 437 EP - 455 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Wright, Michelle F. A1 - Wachs, Sebastian T1 - Self-isolation practices and perceived social support from friends BT - the impact on adolescents' mental health JF - European journal of developmental psychology N2 - The purpose of the present study was to investigate the moderating effect of perceived social support from friends in the associations between self-isolation practices during the COVID-19 pandemic and adolescents' mental health (i.e., depression, subjective health complaints, self-harm), measured six months later (Time 2). Participants were 1,567 7(th) and 8(th) graders (51% female; 51% white; M age = 13.67) from the United States. They completed questionnaires on perceived social support from friends, depression, subjective health complaints, and self-harm at Time 1, and self-isolation practices during COVID-19, depression, subjective health complaints, and self-harm at Time 2. The findings revealed that self-isolation practices during COVID-19 was related positively to Time 1 perceived social support from friends, and negatively to Time 2 depression, subjective health complaints, and self-harm, while accounting for Time 1 mental health outcomes. Higher perceived social support from friends at Time 1 buffered against the negative impacts on adolescents' mental health outcomes at Time 2 when they practiced greater self-isolation during COVID-19, while lower perceived social support at Time 1 had the opposite effects on Time 2 mental health outcomes. KW - Friends KW - self-isolation KW - pandemic KW - mental health KW - depression KW - subjective KW - health complaints KW - self-harm Y1 - 2022 U6 - https://doi.org/10.1080/17405629.2022.2146090 SN - 1740-5629 SN - 1740-5610 VL - 20 IS - 4 SP - 635 EP - 648 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Westphal, Andrea A1 - Kalinowski, Eva A1 - Hoferichter, Clara Josepha A1 - Vock, Miriam T1 - K-12 teachers' stress and burnout during the COVID-19 pandemic BT - a systematic review JF - Frontiers in psychology N2 - We present the first systematic literature review on stress and burnout in K-12 teachers during the COVID-19 pandemic. Based on a systematic literature search, we identified 17 studies that included 9,874 K-12 teachers from around the world. These studies showed some indication that burnout did increase during the COVID-19 pandemic. There were, however, almost no differences in the levels of stress and burnout experienced by K-12 teachers compared to individuals employed in other occupational fields. School principals' leadership styles emerged as an organizational characteristic that is highly relevant for K-12 teachers' levels of stress and burnout. Individual teacher characteristics associated with burnout were K-12 teachers' personality, self-efficacy in online teaching, and perceived vulnerability to COVID-19. In order to reduce stress, there was an indication that stress-management training in combination with training in technology use for teaching may be superior to stress-management training alone. Future research needs to adopt more longitudinal designs and examine the interplay between individual and organizational characteristics in the development of teacher stress and burnout during the COVID-19 pandemic and beyond. KW - burnout KW - stress KW - COVID-19 KW - pandemic KW - K-12 teachers KW - remote teaching Y1 - 2022 U6 - https://doi.org/10.3389/fpsyg.2022.920326 SN - 1664-1078 VL - 13 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Bär, Christian A1 - Hanke, Bernhard T1 - Local flexibility for open partial differential relations JF - Communications on pure and applied mathematics / issued by the Courant Institute of Mathematical Sciences, New York Univ. N2 - We show that local deformations, near closed subsets, of solutions to open partial differential relations can be extended to global deformations, provided all but the highest derivatives stay constant along the subset. The applicability of this general result is illustrated by a number of examples, dealing with convex embeddings of hypersurfaces, differential forms, and lapse functions in Lorentzian geometry. The main application is a general approximation result by sections that have very restrictive local properties on open dense subsets. This shows, for instance, that given any K is an element of Double-struck capital R every manifold of dimension at least 2 carries a complete C-1,C- 1-metric which, on a dense open subset, is smooth with constant sectional curvature K. Of course, this is impossible for C-2-metrics in general. Y1 - 2021 U6 - https://doi.org/10.1002/cpa.21982 SN - 0010-3640 SN - 1097-0312 VL - 75 IS - 6 SP - 1377 EP - 1415 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Moreno, Eduardo A1 - Großmann, Robert A1 - Beta, Carsten A1 - Alonso, Sergio T1 - From single to collective motion of social amoebae BT - a computational study of interacting cells JF - Frontiers in physics N2 - The coupling of the internal mechanisms of cell polarization to cell shape deformations and subsequent cell crawling poses many interdisciplinary scientific challenges. Several mathematical approaches have been proposed to model the coupling of both processes, where one of the most successful methods relies on a phase field that encodes the morphology of the cell, together with the integration of partial differential equations that account for the polarization mechanism inside the cell domain as defined by the phase field. This approach has been previously employed to model the motion of single cells of the social amoeba Dictyostelium discoideum, a widely used model organism to study actin-driven motility and chemotaxis of eukaryotic cells. Besides single cell motility, Dictyostelium discoideum is also well-known for its collective behavior. Here, we extend the previously introduced model for single cell motility to describe the collective motion of large populations of interacting amoebae by including repulsive interactions between the cells. We performed numerical simulations of this model, first characterizing the motion of single cells in terms of their polarity and velocity vectors. We then systematically studied the collisions between two cells that provided the basic interaction scenarios also observed in larger ensembles of interacting amoebae. Finally, the relevance of the cell density was analyzed, revealing a systematic decrease of the motility with density, associated with the formation of transient cell clusters that emerge in this system even though our model does not include any attractive interactions between cells. This model is a prototypical active matter system for the investigation of the emergent collective dynamics of deformable, self-driven cells with a highly complex, nonlinear coupling of cell shape deformations, self-propulsion and repulsive cell-cell interactions. Understanding these self-organization processes of cells like their autonomous aggregation is of high relevance as collective amoeboid motility is part of wound healing, embryonic morphogenesis or pathological processes like the spreading of metastatic cancer cells. KW - cell motility KW - cell polarity KW - reaction-diffusion models KW - cell-cell KW - interactions KW - phase field model KW - collective motion KW - active matter Y1 - 2022 U6 - https://doi.org/10.3389/fphy.2021.750187 SN - 2296-424X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Kranjc Horvat, Anja A1 - Wiener, Jeff A1 - Schmeling, Sascha A1 - Borowski, Andreas T1 - Learning goals of professional development programs at science research institutions BT - a Delphi study with different stakeholder groups JF - Journal of science teacher education : the official journal of the Association for the Education of Teachers in Science N2 - Effective professional development programs (PDPs) rely on well-defined goals. However, recent studies on PDPs have not explored the goals from a multi-stakeholder perspective. This study identifies the most important learning goals of PDPs at science research institutions as perceived by four groups of stakeholders, namely teachers, education researchers, government representatives, and research scientists. Altogether, over 100 stakeholders from 42 countries involved in PDPs at science research institutions in Europe and North America participated in a three-round Delphi study. In the first round, the stakeholders provided their opinions on what they thought the learning goals of PDPs should be through an open-ended questionnaire. In the second and third rounds, the stakeholders assessed the importance of the learning goals that emerged from the first round by rating and ranking them, respectively. The outcome of the study is a hierarchical list of the ten most important learning goals of PDPs at particle physics laboratories. The stakeholders identified enhancing teachers' knowledge of scientific concepts and models and enhancing their knowledge of the curricula as the most important learning goals. Furthermore, the results show strong agreement between all the stakeholder groups regarding the defined learning goals. Indeed, all groups ranked the learning goals by their perceived importance almost identically. These outcomes could help policymakers establish more specific policies for PDPs. Additionally, they provide PDP practitioners at science research institutions with a solid base for future research and planning endeavors. KW - Teacher professional development KW - Delphi study KW - multi-stakeholder KW - analysis KW - pedagogical content knowledge Y1 - 2021 U6 - https://doi.org/10.1080/1046560X.2021.1905330 SN - 1046-560X SN - 1573-1847 VL - 33 IS - 1 SP - 32 EP - 54 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Fruhstorfer, Anna A1 - Hudson, Alexander T1 - Majorities for minorities BT - Participatory constitution making and the protection of minority rights JF - Political research quarterly : PRQ ; official journal of Western Political Science Association, Pacific Northwest Political Science Association, Southern California Political Science Association, Northern California Political Science Association N2 - Does the process of making a constitution affect the expansiveness of rights protections in the constitution? In particular, is more participation in constitution-making processes better for minority rights protections? While the process of constitution making and its impact on various outcomes have received significant attention, little is known about the impact public participation or deliberation in this process has on the scope and content of minority rights. Using a wide variety of data to empirically assess the relationship between constitution-making processes and the protection of rights for minorities, we find a positive relationship between participatory drafting processes and the inclusion of minority protections in constitutions under some conditions. The article's findings have important implications for understanding political representation and lend support to core arguments about the role of the public in constitutional design. KW - constitution-making KW - human rights KW - minority rights KW - direct democracy KW - public participation Y1 - 2022 U6 - https://doi.org/10.1177/1065912920984246 SN - 1065-9129 SN - 1938-274X VL - 75 IS - 1 SP - 103 EP - 117 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Mtilatila, Lucy Mphatso Ng'ombe A1 - Bronstert, Axel A1 - Vormoor, Klaus Josef T1 - Temporal evaluation and projections of meteorological droughts in the Greater Lake Malawi Basin, Southeast Africa JF - Frontiers in water N2 - The study examined the potential future changes of drought characteristics in the Greater Lake Malawi Basin in Southeast Africa. This region strongly depends on water resources to generate electricity and food. Future projections (considering both moderate and high emission scenarios) of temperature and precipitation from an ensemble of 16 bias-corrected climate model combinations were blended with a scenario-neutral response surface approach to analyses changes in: (i) the meteorological conditions, (ii) the meteorological water balance, and (iii) selected drought characteristics such as drought intensity, drought months, and drought events, which were derived from the Standardized Precipitation and Evapotranspiration Index. Changes were analyzed for a near-term (2021-2050) and far-term period (2071-2100) with reference to 1976-2005. The effect of bias-correction (i.e., empirical quantile mapping) on the ability of the climate model ensemble to reproduce observed drought characteristics as compared to raw climate projections was also investigated. Results suggest that the bias-correction improves the climate models in terms of reproducing temperature and precipitation statistics but not drought characteristics. Still, despite the differences in the internal structures and uncertainties that exist among the climate models, they all agree on an increase of meteorological droughts in the future in terms of higher drought intensity and longer events. Drought intensity is projected to increase between +25 and +50% during 2021-2050 and between +131 and +388% during 2071-2100. This translates into +3 to +5, and +7 to +8 more drought months per year during both periods, respectively. With longer lasting drought events, the number of drought events decreases. Projected droughts based on the high emission scenario are 1.7 times more severe than droughts based on the moderate scenario. That means that droughts in this region will likely become more severe in the coming decades. Despite the inherent high uncertainties of climate projections, the results provide a basis in planning and (water-)managing activities for climate change adaptation measures in Malawi. This is of particular relevance for water management issues referring hydro power generation and food production, both for rain-fed and irrigated agriculture. KW - meteorological drought KW - drought intensity KW - climate change KW - drought KW - events KW - Lake Malawi KW - Shire River KW - drought projections KW - South-Eastern KW - Africa Y1 - 2022 U6 - https://doi.org/10.3389/frwa.2022.1041452 SN - 2624-9375 VL - 4 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Aral, Tuğçe A1 - Schachner, Maja K. A1 - Juang, Linda P. A1 - Schwarzenthal, Miriam T1 - Cultural diversity approaches in schools and adolescents’ willingness to support refugee youth JF - British journal of educational psychology / British Psychological Society N2 - Background Culturally diverse schools contribute to adolescents' intergroup relations. Complex and inclusive social identities are mechanisms that can explain the link between structural school cultural diversity (i.e., proportion of students of immigrant descent and the number of different ethnic groups) and positive intergroup relations. We expected that similar mechanisms might be at play linking cultural diversity approaches in schools with adolescents' intergroup relations. Aim We examined the link between two sub-dimensions of cultural diversity approaches (i.e., equal treatment; heritage and intercultural learning) and adolescents' prosocial intentions and behaviour towards refugee youth. Then, we explored the mediating role of identity inclusiveness (i.e., perceived similarity of the self with others). Sample and methods We sampled culturally diverse eighth grade adolescents from 54 classrooms in Berlin (N = 503, M-age = 13.76 years, 50.6% female). Surveys measured perceived cultural diversity norms, adolescents' perceived identity inclusiveness with refugee youth, prosocial intentions to support refugee youth, and willingness to donate to a project for refugee youth. Results Multilevel models revealed that adolescents' perception of heritage and intercultural learning predicted adolescents' prosocial intentions towards refugee youth, but not their willingness to donate. Equal treatment was not a significant predictor of adolescents' prosocial intentions towards refugee youth, or their willingness to donate. Identity inclusiveness did not mediate the relation between cultural diversity approaches and prosocial intentions. However, identity inclusiveness did positively relate adolescents' prosocial intentions and willingness to donate. Conclusions We conclude that culturally diverse schools that engage in heritage and intercultural learning might help to promote positive relations between local and refugee youth in schools and society. Fostering inclusive identities may enhance local adolescent's prosocial intention and behaviour. KW - equal treatment KW - heritage and intercultural learning KW - prosocial KW - intentions KW - prosocial behaviour KW - identity inclusiveness KW - refugee youth Y1 - 2021 U6 - https://doi.org/10.1111/bjep.12458 SN - 0007-0998 SN - 2044-8279 VL - 92 IS - 2 SP - 772 EP - 799 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Spiekermann, Sarah A1 - Krasnova, Hanna A1 - Hinz, Oliver A1 - Baumann, Annika A1 - Benlian, Alexander A1 - Gimpel, Henner A1 - Heimbach, Irina A1 - Koester, Antonia A1 - Maedche, Alexander A1 - Niehaves, Bjoern A1 - Risius, Marten A1 - Trenz, Manuel T1 - Values and ethics in information systems BT - a state-of-the-art analysis and avenues for future research JF - Business & information systems engineering Y1 - 2022 U6 - https://doi.org/10.1007/s12599-021-00734-8 SN - 2363-7005 SN - 1867-0202 VL - 64 IS - 2 SP - 247 EP - 264 PB - Springer Gabler CY - Wiesbaden ER - TY - JOUR A1 - Krause, Hannes-Vincent A1 - Große Deters, Fenne A1 - Baumann, Annika A1 - Krasnova, Hanna T1 - Active social media use and its impact on well-being BT - an experimental study on the effects of posting pictures on Instagram JF - Journal of computer-mediated communication : a journal of the International Communication Association N2 - Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established hypothesis is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with considerable heterogeneity among existing studies on the hypothesis and causal evidence still limited, a final verdict on its robustness is still pending. To contribute to this ongoing debate, we conducted a week-long randomized control trial with N = 381 adult Instagram users recruited via Prolific. Specifically, we tested how active SNS use, operationalized as picture postings on Instagram, affects different dimensions of well-being. The results depicted a positive effect on users' positive affect but null findings for other well-being outcomes. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs.
Lay Summary Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established assumption is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with great diversity among conducted studies on the hypothesis and a lack of causal evidence, a final verdict on its viability is still pending. To contribute to this ongoing debate, we conducted a week-long experimental investigation with 381 adult Instagram users. Specifically, we tested how posting pictures on Instagram affects different aspects of well-being. The results of this study depicted a positive effect of posting Instagram pictures on users' experienced positive emotions but no effects on other aspects of well-being. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs on users. KW - social networking sites KW - social media KW - Instagram KW - well-being KW - experiment KW - randomized control trial Y1 - 2022 U6 - https://doi.org/10.1093/jcmc/zmac037 SN - 1083-6101 VL - 28 IS - 1 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Vinod, Deepak A1 - Cherstvy, Andrey G. A1 - Metzler, Ralf A1 - Sokolov, Igor M. T1 - Time-averaging and nonergodicity of reset geometric Brownian motion with drift JF - Physical review : E, Statistical, nonlinear and soft matter physics N2 - How do near-bankruptcy events in the past affect the dynamics of stock-market prices in the future? Specifically, what are the long-time properties of a time-local exponential growth of stock-market prices under the influence of stochastically occurring economic crashes? Here, we derive the ensemble- and time-averaged properties of the respective "economic" or geometric Brownian motion (GBM) with a nonzero drift exposed to a Poissonian constant-rate price-restarting process of "resetting." We examine-based both on thorough analytical calculations and on findings from systematic stochastic computer simulations-the general situation of reset GBM with a nonzero [positive] drift and for all special cases emerging for varying parameters of drift, volatility, and reset rate in the model. We derive and summarize all short- and long-time dependencies for the mean-squared displacement (MSD), the variance, and the mean time-averaged MSD (TAMSD) of the process of Poisson-reset GBM under the conditions of both rare and frequent resetting. We consider three main regions of model parameters and categorize the crossovers between different functional behaviors of the statistical quantifiers of this process. The analytical relations are fully supported by the results of computer simulations. In particular, we obtain that Poisson-reset GBM is a nonergodic stochastic process, with generally MSD(Delta) not equal TAMSD(Delta) and Variance(Delta) not equal TAMSD(Delta) at short lag times Delta and for long trajectory lengths T. We investigate the behavior of the ergodicity-breaking parameter in each of the three regions of parameters and examine its dependence on the rate of reset at Delta/T << 1. Applications of these theoretical results to the analysis of prices of reset-containing options are pertinent. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevE.106.034137 SN - 2470-0045 SN - 2470-0053 VL - 106 IS - 3 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Czakon, Wojciech A1 - Klimas, Patrycja A1 - Tiberius, Victor A1 - Ferreira, João A1 - Veiga, Pedro M. A1 - Kraus, Sascha T1 - Entrepreneurial failure BT - structuring a widely overlooked field of research JF - Entrepreneurship research journal N2 - Although entrepreneurial failure (EF) is a fairly recent topic in entrepreneurship literature, the number of publications has been growing dynamically and particularly rapidly. Our systematic review maps and integrates the research on EF based on a multi-method approach to give structure and consistency to this fragmented field of research. The results reveal that the field revolves around six thematic clusters of EF: 1) Soft underpinnings of EF, 2) Contextuality of EF, 3) Perception of EF, 4) Two-sided effects of EF, 5) Multi-stage EF effects, and 6) Institutional drivers of EF. An integrative framework of the positive and negative effects of entrepreneurial failure is proposed, and a research agenda is suggested. KW - entrepreneurial failure KW - entrepreneurship KW - failure outcomes KW - systematic review Y1 - 2022 U6 - https://doi.org/10.1515/erj-2021-0328 SN - 2157-5665 SP - 1 EP - 34 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Sandberg, Helene A1 - Alnoor, Alhamzah A1 - Tiberius, Victor T1 - Environmental, social, and governance ratings and financial performance BT - evidence from the European food industry JF - Business strategy and the environment N2 - Long-term value creation is expected not only to be concerned with maximizing shareholder value but also includes the impact on other stakeholders and the environment. Environmental, social, and governance (ESG) issues are therefore gaining increasing importance, in line with the growing demand for corporate sustainability. ESG ratings foster the comparison of companies with respect to their sustainable practices. This study aims to investigate how ESG ratings impact financial performance in the European food industry. Ordinary least squares regression is applied to analyze the relation between ESG ratings and financial performance over a 4-year period from 2017 to 2020. The profitability measures Return on Assets (ROA) and Return on Equity (ROE) are employed as financial performance measures, while ESG ratings are obtained from the database CSRHub. Results show that higher ESG ratings are associated with better financial performance. Although the effect is modest in the present study, the findings support previous results that ESG ratings are positively related to financial performance. Nonetheless, they also highlight that ESG ratings strongly converge to the mean, which depicts the need to reassess whether ESG ratings are able to measure actual ESG behavior. KW - ESG ratings KW - firm performance KW - food industry Y1 - 2022 U6 - https://doi.org/10.1002/bse.3259 SN - 0964-4733 SN - 1099-0836 VL - 32 IS - 4 SP - 2471 EP - 2489 PB - Wiley CY - New York ER - TY - JOUR A1 - Alerasoul, Sayed Alireza A1 - Tiberius, Victor A1 - Bouncken, Ricarda B. T1 - Entrepreneurship and innovation BT - the coevolution of two fields JF - Journal of small business strategy N2 - Both entrepreneurship and innovation play a key role for business growth and economic development and are conceptually highly intertwined. Both fields have received extensive attention that has resulted in a large number of publications. The aim of this work is to provide an overview on the coevolution of entrepreneurship and innovation over the last decades, with particular attention to recent research trends. To track the evolution at the intersection of both fields, we employ a bibliometric analysis, which allowed us to identify the key concepts, the backbone of research, and to provide a systematic classification of main research themes diagnosed including: 1) entrepreneurial innovation and digital transformation, 2) sustainable innovation and entrepreneurship, 3) product innovation and knowledge, 4) entrepreneurial orientation and leadership, and 5) regional entrepreneurship and innovation (innovative entrepreneurship and historical roots). The findings of this bibliometric review are reported in the form of a knowledge graph that represents the results obtained in terms of the knowledge base (key terms), knowledge domains, and knowledge evolution (themes and bursts), based on which themes for future research are suggested. KW - bibliometric analysis KW - literature review KW - innovation KW - entrepreneurship KW - knowledge graph Y1 - 2022 U6 - https://doi.org/10.53703/001c.29968 SN - 1081-8510 SN - 2380-1751 VL - 32 IS - 2 PB - Middle Tennessee State University CY - Murfreesboro, TN ER - TY - JOUR A1 - Fredrich, Viktor A1 - Bouncken, Ricarda B. A1 - Tiberius, Victor T1 - Dyadic business model convergence or divergence in alliances? BT - a configurational approach JF - Journal of business research N2 - In this study, we contribute to the scholarly conversation on firm-level business model changes following a neoconfigurational approach. By exploring configurations of business model changes over time, we add the direction of business model changes-namely business model convergence or divergence-as a vital avenue to the business model innovation literature. We identify necessary business model convergence and divergence recipes in a sample of N = 217 strategic dyadic alliances. Firstly, technological proximity emerges as a single precondition to both converging and diverging business models. Secondly, business models between competitors either converge through complementarities or tend not to change relative to each other. Thirdly, equity participation enables business model divergence through co-specialization. We conclude with a discussion of business model trajectories and future research directions. KW - Business model innovation KW - Business model changes KW - Convergence vs KW - divergence KW - Strategic alliances KW - Fuzzy -set qualitative comparative KW - analysis KW - (fsQCA) Y1 - 2022 U6 - https://doi.org/10.1016/j.jbusres.2022.08.046 SN - 0148-2963 SN - 1873-7978 VL - 153 SP - 300 EP - 308 PB - Elsevier CY - New York ER - TY - JOUR A1 - Gorupec, Natalia A1 - Brehmer, Nataliia A1 - Tiberius, Victor A1 - Kraus, Sascha T1 - Tackling uncertain future scenarios with real options BT - a review and research framework JF - The Irish journal of management N2 - Real options are widely applied in strategic and operational decision-making, allowing for managerial flexibility in uncertaincontexts. Increased scholarly interest has led to an extensive but fragmented research landscape. We aim to measure andsystematize the research field quantitatively. To achieve this goal, we conduct bibliometric performance analyses and bibliographiccoupling analyses with an in-depth content review. The results of the performance analyses show an increasing interest in realoptions since the beginning of the 2000s and identify the most influential journals and authors. The science mappings reveal sixand seven research clusters over the last two decades. Based on an in-depth analysis of their themes, we develop a researchframework comprising antecedents, application areas, internal and external contingencies, and uncertainty resolution throughreal option valuation or reasoning. We identify several gaps in that framework, which we propose to tackle in future research. KW - bibliometric analysis KW - decision processes KW - real options KW - research framework Y1 - 2022 U6 - https://doi.org/10.2478/ijm-2022-0003 SN - 2451-2834 VL - 41 IS - 1 SP - 69 EP - 88 PB - Sciendo CY - Warsaw ER - TY - JOUR A1 - Alnoor, Alhamzah A1 - Tiberius, Victor A1 - Atiyah, Abbas Gatea A1 - Khaw, Khai Wah A1 - Yin, Teh Sin A1 - Chew, XinYing A1 - Abbas, Sammar T1 - How positive and negative electronic word of mouth (eWOM) affects customers’ intention to use social commerce? BT - a dual-stage multi group-SEM and ANN analysis JF - International journal of human computer interaction N2 - Advances in Web 2.0 technologies have led to the widespread assimilation of electronic commerce platforms as an innovative shopping method and an alternative to traditional shopping. However, due to pro-technology bias, scholars focus more on adopting technology, and slightly less attention has been given to the impact of electronic word of mouth (eWOM) on customers’ intention to use social commerce. This study addresses the gap by examining the intention through exploring the effect of eWOM on males’ and females’ intentions and identifying the mediation of perceived crowding. To this end, we adopted a dual-stage multi-group structural equation modeling and artificial neural network (SEM-ANN) approach. We successfully extended the eWOM concept by integrating negative and positive factors and perceived crowding. The results reveal the causal and non-compensatory relationships between the constructs. The variables supported by the SEM analysis are adopted as the ANN model’s input neurons. According to the natural significance obtained from the ANN approach, males’ intentions to accept social commerce are related mainly to helping the company, followed by core functionalities. In contrast, females are highly influenced by technical aspects and mishandling. The ANN model predicts customers’ intentions to use social commerce with an accuracy of 97%. We discuss the theoretical and practical implications of increasing customers’ intention toward social commerce channels among consumers based on our findings. Y1 - 2022 U6 - https://doi.org/10.1080/10447318.2022.2125610 SN - 1044-7318 SN - 1532-7590 SP - 1 EP - 30 PB - Taylor & Francis CY - New York ER - TY - JOUR A1 - Fredrich, Viktor A1 - Bouncken, Ricarda B. A1 - Tiberius, Victor T1 - Dyadic business model convergence or divergence in alliances? BT - a configurational approach JF - Journal of business research N2 - In this study, we contribute to the scholarly conversation on firm-level business model changes following a neoconfigurational approach. By exploring configurations of business model changes over time, we add the direction of business model changes—namely business model convergence or divergence—as a vital avenue to the business model innovation literature. We identify necessary business model convergence and divergence recipes in a sample of N = 217 strategic dyadic alliances. Firstly, technological proximity emerges as a single pre-condition to both converging and diverging business models. Secondly, business models between competitors either converge through complementarities or tend not to change relative to each other. Thirdly, equity participation enables business model divergence through co-specialization. We conclude with a discussion of business model trajectories and future research directions. Y1 - 2022 U6 - https://doi.org/10.1016/j.jbusres.2022.08.046 SN - 0148-2963 VL - 153 SP - 300 EP - 308 PB - Elsevier CY - New York ER - TY - JOUR A1 - Bouncken, Ricarda B. A1 - Ratzmann, Martin A1 - Tiberius, Victor A1 - Brem, Alexander T1 - Pioneering strategy in supply chain relationships BT - how coercive power and contract completeness influence innovation JF - IEEE transactions on engineering management N2 - Today, firms pursuing a pioneering strategy are often engaged in supply chain relationships to benefit from external resources and to improve their innovation. However, this effort can be impeded by power asymmetries in such relationships and especially by the execution of coercive power by their partner firm. Contracts could potentially reduce this risk of opportunistic behavior. Our survey study on 778 small to medium-sized enterprises in the European packaging and medical equipment industries examines how coercive power of the partner and the contractual arrangement between firms moderate the pioneering strategy's innovation outcomes in the short and long run. Our results confirm the negative effect of coercive power on innovation performance in both the short and long term. However, the compensating effect of rather complete contracts differs temporally. Whereas, contract completeness protects against higher dependence at the beginning of the collaboration, their effect diminishes over time. In contrast, rather incomplete contracts enhance the innovation performance in the long term, possibly complemented with trust. KW - alliances KW - coercive power KW - contracts KW - pioneering strategy KW - R&D KW - supply chain Y1 - 2020 U6 - https://doi.org/10.1109/TEM.2020.3019965 SN - 0018-9391 VL - 69 IS - 6 SP - 2826 EP - 2841 PB - IEEE CY - New York ER - TY - JOUR A1 - Deyanova, Kameliya A1 - Brehmer, Nataliia A1 - Lapidus, Artur A1 - Tiberius, Victor A1 - Walsh, Steve T1 - Hatching start-ups for sustainable growth BT - A bibliometric review on business incubators JF - Review of managerial science N2 - Business incubators hatch start-ups, helping them to survive their early stage and to create a solid foundation for sustainable growth by providing services and access to knowledge. The great practical relevance led to a strong interest of researchers and a high output of scholarly publications, which made the field complex and scattered. To organize the research on incubators and provide a systematic overview of the field, we conducted bibliometric performance analyses and science mappings. The performance analyses depict the temporal development of the number of incubator publications and their citations, the most cited and most productive journals, countries, and authors, and the 20 most cited articles. The author keyword co-occurrence analysis distinguishes six, and the bibliographic coupling seven research themes. Based on a content analysis of the science mappings, we propose a research framework for future research on business incubators. KW - business incubators KW - bibliometric analysis KW - nascent entrepreneurs KW - start-ups Y1 - 2022 U6 - https://doi.org/10.1007/s11846-022-00525-9 SN - 1863-6683 SN - 1863-6691 VL - 16 IS - 7 SP - 2083 EP - 2109 PB - Springer CY - Berlin ER - TY - JOUR A1 - Khaw, Khai Wah A1 - Alnoor, Alhamzah A1 - Al-Abrrow, Hadi A1 - Tiberius, Victor A1 - Ganesan, Yuvaraj A1 - Atshan, Nadia A. T1 - Reactions towards organizational change BT - a systematic literature review JF - Current psychology N2 - Regardless of the prevalence and value of change initiatives in contemporary organizations, these often face resistance by employees. This resistance is the outcome of change recipients’ cognitive and behavioral reactions towards change. To better understand the causes and effects of reactions to change, a holistic view of prior research is needed. Accordingly, we provide a systematic literature review on this topic. We categorize extant research into four major and several subcategories: micro and macro reactions. We analyze the essential characteristics of the emerging field of change reactions along research issues and challenges, benefits of (even negative) reactions, managerial implications, and propose future research opportunities. KW - reactions to organizational change KW - research framework KW - research issues KW - systematic literature review Y1 - 2022 U6 - https://doi.org/10.1007/s12144-022-03070-6 SN - 1046-1310 SN - 1936-4733 SP - 1 EP - 24 PB - Springer CY - New York ER - TY - JOUR A1 - Seckler, Henrik A1 - Metzler, Ralf T1 - Bayesian deep learning for error estimation in the analysis of anomalous diffusion JF - Nature Communications N2 - Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms encoded in the data and thus to better understand the probed systems. We here augment recently proposed machine-learning techniques for decoding anomalous-diffusion data to include an uncertainty estimate in addition to the predicted output. To avoid the Black-Box-Problem a Bayesian-Deep-Learning technique named Stochastic-Weight-Averaging-Gaussian is used to train models for both the classification of the diffusion model and the regression of the anomalous diffusion exponent of single-particle-trajectories. Evaluating their performance, we find that these models can achieve a well-calibrated error estimate while maintaining high prediction accuracies. In the analysis of the output uncertainty predictions we relate these to properties of the underlying diffusion models, thus providing insights into the learning process of the machine and the relevance of the output.
Diffusive motions in complex environments such as living biological cells or soft matter systems can be analyzed with single-particle-tracking approaches, where accuracy of output may vary. The authors involve a machine-learning technique for decoding anomalous-diffusion data and provide an uncertainty estimate together with predicted output. Y1 - 2022 U6 - https://doi.org/10.1038/s41467-022-34305-6 SN - 2041-1723 VL - 13 IS - 1 PB - Nature portfolio CY - Berlin ER - TY - JOUR A1 - Fischer, Caroline A1 - Siegel, John A1 - Proeller, Isabella A1 - Drathschmidt, Nicolas T1 - Resilience through digitalisation BT - How individual and organisational resources affect public employees working from home during the COVID-19 pandemic JF - Public management review N2 - This article examines public service resilience during the COVID-19 pandemic and studies the switch to telework due to social distancing measures. We argue that the pandemic and related policies led to increasing demands on public organisations and their employees. Following the job demands-resources model, we argue that resilience only can arise in the presence of resources for buffering these demands. Survey data were collected from 1,189 German public employees, 380 participants were included for analysis. The results suggest that the public service was resilient against the crisis and that the shift to telework was not as demanding as expected. KW - resilience KW - digitalisation KW - innovation KW - telework KW - work-place behavior KW - capacity KW - job demands-resources model KW - multi-level study Y1 - 2022 U6 - https://doi.org/10.1080/14719037.2022.2037014 SN - 1471-9037 SN - 1471-9045 VL - 25 IS - 4 SP - 808 EP - 835 PB - Routledge, Taylor & Francis CY - London ER - TY - JOUR A1 - Burek, Wojciech T1 - Reservations to the Istanbul Convention and the role of GREVIO: A call for new approach JF - Human rights law review N2 - The question of whether the monitoring bodies have competence concerning reservations is at the centre of the discussion of reservations to human rights treaties that has occupied many international legal scholars over the last few decades. The Istanbul Convention’s treaty monitoring body, GREVIO, is the only human rights treaty monitoring body with a direct competence concerning reservations. However, as practice to date shows, it does not make much use of this power. This is a big disappointment considering all the efforts of other bodies in the past and the doctrinal positions of various scholars. The main aims of this article are threefold to: present GREVIO’s practice to date concerning reservations, provide a brief historical overview of how other human rights treaty bodies have approached their role concerning reservations, and finally, attempt to explain why GREVIO has abandoned a more proactive position on reservations. KW - reservations to human rights treaties KW - interpretative declarations KW - Istanbul Convention KW - GREVIO KW - human rights treaty monitoring bodies Y1 - 2022 U6 - https://doi.org/10.1093/hrlr/ngac030 SN - 1461-7781 SN - 1744-1021 VL - 22 IS - 4 SP - 1 EP - 18 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Kearney, Eric A1 - Razinskas, Stefan A1 - Weiss, Matthias A1 - Hoegl, Martin T1 - Gender diversity and team performance under time pressure BT - the role of team withdrawal and information elaboration JF - Journal of organizational behavior N2 - Findings in the extant literature are mixed concerning when and how gender diversity benefits team performance. We develop and test a model that posits that gender-diverse teams outperform gender-homogeneous teams when perceived time pressure is low, whereas the opposite is the case when perceived time pressure is high. Drawing on the categorization-elaboration model (CEM; van Knippenberg, De Dreu, & Homan, 2004), we begin with the assumption that information elaboration is the process whereby gender diversity fosters positive effects on team performance. However, also in line with the CEM, we argue that this process can be disrupted by adverse team dynamics. Specifically, we argue that as time pressure increases, higher gender diversity leads to more team withdrawal, which, in turn, moderates the positive indirect effect of gender diversity on team performance via information elaboration such that this effect becomes weaker as team withdrawal increases. In an experimental study of 142 four-person teams, we found support for this model that explains why perceived time pressure affects the performance of gender-diverse teams more negatively than that of gender-homogeneous teams. Our study sheds new light on when and how gender diversity can become either an asset or a liability for team performance. KW - gender diversity KW - information elaboration KW - perceived time pressure KW - team KW - performance KW - team withdrawal Y1 - 2022 U6 - https://doi.org/10.1002/job.2630 SN - 0894-3796 SN - 1099-1379 VL - 43 IS - 7 SP - 1224 EP - 1239 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Haggenmüller, Sandra A1 - Oehlschläger, Patricia A1 - Herbst, Uta A1 - Voeth, Markus T1 - Time for change? BT - scenario analysis on buyer–seller negotiations JF - The journal of business & industrial marketing N2 - Purpose: This study aims to provide probable future developments in the form of holistic scenarios for business negotiations. In recent years, negotiation research did not put a lot of emphasis on external changes. Consequently, current challenges and trends are scarcely integrated, making it difficult to support negotiation practice perspectively. Design/methodology/approach: This paper applies the structured, multi-method approach of scenario analysis. To examine the future space of negotiations, this combines qualitative and quantitative measures to base our analysis on negotiation experts’ assessments, estimations and visions of the negotiation future. Findings: The results comprise an overview of five negotiation scenarios in the year 2030 and of their individual drivers. The five revealed scenarios are: digital intelligence, business as usual, powerful network – the route to collaboration, powerful network – the route to predominance and system crash. Originality/value: The scenario analysis is a suitable approach that enables to relate various factors of the negotiation environment to negotiations themselves and allows an examination of future changes in buyer–seller negotiations and the creation of possible future scenarios. The identified scenarios provide an orientation for business decisions in the field of negotiation. KW - Negotiating KW - Scenario analysis KW - COVID-19 KW - Business negotiation KW - Buyer–seller negotiations KW - Future scenarios Y1 - 2022 U6 - https://doi.org/10.1108/JBIM-11-2021-0511 SN - 0885-8624 SN - 2052-1189 VL - 38 IS - 5 SP - 1215 EP - 1242 PB - Emerald Publishing Limited CY - Bingley ER - TY - JOUR A1 - Sparr, Jennifer L. A1 - van Knippenberg, Daan A1 - Kearney, Eric T1 - Paradoxical leadership as sensegiving BT - stimulating change-readiness and change-oriented performance JF - Leadership & organization development journal N2 - Purpose Paradoxical leadership (PL) is an emerging perspective to understand how leaders help followers deal with paradoxical demands. Recently, the positive relationship between PL and follower performance was established. This paper builds on and extends this research by interpreting PL as sensegiving and developing theory about mediation in the relationship between PL and adaptive and proactive performance. Design/methodology/approach The paper develops a new measure for PL as sensegiving and provides a test of the mediation model with data from two different sources and two measurement times in a German company. Findings Multilevel mediation analysis (N = 154) supports the mediation model. Originality/value The paper presents sensegiving about paradox as a core element of PL, which informs the choice of change-readiness as mediator. This study also develops and validates a scale to measure PL in future research. KW - Paradoxical leadership KW - Sensegiving KW - Change-readiness KW - Adaptive KW - performance KW - Proactive performance Y1 - 2022 U6 - https://doi.org/10.1108/LODJ-04-2021-0161 SN - 0143-7739 SN - 1472-5347 VL - 43 IS - 2 SP - 225 EP - 237 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Hartlieb, Matthias T1 - Photo-iniferter RAFT polymerization JF - Macromolecular rapid communications : publishing the newsletters of the European Polymer Federation N2 - Light-mediated polymerization techniques offer distinct advantages over polymerization reactions fueled by thermal energy, such as high spatial and temporal control as well as the possibility to work under mild reaction conditions. Reversible addition-fragmentation chain-transfer (RAFT) polymerization is a highly versatile radical polymerization method that can be utilized to control a variety of monomers and produce a vast number of complex macromolecular structures. The use of light to drive a RAFT-polymerization is possible via multiple routes. Besides the use of photo-initiators, or photo-catalysts, the direct activation of the chain transfer agent controlling the RAFT process in a photo-iniferter (PI) process is an elegant way to initiate and control polymerization reactions. Within this review, PI-RAFT polymerization and its advantages over the conventional RAFT process are discussed in detail. KW - light KW - photo-iniferter reversible addition-fragmentation chain-transfer KW - photo-mediated polymerization KW - radical polymerization KW - reversible KW - addition-fragmentation chain-transfer polymerization Y1 - 2021 U6 - https://doi.org/10.1002/marc.202100514 SN - 1521-3927 VL - 43 IS - 1 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Maier, Corinna Sabrina A1 - Wiljes, Jana de A1 - Hartung, Niklas A1 - Kloft, Charlotte A1 - Huisinga, Wilhelm T1 - A continued learning approach for model-informed precision dosing BT - Updating models in clinical practice JF - CPT: pharmacometrics & systems pharmacology N2 - Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use. Y1 - 2021 U6 - https://doi.org/10.1002/psp4.12745 SN - 2163-8306 VL - 11 IS - 2 SP - 185 EP - 198 PB - London CY - Nature Publ. Group ER - TY - JOUR A1 - Bosch, David A1 - Smimou, Kamal T1 - Traders’ motivation and hedging pressure in commodity futures markets JF - Research in international business and finance N2 - This study seeks to explain the major drivers of trading activity in commodity futures markets and gage the effect of trading activity on commodity prices. Rather than concentrating on a specific commodity subgroup or a particular type of commodity traders, we provide an extensive overview of the behavior across all market participants and their influence on commodity prices by using a broad set of commodity futures contracts. Although commodity futures returns show co-movement with financial fundamentals (U.S. dollar index, equity, and bond markets), based on the Disaggregated Commitment of Traders Report (DCOT), this relationship cannot be attributed to trading activity. Pricing in commodity markets can be predominantly attributed to hedgers and influential speculators (money managers), whereas small speculators (nonreportable traders) are crucial to some soft commodity futures similar to dealers in metals commodity futures. Furthermore, we find limited cases where inventory changes exert a sizable influence on position changes of DCOT traders. KW - Hedgers KW - Speculators KW - Motivation KW - Interaction KW - Futures prices KW - Commodity KW - markets Y1 - 2021 U6 - https://doi.org/10.1016/j.ribaf.2021.101529 SN - 0275-5319 SN - 1878-3384 VL - 59 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bünning, Mareike A1 - Hipp, Lena T1 - How can we become more equal? BT - public policies and parents’ work–family preferences in Germany JF - Journal of European social policy N2 - This study examines how public policies affect parents' preferences for a more egalitarian division of paid and unpaid work. Based on the assumption that individuals develop their preferences within a specific policy context, we examine how changes in three policies affect mothers' and fathers' work-family preferences: the availability of high-quality, affordable childcare; the right to return to a full-time job after having reduced hours to part-time and an increase in the number of 'partner months' in parental leave schemes. Analysing a unique probability sample of parents with young children in Germany from 2015 (N = 1756), we find that fathers would want to work slightly fewer hours if they had the right to return to a full-time position after working part-time, and mothers would want to work slightly more hours if childcare opportunities were improved. Full-time working parents, moreover, are found to prefer fewer hours independent of the policy setting, while non-employed parents would like to work at least some hours. Last but not least, our analyses show that increasing the number of partner months in the parental leave scheme considerably increases fathers' preferences for longer and mothers' preferences for shorter leave. Increasing the number of partner months in parental schemes hence has the greatest potential to increase gender equality. KW - work-family policies KW - parental leave KW - childcare KW - working time KW - regulations KW - parenthood KW - working hours KW - gender equality KW - preferences KW - capabilities framework Y1 - 2021 U6 - https://doi.org/10.1177/09589287211035701 SN - 0958-9287 SN - 1461-7269 VL - 32 IS - 2 SP - 182 EP - 196 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Zimmermann, Andreas A1 - Schabedoth, John Alexander T1 - Domestic and international criminal justice BT - challenges ahead JF - KFG working paper series N2 - This paper consists of two parts: In the first part, some of the challenges with which the Internationaal Criminal Court is currently confronted are being presented. First of all, the article will describe the current state of the International Criminal Court and the Rome Statue. Afterwards, the article analyses the Court’s efforts to deal with cases against third-country nationals and the challenges it is facing in that regard. In addition, the Court’s case law will be analyzed in order to determine an increasing ‘emancipation’ of the case law of the International Criminal Court from international humanitarian law. The second part of the paper will briefly discuss the role of domestic international criminal law and domestic courts in the further development and enforcement of international criminal law. As an example of the role that domestic courts may have in clarifying classic issues in international law, the judgment of the German Supreme Court of January 28, 2021 (3 StR 564/19), which deals with the status of costumary international law on functional immunity of State officials before domestic courts, shall be assessed. Y1 - 2022 U6 - https://doi.org/10.2139/ssrn.4087189 SN - 2509-3762 SN - 2509-3770 IS - 57 PB - Berlin Potsdam Research Group International Law - Rise or Decline? CY - Berlin ER - TY - JOUR A1 - Jacobs, Ingo A1 - Wollny, Anna Irena T1 - Personal values, trait emotional intelligence, and mental health problems JF - Scandinavian journal of psychology N2 - Personal values and personality traits are related yet distinguishable constructs linked to mental health. The present study extends the current literature on personal values and personality traits by investigating the associations between the higher-order dimensions of personal values (i.e., general values factor, conservation, and self-transcendence), trait emotional intelligence (TEI), and mental health problems (i.e., depressive, anxiety, and somatoform syndromes). The study draws on a cross-sectional online sample of N = 618 young German adults. Global TEI and all four TEI factors (i.e., well-being, sociability, emotionality, and self-control) correlated positively with the g-value factor but negatively with conservation. Emotionality was also positively related to self-transcendence. Mental health problems correlated positively with conservation and negatively with the general values factor. When the effects of global TEI were accounted for, conservation but not the general values factor remained significantly related to mental health problems. Global TEI fully mediated the relationship between the g-value factor and mental health problems and partially mediated the association between conservation and mental health problems. The implications of these results are discussed. KW - General factor of values KW - mental health KW - personal values KW - trait KW - emotional intelligence KW - value circle Y1 - 2021 U6 - https://doi.org/10.1111/sjop.12785 SN - 0036-5564 SN - 1467-9450 VL - 63 IS - 2 SP - 155 EP - 163 PB - Wiley-Blackwell CY - Oxford ER -