TY - JOUR A1 - Schubert, Mikkel A1 - Jonsson, Hakon A1 - Chang, Dan A1 - Sarkissian, Clio Der A1 - Ermini, Luca A1 - Ginolhac, Aurelien A1 - Albrechtsen, Anders A1 - Dupanloup, Isabelle A1 - Foucal, Adrien A1 - Petersen, Bent Larsen A1 - Fumagalli, Matteo A1 - Raghavan, Maanasa A1 - Seguin-Orlando, Andaine A1 - Korneliussen, Thorfinn S. A1 - Velazquez, Amhed M. V. A1 - Stenderup, Jesper A1 - Hoover, Cindi A. A1 - Rubin, Carl-Johan A1 - Alfarhan, Ahmed H. A1 - Alquraishi, Saleh A. A1 - Al-Rasheid, Khaled A. S. A1 - MacHugh, David E. A1 - Kalbfleisch, Ted A1 - MacLeod, James N. A1 - Rubin, Edward M. A1 - Sicheritz-Ponten, Thomas A1 - Andersson, Leif A1 - Hofreiter, Michael A1 - Marques-Bonet, Tomas A1 - Gilbert, M. Thomas P. A1 - Nielsen, Rasmus A1 - Excoffier, Laurent A1 - Willerslev, Eske A1 - Shapiro, Beth A1 - Orlando, Ludovic T1 - Prehistoric genomes reveal the genetic foundation and cost of horse domestication JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 2014 U6 - https://doi.org/10.1073/pnas.1416991111 SN - 0027-8424 VL - 111 IS - 52 SP - E5661 EP - E5669 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Librado, Pablo A1 - Gamba, Cristina A1 - Gaunitz, Charleen A1 - Sarkissian, Clio Der A1 - Pruvost, Melanie A1 - Albrechtsen, Anders A1 - Fages, Antoine A1 - Khan, Naveed A1 - Schubert, Mikkel A1 - Jagannathan, Vidhya A1 - Serres-Armero, Aitor A1 - Kuderna, Lukas F. K. A1 - Povolotskaya, Inna S. A1 - Seguin-Orlando, Andaine A1 - Lepetz, Sebastien A1 - Neuditschko, Markus A1 - Theves, Catherine A1 - Alquraishi, Saleh A. A1 - Alfarhan, Ahmed H. A1 - Al-Rasheid, Khaled A. S. A1 - Rieder, Stefan A1 - Samashev, Zainolla A1 - Francfort, Henri-Paul A1 - Benecke, Norbert A1 - Hofreiter, Michael A1 - Ludwig, Arne A1 - Keyser, Christine A1 - Marques-Bonet, Tomas A1 - Ludes, Bertrand A1 - Crubezy, Eric A1 - Leeb, Tosso A1 - Willerslev, Eske A1 - Orlando, Ludovic T1 - Ancient genomic changes associated with domestication of the horse JF - Science N2 - The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between similar to 4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs. Y1 - 2017 U6 - https://doi.org/10.1126/science.aam5298 SN - 0036-8075 SN - 1095-9203 VL - 356 SP - 442 EP - 445 PB - American Assoc. for the Advancement of Science CY - Washington ER -