TY - JOUR A1 - Wuennemann, Patrick A1 - Noyong, Michael A1 - Kreuels, Klaus A1 - Bruex, Roland A1 - Gordiichuk, Pavlo A1 - van Rijn, Patrick A1 - Plamper, Felix A. A1 - Simon, Ulrich A1 - Böker, Alexander T1 - Microstructured Hydrogel Templates for the Formation of Conductive Gold Nanowire Arrays JF - Macromolecular rapid communications N2 - Microstructured hydrogel allows for a new template-guided method to obtain conductive nanowire arrays on a large scale. To generate the template, an imprinting process is used in order to synthesize the hydrogel directly into the grooves of wrinkled polydimethylsiloxane (PDMS). The resulting poly(N-vinylimidazole)-based hydrogel is defined by the PDMS stamp in pattern and size. Subsequently, tetrachloroaurate(III) ions from aqueous solution are coordinated within the humps of the N-vinylimidazole-containing polymer template and reduced by air plasma. After reduction and development of the gold, to achieve conductive wires, the extension perpendicular to the long axis (width) of the gold strings is considerably reduced compared to the dimension of the parental hydrogel wrinkles (from approximate to 1 mu m down to 200-300 nm). At the same time, the wire-to-wire distance and the overall length of the wires is preserved. The PDMS templates and hydrogel structures are analyzed with scanning force microscopy (SFM) and the gold structures via scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The conductivity measurements of the gold nanowires are performed in situ in the SEM, showing highly conductive gold leads. Hence, this method can be regarded as a facile nonlithographic top-down approach from micrometer-sized structures to nanometer-sized features. KW - 1D structures KW - Au nanoarrays KW - microgel KW - nanoimprint KW - lithography KW - thin films Y1 - 2016 U6 - https://doi.org/10.1002/marc.201600287 SN - 1022-1336 SN - 1521-3927 VL - 37 SP - 1446 EP - 1452 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wessig, Pablo A1 - Behrends, Nicole A1 - Kumke, Michael Uwe A1 - Eisold, Ursula T1 - FRET Pairs with Fixed Relative Orientation of Chromophores JF - European journal of organic chemistry N2 - Synthetic routes to different oligospirothioketal (OSTK) Forster resonance energy transfer (FRET) constructs are described and the photophysics of these constructs were explored in different solvents. The FRET efficiencies were determined from the experimental data and compared with theoretical values. The influence of the outstanding rigidity of the novel OSTK compounds on the FRET is discussed. KW - Fluorescence KW - Energy transfer KW - FRET KW - Chromophores KW - Spiro compounds Y1 - 2016 U6 - https://doi.org/10.1002/ejoc.201600489 SN - 1434-193X SN - 1099-0690 VL - 145 SP - 4476 EP - 4486 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kovach, Ildiko A1 - Rumschöttel, Jens A1 - Friberg, Stig E. A1 - Koetz, Joachim T1 - Janus emulsion mediated porous scaffold bio-fabrication JF - Colloids and surfaces : an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin ; B, Biointerfaces N2 - A three dimensional biopolymer network structure with incorporated nano-porous calcium phosphate (CaP) balls was fabricated by using gelatin-chitosan (GC) polymer blend and GC stabilized olive/silicone oil Janus emulsions, respectively. The emulsions were freeze-dried, and the oil droplets were washed out in order to prepare porous scaffolds with larger surface area. The morphology, pore size, chemical composition, thermal and swelling behavior was studied by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and micro-Differential Scanning Calorimetry (micro-DSC). Microscopic analysis confirmed that the pore size of the GC based sponges after freeze-drying may be drastically reduced by using Janus emulsions. Besides, the incorporation of nanoporous calcium phosphate balls is also lowering the pore size and enhancing thermal stability. (C) 2016 Elsevier B.V. All rights reserved. KW - Janus emulsions KW - Calcium phosphates KW - Gelatin-chitosan scaffolds Y1 - 2016 U6 - https://doi.org/10.1016/j.colsurfb.2016.05.018 SN - 0927-7765 SN - 1873-4367 VL - 145 SP - 347 EP - 352 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Höse, Anna A1 - Wyschkon, Anne A1 - Moraske, Svenja A1 - Eggeling, Marie A1 - Quandte, Sabine A1 - Kohn, Juliane A1 - Poltz, Nadine A1 - von Aster, Michael G. A1 - Esser, Günter T1 - Prevention of dyslexia short-term and intermediate effects of promoting phonological awareness and letter-sound correspondence with at-risk preschool children JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie N2 - Objective: This study assesses the short-term and intermediate effects of preschool training stimulating phonological awareness and letter-sound correspondence for children at risk of developing dyslexia. Moreover, we examined whether training reduced the frequency of subsequent dyslexic problems. Method: 25 children at risk of developing dyslexia were trained with Horen, Lauschen, Lernen 1 und 2 (Kuspert & Schneider, 2008; Plume & Schneider, 2004) by their kindergarten teachers and were compared with 60 untrained at-risk children. Results:The training revealed a significant short-term effect: The phonological awareness of trained at-risk children increased significantly over that of untrained at-risk children. However, there were no differences in phonological awareness, spelling, and reading ability between the first-graders in the training and control group. Furthermore, reading problems were reduced in the training group. Conclusions: In the future, phonological awareness as well as additional predictors should be included when identifying children vulnerable to developing dyslexia. Moreover, in order to prevent dyslexia, additional prerequisite deficits need to be identified, alleviated, and their effects evaluated. KW - developmental dyslexia KW - phonological awareness KW - prevention KW - risk KW - specific developmental disorder Y1 - 2016 U6 - https://doi.org/10.1024/1422-4917/a000456 SN - 1422-4917 SN - 1664-2880 VL - 44 SP - 377 EP - 391 PB - Hogrefe CY - Bern ER - TY - JOUR A1 - Heinz, A. A1 - Voss, M. A1 - Lawrie, S. M. A1 - Mishara, A. A1 - Bauer, M. A1 - Gallinat, Jürgen A1 - Juckel, G. A1 - Lang, U. A1 - Rapp, Michael A. A1 - Falkai, P. A1 - Strik, W. A1 - Krystal, J. A1 - Abi-Dargham, A. A1 - Galderisi, S. T1 - Shall we really say goodbye to first rank symptoms? JF - European psychiatry : the journal of the Association of European Psychiatrists N2 - Background: First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A' symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10 is currently under revision and may follow suit. In this review, we discuss central points of criticism that are directed against the continuous use of first rank symptoms (FRS) to diagnose schizophrenia. KW - First rank symptoms KW - Schizophrenia KW - ICD KW - DSM KW - Self-disorder Y1 - 2016 U6 - https://doi.org/10.1016/j.eurpsy.2016.04.010 SN - 0924-9338 SN - 1778-3585 VL - 37 SP - 8 EP - 13 PB - Elsevier CY - Paris ER - TY - JOUR A1 - Gebser, Martin A1 - Schaub, Torsten H. T1 - Modeling and Language Extensions JF - AI magazine N2 - Answer set programming (ASP) has emerged as an approach to declarative problem solving based on the stable model semantics for logic programs. The basic idea is to represent a computational problem by a logic program, formulating constraints in terms of rules, such that its answer sets correspond to problem solutions. To this end, ASP combines an expressive language for high-level modeling with powerful low-level reasoning capacities, provided by off-the-shelf tools. Compact problem representations take advantage of genuine modeling features of ASP, including (first-order) variables, negation by default, and recursion. In this article, we demonstrate the ASP methodology on two example scenarios, illustrating basic as well as advanced modeling and solving concepts. We also discuss mechanisms to represent and implement extended kinds of preferences and optimization. An overview of further available extensions concludes the article. Y1 - 2016 SN - 0738-4602 VL - 37 SP - 33 EP - 44 PB - Association for the Advancement of Artificial Intelligence CY - Menlo Park ER - TY - JOUR A1 - Kaufmann, Benjamin A1 - Leone, Nicola A1 - Perri, Simona A1 - Schaub, Torsten H. T1 - Grounding and Solving in Answer Set Programming JF - AI magazine N2 - Answer set programming is a declarative problem-solving paradigm that rests upon a work flow involving modeling, grounding, and solving. While the former is described by Gebser and Schaub (2016), we focus here on key issues in grounding, or how to systematically replace object variables by ground terms in an effective way, and solving, or how to compute the answer sets, of a propositional logic program obtained by grounding. Y1 - 2016 SN - 0738-4602 VL - 37 SP - 25 EP - 32 PB - Association for the Advancement of Artificial Intelligence CY - Menlo Park ER - TY - JOUR A1 - Malinowski, Radostaw A1 - Höfle, Bernhard A1 - Koenig, Kristina A1 - Groom, Geoff A1 - Schwanghart, Wolfgang A1 - Heckrath, Goswin T1 - Local-scale flood mapping on vegetated floodplains from radiometrically calibrated airborne LiDAR data JF - ISPRS journal of photogrammetry and remote sensing : official publication of the International Society for Photogrammetry and Remote Sensing N2 - Knowledge about the magnitude of localised flooding of riverine areas is crucial for appropriate land management and administration at regional and local levels. However, detection and delineation of localised flooding with remote sensing techniques are often hampered on floodplains by the presence of herbaceous vegetation. To address this problem, this study presents the application of full waveform airborne laser scanning (ALS) data for detection of floodwater extent. In general, water surfaces are characterised by low values of backscattered energy due to water absorption of the infrared laser shots, but the exact strength of the recorded laser pulse depends on the area covered by the targets located within a laser pulse footprint area. To account for this we analysed the physical quantity of radio metrically calibrated ALS data, the backscattering coefficient, in relation to water and vegetation coverage within a single laser footprint. The results showed that the backscatter was negatively correlated to water coverage, and that of the three distinguished classes of water coverage (low, medium, and high) only the class with the largest extent of water cover (>70%) had relatively distinct characteristics that can be used for classification of water surfaces. Following the laser footprint analysis, three classifiers, namely AdaBoost with Decision Tree, Naive Bayes and Random Forest, were utilised to classify laser points into flooded and non-flooded classes and to derive the map of flooding extent. The performance of the classifiers is highly dependent on the set of laser points features used. Best performance was achieved by combining radiometric and geometric laser point features. The accuracy of flooding maps based solely on radiometric features resulted in overall accuracies of up to 70% and was limited due to the overlap of the backscattering coefficient values between water and other land cover classes. Our point-based classification methods assure a high mapping accuracy (similar to 89%) and demonstrate the potential of using full-waveform ALS data to detect water surfaces on floodplain areas with limited water surface exposition through the vegetation canopy. (C) 2016 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved. KW - ALS KW - LiDAR KW - Point cloud KW - Inundation KW - Full-waveform KW - Water Y1 - 2016 U6 - https://doi.org/10.1016/j.isprsjprs.2016.06.009 SN - 0924-2716 SN - 1872-8235 VL - 119 SP - 267 EP - 279 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bhatara, Anjali A1 - Boll-Avetisyan, Natalie A1 - Agus, Trevor A1 - Höhle, Barbara A1 - Nazzi, Thierry T1 - Language Experience Affects Grouping of Musical Instrument Sounds JF - Cognitive science : a multidisciplinary journal of anthropology, artificial intelligence, education, linguistics, neuroscience, philosophy, psychology ; journal of the Cognitive Science Society KW - Cross-linguistic KW - French KW - German KW - Auditory perception KW - Music KW - Rhythmic grouping Y1 - 2016 U6 - https://doi.org/10.1111/cogs.12300 SN - 0364-0213 SN - 1551-6709 VL - 40 SP - 1816 EP - 1830 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Garoufi, Konstantina A1 - Staudte, Maria A1 - Koller, Alexander A1 - Crocker, Matthew W. T1 - Exploiting Listener Gaze to Improve Situated Communication in Dynamic Virtual Environments JF - Cognitive science : a multidisciplinary journal of anthropology, artificial intelligence, education, linguistics, neuroscience, philosophy, psychology ; journal of the Cognitive Science Society N2 - Beyond the observation that both speakers and listeners rapidly inspect the visual targets of referring expressions, it has been argued that such gaze may constitute part of the communicative signal. In this study, we investigate whether a speaker may, in principle, exploit listener gaze to improve communicative success. In the context of a virtual environment where listeners follow computer-generated instructions, we provide two kinds of support for this claim. First, we show that listener gaze provides a reliable real-time index of understanding even in dynamic and complex environments, and on a per-utterance basis. Second, we show that a language generation system that uses listener gaze to provide rapid feedback improves overall task performance in comparison with two systems that do not use gaze. Aside from demonstrating the utility of listener gaze insituated communication, our findings open the door to new methods for developing and evaluating multi-modal models of situated interaction. KW - Listener gaze KW - Eye-tracking KW - Referential understanding KW - Virtual environments KW - Situated communication Y1 - 2016 U6 - https://doi.org/10.1111/cogs.12298 SN - 0364-0213 SN - 1551-6709 VL - 40 SP - 1671 EP - 1703 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Balci, K. A1 - Akkaya, Y. A1 - Akyuz, S. A1 - Collier, W. B. A1 - Stricker, M. C. A1 - Stover, D. D. A1 - Ritzhaupt, G. A1 - Koch, Andreas A1 - Kleinpeter, Erich T1 - The effects of conformation and zwitterionic tautomerism on the structural and vibrational spectral data of anserine JF - Vibrational spectroscopy : an international journal devoted to applications of infrared and raman spectroscopy N2 - In this study, the stable conformers of neutral anserine were searched by molecular dynamics simulations and energy minimization calculations using the MM2 force field. Thermochemical calculations at B3LYP/6-31G(d) level of theory followed these preliminary calculations. The results confirmed that neutral anserine has quite a flexible structure and many stable gauche and trans conformers at room temperature. Nevertheless, two are considerably more favourable in energy than the others and expected to dominate the gas-phase and matrix IR spectra of the molecule. The corresponding structural and vibrational spectral data for these two conformers of neutral anserine, whose relative stabilities were also examined by high-accuracy energy calculations carried out using G3MP2B3 method, and for the most stable conformer of anserine in zwitterion form were calculated at B3LYP/6-311++G(d,p) level of theory. The calculated harmonic force constants were refined using the Scaled Quantum Mechanical Force Field (SQM-FF) method and then used to produce the refined wavenumbers, potential energy distributions (PEDs) and IR and Raman intensities. These refined data together with the scaled harmonic wavenumbers obtained using another method, Dual Scale factors (DS), enabled us to correctly analyse the observed IR and Raman spectra of anserine and revealed the effects of conformation and zwitterionic tautomerism on its structural and vibrational spectral data. (C) 2016 Elsevier B.V. All rights reserved. KW - Anserine KW - Matrix IR spectrum KW - Tautomerism KW - SQM-FF KW - Dual scale factors Y1 - 2016 U6 - https://doi.org/10.1016/j.vibspec.2016.08.003 SN - 0924-2031 SN - 1873-3697 VL - 86 SP - 277 EP - 289 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Schernthaner, G. A1 - Groop, P. A1 - Cooper, M. A1 - Perkovic, V A1 - Hocher, Berthold A1 - Kanasaki, K. A1 - Sharma, K. A1 - Stanton, R. A1 - Toto, R. A1 - Cescutti, Jessica A1 - Gordat, M. A1 - Meinicke, T. A1 - Koitka-Weber, A. A1 - Woerle, H. A1 - Eynatten, M. T1 - EFFECTS OF LINAGLIPTIN ON GLYCAEMIC CONTROL AND ALBUMINURIA IN TYPE 2 DIABETES - THE MARLINA-T2D (TM) TRIAL T2 - Nephrology Y1 - 2016 U6 - https://doi.org/10.1111/nep.12887 SN - 1320-5358 SN - 1440-1797 VL - 21 SP - 60 EP - 60 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Keller, Matthias A1 - Münch, Florentin A1 - Pogorzelski, Felix T1 - Geometry and spectrum of rapidly branching graphs JF - Mathematische Nachrichten N2 - We study graphs whose vertex degree tends to infinity and which are, therefore, called rapidly branching. We prove spectral estimates, discreteness of spectrum, first order eigenvalue and Weyl asymptotics solely in terms of the vertex degree growth. The underlying techniques are estimates on the isoperimetric constant. Furthermore, we give lower volume growth bounds and we provide a new criterion for stochastic incompleteness. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim KW - Graph Laplacians KW - discrete spectrum KW - eigenvalue asymptotics KW - isoperimetric estimates KW - stochastic completeness Y1 - 2016 U6 - https://doi.org/10.1002/mana.201400349 SN - 0025-584X SN - 1522-2616 VL - 289 SP - 1636 EP - 1647 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Drosselmeyer, J. A1 - Rapp, Michael A. A1 - Hadji, P. A1 - Kostev, K. T1 - Depression risk in female patients with osteoporosis in primary care practices in Germany JF - Osteoporosis international N2 - The Summary Thirty-five thousand four hundred eighty-three female osteoporosis patients were compared with 35,483 patients without osteoporosis regarding the incidence of depression. The risk of depression is significantly increased for patients with osteoporosis compared with patients without osteoporosis in primary care practices within Germany. Introduction The objectives of the present study were to analyze the incidence of depression in German female patients with osteoporosis and to evaluate the risk factors for depression diagnosis within this patient population. Methods This study was a retrospective database analysis conducted in Germany utilizing the Disease Analyzer (R) Database (IMS Health, Germany). The study population included 70,966 patients between 40 and 80 years of age from 1072 primary care practices. The observation period was between 2004 and 2013. Follow-up duration was 5 years and was completed in April 2015. A total of 35,483 osteoporosis patients were selected after applying exclusion criteria, and 35,483 controls were chosen and then matched (1:1) to osteoporosis patients based on age, sex, health insurance coverage, depression diagnosis in the past, and follow-up duration after index date. The analyses of depression-free survival were carried out using Kaplan-Meier curves and log-rank tests. Cox proportional hazards models (dependent variable: depression) were used to adjust for confounders. Results Depression diagnoses were presented in 33.0% of the osteoporosis group and 22.7% of the control group after the 5-year follow-up (p < 0.001). Dementia, cancer, heart failure, coronary heart disease, and diabetes were associated with a higher risk of developing depression (p < 0.001). Private health insurance was associated with a lower risk of depression. There was no significant effect of fractures on depression risk. Conclusion The risk of depression is significantly increased for patients with osteoporosis in primary care practices within Germany. KW - Comorbidity KW - Depression risk KW - Osteoporosis KW - Primary care practice Y1 - 2016 U6 - https://doi.org/10.1007/s00198-016-3584-9 SN - 0937-941X SN - 1433-2965 VL - 27 SP - 2739 EP - 2744 PB - Springer CY - London ER - TY - JOUR A1 - Shprits, Yuri Y. A1 - Drozdov, Alexander A1 - Spasojevic, Maria A1 - Kellerman, Adam C. A1 - Usanova, Maria E. A1 - Engebretson, Mark J. A1 - Agapitov, Oleksiy V. A1 - Zhelavskaya, Irina A1 - Raita, Tero J. A1 - Spence, Harlan E. A1 - Baker, Daniel N. A1 - Zhu, Hui A1 - Aseev, Nikita T1 - Wave-induced loss of ultra-relativistic electrons in the Van Allen radiation belts JF - Nature Communications Y1 - 2016 U6 - https://doi.org/10.1038/ncomms12883 SN - 2041-1723 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Kim, Kyung-Chan A1 - Shprits, Yuri Y. A1 - Blake, J. Bernard T1 - Fast injection of the relativistic electrons into the inner zone and the formation of the split-zone structure during the Bastille Day storm in July 2000 JF - Journal of geophysical research : Space physics N2 - During the July 2000 geomagnetic storm, known as the Bastille Day storm, Solar, Anomalous, and Magnetospheric Particle Explorer (SAMPEX)/Heavy Ion Large Telescope (HILT) observed a strong injection of similar to 1MeV electrons into the slot region (L similar to 2.5) during the storm main phase. Then, during the following month, electrons were clearly seen diffusing inward down to L=2 and forming a pronounced split structure encompassing a narrow, newly formed slot region around L=3. SAMPEX observations are first compared with electron and proton observations on HEO-3 and NOAA-15 to validate that the observed unusual dynamics was not caused by proton contamination of the SAMPEX instrument. The time-dependent 3-D Versatile Electron Radiation Belt (VERB) simulation of 1MeV electron flux evolution is compared with the SAMPEX/HILT observations. The results show that the VERB code predicts overall time evolution of the observed split structure. The simulated split structure is produced by pitch angle scattering into the Earth atmosphere of similar to 1MeV electrons by plasmaspheric hiss. KW - inner radiation zone and slot region KW - Bastille Day geomagnetic storm KW - 3-D diffusion simulation KW - plasmaspheric hiss Y1 - 2016 U6 - https://doi.org/10.1002/2015JA022072 SN - 2169-9380 SN - 2169-9402 VL - 121 SP - 8329 EP - 8342 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Di Capua, Giorgia A1 - Coumou, Dim T1 - Changes in meandering of the Northern Hemisphere circulation JF - Environmental research letters N2 - Strong waves in the mid-latitude circulation have been linked to extreme surface weather and thus changes in waviness could have serious consequences for society. Several theories have been proposed which could alter waviness, including tropical sea surface temperature anomalies or rapid climate change in the Arctic. However, so far it remains unclear whether any changes in waviness have actually occurred. Here we propose a novel meandering index which captures the maximum waviness in geopotential height contours at any given day, using all information of the full spatial position of each contour. Data are analysed on different time scale (from daily to 11 day running means) and both on hemispheric and regional scales. Using quantile regressions, we analyse how seasonal distributions of this index have changed over 1979-2015. The most robust changes are detected for autumn which has seen a pronounced increase in strongly meandering patterns at the hemispheric level as well as over the Eurasian sector. In summer for both the hemisphere and the Eurasian sector, significant downward trends in meandering are detected on daily timescales which is consistent with the recently reported decrease in summer storm track activity. The American sector shows the strongest increase in meandering in the warm season: in particular for 11 day running mean data, indicating enhanced amplitudes of quasi-stationary waves. Our findings have implications for both the occurrence of recent cold spells and persistent heat waves in the mid-latitudes. KW - Rossby waves KW - climate change KW - extreme events KW - mid-latitudes flow Y1 - 2016 U6 - https://doi.org/10.1088/1748-9326/11/9/094028 SN - 1748-9326 VL - 11 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Noury, M. A1 - Bernet, M. A1 - Schildgen, Taylor F. A1 - Simon-Labric, T. A1 - Philippon, M. A1 - Sempere, T. T1 - Crustal-scale block tilting during Andean trench-parallel extension: Structural and geo-thermochronological insights JF - Tectonics N2 - Despite a long history of plate convergence at the western margin of the South American plate that has been ongoing since at least the Early Paleozoic, the southern Peruvian fore-arc displays little to no evidence of shortening. In the light of this observation, we assess the deformation history of the southern Peruvian fore-arc and its geodynamic implications. To accomplish this, we present a new structural and geo-thermochronological data set (zircon U-Pb, mica Ar-40/Ar-39, apatite and zircon fission-track and zircon (U-Th)/He analyses) for samples collected along a 400km long transect parallel to the trench. Our results show that the Mesoproterozoic gneissic basement was mainly at temperatures 350 degrees C since the Neoproterozoic and was later intruded by Jurassic volcanic arc plutons. Along the coast, a peculiar apatite fission-track age pattern, coupled with field observations and a synthesis of available geological maps, allows us to identify crustal-scale tilted blocks that span the coastal Peruvian fore-arc. These blocks, bounded by normal faults that are orthogonal to the trench, suggest post-60Ma trench-parallel extension that potentially accommodated oroclinal bending in this region. Block tilting is consistent with the observed and previously described switch in the location of sedimentary sources in the fore-arc basin. Our data set allows us to estimate the cumulative slip on these faults to be less than 2km and questions the large amount of trench-parallel extension suggested to have accommodated this bending. KW - Central Andes KW - Peruvian fore arc KW - thermochronology KW - trench-parallel extension KW - oroclinal bending Y1 - 2016 U6 - https://doi.org/10.1002/2016TC004231 SN - 0278-7407 SN - 1944-9194 VL - 35 SP - 2052 EP - 2069 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Koshkina, Olga A1 - Westmeier, Dana A1 - Lang, Thomas A1 - Bantz, Christoph A1 - Hahlbrock, Angelina A1 - Würth, Christian A1 - Resch-Genger, Ute A1 - Braun, Ulrike A1 - Thiermann, Raphael A1 - Weise, Christoph A1 - Eravci, Murat A1 - Mohr, Benjamin A1 - Schlaad, Helmut A1 - Stauber, Roland H. A1 - Docter, Dominic A1 - Bertin, Annabelle A1 - Maskos, Michael T1 - Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake JF - Macromolecular bioscience N2 - Due to the adsorption of biomolecules, the control of the biodistribution of nanoparticles is still one of the major challenges of nanomedicine. Poly(2-ethyl-2-oxazoline) (PEtOx) for surface modification of nanoparticles is applied and both protein adsorption and cellular uptake of PEtOxylated nanoparticles versus nanoparticles coated with poly(ethylene glycol) (PEG) and non-coated positively and negatively charged nanoparticles are compared. Therefore, fluorescent poly(organosiloxane) nanoparticles of 15 nm radius are synthesized, which are used as a scaffold for surface modification in a grafting onto approach. With multi-angle dynamic light scattering, asymmetrical flow field-flow fractionation, gel electrophoresis, and liquid chromatography-mass spectrometry, it is demonstrated that protein adsorption on PEtOxylated nanoparticles is extremely low, similar as on PEGylated nanoparticles. Moreover, quantitative microscopy reveals that PEtOxylation significantly reduces the non-specific cellular uptake, particularly by macrophage-like cells. Collectively, studies demonstrate that PEtOx is a very effective alternative to PEG for stealth modification of the surface of nanoparticles. KW - cellular uptake KW - nanoparticles KW - poly(2-ethyl-2oxazoline) KW - poly(ethylene glycol) KW - protein adsorption Y1 - 2016 U6 - https://doi.org/10.1002/mabi.201600074 SN - 1616-5187 SN - 1616-5195 VL - 16 SP - 1287 EP - 1300 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Zaklan, Aleksandar A1 - Abrell, Jan A1 - Neumann, Anne T1 - Stationarity changes in long-run energy commodity prices JF - Energy economics N2 - Situated at the intersection of the literatures on speculative storage and non-renewable commodity scarcity, this paper considers whether changes in persistence have occurred in long-run U.S. prices of the energy commodities crude oil, natural gas and bituminous coal. We allow for a structural break when testing for a break in persistence to avoid a change in the stochastic properties of prices being confounded by an unaccounted-for deterministic shift in the price series. We find that coal prices are trend stationary throughout their evolution and that oil prices change from stationarity to non-stationarity in the decade between the late 1960s to late 1970s. The result on gas prices is ambiguous. Our results demonstrate the importance of accounting for a possible structural shift when testing for breaks in persistence, while being robust to the exact date of the structural break. Based on our analysis we caution against viewing long-run energy commodity prices as being non-stationary and conclude in favor of modeling commodity market fundamentals as stationary, meaning that speculative storage will tend to have a dampening effect on prices. We also cannot reject that long-run prices of coal and, with some hesitation, gas follow a Hotelling-type rule. In contrast, we reject the Hotelling rule for oil prices since the late 1960s/early 1970s. (C) 2016 Elsevier B.V. All rights reserved. KW - Non-renewable commodity prices KW - Competitive storage KW - Resource scarcity KW - Stationarity KW - Structural breaks Y1 - 2016 U6 - https://doi.org/10.1016/j.eneco.2016.07.022 SN - 0140-9883 SN - 1873-6181 VL - 59 SP - 96 EP - 103 PB - Elsevier CY - Amsterdam ER -