TY - GEN A1 - Hanack, Katja A1 - Schloer, Anja A1 - Holzloehner, Pamela A1 - Listek, Martin A1 - Bauer, Cindy A1 - Butze, Monique A1 - Micheel, Burkhard A1 - Hentschel, Christian A1 - Sowa, Mandy A1 - Roggenbuck, Dirk A1 - Schierack, Peter A1 - Fuener, Jonas A1 - Schliebs, Erik A1 - Goihl, Alexander A1 - Reinhold, Dirk T1 - Camelid nanobodies specific to human pancreatic glycoprotein 2 T2 - The journal of immunology N2 - Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified to be a major autoantigenic target in Crohn’s disease patients. It was discussed recently that a long and a short isoform of GP2 exists whereas the short isoform is often detected by GP2-specific autoantibodies. In the outcome of inflammatory bowel diseases, these GP2-specific autoantibodies are discussed as new serological markers for diagnosis and therapeutic monitoring. To investigate this further, camelid nanobodies were generated by phage display and selected against the short isoform of GP2 in order to isolate specific tools for the discrimination of both isoforms. Nanobodies are single domain antibodies derived from camelid heavy chain only antibodies and characterized by a high stability and solubility. The selected candidates were expressed, purified and validated regarding their binding properties in different enzyme-linked immunosorbent assays formats, immunofluorescence, immunohistochemistry and surface plasmon resonance spectroscopy. Four different nanobodies could be selected whereof three recognize the short isoform of GP2 very specifically and one nanobody showed a high binding capacity for both isoforms. The KD values measured for all nanobodies were between 1.3 nM and 2.3 pM indicating highly specific binders suitable for the application as diagnostic tool in inflammatory bowel disease. Y1 - 2016 SN - 0022-1767 SN - 1550-6606 VL - 196 SP - 313 EP - 328 PB - American Assoc. of Immunologists CY - Bethesda ER - TY - GEN A1 - Grüne, Stefanie T1 - Allais on Intuitions and the Objective Reality of the Categories T2 - European journal of philosophy Y1 - 2016 U6 - https://doi.org/10.1111/ejop.12139 SN - 0966-8373 SN - 1468-0378 VL - 24 SP - 241 EP - 252 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Foerster, Verena A1 - Vogelsang, Ralf A1 - Junginger, Annett A1 - Asrat, Asfawossen A1 - Lamb, Henry F. A1 - Schäbitz, Frank A1 - Trauth, Martin H. T1 - Reply to the comment on "Environmental change and human occupation of southern Ethiopia and northern Kenya during the last 20,000 years. Quaternary Science Reviews 129: 333-340" T2 - Quaternary science reviews : the international multidisciplinary research and review journal Y1 - 2016 U6 - https://doi.org/10.1016/j.quascirev.2016.04.003 SN - 0277-3791 VL - 141 SP - 130 EP - 133 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Esguerra, Alejandro A1 - Helmerich, Nicole A1 - Risse, Thomas T1 - Introduction T2 - Sustainability Politics and Limited Statehood: Contesting the New Modes of Governance N2 - The Paris Agreement for Climate Change or the Sustainable Development Goals (SDGs) rely on new modes of governance for implementation. Indeed, new modes of governance such as market-based instruments, public-private partnerships or multi-stakeholder initiatives have been praised for playing a pivotal role in effective and legitimate sustainability governance. Yet, do they also deliver in areas of limited statehood? States such as Malaysia or the Dominican Republic partly lack the ability to implement and enforce rules; their statehood is limited. This introduction provides the analytical framework of this volume and critically examines the performance of new modes of governance in areas of limited statehood, drawing on the book’s in-depth case studies on issues of climate change, biodiversity, and health. Y1 - 2016 SN - 978-3-319-39871-6 SN - 978-3-319-39870-9 U6 - https://doi.org/10.1007/978-3-319-39871-6_1 SP - 1 EP - 22 PB - Palgrave Macmillan, Cham CY - Basingstoke ER - TY - GEN A1 - Esguerra, Alejandro ED - Esguerra, Alejandro ED - Helmerich, Nicole ED - Risse, Thomas T1 - Conclusion T2 - Sustainability Politics and Limited Statehood: Contesting the New Modes of Governance N2 - This chapter revisits the role of the new modes of governance in areas of limited statehood. First, it states that there is no linear relationship between degrees of statehood and the overall effectiveness of new modes of sustainability governance. Second, the chapter states that, in most of the cases, national governments are hesitant or even actively hamper the development of new modes of governance. Third, it shows that the absence of the shadow of hierarchy can indeed lead to ineffective new modes of governance. However, the shadow of hierarchy does not necessarily need to be cast by states. Finally, the author reviews the complexities involved in participatory practices, stressing the importance of institutional structures and knowledgeable brokers. The chapter concludes by outlining fields for future research. Y1 - 2016 SN - 978-3-319-39871-6 SN - 978-3-319-39870-9 U6 - https://doi.org/10.1007/978-3-319-39871-6_9 SP - 211 EP - 224 PB - Cham CY - Basingstoke ER - TY - GEN A1 - Esguerra, Alejandro T1 - "A Comment That Might Help Us to Move Along" BT - Brokers in Negotiation Systems T2 - Sustainability Politics and Limited Statehood : Contesting the New Modes of Governance N2 - This chapter investigates the trajectory of establishing the Forest Stewardship Council (FSC) in the early 1990s as the first private transnational certification organization with an antagonistic stakeholder body. Its main contribution is a micro-analysis of the founding assembly in 1993. By investigating the role of brokers within the negotiation as one institutional scope condition for ‘arguing’ having occurred, the chapter adopts a dramaturgical approach. It contends that the authority of brokers is not necessarily institutionally given, but needs to be gained: brokers have to prove situationally that their knowledge is relevant and that they are speaking impartially in the interest of progress rather than their own. The chapter stresses the importance of procedural knowledge which brokers provide in contrast to policy knowledge. Y1 - 2016 SN - 978-3-319-39871-6 SN - 978-3-319-39870-9 U6 - https://doi.org/10.1007/978-3-319-39871-6_2 SP - 25 EP - 46 PB - Cham CY - Basingstoke ER - TY - GEN A1 - Ehmer, Oliver A1 - Barth-Weingarten, Dagmar T1 - Adverbial patterns in interaction T2 - Language sciences Y1 - 2016 U6 - https://doi.org/10.1016/j.langsci.2016.05.001 SN - 0388-0001 SN - 1873-5746 VL - 58 SP - 1 EP - 7 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Doege, N. A1 - Hoenzke, S. A1 - Schumacher, Fabian A1 - Balzus, Benjamin A1 - Colombo, Miriam A1 - Hadam, S. A1 - Rancan, F. A1 - Blume-Peytavi, Ulrike A1 - Schindler, A. A1 - Ruehl, E. A1 - Skov, P. A1 - Church, Martin K. A1 - Hedtrich, Sarah A1 - Kleuser, Burkhard A1 - Bodmeier, Roland A1 - Vogt, A. T1 - Ex vivo microdialysis used for the preclinical assessment of anti-inflammatory therapy T2 - Experimental dermatology : the official journal of the European Immunodermatology Society Y1 - 2016 SN - 0906-6705 SN - 1600-0625 VL - 25 SP - E32 EP - E32 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Demmerling, Christoph A1 - Krüger, Hans-Peter A1 - Habermas, Jürgen T1 - Communicative Reason Juergen Habermas, interviewed by Christoph Demmerling and Hans-Peter Krueger T2 - Deutsche Zeitschrift für Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung N2 - Jurgen Habermas explicates the concept of communicative reason. He explains the key assumptions of the philosophy of language and social theory associated with this concept. Also discussed is the category of life-world and the role of the body-mind difference for the consciousness of exclusivity in our access to subjective experience. as well as the role of emotions and perceptions in the context of a theory of communicative action. The question of the redemption of the various validity claims as they are associated with the performance of speech acts is related to processes of social learning and to the role of negative experiences. Finally the interview deals with the relationship between religion and reason and the importance of religion in modern, post-secular societies. Questions about the philosophical culture of our present times are discussed at the end of the conversation. KW - Jurgen Habermas KW - communicative action KW - communicative reason KW - critical theory KW - life-world KW - religion KW - post-secular society Y1 - 2016 U6 - https://doi.org/10.1515/dzph-2016-0061 SN - 0012-1045 SN - 2192-1482 VL - 64 SP - 806 EP - 827 PB - De Gruyter CY - Berlin ER - TY - GEN A1 - Davos, C. H. A1 - Doherty, P. A1 - Voller, Heinz A1 - Salzwedel, Annett A1 - Saure, D. A1 - Metzendorf, M. I. A1 - Jensen, K. A1 - Schmid, J. P. A1 - Rauch, B. T1 - The prognostic effect of cardiac rehabilitation in the era of acute revascularization and statin therapy: the cardiac rehabilitation outcome study (CROS) T2 - European heart journal Y1 - 2016 SN - 0195-668X SN - 1522-9645 VL - 37 SP - 645 EP - 645 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Cajar, Anke A1 - Engbert, Ralf A1 - Laubrock, Jochen T1 - Eye movements during gaze-contingent spatial-frequency filtering of real-world scenes: Effects of filter location, cutoff, and size T2 - Perception Y1 - 2016 SN - 0301-0066 SN - 1468-4233 VL - 45 SP - 126 EP - 126 PB - Sage Publ. CY - London ER - TY - GEN A1 - Bürger, Andreas A1 - Magdans, Uta A1 - Gies, Hermann T1 - Adsorption of amino acids on the magnetite-(111)-surface: a force field study (vol 19, 851, 2013) T2 - Journal of molecular modeling Y1 - 2016 U6 - https://doi.org/10.1007/s00894-016-3124-8 SN - 1610-2940 SN - 0948-5023 VL - 22 PB - Springer CY - New York ER - TY - GEN A1 - Bubeck, Philip A1 - Aerts, Jeroen C. J. H. A1 - de Moel, Hans A1 - Kreibich, Heidi T1 - Preface: Flood-risk analysis and integrated management T2 - Natural hazards and earth system sciences Y1 - 2016 U6 - https://doi.org/10.5194/nhess-16-1005-2016 SN - 1561-8633 VL - 16 SP - 1005 EP - 1010 PB - Copernicus CY - Göttingen ER - TY - GEN A1 - Bijleveld, Catrien A1 - Zoutewelle-Terovan, Mioara A1 - Huschek, Doreen A1 - Liefbroer, Aart C. T1 - Criminal careers and demographic outcomes: An introduction to the special issue T2 - Advances in life course research Y1 - 2016 U6 - https://doi.org/10.1016/j.alcr.2016.05.001 SN - 1569-4909 SN - 1879-6974 VL - 28 SP - 1 EP - 5 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Beurskens, Rainer A1 - Mühlbauer, Thomas A1 - Cardinale, M. A1 - Granacher, Urs T1 - Effects of Strength and Balance Training on the Leg Power Performance of old People T2 - Zeitschrift für Gerontologie und Geriatrie Y1 - 2016 SN - 0948-6704 SN - 1435-1269 VL - 49 SP - S113 EP - S113 PB - Springer CY - Heidelberg ER - TY - GEN A1 - Berenstein, Igal A1 - Beta, Carsten A1 - De Decker, Yannick T1 - Comment on "Flow-induced arrest of spatiotemporal chaos and transition to a stationary pattern in the Gray-Scott model" T2 - Physical review : E, Statistical, nonlinear and soft matter physics N2 - In this Comment, we review the results of pattern formation in a reaction-diffusion-advection system following the kinetics of the Gray-Scott model. A recent paper by Das [Phys. Rev. E 92, 052914 (2015)] shows that spatiotemporal chaos of the intermittency type can disappear as the advective flow is increased. This study, however, refers to a single point in the space of kinetic parameters of the original Gray-Scott model. Here we show that the wealth of patterns increases substantially as some of these parameters are changed. In addition to spatiotemporal intermittency, defect-mediated turbulence can also be found. In all cases, however, the chaotic behavior is seen to disappear as the advective flow is increased, following a scenario similar to what was reported in our earlier work [I. Berenstein and C. Beta, Phys. Rev. E 86, 056205 (2012)] as well as by Das. We also point out that a similar phenomenon can be found in other reaction-diffusion-advection models, such as the Oregonator model for the Belousov-Zhabotinsky reaction under flow conditions. Y1 - 2016 U6 - https://doi.org/10.1103/PhysRevE.94.046201 SN - 2470-0045 SN - 2470-0053 VL - 94 PB - American Physical Society CY - College Park ER - TY - GEN A1 - Behm, David George A1 - Mühlbauer, Thomas A1 - Kibele, Armin A1 - Granacher, Urs T1 - Effects of Strength Training Using Unstable Surfaces on Strength, Power and Balance Performance Across the Lifespan: A Systematic Review and Meta-analysis (vol 45, pg 1645, 2015) T2 - Sports medicine Y1 - 2016 U6 - https://doi.org/10.1007/s40279-016-0497-x SN - 0112-1642 SN - 1179-2035 VL - 46 SP - 451 EP - 451 PB - Springer CY - Northcote ER - TY - GEN A1 - Battiston, Stefano A1 - Farmer, J. Doyne A1 - Flache, Andreas A1 - Garlaschelli, Diego A1 - Haldane, Andrew G. A1 - Heesterbeek, Hans A1 - Hommes, Cars A1 - Jaeger, Carlo A1 - May, Robert A1 - Scheffer, Marten T1 - COMPLEX SYSTEMS Complexity theory and financial regulation T2 - Science N2 - Traditional economic theory could not explain, much less predict, the near collapse of the financial system and its long-lasting effects on the global economy. Since the 2008 crisis, there has been increasing interest in using ideas from complexity theory to make sense of economic and financial markets. Concepts, such as tipping points, networks, contagion, feedback, and resilience have entered the financial and regulatory lexicon, but actual use of complexity models and results remains at an early stage. Recent insights and techniques offer potential for better monitoring and management of highly interconnected economic and financial systems and, thus, may help anticipate and manage future crises. Y1 - 2016 U6 - https://doi.org/10.1126/science.aad0299 SN - 0036-8075 SN - 1095-9203 VL - 351 SP - 818 EP - 819 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - GEN A1 - Battiston, Stefano A1 - Farmer, Doyne A1 - Flache, Andreas A1 - Garlaschelli, Diego A1 - Haldane, Andy A1 - Heesterbeek, Hans A1 - Hommes, Cars A1 - Jaeger, Carlo A1 - May, Robert A1 - Scheffer, Marten T1 - Financial complexity: Accounting for fraud Response T2 - Science Y1 - 2016 U6 - https://doi.org/10.1126/science.352.6283.302 SN - 0036-8075 SN - 1095-9203 VL - 352 SP - 302 EP - 302 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - GEN A1 - Barniske, Andreas A1 - Oskinova, Lidia M. A1 - Hamann, Wolf-Rainer T1 - Two extremely luminous WN stars in the Galactic center with circumstellar emission from dust and gas (vol 486, pg 971, 2008) T2 - Physical chemistry, chemical physics : a journal of European Chemical Societies KW - stars: Wolf-Rayet KW - HII regions KW - Galaxy: center KW - stars: individual: WR 102ka KW - stars: individual: WR 102c KW - errata, addenda Y1 - 2016 U6 - https://doi.org/10.1051/0004-6361/200809568e SN - 1432-0746 VL - 587 PB - EDP Sciences CY - Les Ulis ER -