TY - GEN A1 - Halfpap, Stefan A1 - Schlosser, Rainer T1 - A Comparison of Allocation Algorithms for Partially Replicated Databases T2 - 2019 IEEE 35th International Conference on Data Engineering (ICDE) N2 - Increasing demand for analytical processing capabilities can be managed by replication approaches. However, to evenly balance the replicas' workload shares while at the same time minimizing the data replication factor is a highly challenging allocation problem. As optimal solutions are only applicable for small problem instances, effective heuristics are indispensable. In this paper, we test and compare state-of-the-art allocation algorithms for partial replication. By visualizing and exploring their (heuristic) solutions for different benchmark workloads, we are able to derive structural insights and to detect an algorithm's strengths as well as its potential for improvement. Further, our application enables end-to-end evaluations of different allocations to verify their theoretical performance. Y1 - 2019 SN - 978-1-5386-7474-1 SN - 978-1-5386-7475-8 U6 - https://doi.org/10.1109/ICDE.2019.00226 SN - 1084-4627 SN - 2375-026X SN - 1063-6382 SP - 2008 EP - 2011 PB - IEEE CY - New York ER - TY - JOUR A1 - Baroni, Gabriele A1 - Schalge, Bernd A1 - Rakovec, Oldrich A1 - Kumar, Rohini A1 - Schüler, Lennart A1 - Samaniego, Luis A1 - Simmer, Clemens A1 - Attinger, Sabine T1 - A Comprehensive Distributed Hydrological Modeling Intercomparison to Support Process Representation and Data Collection Strategies JF - Water resources research N2 - The improvement of process representations in hydrological models is often only driven by the modelers' knowledge and data availability. We present a comprehensive comparison between two hydrological models of different complexity that is developed to support (1) the understanding of the differences between model structures and (2) the identification of the observations needed for model assessment and improvement. The comparison is conducted on both space and time and by aggregating the outputs at different spatiotemporal scales. In the present study, mHM, a process‐based hydrological model, and ParFlow‐CLM, an integrated subsurface‐surface hydrological model, are used. The models are applied in a mesoscale catchment in Germany. Both models agree in the simulated river discharge at the outlet and the surface soil moisture dynamics, lending their supports for some model applications (drought monitoring). Different model sensitivities are, however, found when comparing evapotranspiration and soil moisture at different soil depths. The analysis supports the need of observations within the catchment for model assessment, but it indicates that different strategies should be considered for the different variables. Evapotranspiration measurements are needed at daily resolution across several locations, while highly resolved spatially distributed observations with lower temporal frequency are required for soil moisture. Finally, the results show the impact of the shallow groundwater system simulated by ParFlow‐CLM and the need to account for the related soil moisture redistribution. Our comparison strategy can be applied to other models types and environmental conditions to strengthen the dialog between modelers and experimentalists for improving process representations in Earth system models. KW - hydrological models KW - assessments KW - monitoring strategies KW - improvements Y1 - 2019 U6 - https://doi.org/10.1029/2018WR023941 SN - 0043-1397 SN - 1944-7973 VL - 55 IS - 2 SP - 990 EP - 1010 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Chapman, Eric M. A1 - Lant, Benjamin A1 - Ohashi, Yota A1 - Yu, Bin A1 - Schertzberg, Michael A1 - Go, Christopher A1 - Dogra, Deepika A1 - Koskimaki, Janne A1 - Girard, Romuald A1 - Li, Yan A1 - Fraser, Andrew G. A1 - Awad, Issam A. A1 - Abdelilah-Seyfried, Salim A1 - Gingras, Anne-Claude A1 - Derry, William Brent T1 - A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis JF - Nature Communications N2 - Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease. Y1 - 2019 U6 - https://doi.org/10.1038/s41467-019-09829-z SN - 2041-1723 VL - 10 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Winter, Benjamin A1 - Schneeberger, Klaus A1 - Dung, N. V. A1 - Huttenlau, M. A1 - Achleitner, S. A1 - Stötter, J. A1 - Merz, Bruno A1 - Vorogushyn, Sergiy T1 - A continuous modelling approach for design flood estimation on sub-daily time scale JF - Hydrological sciences journal = Journal des sciences hydrologiques N2 - Design flood estimation is an essential part of flood risk assessment. Commonly applied are flood frequency analyses and design storm approaches, while the derived flood frequency using continuous simulation has been getting more attention recently. In this study, a continuous hydrological modelling approach on an hourly time scale, driven by a multi-site weather generator in combination with a -nearest neighbour resampling procedure, based on the method of fragments, is applied. The derived 100-year flood estimates in 16 catchments in Vorarlberg (Austria) are compared to (a) the flood frequency analysis based on observed discharges, and (b) a design storm approach. Besides the peak flows, the corresponding runoff volumes are analysed. The spatial dependence structure of the synthetically generated flood peaks is validated against observations. It can be demonstrated that the continuous modelling approach can achieve plausible results and shows a large variability in runoff volume across the flood events. KW - derived flood frequency KW - continuous modelling KW - temporal disaggregation KW - flood hazard KW - synthetic flood events Y1 - 2019 U6 - https://doi.org/10.1080/02626667.2019.1593419 SN - 0262-6667 SN - 2150-3435 VL - 64 IS - 5 SP - 539 EP - 554 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Eberli, Gregor P. A1 - Bernoulli, Daniel A1 - Vecsei, Adam A1 - Sekti, Rizky A1 - Grasmueck, Mark A1 - Lüdmann, Thomas A1 - Anselmetti, Flavio S. A1 - Mutti, Maria A1 - Della Porta, Giovanna T1 - A Cretaceous carbonate delta drift in the Montagna della Maiella, Italy JF - Sedimentology : the journal of the International Association of Sedimentologists N2 - The Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is compared to newly discovered contourite drifts in the Maldives. Like the drift deposits in the Maldives, the Orfento Formation fills a channel and builds a Miocene delta-shaped and mounded sedimentary body in the basin that is similar in size to the approximately 350 km(2) large coarse-grained bioclastic Miocene delta drifts in the Maldives. The composition of the bioclastic wedge of the Orfento Formation is also exclusively bioclastic debris sourced from the shallow-water areas and reworked clasts of the Orfento Formation itself. In the near mud-free succession, age-diagnostic fossils are sparse. The depositional textures vary from wackestone to float-rudstone and breccia/conglomerates, but rocks with grainstone and rudstone textures are the most common facies. In the channel, lensoid convex-upward breccias, cross-cutting channelized beds and thick grainstone lobes with abundant scours indicate alternating erosion and deposition from a high-energy current. In the basin, the mounded sedimentary body contains lobes with a divergent progradational geometry. The lobes are built by decametre thick composite megabeds consisting of sigmoidal clinoforms that typically have a channelized topset, a grainy foreset and a fine-grained bottomset with abundant irregular angular clasts. Up to 30 m thick channels filled with intraformational breccias and coarse grainstones pinch out downslope between the megabeds. In the distal portion of the wedge, stacked grainstone beds with foresets and reworked intraclasts document continuous sediment reworking and migration. The bioclastic wedge of the Orfento Formation has been variously interpreted as a succession of sea-level controlled slope deposits, a shoaling shoreface complex, or a carbonate tidal delta. Current-controlled delta drifts in the Maldives, however, offer a new interpretation because of their similarity in architecture and composition. These similarities include: (i) a feeder channel opening into the basin; (ii) an excavation moat at the exit of the channel; (iii) an overall mounded geometry with an apex that is in shallower water depth than the source channel; (iv) progradation of stacked lobes; (v) channels that pinch out in a basinward direction; and (vi) smaller channelized intervals that are arranged in a radial pattern. As a result, the Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is here interpreted as a carbonate delta drift. KW - Carbonate contourite drift KW - delta drift KW - Maiella Mountains KW - Orfento Formation KW - prograding lobes Y1 - 2019 U6 - https://doi.org/10.1111/sed.12590 SN - 0037-0746 SN - 1365-3091 VL - 66 IS - 4 SP - 1266 EP - 1301 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Zech, Alraune A1 - Attinger, Sabine A1 - Bellin, Alberto A1 - Cvetkovic, Vladimir A1 - Dietrich, Peter A1 - Fiori, Aldo A1 - Teutsch, Georg A1 - Dagan, Gedeon T1 - A Critical Analysis of Transverse Dispersivity Field Data JF - Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association N2 - Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio-degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error-prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field-scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation-specific, span three orders of magnitude and do not show any clear scale-dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity. Y1 - 2018 U6 - https://doi.org/10.1111/gwat.12838 SN - 0017-467X SN - 1745-6584 VL - 57 IS - 4 SP - 632 EP - 639 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Luetkecosmann, Steffi A1 - Faupel, Thomas A1 - Porstmann, Silvia A1 - Porstmann, Tomas A1 - Micheel, Burkhard A1 - Hanack, Katja T1 - A cross-reactive monoclonal antibody as universal detection antibody in autoantibody diagnostic assays JF - Clinica chimica acta N2 - Diagnostics of Autoimmune Diseases involve screening of patient samples for containing autoantibodies against various antigens. To ensure quality of diagnostic assays a calibrator is needed in each assay system. Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of polyclonal sera from other species. Nevertheless, the detection of human autoantibodies as well as the calibration reagent containing antibodies from other species in one assay constitutes a challenge in terms of assay calibration. We therefore developed a cross-reactive monoclonal antibody which binds human as well as rabbit sera with similar affinities in the nanomolar range. We tested our monoclonal antibody S38CD11B12 successfully in the commercial Serazym (R) Anti-Cardiolipin-beta 2-GPI IgG/IgM assay and could thereby prove the eligibility of S38CD11B12 as detection antibody in autoimmune diagnostic assays using rabbit derived sera as reference material. KW - Monoclonal antibody KW - Detection KW - Autoimmune diagnostics KW - Cross reactivity KW - Assay calibration Y1 - 2019 U6 - https://doi.org/10.1016/j.cca.2019.09.003 SN - 0009-8981 SN - 1873-3492 VL - 499 SP - 87 EP - 92 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Krentz, Konrad-Felix T1 - A Denial-of-Sleep-Resilient Medium Access Control Layer for IEEE 802.15.4 Networks T1 - Eine Denial-of-Sleep-Resiliente Mediumzugriffsschicht für IEEE-802.15.4-Netzwerke N2 - With the emergence of the Internet of things (IoT), plenty of battery-powered and energy-harvesting devices are being deployed to fulfill sensing and actuation tasks in a variety of application areas, such as smart homes, precision agriculture, smart cities, and industrial automation. In this context, a critical issue is that of denial-of-sleep attacks. Such attacks temporarily or permanently deprive battery-powered, energy-harvesting, or otherwise energy-constrained devices of entering energy-saving sleep modes, thereby draining their charge. At the very least, a successful denial-of-sleep attack causes a long outage of the victim device. Moreover, to put battery-powered devices back into operation, their batteries have to be replaced. This is tedious and may even be infeasible, e.g., if a battery-powered device is deployed at an inaccessible location. While the research community came up with numerous defenses against denial-of-sleep attacks, most present-day IoT protocols include no denial-of-sleep defenses at all, presumably due to a lack of awareness and unsolved integration problems. After all, despite there are many denial-of-sleep defenses, effective defenses against certain kinds of denial-of-sleep attacks are yet to be found. The overall contribution of this dissertation is to propose a denial-of-sleep-resilient medium access control (MAC) layer for IoT devices that communicate over IEEE 802.15.4 links. Internally, our MAC layer comprises two main components. The first main component is a denial-of-sleep-resilient protocol for establishing session keys among neighboring IEEE 802.15.4 nodes. The established session keys serve the dual purpose of implementing (i) basic wireless security and (ii) complementary denial-of-sleep defenses that belong to the second main component. The second main component is a denial-of-sleep-resilient MAC protocol. Notably, this MAC protocol not only incorporates novel denial-of-sleep defenses, but also state-of-the-art mechanisms for achieving low energy consumption, high throughput, and high delivery ratios. Altogether, our MAC layer resists, or at least greatly mitigates, all denial-of-sleep attacks against it we are aware of. Furthermore, our MAC layer is self-contained and thus can act as a drop-in replacement for IEEE 802.15.4-compliant MAC layers. In fact, we implemented our MAC layer in the Contiki-NG operating system, where it seamlessly integrates into an existing protocol stack. N2 - Mit dem Aufkommen des Internets der Dinge (IoT), werden immer mehr batteriebetriebene und energieerntende Geräte in diversen Anwendungsbereichen eingesetzt, etwa in der Heimautomatisierung, Präzisionslandwirtschaft, Industrieautomatisierung oder intelligenten Stadt. In diesem Kontext stellen sogenannte Denial-of-Sleep-Angriffe eine immer kritischer werdende Bedrohung dar. Solche Angriffe halten batteriebetriebene, energieerntende oder anderweitig energiebeschränkte Geräte zeitweise oder chronisch ab, in energiesparende Schlafmodi überzugehen. Erfolgreiche Denial-of-Sleep-Angriffe führen zumindest zu einer langen Ausfallzeit der betroffenen Geräte. Um betroffene batteriebetriebene Geräte wieder in Betrieb zu nehmen, müssen zudem deren Batterien gewechselt werden. Dies ist mühsam oder eventuell sogar unmöglich, z.B. wenn solche Geräte an unzugänglichen Orten installiert sind. Obwohl die Forschungsgemeinschaft bereits viele Denial-of-Sleep-Abwehrmechanismen vorgeschlagen hat, besitzen die meisten aktuellen IoT-Protokolle überhaupt keine Denial-of-Sleep-Abwehrmechanismen. Dies kann zum einen daran liegen, dass man des Problems noch nicht gewahr ist, aber zum anderen auch daran, dass viele Integrationsfragen bislang ungeklärt sind. Des Weiteren existieren bisher sowieso noch keine effektiven Abwehrmechanismen gegen bestimmte Denial-of-Sleep-Angriffe. Der Hauptbeitrag dieser Dissertation ist die Entwicklung einer Denial-of-Sleep-resilienten Mediumzugriffsschicht für IoT-Geräte, die via IEEE-802.15.4-Funkverbindungen kommunizieren. Die entwickelte Mediumzugriffsschicht besitzt zwei Hauptkomponenten. Die erste Hauptkomponente ist ein Denial-of-Sleep-resilientes Protokoll zur Etablierung von Sitzungsschlüsseln zwischen benachbarten IEEE-802.15.4-Knoten. Diese Sitzungsschlüssel dienen einerseits der grundlegenden Absicherung des Funkverkehrs und andererseits der Implementierung zusätzlicher Denial-of-Sleep-Abwehrmechanismen in der zweiten Hauptkomponente. Die zweite Hauptkomponente ist ein Denial-of-Sleep-resilientes Mediumzugriffsprotokoll. Bemerkenswert an diesem Mediumzugriffsprotokoll ist, dass es nicht nur neuartige Denial-of-Sleep-Abwehrmechanismen enthält, sondern auch dem Stand der Technik entsprechende Mechanismen zur Verringerung des Energieverbrauchs, zur Steigerung des Durchsatzes sowie zur Erhöhung der Zuverlässigkeit. Zusammenfassend widersteht bzw. mildert unsere Denial-of-Sleep-resiliente Mediumzugriffsschicht alle uns bekannten Denial-of-Sleep-Angriffe, die gegen sie gefahren werden können. Außerdem kann unsere Denial-of-Sleep-resiliente Mediumzugriffsschicht ohne Weiteres an Stelle von IEEE-802.15.4-konformen Mediumzugriffsschichten eingesetzt werden. Dies zeigen wir durch die nahtlose Integration unserer Mediumzugriffsschicht in den Netzwerk-Stack des Betriebssystems Contiki-NG. KW - medium access control KW - denial of sleep KW - internet of things KW - Mediumzugriffskontrolle KW - Schlafentzugsangriffe KW - Internet der Dinge Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-439301 ER - TY - JOUR A1 - Demal, Till Joscha A1 - Heise, Melina A1 - Reiz, Benedikt A1 - Dogra, Deepika A1 - Braenne, Ingrid A1 - Reichenspurner, Hermann A1 - Männer, Jörg A1 - Aherrahrou, Zouhair A1 - Schunkert, Heribert A1 - Erdmann, Jeanette A1 - Abdelilah-Seyfried, Salim T1 - A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A JF - Scientific reports N2 - The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein’s anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-39648-7 SN - 2045-2322 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Alexiadou, Artemis T1 - A form-function mismatch? BT - The case of Greek deponents JF - Of trees and birds. A Festschrift for Gisbert Fanselow KW - Festschrift KW - Informationsstruktur KW - Linguistik KW - Morphologie KW - Syntax KW - festschrift KW - information structure KW - linguistics KW - morphology KW - syntax Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432235 SN - 978-3-86956-457-9 SP - 107 EP - 117 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Emuoyibofarhe, Justice O. A1 - Akindele, Akinyinka Tosin A1 - Ronke, Babatunde Seyi A1 - Omotosho, Adebayo A1 - Meinel, Christoph T1 - A Fuzzy Rule-Based Model for Remote Monitoring of Preterm in the Intensive Care Unit of Hospitals JF - International Journal of Medical Research & Health Sciences N2 - The use of Remote patient monitoring (RPM) systems to monitor critically ill patients in the Intensive Care Unit (ICU) has enabled quality and real-time healthcare management. Fuzzy logic as an approach to designing RPM systems provides a means for encapsulating the subjective decision-making process of medical experts in an algorithm suitable for computer implementation. In this paper, a remote monitoring system for preterm in neonatal ICU incubators is modeled and simulated. The model was designed with 4 input variables (body temperature, heart rate, respiratory rate, and oxygen level saturation), and 1 output variable (action performed represented as ACT). ACT decides whether-an alert is generated or not and also determines the message displayed when a notification is required. ACT classifies the clinical priority of the monitored preterm into 5 different fields: code blue, code red, code yellow, code green, and-code black. The model was simulated using a fuzzy logic toolbox of MATLAB R2015A. About 216 IF_THEN rules were formulated to monitor the inputs data fed into the model. The performance of the model was evaluated using-the confusion matrix to determine the model’s accuracy, precision, sensitivity, specificity, and false alarm rate. The-experimental results obtained shows that the fuzzy-based system is capable of producing satisfactory results when used for monitoring and classifying the clinical statuses of neonates in ICU incubators. KW - Remote patient monitoring KW - Fuzzy logic KW - Preterm KW - Incubator KW - Confusion matrix Y1 - 2019 SN - 2319-5886 VL - 8 IS - 5 SP - 33 EP - 44 PB - Sumathi CY - Trichy ER - TY - JOUR A1 - Lontsi, Agostiny Marrios A1 - Garcia-Jerez, Antonio A1 - Camilo Molina-Villegas, Juan A1 - Jose Sanchez-Sesma, Francisco A1 - Molkenthin, Christian A1 - Ohrnberger, Matthias A1 - Krüger, Frank A1 - Wang, Rongjiang A1 - Fah, Donat T1 - A generalized theory for full microtremor horizontal-to-vertical [H/V(z,f)] spectral ratio interpretation in offshore and onshore environments JF - Geophysical journal international N2 - Advances in the field of seismic interferometry have provided a basic theoretical interpretation to the full spectrum of the microtremor horizontal-to-vertical spectral ratio [H/V(f)]. The interpretation has been applied to ambient seismic noise data recorded both at the surface and at depth. The new algorithm, based on the diffuse wavefield assumption, has been used in inversion schemes to estimate seismic wave velocity profiles that are useful input information for engineering and exploration seismology both for earthquake hazard estimation and to characterize surficial sediments. However, until now, the developed algorithms are only suitable for on land environments with no offshore consideration. Here, the microtremor H/V(z, f) modelling is extended for applications to marine sedimentary environments for a 1-D layered medium. The layer propagator matrix formulation is used for the computation of the required Green’s functions. Therefore, in the presence of a water layer on top, the propagator matrix for the uppermost layer is defined to account for the properties of the water column. As an application example we analyse eight simple canonical layered earth models. Frequencies ranging from 0.2 to 50 Hz are considered as they cover a broad wavelength interval and aid in practice to investigate subsurface structures in the depth range from a few meters to a few hundreds of meters. Results show a marginal variation of 8 per cent at most for the fundamental frequency when a water layer is present. The water layer leads to variations in H/V peak amplitude of up to 50 per cent atop the solid layers. KW - Numerical modelling KW - Earthquake hazards KW - Seismic interferometry KW - Site effects KW - Theoretical seismology KW - Wave propagation Y1 - 2019 U6 - https://doi.org/10.1093/gji/ggz223 SN - 0956-540X SN - 1365-246X VL - 218 IS - 2 SP - 1276 EP - 1297 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Beisner, Beatrix E. A1 - Grossart, Hans-Peter A1 - Gasol, Josep M. T1 - A guide to methods for estimating phago-mixotrophy in nanophytoplankton JF - Journal of plankton research N2 - Growing attention to phytoplankton mixotrophy as a trophic strategy has led to significant revisions of traditional pelagic food web models and ecosystem functioning. Although some empirical estimates of mixotrophy do exist, a much broader set of in situ measurements are required to (i) identify which organisms are acting as mixotrophs in real time and to (ii) assess the contribution of their heterotrophy to biogeochemical cycling. Estimates are needed through time and across space to evaluate which environmental conditions or habitats favour mixotrophy: conditions still largely unknown. We review methodologies currently available to plankton ecologists to undertake estimates of plankton mixotrophy, in particular nanophytoplankton phago-mixotrophy. Methods are based largely on fluorescent or isotopic tracers, but also take advantage of genomics to identify phylotypes and function. We also suggest novel methods on the cusp of use for phago-mixotrophy assessment, including single-cell measurements improving our capacity to estimate mixotrophic activity and rates in wild plankton communities down to the single-cell level. Future methods will benefit from advances in nanotechnology, micromanipulation and microscopy combined with stable isotope and genomic methodologies. Improved estimates of mixotrophy will enable more reliable models to predict changes in food web structure and biogeochemical flows in a rapidly changing world. KW - flow cytometry KW - phagotrophy KW - phytoplankton KW - methods KW - fluorescence KW - microscopy KW - FISH KW - isotopic methods KW - phylotypes KW - carbon flows KW - gene sequencing Y1 - 2019 U6 - https://doi.org/10.1093/plankt/fbz008 SN - 0142-7873 SN - 1464-3774 VL - 41 IS - 2 SP - 77 EP - 89 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Myachykov, Andriy A1 - Fischer, Martin H. T1 - A hierarchical view of abstractness BT - Grounded, embodied, and situated aspect: Comment on "Words as social tools: Language, sociality and inner grounding in abstract concepts" by Anna M. Borghi et al. T2 - Physics of life reviews Y1 - 2019 U6 - https://doi.org/10.1016/j.plrev.2019.04.005 SN - 1571-0645 SN - 1873-1457 VL - 29 SP - 161 EP - 163 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Jantzen, Friederike A1 - Wozniak, Natalia Joanna A1 - Kappel, Christian A1 - Sicard, Adrien A1 - Lenhard, Michael T1 - A high‑throughput amplicon‑based method for estimating outcrossing rates T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming. Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd’s Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons. Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 745 KW - Outcrossing KW - Mixed mating KW - Outcrossing rate KW - Capsella KW - Amplicon sequencing Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435657 SN - 1866-8372 IS - 745 ER - TY - JOUR A1 - Jantzen, Friederike A1 - Wozniak, Natalia Joanna A1 - Kappel, Christian A1 - Sicard, Adrien A1 - Lenhard, Michael T1 - A high‑throughput amplicon‑based method for estimating outcrossing rates JF - Plant Methods N2 - Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming. Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd’s Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons. Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing. KW - Outcrossing KW - Mixed mating KW - Outcrossing rate KW - Capsella KW - Amplicon sequencing Y1 - 2019 U6 - https://doi.org/10.1186/s13007-019-0433-9 SN - 1746-4811 VL - 15 IS - 47 PB - BioMed Central CY - London ER - TY - GEN A1 - Gonzalez-Lopez, Fernanda A1 - Pufahl, Luise T1 - A Landscape for Case Models T2 - Enterprise, Business-Process and Information Systems Modeling N2 - Case Management is a paradigm to support knowledge-intensive processes. The different approaches developed for modeling these types of processes tend to result in scattered models due to the low abstraction level at which the inherently complex processes are therein represented. Thus, readability and understandability is more challenging than that of traditional process models. By reviewing existing proposals in the field of process overviews and case models, this paper extends a case modeling language - the fragment-based Case Management (fCM) language - with the goal of modeling knowledge-intensive processes from a higher abstraction level - to generate a so-called fCM landscape. This proposal is empirically evaluated via an online experiment. Results indicate that interpreting an fCM landscape might be more effective and efficient than interpreting an informationally equivalent case model. KW - Case Management KW - Process landscape KW - Process map KW - Process architecture KW - Process model Y1 - 2019 SN - 978-3-030-20618-5 SN - 978-3-030-20617-8 U6 - https://doi.org/10.1007/978-3-030-20618-5_6 SN - 1865-1348 VL - 352 SP - 87 EP - 102 PB - Springer CY - Berlin ER - TY - BOOK A1 - Schneider, Sven A1 - Lambers, Leen A1 - Orejas, Fernando T1 - A logic-based incremental approach to graph repair T1 - Ein logikbasierter inkrementeller Ansatz für Graphreparatur N2 - Graph repair, restoring consistency of a graph, plays a prominent role in several areas of computer science and beyond: For example, in model-driven engineering, the abstract syntax of models is usually encoded using graphs. Flexible edit operations temporarily create inconsistent graphs not representing a valid model, thus requiring graph repair. Similarly, in graph databases—managing the storage and manipulation of graph data—updates may cause that a given database does not satisfy some integrity constraints, requiring also graph repair. We present a logic-based incremental approach to graph repair, generating a sound and complete (upon termination) overview of least-changing repairs. In our context, we formalize consistency by so-called graph conditions being equivalent to first-order logic on graphs. We present two kind of repair algorithms: State-based repair restores consistency independent of the graph update history, whereas deltabased (or incremental) repair takes this history explicitly into account. Technically, our algorithms rely on an existing model generation algorithm for graph conditions implemented in AutoGraph. Moreover, the delta-based approach uses the new concept of satisfaction (ST) trees for encoding if and how a graph satisfies a graph condition. We then demonstrate how to manipulate these STs incrementally with respect to a graph update. N2 - Die Reparatur von Graphen, die Wiederherstellung der Konsistenz eines Graphen, spielt in mehreren Bereichen der Informatik und darüber hinaus eine herausragende Rolle: Beispielsweise wird in der modellgetriebenen Konstruktion die abstrakte Syntax von Modellen in der Regel mithilfe von Graphen kodiert. Flexible Bearbeitungsvorgänge erstellen vorübergehend inkonsistente Diagramme, die kein gültiges Modell darstellen, und erfordern daher eine Reparatur des Diagramms. Auf ähnliche Weise können Aktualisierungen in Graphendatenbanken - die das Speichern und Bearbeiten von Graphendaten verwalten - dazu führen, dass eine bestimmte Datenbank einige Integritätsbeschränkungen nicht erfüllt und auch eine Graphreparatur erforderlich macht. Wir präsentieren einen logikbasierten inkrementellen Ansatz für die Graphreparatur, der eine solide und vollständige (nach Beendigung) Übersicht über die am wenigsten verändernden Reparaturen erstellt. In unserem Kontext formalisieren wir die Konsistenz mittels sogenannten Graphbedingungen die der Logik erster Ordnung in Graphen entsprechen. Wir stellen zwei Arten von Reparaturalgorithmen vor: Die zustandsbasierte Reparatur stellt die Konsistenz unabhängig vom Verlauf der Graphänderung wieder her, während die deltabasierte (oder inkrementelle) Reparatur diesen Verlauf explizit berücksichtigt. Technisch stützen sich unsere Algorithmen auf einen vorhandenen Modellgenerierungsalgorithmus für in AutoGraph implementierte Graphbedingungen. Darüber hinaus verwendet der deltabasierte Ansatz das neue Konzept der Erfüllungsbäume (STs) zum Kodieren, ob und wie ein Graph eine Graphbedingung erfüllt. Wir zeigen dann, wie diese STs in Bezug auf eine Graphaktualisierung inkrementell manipuliert werden. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 126 KW - nested graph conditions KW - graph repair KW - model repair KW - consistency restoration KW - verschachtelte Graphbedingungen KW - Graphreparatur KW - Modellreparatur KW - Konsistenzrestauration Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427517 SN - 978-3-86956-462-3 SN - 1613-5652 SN - 2191-1665 IS - 126 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Scheffler, Franziska A1 - Immenhauser, Adrian A1 - Pourteau, Amaury A1 - Natalicchio, Marcello A1 - Candan, Osman A1 - Oberhänsli, Roland T1 - A lost Tethyan evaporitic basin BT - Evidence from a Cretaceous hemipelagic meta-selenite - red chert association in the Eastern Mediterranean realm JF - Sedimentology : the journal of the International Association of Sedimentologists N2 - Ancient evaporite deposits are geological archives of depositional environments characterized by a long‐term negative precipitation balance and bear evidence for global ocean element mass balance calculations. Here, Cretaceous selenite pseudomorphs from western Anatolia (‘Rosetta Marble’) — characterized by their exceptional morphological preservation — and their ‘marine’ geochemical signatures are described and interpreted in a process‐oriented context. These rocks recorded Late Cretaceous high‐pressure/low‐temperature, subduction‐related metamorphism with peak conditions of 1·0 to 1·2 GPa and 300 to 400°C. Metre‐scale, rock‐forming radiating rods, now present as fibrous calcite marble, clearly point to selenitic gypsum as the precursor mineral. Stratigraphic successions are recorded along a reconstructed proximal to distal transect. The cyclical alternation of selenite beds and radiolarian ribbon‐bedded cherts in the distal portions are interpreted as a two type of seawater system. During arid intervals, shallow marine brines cascaded downward into basinal settings and induced precipitation. During more humid times, upwelling‐induced radiolarian blooms caused the deposition of radiolarite facies. Interestingly, there is no comparable depositional setting known from the Cenozoic world. Meta‐selenite geochemical data (δ13C, δ18O and 87Sr/86Sr) plot within the range of reconstructed middle Cretaceous seawater signatures. Possible sources for the 13C‐enriched (mean 2·2‰) values include methanogenesis, gas hydrates and cold seep fluid exhalation. Spatially resolved component‐specific analysis of a rock slab displays isotopic variances between meta‐selenite crystals (mean δ13C 2·2‰) and host matrix (mean δ13C 1·3‰). The Cretaceous evaporite‐pseudomorphs of Anatolia represent a basin wide event coeval with the Aptian evaporites of the Proto‐Atlantic and the pseudomorphs share many attributes, including lateral distribution of 600 km and stratigraphic thickness of 1·5 to 2·0 km, with the evaporites formed during the younger Messinian salinity crisis. The Rosetta Marble of Anatolia may represent the best‐preserved selenite pseudomorphs worldwide and have a clear potential to act as a template for the study of meta‐selenite in deep time. KW - Blueschist metamorphism KW - depositional environment KW - evaporites KW - Neotethys KW - pseudomorphism KW - sedimentology Y1 - 2019 U6 - https://doi.org/10.1111/sed.12606 SN - 0037-0746 SN - 1365-3091 VL - 66 IS - 7 SP - 2627 EP - 2660 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Schiro, Gabriele A1 - Colangeli, Pierluigi A1 - Müller, Marina E. H. T1 - A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field JF - Frontiers in microbiology KW - Fusarium KW - microclimate KW - canopy KW - fungal community KW - Alternaria KW - spatially induced variance Y1 - 2019 U6 - https://doi.org/10.3389/fmicb.2019.02095 SN - 1664-302X VL - 10 PB - Frontiers Research Foundation CY - Lausanne ER -