TY  - JOUR
A1  - Aich, Valentin
A1  - Liersch, Stefan
A1  - Vetter, Tobias
A1  - Andersson, Jafet C. M.
A1  - Müller, Eva Nora
A1  - Hattermann, Fred
T1  - Climate or Land Use?
BT  - Attribution of Changes in River Flooding in the Sahel Zone
JF  - Water
N2  - This study intends to contribute to the ongoing discussion on whether land use and land cover changes (LULC) or climate trends have the major influence on the observed increase of flood magnitudes in the Sahel. A simulation-based approach is used for attributing the observed trends to the postulated drivers. For this purpose, the ecohydrological model SWIM (Soil and Water Integrated Model) with a new, dynamic LULC module was set up for the Sahelian part of the Niger River until Niamey, including the main tributaries Sirba and Goroul. The model was driven with observed, reanalyzed climate and LULC data for the years 1950-2009. In order to quantify the shares of influence, one simulation was carried out with constant land cover as of 1950, and one including LULC. As quantitative measure, the gradients of the simulated trends were compared to the observed trend. The modeling studies showed that for the Sirba River only the simulation which included LULC was able to reproduce the observed trend. The simulation without LULC showed a positive trend for flood magnitudes, but underestimated the trend significantly. For the Goroul River and the local flood of the Niger River at Niamey, the simulations were only partly able to reproduce the observed trend. In conclusion, the new LULC module enabled some first quantitative insights into the relative influence of LULC and climatic changes. For the Sirba catchment, the results imply that LULC and climatic changes contribute in roughly equal shares to the observed increase in flooding. For the other parts of the subcatchment, the results are less clear but show, that climatic changes and LULC are drivers for the flood increase; however their shares cannot be quantified. Based on these modeling results, we argue for a two-pillar adaptation strategy to reduce current and future flood risk: Flood mitigation for reducing LULC-induced flood increase, and flood adaptation for a general reduction of flood vulnerability.
Y1  - 2015
U6  - https://doi.org/10.3390/w7062796
SN  - 2073-4441
VL  - 7
IS  - 6
SP  - 2796
EP  - 2820
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Aich, Valentin
A1  - Liersch, Stefan
A1  - Vetter, T.
A1  - Huang, S.
A1  - Tecklenburg, J.
A1  - Hoffmann, P.
A1  - Koch, H.
A1  - Fournet, S.
A1  - Krysanova, Valentina
A1  - Mueller, N.
A1  - Hattermann, Fred
T1  - Comparing impacts of climate change on streamflow in four large African river basins
JF  - Hydrology and earth system sciences : HESS
N2  - This study aims to compare impacts of climate change on streamflow in four large representative African river basins: the Niger, the Upper Blue Nile, the Oubangui and the Limpopo. We set up the eco-hydrological model SWIM (Soil and Water Integrated Model) for all four basins individually. The validation of the models for four basins shows results from adequate to very good, depending on the quality and availability of input and calibration data.
 For the climate impact assessment, we drive the model with outputs of five bias corrected Earth system models of Coupled Model Intercomparison Project Phase 5 (CMIP5) for the representative concentration pathways (RCPs) 2.6 and 8.5. This climate input is put into the context of climate trends of the whole African continent and compared to a CMIP5 ensemble of 19 models in order to test their representativeness. Subsequently, we compare the trends in mean discharges, seasonality and hydrological extremes in the 21st century. The uncertainty of results for all basins is high. Still, climate change impact is clearly visible for mean discharges but also for extremes in high and low flows. The uncertainty of the projections is the lowest in the Upper Blue Nile, where an increase in streamflow is most likely. In the Niger and the Limpopo basins, the magnitude of trends in both directions is high and has a wide range of uncertainty. In the Oubangui, impacts are the least significant. Our results confirm partly the findings of previous continental impact analyses for Africa. However, contradictory to these studies we find a tendency for increased streamflows in three of the four basins (not for the Oubangui). Guided by these results, we argue for attention to the possible risks of increasing high flows in the face of the dominant water scarcity in Africa. In conclusion, the study shows that impact intercomparisons have added value to the adaptation discussion and may be used for setting up adaptation plans in the context of a holistic approach.
Y1  - 2014
U6  - https://doi.org/10.5194/hess-18-1305-2014
SN  - 1027-5606
SN  - 1607-7938
VL  - 18
IS  - 4
SP  - 1305
EP  - 1321
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Ahnert, Karsten
A1  - Pikovskij, Arkadij
T1  - Compactons and chaos in strongly nonlinear lattices
N2  - We study localized traveling waves and chaotic states in strongly nonlinear one-dimensional Hamiltonian lattices. We show that the solitary waves are superexponentially localized and present an accurate numerical method allowing one to find them for an arbitrary nonlinearity index. Compactons evolve from rather general initially localized perturbations and collide nearly elastically. Nevertheless, on a long time scale for finite lattices an extensive chaotic state is generally observed. Because of the system's scaling, these dynamical properties are valid for any energy.
Y1  - 2009
UR  - http://pre.aps.org/
U6  - https://doi.org/10.1103/Physreve.79.026209
SN  - 1539-3755
ER  - 
TY  - JOUR
A1  - Ahnert, Karsten
A1  - Abel, Markus
A1  - Kollosche, Matthias
A1  - Jorgensen, Per Jorgen
A1  - Kofod, Guggi
T1  - Soft capacitors for wave energy harvesting
JF  - Journal of materials chemistry
N2  - Wave energy harvesting could be a substantial renewable energy source without impact on the global climate and ecology, yet practical attempts have struggled with the problems of wear and catastrophic failure. An innovative technology for ocean wave energy harvesting was recently proposed, based on the use of soft capacitors. This study presents a realistic theoretical and numerical model for the quantitative characterization of this harvesting method. Parameter regions with optimal behavior are found, and novel material descriptors are determined, which dramatically simplify analysis. The characteristics of currently available materials are evaluated, and found to merit a very conservative estimate of 10 years for raw material cost recovery.
Y1  - 2011
U6  - https://doi.org/10.1039/c1jm12454d
SN  - 0959-9428
SN  - 1364-5501
VL  - 21
IS  - 38
SP  - 14492
EP  - 14497
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Ahnen, M. L.
A1  - Ansoldi, S.
A1  - Antonelli, L. A.
A1  - Arcaro, C.
A1  - Babie, A.
A1  - Banerjee, B.
A1  - Bangale, P.
A1  - de Almeida, U. Barres
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Bernardini, E.
A1  - Berti, A.
A1  - Biasuzzi, B.
A1  - Biland, A.
A1  - Blanch, O.
A1  - Bonnefoy, S.
A1  - Bonnoli, G.
A1  - Borracci, F.
A1  - Carosi, R.
A1  - Carosi, A.
A1  - Chatterjee, A.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Cumani, P.
A1  - Da Vela, P.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Lotto, B.
A1  - Wilhelmi, E. de Ona
A1  - Di Pierro, F.
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Dorner, D.
A1  - Doro, M.
A1  - Einecke, S.
A1  - Glawion, D. Eisenacher
A1  - Elsaesser, D.
A1  - Engelkemeier, M.
A1  - Ramazani, V. Fallah
A1  - Fernandez-Barra, A.
A1  - Fidalgo, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Fruck, C.
A1  - Galindo, D.
A1  - Lopez, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gaug, M.
A1  - Giammaria, P.
A1  - Godinovie, N.
A1  - Gora, D.
A1  - Griffiths, S.
A1  - Guberman, D.
A1  - Hadasch, D.
A1  - Hahn, A.
A1  - Hassan, T.
A1  - Hayashida, M.
A1  - Herrera, J.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Hughes, G.
A1  - Ishio, K.
A1  - Konno, Y.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - Kuvezdie, D.
A1  - Lelas, D.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Longo, F.
A1  - Lopez, M.
A1  - Lopez-Oramas, A.
A1  - Majumdar, P.
A1  - Makariev, M.
A1  - Maneva, G.
A1  - Manganaro, M.
A1  - Mannheim, K.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Menzel, U.
A1  - Minev, M.
A1  - Mirzoyan, R.
A1  - Moralejo, A.
A1  - Moreno, V.
A1  - Moretti, E.
A1  - Munar-Adrover, P.
A1  - Neustroev, V.
A1  - Niedzwiecki, A.
A1  - Rosillo, M. Nievas
A1  - Nilsson, K.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Paiano, S.
A1  - Palacio, J.
A1  - Paneque, D.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Paredes-Fortuny, X.
A1  - Pedaletti, G.
A1  - Peresano, M.
A1  - Perri, L.
A1  - Persic, M.
A1  - Moroni, P. G. Prada
A1  - Prandini, E.
A1  - Puljak, I.
A1  - Garcia, J. R.
A1  - Reichardt, I.
A1  - Rhode, W.
A1  - Riti, M.
A1  - Rico, J.
A1  - Saito, T.
A1  - Satalecka, K.
A1  - Schroeder, S.
A1  - Schweizer, T.
A1  - Shore, S. N.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Sobczynskall, D.
A1  - Stamerra, A.
A1  - Strzys, M.
A1  - Surie, T.
A1  - Takalo, L.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzie, T.
A1  - Tescaro, D.
A1  - Teshima, M.
A1  - Torres, D. F.
A1  - Torres-Alla, N.
A1  - Treves, A.
A1  - Vanzo, G.
A1  - Acosta, M. Vazquez
A1  - Vovk, I.
A1  - Ward, J. E.
A1  - Will, M.
A1  - Wu, M. H.
A1  - Zarie, D.
A1  - Abdalla, Hassan E.
A1  - Abramowski, A.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Akhperjanian, A. G.
A1  - Andersson, T.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arrieta, M.
A1  - Aubert, P.
A1  - Backes, M.
A1  - Balzer, A.
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Tjus, J. Becker
A1  - Berge, D.
A1  - Bernhard, S.
A1  - Bernlohr, K.
A1  - Blackwell, R.
A1  - Bottcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, J.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Btichele, M.
A1  - Bulik, T.
A1  - Capasso, M.
A1  - Carr, J.
A1  - Casanova, Sabrina
A1  - Cerruti, M.
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, R. C. G.
A1  - Chen, A.
A1  - Chevalier, J.
A1  - Chretien, M.
A1  - Coffaro, M.
A1  - Colafrancesco, S.
A1  - Cologna, G.
A1  - Condon, B.
A1  - Conrad, J.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Decock, J.
A1  - Degrange, B.
A1  - Dei, C.
A1  - Devin, J.
A1  - Dewilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Forster, A.
A1  - Funk, S.
A1  - Ftifiling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschal, D.
A1  - Goya, A.
A1  - Grondin, M. -H.
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hinton, J. A.
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Iwasaki, H.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jingo, M.
A1  - Jogler, T.
A1  - Jouvin, L.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzyfiski, K.
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluiniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, M.
A1  - Krtiger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, T.
A1  - Lorentz, M.
A1  - Liu, R.
A1  - Lopez-Coto, R.
A1  - Lypova, I.
A1  - Marandon, V.
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitche, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - Nakashima, S.
A1  - De Naurois, M.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ott, S.
A1  - Ohm, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, M.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Perennes, C.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pie, Q.
A1  - Pita, S.
A1  - Poon, H.
A1  - Prokhorov, D.
A1  - Prokoph, H.
A1  - Ptffilhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - De Los Reyes, R.
A1  - Richter, S.
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Safi-Harb, S.
A1  - Sahakian, V.
A1  - Saito, S.
A1  - Salek, D.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schtissler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Settimo, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shilon, I.
A1  - Simoni, R.
A1  - So, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stycz, K.
A1  - Sushch, I.
A1  - Takahashi, T.
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tibaldo, L.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - Van der Walt, D. J.
A1  - Van Eldik, C.
A1  - Van Rensburg, C.
A1  - Van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Vok, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Wornlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywuckan, N.
T1  - Constraints on particle acceleration in SS433/W50 from MAGIC and HESS observations
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Context. The large jet kinetic power and non-thermal processes occurring in the microquasar SS 433 make this source a good candidate for a very high-energy (VHE) gamma-ray emitter. Gamma-ray fluxes above the sensitivity limits of current Cherenkov telescopes have been predicted for both the central X-ray binary system and the interaction regions of SS 433 jets with the surrounding W50 nebula. Non-thermal emission at lower energies has been previously reported, indicating that efficient particle acceleration is taking place in the system. Aims. We explore the capability of SS 433 to emit VHE gamma rays during periods in which the expected flux attenuation due to periodic eclipses (P-orb similar to 13.1 days) and precession of the circumstellar disk (P-pre similar to 162 days) periodically covering the central binary system is expected to be at its minimum. The eastern and western SS 433/W50 interaction regions are also examined using the whole data set available. We aim to constrain some theoretical models previously developed for this system with our observations. Methods. We made use of dedicated observations from the Major Atmospheric Gamma Imaging Cherenkov telescopes (MAGIC) and High Energy Spectroscopic System (H.E.S.S.) of SS 433 taken from 2006 to 2011. These observation were combined for the first time and accounted for a total effective observation time of 16.5 h, which were scheduled considering the expected phases of minimum absorption of the putative VHE emission. Gamma-ray attenuation does not affect the jet/medium interaction regions. In this case, the analysis of a larger data set amounting to similar to 40-80 h, depending on the region, was employed. Results. No evidence of VHE gamma-ray emission either from the central binary system or from the eastern/western interaction regions was found. Upper limits were computed for the combined data set. Differential fluxes from the central system are found to be less than or similar to 10(-12)-10(-13) TeV-1 cm(-2) s(-1) in an energy interval ranging from similar to few x 100 GeV to similar to few TeV. Integral flux limits down to similar to 10(-12)-10(-13) ph cm(-2) s(-1) and similar to 10(-13)-10(-14) ph cm(-2) s(-1) are obtained at 300 and 800 GeV, respectively. Our results are used to place constraints on the particle acceleration fraction at the inner jet regions and on the physics of the jet/medium interactions. Conclusions. Our findings suggest that the fraction of the jet kinetic power that is transferred to relativistic protons must be relatively small in SS 433, q(p) <= 2.5 x 10(-5), to explain the lack of TeV and neutrino emission from the central system. At the SS 433/W50 interface, the presence of magnetic fields greater than or similar to 10 mu G is derived assuming a synchrotron origin for the observed X-ray emission. This also implies the presence of high-energy electrons with E-e up to 50 TeV, preventing an efficient production of gamma-ray fluxes in these interaction regions.
KW  - gamma rays: general
KW  - stars: black holes
KW  - X-rays: binaries
KW  - ISM: jets and outflows
Y1  - 2018
U6  - https://doi.org/10.1051/0004-6361/201731169
SN  - 1432-0746
VL  - 612
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Ahnen, M. L.
A1  - Ansoldi, S.
A1  - Antonelli, L. A.
A1  - Arcaro, C.
A1  - Babic, A.
A1  - Banerjee, B.
A1  - Bangale, P.
A1  - Barres de Almeida, U.
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Bernardini, E.
A1  - Berti, A.
A1  - Bhattacharyya, W.
A1  - Blanch, O.
A1  - Bonnoli, G.
A1  - Carosi, R.
A1  - Carosi, A.
A1  - Chatterjee, A.
A1  - Colak, S. M.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Cumani, P.
A1  - Da Vela, P.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Lotto, B.
A1  - Delfino, M.
A1  - Delgado, Jose Miguel Martins
A1  - Di Pierro, F.
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Doro, M.
A1  - Glawion, D. Eisenacher
A1  - Engelkemeier, M.
A1  - Ramazani, V. Fallah
A1  - Fernandez-Barral, A.
A1  - Fidalgo, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Fruck, C.
A1  - Galindo, D.
A1  - Lopez, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gaug, M.
A1  - Giammaria, P.
A1  - Godinovic, N.
A1  - Gora, D.
A1  - Guberman, D.
A1  - Hadasch, D.
A1  - Hahn, A.
A1  - Hassan, T.
A1  - Hayashida, M.
A1  - Herrera, J.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Ishio, K.
A1  - Konno, Y.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - Kuvezdic, D.
A1  - Lelas, D.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Longo, F.
A1  - Lopez, M.
A1  - Maggio, C.
A1  - Majumdar, P.
A1  - Makariev, M.
A1  - Maneva, G.
A1  - Manganaro, M.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Menzel, U.
A1  - Minev, M.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Moralejo, A.
A1  - Moreno, V.
A1  - Moretti, E.
A1  - Nagayoshi, T.
A1  - Neustroev, V.
A1  - Niedzwiecki, A.
A1  - Nievas Rosillo, M.
A1  - Nigro, C.
A1  - Nilsson, K.
A1  - Ninci, D.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Paiano, S.
A1  - Palacio, J.
A1  - Paneque, D.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Pedaletti, G.
A1  - Peresano, M.
A1  - Perri, L.
A1  - Persic, M.
A1  - Moroni, P. G. Prada
A1  - Prandini, E.
A1  - Puljak, I.
A1  - Garcia, J. R.
A1  - Reichardt, I.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Righi, C.
A1  - Rugliancich, A.
A1  - Saito, T.
A1  - Satalecka, K.
A1  - Schroeder, S.
A1  - Schweizer, T.
A1  - Shore, S. N.
A1  - Sitarek, J.
A1  - Snidaric, I.
A1  - Sobczynska, D.
A1  - Stamerra, A.
A1  - Strzys, M.
A1  - Suric, T.
A1  - Takalo, L.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Teshima, M.
A1  - Torres-Alba, N.
A1  - Treves, A.
A1  - Tsujimoto, S.
A1  - Vanzo, G.
A1  - Vazquez Acosta, M.
A1  - Vovk, I.
A1  - Ward, J. E.
A1  - Will, M.
A1  - Zaric, D.
A1  - Arbet-Engels, A.
A1  - Baack, D.
A1  - Balbo, M.
A1  - Biland, A.
A1  - Blank, M.
A1  - Bretz, T.
A1  - Bruegge, K.
A1  - Bulinski, M.
A1  - Buss, J.
A1  - Dmytriiev, A.
A1  - Dorner, D.
A1  - Einecke, S.
A1  - Elsaesser, D.
A1  - Herbst, T.
A1  - Hildebrand, D.
A1  - Kortmann, L.
A1  - Linhoff, L.
A1  - Mahlke, M.
A1  - Mannheim, K.
A1  - Mueller, S. A.
A1  - Neise, D.
A1  - Neronov, A.
A1  - Noethe, M.
A1  - Oberkirch, J.
A1  - Paravac, A.
A1  - Rhode, W.
A1  - Schleicher, B.
A1  - Schulz, F.
A1  - Sedlaczek, K.
A1  - Shukla, A.
A1  - Sliusar, V.
A1  - Walter, R.
A1  - Archer, A.
A1  - Benbow, W.
A1  - Bird, R.
A1  - Brose, Robert
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Christiansen, J. L.
A1  - Cui, W.
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Gillanders, G. H.
A1  - Gueta, O.
A1  - Hanna, D.
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Huetten, M.
A1  - Humensky, T. B.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, G.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Petrashyk, A.
A1  - Pichel, A.
A1  - Pohl, Martin
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Rovero, A. C.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Sushch, Iurii
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhel, A.
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Perri, M.
A1  - Verrecchia, F.
A1  - Leto, C.
A1  - Villata, M.
A1  - Raiteri, C. M.
A1  - Jorstad, S. G.
A1  - Larionov, V. M.
A1  - Blinov, D. A.
A1  - Grishina, T. S.
A1  - Kopatskaya, E. N.
A1  - Larionova, E. G.
A1  - Nikiforova, A. A.
A1  - Morozova, D. A.
A1  - Troitskaya, Yu. V.
A1  - Troitsky, I. S.
A1  - Kurtanidze, O. M.
A1  - Nikolashvili, M. G.
A1  - Kurtanidze, S. O.
A1  - Kimeridze, G. N.
A1  - Chigladze, R. A.
A1  - Strigachev, A.
A1  - Sadun, A. C.
T1  - Extreme HBL behavior of Markarian 501 during 2012
JF  - Astronomy and astrophysics : an international weekly journal / European Southern Observatory (ESO)
N2  - Aims. We aim to characterize the multiwavelength emission from Markarian 501 (Mrk 501), quantify the energy-dependent variability, study the potential multiband correlations, and describe the temporal evolution of the broadband emission within leptonic theoretical scenarios. Methods. We organized a multiwavelength campaign to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Results. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of similar to 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was similar to 3 CU, and the peak of the high-energy spectral component was found to be at similar to 2 TeV. Both the X-ray and VHE gamma-ray spectral slopes were measured to be extremely hard, with spectral indices <2 during most of the observing campaign, regardless of the X-ray and VHE flux. This study reports the hardest Mrk 501 VHE spectra measured to date. The fractional variability was found to increase with energy, with the highest variability occurring at VHE. Using the complete data set, we found correlation between the X-ray and VHE bands; however, if the June 9 flare is excluded, the correlation disappears (significance <3 sigma) despite the existence of substantial variability in the X-ray and VHE bands throughout the campaign. Conclusions. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency-peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The data set acquired shows that the broadband spectral energy distribution (SED) of Mrk 501, and its transient evolution, is very complex, requiring, within the framework of synchrotron self-Compton (SSC) models, various emission regions for a satisfactory description. Nevertheless the one-zone SSC scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behavior seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays.
KW  - astroparticle physics
KW  - acceleration of particles
KW  - radiation mechanisms: non-thermal
KW  - BL Lacertae objects: general
KW  - BL Lacertae objects: individual: Mrk501
Y1  - 2018
U6  - https://doi.org/10.1051/0004-6361/201833704
SN  - 1432-0746
VL  - 620
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Ahnen, M. L.
A1  - Ansoldi, S.
A1  - Antonelli, L. A.
A1  - Antoranz, P.
A1  - Babic, A.
A1  - Banerjee, B.
A1  - Bangale, P.
A1  - de Almeida, U. Barres
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Bernardini, E.
A1  - Berti, A.
A1  - Biasuzzi, B.
A1  - Biland, A.
A1  - Blanch, O.
A1  - Bonnefoy, S.
A1  - Bonnoli, G.
A1  - Borracci, F.
A1  - Bretz, T.
A1  - Buson, S.
A1  - Carosi, A.
A1  - Chatterjee, A.
A1  - Clavero, R.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Da Vela, P.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Lotto, B.
A1  - Wilhelmi, E. de Ona
A1  - Di Pierro, F.
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Dorner, D.
A1  - Doro, M.
A1  - Einecke, S.
A1  - Glawion, D. Eisenacher
A1  - Elsaesser, D.
A1  - Engelkemeier, M.
A1  - Ramazani, V. Fallah
A1  - Fernandez-Barral, A.
A1  - Fidalgo, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Frantzen, K.
A1  - Fruck, C.
A1  - Galindo, D.
A1  - Lopez, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Terrats, D. Garrido
A1  - Gaug, M.
A1  - Giammaria, P.
A1  - Godinovic, N.
A1  - Gonzalez Munoz, A.
A1  - Gora, D.
A1  - Guberman, D.
A1  - Hadasch, D.
A1  - Hahn, A.
A1  - Hanabata, Y.
A1  - Hayashida, M.
A1  - Herrera, J.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Hughes, G.
A1  - Idec, W.
A1  - Kodani, K.
A1  - Konno, Y.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - La Barbera, A.
A1  - Lelas, D.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Longo, F.
A1  - Lopez, M.
A1  - Lopez-Coto, R.
A1  - Majumdar, P.
A1  - Makariev, M.
A1  - Mallot, K.
A1  - Maneva, G.
A1  - Manganaro, M.
A1  - Mannheim, K.
A1  - Maraschi, L.
A1  - Marcote, B.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Menzel, U.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Moralejo, A.
A1  - Moretti, E.
A1  - Nakajima, D.
A1  - Neustroev, V.
A1  - Niedzwiecki, A.
A1  - Rosillo, M. Nievas
A1  - Nilsson, K.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Overkemping, A.
A1  - Paiano, S.
A1  - Palacio, J.
A1  - Palatiello, M.
A1  - Paneque, D.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Paredes-Fortuny, X.
A1  - Pedaletti, G.
A1  - Peresano, M.
A1  - Perri, L.
A1  - Persic, M.
A1  - Poutanen, J.
A1  - Moroni, P. G. Prada
A1  - Prandini, E.
A1  - Puljak, I.
A1  - Reichardt, I.
A1  - Rhode, W.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Rodriguez Garcia, J.
A1  - Saito, T.
A1  - Satalecka, K.
A1  - Schroder, S.
A1  - Schultz, C.
A1  - Schweizer, T.
A1  - Shore, S. N.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Snidaric, I.
A1  - Sobczynska, D.
A1  - Stamerra, A.
A1  - Steinbring, T.
A1  - Strzys, M.
A1  - Suric, T.
A1  - Takalo, L.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Tescaro, D.
A1  - Teshima, M.
A1  - Thaele, J.
A1  - Torres, D. F.
A1  - Toyama, T.
A1  - Treves, A.
A1  - Vanzo, G.
A1  - Verguilov, V.
A1  - Vovk, I.
A1  - Ward, J. E.
A1  - Will, M.
A1  - Wu, M. H.
A1  - Zanin, R.
A1  - Abeysekara, A. U.
A1  - Archambault, S.
A1  - Archer, A.
A1  - Benbow, W.
A1  - Bird, R.
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dickinson, H. J.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Fleischhack, H.
A1  - Flinders, A.
A1  - Fortson, L.
A1  - Gillanders, G. H.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Huetten, M.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nieto, D.
A1  - Ong, R. A.
A1  - Otte, N.
A1  - Park, N.
A1  - Perkins, J.
A1  - Pichel, A.
A1  - Pohl, M.
A1  - Popkow, A.
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Rovero, A. C.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Telezhinsky, Igor O.
A1  - Tucci, J. V.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Zitzer, B.
A1  - Razzaque, S.
A1  - Villata, M.
A1  - Raiteri, C. M.
A1  - Aller, H. D.
A1  - Aller, M. F.
A1  - Larionov, V. M.
A1  - Arkharov, A. A.
A1  - Blinov, D. A.
A1  - Efimova, N. V.
A1  - Grishina, T. S.
A1  - Hagen-Thorn, V. A.
A1  - Kopatskaya, E. N.
A1  - Larionova, L. V.
A1  - Larionova, E. G.
A1  - Morozova, D. A.
A1  - Troitsky, I. S.
A1  - Ligustri, R.
A1  - Calcidese, P.
A1  - Berdyugin, A.
A1  - Kurtanidze, O. M.
A1  - Nikolashvili, M. G.
A1  - Kimeridze, G. N.
A1  - Sigua, L. A.
A1  - Kurtanidze, S. O.
A1  - Chigladze, R. A.
A1  - Chen, W. P.
A1  - Koptelova, E.
A1  - Sakamoto, T.
A1  - Sadun, A. C.
A1  - Moody, J. W.
A1  - Pace, C.
A1  - Pearson, R.
A1  - Yatsu, Y.
A1  - Mori, Y.
A1  - Carraminyana, A.
A1  - Carrasco, L.
A1  - de la Fuente, E.
A1  - Norris, J. P.
A1  - Smith, P. S.
A1  - Wehrle, A.
A1  - Gurwell, M. A.
A1  - Zook, A.
A1  - Pagani, C.
A1  - Perri, M.
A1  - Capalbi, M.
A1  - Cesarini, A.
A1  - Krimm, H. A.
A1  - Kovalev, Y. Y.
A1  - Kovalev, Yu. A.
A1  - Ros, E.
A1  - Pushkarev, A. B.
A1  - Lister, M. L.
A1  - Sokolovsky, K. V.
A1  - Kadler, M.
A1  - Piner, G.
A1  - Lahteenmaki, A.
A1  - Tornikoski, M.
A1  - Angelakis, E.
A1  - Krichbaum, T. P.
A1  - Nestoras, I.
A1  - Fuhrmann, L.
A1  - Zensus, J. A.
A1  - Cassaro, P.
A1  - Orlati, A.
A1  - Maccaferri, G.
A1  - Leto, P.
A1  - Giroletti, M.
A1  - Richards, J. L.
A1  - Max-Moerbeck, W.
A1  - Readhead, A. C. S.
T1  - Multiband variability studies and novel broadband SED modeling of Mrk 501 in 2009
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Aims. We present an extensive study of the BL Lac object Mrk 501 based on a data set collected during the multi-instrument campaign spanning from 2009 March 15 to 2009 August 1, which includes, among other instruments, MAGIC, VERITAS, Whipple 10 m, and Fermi-LAT to cover the gamma-ray range from 0.1 GeV to 20 TeV; RXTE and Swift to cover wavelengths from UV to hard X-rays; and GASP-WEBT, which provides coverage of radio and optical wavelengths. Optical polarization measurements were provided for a fraction of the campaign by the Steward and St. Petersburg observatories. We evaluate the variability of the source and interband correlations, the gamma-ray flaring activity occurring in May 2009, and interpret the results within two synchrotron self-Compton (SSC) scenarios. Methods. The multiband variability observed during the full campaign is addressed in terms of the fractional variability, and the possible correlations are studied by calculating the discrete correlation function for each pair of energy bands where the significance was evaluated with dedicated Monte Carlo simulations. The space of SSC model parameters is probed following a dedicated grid-scan strategy, allowing for a wide range of models to be tested and offering a study of the degeneracy of model-to-data agreement in the individual model parameters, hence providing a less biased interpretation than the "single-curve SSC model adjustment" typically reported in the literature. Results. We find an increase in the fractional variability with energy, while no significant interband correlations of flux changes are found on the basis of the acquired data set. The SSC model grid-scan shows that the flaring activity around May 22 cannot be modeled adequately with a one-zone SSC scenario (using an electron energy distribution with two breaks), while it can be suitably described within a two (independent) zone SSC scenario. Here, one zone is responsible for the quiescent emission from the averaged 4.5-month observing period, while the other one, which is spatially separated from the first, dominates the flaring emission occurring at X-rays and very-high-energy (> 100 GeV, VHE) gamma-rays. The flaring activity from May 1, which coincides with a rotation of the electric vector polarization angle (EVPA), cannot be satisfactorily reproduced by either a one-zone or a two-independent-zone SSC model, yet this is partially affected by the lack of strictly simultaneous observations and the presence of large flux changes on sub-hour timescales (detected at VHE gamma rays). Conclusions. The higher variability in the VHE emission and lack of correlation with the X-ray emission indicate that, at least during the 4.5-month observing campaign in 2009, the highest energy (and most variable) electrons that are responsible for the VHE gamma rays do not make a dominant contribution to the similar to 1 keV emission. Alternatively, there could be a very variable component contributing to the VHE gamma-ray emission in addition to that coming from the SSC scenario. The studies with our dedicated SSC grid-scan show that there is some degeneracy in both the one-zone and the two-zone SSC scenarios probed, with several combinations of model parameters yielding a similar model-to-data agreement, and some parameters better constrained than others. The observed gamma-ray flaring activity, with the EVPA rotation coincident with the first gamma-ray flare, resembles those reported previously for low frequency peaked blazars, hence suggesting that there are many similarities in the flaring mechanisms of blazars with different jet properties.
KW  - BL Lacertae objects: individual: Markarian 501
KW  - methods: data analysis
Y1  - 2017
U6  - https://doi.org/10.1051/0004-6361/201629540
SN  - 1432-0746
VL  - 603
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Ahmed, Muhammad N.
A1  - Reyna-Gonzalez, Emmanuel
A1  - Schmid, Bianca
A1  - Wiebach, Vincent
A1  - Suessmuth, Roderich D.
A1  - Dittmann, Elke
A1  - Fewer, David P.
T1  - Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors
JF  - ACS chemical biology
N2  - Natural products and their semisynthetic derivatives are an important source of drugs for the pharmaceutical industry. Bacteria are prolific producers of natural products and encode a vast diversity of natural product biosynthetic gene clusters. However, much of this diversity is inaccessible to natural product discovery. Here, we use a combination of phylogenomic analysis of the microviridin biosynthetic pathway and chemo-enzymatic synthesis of bioinformatically predicted microviridins to yield new protease inhibitors. Phylogenomic analysis demonstrated that microviridin biosynthetic gene clusters occur across the bacterial domain and encode three distinct subtypes of precursor peptides. Our analysis shed light on the evolution of microviridin biosynthesis and enabled prioritization of their chemo-enzymatic production. Targeted one-pot synthesis of four microviridins encoded by the cyanobacterium Cyanothece sp. PCC 7822 identified a set of novel and potent serine protease inhibitors, the most active of which had an IC50 value of 21.5 nM. This study advances the genome mining techniques available for natural product discovery and obviates the need to culture bacteria.
Y1  - 2017
U6  - https://doi.org/10.1021/acschembio.7b00124
SN  - 1554-8929
SN  - 1554-8937
VL  - 12
SP  - 1538
EP  - 1546
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Ahmadi, Hamid
A1  - Herat, Nehara
A1  - Alizadeh, Shahab
A1  - Button, Duane C.
A1  - Granacher, Urs
A1  - Behm, David G.
T1  - Effect of an inverted seated position with upper arm blood flow restriction on measures of elbow flexors neuromuscular performance
JF  - PLOS ONE / Public Library of Science
N2  - Purpose
The objective of the investigation was to determine the concomitant effects of upper arm blood flow restriction (BFR) and inversion on elbow flexors neuromuscular responses. 

Methods 
Randomly allocated, 13 volunteers performed four conditions in a within-subject design: rest (control, 1-min upright position without BFR), control (1-min upright with BFR), 1-min inverted (without BFR), and 1-min inverted with BFR. Evoked and voluntary contractile properties, before, during and after a 30-s maximum voluntary contraction (MVC) exercise intervention were examined as well as pain scale. 

Results
Inversion induced significant pre-exercise intervention decreases in elbow flexors MVC (21.1%, Z2p = 0.48, p = 0.02) and resting evoked twitch forces (29.4%, Z2p = 0.34, p = 0.03). The 30-s MVC induced significantly greater pre- to post-test decreases in potentiated twitch force (Z2p = 0.61, p = 0.0009) during inversion (75%) than upright (65.3%) conditions. Overall, BFR decreased MVC force 4.8% (Z2p = 0.37, p = 0.05). For upright position, BFR induced 21.0% reductions in M-wave amplitude (Z2p = 0.44, p = 0.04). There were no significant differences for electromyographic activity or voluntary activation as measured with the interpolated twitch technique. For all conditions, there was a significant increase in pain scale between the 40-60 s intervals and post-30-s MVC (upright< inversion, and without BFR< BFR). 

Conclusion
The concomitant application of inversion with elbow flexors BFR only amplified neuromuscular performance impairments to a small degree. Individuals who execute forceful contractions when inverted or with BFR should be cognizant that force output may be impaired.
Y1  - 2021
U6  - https://doi.org/10.1371/journal.pone.0245311
SN  - 1932-6203
VL  - 16
IS  - 5
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Ahmad, Nadeem
A1  - Shoaib, Umar
A1  - Prinetto, Paolo
T1  - Usability of Online Assistance From Semiliterate Users' Perspective
JF  - International journal of human computer interaction
Y1  - 2015
U6  - https://doi.org/10.1080/10447318.2014.925772
SN  - 1044-7318
SN  - 1532-7590
VL  - 31
IS  - 1
SP  - 55
EP  - 64
PB  - Taylor & Francis Group
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Ahlgrimm, Helga
T1  - Innovative Elemente der Entwicklung neuer Rahmenpläne im Land Thüringen
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Ahlgrimm, Frederik
A1  - Heck, Sebastian
T1  - Internationalisierung der Lehrerbildung an der Universität Potsdam
BT  - Entwicklungen in den Jahren 2015 bis 2018
JF  - Potsdamer Beiträge zur Lehrerbildung und Bildungsforschung
N2  - In den vergangenen Jahren wurde immer wieder gefordert, dass die Lehrerbildung an deutschen Hochschulen stärker internationalisiert werden solle. Die Universität Potsdam hat sich als Teil ihrer Internationalisierungsstrategie zur Aufgabe gemacht, die internationale Dimension ihres renommierten Modells der Lehrerbildung zu fördern. In diesem Beitrag wird dargestellt, wie im Rahmen des Teilprojektes Internationalisierung der QLB – ausgehend vom politisch-gesellschaftlichen Kontext und dem Status Quo im Bereich der Lehrerbildung – zunächst ein internes Verständnis von Internationalisierung entwickelt und darauf aufbauend eine Strategie mit konkreten Maßnahmen abgeleitet wurde. Der Implementierungsprozess führte zu Vernetzungen sowohl innerhalb der Universität als auch mit externen und internationalen Akteuren im Bildungswesen. Die vorgestellten Maßnahmen können auch für andere Hochschulen von Interesse sein.
N2  - Over the past few years there have been increasing calls for teacher training in German universities to become more international. As part of its internationalization strategy, the University of Potsdam has tasked itself with enhancing the international aspects of its renowned teacher-training model. In this paper, we outline the development of an internal internationalization concept and development strategy built upon this concept, developed as part of the scheme “Qualitätsoffensive Lehrerbildung” (Teacher Training Quality Initiative). The implementation process has led to networking opportunities both within the university as well as with external and international parties working in education. The measures employed in the strategy may also be of interested to other universities.
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-420376
SN  - 978-3-86956-442-5
SN  - 2626-3556
SN  - 2626-4722
SP  - 257
EP  - 269
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Ahlers, Volker
A1  - Zillmer, Rüdiger
A1  - Pikovskij, Arkadij
T1  - Lyapunov exponents in disordered chaotic systems : avoided crossing and level statistics
N2  - The behavior of the Lyapunov exponents (LEs) of a disordered system consisting of mutually coupled chaotic maps with different parameters is studied. The LEs are demonstrated to exhibit avoided crossing and level repulsion, qualitatively similar to the behavior of energy levels in quantum chaos. Recent results for the coupling dependence of the LEs of two coupled chaotic systems are used to explain the phenomenon and to derive an approximate expression for the distribution functions of LE spacings. The depletion of the level spacing distribution is shown to be exponentially strong at small values. The results are interpreted in terms of the random matrix theory.
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Ahlers, Volker
A1  - Zillmer, Rüdiger
A1  - Pikovskij, Arkadij
T1  - Statistical theory for the coupling sensitivity of chaos
Y1  - 2000
SN  - 1-563-96915-7
ER  - 
TY  - JOUR
A1  - Ahlers, Volker
A1  - Pikovskij, Arkadij
T1  - Critical Properties of the Synchronization Transition in Space-Time Chaos
N2  - We study two coupled spatially extended dynamical systems which exhibit space-time chaos. The transition to the synchronized state is treated as a nonequilibrium phase transition, where the average synchronization error is the order parameter. The transition in one-dimensional systems is found to be generically in the universality class of the Kardar- Parisi-Zhang equation with a growth-limiting term ("bounded KPZ"). For systems with very strong nonlinearities in the local dynamics, however, the transition is found to be in the universality class of directed percolation.
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Ahlberg, Sebastian
A1  - Rancan, Fiorenza
A1  - Epple, Matthias
A1  - Loza, Kateryna
A1  - Höppe, David
A1  - Lademann, Jürgen
A1  - Vogt, Annika
A1  - Kleuser, Burkhard
A1  - Gerecke, Christian
A1  - Meinke, Martina C.
T1  - Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxidant status of human keratinocytes and fibroblasts
JF  - Methods : focusing on rapidly developing techniques
KW  - Oxidative stress
KW  - Dichlorofluorescein assay
KW  - Electron paramagnetic resonance spectroscopy
KW  - HaCaT cells
KW  - Glutathione
KW  - Free radicals
Y1  - 2016
U6  - https://doi.org/10.1016/j.ymeth.2016.05.015
SN  - 1046-2023
SN  - 1095-9130
VL  - 109
SP  - 55
EP  - 63
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Aguilera-Dena, David R.
A1  - Langer, Norbert
A1  - Antoniadis, John
A1  - Pauli, Daniel
A1  - Dessart, Luc
A1  - Vigna-Gómez, Alejandro
A1  - Gräfener, Götz
A1  - Yoon, Sung-Chul
T1  - Stripped-envelope stars in different metallicity environments: I. Evolutionary phases, classification, and populations
JF  - Astronomy and astrophysics
N2  - Massive stars that become stripped of their hydrogen envelope through binary interaction or winds can be observed either as Wolf-Rayet stars, if they have optically thick winds, or as transparent-wind stripped-envelope stars. We approximate their evolution through evolutionary models of single helium stars, and compute detailed model grids in the initial mass range 1.5-70 M. for metallicities between 0.01 and 0.04, from core helium ignition until core collapse. Throughout their lifetimes some stellar models expose the ash of helium burning. We propose that models that have nitrogen-rich envelopes are candidate WN stars, while models with a carbon-rich surface are candidate WC stars during core helium burning, and WO stars afterwards. We measure the metallicity dependence of the total lifetimes of our models and the duration of their evolutionary phases. We propose an analytic estimate of the wind's optical depth to distinguish models of Wolf-Rayet stars from transparent-wind stripped-envelope stars, and find that the luminosity ranges at which WN-, WC-, and WO-type stars can exist is a strong function of metallicity. We find that all carbon-rich models produced in our grids have optically thick winds and match the luminosity distribution of observed populations. We construct population models and predict the numbers of transparent-wind stripped-envelope stars and Wolf-Rayet stars, and derive their number ratios at different metallicities. We find that as metallicity increases, the number of transparent-wind stripped-envelope stars decreases and the number of Wolf-Rayet stars increases. At high metallicities WC- and WO-type stars become more common. We apply our population models to nearby galaxies, and find that populations are more sensitive to the transition luminosity between Wolf-Rayet stars and transparent-wind helium stars than to the metallicity-dependent mass loss rates.
KW  - stars: massive
KW  - stars: Wolf-Rayet
KW  - stars: winds, outflows
KW  - binaries: general
KW  - supernovae: general
Y1  - 2022
U6  - https://doi.org/10.1051/0004-6361/202142895
SN  - 0004-6361
SN  - 1432-0746
VL  - 661
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Aguado, Felicidad
A1  - Cabalar, Pedro
A1  - Fandiño, Jorge
A1  - Pearce, David
A1  - Perez, Gilberto
A1  - Vidal-Peracho, Concepcion
T1  - Revisiting Explicit Negation in Answer Set Programming
JF  - Theory and practice of logic programming
KW  - Answer set programming
KW  - Non-monotonic reasoning
KW  - Equilibrium logic
KW  - Explicit negation
Y1  - 2019
U6  - https://doi.org/10.1017/S1471068419000267
SN  - 1471-0684
SN  - 1475-3081
VL  - 19
IS  - 5-6
SP  - 908
EP  - 924
PB  - Cambridge Univ. Press
CY  - New York
ER  - 
TY  - JOUR
A1  - Aguado, Felicidad
A1  - Cabalar, Pedro
A1  - Fandiño, Jorge
A1  - Pearce, David
A1  - Perez, Gilberto
A1  - Vidal, Concepcion
T1  - Forgetting auxiliary atoms in forks
JF  - Artificial intelligence
N2  - In this work we tackle the problem of checking strong equivalence of logic programs that may contain local auxiliary atoms, to be removed from their stable models and to be forbidden in any external context. We call this property projective strong equivalence (PSE). It has been recently proved that not any logic program containing auxiliary atoms can be reformulated, under PSE, as another logic program or formula without them – this is known as strongly persistent forgetting. In this paper, we introduce a conservative extension of Equilibrium Logic and its monotonic basis, the logic of Here-and-There, in which we deal with a new connective ‘|’ we call fork. We provide a semantic characterisation of PSE for forks and use it to show that, in this extension, it is always possible to forget auxiliary atoms under strong persistence. We further define when the obtained fork is representable as a regular formula.
KW  - Answer set programming
KW  - Non-monotonic reasoning
KW  - Equilibrium logic
KW  - Denotational semantics
KW  - Forgetting
KW  - Strong equivalence
Y1  - 2019
U6  - https://doi.org/10.1016/j.artint.2019.07.005
SN  - 0004-3702
SN  - 1872-7921
VL  - 275
SP  - 575
EP  - 601
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Agthe, Maria
A1  - Kayser, Daniela Niesta
A1  - Schwarz, Sascha
A1  - Maner, Jon K.
T1  - Antecedents of the red-romance effect
BT  - men's attractiveness and women's fertility
JF  - PLOS ONE / Public Library of Science
N2  - The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.
Y1  - 2023
U6  - https://doi.org/10.1371/journal.pone.0284035
SN  - 1932-6203
VL  - 18
IS  - 4
PB  - PLOS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Agrofylax, Sotirios
A1  - Stockhorst, Stefanie
T1  - Sapere aude!
BT  - Praxisformen der Aufklärung im Spiegel editorischer Abgesänge auf Zeitschriftenprojekte
JF  - Lessing Yearbook/Jahrbuch
Y1  - 2022
SN  - 978-3-8353-4936-0
SN  - 978-3-8353-5289-6
U6  - https://doi.org/10.5771/9783835349360-15
VL  - XLIX
SP  - 15
EP  - 37
PB  - Wallstein
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Agne, Stefanie
A1  - Preick, Michaela
A1  - Straube, Nicolas
A1  - Hofreiter, Michael
T1  - Simultaneous Barcode Sequencing of Diverse Museum Collection Specimens Using a Mixed RNA Bait Set
JF  - Frontiers in Ecology and Evolution
N2  - A growing number of publications presenting results from sequencing natural history collection specimens reflect the importance of DNA sequence information from such samples. Ancient DNA extraction and library preparation methods in combination with target gene capture are a way of unlocking archival DNA, including from formalin-fixed wet-collection material. Here we report on an experiment, in which we used an RNA bait set containing baits from a wide taxonomic range of species for DNA hybridisation capture of nuclear and mitochondrial targets for analysing natural history collection specimens. The bait set used consists of 2,492 mitochondrial and 530 nuclear RNA baits and comprises specific barcode loci of diverse animal groups including both invertebrates and vertebrates. The baits allowed to capture DNA sequence information of target barcode loci from 84% of the 37 samples tested, with nuclear markers being captured more frequently and consensus sequences of these being more complete compared to mitochondrial markers. Samples from dry material had a higher rate of success than wet-collection specimens, although target sequence information could be captured from 50% of formalin-fixed samples. Our study illustrates how efforts to obtain barcode sequence information from natural history collection specimens may be combined and are a way of implementing barcoding inventories of scientific collection material.
KW  - target capture
KW  - type specimens
KW  - molecular species identification
KW  - museum specimens
KW  - cross-species capture
Y1  - 2022
U6  - https://doi.org/10.3389/fevo.2022.909846
SN  - 2296-701X
VL  - 10
PB  - Frontiers Media S.A.
CY  - Lausanne, Schweiz
ER  - 
TY  - JOUR
A1  - Agne, Stefanie
A1  - Naylor, Gavin J. P.
A1  - Preick, Michaela
A1  - Yang, Lei
A1  - Thiel, Ralf
A1  - Weigmann, Simon
A1  - Paijmans, Johanna L. A.
A1  - Barlow, Axel
A1  - Hofreiter, Michael
A1  - Straube, Nicolas
T1  - Taxonomic identification of two poorly known lantern shark species based on mitochondrial DNA from wet-collection paratypes
JF  - Frontiers in Ecology and Evolution
N2  - Etmopteridae (lantern sharks) is the most species-rich family of sharks, comprising more than 50 species. 
Many species are described from few individuals, and re-collection of specimens is often hindered by the remoteness of their sampling sites. 
For taxonomic studies, comparative morphological analysis of type specimens housed in natural history collections has been the main source of evidence. 
In contrast, DNA sequence information has rarely been used. 
Most lantern shark collection specimens, including the types, were formalin fixed before long-term storage in ethanol solutions. 
The DNA damage caused by both fixation and preservation of specimens has excluded these specimens from DNA sequence-based phylogenetic analyses so far. 

However, recent advances in the field of ancient DNA have allowed recovery of wet-collection specimen DNA sequence data. 
Here we analyse archival mitochondrial DNA sequences, obtained using ancient DNA approaches, of two wet-collection lantern shark paratype specimens, namely Etmopterus litvinovi and E. pycnolepis, for which the type series represent the only known individuals. 
Target capture of mitochondrial markers from single-stranded DNA libraries allows for phylogenetic placement of both species. 

Our results suggest synonymy of E. benchleyi with E. litvinovi but support the species status of E. pycnolepis. This revised taxonomy is helpful for future conservation and management efforts, as our results indicate a larger distribution range of E. litvinovi. This study further demonstrates the importance of wet-collection type specimens as genetic resource for taxonomic research.
KW  - type specimens
KW  - Etmopterus litvinovi
KW  - Etmopterus pycnolepis
KW  - deep-sea
KW  - sharks
KW  - archival DNA
Y1  - 2022
U6  - https://doi.org/10.3389/fevo.2022.910009
SN  - 2296-701X
VL  - 10
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Agarwal, Saloni
A1  - Warmt, Christian
A1  - Henkel, Jörg
A1  - Schrick, Livia
A1  - Nitsche, Andreas
A1  - Bier, Frank Fabian
T1  - Lateral flow-based nucleic acid detection of SARS-CoV-2 using enzymatic incorporation of biotin-labeled dUTP for POCT use
JF  - Analytical and bioanalytical chemistry : a merger of Fresenius' journal of analytical chemistry, Analusis and Quimica analitica
N2  - The degree of detrimental effects inflicted on mankind by the COVID-19 pandemic increased the need to develop ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable) POCT (point of care testing) to overcome the current and any future pandemics. Much effort in research and development is currently advancing the progress to overcome the diagnostic pressure built up by emerging new pathogens. LAMP (loop-mediated isothermal amplification) is a well-researched isothermal technique for specific nucleic acid amplification which can be combined with a highly sensitive immunochromatographic readout via lateral flow assays (LFA). Here we discuss LAMP-LFA robustness, sensitivity, and specificity for SARS-CoV-2 N-gene detection in cDNA and clinical swab-extracted RNA samples. The LFA readout is designed to produce highly specific results by incorporation of biotin and FITC labels to 11-dUTP and LF (loop forming forward) primer, respectively. The LAMP-LFA assay was established using cDNA for N-gene with an accuracy of 95.65%. To validate the study, 82 SARS-CoV-2-positive RNA samples were tested. Reverse transcriptase (RT)-LAMP-LFA was positive for the RNA samples with an accuracy of 81.66%; SARS-CoV-2 viral RNA was detected by RT-LAMP-LFA for as low as CT-33. Our method reduced the detection time to 15 min and indicates therefore that RT-LAMP in combination with LFA represents a promising nucleic acid biosensing POCT platform that combines with smartphone based semi-quantitative data analysis.
KW  - Point of care testing (POCT)
KW  - Lateral flow assay (LFA)
KW  - COVID-19
KW  - Reverse transcription loop-mediated isothermal amplification (RT-LAMP);
KW  - SARS-CoV-2 N-gene
Y1  - 2022
U6  - https://doi.org/10.1007/s00216-022-03880-4
SN  - 1618-2642
SN  - 1618-2650
VL  - 414
IS  - 10
SP  - 3177
EP  - 3186
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Agarwal, Saloni
A1  - Hamidizadeh, Mojdeh
A1  - Bier, Frank Fabian
T1  - Detection of reverse transcriptase LAMP-amplified nucleic acid from oropharyngeal viral swab samples using biotinylated DNA probes through a lateral flow assay
JF  - Biosensors : open access journal
N2  - This study focuses on three key aspects: (a) crude throat swab samples in a viral transport medium (VTM) as templates for RT-LAMP reactions; (b) a biotinylated DNA probe with enhanced specificity for LFA readouts; and (c) a digital semi-quantification of LFA readouts. Throat swab samples from SARS-CoV-2 positive and negative patients were used in their crude (no cleaning or pre-treatment) forms for the RT-LAMP reaction. The samples were heat-inactivated but not treated for any kind of nucleic acid extraction or purification. The RT-LAMP (20 min processing time) product was read out by an LFA approach using two labels: FITC and biotin. FITC was enzymatically incorporated into the RT-LAMP amplicon with the LF-LAMP primer, and biotin was introduced using biotinylated DNA probes, specifically for the amplicon region after RT-LAMP amplification. This assay setup with biotinylated DNA probe-based LFA readouts of the RT-LAMP amplicon was 98.11% sensitive and 96.15% specific. The LFA result was further analysed by a smartphone-based IVD device, wherein the T-line intensity was recorded. The LFA T-line intensity was then correlated with the qRT-PCR Ct value of the positive swab samples. A digital semi-quantification of RT-LAMP-LFA was reported with a correlation coefficient of R2 = 0.702. The overall RT-LAMP-LFA assay time was recorded to be 35 min with a LoD of three RNA copies/µL (Ct-33). With these three advancements, the nucleic acid testing-point of care technique (NAT-POCT) is exemplified as a versatile biosensor platform with great potential and applicability for the detection of pathogens without the need for sample storage, transportation, or pre-processing.
KW  - RT-LAMP
KW  - LFA
KW  - NAAT-LFA
KW  - semi-quantitative
KW  - surveillance-based diagnostics
Y1  - 2023
U6  - https://doi.org/10.3390/bios13110988
SN  - 2079-6374
VL  - 13
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Marwan, Norbert
A1  - Maheswaran, Rathinasamy
A1  - Öztürk, Ugur
A1  - Kurths, Jürgen
A1  - Merz, Bruno
T1  - Optimal design of hydrometric station networks based on complex network analysis
JF  - Hydrology and Earth System Sciences
N2  - Hydrometric networks play a vital role in providing information for decision-making in water resource management. They should be set up optimally to provide as much information as possible that is as accurate as possible and, at the same time, be cost-effective. Although the design of hydrometric networks is a well-identified problem in hydrometeorology and has received considerable attention, there is still scope for further advancement. In this study, we use complex network analysis, defined as a collection of nodes interconnected by links, to propose a new measure that identifies critical nodes of station networks. The approach can support the design and redesign of hydrometric station networks. The science of complex networks is a relatively young field and has gained significant momentum over the last few years in different areas such as brain networks, social networks, technological networks, or climate networks. The identification of influential nodes in complex networks is an important field of research. We propose a new node-ranking measure – the weighted degree–betweenness (WDB) measure – to evaluate the importance of nodes in a network. It is compared to previously proposed measures used on synthetic sample networks and then applied to a real-world rain gauge network comprising 1229 stations across Germany to demonstrate its applicability. The proposed measure is evaluated using the decline rate of the network efficiency and the kriging error. The results suggest that WDB effectively quantifies the importance of rain gauges, although the benefits of the method need to be investigated in more detail.
KW  - identifying influential nodes
KW  - climate networks
KW  - rainfall
KW  - streamflow
KW  - synchronization
KW  - precipitation
KW  - classification
KW  - events
Y1  - 2020
U6  - https://doi.org/10.5194/hess-24-2235-2020
SN  - 1027-5606
SN  - 1607-7938
VL  - 24
IS  - 5
SP  - 2235
EP  - 2251
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Marwan, Norbert
A1  - Maheswaran, Rathinasamy
A1  - Merz, Bruno
A1  - Kurths, Jürgen
T1  - Multi-scale event synchronization analysis for unravelling climate processes: a wavelet-based approach
JF  - Nonlinear processes in geophysics
N2  - The temporal dynamics of climate processes are spread across different timescales and, as such, the study of these processes at only one selected timescale might not reveal the complete mechanisms and interactions within and between the (sub-) processes. To capture the non-linear interactions between climatic events, the method of event synchronization has found increasing attention recently. The main drawback with the present estimation of event synchronization is its restriction to analysing the time series at one reference timescale only. The study of event synchronization at multiple scales would be of great interest to comprehend the dynamics of the investigated climate processes. In this paper, the wavelet-based multi-scale event synchronization (MSES) method is proposed by combining the wavelet transform and event synchronization. Wavelets are used extensively to comprehend multi-scale processes and the dynamics of processes across various timescales. The proposed method allows the study of spatio-temporal patterns across different timescales. The method is tested on synthetic and real-world time series in order to check its replicability and applicability. The results indicate that MSES is able to capture relationships that exist between processes at different timescales.
Y1  - 2017
U6  - https://doi.org/10.5194/npg-24-599-2017
SN  - 1023-5809
VL  - 24
SP  - 599
EP  - 611
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Marwan, Norbert
A1  - Maheswaran, Rathinasamy
A1  - Merz, Bruno
A1  - Kurths, Jürgen
T1  - Quantifying the roles of single stations within homogeneous regions using complex network analysis
JF  - Journal of hydrology
N2  - Regionalization and pooling stations to form homogeneous regions or communities are essential for reliable parameter transfer, prediction in ungauged basins, and estimation of missing information. Over the years, several clustering methods have been proposed for regional analysis. Most of these methods are able to quantify the study region in terms of homogeneity but fail to provide microscopic information about the interaction between communities, as well as about each station within the communities. We propose a complex network-based approach to extract this valuable information and demonstrate the potential of our approach using a rainfall network constructed from the Indian gridded daily precipitation data. The communities were identified using the network-theoretical community detection algorithm for maximizing the modularity. Further, the grid points (nodes) were classified into universal roles according to their pattern of within- and between-community connections. The method thus yields zoomed-in details of individual rainfall grids within each community.
KW  - Complex network
KW  - Event synchronization
KW  - Rainfall network
KW  - Z-P approach
Y1  - 2018
U6  - https://doi.org/10.1016/j.jhydrol.2018.06.050
SN  - 0022-1694
SN  - 1879-2707
VL  - 563
SP  - 802
EP  - 810
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Maheswaran, Rathinasamy
A1  - Marwan, Norbert
A1  - Caesar, Levke
A1  - Kurths, Jürgen
T1  - Wavelet-based multiscale similarity measure for complex networks
JF  - The European physical journal : B, Condensed matter and complex systems
N2  - In recent years, complex network analysis facilitated the identification of universal and unexpected patterns in complex climate systems. However, the analysis and representation of a multiscale complex relationship that exists in the global climate system are limited. A logical first step in addressing this issue is to construct multiple networks over different timescales. Therefore, we propose to apply the wavelet multiscale correlation (WMC) similarity measure, which is a combination of two state-of-the-art methods, viz. wavelet and Pearson’s correlation, for investigating multiscale processes through complex networks. Firstly we decompose the data over different timescales using the wavelet approach and subsequently construct a corresponding network by Pearson’s correlation. The proposed approach is illustrated and tested on two synthetics and one real-world example. The first synthetic case study shows the efficacy of the proposed approach to unravel scale-specific connections, which are often undiscovered at a single scale. The second synthetic case study illustrates that by dividing and constructing a separate network for each time window we can detect significant changes in the signal structure. The real-world example investigates the behavior of the global sea surface temperature (SST) network at different timescales. Intriguingly, we notice that spatial dependent structure in SST evolves temporally. Overall, the proposed measure has an immense potential to provide essential insights on understanding and extending complex multivariate process studies at multiple scales.
KW  - Statistical and Nonlinear Physics
Y1  - 2018
U6  - https://doi.org/10.1140/epjb/e2018-90460-6
SN  - 1434-6028
SN  - 1434-6036
VL  - 91
IS  - 11
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Maheswaran, Rathinasamy
A1  - Kurths, Jürgen
A1  - Khosa, R.
T1  - Wavelet Spectrum and Self-Organizing Maps-Based Approach for Hydrologic Regionalization -a Case Study in the Western United States
JF  - Water Resources Management
N2  - Hydrologic regionalization deals with the investigation of homogeneity in watersheds and provides a classification of watersheds for regional analysis. The classification thus obtained can be used as a basis for mapping data from gauged to ungauged sites and can improve extreme event prediction. This paper proposes a wavelet power spectrum (WPS) coupled with the self-organizing map method for clustering hydrologic catchments. The application of this technique is implemented for gauged catchments. As a test case study, monthly streamflow records observed at 117 selected catchments throughout the western United States from 1951 through 2002. Further, based on WPS of each station, catchments are classified into homogeneous clusters, which provides a representative WPS pattern for the streamflow stations in each cluster.
KW  - Wavelet power spectrum
KW  - Regionalization
KW  - Ungauged catchments
KW  - K-means technique
KW  - Self-organizing map
Y1  - 2016
U6  - https://doi.org/10.1007/s11269-016-1428-1
SN  - 0920-4741
SN  - 1573-1650
VL  - 30
SP  - 4399
EP  - 4413
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Guntu, Ravikumar
A1  - Banerjee, Abhirup
A1  - Gadhawe, Mayuri Ashokrao
A1  - Marwan, Norbert
T1  - A complex network approach to study the extreme precipitation patterns in a river basin
JF  - Chaos : an interdisciplinary journal of nonlinear science
N2  - The quantification of spatial propagation of extreme precipitation events is vital in water resources planning and disaster mitigation. However, quantifying these extreme events has always been challenging as many traditional methods are insufficient to capture the nonlinear interrelationships between extreme event time series. Therefore, it is crucial to develop suitable methods for analyzing the dynamics of extreme events over a river basin with a diverse climate and complicated topography. Over the last decade, complex network analysis emerged as a powerful tool to study the intricate spatiotemporal relationship between many variables in a compact way. In this study, we employ two nonlinear concepts of event synchronization and edit distance to investigate the extreme precipitation pattern in the Ganga river basin. We use the network degree to understand the spatial synchronization pattern of extreme rainfall and identify essential sites in the river basin with respect to potential prediction skills. The study also attempts to quantify the influence of precipitation seasonality and topography on extreme events. The findings of the study reveal that (1) the network degree is decreased in the southwest to northwest direction, (2) the timing of 50th percentile precipitation within a year influences the spatial distribution of degree, (3) the timing is inversely related to elevation, and (4) the lower elevation greatly influences connectivity of the sites. The study highlights that edit distance could be a promising alternative to analyze event-like data by incorporating event time and amplitude and constructing complex networks of climate extremes.
Y1  - 2022
U6  - https://doi.org/10.1063/5.0072520
SN  - 1054-1500
SN  - 1089-7682
VL  - 32
IS  - 1
PB  - American Institute of Physics
CY  - Woodbury, NY
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Caesar, Levke
A1  - Marwan, Norbert
A1  - Maheswaran, Rathinasamy
A1  - Merz, Bruno
T1  - Network-based identification and characterization of teleconnections on different scales
JF  - Scientific Reports
N2  - Sea surface temperature (SST) patterns can – as surface climate forcing – affect weather and climate at large distances. One example is El Niño-Southern Oscillation (ENSO) that causes climate anomalies around the globe via teleconnections. Although several studies identified and characterized these teleconnections, our understanding of climate processes remains incomplete, since interactions and feedbacks are typically exhibited at unique or multiple temporal and spatial scales. This study characterizes the interactions between the cells of a global SST data set at different temporal and spatial scales using climate networks. These networks are constructed using wavelet multi-scale correlation that investigate the correlation between the SST time series at a range of scales allowing instantaneously deeper insights into the correlation patterns compared to traditional methods like empirical orthogonal functions or classical correlation analysis. This allows us to identify and visualise regions of – at a certain timescale – similarly evolving SSTs and distinguish them from those with long-range teleconnections to other ocean regions. Our findings re-confirm accepted knowledge about known highly linked SST patterns like ENSO and the Pacific Decadal Oscillation, but also suggest new insights into the characteristics and origins of long-range teleconnections like the connection between ENSO and Indian Ocean Dipole.
Y1  - 2019
U6  - https://doi.org/10.1038/s41598-019-45423-5
SN  - 2045-2322
VL  - 9
PB  - Macmillan Publishers Limited
CY  - London
ER  - 
TY  - JOUR
A1  - Agada, S.
A1  - Chen, F.
A1  - Geiger, S.
A1  - Toigulova, G.
A1  - Agar, Susan M.
A1  - Shekhar, R.
A1  - Benson, Gregory S.
A1  - Hehmeyer, O.
A1  - Amour, Frédéric
A1  - Mutti, Maria
A1  - Christ, Nicolas
A1  - Immenhauser, A.
T1  - Numerical simulation of fluid-flow processes in a 3D high-resolution carbonate reservoir analogue
JF  - Petroleum geoscience
N2  - A high-resolution three-dimensional (3D) outcrop model of a Jurassic carbonate ramp was used in order to perform a series of detailed and systematic flow simulations. The aim of this study was to test the impact of small- and large-scale geological features on reservoir performance and oil recovery. The digital outcrop model contains a wide range of sedimentological, diagenetic and structural features, including discontinuity surfaces, shoal bodies, mud mounds, oyster bioherms and fractures. Flow simulations are performed for numerical well testing and secondary oil recovery. Numerical well testing enables synthetic but systematic pressure responses to be generated for different geological features observed in the outcrops. This allows us to assess and rank the relative impact of specific geological features on reservoir performance. The outcome documents that, owing to the realistic representation of matrix heterogeneity, most diagenetic and structural features cannot be linked to a unique pressure signature. Instead, reservoir performance is controlled by subseismic faults and oyster bioherms acting as thief zones. Numerical simulations of secondary recovery processes reveal strong channelling of fluid flow into high-permeability layers as the primary control for oil recovery. However, appropriate reservoir-engineering solutions, such as optimizing well placement and injection fluid, can reduce channelling and increase oil recovery.
Y1  - 2014
U6  - https://doi.org/10.1144/petgeo2012-096
SN  - 1354-0793
VL  - 20
IS  - 1
SP  - 125
EP  - 142
PB  - Geological Soc. Publ. House
CY  - Bath
ER  - 
TY  - JOUR
A1  - Aga-Barfknecht, Heja
A1  - Soultoukis, George A.
A1  - Stadion, Mandy
A1  - Garcia-Carrizo, Francisco
A1  - Jähnert, Markus
A1  - Gottmann, Pascal
A1  - Vogel, Heike
A1  - Schulz, Tim Julius
A1  - Schürmann, Annette
T1  - Distinct adipogenic and fibrogenic differentiation capacities of mesenchymal stromal cells from pancreas and white adipose tissue
JF  - International journal of molecular sciences
N2  - Pancreatic steatosis associates with beta-cell failure and may participate in the development of type-2-diabetes. Our previous studies have shown that diabetes-susceptible mice accumulate more adipocytes in the pancreas than diabetes-resistant mice. In addition, we have demonstrated that the co-culture of pancreatic islets and adipocytes affect insulin secretion. The aim of this current study was to elucidate if and to what extent pancreas-resident mesenchymal stromal cells (MSCs) with adipogenic progenitor potential differ from the corresponding stromal-type cells of the inguinal white adipose tissue (iWAT). miRNA (miRNome) and mRNA expression (transcriptome) analyses of MSCs isolated by flow cytometry of both tissues revealed 121 differentially expressed miRNAs and 1227 differentially expressed genes (DEGs). Target prediction analysis estimated 510 DEGs to be regulated by 58 differentially expressed miRNAs. Pathway analyses of DEGs and miRNA target genes showed unique transcriptional and miRNA signatures in pancreas (pMSCs) and iWAT MSCs (iwatMSCs), for instance fibrogenic and adipogenic differentiation, respectively. Accordingly, iwatMSCs revealed a higher adipogenic lineage commitment, whereas pMSCs showed an elevated fibrogenesis. As a low degree of adipogenesis was also observed in pMSCs of diabetes-susceptible mice, we conclude that the development of pancreatic steatosis has to be induced by other factors not related to cell-autonomous transcriptomic changes and miRNA-based signals.
KW  - MSCs
KW  - fatty pancreas
KW  - WAT
KW  - lineage commitment
KW  - transcriptomics
KW  - miRNAs
Y1  - 2022
U6  - https://doi.org/10.3390/ijms23042108
SN  - 1422-0067
VL  - 23
IS  - 4
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  - 
TY  - JOUR
A1  - Aga-Barfknecht, Heja
A1  - Hallahan, Nicole
A1  - Gottmann, Pascal
A1  - Jähnert, Markus
A1  - Osburg, Sophie
A1  - Schulze, Gunnar
A1  - Kamitz, Anne
A1  - Arends, Danny
A1  - Brockmann, Gudrun
A1  - Schallschmidt, Tanja
A1  - Lebek, Sandra
A1  - Chadt, Alexandra
A1  - Al-Hasani, Hadi
A1  - Joost, Hans-Georg
A1  - Schürmann, Annette
A1  - Vogel, Heike
T1  - Identification of novel potential type 2 diabetes genes mediating beta-cell loss and hyperglycemia using positional cloning
JF  - Frontiers in genetics
N2  - Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility were crossed with the obese and diabetes-prone New Zealand obese (NZO) mouse. Subsequent whole-genome sequence scans revealed one major quantitative trait loci (QTL),Nidd/DBAon chromosome 4, linked to elevated blood glucose and reduced plasma insulin and low levels of pancreatic insulin. Phenotypical characterization of congenic mice carrying 13.6 Mbp of the critical fragment of DBA mice displayed severe hyperglycemia and impaired glucose clearance at week 10, decreased glucose response in week 13, and loss of beta-cells and pancreatic insulin in week 16. To identify the responsible gene variant(s), further congenic mice were generated and phenotyped, which resulted in a fragment of 3.3 Mbp that was sufficient to induce hyperglycemia. By combining transcriptome analysis and haplotype mapping, the number of putative responsible variant(s) was narrowed from initial 284 to 18 genes, including gene models and non-coding RNAs. Consideration of haplotype blocks reduced the number of candidate genes to four (Kti12,Osbpl9,Ttc39a, andCalr4) as potential T2D candidates as they display a differential expression in pancreatic islets and/or sequence variation. In conclusion, the integration of comparative analysis of multiple inbred populations such as haplotype mapping, transcriptomics, and sequence data substantially improved the mapping resolution of the diabetes QTLNidd/DBA. Future studies are necessary to understand the exact role of the different candidates in beta-cell function and their contribution in maintaining glycemic control.
KW  - type 2 diabetes
KW  - beta-cell loss
KW  - insulin
KW  - positional cloning
KW  - transcriptomics
KW  - haplotype
Y1  - 2020
U6  - https://doi.org/10.3389/fgene.2020.567191
SN  - 1664-8021
VL  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Afshari Moein, Mohammad J.
A1  - Somogyvári, Márk
A1  - Valley, Benoît
A1  - Jalali, Mohammadreza
A1  - Löw, Simon
A1  - Bayer, Peter
T1  - Fracture network characterization using stress-based tomography
JF  - Journal of geophysical research : JGR
N2  - Information on structural features of a fracture network at early stages of Enhanced Geothermal System development is mostly restricted to borehole images and, if available, outcrop data. However, using this information to image discontinuities in deep reservoirs is difficult. Wellbore failure data provides only some information on components of the in situ stress state and its heterogeneity. Our working hypothesis is that slip on natural fractures primarily controls these stress heterogeneities. Based on this, we introduce stress-based tomography in a Bayesian framework to characterize the fracture network and its heterogeneity in potential Enhanced Geothermal System reservoirs. In this procedure, first a random initial discrete fracture network (DFN) realization is generated based on prior information about the network. The observations needed to calibrate the DFN are based on local variations of the orientation and magnitude of at least one principal stress component along boreholes. A Markov Chain Monte Carlo sequence is employed to update the DFN iteratively by a fracture translation within the domain. The Markov sequence compares the simulated stress profile with the observed stress profiles in the borehole, evaluates each iteration with Metropolis-Hastings acceptance criteria, and stores acceptable DFN realizations in an ensemble. Finally, this obtained ensemble is used to visualize the potential occurrence of fractures in a probability map, indicating possible fracture locations and lengths. We test this methodology to reconstruct simple synthetic and more complex outcrop-based fracture networks and successfully image the significant fractures in the domain.
KW  - fracture network
KW  - Bayesian inversion
KW  - stress variability
KW  - rock mechanics
Y1  - 2018
U6  - https://doi.org/10.1029/2018JB016438
SN  - 2169-9313
SN  - 2169-9356
VL  - 123
IS  - 11
SP  - 9324
EP  - 9340
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Afshaarvahid, Shahraam
A1  - Heuer, Axel
A1  - Menzel, Ralf
A1  - Munch, Jesper
T1  - Temporal structure of stimulated-Brillouin-scattering reflectivity considering transversal-mode development
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Afantenos, Stergos
A1  - Peldszus, Andreas
A1  - Stede, Manfred
T1  - Comparing decoding mechanisms for parsing argumentative structures
JF  - Argument & Computation
N2  - Parsing of argumentative structures has become a very active line of research in recent years. Like discourse parsing or any other natural language task that requires prediction of linguistic structures, most approaches choose to learn a local model and then perform global decoding over the local probability distributions, often imposing constraints that are specific to the task at hand. Specifically for argumentation parsing, two decoding approaches have been recently proposed: Minimum Spanning Trees (MST) and Integer Linear Programming (ILP), following similar trends in discourse parsing. In contrast to discourse parsing though, where trees are not always used as underlying annotation schemes, argumentation structures so far have always been represented with trees. Using the ‘argumentative microtext corpus’ [in: Argumentation and Reasoned Action: Proceedings of the 1st European Conference on Argumentation, Lisbon 2015 / Vol. 2, College Publications, London, 2016, pp. 801–815] as underlying data and replicating three different decoding mechanisms, in this paper we propose a novel ILP decoder and an extension to our earlier MST work, and then thoroughly compare the approaches. The result is that our new decoder outperforms related work in important respects, and that in general, ILP and MST yield very similar performance.
KW  - Argumentation structure
KW  - argument mining
KW  - parsing
Y1  - 2018
U6  - https://doi.org/10.3233/AAC-180033
SN  - 1946-2166
SN  - 1946-2174
VL  - 9
IS  - 3
SP  - 177
EP  - 192
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Aerts, J. C. J. H.
A1  - Botzen, W. J. Wouter
A1  - Clarke, K. C.
A1  - Cutter, S. L.
A1  - Hall, J. W.
A1  - Merz, Bruno
A1  - Michel-Kerjan, E.
A1  - Mysiak, J.
A1  - Surminski, Swenja
A1  - Kunreuther, H.
T1  - Integrating human behaviour dynamics into flood disaster risk assessment
JF  - Nature climate change
N2  - The behaviour of individuals, businesses, and government entities before, during, and immediately after a disaster can dramatically affect the impact and recovery time. However, existing risk-assessment methods rarely include this critical factor. In this Perspective, we show why this is a concern, and demonstrate that although initial efforts have inevitably represented human behaviour in limited terms, innovations in flood-risk assessment that integrate societal behaviour and behavioural adaptation dynamics into such quantifications may lead to more accurate characterization of risks and improved assessment of the effectiveness of risk-management strategies and investments. Such multidisciplinary approaches can inform flood-risk management policy development.
Y1  - 2018
U6  - https://doi.org/10.1038/s41558-018-0085-1
SN  - 1758-678X
SN  - 1758-6798
VL  - 8
IS  - 3
SP  - 193
EP  - 199
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Adreeva, Anna
T1  - Frauenfilmdramaturgie im Russischen Kaiserreich der 1910er Jahre
BT  - Film, Media and Digital Cultures of Central and Eastern Europe
JF  - Apparatus
N2  - Im Artikel werden von Frauen verfasste Filmdrehbücher der 1910er Jahre im Russischen Kaiserreich chronologisch untersucht. Zunächst werden die ersten Drehbuchautorinnen Makarova und Tat’jana Suchotina-Tolstaja, die am Anfang der 1910er Jahre in Koautorschaft mit den bekannten Autoren (Makarova mit den Regisseur Vladimir Gončarov; Suchotina-Tolstaja mit ihrem Vater Leo Tolstoj) arbeiteten, und ihre Filme in Betracht gezogen. Dann wird der Film Ključi sčastʹja / Schlüssel zum Glück (Vladimir Gardin, Jakov Protazanov, 1913, Russisches Kaiserreich) nach dem Roman von Anastasija Verbickaja näher behandelt. Verbickajas Film demonstrierte, dass eine Drehbuchautorin eine selbständige Autorin sein kann und diente als Impuls für die Entwicklung der Frauenfilmdramaturgie im Russischen Kaiserreich, deren Aufschwung in der zweiten Hälfte der 1910er Jahre begann, und prägte bestimmte Erwartungen von auf weiblichen Drehbüchern basierenden Filmen. Maria Kallaš, die an den Drehbüchern zu den Verfilmungen des russischen literarischen Kanons 1913 arbeitete, kritisierte Verbickajas Text als pseudofeministisch und behauptete in ihrem Essay „Ženskie kabare“ („Frauenkabarett“), dass Frauenliteratur noch „keine eigene Sprache“ habe (1916). Anna Mar begann ihre Arbeit im Kino 1914, parallel zu Verbiсkajas Nachfolgerinnen, und konzentrierte sich in ihren Filmen auf die soziale Problematik – die Stellung moderner Frauen in der Gesellschaft. Damit eröffnete Mar eine neue Entwicklungsperspektive für das weibliche Drehbuchschreiben.
N2  - This article provides a chronological examination of women’s screenwriting in the 1910s in the Russian Empire. The first women screenwriters, Makarova and Tat’iana Suchotina-Tolstaia, worked in the early 1910s as co-authors with popular men writers (Makarova with the director Vladimir Goncharov and Sukhotina-Tolstaia with her father Lev Tolstoi). The film Kliuchi schast’ia / The Keys to Happiness (Vladimir Gardin, Iakov Protazanov, 1913, Russian Empire), based on Anastasiia Verbitskaia’s novel of the same title, proved that a woman screenwriter could be an independent author, influencing the development of women’s screenwriting in the Russian Empire, which took off in the second half of the 1910s, creating certain expectations for films written by women. Mariia Kallash, who worked on the screenplays for film adaptations of the Russian literary canon in 1913, criticised Verbitskaia’s text for its pseudo-feminism and claimed, in her essay “Women’s Cabaret”, that women’s literature still “did not have its own language” (1916). Anna Mar wrote for the screen in the second half of the 1910s, at the same time as Verbitskaia’s successors. In Mar’s screenplays, she focused on social problems and particularly on women’s position in modern society, suggesting a different perspective for women’s screenwriting in the Russian Empire.
N2  - В настоящей статье речь пойдет о женской кинодраматургии 1910-х гг. в Российской империи. Сперва мы восстановим творческую судьбу первых сценаристок Макаровой и Татьяны Сухотиной-Толстой, которые работали в соавторстве с известными -авторами-мужчинами (Макарова – с режиссером Владимиром Гончаровым; Сухотина-Толстая – со своим отцом Львом Толстым) на рубеже 1910-х гг. Затем подробнее остановимся на  фильме Ключи счастья (Владимир Гардин, Яков Протазанов, 1913, Российская империя) по одноименному роману Анастасии Вербицкой, которая считается автором сценария картины. Фильм Ключи счастья показал, что женщина может быть независимым автором, послужил толчком к развитию женской драматургии в Российской империи, подъем которой начался во второй половине 1910-х гг., и сформировал определенные ожидания от фильмов по сценариям, написанными авторами-женщинами. Мария Каллаш, автор экранизаций текстов русской литературы, раскритиковала роман Вербицкой за псевдофеминизм и в эссе «Женские кабаре» заявила, что женская литература до сих пор «не имеет своего собственного языка» (1916). Анна Мар пришла в кино в 1914 году одновременно с преемниками Вербицкой и сосредоточилась в своих фильмах на социальной проблематике, а именно – на положении современных женщин в обществе. Тем самым Мар предложила новую перспективу для развития женского киносценария.
T2  - Women’s Screenwriting of the 1910s in the Russian Empire
T2  - Женская кинодраматургия в Российской империи 1910-х годов
KW  - Anastasija Verbickaja
KW  - Maria Kallaš
KW  - Anna Mar
KW  - Rovdo
KW  - Antalek
KW  - Russisches K​a​iserreich
KW  - frühes russländisches Kino
KW  - Frauenfilmdramaturgie
KW  - Frauenliteratur
KW  - Feminismus
KW  - Drehbuch
KW  - Анастасия Вербицкая
KW  - Мария Каллаш
KW  - Анна Мар
KW  - Ровдо
KW  - Анталек
KW  - Российская империя
KW  - раннее российское кино
KW  - женская кинодраматургия
KW  - женская литература
KW  - феминизм
KW  - feminism
KW  - women’s literature
KW  - women’s screenwriting
KW  - early cinema in the Russian Empire
KW  - Russian Empire
KW  - Antalek
KW  - Rovdo
KW  - Anna Mar
KW  - Mariia Kallash
KW  - Anastasiia Verbitskaia
KW  - screenplays
KW  - scripts
KW  - сценарий
Y1  - 2022
U6  - https://doi.org/10.17892/app.2022.00015.270
SN  - 2365-7758
VL  - 13
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Adolfs, Marjolijn
A1  - Hoque, Mohammed Mainul
A1  - Shprits, Yuri
T1  - Storm-time relative total electron content modelling using machine learning techniques
JF  - Remote sensing
N2  - Accurately predicting total electron content (TEC) during geomagnetic storms is still a challenging task for ionospheric models. In this work, a neural-network (NN)-based model is proposed which predicts relative TEC with respect to the preceding 27-day median TEC, during storm time for the European region (with longitudes 30 degrees W-50 degrees E and latitudes 32.5 degrees N-70 degrees N). The 27-day median TEC (referred to as median TEC), latitude, longitude, universal time, storm time, solar radio flux index F10.7, global storm index SYM-H and geomagnetic activity index Hp30 are used as inputs and the output of the network is the relative TEC. The relative TEC can be converted to the actual TEC knowing the median TEC. The median TEC is calculated at each grid point over the European region considering data from the last 27 days before the storm using global ionosphere maps (GIMs) from international GNSS service (IGS) sources. A storm event is defined when the storm time disturbance index Dst drops below 50 nanotesla. The model was trained with storm-time relative TEC data from the time period of 1998 until 2019 (2015 is excluded) and contains 365 storms. Unseen storm data from 33 storm events during 2015 and 2020 were used to test the model. The UQRG GIMs were used because of their high temporal resolution (15 min) compared to other products from different analysis centers. The NN-based model predictions show the seasonal behavior of the storms including positive and negative storm phases during winter and summer, respectively, and show a mixture of both phases during equinoxes. The model's performance was also compared with the Neustrelitz TEC model (NTCM) and the NN-based quiet-time TEC model, both developed at the German Aerospace Agency (DLR). The storm model has a root mean squared error (RMSE) of 3.38 TEC units (TECU), which is an improvement by 1.87 TECU compared to the NTCM, where an RMSE of 5.25 TECU was found. This improvement corresponds to a performance increase by 35.6%. The storm-time model outperforms the quiet-time model by 1.34 TECU, which corresponds to a performance increase by 28.4% from 4.72 to 3.38 TECU. The quiet-time model was trained with Carrington averaged TEC and, therefore, is ideal to be used as an input instead of the GIM derived 27-day median. We found an improvement by 0.8 TECU which corresponds to a performance increase by 17% from 4.72 to 3.92 TECU for the storm-time model using the quiet-time-model predicted TEC as an input compared to solely using the quiet-time model.
KW  - ionosphere
KW  - relative total electron content
KW  - geomagnetic storms
KW  - neural
KW  - networks
KW  - NTCM
KW  - European storm-time model
Y1  - 2022
U6  - https://doi.org/10.3390/rs14236155
SN  - 2072-4292
VL  - 14
IS  - 23
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Adnan, Hassan Sami
A1  - Matthews, Sam
A1  - Hackl, M.
A1  - Das, P. P.
A1  - Manaswini, Manisha
A1  - Gadamsetti, S.
A1  - Filali, Maroua
A1  - Owoyele, Babajide
A1  - Santuber, Joaquín
A1  - Edelman, Jonathan
T1  - Human centered AI design for clinical monitoring and data management
JF  - European journal of public health : official journal of the European Health Association
N2  - In clinical settings, significant resources are spent on data collection and monitoring patients' health parameters to improve decision-making and provide better care. With increased digitization, the healthcare sector is shifting towards implementing digital technologies for data management and in administration. New technologies offer better treatment opportunities and streamline clinical workflow, but the complexity can cause ineffectiveness, frustration, and errors. To address this, we believe digital solutions alone are not sufficient. Therefore, we take a human-centred design approach for AI development, and apply systems engineering methods to identify system leverage points. We demonstrate how automation enables monitoring clinical parameters, using existing non-intrusive sensor technology, resulting in more resources toward patient care. Furthermore, we provide a framework on digitization of clinical data for integration with data management.
Y1  - 2020
U6  - https://doi.org/10.1093/eurpub/ckaa165.225
SN  - 1101-1262
SN  - 1464-360X
VL  - 30
IS  - 5
SP  - V86
EP  - V86
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Adhikari, Rishi Ram
A1  - Kallmeyer, Jens
T1  - Detection and quantification of microbial activity in the subsurface
N2  - The subsurface harbors a large fraction of Earth's living biomass, forming complex microbial ecosystems. Without a profound knowledge of the ongoing biologically mediated processes and their reaction to anthropogenic changes it is difficult to assess the long-term stability and feasibility of any type of geotechnical utilization, as these influence subsurface ecosystems. Despite recent advances in many areas of subsurface microbiology, the direct quantification of turnover processes is still in its infancy, mainly due to the extremely low cell abundances. We provide an overview of the currently available techniques for the quantification of microbial turnover processes and discuss their specific strengths and limitations. Most techniques employed so far have focused on specific processes, e.g. sulfate reduction or methanogenesis. Recent studies show that processes that were previously thought to exclude each other can occur simultaneously, albeit at very low rates. Without the identification of the respective processes it is impossible to quantify total microbial activity. Even in cases where all simultaneously occurring processes can be identified, the typically very low rates prevent quantification. In many cases a simple measure of total microbial activity would be a better and more robust measure than assays for several specific processes. Enzyme or molecular assays provide a more general approach as they target key metabolic compounds. Depending on the compound targeted a broader spectrum of microbial processes can be quantified. The two most promising compounds are ATP and hydrogenase, as both are ubiquitous in microbes. Technical constraints limit the applicability of currently available ATP-assays for subsurface samples. A recently developed hydrogenase radiotracer assay has the potential to become a key tool for the quantification of subsurface microbial activity.
Y1  - 2010
UR  - http://www.sciencedirect.com/science/journal/00092819
U6  - https://doi.org/10.1016/j.chemer.2010.05.003
SN  - 0009-2819
ER  - 
TY  - JOUR
A1  - Adhikari, Rishi Ram
A1  - Glombitza, Clemens
A1  - Nickel, Julia C.
A1  - Anderson, Chloe H.
A1  - Dunlea, Ann G.
A1  - Spivack, Arthur J.
A1  - Murray, Richard W.
A1  - Kallmeyer, Jens
T1  - Hydrogen Utilization Potential in Subsurface Sediments
JF  - Frontiers in microbiology
N2  - Subsurface microbial communities undertake many terminal electron-accepting processes, often simultaneously. Using a tritium-based assay, we measured the potential hydrogen oxidation catalyzed by hydrogenase enzymes in several subsurface sedimentary environments (Lake Van, Barents Sea, Equatorial Pacific, and Gulf of Mexico) with different predominant electron-acceptors. Hydrogenases constitute a diverse family of enzymes expressed by microorganisms that utilize molecular hydrogen as a metabolic substrate, product, or intermediate. The assay reveals the potential for utilizing molecular hydrogen and allows qualitative detection of microbial activity irrespective of the predominant electron-accepting process. Because the method only requires samples frozen immediately after recovery, the assay can be used for identifying microbial activity in subsurface ecosystems without the need to preserve live material. We measured potential hydrogen oxidation rates in all samples from multiple depths at several sites that collectively span a wide range of environmental conditions and biogeochemical zones. Potential activity normalized to total cell abundance ranges over five orders of magnitude and varies, dependent upon the predominant terminal electron acceptor. Lowest per-cell potential rates characterize the zone of nitrate reduction and highest per-cell potential rates occur in the methanogenic zone. Possible reasons for this relationship to predominant electron acceptor include (i) increasing importance of fermentation in successively deeper biogeochemical zones and (ii) adaptation of H(2)ases to successively higher concentrations of H-2 in successively deeper zones.
KW  - hydrogenase
KW  - tritium assay
KW  - deep biosphere
KW  - microbial activity
KW  - Lake Van
KW  - Barents Sea
KW  - Equatorial Pacific
KW  - Gulf of Mexico
Y1  - 2016
U6  - https://doi.org/10.3389/fmicb.2016.00008
SN  - 1664-302X
VL  - 7
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Adesina, Morenike O.
A1  - Block, Inga
A1  - Günter, Christina
A1  - Unuabonah, Emmanuel Iyayi
A1  - Taubert, Andreas
T1  - Efficient Removal of Tetracycline and Bisphenol A from Water with a New Hybrid Clay/TiO2 Composite
JF  - ACS Omega
N2  - New TiO2 hybrid composites were prepared fromkaolinclay, predried and carbonized biomass, and titanium tetraisopropoxideand explored for tetracycline (TET) and bisphenol A (BPA) removalfrom water. Overall, the removal rate is 84% for TET and 51% for BPA.The maximum adsorption capacities (q (m))are 30 and 23 mg/g for TET and BPA, respectively. These capacitiesare far greater than those obtained for unmodified TiO2. Increasing the ionic strength of the solution does not change theadsorption capacity of the adsorbent. pH changes only slightly changeBPA adsorption, while a pH > 7 significantly reduces the adsorptionof TET on the material. The Brouers-Sotolongo fractal modelbest describes the kinetic data for both TET and BPA adsorption, predictingthat the adsorption process occurs via a complex mechanism involvingvarious forces of attraction. Temkin and Freundlich isotherms, whichbest fit the equilibrium adsorption data for TET and BPA, respectively,suggest that adsorption sites are heterogeneous in nature. Overall,the composite materials are much more effective for TET removal fromaqueous solution than for BPA. This phenomenon is assigned to a differencein the TET/adsorbent interactions vs the BPA/adsorbent interactions:the decisive factor appears to be favorable electrostatic interactionsfor TET yielding a more effective TET removal.
Y1  - 2023
U6  - https://doi.org/10.1021/acsomega.3c00184
SN  - 2470-1343
VL  - 8
IS  - 24
SP  - 21594
EP  - 21604
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Adem, Fozia A.
A1  - Mbaveng, Armelle T.
A1  - Kuete, Victor
A1  - Heydenreich, Matthias
A1  - Ndakala, Albert
A1  - Irungu, Beatrice
A1  - Yenesew, Abiy
A1  - Efferth, Thomas
T1  - Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer
JF  - Phytomedicine : international journal of phytotherapy and phytopharmacology
N2  - Background: While incidences of cancer are continuously increasing, drug resistance of malignant cells is observed towards almost all pharmaceuticals. Several isoflavonoids and flavonoids are known for their cytotoxicity towards various cancer cells. Methods: The cytotoxicity of compounds was determined based on the resazurin reduction assay. Caspases activation was evaluated using the caspase-Glo assay. Flow cytometry was used to analyze the cell cycle (propodium iodide (PI) staining), apoptosis (annexin V/PI staining), mitochondrial membrane potential (MMP) (JC-1) and reactive oxygen species (ROS) (H2DCFH-DA). CCRF-CEM leukemia cells were used as model cells for mechanistic studies. Results: Compounds 1, 2 and 4 displayed IC50 values below 20 mu M towards CCRF-CEM and CEM/ADR5000 leukemia cells, and were further tested towards a panel of 7 carcinoma cells. The IC50 values of the compounds against carcinoma cells varied from 16.90 mu M (in resistant U87MG.Delta EGFR glioblastoma cells) to 48.67 mu M (against HepG2 hepatocarcinoma cells) for 1, from 7.85 mu M (in U87MG.Delta EGFR cells) to 14.44 mu M (in resistant MDA-MB231/BCRP breast adenocarcinoma cells) for 2, from 4.96 mu M (towards U87MG.Delta EGFRcells) to 7.76 mu M (against MDA-MB231/BCRP cells) for 4, and from 0.07 mu M (against MDA-MB231 cells) to 2.15 mu M (against HepG2 cells) for doxorubicin. Compounds 2 and 4 induced apoptosis in CCRF-CEM cells mediated by MMP alteration and increased ROS production. Conclusion: The present report indicates that isoflavones and biflavonoids from Ormocarpum kirkii are cytotoxic compounds with the potential of being exploited in cancer chemotherapy. Compounds 2 and 4 deserve further studies to develop new anticancer drugs to fight sensitive and resistant cancer cell lines.
KW  - Apoptosis
KW  - Cancer
KW  - Ormocarpum kirkii
KW  - Isoflavone
KW  - Biflavonoid
KW  - Multi-drug resistance
Y1  - 2019
U6  - https://doi.org/10.1016/j.phymed.2019.152853
SN  - 0944-7113
SN  - 1618-095X
VL  - 58
PB  - Elsevier
CY  - München
ER  - 
TY  - JOUR
A1  - Adem, Fozia A.
A1  - Kuete, Victor
A1  - Mbaveng, Armelle T.
A1  - Heydenreich, Matthias
A1  - Ndakala, Albert
A1  - Irungu, Beatrice
A1  - Efferth, Thomas
A1  - Yenesew, Abiy
T1  - Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana
JF  - Fitoterapia
N2  - Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol (3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1-4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC50 values of 7.17 mu M and 5.16 mu M, respectively) against CCRF-CEM leukemia cells. Compound 5 also showed cytotoxicity against 7 sensitive or drug-resistant solid tumor cell lines (breast carcinoma, colon carcinoma, glioblastoma), with IC50 below 50 mu M, whilst 4 showed selective activity.
KW  - Dorstenia kameruniana
KW  - Moraceae
KW  - Benzylbenzofuran
KW  - Furanocoumarin
KW  - Chalcone
KW  - Cytotoxicity
Y1  - 2018
U6  - https://doi.org/10.1016/j.fitote.2018.04.019
SN  - 0367-326X
SN  - 1873-6971
VL  - 128
SP  - 26
EP  - 30
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Adem, Fozia A.
A1  - Kuete, Victor
A1  - Mbaveng, Armelle T.
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Ndakala, Albert
A1  - Irungu, Beatrice
A1  - Yenesew, Abiy
A1  - Efferth, Thomas
T1  - Cytotoxic flavonoids from two Lonchocarpus species
JF  - Natural Product Research
N2  - A new isoflavone, 4′-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2′-dimethoxy-3′,4′-methylenedioxyisoflavone, 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells.
KW  - Lonchocarpus bussei
KW  - Lonchocarpus eriocalyx
KW  - Leguminosae
KW  - isoflavone
KW  - pterocarpan
KW  - cytotoxicity
Y1  - 2019
U6  - https://doi.org/10.1080/14786419.2018.1462179
SN  - 1478-6419
SN  - 1478-6427
VL  - 33
IS  - 18
SP  - 2609
EP  - 2617
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Adelt, Anne
A1  - Stadie, Nicole
A1  - Lassotta, Romy
A1  - Adani, Flavia
A1  - Burchert, Frank
T1  - Feature dissimilarities in the processing of German relative clauses in aphasia
JF  - Journal of neurolinguistics : an international journal for the study of brain function in language behavior and experience
N2  - The cross-linguistic finding of greater demands in processing object relatives as compared to subject relatives in individuals with aphasia and non-brain-damaged speakers has been explained within the Relativized Minimality approach. Based on this account, the asymmetry is attributed to an element intervening between the moved element and its extraction site in object relatives, but not in subject relatives. Moreover, it has been proposed that processing of object relatives is facilitated if the intervening and the moved elements differ in their internal feature structure. The present study investigates these predictions in German-speaking individuals with aphasia and a group of control participants by combining the visual world eye-tracking methodology with an auditory referent identification task. Our results provide support for the Relativized Minimality approach. Particularly, the degree of featural distinctness was shown to modulate the occurrence of the effects in aphasia. We claim that, due to reduced processing capacities, individuals with aphasia need a higher degree of featural dissimilarity to distinguish the moved from the intervening element in object relatives to overcome their syntactic deficit. (C) 2017 Elsevier Ltd. All rights reserved.
KW  - Aphasia
KW  - Relative clauses
KW  - Relativized Minimality
KW  - Sentence processing
KW  - Morpho-syntactic features
KW  - Eye tracking
Y1  - 2017
U6  - https://doi.org/10.1016/j.jneuroling.2017.01.002
SN  - 0911-6044
VL  - 44
SP  - 17
EP  - 37
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Adelt, Anne
A1  - Hanne, Sandra
A1  - Stadie, Nicole
T1  - Treatment of sentence comprehension and production in aphasia
BT  - is there cross-modal generalisation?
JF  - Neuropsychological rehabilitation
N2  - Exploring generalisation following treatment of language deficits in aphasia can provide insights into the functional relation of the cognitive processing systems involved. In the present study, we first review treatment outcomes of interventions targeting sentence processing deficits and, second report a treatment study examining the occurrence of practice effects and generalisation in sentence comprehension and production. In order to explore the potential linkage between processing systems involved in comprehending and producing sentences, we investigated whether improvements generalise within (i.e., uni-modal generalisation in comprehension or in production) and/or across modalities (i.e., cross-modal generalisation from comprehension to production or vice versa). Two individuals with aphasia displaying co-occurring deficits in sentence comprehension and production were trained on complex, non-canonical sentences in both modalities. Two evidence-based treatment protocols were applied in a crossover intervention study with sequence of treatment phases being randomly allocated. Both participants benefited significantly from treatment, leading to uni-modal generalisation in both comprehension and production. However, cross-modal generalisation did not occur. The magnitude of uni-modal generalisation in sentence production was related to participants’ sentence comprehension performance prior to treatment. These findings support the assumption of modality-specific sub-systems for sentence comprehension and production, being linked uni-directionally from comprehension to production.
KW  - Sentence comprehension
KW  - sentence production
KW  - cross-modal generalisation
KW  - aphasia treatment
Y1  - 2016
U6  - https://doi.org/10.1080/09602011.2016.1213176
SN  - 0960-2011
SN  - 1464-0694
VL  - 28
IS  - 6
SP  - 937
EP  - 965
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  -