TY  - JOUR
A1  - Şener, Ulaş
T1  - Rodrik, Dani (2015): Economics Rules: The Rights and Wrongs of the Dismal Science / rezensiert von Ulaş Şener
JF  - European journal of economics and economic policies : intervention ; EJEEP
Y1  - 2017
U6  - https://doi.org/10.4337/ejeep.2017.03.08
SN  - 2052-7764
SN  - 2195-3376
VL  - 14
SP  - 375
EP  - 377
PB  - Elgar
CY  - Cheltenham
ER  - 
TY  - JOUR
A1  - Yarman, Aysu
A1  - Jetzschmann, Katharina J.
A1  - Neumann, Bettina
A1  - Zhang, Xiaorong
A1  - Wollenberger, Ulla
A1  - Cordin, Aude
A1  - Haupt, Karsten
A1  - Scheller, Frieder W.
T1  - Enzymes as Tools in MIP-Sensors
JF  - Chemosensors
N2  - Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as tracers for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences.
KW  - enzymatic MIP synthesis
KW  - template digestion
KW  - enzyme tracer
KW  - enzymatic analyte conversion
KW  - molecularly imprinted polymers
Y1  - 2017
U6  - https://doi.org/10.3390/chemosensors5020011
SN  - 2227-9040
VL  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Yang, Xiaoping
A1  - Darko, Kwame Oteng
A1  - Huang, Yanjun
A1  - He, Caimei
A1  - Yang, Huansheng
A1  - He, Shanping
A1  - Li, Jianzhong
A1  - Li, Jian
A1  - Hocher, Berthold
A1  - Yin, Yulong
T1  - Resistant starch regulates gut microbiota
BT  - structure, biochemistry and cell signalling
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.
KW  - Resistant starch
KW  - Gut microbiota
KW  - Nutrition
Y1  - 2017
U6  - https://doi.org/10.1159/000477386
SN  - 1015-8987
SN  - 1421-9778
VL  - 42
IS  - 1
SP  - 306
EP  - 318
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Wiesner-Reinhold, Melanie
A1  - Schreiner, Monika
A1  - Baldermann, Susanne
A1  - Schwarz, Dietmar
A1  - Hanschen, Franziska S.
A1  - Kipp, Anna Patricia
A1  - Rowan, Daryl D.
A1  - Bentley-Hewitt, Kerry L.
A1  - McKenzie, Marian J.
T1  - Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health
JF  - Frontiers in plant science
N2  - Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds of millions of people worldwide, particularly in developing countries, and there is increasing awareness that suboptimal supply of Se can also negatively affect human health. Selenium enters the diet primarily through the ingestion of plant and animal products. Although, plants are not dependent on Se they take it up from the soil through the sulphur (S) uptake and assimilation pathways. Therefore, geographic differences in the availability of soil Se and agricultural practices have a profound influence on the Se content of many foods, and there are increasing efforts to biofortify crop plants with Se. Plants from the Brassicales are of particular interest as they accumulate and synthesize Se into forms with additional health benefits, such as methylselenocysteine (MeSeCys). The Brassicaceae are also well-known to produce the glucosinolates; S-containing compounds with demonstrated human health value. Furthermore, the recent discovery of the selenoglucosinolates in the Brassicaceae raises questions regarding their potential bioefficacy. In this review we focus on Se uptake and metabolism in the Brassicaceae in the context of human health, particularly cancer prevention and immunity. We investigate the close relationship between Se and S metabolism in this plant family, with particular emphasis on the selenoglucosinolates, and consider the methodologies available for identifying and quantifying further novel Se-containing compounds in plants. Finally, we summarize the research of multiple groups investigating biofortification of the Brassicaceae and discuss which approaches might be most successful for supplying Se deficient populations in the future.
KW  - Brassica vegetables
KW  - selenium
KW  - biofortification
KW  - glucosinolates
KW  - human health
KW  - immune system
KW  - cancer
KW  - analytical methods
Y1  - 2017
U6  - https://doi.org/10.3389/fpls.2017.01365
SN  - 1664-462X
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wick, Kristin
A1  - Leeger-Aschmann, Claudia S.
A1  - Monn, Nico D.
A1  - Radtke, Thomas
A1  - Ott, Laura V.
A1  - Rebholz, Cornelia E.
A1  - Cruz, Sergio
A1  - Gerber, Natalie
A1  - Schmutz, Einat A.
A1  - Puder, Jardena J.
A1  - Munsch, Simone
A1  - Kakebeeke, Tanja H.
A1  - Jenni, Oskar G.
A1  - Granacher, Urs
A1  - Kriemler, Susi
T1  - Interventions to Promote Fundamental Movement Skills in Childcare and Kindergarten: A Systematic Review and Meta-Analysis
JF  - Sports medicine
N2  - Background Proficiency in fundamental movement skills (FMS) lays the foundation for being physically active and developing more complex motor skills. Improving these motor skills may provide enhanced opportunities for the development of a variety of perceptual, social, and cognitive skills. Objective The objective of this systematic review and meta-analysis was to assess the effects of FMS interventions on actual FMS, targeting typically developing young children. Method Searches in seven databases (CINAHL, Embase, MEDLINE, PsycINFO, PubMed, Scopus, Web of Science) up to August 2015 were completed. Trials with children (aged 2-6 years) in childcare or kindergarten settings that applied FMS-enhancing intervention programs of at least 4 weeks and meeting the inclusion criteria were included. Standardized data extraction forms were used. Risk of bias was assessed using a standard scoring scheme (Effective Public Health Practice Project-Quality Assessment Tool for Quantitative Studies [EPHPP]). We calculated effects on overall FMS, object control and locomotor subscales (OCS and LMS) by weighted standardized mean differences (SMDbetween) using random-effects models. Certainty in training effects was evaluated using GRADE (Grading of Recommendations Assessment, Development, and Evaluation System). Results Thirty trials (15 randomized controlled trials and 15 controlled trials) involving 6126 preschoolers (aged 3.3-5.5 years) revealed significant differences among groups in favor of the intervention group (INT) with small-to-large effects on overall FMS (SMDbetween 0.46), OCS (SMDbetween 1.36), and LMS (SMDbetween 0.94). Our certainty in the treatment estimates based on GRADE is very low. Conclusions Although there is relevant effectiveness of programs to improve FMS proficiency in healthy young children, they need to be interpreted with care as they are based on low-quality evidence and immediate post-intervention effects without long-term follow-up.
Y1  - 2017
U6  - https://doi.org/10.1007/s40279-017-0723-1
SN  - 0112-1642
SN  - 1179-2035
VL  - 47
SP  - 2045
EP  - 2068
PB  - Springer
CY  - Northcote
ER  - 
TY  - JOUR
A1  - Weiß, Norman
T1  - Claudio Franzius/Franz C. Mayer/Jürgen Meyer (Hrsg.), Modelle des Parlamentarismus im 21. Jahrhundert. Neue Ordnungen von Recht und Politik / [rezensiert von] Norman Weiß
JF  - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-405455
SN  - 1434-2820
VL  - 22
IS  - 1
SP  - 80
EP  - 81
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - van der Lubbe, H. J. L.
A1  - Krause-Nehring, J.
A1  - Junginger, A.
A1  - Garcin, Yannick
A1  - Joordens, J. C. A.
A1  - Davies, G. R.
A1  - Beck, C.
A1  - Feibel, C. S.
A1  - Johnson, T. C.
A1  - Vonhof, H. B.
T1  - Gradual or abrupt? Changes in water source of Lake Turkana (Kenya) during the African Humid Period inferred from Sr isotope ratios
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
Y1  - 2017
U6  - https://doi.org/10.1016/j.quascirev.2017.08.010
SN  - 0277-3791
VL  - 174
SP  - 1
EP  - 12
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Temmen, Jens
T1  - The Unsettlement of America: Translation, Interpretation, and the Story of Don Luis de Velasco, 1560-1945
JF  - Zeitschrift für Anglistik und Amerikanistik : a quarterly of language, literature and cultur
Y1  - 2017
U6  - https://doi.org/10.1515/zaa-2017-0011
SN  - 0044-2305
SN  - 2196-4726
VL  - 65
IS  - 1
SP  - 117
EP  - 119
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Subetto, D. A.
A1  - Nazarova, Larisa B.
A1  - Pestryakova, Luidmila Agafyevna
A1  - Syrykh, Liudmila
A1  - Andronikov, A. V.
A1  - Biskaborn, B.
A1  - Diekmann, Bernhard
A1  - Kuznetsov, D. D.
A1  - Sapelko, T. V.
A1  - Grekov, I. M.
T1  - Paleolimnological studies in Russian northern Eurasia
BT  - a review
JF  - Contemporary Problems of Ecology
N2  - This article presents a review of the current data on the level of paleolimnological knowledge about lakes in the Russian part of the northern Eurasia. The results of investigation of the northwestern European part of Russia as the best paleolimnologically studied sector of the Russian north is presented in detail. The conditions of lacustrine sedimentation at the boundary between the Late Pleistocene and Holocene and the role of different external factors in formation of their chemical composition, including active volcanic activity and possible large meteorite impacts, are also discussed. The results of major paleoclimatic and paleoecological reconstructions in northern Siberia are presented. Particular attention is given to the databases of abiotic and biotic parameters of lake ecosystems as an important basis for quantitative reconstructions of climatic and ecological changes in the Late Pleistocene and Holocene. Keywords: paleolimnology, lakes, bottom sediments, northern.
KW  - paleolimnology
KW  - lakes
KW  - bottom sediments
KW  - northern Eurasia
KW  - Russian Arctic
KW  - databases
Y1  - 2017
U6  - https://doi.org/10.1134/S1995425517040102
SN  - 1995-4255
SN  - 1995-4263
VL  - 10
SP  - 327
EP  - 335
PB  - Pleiades Publ.
CY  - New York
ER  - 
TY  - JOUR
A1  - Spahn, Hannah
T1  - Rezension zu: Helo, Ari, Thomas Jefferson's ethics and the politics of human progress: the morality of a slaveholder. - New York, NY: Cambridge Univ. Press, 2014. - ISBN 978-1-107-04078-6
JF  - Journal of the Early Republic
KW  - Thomas Jefferson
KW  - Ethics
KW  - Progress
KW  - Racism
KW  - Slavery
Y1  - 2017
U6  - https://doi.org/10.1353/jer.2017.0010
SN  - 0275-1275
SN  - 1553-0620
VL  - 37
IS  - 1
SP  - 170
EP  - 173
PB  - University of Pennsylvania Press
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Shprits, Yuri Y.
A1  - Angelopoulos, V.
A1  - Russell, C. T.
A1  - Strangeway, R. J.
A1  - Runov, A.
A1  - Turner, D.
A1  - Caron, R.
A1  - Cruce, P.
A1  - Leneman, D.
A1  - Michaelis, I.
A1  - Petrov, V.
A1  - Panasyuk, M.
A1  - Yashin, I.
A1  - Drozdov, Alexander Y.
A1  - Russell, C. L.
A1  - Kalegaev, V.
A1  - Nazarkov, I.
A1  - Clemmons, J. H.
T1  - Scientific Objectives of Electron Losses and Fields INvestigation Onboard Lomonosov Satellite
JF  - Space science reviews
N2  - The objective of the Electron Losses and Fields INvestigation on board the Lomonosov satellite ( ELFIN-L) project is to determine the energy spectrum of precipitating energetic electrons and ions and, together with other polar-orbiting and equatorial missions, to better understand the mechanisms responsible for scattering these particles into the atmosphere. This mission will provide detailed measurements of the radiation environment at low altitudes. The 400-500 km sun-synchronous orbit of Lomonosov is ideal for observing electrons and ions precipitating into the atmosphere. This mission provides a unique opportunity to test the instruments. Similar suite of instruments will be flown in the future NSF-and NASA-supported spinning CubeSat ELFIN satellites which will augment current measurements by providing detailed information on pitch-angle distributions of precipitating and trapped particles.
KW  - Magnetospheric physics
KW  - Observations
KW  - Particles precipitating
KW  - Particles trapped
KW  - Radiation belts
Y1  - 2017
U6  - https://doi.org/10.1007/s11214-017-0455-4
SN  - 0038-6308
SN  - 1572-9672
VL  - 214
IS  - 1
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Shlapunov, Alexander
A1  - Tarkhanov, Nikolai Nikolaevich
T1  - Golusin-Krylov formulas in complex analysis
JF  - Complex variables and elliptic equations
N2  - This is a brief survey of a constructive technique of analytic continuation related to an explicit integral formula of Golusin and Krylov (1933). It goes far beyond complex analysis and applies to the Cauchy problem for elliptic partial differential equations as well. As started in the classical papers, the technique is elaborated in generalised Hardy spaces also called Hardy-Smirnov spaces.
KW  - Analytic continuation
KW  - inegral formulas
KW  - Cauchy problem
Y1  - 2017
U6  - https://doi.org/10.1080/17476933.2017.1395872
SN  - 1747-6933
SN  - 1747-6941
VL  - 63
IS  - 7-8
SP  - 1142
EP  - 1167
PB  - Routledge
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Serno, Sascha
A1  - Winckler, Gisela
A1  - Anderson, Robert F.
A1  - Jaccard, Samuel L.
A1  - Kienast, Stephanie S.
A1  - Haug, Gerald H.
T1  - Change in dust seasonality as the primary driver for orbital-scale dust storm variability in East Asia
JF  - Geophysical research letters
N2  - Glacial periods are recognized to be dustier than interglacials, but the conditions leading to greater dust mobilization are poorly defined. Here we present a new high-resolution dust record based on Th-230-normalized He-4 flux from Ocean Drilling Program site 882 in the Subarctic North Pacific covering the last 170,000years. By analogy with modern relationships, we infer the mechanisms controlling orbital-scale dust storm variability in East Asia. We propose that orbital-scale dust flux variability is the result of an expansion of the dust season into summer, in addition to more intense dust storms during spring and fall. The primary drivers influencing dust flux include summer insolation at subarctic latitudes and variable Siberian alpine glaciation, which together control the cold air reservoir in Siberia. Changes in the extent of the Northern Hemisphere ice sheets may be a secondary control.
Y1  - 2017
U6  - https://doi.org/10.1002/2016GL072345
SN  - 0094-8276
SN  - 1944-8007
VL  - 44
SP  - 3796
EP  - 3805
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Schöne, Anne-Christin
A1  - Roch, Toralf
A1  - Schulz, Burkhard
A1  - Lendlein, Andreas
T1  - Evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer techniques
JF  - Interface : journal of the Royal Society
N2  - Polymeric biomaterials are of specific relevance in medical and pharmaceutical applications due to their wide range of tailorable properties and functionalities. The knowledge about interactions of biomaterials with their biological environment is of crucial importance for developing highly sophisticated medical devices. To achieve optimal in vivo performance, a description at the molecular level is required to gain better understanding about the surface of synthetic materials for tailoring their properties. This is still challenging and requires the comprehensive characterization of morphological structures, polymer chain arrangements and degradation behaviour. The review discusses selected aspects for evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer methods as powerful techniques for studying interfacial properties, such as morphological and degradation processes. The combination of spectroscopic, microscopic and scattering methods with the Langmuir techniques adapted to polymers can substantially improve the understanding of their in vivo behaviour.
KW  - Langmuir monolayer
KW  - biodegradable polymers
KW  - air - water interface
KW  - protein Langmuir layers
Y1  - 2017
U6  - https://doi.org/10.1098/rsif.2016.1028
SN  - 1742-5689
SN  - 1742-5662
VL  - 14
PB  - Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Schuster, Isabell
A1  - Krahé, Barbara
T1  - The prevalence of sexual aggression in Turkey: A systematic review
JF  - Aggression and violent behavior : a review journa
N2  - Although sexual aggression is recognized as a serious problem worldwide, evidence on the prevalence and impact of sexual aggression is based predominantly on studies from Western countries with a Christian or non-religious majority. Little evidence is available from non-Western countries, especially from Muslim societies. The purpose of the present article was to provide a first systematic review of the studies examining the prevalence of sexual aggression in Turkey, including both victimization and perpetration reports from women and men. Additionally, differences in prevalence rates depending on relationship constellations and characteristics of victims and perpetrators were reviewed. By a two-stage literature search, 56 studies were identified for inclusion. All studies examined sexual victimization of women, only four studies included sexual victimization of men. Data on sexual aggression perpetration were extremely limited, with only two studies providing prevalence rates. Prevalence rates of sexual victimization were found to vary greatly, which may be attributed to a lack of methodological and conceptual consistency across studies. Likewise, no consistent picture was revealed for victims' or perpetrators' sociodemographic or situational characteristics associated with differences in prevalence rates. We discuss reasons for the variability in prevalence rates and outline recommendations for future research.
KW  - Sexual aggression
KW  - Victimization
KW  - Perpetration
KW  - Prevalence
KW  - Turkey
KW  - Review
Y1  - 2017
U6  - https://doi.org/10.1016/j.avb.2017.05.003
SN  - 1359-1789
SN  - 1873-6335
VL  - 37
SP  - 102
EP  - 114
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Schmidt, Martin
A1  - Jochheim, Hubert
A1  - Kersebaum, Kurt-Christian
A1  - Lischeid, Gunnar
A1  - Nendel, Claas
T1  - Gradients of microclimate, carbon and nitrogen in transition zones of fragmented landscapes - a review
JF  - Agricultural and forest meteorology
N2  - Fragmentation of landscapes creates a transition zone in between natural habitats or different kinds of land use. In forested and agricultural landscapes with transition zones, microclimate and matter cycling are markedly altered. This probably accelerates and is intensified by global warming. However, there is no consensus on defining transition zones and quantifying relevant variables for microclimate and matter cycling across disciplines. This article is an attempt to a) revise definitions and offer a framework for quantitative ecologists, b) review the literature on microclimate and matter cycling in transition zones and c) summarise this information using meta-analysis to better understand bio-geochemical and bio-geophysical processes and their spatial extent in transition zones. We expect altered conditions in soils of transition zones to be 10-20 m with a maximum of 50 m, and 25-50 m for above-ground space with a maximum of 125 m.
KW  - Edge effects
KW  - Ecological boundaries
KW  - Matter cycling
KW  - Matter dynamics
KW  - Framework quantitative ecology
KW  - Ecotone hierarchy
Y1  - 2016
U6  - https://doi.org/10.1016/j.agrformet.2016.10.022
SN  - 0168-1923
SN  - 1873-2240
VL  - 232
SP  - 659
EP  - 671
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schinkoeth, Michaela
A1  - Antoniewicz, Franziska
T1  - Automatic Evaluations and Exercising: Systematic Review and Implications for Future Research
JF  - Frontiers in psychology
N2  - The general purpose of this systematic review was to summarize, structure and evaluate the findings on automatic evaluations of exercising. Studies were eligible for inclusion if they reported measuring automatic evaluations of exercising with an implicit measure and assessed some kind of exercise variable. Fourteen nonexperimental and six experimental studies (out of a total N = 1,928) were identified and rated by two independent reviewers. The main study characteristics were extracted and the grade of evidence for each study evaluated. First, results revealed a large heterogeneity in the applied measures to assess automatic evaluations of exercising and the exercise variables. Generally, small to large-sized significant relations between automatic evaluations of exercising and exercise variables were identified in the vast majority of studies. The review offers a systematization of the various examined exercise variables and prompts to differentiate more carefully between actually observed exercise behavior (proximal exercise indicator) and associated physiological or psychological variables (distal exercise indicator). Second, a lack of transparent reported reflections on the differing theoretical basis leading to the use of specific implicit measures was observed. Implicit measures should be applied purposefully, taking into consideration the individual advantages or disadvantages of the measures. Third, 12 studies were rated as providing first-grade evidence (lowest grade of evidence), five represent second-grade and three were rated as third-grade evidence. There is a dramatic lack of experimental studies, which are essential for illustrating the cause-effect relation between automatic evaluations of exercising and exercise and investigating under which conditions automatic evaluations of exercising influence behavior. Conclusions about the necessity of exercise interventions targeted at the alteration of automatic evaluations of exercising should therefore not be drawn too hastily.
KW  - automatic evaluation
KW  - exercise
KW  - associative
KW  - dual-process
KW  - implicitattitude
KW  - affective
Y1  - 2017
U6  - https://doi.org/10.3389/fpsyg.2017.02103
SN  - 1664-1078
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Sadovnichii, V. A.
A1  - Panasyuk, M. I.
A1  - Amelyushkin, A. M.
A1  - Bogomolov, V. V.
A1  - Benghin, V. V.
A1  - Garipov, G. K.
A1  - Kalegaev, V. V.
A1  - Klimov, P. A.
A1  - Khrenov, B. A.
A1  - Petrov, V. L.
A1  - Sharakin, S. A.
A1  - Shirokov, A. V.
A1  - Svertilov, S. I.
A1  - Zotov, M. Y.
A1  - Yashin, I. V.
A1  - Gorbovskoy, E. S.
A1  - Lipunov, V. M.
A1  - Park, I. H.
A1  - Lee, J.
A1  - Jeong, S.
A1  - Kim, M. B.
A1  - Jeong, H. M.
A1  - Shprits, Yuri Y.
A1  - Angelopoulos, V.
A1  - Russell, C. T.
A1  - Runov, A.
A1  - Turner, D.
A1  - Strangeway, R. J.
A1  - Caron, R.
A1  - Biktemerova, S.
A1  - Grinyuk, A.
A1  - Lavrova, M.
A1  - Tkachev, L.
A1  - Tkachenko, A.
A1  - Martinez, O.
A1  - Salazar, H.
A1  - Ponce, E.
T1  - "Lomonosov" Satellite-Space Observatory to Study Extreme Phenomena in Space
JF  - Space science reviews
N2  - The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study: -Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff; -Ultraviolet (UV) transient luminous events in the upper atmosphere; -Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays; -Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances; -Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects; -Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight. This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.
KW  - Gamma-ray bursts
KW  - Ultra-high energy cosmic rays
KW  - Radiation belts
KW  - Space mission
Y1  - 2017
U6  - https://doi.org/10.1007/s11214-017-0425-x
SN  - 0038-6308
SN  - 1572-9672
VL  - 212
SP  - 1705
EP  - 1738
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Romao, Maria Joao
A1  - Coelho, Catarina
A1  - Santos-Silva, Teresa
A1  - Foti, Alessandro
A1  - Terao, Mineko
A1  - Garattini, Enrico
A1  - Leimkühler, Silke
T1  - Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics
JF  - Current Opinion in Chemical Biology
N2  - Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. Mammals are characterized by a complement of species specific AOX isoenzymes, that varies from one in humans (AOX1) to four in rodents (AOX1, AOX2, AOX3 and AOX4). The physiological function of mammalian AOX isoenzymes is unknown, although human AOX1 is an emerging enzyme in phase-I drug metabolism. Indeed, the number of therapeutic molecules under development which act as AOX substrates is increasing. The recent crystallization and structure determination of human AOX1 as well as mouse AOX3 has brought new insights into the mechanisms underlying substrate/inhibitor binding as well as the catalytic activity of this class of enzymes.
Y1  - 2017
U6  - https://doi.org/10.1016/j.cbpa.2017.01.005
SN  - 1367-5931
SN  - 1879-0402
VL  - 37
SP  - 39
EP  - 47
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Norregaard, Kamilla
A1  - Metzler, Ralf
A1  - Ritter, Christine M.
A1  - Berg-Sorensen, Kirstine
A1  - Oddershede, Lene Broeng
T1  - Manipulation and Motion of Organelles and Single Molecules in Living Cells
JF  - Chemical reviews
N2  - The biomolecule is among the most important building blocks of biological systems, and a full understanding of its function forms the scaffold for describing the mechanisms of higher order structures as organelles and cells. Force is a fundamental regulatory mechanism of biomolecular interactions driving many cellular processes. The forces on a molecular scale are exactly in the range that can be manipulated and probed with single molecule force spectroscopy. The natural environment of a biomolecule is inside a living cell, hence, this is the most relevant environment for probing their function. In vivo studies are, however, challenged by the complexity of the cell. In this review, we start with presenting relevant theoretical tools for analyzing single molecule data obtained in intracellular environments followed by a description of state-of-the art visualization techniques. The most commonly used force spectroscopy techniques, namely optical tweezers, magnetic tweezers, and atomic force microscopy, are described in detail, and their strength and limitations related to in vivo experiments are discussed. Finally, recent exciting discoveries within the field of in vivo manipulation and dynamics of single molecule and organelles are reviewed.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.chemrev.6b00638
SN  - 0009-2665
SN  - 1520-6890
VL  - 117
IS  - 5
SP  - 4342
EP  - 4375
PB  - American Chemical Society
CY  - Washington
ER  -