TY  - JOUR
A1  - Haegele, Claudia
A1  - Schlagenhauf, Florian
A1  - Rapp, Michael Armin
A1  - Sterzer, Philipp
A1  - Beck, Anne
A1  - Bermpohl, Felix
A1  - Stoy, Meline
A1  - Stroehle, Andreas
A1  - Wittchen, Hans-Ulrich
A1  - Dolan, Raymond J.
A1  - Heinz, Andreas
T1  - Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders
JF  - Psychopharmacology
N2  - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
 We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
 During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
 Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
KW  - Dimensional
KW  - fMRI
KW  - Reward system
KW  - Ventral striatum
KW  - Monetary incentive delay task
KW  - Depressive symptoms
Y1  - 2015
U6  - https://doi.org/10.1007/s00213-014-3662-7
SN  - 0033-3158
SN  - 1432-2072
VL  - 232
IS  - 2
SP  - 331
EP  - 341
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Bondü, Rebecca
A1  - Esser, Günter
T1  - Justice and rejection sensitivity in children and adolescents with ADHD symptoms
JF  - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry
N2  - Justice sensitivity captures individual differences in the frequency with which injustice is perceived and the intensity of emotional, cognitive, and behavioral reactions to it. Persons with ADHD have been reported to show high justice sensitivity, and a recent study provided evidence for this notion in an adult sample. In 1,235 German 10- to 19-year olds, we measured ADHD symptoms, justice sensitivity from the victim, observer, and perpetrator perspective, the frequency of perceptions of injustice, anxious and angry rejection sensitivity, depressive symptoms, conduct problems, and self-esteem. Participants with ADHD symptoms reported significantly higher victim justice sensitivity, more perceptions of injustice, and higher anxious and angry rejection sensitivity, but significantly lower perpetrator justice sensitivity than controls. In latent path analyses, justice sensitivity as well as rejection sensitivity partially mediated the link between ADHD symptoms and comorbid problems when considered simultaneously. Thus, both justice sensitivity and rejection sensitivity may contribute to explaining the emergence and maintenance of problems typically associated with ADHD symptoms, and should therefore be considered in ADHD therapy.
KW  - ADHD
KW  - Justice sensitivity
KW  - Rejection sensitivity
KW  - Conduct problems
KW  - Depressive symptoms
Y1  - 2015
U6  - https://doi.org/10.1007/s00787-014-0560-9
SN  - 1018-8827
SN  - 1435-165X
VL  - 24
IS  - 2
SP  - 185
EP  - 198
PB  - Springer
CY  - New York
ER  -