TY - JOUR A1 - Ehrlich, Elias A1 - Thygesen, Uffe Høgsbro A1 - Kiørboe, Thomas T1 - Evolution of toxins as a public good in phytoplankton JF - Proceedings of the Royal Society of London : B, Biological sciences N2 - Toxic phytoplankton blooms have increased in many waterbodies worldwide with well-known negative impacts on human health, fisheries and ecosystems. However, why and how phytoplankton evolved toxin production is still a puzzling question, given that the producer that pays the costs often shares the benefit with other competing algae and thus provides toxins as a 'public good' (e.g. damaging a common competitor or predator). Furthermore, blooming phytoplankton species often show a high intraspecific variation in toxicity and we lack an understanding of what drives the dynamics of coexisting toxic and non-toxic genotypes. Here, by using an individual-based two-dimensional model, we show that small-scale patchiness of phytoplankton strains caused by demography can explain toxin evolution in phytoplankton with low motility and the maintenance of genetic diversity within their blooms. This patchiness vanishes for phytoplankton with high diffusive motility, suggesting different evolutionary pathways for different phytoplankton groups. In conclusion, our study reveals that small-scale spatial heterogeneity, generated by cell division and counteracted by diffusive cell motility and turbulence, can crucially affect toxin evolution and eco-evolutionary dynamics in toxic phytoplankton species. This contributes to a better understanding of conditions favouring toxin production and the evolution of public goods in asexually reproducing organisms in general. KW - toxic algal blooms KW - evolution of cooperation KW - coexistence KW - patchiness in KW - phytoplankton KW - eco-evolutionary feedback KW - spatial pattern formation Y1 - 2022 U6 - https://doi.org/10.1098/rspb.2022.0393 SN - 0962-8452 SN - 1471-2954 VL - 289 IS - 1977 PB - Royal Society CY - London ER - TY - JOUR A1 - Neuharth, Derek A1 - Brune, Sascha A1 - Wrona, Thilo A1 - Glerum, Anne A1 - Braun, Jean A1 - Yuan, Xiaoping T1 - Evolution of rift systems and their fault networks in response to surface processes JF - Tectonics N2 - Continental rifting is responsible for the generation of major sedimentary basins, both during rift inception and during the formation of rifted continental margins. Geophysical and field studies revealed that rifts feature complex networks of normal faults but the factors controlling fault network properties and their evolution are still matter of debate. Here, we employ high-resolution 2D geodynamic models (ASPECT) including two-way coupling to a surface processes (SP) code (FastScape) to conduct 12 models of major rift types that are exposed to various degrees of erosion and sedimentation. We further present a novel quantitative fault analysis toolbox (Fatbox), which allows us to isolate fault growth patterns, the number of faults, and their length and displacement throughout rift history. Our analysis reveals that rift fault networks may evolve through five major phases: (a) distributed deformation and coalescence, (b) fault system growth, (c) fault system decline and basinward localization, (d) rift migration, and (e) breakup. These phases can be correlated to distinct rifted margin domains. Models of asymmetric rifting suggest rift migration is facilitated through both ductile and brittle deformation within a weak exhumation channel that rotates subhorizontally and remains active at low angles. In sedimentation-starved settings, this channel satisfies the conditions for serpentinization. We find that SP are not only able to enhance strain localization and to increase fault longevity but that they also reduce the total length of the fault system, prolong rift phases and delay continental breakup. KW - rifts KW - fault network KW - surface processes KW - geodynamics Y1 - 2022 U6 - https://doi.org/10.1029/2021TC007166 SN - 0278-7407 SN - 1944-9194 VL - 41 IS - 3 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Toumoulin, Agathe A1 - Tardif-Becquet, Delphine A1 - Donnadieu, Yannick A1 - Licht, Alexis A1 - Ladant, Jean-Baptiste A1 - Kunzmann, Lutz A1 - Dupont-Nivet, Guillaume T1 - Evolution of continental temperature seasonality from the Eocene greenhouse to the Oligocene icehouse BT - a model-data comparison JF - Climate of the past : an interactive open access journal of the European Geosciences Union N2 - At the junction of greenhouse and icehouse climate states, the Eocene-Oligocene Transition (EOT) is a key moment in Cenozoic climate history. While it is associated with severe extinctions and biodiversity turnovers on land, the role of terrestrial climate evolution remains poorly resolved, especially the associated changes in seasonality. Some paleobotanical and geochemical continental records in parts of the Northern Hemisphere suggest the EOT is associated with a marked cooling in winter, leading to the development of more pronounced seasons (i.e., an increase in the mean annual range of temperature, MATR). However, the MATR increase has been barely studied by climate models and large uncertainties remain on its origin, geographical extent and impact. In order to better understand and describe temperature seasonality changes between the middle Eocene and the early Oligocene, we use the Earth system model IPSL-CM5A2 and a set of simulations reconstructing the EOT through three major climate forcings: pCO(2) decrease (1120, 840 and 560 ppm), the Antarctic ice-sheet (AIS) formation and the associated sea-level decrease. Our simulations suggest that pCO(2) lowering alone is not sufficient to explain the seasonality evolution described by the data through the EOT but rather that the combined effects of pCO(2) , AIS formation and increased continentality provide the best data-model agreement.pCO(2) decrease induces a zonal pattern with alternating increasing and decreasing seasonality bands particularly strong in the northern high latitudes (up to 8 degrees C MATR increase) due to sea-ice and surface albedo feedback. Conversely, the onset of the AIS is responsible for a more constant surface albedo yearly, which leads to a strong decrease in seasonality in the southern midlatitudes to high latitudes (> 40 degrees S). Finally, continental areas that emerged due to the sea-level lowering cause the largest increase in seasonality and explain most of the global heterogeneity in MATR changes (1MATR) patterns. The Delta MATR patterns we reconstruct are generally consistent with the variability of the EOT biotic crisis intensity across the Northern Hemisphere and provide insights on their underlying mechanisms. Y1 - 2022 U6 - https://doi.org/10.5194/cp-18-341-2022 SN - 1814-9324 SN - 1814-9332 VL - 18 IS - 2 SP - 341 EP - 362 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Schifferle, Lukas A1 - Lobanov, Sergey S. T1 - Evolution of chemical bonding and spin-pairing energy in ferropericlase across Its spin transition JF - ACS Earth and Space Chemistry N2 - The evolution of chemical bonding in ferropericlase, (Mg,Fe)O, with pressure may affect the physical and chemical properties of the Earth's lower mantle. Here, we report high-pressure optical absorption spectra of single-crystalline ferropericlase ((Mg0.87Fe0.13)O) up to 135 GPa. Combined with a re-evaluation of published partial fluorescence yield X-ray absorption spectroscopy data, we show that the covalency of the Fe-O bond increases with pressure, but the iron spin transition at 57-76.5 GPa reverses this trend. The qualitative crossover in chemical bonding suggests that the spin-pairing transition weakens the Fe-O bond in ferropericlase. We find, that the spin transition in ferropericlase is caused by both the increase of the ligand field-splitting energy and the decrease in the spin-pairing energy of high-spin Fe2+. KW - high-pressure KW - diamond anvil cell KW - covalency KW - bond strength KW - iron KW - spin KW - transition Y1 - 2022 U6 - https://doi.org/10.1021/acsearthspacechem.2c00014 SN - 2472-3452 VL - 6 IS - 3 SP - 788 EP - 799 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Niemeyer, Helen A1 - Lorbeer, Noemi A1 - Mohr, Jil A1 - Baer, Ella A1 - Knaevelsrud, Christine T1 - Evidence-based individual psychotherapy for complex posttraumatic stress disorder and at-risk groups for complex traumatization BT - a meta-review JF - Journal of affective disorders : an official publication of the International Society for Affective Disorders, ISAD N2 - Background: The current meta-review of meta-analyses on psychotherapy research for complex post-traumatic stress disorder (CPTSD) and samples at risk of complex traumatization has three aims: first, to provide an overview of efficacy of individual psychotherapies; second, to compare the quality of the meta-analyses; and third, to assess statistical power. Methods: The literature search was conducted until August 2020. Meta-analyses providing individual treatment effect estimates focusing on CPTSD or samples at risk of complex traumatization (i.e., victims of childhood sexual abuse (CSA), war or torture, refugees, and veterans with PTSD) were eligible for inclusion. The effect sizes were classified according to Cohen as small, medium, or large. The "A MeaSurement Tool to Assess systematic Reviews" (AMSTAR) was applied to assess the quality of the meta-analyses, and power was assessed post-hoc. Results: Twenty-four meta-analyses were suitable for inclusion. The efficacy of the interventions varied (g = -0.04 (CI -0.39; 0.48), controlled, to d = 2.73 (1.69; 3.76), uncontrolled). Overall, 16 effect estimates were large. On average, the quality of the meta-analyses was good (average AMSTAR total score 7.71 points (range 3-11). Considering quality assessments and power together, nine meta-analyses were evaluated as high quality. Limitations: No meta-analysis for CPTSD was eligible and the number of individuals with complex traumatization was not directly assessed in the at-risk groups. Conclusions: For at-risk groups for complex traumatization, on average, good-quality empirical evidence exists. Given the limited research on CPTSD, future studies are needed to further investigate the efficacy of interventions. KW - Meta -review KW - Meta -analysis KW - Complex posttraumatic stress disorder KW - Complex traumatization KW - Psychotherapy Y1 - 2022 U6 - https://doi.org/10.1016/j.jad.2021.12.056 SN - 0165-0327 SN - 1573-2517 VL - 299 SP - 610 EP - 619 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hermanussen, Michael A1 - Scheffler, Christiane T1 - Evidence of chronic undernutrition in late 19th century German infants of all social classes JF - Human biology and public health N2 - 125 years ago, European infants grew differently from modern infants. We show weight gains of 20 healthy children weighed longitudinally from birth to age 1 year, published by Camerer in 1882. The data illustrate the historically prevalent concepts of infant nutrition practiced by German civil servants, lawyers, merchants, university professors, physicians, foresters and farmers. Breastfeeding by the mother was not truly appreciated in those days; children were often breastfed by wet nurses or received bottled milk. Bottle feeding mainly used diluted cow’s milk with some added carbohydrates, without evidence that appropriate amounts of oil, butter or other fatty components were added. French children from 1914 showed similar weight gain patterns suggesting similar feeding practices. The historical data suggest that energy deficient infant formula was fed regularly in the late 19th and early 20th century Europe, regardless of wealth and social class. The data question current concerns that temporarily feeding energy deficient infant formula may warrant serious anxieties regarding long-term cognitive, social and emotional behavioral development. KW - chronic undernutrition KW - breastfeeding KW - historical growth KW - social class KW - translation Y1 - 2022 U6 - https://doi.org/10.52905/hbph2022.2.42 SN - 2748-9957 VL - 2022 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Giraudier, Manon A1 - Ventura-Bort, Carlos A1 - Burger, Andreas M. A1 - Claes, Nathalie A1 - D'Agostini, Martina A1 - Fischer, Rico A1 - Franssen, Mathijs A1 - Kaess, Michael A1 - Koenig, Julian A1 - Liepelt, Roman A1 - Nieuwenhuis, Sander A1 - Sommer, Aldo A1 - Usichenko, Taras A1 - Van Diest, Ilse A1 - von Leupoldt, Andreas A1 - Warren, Christopher Michael A1 - Weymar, Mathias T1 - Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis JF - Brain Stimulation N2 - Background Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. Methods The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. Results While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. Conclusion(s) Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research. KW - Non-invasive vagus nerve stimulation KW - tVNS KW - sAA KW - Noradrenaline KW - Biomarker KW - Data pooling Y1 - 2022 U6 - https://doi.org/10.1016/j.brs.2022.09.009 SN - 1876-4754 VL - 15 SP - 1378 EP - 1388 PB - Elsevier CY - New York, NY, USA ET - 6 ER - TY - JOUR A1 - Macdonald, Elena A1 - Merz, Bruno A1 - Guse, Björn A1 - Wietzke, Luzie A1 - Ullrich, Sophie A1 - Kemter, Matthias A1 - Ahrens, Bodo A1 - Vorogushyn, Sergiy T1 - Event and catchment controls of heavy tail behavior of floods JF - Water resources research N2 - In some catchments, the distribution of annual maximum streamflow shows heavy tail behavior, meaning the occurrence probability of extreme events is higher than if the upper tail decayed exponentially. Neglecting heavy tail behavior can lead to an underestimation of the likelihood of extreme floods and the associated risk. Partly contradictory results regarding the controls of heavy tail behavior exist in the literature and the knowledge is still very dispersed and limited. To better understand the drivers, we analyze the upper tail behavior and its controls for 480 catchments in Germany and Austria over a period of more than 50 years. The catchments span from quickly reacting mountain catchments to large lowland catchments, allowing for general conclusions. We compile a wide range of event and catchment characteristics and investigate their association with an indicator of the tail heaviness of flood distributions, namely the shape parameter of the GEV distribution. Following univariate analyses of these characteristics, along with an evaluation of different aggregations of event characteristics, multiple linear regression models, as well as random forests, are constructed. A novel slope indicator, which represents the relation between the return period of flood peaks and event characteristics, captures the controls of heavy tails best. Variables describing the catchment response are found to dominate the heavy tail behavior, followed by event precipitation, flood seasonality, and catchment size. The pre-event moisture state in a catchment has no relevant impact on the tail heaviness even though it does influence flood magnitudes. KW - heavy tail behavior KW - floods KW - event characteristics KW - catchment KW - characteristics KW - catchment response Y1 - 2022 U6 - https://doi.org/10.1029/2021WR031260 SN - 0043-1397 SN - 1944-7973 VL - 58 IS - 6 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Yadav, Anshul A1 - Sen, Sumit A1 - Mao, Luca A1 - Schwanghart, Wolfgang T1 - Evaluation of flow resistance equations for high gradient rivers using geometric standard deviation of bed material JF - Journal of hydrology N2 - A dataset of 2184 field measurements reported in the literature was used to evaluate the predictive capability of eight conventional flow resistance equations to predict the mean flow velocity in gravel-bed rivers. The results reveal considerable disagreement with the observed flow velocities for relative submergence less than 4 and for the non-uniformity of the bed material greater than 7.5 for all the equations. However, the predictions made using the Smart and Jaggi (1983), Ferguson (2007), and Rickenmann and Recking (2011) equations were closer to the observed values. Furthermore, bedload sediment transport also reduces the predictive capability of the equations considered in this study except for the Recking et al. (2008) equation, which was developed consid- ering active bedload transport. The performance of flow resistance equations improves when corrected by considering the geometric standard deviation of the bed material. Here we present an empirical approach using the whole dataset and its subsets for accounting for the additional energy losses occurring due to the wake vortices, spill losses, and free surface instabilities occurring due to the protrusions from the bed. The results obtained using the validation dataset shows the importance and usefulness of this approach to account for the additional energy losses, especially for the Strickler (1923) and Keulegan (1938) equations. KW - Flow resistance KW - Relative submergence KW - Non-uniformity KW - Microtopography KW - Bedload sediment transport Y1 - 2022 U6 - https://doi.org/10.1016/j.jhydrol.2021.127292 SN - 0022-1694 SN - 1879-2707 VL - 605 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Weinelt, Ferdinand Anton A1 - Stegemann, Miriam Songa A1 - Theloe, Anja A1 - Pfäfflin, Frieder A1 - Achterberg, Stephan A1 - Weber, Franz A1 - Dübel, Lucas A1 - Mikolajewska, Agata A1 - Uhrig, Alexander A1 - Kiessling, Peggy A1 - Huisinga, Wilhelm A1 - Michelet, Robin A1 - Hennig, Stefanie A1 - Kloft, Charlotte T1 - Evaluation of a meropenem and piperacillin monitoring program in intensive care unit patients calls for the regular assessment of empirical targets and easy-to-use dosing decision tools JF - Antibiotics : open access journal N2 - The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets. To reliably achieve the targeted concentrations, dosing needs to be adjusted for renal function. We aimed to evaluate a meropenem and piperacillin/tazobactam monitoring program in intensive care unit (ICU) patients by assessing (i) the adequacy of locally selected empirical targets, (ii) if dosing is adequately adjusted for renal function and individual target, and (iii) if dosing is adjusted in target attainment (TA) failure. In a prospective, observational clinical trial of drug concentrations, relevant patient characteristics and microbiological data (pathogen, minimum inhibitory concentration (MIC)) for patients receiving meropenem or piperacillin/tazobactam treatment were collected. If the MIC value was available, a target range of 1-5 x MIC was selected for minimum drug concentrations of both drugs. If the MIC value was not available, 8-40 mg/L and 16-80 mg/L were selected as empirical target ranges for meropenem and piperacillin, respectively. A total of 356 meropenem and 216 piperacillin samples were collected from 108 and 96 ICU patients, respectively. The vast majority of observed MIC values was lower than the empirical target (meropenem: 90.0%, piperacillin: 93.9%), suggesting empirical target value reductions. TA was found to be low (meropenem: 35.7%, piperacillin 50.5%) with the lowest TA for severely impaired renal function (meropenem: 13.9%, piperacillin: 29.2%), and observed drug concentrations did not significantly differ between patients with different targets, indicating dosing was not adequately adjusted for renal function or target. Dosing adjustments were rare for both drugs (meropenem: 6.13%, piperacillin: 4.78%) and for meropenem irrespective of TA, revealing that concentration monitoring alone was insufficient to guide dosing adjustment. Empirical targets should regularly be assessed and adjusted based on local susceptibility data. To improve TA, scientific knowledge should be translated into easy-to-use dosing strategies guiding antibiotic dosing. KW - meropenem KW - piperacillin/tazobactam KW - antimicrobial stewardship KW - critically ill KW - antibiotics KW - pharmacokinetic/pharmacodynamic Y1 - 2022 U6 - https://doi.org/10.3390/antibiotics11060758 SN - 2079-6382 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kunyu, David Khisoni A1 - Juang, Linda P. A1 - Moreno Herrera, Lázaro T1 - Evaluating the implementation quality of a vocational education intervention for youth in Dadaab refugee camp in Kenya BT - Evidence of discrimination JF - Frontiers in human dynamics N2 - Refugee youth in protracted humanitarian contexts are faced with limited access to quality education. They may sustain traumatic experiences from conflicts and discrimination yet have limited psychosocial support access. Comprehending the magnitude and effects of these challenges is vital for designing and executing educational interventions in such contexts. This study evaluates the implementation quality of the Youth Education Pack intervention through the lens of the Inter-agency Network for Education in Emergencies minimum standards framework. It explores the types of discrimination experienced by refugee youth in the Dadaab refugee camp in Kenya. Nine participants comprising refugee students (N = 2), former refugee students (N = 2), teachers (N = 3), and project supervisors (N = 2) participated in the study. The first author conducted interviews and observations in the camp. The data were qualitatively coded deductively and analysed in Nvivo 12. We found that the YEP intervention faced contextual challenges that hindered the achievement of the implementation quality standards outlined in the INEE minimum standards for education. Refugee youth and refugee teachers experienced various forms of discrimination, including at individual, institutional, and structural levels. We conclude that providing refugee youth with an inclusive and high-quality education is central to providing secure and long-term solutions to their challenges and adversities and may promote their psychosocial wellbeing. KW - refugee youth KW - Education in Emergencies KW - implementation quality KW - discrimination KW - the YEP intervention KW - the INEE minimum standards Y1 - 2022 U6 - https://doi.org/10.3389/fhumd.2022.898081 SN - 2673-2726 VL - 4 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Kiang, Lisa A1 - Stein, Gabriela L. A1 - Juang, Linda P. T1 - Ethnic and racial identity of immigrants and effects on mental health JF - Current Opinion in Psychology N2 - Robust research continues to broaden and deepen the field's understanding of immigrants' ethnic-racial identity and mental health. We highlight opportunities to pioneer the literature by questioning "who" is meant by immigrant (clearly defining generational status, going beyond covariate and difference -based approaches, focusing on immigrants from under-studied ethnic-racial backgrounds), "what" is meant by iden-tity (ethnic/heritage/native, conjoined with multiple identities such as national, regional, politicized), "where" experiences are taking place (globalization, differences in how immigrants are defined and viewed across contexts), and the "why" or importance of continuing this work (identity as resilience against mental health risks). Targeting under-researched in-tersections among the "who-what-where-why" can build knowledge and insight for researchers and practitioners who work with immigrant families, and perhaps for immigrants themselves. KW - ethnic-racial identity KW - mental health KW - immigrants KW - context Y1 - 2022 U6 - https://doi.org/10.1016/j.copsyc.2022.101424 SN - 2352-250X SN - 2352-2518 VL - 47 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wetzel, Anna-Jasmin A1 - Koch, Roland A1 - Preiser, Christine A1 - Müller, Regina A1 - Klemmt, Malte A1 - Ranisch, Robert A1 - Ehni, Hans-Jörg A1 - Wiesing, Urban A1 - Rieger, Monika A. A1 - Henking, Tanja A1 - Joos, Stefanie T1 - Ethical, legal, and social implications of symptom checker Apps in primary Health Care (CHECK.APP) BT - protocol for an interdisciplinary mixed methods study JF - JMIR Research Protocols N2 - Background: Symptom checker apps (SCAs) are accessible tools that provide early symptom assessment for users. The ethical, legal, and social implications of SCAs and their impact on the patient-physician relationship, the health care providers, and the health care system have sparsely been examined. This study protocol describes an approach to investigate the possible impacts and implications of SCAs on different levels of health care provision. It considers the perspectives of the users, nonusers, general practitioners (GPs), and health care experts. Objective: We aim to assess a comprehensive overview of the use of SCAs and address problematic issues, if any. The primary outcomes of this study are empirically informed multi-perspective recommendations for different stakeholders on the ethical, legal, and social implications of SCAs. Methods: Quantitative and qualitative methods will be used in several overlapping and interconnected study phases. In study phase 1, a comprehensive literature review will be conducted to assess the ethical, legal, social, and systemic impacts of SCAs. Study phase 2 comprises a survey that will be analyzed with a logistic regression. It aims to assess the user degree of SCAs in Germany as well as the predictors for SCA usage. Study phase 3 will investigate self-observational diaries and user interviews, which will be analyzed as integrated cases to assess user perspectives, usage pattern, and arising problems. Study phase 4 will comprise GP interviews to assess their experiences, perspectives, self-image, and concepts and will be analyzed with the basic procedure by Kruse. Moreover, interviews with health care experts will be conducted in study phase 3 and will be analyzed by using the reflexive thematical analysis approach of Braun and Clark. Results: Study phase 1 will be completed in November 2021. We expect the results of study phase 2 in December 2021 and February 2022. In study phase 3, interviews are currently being conducted. The final study endpoint will be in February 2023. Conclusions: The possible ethical, legal, social, and systemic impacts of a widespread use of SCAs that affect stakeholders and stakeholder groups on different levels of health care will be identified. The proposed methodological approach provides a multifaceted and diverse empirical basis for a broad discussion on these implications. KW - symptom checker apps KW - self-diagnosis KW - self-triage KW - digitalization in KW - primary care KW - general practitioners KW - symptom checker KW - app KW - mobile app; Y1 - 2022 U6 - https://doi.org/10.2196/34026 SN - 1929-0748 VL - 11 IS - 5 PB - JMIR Research Protocols CY - Toronto ER - TY - JOUR A1 - Paape, Dario A1 - Vasishth, Shravan T1 - Estimating the true cost of garden pathing: BT - a computational model of latent cognitive processes JF - Cognitive science N2 - What is the processing cost of being garden-pathed by a temporary syntactic ambiguity? We argue that comparing average reading times in garden-path versus non-garden-path sentences is not enough to answer this question. Trial-level contaminants such as inattention, the fact that garden pathing may occur non-deterministically in the ambiguous condition, and "triage" (rejecting the sentence without reanalysis; Fodor & Inoue, 2000) lead to systematic underestimates of the true cost of garden pathing. Furthermore, the "pure" garden-path effect due to encountering an unexpected word needs to be separated from the additional cost of syntactic reanalysis. To get more realistic estimates for the individual processing costs of garden pathing and syntactic reanalysis, we implement a novel computational model that includes trial-level contaminants as probabilistically occurring latent cognitive processes. The model shows a good predictive fit to existing reading time and judgment data. Furthermore, the latent-process approach captures differences between noun phrase/zero complement (NP/Z) garden-path sentences and semantically biased reduced relative clause (RRC) garden-path sentences: The NP/Z garden path occurs nearly deterministically but can be mostly eliminated by adding a comma. By contrast, the RRC garden path occurs with a lower probability, but disambiguation via semantic plausibility is not always effective. KW - garden-path effect KW - syntactic reanalysis KW - multinomial processing tree KW - latent processes KW - mixture modeling Y1 - 2022 U6 - https://doi.org/10.1111/cogs.13186 SN - 0364-0213 SN - 1551-6709 VL - 46 IS - 8 PB - Wiley-Blackwell CY - Malden, Mass. ER - TY - JOUR A1 - Ghafarian, Fatemeh A1 - Wieland, Ralf A1 - Nendel, Claas T1 - Estimating the Evaporative Cooling Effect of Irrigation within and above Soybean Canopy JF - Water N2 - Vegetation with an adequate supply of water might contribute to cooling the land surface around it through the latent heat flux of transpiration. This study investigates the potential estimation of evaporative cooling at plot scale, using soybean as example. Some of the plants' physiological parameters were monitored and sampled at weekly intervals. A physics-based model was then applied to estimate the irrigation-induced cooling effect within and above the canopy during the middle and late season of the soybean growth period. We then examined the results of the temperature changes at a temporal resolution of ten minutes between every two irrigation rounds. During the middle and late season of growth, the cooling effects caused by evapotranspiration within and above the canopy were, on average, 4.4 K and 2.9 K, respectively. We used quality indicators such as R-squared (R-2) and mean absolute error (MAE) to evaluate the performance of the model simulation. The performance of the model in this study was better above the canopy (R-2 = 0.98, MAE = 0.3 K) than below (R-2 = 0.87, MAE = 0.9 K) due to the predefined thermodynamic condition used to estimate evaporative cooling. Moreover, the study revealed that canopy cooling contributes to mitigating heat stress conditions during the middle and late seasons of crop growth. KW - canopy cooling effects KW - shading cooling KW - canopy-air temperature KW - energy KW - balance KW - the Penman-Monteith equation Y1 - 2022 U6 - https://doi.org/10.3390/w14030319 SN - 2073-4441 VL - 14 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wang, Chaoxuan A1 - Enssle, Jörg A1 - Pietzner, Anne A1 - Schmöcker, Christoph A1 - Weiland, Linda A1 - Ritter, Oliver A1 - Jaensch, Monique A1 - Elbelt, Ulf A1 - Pagonas, Nikolaos A1 - Weylandt, Karsten-Henrich T1 - Essential polyunsaturated fatty acids in blood from patients with and without catheter-proven coronary artery disease JF - International journal of molecular sciences N2 - Coronary artery disease (CAD) is the leading cause of death worldwide. Statins reduce morbidity and mortality of CAD. Intake of n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic acid (EPA), is associated with reduced morbidity and mortality in patients with CAD. Previous data indicate that a higher conversion of precursor fatty acids (FAs) to arachidonic acid (AA) is associated with increased CAD prevalence. Our study explored the FA composition in blood to assess n-3 PUFA levels from patients with and without CAD. We analyzed blood samples from 273 patients undergoing cardiac catheterization. Patients were stratified according to clinically relevant CAD (n = 192) and those without (n = 81). FA analysis in full blood was performed by gas chromatography. Indicating increased formation of AA from precursors, the ratio of dihomo-gamma-linolenic acid (DGLA) to AA, the delta-5 desaturase index (D5D index) was higher in CAD patients. CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6 PUFA) and n-3 PUFA, particularly EPA, in the blood. Thus, our study supports a role of increased EPA levels for cardioprotection. KW - coronary artery disease KW - triglycerides KW - polyunsaturated fatty acids KW - n-3 PUFA KW - statins KW - arachidonic acid Y1 - 2022 U6 - https://doi.org/10.3390/ijms23020766 SN - 1422-0067 SN - 1661-6596 VL - 23 IS - 2 PB - Molecular Diversity Preservation International CY - Basel ER - TY - JOUR A1 - Sudibyo, Maria R. P. A1 - Eibl, Eva P. S. A1 - Hainzl, Sebastian A1 - Hersir, Gylfi Páll T1 - Eruption Forecasting of Strokkur Geyser, Iceland, Using Permutation Entropy JF - Journal of geophysical research : Solid earth N2 - A volcanic eruption is usually preceded by seismic precursors, but their interpretation and use for forecasting the eruption onset time remain a challenge. A part of the eruptive processes in open conduits of volcanoes may be similar to those encountered in geysers. Since geysers erupt more often, they are useful sites for testing new forecasting methods. We tested the application of Permutation Entropy (PE) as a robust method to assess the complexity in seismic recordings of the Strokkur geyser, Iceland. Strokkur features several minute-long eruptive cycles, enabling us to verify in 63 recorded cycles whether PE behaves consistently from one eruption to the next one. We performed synthetic tests to understand the effect of different parameter settings in the PE calculation. Our application to Strokkur shows a distinct, repeating PE pattern consistent with previously identified phases in the eruptive cycle. We find a systematic increase in PE within the last 15 s before the eruption, indicating that an eruption will occur. We quantified the predictive power of PE, showing that PE performs better than seismic signal strength or quiescence when it comes to forecasting eruptions. KW - permutation entropy KW - forecasting KW - geyser KW - eruption KW - hydrothermal system; KW - volcano-seismology Y1 - 2022 U6 - https://doi.org/10.1029/2022JB024840 SN - 2169-9313 SN - 2169-9356 VL - 127 IS - 10 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Conrad, Markus A1 - Ullrich, Susann A1 - Schmidtke, David S. A1 - Kotz, Sonja A. T1 - ERPs reveal an iconic relation between sublexical phonology and affective meaning JF - Cognition : international journal of cognitive science N2 - Classical linguistic theory assumes that formal aspects, like sound, are not internally related to the meaning of words. However, recent research suggests language might code affective meaning such as threat and alert sublexically. Positing affective phonological iconicity as a systematic organization principle of the German lexicon, we calculated sublexical affective values for sub-syllabic phonological word segments from a large-scale affective lexical German database by averaging valence and arousal ratings of all words any phonological segment appears in. We tested word stimuli with either consistent or inconsistent mappings between lexical affective meaning and sublexical affective values (negative-valence/high-arousal vs. neutral-valence/lowarousal) in an EEG visual-lexical-decision task. A mismatch between sublexical and lexical affective values elicited an increased N400 response. These results reveal that systematic affective phonological iconicity - extracted from the lexicon - impacts the extraction of lexical word meaning during reading. KW - Sound symbolism KW - Visual word recognition KW - Phonological iconicity KW - Affective meaning KW - N400 KW - ERPs Y1 - 2022 U6 - https://doi.org/10.1016/j.cognition.2022.105182 SN - 0010-0277 SN - 1873-7838 VL - 226 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Fujihara, Kenji M. A1 - Zhang, Bonnie Z. A1 - Jackson, Thomas D. A1 - Ogunkola, Moses A1 - Nijagal, Brunda A1 - Milne, Julia V. A1 - Sallman, David A. A1 - Ang, Ching-Seng A1 - Nikolic, Iva A1 - Kearney, Conor J. A1 - Hogg, Simon J. A1 - Cabalag, Carlos S. A1 - Sutton, Vivien R. A1 - Watt, Sally A1 - Fujihara, Asuka T. A1 - Trapani, Joseph A. A1 - Simpson, Kaylene J. A1 - Stojanovski, Diana A1 - Leimkühler, Silke A1 - Haupt, Sue A1 - Phillips, Wayne A. A1 - Clemons, Nicholas J. T1 - Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction JF - Science Advances N2 - The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, al-though the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator. Using unbiased approaches, this study demonstrates that eprenetapopt depletes cellular antioxidant glutathione levels by increasing its turnover, triggering a nonapoptotic, iron-dependent form of cell death known as ferroptosis. Deficiency in genes responsible for supplying cancer cells with the substrates for de novo glutathione synthesis (SLC7A11, SHMT2, and MTHFD1L), as well as the enzymes required to synthesize glutathione (GCLC and GCLM), augments the activity of eprenetapopt. Eprenetapopt also inhibits iron-sulfur cluster biogenesis by limit-ing the cysteine desulfurase activity of NFS1, which potentiates ferroptosis and may restrict cellular proliferation. The combination of eprenetapopt with dietary serine and glycine restriction synergizes to inhibit esophageal xenograft tumor growth. These findings reframe the canonical view of eprenetapopt from a mutant-p53 reactivator to a ferroptosis inducer. Y1 - 2022 U6 - https://doi.org/10.1126/sciadv.abm9427 SN - 2375-2548 VL - 8 IS - 37 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Gomez-Zapata, Juan Camilo A1 - Pittore, Massimiliano A1 - Cotton, Fabrice A1 - Lilienkamp, Henning A1 - Shinde, Simantini A1 - Aguirre, Paula A1 - Santa Maria, Hernan T1 - Epistemic uncertainty of probabilistic building exposure compositions in scenario-based earthquake loss models JF - Bulletin of Earthquake Engineering N2 - In seismic risk assessment, the sources of uncertainty associated with building exposure modelling have not received as much attention as other components related to hazard and vulnerability. Conventional practices such as assuming absolute portfolio compositions (i.e., proportions per building class) from expert-based assumptions over aggregated data crudely disregard the contribution of uncertainty of the exposure upon earthquake loss models. In this work, we introduce the concept that the degree of knowledge of a building stock can be described within a Bayesian probabilistic approach that integrates both expert-based prior distributions and data collection on individual buildings. We investigate the impact of the epistemic uncertainty in the portfolio composition on scenario-based earthquake loss models through an exposure-oriented logic tree arrangement based on synthetic building portfolios. For illustrative purposes, we consider the residential building stock of Valparaiso (Chile) subjected to seismic ground-shaking from one subduction earthquake. We have found that building class reconnaissance, either from prior assumptions by desktop studies with aggregated data (top-down approach), or from building-by-building data collection (bottom-up approach), plays a fundamental role in the statistical modelling of exposure. To model the vulnerability of such a heterogeneous building stock, we require that their associated set of structural fragility functions handle multiple spectral periods. Thereby, we also discuss the relevance and specific uncertainty upon generating either uncorrelated or spatially cross-correlated ground motion fields within this framework. We successively show how various epistemic uncertainties embedded within these probabilistic exposure models are differently propagated throughout the computed direct financial losses. This work calls for further efforts to redesign desktop exposure studies, while also highlighting the importance of exposure data collection with standardized and iterative approaches. KW - Epistemic uncertainty KW - Sensitivity analysis KW - Scheme KW - Faceted taxonomy KW - Probabilistic exposure modelling KW - Earthquake scenario KW - Data collection KW - Earthquake loss modelling KW - Spatially cross-correlated ground motion KW - fields Y1 - 2022 U6 - https://doi.org/10.1007/s10518-021-01312-9 SN - 1570-761X SN - 1573-1456 N1 - Update notice Correction to: Epistemic uncertainty of probabilistic building exposure compositions in scenario-based earthquake loss models (Bulletin of Earthquake Engineering, (2022), 20, 5, (2401-2438), https://doi.org/10.1007/s10518-021-01312-9) Bulletin of Earthquake Engineering, Volume 20, Issue 5, Pages 2439, March 2022, https://doi.org/10.1007/s10518-022-01340-z VL - 20 IS - 5 SP - 2401 EP - 2438 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Perrella, Giorgio A1 - Bäurle, Isabel A1 - van Zanten, Martijn T1 - Epigenetic regulation of thermomorphogenesis and heat stress tolerance JF - New phytologist : international journal of plant science N2 - Many environmental conditions fluctuate and organisms need to respond effectively. This is especially true for temperature cues that can change in minutes to seasons and often follow a diurnal rhythm. Plants cannot migrate and most cannot regulate their temperature. Therefore, a broad array of responses have evolved to deal with temperature cues from freezing to heat stress. A particular response to mildly elevated temperatures is called thermomorphogenesis, a suite of morphological adaptations that includes thermonasty, formation of thin leaves and elongation growth of petioles and hypocotyl. Thermomorphogenesis allows for optimal performance in suboptimal temperature conditions by enhancing the cooling capacity. When temperatures rise further, heat stress tolerance mechanisms can be induced that enable the plant to survive the stressful temperature, which typically comprises cellular protection mechanisms and memory thereof. Induction of thermomorphogenesis, heat stress tolerance and stress memory depend on gene expression regulation, governed by diverse epigenetic processes. In this Tansley review we update on the current knowledge of epigenetic regulation of heat stress tolerance and elevated temperature signalling and response, with a focus on thermomorphogenesis regulation and heat stress memory. In particular we highlight the emerging role of H3K4 methylation marks in diverse temperature signalling pathways. KW - chromatin remodelling KW - elevated temperature KW - epigenetics KW - heat stress KW - histone modification KW - memory KW - temperature response KW - thermomorphogenesis Y1 - 2022 U6 - https://doi.org/10.1111/nph.17970 SN - 0028-646X SN - 1469-8137 VL - 234 IS - 4 SP - 1144 EP - 1160 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Sandberg, Helene A1 - Alnoor, Alhamzah A1 - Tiberius, Victor T1 - Environmental, social, and governance ratings and financial performance BT - evidence from the European food industry JF - Business strategy and the environment N2 - Long-term value creation is expected not only to be concerned with maximizing shareholder value but also includes the impact on other stakeholders and the environment. Environmental, social, and governance (ESG) issues are therefore gaining increasing importance, in line with the growing demand for corporate sustainability. ESG ratings foster the comparison of companies with respect to their sustainable practices. This study aims to investigate how ESG ratings impact financial performance in the European food industry. Ordinary least squares regression is applied to analyze the relation between ESG ratings and financial performance over a 4-year period from 2017 to 2020. The profitability measures Return on Assets (ROA) and Return on Equity (ROE) are employed as financial performance measures, while ESG ratings are obtained from the database CSRHub. Results show that higher ESG ratings are associated with better financial performance. Although the effect is modest in the present study, the findings support previous results that ESG ratings are positively related to financial performance. Nonetheless, they also highlight that ESG ratings strongly converge to the mean, which depicts the need to reassess whether ESG ratings are able to measure actual ESG behavior. KW - ESG ratings KW - firm performance KW - food industry Y1 - 2022 U6 - https://doi.org/10.1002/bse.3259 SN - 0964-4733 SN - 1099-0836 VL - 32 IS - 4 SP - 2471 EP - 2489 PB - Wiley CY - New York ER - TY - JOUR A1 - Kolbe, Benedikt Maximilian A1 - Evans, Myfanwy E. T1 - Enumerating isotopy classes of tilings guided by the symmetry of triply JF - Siam journal on applied algebra and geometry N2 - We present a technique for the enumeration of all isotopically distinct ways of tiling a hyperbolic surface of finite genus, possibly nonorientable and with punctures and boundary. This generalizes the enumeration using Delaney--Dress combinatorial tiling theory of combinatorial classes of tilings to isotopy classes of tilings. To accomplish this, we derive an action of the mapping class group of the orbifold associated to the symmetry group of a tiling on the set of tilings. We explicitly give descriptions and presentations of semipure mapping class groups and of tilings as decorations on orbifolds. We apply this enumerative result to generate an array of isotopically distinct tilings of the hyperbolic plane with symmetries generated by rotations that are commensurate with the threedimensional symmetries of the primitive, diamond, and gyroid triply periodic minimal surfaces, which have relevance to a variety of physical systems. KW - isotopic tiling theory KW - mapping class group KW - orbifolds KW - group KW - presentations KW - representations of groups as automorphism groups of KW - algebraic systems KW - triply periodic minimal surface KW - Delaney--Dress KW - tiling theory KW - hyperbolic tilings KW - two-dimensional topology Y1 - 2022 U6 - https://doi.org/10.1137/20M1358943 SN - 2470-6566 VL - 6 IS - 1 SP - 1 EP - 40 PB - Society for Industrial and Applied Mathematics CY - Philadelphia ER - TY - JOUR A1 - Tiberius, Victor A1 - Weyland, Michael T1 - Entrepreneurship education or entrepreneurship education? BT - a bibliometric analysis JF - Journal of further and higher education N2 - Entrepreneurship education (EE) has attracted much scholarly attention, showing exponential growth in publication and citation numbers. The research field has become broad, complex, and fragmented, making it increasingly difficult to oversee. Our research goal is to organise and integrate the previous literature. To this end, we use bibliometric analyses, differing from prior analyses, which are outdated or have a different focus. Our results show an immense growth in publications and citations over the last decade and an almost equal involvement of business and educational research. We identify the most productive and influential journals and authors. Our co-citation analysis reveals two research clusters, one focusing on psychological constructs relating to EE, and the other on entrepreneurial behaviour and new venture creation. Based on a review of the 25 most-cited articles on an annual basis, we identify and quantify the most relevant research themes and integrate them into a research framework that we propose for future research. A major finding is that extant research centres around the outcomes of entrepreneurship education, whereas its pedagogy is still mainly a black box. KW - Bibliometric analysis KW - co-citation analysis KW - education; KW - entrepreneurship KW - entrepreneurship education KW - performance analysis Y1 - 2022 U6 - https://doi.org/10.1080/0309877X.2022.2100692 SN - 0309-877X SN - 1469-9486 VL - 47 IS - 1 SP - 134 EP - 149 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Alerasoul, Sayed Alireza A1 - Tiberius, Victor A1 - Bouncken, Ricarda B. T1 - Entrepreneurship and innovation BT - the coevolution of two fields JF - Journal of small business strategy N2 - Both entrepreneurship and innovation play a key role for business growth and economic development and are conceptually highly intertwined. Both fields have received extensive attention that has resulted in a large number of publications. The aim of this work is to provide an overview on the coevolution of entrepreneurship and innovation over the last decades, with particular attention to recent research trends. To track the evolution at the intersection of both fields, we employ a bibliometric analysis, which allowed us to identify the key concepts, the backbone of research, and to provide a systematic classification of main research themes diagnosed including: 1) entrepreneurial innovation and digital transformation, 2) sustainable innovation and entrepreneurship, 3) product innovation and knowledge, 4) entrepreneurial orientation and leadership, and 5) regional entrepreneurship and innovation (innovative entrepreneurship and historical roots). The findings of this bibliometric review are reported in the form of a knowledge graph that represents the results obtained in terms of the knowledge base (key terms), knowledge domains, and knowledge evolution (themes and bursts), based on which themes for future research are suggested. KW - bibliometric analysis KW - literature review KW - innovation KW - entrepreneurship KW - knowledge graph Y1 - 2022 U6 - https://doi.org/10.53703/001c.29968 SN - 1081-8510 SN - 2380-1751 VL - 32 IS - 2 PB - Middle Tennessee State University CY - Murfreesboro, TN ER - TY - JOUR A1 - Czakon, Wojciech A1 - Klimas, Patrycja A1 - Tiberius, Victor A1 - Ferreira, João A1 - Veiga, Pedro M. A1 - Kraus, Sascha T1 - Entrepreneurial failure BT - structuring a widely overlooked field of research JF - Entrepreneurship research journal N2 - Although entrepreneurial failure (EF) is a fairly recent topic in entrepreneurship literature, the number of publications has been growing dynamically and particularly rapidly. Our systematic review maps and integrates the research on EF based on a multi-method approach to give structure and consistency to this fragmented field of research. The results reveal that the field revolves around six thematic clusters of EF: 1) Soft underpinnings of EF, 2) Contextuality of EF, 3) Perception of EF, 4) Two-sided effects of EF, 5) Multi-stage EF effects, and 6) Institutional drivers of EF. An integrative framework of the positive and negative effects of entrepreneurial failure is proposed, and a research agenda is suggested. KW - entrepreneurial failure KW - entrepreneurship KW - failure outcomes KW - systematic review Y1 - 2022 U6 - https://doi.org/10.1515/erj-2021-0328 SN - 2157-5665 SP - 1 EP - 34 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Simonini, Giovanni A1 - Zecchini, Luca A1 - Bergamaschi, Sonia A1 - Naumann, Felix T1 - Entity resolution on-demand JF - Proceedings of the VLDB Endowment N2 - Entity Resolution (ER) aims to identify and merge records that refer to the same real-world entity. ER is typically employed as an expensive cleaning step on the entire data before consuming it. Yet, determining which entities are useful once cleaned depends solely on the user's application, which may need only a fraction of them. For instance, when dealing with Web data, we would like to be able to filter the entities of interest gathered from multiple sources without cleaning the entire, continuously-growing data. Similarly, when querying data lakes, we want to transform data on-demand and return the results in a timely manner-a fundamental requirement of ELT (Extract-Load-Transform) pipelines. We propose BrewER, a framework to evaluate SQL SP queries on dirty data while progressively returning results as if they were issued on cleaned data. BrewER tries to focus the cleaning effort on one entity at a time, following an ORDER BY predicate. Thus, it inherently supports top-k and stop-and-resume execution. For a wide range of applications, a significant amount of resources can be saved. We exhaustively evaluate and show the efficacy of BrewER on four real-world datasets. Y1 - 2022 U6 - https://doi.org/10.14778/3523210.3523226 SN - 2150-8097 VL - 15 IS - 7 SP - 1506 EP - 1518 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Perscheid, Michael A1 - Plattner, Hasso A1 - Ritter, Daniel A1 - Schlosser, Rainer A1 - Teusner, Ralf T1 - Enterprise platform and integration concepts research at HPI JF - SIGMOD record N2 - The Hasso Plattner Institute (HPI), academically structured as the independent Faculty of Digital Engineering at the University of Potsdam, unites computer science research and teaching with the advantages of a privately financed institute and a tuition-free study program. Founder and namesake of the institute is the SAP co-founder Hasso Plattner, who also heads the Enterprise Platform and Integration Concepts (EPIC) research center which focuses on the technical aspects of business software with a vision to provide the fastest way to get insights out of enterprise data. Founded in 2006, the EPIC combines three research groups comprising autonomous data management, enterprise software engineering, and data-driven decision support. Y1 - 2023 U6 - https://doi.org/10.1145/3582302.3582322 SN - 0163-5808 SN - 1943-5835 VL - 51 IS - 4 SP - 68 EP - 73 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Vogel, Annemarie A1 - Claus, Inga A1 - Ahring, Sigrid A1 - Gruber, Doreen A1 - Haghikia, Aiden A1 - Frank, Ulrike A1 - Dziewas, Rainer A1 - Ebersbach, Georg A1 - Gandor, Florin A1 - Warnecke, Tobias T1 - Endoscopic characteristics of dysphagia in multiple system atrophy JF - Movement disorders : official journal of the Movement Disorder Society N2 - Background Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. Objective This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. Methods Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings. Results Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4%, piecemeal deglutition, 75.4%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9%; penetration/aspiration, 28.1%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8%, P < 0.001; piecemeal deglutition, 1.8%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85%, specificity 100%). Conclusions In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia. KW - multiple system atrophy KW - dysphagia KW - FEES KW - Swallowing Disturbance Questionnaire KW - SDQ Y1 - 2022 U6 - https://doi.org/10.1002/mds.28854 SN - 0885-3185 SN - 1531-8257 VL - 37 IS - 3 SP - 535 EP - 544 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Smith, Taylor A1 - Traxl, Dominik A1 - Boers, Niklas T1 - Empirical evidence for recent global shifts in vegetation resilience JF - Nature climate change N2 - The authors demonstrate that a vegetation system's ability to recover from disturbances-its resilience-can be estimated from its natural variability. Global patterns of resilience loss and gains since the early 1990s reveal shifts towards widespread resilience loss since the early 2000s. The character and health of ecosystems worldwide is tightly coupled to changes in Earth's climate. Theory suggests that ecosystem resilience-the ability of ecosystems to resist and recover from external shocks such as droughts and fires-can be inferred from their natural variability. Here, we quantify vegetation resilience globally with complementary metrics based on two independent long-term satellite records. We first empirically confirm that the recovery rates from large perturbations can be closely approximated from internal vegetation variability across vegetation types and climate zones. On the basis of this empirical relationship, we quantify vegetation resilience continuously and globally from 1992 to 2017. Long-term vegetation resilience trends are spatially heterogeneous, with overall increasing resilience in the tropics and decreasing resilience at higher latitudes. Shorter-term trends, however, reveal a marked shift towards a global decline in vegetation resilience since the early 2000s, particularly in the equatorial rainforest belt. Y1 - 2022 U6 - https://doi.org/10.1038/s41558-022-01352-2 SN - 1758-678X SN - 1758-6798 VL - 12 IS - 5 SP - 477 EP - 484 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Schaefer, Laura A1 - Dech, Silas A1 - Wolff, Lara L. A1 - Bittmann, Frank T1 - Emotional Imagery Influences the Adaptive Force in Young Women BT - Unpleasant Imagery Reduces Instantaneously the Muscular Holding Capacity JF - Brain Sciences N2 - The link between emotions and motor function has been known for decades but is still not clarified. The Adaptive Force (AF) describes the neuromuscular capability to adapt to increasing forces and was suggested to be especially vulnerable to interfering inputs. This study investigated the influence of pleasant an unpleasant food imagery on the manually assessed AF of elbow and hip flexors objectified by a handheld device in 12 healthy women. The maximal isometric AF was significantly reduced during unpleasant vs. pleasant imagery and baseline (p < 0.001, dz = 0.98–1.61). During unpleasant imagery, muscle lengthening started at 59.00 ± 22.50% of maximal AF, in contrast to baseline and pleasant imagery, during which the isometric position could be maintained mostly during the entire force increase up to ~97.90 ± 5.00% of maximal AF. Healthy participants showed an immediately impaired holding function triggered by unpleasant imagery, presumably related to negative emotions. Hence, AF seems to be suitable to test instantaneously the effect of emotions on motor function. Since musculoskeletal complaints can result from muscular instability, the findings provide insights into the understanding of the causal chain of linked musculoskeletal pain and mental stress. A case example (current stress vs. positive imagery) suggests that the approach presented in this study might have future implications for psychomotor diagnostics and therapeutics. KW - Adaptive Force KW - maximal isometric Adaptive Force KW - holding capability KW - neuromuscular adaptation KW - motor control KW - pleasant and unpleasant imagery KW - emotions KW - emotional imagery KW - manual muscle test Y1 - 2022 U6 - https://doi.org/10.3390/brainsci12101318 SN - 2076-3425 VL - 12 IS - 10 PB - MDPI CY - Basel, Schweiz ER - TY - JOUR A1 - Kleanthis, Nikos A1 - Stavrakas, Vassilis A1 - Ceglarz, Andrzej A1 - Süsser, Diana A1 - Schibline, Amanda A1 - Lilliestam, Johan A1 - Flamos, Alexandros T1 - Eliciting knowledge from stakeholders to identify critical issues of the transition to climate neutrality in Greece, the Nordic Region, and the European Union JF - Energy research & social ccience N2 - There are considerable differences in the pace and underlying motivations of the energy transition in the different geographical contexts across Europe. The European Union's commitment to climate neutrality by 2050 requires a better understanding of the energy transition in different contexts and scales to improve cooperation of involved actors. In this article, we identify critical issues and challenges of the European energy transition as perceived by stakeholders and investigate how these perceptions vary across geographical contexts. To do so, we couple a policy document analysis with research based on stakeholder engagement activities in three different scales, national (Greece), regional (Nordic Region) and continental scale (European Union). Our findings show that stakeholder perspectives on the energy transition depend on contextual factors underlying the need for policies sensitive to the different transition issues and challenges in European regions. They also reveal cross-cutting issues and challenges among the three case studies, which could lead to further improvement of the cross-country collaboration to foster the European energy transition. KW - challenges KW - case studies KW - energy policy KW - energy transition KW - climate neutrality KW - stakeholder engagement Y1 - 2022 U6 - https://doi.org/10.1016/j.erss.2022.102836 SN - 2214-6296 VL - 93 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Birukov, Anna A1 - Glintborg, Dorte A1 - Schulze, Matthias B. A1 - Jensen, Tina K. A1 - Kuxhaus, Olga A1 - Andersen, Louise B. A1 - Kräker, Kristin A1 - Polemiti, Elli A1 - Jensen, Boye L. A1 - Jørgensen, Jan S. A1 - Dechend, Ralf A1 - Andersen, Marianne S. T1 - Elevated blood pressure in pregnant women with gestational diabetes according to the WHO criteria: importance of overweight JF - Journal of hypertension N2 - Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings in a population-based cohort of pregnant women, who were stratified according to their metabolic status in early third trimester. Methods: We recorded blood pressure longitudinally during pregnancy in 1230 women from the Odense Child Cohort, Denmark. Fasting glucose and insulin were measured at gestational weeks 28-30. Metabolic status was evaluated according to the WHO 2013 threshold for GDM (GDM-WHO: fasting plasma glucose >= 5.1 mmol/l), insulin and homeostatic model assessment of insulin resistance (HOMA-IR). Relationships between metabolic status in third trimester and blood pressure trajectories were evaluated with adjusted linear mixed models. Trajectory was defined as blood pressure records in pregnancy per 4 weeks interval. Results: Prevalence of GDM-WHO was 40% (498/1230). GDM-WHO was associated with 1.46 (0.22-2.70) mmHg higher SBP and 1.04 (0.07-2.01) mmHg higher DBP trajectories in the overall cohort. The associations were driven by differences in the overweight group, with 3.14 (1.05-5.25) mmHg higher SBP and 1.94 (0.42-3.47) mmHg higher DBP per 4 weeks in women with GDM-WHO compared with women without GDM-WHO. GDM-WHO was not associated with blood pressure in women with normal weight. Blood pressure trajectories were elevated across quartiles of insulin resistance. Conclusion: GDM-WHO is associated with higher blood pressure in pregnancy, and there appears to be a stronger effect in overweight women. KW - blood pressure KW - gestational diabetes mellitus KW - insulin resistance KW - overweight KW - pregnancy KW - WHO Y1 - 2022 U6 - https://doi.org/10.1097/HJH.0000000000003196 SN - 0263-6352 SN - 1473-5598 VL - 40 IS - 8 SP - 1614 EP - 1623 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Eiserbeck, Anna A1 - Enge, Alexander A1 - Rabovsky, Milena A1 - Abdel Rahman, Rasha T1 - Electrophysiological chronometry of graded consciousness during the attentional blink JF - Cerebral cortex N2 - One of the ongoing debates about visual consciousness is whether it can be considered as an all-or-none or a graded phenomenon. While there is increasing evidence for the existence of graded states of conscious awareness based on paradigms such as visual masking, only little and mixed evidence is available for the attentional blink paradigm, specifically in regard to electrophysiological measures. Thereby, the all-or-none pattern reported in some attentional blink studies might have originated from specifics of the experimental design, suggesting the need to examine the generalizability of results. In the present event-related potential (ERP) study (N = 32), visual awareness of T2 face targets was assessed via subjective visibility ratings on a perceptual awareness scale in combination with ERPs time-locked to T2 onset (components P1, N1, N2, and P3). Furthermore, a classification task preceding visibility ratings allowed to track task performance. The behavioral results indicate a graded rather than an all-or-none pattern of visual awareness. Corresponding graded differences in the N1, N2, and P3 components were observed for the comparison of visibility levels. These findings suggest that conscious perception during the attentional blink can occur in a graded fashion. KW - attentional blink KW - consciousness KW - event-related potentials KW - neural KW - correlates of consciousness KW - perceptual awareness scale Y1 - 2021 U6 - https://doi.org/10.1093/cercor/bhab289 SN - 1047-3211 SN - 1460-2199 VL - 32 IS - 6 SP - 1244 EP - 1259 PB - Oxford University Press CY - New York, NY ER - TY - JOUR A1 - Heinsohn, Natascha Katharina A1 - Niedl, Robert Raimund A1 - Anielski, Alexander A1 - Lisdat, Fred A1 - Beta, Carsten T1 - Electrophoretic mu PAD for purification and analysis of DNA samples JF - Biosensors : open access journal N2 - In this work, the fabrication and characterization of a simple, inexpensive, and effective microfluidic paper analytic device (mu PAD) for monitoring DNA samples is reported. The glass microfiber-based chip has been fabricated by a new wax-based transfer-printing technique and an electrode printing process. It is capable of moving DNA effectively in a time-dependent fashion. The nucleic acid sample is not damaged by this process and is accumulated in front of the anode, but not directly on the electrode. Thus, further DNA processing is feasible. The system allows the DNA to be purified by separating it from other components in sample mixtures such as proteins. Furthermore, it is demonstrated that DNA can be moved through several layers of the glass fiber material. This proof of concept will provide the basis for the development of rapid test systems, e.g., for the detection of pathogens in water samples. KW - microfluidic paper analytic device (mu PAD) KW - patterning glass microfiber KW - fiber-electrophoresis chip KW - DNA KW - imprinted electrodes KW - cross layer chip KW - polymerase chain reaction (PCR) KW - purification Y1 - 2022 U6 - https://doi.org/10.3390/bios12020062 SN - 2079-6374 VL - 12 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Roy, Parna A1 - Mukherjee, Arpita A1 - Mondal, Pritha A1 - Bhattacharyya, Biswajit A1 - Narayan, Awadhesh A1 - Pandey, Anshu T1 - Electronic structure and spectroscopy of I-III-VI2 nanocrystals BT - a perspective JF - The journal of physical chemistry : C, Nanomaterials and interfaces N2 - I-III-VI2 semiconductor nanocrystals have been applied to a host of energy conversion devices with great success. Large scale implementation of device concepts based on these materials has, however, been somewhat stymied by the strong role of defects in determining the optoelectronic characteristics of these materials. Here we present a perspective view of the role of electronic structure and defects on the physical properties, particularly the spectroscopy, of this family of materials. Applications of these materials are further discussed in this context. Y1 - 2022 U6 - https://doi.org/10.1021/acs.jpcc.1c10922 SN - 1932-7447 SN - 1932-7455 VL - 126 IS - 17 SP - 7364 EP - 7373 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Mattern, Maximilian A1 - Reppert, Alexander von A1 - Zeuschner, Steffen Peer A1 - Pudell, Jan-Etienne A1 - Kühne, F. A1 - Diesing, Detlef A1 - Herzog, Marc A1 - Bargheer, Matias T1 - Electronic energy transport in nanoscale Au/Fe hetero-structures in the perspective of ultrafast lattice dynamics JF - Applied physics letters N2 - We study the ultrafast electronic transport of energy in a photoexcited nanoscale Au/Fe hetero-structure by modeling the spatiotemporal profile of energy densities that drives transient strain, which we quantify by femtosecond x-ray diffraction. This flow of energy is relevant for intrinsic demagnetization and ultrafast spin transport. We measured lattice strain for different Fe layer thicknesses ranging from few atomic layers to several nanometers and modeled the spatiotemporal flow of energy densities. The combination of a high electron-phonon coupling coefficient and a large Sommerfeld constant in Fe is found to yield electronic transfer of nearly all energy from Au to Fe within the first hundreds of femtoseconds. Y1 - 2022 U6 - https://doi.org/10.1063/5.0080378 SN - 0003-6951 SN - 1077-3118 VL - 120 IS - 9 PB - AIP Publishing CY - Melville ER - TY - JOUR A1 - Jafarnezhadgero, Amir Ali A1 - Fatollahi, Amir A1 - Granacher, Urs T1 - Eight weeks of exercising on sand has positive effects on biomechanics of walking and muscle activities in individuals with pronated feet BT - a randomized double-blinded controlled trial JF - Sports : open access journal N2 - This study aimed to investigate the effects of eight weeks of barefoot running exercise on sand versus control on measures of walking kinetics and muscle activities in individuals with diagnosed pronated feet. Sixty physically active male adults with pronated feet were randomly allocated into an intervention or a waiting control group. The intervention group conducted an 8-weeks progressive barefoot running exercise program on sand (e.g., short sprints) with three weekly sessions. Pre and post intervention, participants walked at a constant speed of 1.3 m/s +/- 5% on a 18 m walkway with a force plate embedded in the middle of the walkway. Results showed significant group-by-time interactions for peak impact vertical and lateral ground reaction forces. Training but not control resulted in significantly lower peak impact vertical and lateral ground reaction forces. Significant group-by-time interactions were observed for vastus lateralis activity during the loading phase. Training-induced increases were found for the vastus lateralis in the intervention but not in the control group. This study revealed that the applied exercise program is a suitable means to absorb ground reaction forces (e.g., lower impact vertical and lateral peaks) and increase activities of selected lower limb muscles (e.g., vastus lateralis) when walking on stable ground. KW - flat foot KW - free moment KW - gait KW - loading rate KW - training Y1 - 2022 U6 - https://doi.org/10.3390/sports10050070 SN - 2075-4663 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bläsius, Thomas A1 - Friedrich, Tobias A1 - Lischeid, Julius A1 - Meeks, Kitty A1 - Schirneck, Friedrich Martin T1 - Efficiently enumerating hitting sets of hypergraphs arising in data profiling JF - Journal of computer and system sciences : JCSS N2 - The transversal hypergraph problem asks to enumerate the minimal hitting sets of a hypergraph. If the solutions have bounded size, Eiter and Gottlob [SICOMP'95] gave an algorithm running in output-polynomial time, but whose space requirement also scales with the output. We improve this to polynomial delay and space. Central to our approach is the extension problem, deciding for a set X of vertices whether it is contained in any minimal hitting set. We show that this is one of the first natural problems to be W[3]-complete. We give an algorithm for the extension problem running in time O(m(vertical bar X vertical bar+1) n) and prove a SETH-lower bound showing that this is close to optimal. We apply our enumeration method to the discovery problem of minimal unique column combinations from data profiling. Our empirical evaluation suggests that the algorithm outperforms its worst-case guarantees on hypergraphs stemming from real-world databases. KW - Data profiling KW - Enumeration algorithm KW - Minimal hitting set KW - Transversal hypergraph KW - Unique column combination KW - W[3]-Completeness Y1 - 2022 U6 - https://doi.org/10.1016/j.jcss.2021.10.002 SN - 0022-0000 SN - 1090-2724 VL - 124 SP - 192 EP - 213 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Bläsius, Thomas A1 - Freiberger, Cedric A1 - Friedrich, Tobias A1 - Katzmann, Maximilian A1 - Montenegro-Retana, Felix A1 - Thieffry, Marianne T1 - Efficient Shortest Paths in Scale-Free Networks with Underlying Hyperbolic Geometry JF - ACM Transactions on Algorithms N2 - A standard approach to accelerating shortest path algorithms on networks is the bidirectional search, which explores the graph from the start and the destination, simultaneously. In practice this strategy performs particularly well on scale-free real-world networks. Such networks typically have a heterogeneous degree distribution (e.g., a power-law distribution) and high clustering (i.e., vertices with a common neighbor are likely to be connected themselves). These two properties can be obtained by assuming an underlying hyperbolic geometry.
To explain the observed behavior of the bidirectional search, we analyze its running time on hyperbolic random graphs and prove that it is (O) over tilde (n(2-1/alpha) + n(1/(2 alpha)) + delta(max)) with high probability, where alpha is an element of (1/2, 1) controls the power-law exponent of the degree distribution, and dmax is the maximum degree. This bound is sublinear, improving the obvious worst-case linear bound. Although our analysis depends on the underlying geometry, the algorithm itself is oblivious to it. KW - Random graphs KW - hyperbolic geometry KW - scale-free networks KW - bidirectional shortest path Y1 - 2022 U6 - https://doi.org/10.1145/3516483 SN - 1549-6325 SN - 1549-6333 VL - 18 IS - 2 SP - 1 EP - 32 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Schmidl, Sebastian A1 - Papenbrock, Thorsten T1 - Efficient distributed discovery of bidirectional order dependencies JF - The VLDB journal N2 - Bidirectional order dependencies (bODs) capture order relationships between lists of attributes in a relational table. They can express that, for example, sorting books by publication date in ascending order also sorts them by age in descending order. The knowledge about order relationships is useful for many data management tasks, such as query optimization, data cleaning, or consistency checking. Because the bODs of a specific dataset are usually not explicitly given, they need to be discovered. The discovery of all minimal bODs (in set-based canonical form) is a task with exponential complexity in the number of attributes, though, which is why existing bOD discovery algorithms cannot process datasets of practically relevant size in a reasonable time. In this paper, we propose the distributed bOD discovery algorithm DISTOD, whose execution time scales with the available hardware. DISTOD is a scalable, robust, and elastic bOD discovery approach that combines efficient pruning techniques for bOD candidates in set-based canonical form with a novel, reactive, and distributed search strategy. Our evaluation on various datasets shows that DISTOD outperforms both single-threaded and distributed state-of-the-art bOD discovery algorithms by up to orders of magnitude; it can, in particular, process much larger datasets. KW - Bidirectional order dependencies KW - Distributed computing KW - Actor KW - programming KW - Parallelization KW - Data profiling KW - Dependency discovery Y1 - 2021 U6 - https://doi.org/10.1007/s00778-021-00683-4 SN - 1066-8888 SN - 0949-877X VL - 31 IS - 1 SP - 49 EP - 74 PB - Springer CY - Berlin ; Heidelberg ; New York ER - TY - JOUR A1 - Huang, Daniel Zhengyu A1 - Huang, Jiaoyang A1 - Reich, Sebastian A1 - Stuart, Andrew M. T1 - Efficient derivative-free Bayesian inference for large-scale inverse problems JF - Inverse problems : an international journal of inverse problems, inverse methods and computerised inversion of data N2 - We consider Bayesian inference for large-scale inverse problems, where computational challenges arise from the need for repeated evaluations of an expensive forward model. This renders most Markov chain Monte Carlo approaches infeasible, since they typically require O(10(4)) model runs, or more. Moreover, the forward model is often given as a black box or is impractical to differentiate. Therefore derivative-free algorithms are highly desirable. We propose a framework, which is built on Kalman methodology, to efficiently perform Bayesian inference in such inverse problems. The basic method is based on an approximation of the filtering distribution of a novel mean-field dynamical system, into which the inverse problem is embedded as an observation operator. Theoretical properties are established for linear inverse problems, demonstrating that the desired Bayesian posterior is given by the steady state of the law of the filtering distribution of the mean-field dynamical system, and proving exponential convergence to it. This suggests that, for nonlinear problems which are close to Gaussian, sequentially computing this law provides the basis for efficient iterative methods to approximate the Bayesian posterior. Ensemble methods are applied to obtain interacting particle system approximations of the filtering distribution of the mean-field model; and practical strategies to further reduce the computational and memory cost of the methodology are presented, including low-rank approximation and a bi-fidelity approach. The effectiveness of the framework is demonstrated in several numerical experiments, including proof-of-concept linear/nonlinear examples and two large-scale applications: learning of permeability parameters in subsurface flow; and learning subgrid-scale parameters in a global climate model. Moreover, the stochastic ensemble Kalman filter and various ensemble square-root Kalman filters are all employed and are compared numerically. The results demonstrate that the proposed method, based on exponential convergence to the filtering distribution of a mean-field dynamical system, is competitive with pre-existing Kalman-based methods for inverse problems. KW - inverse problem KW - uncertainty quantification KW - Bayesian inference KW - derivative-free optimization KW - mean-field dynamical system KW - interacting particle system KW - ensemble Kalman filter Y1 - 2022 U6 - https://doi.org/10.1088/1361-6420/ac99fa SN - 0266-5611 SN - 1361-6420 VL - 38 IS - 12 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Grischek, Max A1 - Caprioglio, Pietro A1 - Zhang, Jiahuan A1 - Pena-Camargo, Francisco A1 - Sveinbjornsson, Kari A1 - Zu, Fengshuo A1 - Menzel, Dorothee A1 - Warby, Jonathan A1 - Li, Jinzhao A1 - Koch, Norbert A1 - Unger, Eva A1 - Korte, Lars A1 - Neher, Dieter A1 - Stolterfoht, Martin A1 - Albrecht, Steve T1 - Efficiency Potential and Voltage Loss of Inorganic CsPbI2Br Perovskite Solar Cells JF - Solar RRL N2 - Inorganic perovskite solar cells show excellent thermal stability, but the reported power conversion efficiencies are still lower than for organic-inorganic perovskites. This is mainly caused by lower open-circuit voltages (V(OC)s). Herein, the reasons for the low V-OC in inorganic CsPbI2Br perovskite solar cells are investigated. Intensity-dependent photoluminescence measurements for different layer stacks reveal that n-i-p and p-i-n CsPbI2Br solar cells exhibit a strong mismatch between quasi-Fermi level splitting (QFLS) and V-OC. Specifically, the CsPbI2Br p-i-n perovskite solar cell has a QFLS-e center dot V-OC mismatch of 179 meV, compared with 11 meV for a reference cell with an organic-inorganic perovskite of similar bandgap. On the other hand, this study shows that the CsPbI2Br films with a bandgap of 1.9 eV have a very low defect density, resulting in an efficiency potential of 20.3% with a MeO-2PACz hole-transporting layer and 20.8% on compact TiO2. Using ultraviolet photoelectron spectroscopy measurements, energy level misalignment is identified as a possible reason for the QFLS-e center dot V-OC mismatch and strategies for overcoming this V-OC limitation are discussed. This work highlights the need to control the interfacial energetics in inorganic perovskite solar cells, but also gives promise for high efficiencies once this issue is resolved. KW - CsPbI2Br KW - efficiency potentials KW - inorganic perovskites KW - photoluminescence KW - solar cells KW - voltage losses Y1 - 2022 U6 - https://doi.org/10.1002/solr.202200690 SN - 2367-198X VL - 6 IS - 11 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Delfan, Maryam A1 - Vahed, Alieh A1 - Bishop, David A1 - Juybari, Raheleh Amadeh A1 - Laher, Ismail A1 - Saeidi, Ayoub A1 - Granacher, Urs A1 - Zouhal, Hassane T1 - Effects of two workload-matched high-intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats JF - Frontiers in Physiology N2 - Aims: High intensity interval training (HIIT) improves mitochondrial characteristics. This study compared the impact of two workload-matched high intensity interval training (HIIT) protocols with different work:recovery ratios on regulatory factors related to mitochondrial biogenesis in the soleus muscle of diabetic rats. Materials and methods: Twenty-four Wistar rats were randomly divided into four equal-sized groups: non-diabetic control, diabetic control (DC), diabetic with long recovery exercise [4–5 × 2-min running at 80%–90% of the maximum speed reached with 2-min of recovery at 40% of the maximum speed reached (DHIIT1:1)], and diabetic with short recovery exercise (5–6 × 2-min running at 80%–90% of the maximum speed reached with 1-min of recovery at 30% of the maximum speed reached [DHIIT2:1]). Both HIIT protocols were completed five times/week for 4 weeks while maintaining equal running distances in each session. Results: Gene and protein expressions of PGC-1α, p53, and citrate synthase of the muscles increased significantly following DHIIT1:1 and DHIIT2:1 compared to DC (p ˂ 0.05). Most parameters, except for PGC-1α protein (p = 0.597), were significantly higher in DHIIT2:1 than in DHIIT1:1 (p ˂ 0.05). Both DHIIT groups showed significant increases in maximum speed with larger increases in DHIIT2:1 compared with DHIIT1:1. Conclusion: Our findings indicate that both HIIT protocols can potently up-regulate gene and protein expression of PGC-1α, p53, and CS. However, DHIIT2:1 has superior effects compared with DHIIT1:1 in improving mitochondrial adaptive responses in diabetic rats. KW - diabetes mellitus KW - muscle metabolism KW - time-efficient exercise KW - mitochondrial adaptation KW - exercise training Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.927969 SN - 1664-042X SP - 1 EP - 12 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Hannigan, Sara A1 - Nendel, Claas A1 - Krull, Marcos T1 - Effects of temperature on the movement and feeding behaviour of the large lupine beetle, Sitona gressorius JF - Journal of pest science N2 - Even though the effects of insect pests on global agricultural productivity are well recognised, little is known about movement and dispersal of many species, especially in the context of global warming. This work evaluates how temperature and light conditions affect different movement metrics and the feeding rate of the large lupine beetle, an agricultural pest responsible for widespread damage in leguminous crops. By using video recordings, the movement of 384 beetles was digitally analysed under six different temperatures and light conditions in the laboratory. Bayesian linear mixed-effect models were used to analyse the data. Furthermore, the effects of temperature on the daily diffusion coefficient of beetles were estimated by using hidden Markov models and random walk simulations. Results of this work show that temperature, light conditions, and beetles' weight were the main factors affecting the flight probability, displacement, time being active and the speed of beetles. Significant variations were also observed in all evaluated metrics. On average, beetles exposed to light conditions and higher temperatures had higher mean speed and flight probability. However, beetles tended to stay more active at higher temperatures and less active at intermediate temperatures, around 20 degrees C. Therefore, both the diffusion coefficient and displacement of beetles were lower at intermediate temperatures. These results show that the movement behaviour and feeding rates of beetles can present different relationships in the function of temperature. It also shows that using a single diffusion coefficient for insects in spatially explicit models may lead to over- or underestimation of pest spread. KW - Agricultural pests KW - Diffusion KW - Hidden Markov models KW - Movement ecology Y1 - 2022 U6 - https://doi.org/10.1007/s10340-022-01510-7 SN - 1612-4758 SN - 1612-4766 SP - 389 EP - 402 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Lenkeit, Jenny A1 - Hartmann, Anne A1 - Ehlert, Antje A1 - Knigge, Michel A1 - Spörer, Nadine T1 - Effects of special educational needs and socioeconomic status on academic achievement BT - Separate or confounded? JF - International Journal of Educational Research N2 - Germany is continuously expanding its inclusive education system. Research provides evidence that students with special educational needs (SEN) in inclusive school settings show lower academic achievement and come from lower socioeconomic backgrounds than their peers without SEN. Identifying to what extent the disadvantages originating from both characteristics are confounded in predicting academic achievement, has been neglected in the German educational context. Using data of 1711 primary and secondary school students from a longitudinal study in the state of Brandenburg, this study evaluates to what degree SEN (in the areas of learning and emotional-social difficulties) and socioeconomic background (SES) are confounded in predicting academic initial achievement in reading and mathematics as well as their development over time. Using multilevel modelling techniques that nest three measurement points into students and students into classes, results identify SES and SEN as relevant predictors of achievement status and growth in both subjects. Only few and small mediation effects of SES were found, indicating that both SES and SEN remain independent risk factors for achievement. Understanding the origins of student disadvantage can help teachers to make better informed choices for designing support measures and aid policymakers' reasoning for resource allocations. KW - Special educational needs KW - Socioeconomic background KW - Multiple disparities KW - Longitudinal KW - Hierarchical linear modelling Y1 - 2022 U6 - https://doi.org/10.1016/j.ijer.2022.101957 SN - 0883-0355 VL - 113 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Singh, Gaurav A1 - Kushwah, Gaurav Singh A1 - Singh, Tanvi A1 - Thapa, Rohit Kumar A1 - Granacher, Urs A1 - Ramirez-Campillo, Rodrigo T1 - Effects of sand-based plyometric-jump training in combination with endurance running on outdoor or treadmill surface on physical fitness in young adult males JF - Journal of sports science & medicine N2 - This study aimed at examining the effects of nine weeks of sand-based plyometric jump training (PJT) combined with endurance running on either outdoor or treadmill surface on measures of physical fitness. Male participants (age, 20.1 +/- 1.7 years) were randomly assigned to a sand-based PJT combined with endurance running on outdoor surface (OT, n = 25) or treadmill surface (TT, n = 25). The endurance miming intervention comprised a mixed training method, i.e., long slow distance, tempo, and interval running drills. A control group was additionally included in this study (CG, n = 25). Participants in CG followed their regular physical activity as OT and TT but did not receive any specific intervention. Individuals were assessed for their 50-m linear sprint time, standing long jump (SLJ) distance, cardiorespiratory fitness (i.e., Cooper test), forced vital capacity (FVC), calf girth, and resting heart rate (RHR). A three (groups: OT, TT, CG) by two (time: pre, post) ANOVA for repeated measures was used to analyze the exercise-specific effects. In case of significant group-by-time interactions, Bonferroni adjusted paired (within-group) and independent (between-group comparisons at post) t-tests were used for post-hoc analyses. Significant group-by-time interactions were found for all dependent variables (p < 0.001 - 0.002, eta(2)(p) = 0.16 - 0.78). Group-specific post-hoc tests showed improvements for all variables after OT (p < 0.001, Hedges'g effect size [g] = 0.05 - 1.94) and TT (p < 0.001, g = 0.04 - 2.73), but not in the CG (p = 0.058 - 1.000, g = 0.00 - 0.34). Compared to CG, OT showed larger SLJ (p = 0.001), cardiorespiratory fitness (p = 0.004), FVC (p = 0.008), and RHR (p < 0.001) improvements. TT showed larger improvements in SLJ (p = 0.036), cardiorespiratory fitness (p < 0.001), and RHR (p < 0.001) compared with CG. Compared to OT, TT showed larger improvements for SLJ (p = 0.018). In conclusion, sand-based PJT combined with either OT or TT similarly improved most measures of physical fitness, with greater SLJ improvement after TT. Coaches may use both concurrent exercise regimes based on preferences and logistical constrains (e.g., weather; access to treadmill equipment). KW - Muscle strength KW - musculoskeletal and neural physiological phenomena KW - movement KW - resistance training KW - high-intensity interval training KW - exercise Y1 - 2022 U6 - https://doi.org/10.52082/jssm.2022.277 SN - 1303-2968 VL - 21 IS - 2 SP - 277 EP - 286 PB - Department of Sports Medicine, Medical Faculty of Uludag University CY - Bursa ER - TY - JOUR A1 - Jafarnezhadgero, Amir Ali A1 - Amirzadeh, Nasrin A1 - Fatollahi, Amir A1 - Siahkouhian, Marefat A1 - de Souza Castelo Oliveira, Anderson A1 - Granacher, Urs T1 - Effects of running on sand vs. stable ground on kinetics and muscle activities in individuals with over-pronated feet JF - Frontiers in physiology / Frontiers Research Foundation N2 - Background: In terms of physiological and biomechanical characteristics, over-pronation of the feet has been associated with distinct muscle recruitment patterns and ground reaction forces during running. Objective: The aim of this study was to evaluate the effects of running on sand vs. stable ground on ground-reaction-forces (GRFs) and electromyographic (EMG) activity of lower limb muscles in individuals with over-pronated feet (OPF) compared with healthy controls. Methods: Thirty-three OPF individuals and 33 controls ran at preferred speed and in randomized-order over level-ground and sand. A force-plate was embedded in an 18-m runway to collect GRFs. Muscle activities were recorded using an EMG-system. Data were adjusted for surface-related differences in running speed. Results: Running on sand resulted in lower speed compared with stable ground running (p < 0.001; d = 0.83). Results demonstrated that running on sand produced higher tibialis anterior activity (p = 0.024; d = 0.28). Also, findings indicated larger loading rates (p = 0.004; d = 0.72) and greater vastus medialis (p < 0.001; d = 0.89) and rectus femoris (p = 0.001; d = 0.61) activities in OPF individuals. Controls but not OPF showed significantly lower gluteus-medius activity (p = 0.022; d = 0.63) when running on sand. Conclusion: Running on sand resulted in lower running speed and higher tibialis anterior activity during the loading phase. This may indicate alterations in neuromuscular demands in the distal part of the lower limbs when running on sand. In OPF individuals, higher loading rates together with greater quadriceps activity may constitute a proximal compensatory mechanism for distal surface instability. KW - flat feet KW - loading rate KW - lower limb mechanics KW - unstable walkway KW - muscle Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2021.822024 SN - 1664-042X VL - 12 SP - 1 EP - 10 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Ramirez-Campillo, Rodrigo A1 - Pérez-Castilla, Alejandro A1 - Thapa, Rohit Kumar A1 - Afonso, José A1 - Clemente, Filipe Manuel Batista A1 - Colado, Juan C. A1 - Eduardo, Saéz de Villarreal A1 - Chaabene, Helmi T1 - Effects of Plyometric Jump Training on Measures of Physical Fitness and Sport-Specific Performance of Water Sports Athletes BT - A Systematic Review with Meta-analysis JF - Sports Medicine - Open N2 - Background A growing body of literature is available regarding the effects of plyometric jump training (PJT) on measures of physical fitness (PF) and sport-specific performance (SSP) in-water sports athletes (WSA, i.e. those competing in sports that are practiced on [e.g. rowing] or in [e.g. swimming; water polo] water). Indeed, incoherent findings have been observed across individual studies making it difficult to provide the scientific community and coaches with consistent evidence. As such, a comprehensive systematic literature search should be conducted to clarify the existent evidence, identify the major gaps in the literature, and offer recommendations for future studies. Aim To examine the effects of PJT compared with active/specific-active controls on the PF (one-repetition maximum back squat strength, squat jump height, countermovement jump height, horizontal jump distance, body mass, fat mass, thigh girth) and SSP (in-water vertical jump, in-water agility, time trial) outcomes in WSA, through a systematic review with meta-analysis of randomized and non-randomized controlled studies. Methods The electronic databases PubMed, Scopus, and Web of Science were searched up to January 2022. According to the PICOS approach, the eligibility criteria were: (population) healthy WSA; (intervention) PJT interventions involving unilateral and/or bilateral jumps, and a minimal duration of ≥ 3 weeks; (comparator) active (i.e. standard sports training) or specific-active (i.e. alternative training intervention) control group(s); (outcome) at least one measure of PF (e.g. jump height) and/or SSP (e.g. time trial) before and after training; and (study design) multi-groups randomized and non-randomized controlled trials. The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodological quality of the included studies. The DerSimonian and Laird random-effects model was used to compute the meta-analyses, reporting effect sizes (ES, i.e. Hedges’ g) with 95% confidence intervals (95% CIs). Statistical significance was set at p ≤ 0.05. Certainty or confidence in the body of evidence for each outcome was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE), considering its five dimensions: risk of bias in studies, indirectness, inconsistency, imprecision, and risk of publication bias. Results A total of 11,028 studies were identified with 26 considered eligible for inclusion. The median PEDro score across the included studies was 5.5 (moderate-to-high methodological quality). The included studies involved a total of 618 WSA of both sexes (330 participants in the intervention groups [31 groups] and 288 participants in the control groups [26 groups]), aged between 10 and 26 years, and from different sports disciplines such as swimming, triathlon, rowing, artistic swimming, and water polo. The duration of the training programmes in the intervention and control groups ranged from 4 to 36 weeks. The results of the meta-analysis indicated no effects of PJT compared to control conditions (including specific-active controls) for in-water vertical jump or agility (ES =  − 0.15 to 0.03; p = 0.477 to 0.899), or for body mass, fat mass, and thigh girth (ES = 0.06 to 0.15; p = 0.452 to 0.841). In terms of measures of PF, moderate-to-large effects were noted in favour of the PJT groups compared to the control groups (including specific-active control groups) for one-repetition maximum back squat strength, horizontal jump distance, squat jump height, and countermovement jump height (ES = 0.67 to 1.47; p = 0.041 to < 0.001), in addition to a small effect noted in favour of the PJT for SSP time-trial speed (ES = 0.42; p = 0.005). Certainty of evidence across the included studies varied from very low-to-moderate. Conclusions PJT is more effective to improve measures of PF and SSP in WSA compared to control conditions involving traditional sport-specific training as well as alternative training interventions (e.g. resistance training). It is worth noting that the present findings are derived from 26 studies of moderate-to-high methodological quality, low-to-moderate impact of heterogeneity, and very low-to-moderate certainty of evidence based on GRADE. Trial registration The protocol for this systematic review with meta-analysis was published in the Open Science platform (OSF) on January 23, 2022, under the registration doi https://doi.org/10.17605/OSF.IO/NWHS3 (internet archive link: https://archive.org/details/osf-registrations-nwhs3-v1). KW - Plyometric exercise KW - Musculoskeletal and neural physiological phenomena KW - Human physical conditioning KW - Movement KW - Muscle strength KW - Resistance training Y1 - 2022 U6 - https://doi.org/10.1186/s40798-022-00502-2 SN - 2198-9761 VL - 8 SP - 1 EP - 27 PB - Springer CY - Berlin ER - TY - JOUR A1 - Gebel, Arnd A1 - Busch, Aglaja A1 - Stelzel, Christine A1 - Hortobágyi, Tibor A1 - Granacher, Urs T1 - Effects of Physical and Mental Fatigue on Postural Sway and Cortical Activity in Healthy Young Adults JF - Frontiers in Human Neuroscience N2 - Physical fatigue (PF) negatively affects postural control, resulting in impaired balance performance in young and older adults. Similar effects on postural control can be observed for mental fatigue (MF) mainly in older adults. Controversial results exist for young adults. There is a void in the literature on the effects of fatigue on balance and cortical activity. Therefore, this study aimed to examine the acute effects of PF and MF on postural sway and cortical activity. Fifteen healthy young adults aged 28 ± 3 years participated in this study. MF and PF protocols comprising of an all-out repeated sit-to-stand task and a computer-based attention network test, respectively, were applied in random order. Pre and post fatigue, cortical activity and postural sway (i.e., center of pressure displacements [CoPd], velocity [CoPv], and CoP variability [CV CoPd, CV CoPv]) were tested during a challenging bipedal balance board task. Absolute spectral power was calculated for theta (4–7.5 Hz), alpha-2 (10.5–12.5 Hz), beta-1 (13–18 Hz), and beta-2 (18.5–25 Hz) in frontal, central, and parietal regions of interest (ROI) and baseline-normalized. Inference statistics revealed a significant time-by-fatigue interaction for CoPd (p = 0.009, d = 0.39, Δ 9.2%) and CoPv (p = 0.009, d = 0.36, Δ 9.2%), and a significant main effect of time for CoP variability (CV CoPd: p = 0.001, d = 0.84; CV CoPv: p = 0.05, d = 0.62). Post hoc analyses showed a significant increase in CoPd (p = 0.002, d = 1.03) and CoPv (p = 0.003, d = 1.03) following PF but not MF. For cortical activity, a significant time-by-fatigue interaction was found for relative alpha-2 power in parietal (p < 0.001, d = 0.06) areas. Post hoc tests indicated larger alpha-2 power increases after PF (p < 0.001, d = 1.69, Δ 3.9%) compared to MF (p = 0.001, d = 1.03, Δ 2.5%). In addition, changes in parietal alpha-2 power and measures of postural sway did not correlate significantly, irrespective of the applied fatigue protocol. No significant changes were found for the other frequency bands, irrespective of the fatigue protocol and ROI under investigation. Thus, the applied PF protocol resulted in increased postural sway (CoPd and CoPv) and CoP variability accompanied by enhanced alpha-2 power in the parietal ROI while MF led to increased CoP variability and alpha-2 power in our sample of young adults. Potential underlying cortical mechanisms responsible for the greater increase in parietal alpha-2 power after PF were discussed but could not be clearly identified as cause. Therefore, further future research is needed to decipher alternative interpretations. KW - balance KW - cognitive/muscular fatigue KW - EEG KW - theta KW - alpha-2 Y1 - 2022 U6 - https://doi.org/10.3389/fnhum.2022.871930 SN - 1662-5161 VL - 16 SP - 1 EP - 14 PB - Frontiers Media S.A. CY - Lausanne, Schweiz ER -