TY  - JOUR
A1  - Tenenboim, Hezi
A1  - Smirnova, Julia
A1  - Willmitzer, Lothar
A1  - Steup, Martin
A1  - Brotman, Yariv
T1  - VMP1-deficient Chlamydomonas exhibits severely aberrant cell morphology and disrupted cytokinesies
JF  - BMC plant biology
N2  - Background: The versatile Vacuole Membrane Protein 1 (VMP1) has been previously investigated in six species. It has been shown to be essential in macroautophagy, where it takes part in autophagy initiation. In addition, VMP1 has been implicated in organellar biogenesis; endo-, exo- and phagocytosis, and protein secretion; apoptosis; and cell adhesion. These roles underly its proven involvement in pancreatitis, diabetes and cancer in humans.
 Results: In this study we analyzed a VMP1 homologue from the green alga Chlamydomonas reinhardtii. CrVMP1 knockdown lines showed severe phenotypes, mainly affecting cell division as well as the morphology of cells and organelles. We also provide several pieces of evidence for its involvement in macroautophagy.
KW  - VMP1
KW  - Autophagy
KW  - Cytokinesis
Y1  - 2014
U6  - https://doi.org/10.1186/1471-2229-14-121
SN  - 1471-2229
VL  - 14
PB  - BioMed Central
CY  - London
ER  -