TY  - JOUR
A1  - Abebe, Zeweter
A1  - Haki, Gulelat Desse
A1  - Schweigert, Florian J.
A1  - Henkel, Ina M.
A1  - Baye, Kaleab
T1  - Low breastmilk vitamin A concentration is prevalent in rural Ethiopia
JF  - European journal of clinical nutrition
N2  - Background There is scant information on the breastmilk vitamin A (BMVA) concentration of lactating women in developing countries, partly due to lack of methods applicable in-field. Objective To assess BMVA concentrations of samples collected from lactating women of children aged 6-23 months, in Mecha district, Ethiopia. Subjects/methods Data on socio-demographic and anthropometric characteristics were collected from randomly selected lactating women (n = 104). Breast milk samples were collected and vitamin A concentrations were analyzed using HPLC and iCheck FLUORO then the two measurements were compared. Results The prevalence of underweight (BMI < 18.5 kg/m(2)) among lactating women was 17%. Seventy six percent of the BMVA values were < 1.05 mu mol/l and 81% were < 8 mu g/g fat. The mean BMVA concentration accounted to 41% of the estimated average value for mothers in developing countries. The BMVA values from HPLC and iCheck were correlated (r = 0.59, p = < 0.001), but it was not strong. Conclusions The result indicates the low vitamin A status of the lactating women and their children. It further indicates that intake assessments should not use average BMVA composition. The possibility of using iCheck for monitoring interventions designed to improve vitamin A status of lactating women with low BMVA requires further investigation.
Y1  - 2019
U6  - https://doi.org/10.1038/s41430-018-0334-4
SN  - 0954-3007
SN  - 1476-5640
VL  - 73
IS  - 8
SP  - 1110
EP  - 1116
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Alicke, Marie
A1  - Boakye-Appiah, Justice K.
A1  - Abdul-Jalil, Inusah
A1  - Henze, Andrea
A1  - van der Giet, Markus
A1  - Schulze, Matthias Bernd
A1  - Schweigert, Florian J.
A1  - Mockenhaupt, Frank P.
A1  - Bedu-Addo, George
A1  - Danquah, Ina
T1  - eAdolescent health in rural Ghana: A crosssectional study on the co-occurrence of infectious diseases, malnutrition and cardiometabolic risk factors
JF  - PLoS one
N2  - In sub-Saharan Africa, infectious diseases and malnutrition constitute the main health problems in children, while adolescents and adults are increasingly facing cardio-metabolic conditions. Among adolescents as the largest population group in this region, we investigated the co-occurrence of infectious diseases, malnutrition and cardio-metabolic risk factors (CRFs), and evaluated demographic, socio-economic and medical risk factors for these entities. In a cross-sectional study among 188 adolescents in rural Ghana, malarial infection, common infectious diseases and Body Mass Index were assessed. We measured ferritin, C-reactive protein, retinol, fasting glucose and blood pressure. Socio-demographic data were documented. We analyzed the proportions (95% confidence interval, CI) and the cooccurrence of infectious diseases (malaria, other common diseases), malnutrition (underweight, stunting, iron deficiency, vitamin A deficiency [VAD]), and CRFs (overweight, obesity, impaired fasting glucose, hypertension). In logistic regression, odds ratios (OR) and 95% CIs were calculated for the associations with socio-demographic factors. In this Ghanaian population (age range, 14.4-15.5 years; males, 50%), the proportions were for infectious diseases 45% (95% CI: 38-52%), for malnutrition 50% (43-57%) and for CRFs 16% (11- 21%). Infectious diseases and malnutrition frequently co-existed (28%; 21-34%). Specifically, VAD increased the odds of non-malarial infectious diseases 3-fold (95% CI: 1.03, 10.19). Overlap of CRFs with infectious diseases (6%; 2-9%) or with malnutrition (7%; 3-11%) was also present. Male gender and low socio-economic status increased the odds of infectious diseases and malnutrition, respectively. Malarial infection, chronic malnutrition and VAD remain the predominant health problems among these Ghanaian adolescents. Investigating the relationships with evolving CRFs is warranted.
Y1  - 2017
U6  - https://doi.org/10.1371/journal.pone.0180436
SN  - 1932-6203
VL  - 12
SP  - 4463
EP  - 4477
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Andert, Christoph U.
A1  - Sanchaisuriya, Pattara
A1  - Sanchaisuriya, Kanokwan
A1  - Schelp, Frank P.
A1  - Schweigert, Florian J.
T1  - Nutritional status of pregnant women in Northeast Thailand
N2  - A comparative study on the nutritional status of primiparous and multiparous women in the first trimester of pregnancy was conducted in the northeastern province of Thailand, Khon Kaen, to investigate differences in protein- energy-mal nutrition, iron deficiency anaemia, vitamin A deficiency and carotenoid status between both parity groups. 94 subjects were recruited at first attendance of antenatal clinic. Data about weight, height, haemoglobin and haematocrit were obtained from hospital records. Anthropometric measurements of mid-upper arm circumference and triceps skinfold were done on a sub sample. Retinol, carotenoids and alpha-tocopherol were analysed using a reversed-phase high- performance liquid chromatography method. Ferritin, transthyretin and retinol-binding protein were determined by enzyme- linked immunosorbent assay. Primiparous women showed lower body mass index, mid-upper arm circumference, corrected arm muscle area (P <0.001) as well as lower retinol, cholesterol and triceps skinfold (P <0.05). After adjusting for age and socio-economical status the significant difference persisted for all parameters but triceps skinfold. No significant differences of alpha-tocopherol, serum proteins, carotenoids and iron indices could be observed, even though a tendency to higher values for ferritin, haemoglobin and haematocrit was shown in multiparous women. Prevalence of protein-energy- malnutrition (body mass index <18.5 kg/m(2)) in the primiparous group was significantly higher compared to the multiparous group (P<0.05). Prevalence of protein-energy-malnutrition, iron deficiency anaemia and vitamin A deficiency were 15.1%, 6.3% and 3.3%, respectively, in the total study population. No differences between parity groups could be observed for prevalence of iron deficiency anaemia and vitamin A deficiency
Y1  - 2006
UR  - http://www.healthyeatingclub.com/APJCN/
SN  - 0964-7058
ER  - 
TY  - JOUR
A1  - Baldermann, Susanne
A1  - Blagojevic, Lara
A1  - Frede, Katja
A1  - Klopsch, R.
A1  - Neugart, Susanne
A1  - Neumann, A.
A1  - Ngwene, Benard
A1  - Norkeweit, Jessica
A1  - Schroeter, D.
A1  - Schroeter, A.
A1  - Schweigert, Florian J.
A1  - Wiesner, M.
A1  - Schreiner, Monika
T1  - Are Neglected Plants the Food for the Future?
JF  - Critical reviews in plant sciences
N2  - Malnutrition, poor health, hunger, and even starvation are still the world's greatest challenges. Malnutrition is defined as deficiency of nutrition due to not ingesting the proper amounts of nutrients by simply not eating enough food and/or by consuming nutrient-poor food in respect to the daily nutritional requirements. Moreover, malnutrition and disease are closely associated and incidences of such diet-related diseases increase particularly in low- and middle-income states. While foods of animal origin are often unaffordable to low-income families, various neglected crops can offer an alternative source of micronutrients, vitamins, as well as health-promoting secondary plant metabolites. Therefore, agricultural and horticultural research should develop strategies not only to produce more food, but also to improve access to more nutritious food. In this context, one promising approach is to promote biodiversity in the dietary pattern of low-income people by getting access to nutritional as well as affordable food and providing recommendations for food selection and preparation. Worldwide, a multitude of various plant species are assigned to be consumed as grains, vegetables, and fruits, but only a limited number of these species are used as commercial cash crops. Consequently, numerous neglected and underutilized species offer the potential to diversify not only the human diet, but also increase food production levels, and, thus, enable more sustainable and resilient agro- and horti-food systems. To exploit the potential of neglected plant (NP) species, coordinated approaches on the local, regional, and international level have to be integrated that consequently demand the involvement of numerous multi-stakeholders. Thus, the objective of the present review is to evaluate whether NP species are important as “Future Food” for improving the nutritional status of humans as well as increasing resilience of agro- and horti-food systems.
KW  - Fruits
KW  - malnutrition
KW  - orphan crops
KW  - underutilized species
KW  - vegetables
Y1  - 2016
U6  - https://doi.org/10.1080/07352689.2016.1201399
SN  - 0735-2689
SN  - 1549-7836
VL  - 35
SP  - 106
EP  - 119
PB  - Institut d'Estudis Catalans
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Bathe, Katharina
A1  - Chen, Frank
A1  - Büscher, Ulrich
A1  - Dudenhausen, Joachim W.
A1  - Schweigert, Florian J.
T1  - Veränderung der Carotinoidkonzentration im Serum und in der Milch im Verlauf der Laktation der Frau
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Baumane, Anita
A1  - Buchholz, Ingeborg
A1  - Schweigert, Florian J.
T1  - Einfluss unterschiedlicher Fette auf die Akkumulation von ß-Carotin bei der Ratte
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Baumane, Anita
A1  - Wahren, M.
A1  - Gürtler, H.
A1  - Schweigert, Florian J.
T1  - Einfluß einer Eisenapplikation auf den Gehalt an Vitamin A, E und C im Plasma von Ferkeln
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Bechir, Mahamat
A1  - Schelling, E.
A1  - Krämer, K.
A1  - Schweigert, Florian J.
A1  - Bonfoh, Bassirou
A1  - Crump, L.
A1  - Tanner, M.
A1  - Zinsstag, J.
T1  - Retinol assessment among women and children in sahelian mobile pastoralists
JF  - EcoHealth : conservation medicine, human health, ecosystem sustainability
N2  - Micronutrient deficiencies are widespread in developing countries, particularly in remote communities such as mobile pastoralists. The nutritional and vitamin A status of this population is not well-documented in Chad. This study assessed serum retinol levels among women and children under five-year-old in nomadic and semi-nomadic pastoralist and rural-settled communities, who are similarly exposed to risk factors such as gastrointestinal parasitic infection, anaemia and emaciation. The novel method of portable fluorometry was used for the first time to measure beta-carotene and retinol levels in a pastoral nomadic area. Moderate level blood retinol deficiency (< 0.7 mu mol/L) was observed in 5% (CI 1-11) of nomadic, 29% (CI 13-45) of semi-nomadic and 22% (CI 8-35) of sedentary women. In children, 1% (CI 0.1-4), 17% (CI 9-25) and 28% (CI 18-39), respectively, had moderate level blood retinol deficiency. In nomadic communities, women and children had blood retinol levels close to normal. Deficiency of retinol was strongly linked with lifestyle (nomadic, semi-nomadic and settled) among women and lifestyle and age among children. The results support an ecological linkage between human retinol levels and livestock milk retinol. This study shows the feasibility of portable retinol and beta-carotene measurement in human blood as well as human and animal milk under remote field conditions, but the approach requires further validation.
KW  - vitamin A
KW  - retinol
KW  - nomadic pastoralist
KW  - Chad
Y1  - 2012
U6  - https://doi.org/10.1007/s10393-012-0781-7
SN  - 1612-9202
VL  - 9
IS  - 2
SP  - 113
EP  - 121
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Bobbert, Thomas
A1  - Raila, Jens
A1  - Schwarz, Franziska
A1  - Mai, Knut
A1  - Henze, Andrea
A1  - Pfeiffer, Andreas F. H.
A1  - Schweigert, Florian J.
A1  - Spranger, Joachim
T1  - Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
N2  - Objective: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid intima media thickness (IMT) has not been analysed yet. Methods: Retinol, RBP4 and TTR were measured in 96 individuals and their relation to mean and maximal IMT was determined. Results: Mean IMT correlated with RBP4 (r = 0.335, p < 0.001), retinol (r = -0.241, p = 0.043), RBP/TTR ratio (r = 0.254, p = 0.025) and retinol/RBP4 ratio (r = -0.549, p < 0.001). Adjustment for age, sex, BMI, blood pressure, HDL/total cholesterol ratio, triglyceride, diabetes and smoking revealed that the retinol/RBP4 ratio was strongly and independently associated with mean IMT. Similar results were found for maximal IMT, which included the measurement of plaques. Conclusion: The data support that the transport complex of vitamin A is associated with the IMT, an established parameter of atherosclerosis. Changes in RBP4 saturation with retinol may link renal dysfunction and insulin resistance to atherosclerosis.
Y1  - 2010
UR  - http://www.sciencedirect.com/science/journal/00219150
U6  - https://doi.org/10.1016/j.atherosclerosis.2010.07.063
SN  - 0021-9150
ER  - 
TY  - JOUR
A1  - Bok, V.
A1  - Schweigert, Florian J.
T1  - Untersuchungen zum Einfluß unterschiedlicher Vitamin A-Gehalte im Futter auf die Konzentration von Vitamin A im Plasma und die Ausscheidungen von Vitamin A über den Harn von Hunden
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Brenten, Thomas
A1  - Morris, Penelope J.
A1  - Salt, Carina
A1  - Raila, Jens
A1  - Kohn, Barbara
A1  - Brunnberg, Leo
A1  - Schweigert, Florian J.
A1  - Zentek, Juergen
T1  - Energy intake, growth rate and body composition of young Labrador Retrievers and Miniature Schnauzers fed different dietary levels of vitamin A
JF  - The British journal of nutrition : an international journal devoted to the science of human and animal nutrition
N2  - Research in rodents has shown that dietary vitamin A reduces body fat by enhancing fat mobilisation and energy utilisation; however, their effects in growing dogs remain unclear. In the present study, we evaluated the development of body weight and body composition and compared observed energy intake with predicted energy intake in forty-nine puppies from two breeds (twenty-four Labrador Retriever (LAB) and twenty-five Miniature Schnauzer (MS)). A total of four different diets with increasing vitamin A content between 5.24 and 104.80 mu mol retinol (5000-100 000 IU vitamin A)/4184 kJ (1000 kcal) metabolisable energy were fed from the age of 8 weeks up to 52 (MS) and 78 weeks (LAB). The daily energy intake was recorded throughout the experimental period. The body condition score was evaluated weekly using a seven-category system, and food allowances were adjusted to maintain optimal body condition. Body composition was assessed at the age of 26 and 52 weeks for both breeds and at the age of 78 weeks for the LAB breed only using dual-energy X-ray absorptiometry. The growth curves of the dogs followed a breed-specific pattern. However, data on energy intake showed considerable variability between the two breeds as well as when compared with predicted energy intake. In conclusion, the data show that energy intakes of puppies particularly during early growth are highly variable; however, the growth pattern and body composition of the LAB and MS breeds are not affected by the intake of vitamin A at levels up to 104.80 mu mol retinol (100 000 IU vitamin A)/4184 kJ (1000 kcal).
KW  - Dog growth
KW  - Vitamin A
KW  - Body composition
KW  - Energy intake
Y1  - 2014
U6  - https://doi.org/10.1017/S0007114514000543
SN  - 0007-1145
SN  - 1475-2662
VL  - 111
IS  - 12
SP  - 2104
EP  - 2111
PB  - Cambridge Univ. Press
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Brenten, Thomas
A1  - Morris, Penelope J.
A1  - Salt, Carina
A1  - Raila, Jens
A1  - Kohn, Barbara
A1  - Brunnberg, Leo
A1  - Schweigert, Florian J.
A1  - Zentek, Jürgen
T1  - Energy intake, growth rate and body composition of young Labrador Retrievers and Miniature Schnauzers fed different dietary levels of vitamin A
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Research in rodents has shown that dietary vitamin A reduces body fat by enhancing fat mobilisation and energy utilisation; however, their effects in growing dogs remain unclear. In the present study, we evaluated the development of body weight and body composition and compared observed energy intake with predicted energy intake in forty-nine puppies from two breeds (twenty-four Labrador Retriever (LAB) and twenty-five Miniature Schnauzer (MS)). A total of four different diets with increasing vitamin A content between 5.24 and 104.80 mu mol retinol (5000-100 000 IU vitamin A)/4184 kJ (1000 kcal) metabolisable energy were fed from the age of 8 weeks up to 52 (MS) and 78 weeks (LAB). The daily energy intake was recorded throughout the experimental period. The body condition score was evaluated weekly using a seven-category system, and food allowances were adjusted to maintain optimal body condition. Body composition was assessed at the age of 26 and 52 weeks for both breeds and at the age of 78 weeks for the LAB breed only using dual-energy X-ray absorptiometry. The growth curves of the dogs followed a breed-specific pattern. However, data on energy intake showed considerable variability between the two breeds as well as when compared with predicted energy intake. In conclusion, the data show that energy intakes of puppies particularly during early growth are highly variable; however, the growth pattern and body composition of the LAB and MS breeds are not affected by the intake of vitamin A at levels up to 104.80 mu mol retinol (100 000 IU vitamin A)/4184 kJ (1000 kcal).
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 603 
KW  - dog growth
KW  - vitamin A
KW  - body composition
KW  - energy intake
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415681
SN  - 1866-8372
IS  - 603
ER  - 
TY  - JOUR
A1  - Carlsohn, Anja
A1  - Rohn, Sascha
A1  - Mayer, Frank
A1  - Schweigert, Florian J.
T1  - Physical activity, antioxidant status, and protein modification in adolescent athletes
N2  - Exercise may increase reactive oxygen species production, which might impair cell integrity and contractile function of muscle cells. However, little is known about the effect of regular exercise on the antioxidant status of adolescents. Purpose: This study aimed to evaluate the impact of exercise on the antioxidant status and protein modifications in adolescent athletes. Methods: In 90 athletes and 18 controls (16 +/- 2 yr), exercise-related energy expenditure was calculated on the basis of a 7-d activity protocol. Antioxidant intake and plasma concentrations of alpha-tocopherol, carotenoids, and uric acid were analyzed. Plasma antioxidant activity was determined by Trolox equivalent (TE) antioxidant capacity and electron spin resonance spectrometry. Protein modifications were assessed with structural changes of transthyretin using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Data were analyzed by two-way ANOVA and post hoc by the Tukey-Kramer test (alpha = 0.05). Results: Antioxidant intake correlated with energy intake and was within the recommended daily allowance for vitamins C and E and beta-carotene. Plasma levels of neither nutritional antioxidants nor uric acid differed between the groups. TE antioxidant capacity was higher in athletes (men = 1.47 perpendicular to 0.2 mmol TE per liter, women = 1.45 perpendicular to 0.2 mmol TE per liter) compared with controls (men = 1.17 +/- 0.04 mmol TE per liter, women = 1.14 +/- 0.04 mmol TE per liter) and increased with exercise-related energy expenditure (P = 0.007). Transthyretin cysteinylation rate differed between the groups, with the highest rate of protein modifications in moderately active subjects (P = 0.007). Conclusions: Results suggest that if the nutritional choice of athletes is well balanced, enough antioxidants are provided to meet recommended amounts. Moreover, regular exercise increases blood antioxidant capacity in young athletes, whereas chronic exercise was not shown to promote protein modifications. Thus, in young athletes who are sufficiently supplied with antioxidants, beneficial effects of exercise on antioxidant status rather than on oxidative stress may be anticipated.
Y1  - 2010
UR  - http://www.ms-se.com/
U6  - https://doi.org/10.1249/Mss.0b013e3181c74f7b
SN  - 0195-9131
ER  - 
TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Harnroongroj, Talabporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Decreased retinol transport proteins in thai post-menopausal women with Osteporosis
JF  - The Southeast Asian journal of tropical medicine and public health : official publication of the SEAMEO Regional Tropical Medicine and Public Health Project (TROPMED)
N2  - High vitamin A ingestion or high serum retinol have been postulated to increase the risk of fractures and osteoporosis by reduced bone mineral density (BMD). Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). The relationships between retinol, retinol transport protein, retinol binding protein 4 (RBP4) and transthyretin (TTR) and BMD and osteoporosis are unclear. To examine the association between retinol and RBP4 and TTR and osteoporosis, 73 osteoporotic and 71 normal Thai postmenopausal women were studied. RBP4 and retinol levels did not differ between the groups. Serum TTR was significantly higher in control than osteoporotic subjects (89.47 and 144.53 mu g/ml, respectively, p=0.003, Mann-Whitney U test). TTR was positively correlated with BMD at several sites, such as the total radius bone (r=0.172, p=0.008, Spearman rank test). Osteoporosis risk was analyzed with binary logistic regression. Lean elderly Thais with lower TTR levels had a higher risk of osteoporosis. RBP4 and retinol levels had no relationship with disease status among Thai post-menopausal women. These results suggest calcium, minerals, vitamins and the retinol transport protein, transthyretin may be involved in the pathogenesis of osteoporosis.
KW  - transthyretin
KW  - vitamin A
KW  - retinol binding protein 4
KW  - post-menopausal Thai women
Y1  - 2011
SN  - 0125-1562
VL  - 42
IS  - 6
SP  - 1515
EP  - 1520
PB  - SEAMEO
CY  - Bangkok
ER  - 
TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Tungtrongchitr, Anchalee
A1  - Phonrat, Benjaluck
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women
JF  - Biomarkers in medicine
N2  - Aims: To investigate the genetic markers for osteoporosis bone mineral density by the genotyping of rs7041, rs4588 and rs1352845 in the DBP gene with either bone mineral density or serum 25-hydroxycholecalciferol, retinol and alpha-tocopherol, among 365 postmenopausal Thai women. Materials & methods: The DBP genotypes were analyzed by a PCR restriction fragment-length polymorphism method. Serum 25-hydroxycholecalciferol was assessed using a commercial chemiluminescent immunoassay. Serum retinol and alpha-tocopherol were measured by reverse-phase high-performance liquid chromatography. Results: After adjustment for age >50 years, elder Thai subjects with low BMI (<= 25 kg/m(2)) and carrying the rs4588 CC genotype had a higher risk of radial bone mineral density osteoporosis (odds ratio: 6.29; p = 0.048). The rs1352845 genotype also had a statistical association with total hip bone mineral density; however, it disappeared after adjustment for age and BMI. No association was found in fat-soluble vitamins with bone mineral density. Conclusion: DBP genotypes may influence the osteoporosis bone mineral density in postmenopausal Thai women.
KW  - bone mineral density
KW  - fat-soluble vitamin
KW  - osteoporosis
KW  - single nucleotide polymorphism
KW  - vitamin D binding protein
Y1  - 2012
U6  - https://doi.org/10.2217/BMM.11.88
SN  - 1752-0363
VL  - 6
IS  - 1
SP  - 103
EP  - 108
PB  - Future Medicine
CY  - London
ER  - 
TY  - JOUR
A1  - Danquah, Ina
A1  - Dobrucky, C. Lydia
A1  - Frank, Laura K.
A1  - Henze, Andrea
A1  - Amoako, Yaw A.
A1  - Bedu-Addo, George
A1  - Raila, Jens
A1  - Schulze, Matthias Bernd
A1  - Mockenhaupt, Frank P.
A1  - Schweigert, Florian J.
T1  - Vitamin A: potential misclassification of vitamin A status among patients with type 2 diabetes and hypertension in urban Ghana
JF  - The American journal of clinical nutrition : a publication of the American Society for Nutrition, Inc.
N2  - Background: Sub-Saharan Africa is facing a double burden of malnutrition: vitamin A deficiency (VAD) prevails, whereas the nutrition-related chronic conditions type 2 diabetes (T2D) and hypertension are emerging. Serum retinol a VAD marker increases in kidney disease and decreases in inflammation, which can partly be attributed to alterations in the vitamin A transport proteins retinol-binding protein 4 (RBP4) and prealbumin. Kidney dysfunction and inflammation commonly accompany T2D and hypertension.
 Objective: Among urban Ghanaians, we investigated the associations of T2D and hypertension with serum retinol as well as the importance of kidney function and inflammation in this regard.
 Design: A hospital-based, case-control study in individuals for risk factors of T2D, hypertension, or both was conducted in Kumasi, Ghana (328 controls, 197 with T2D, 354 with hypertension, and 340 with T2D plus hypertension). In 1219 blood samples, serum retinol, RBP4, and prealbumin were measured. Urinary albumin and estimated glomerular filtration rate (eGFR) defined kidney function. C-reactive protein (CRP) >5 mg/L indicated inflammation. We identified associations of T2D and hypertension with retinol by linear regression and calculated the contribution of RBP4, prealbumin, urinary albumin, eGFR, and CRP to these associations as the percentages of the explained variance of retinol.
 Results: VAD (retinol <1.05 mu mol/L) was present in 10% of this predominantly female, middle-aged, overweight, and deprived population. Hypertension, but not T2D, was positively associated with retinol (beta: 0.12; 95% CI: 0.08, 0,17), adjusted for age, sex, socioeconomic factors, anthropometric measurements, and lifestyle. In addition to RBP4 (72%) and prealbumin (22%), the effect of increased retinol on individuals with hypertension was mainly attributed to impaired kidney function (eGFR: 30%; urinary albumin: 5%) but not to inflammation.
 Conclusions: In patients with hypertension, VAD might be underestimated because of increased serum retinol in the context of kidney dysfunction. Thus, the interpretation of serum retinol in sub-Saharan Africa should account for hypertension status.
KW  - hypertension
KW  - inflammation
KW  - kidney dysfunction
KW  - type 2 diabetes
KW  - vitamin A deficiency
Y1  - 2015
U6  - https://doi.org/10.3945/ajcn.114.101345
SN  - 0002-9165
SN  - 1938-3207
VL  - 102
IS  - 1
SP  - 207
EP  - 214
PB  - American Society for Nutrition, Inc.
CY  - Bethesda
ER  - 
TY  - CHAP
A1  - Doyon, Anke
A1  - Schmiedchen, Bettina
A1  - Bayazit, Aysun
A1  - Canpolat, Nur
A1  - Duzova, Ali
A1  - Kracht, Daniela
A1  - Litwin, Mieczyslaw
A1  - Niemirska, Anna
A1  - Sozeri, Betul
A1  - Zeller, Rene
A1  - Anarat, Ali
A1  - Caliskan, Salim
A1  - Mir, Sevgi
A1  - Shroff, Rukshana
A1  - Melk, Anette
A1  - Wühl, Elke
A1  - Schweigert, Florian J.
A1  - Querfeld, Uwe
A1  - Schäfer, Franz
T1  - Altered arterial morphology and function in children with CKD Role of mineral-bone disorder
T2  - Pediatric nephrology : journal of the International Pediatric Nephrology Association
Y1  - 2012
SN  - 0931-041X
VL  - 27
IS  - 9
SP  - 1606
EP  - 1607
PB  - Springer
CY  - New York
ER  - 
TY  - CHAP
A1  - Doyon, Anke
A1  - Schmiedchen, Bettina
A1  - Bayazit, Aysun
A1  - Canpolat, Nur
A1  - Duzova, Ali
A1  - Kracht, Daniela
A1  - Litwin, Mieczyslaw
A1  - Niemirska, Anna
A1  - Sozeri, Betul
A1  - Zeller, Rene
A1  - Ranchin, Bruno
A1  - Anarat, Ali
A1  - Caliskan, Salim
A1  - Mir, Sevgi
A1  - Melk, Anette
A1  - Wühl, Elke
A1  - Schweigert, Florian J.
A1  - Querfeld, Uwe
A1  - Schäfer, Franz
T1  - Distribuion and determinants of serum vitamin d concentrations in european children with chronic kidney disease
T2  - Pediatric nephrology : journal of the International Pediatric Nephrology Association
Y1  - 2012
SN  - 0931-041X
VL  - 27
IS  - 9
SP  - 1627
EP  - 1628
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Elias-Miro, Maria
A1  - Massip-Salcedo, Marta
A1  - Raila, Jens
A1  - Schweigert, Florian J.
A1  - Mendes-Braz, Mariana
A1  - Ramalho, Fernando
A1  - Jimenez-Castro, Monica B.
A1  - Casillas-Ramirez, Arani
A1  - Bermudo, Raquel
A1  - Rimola, Antoni
A1  - Rodes, Juan
A1  - Peralta, Carmen
T1  - Retinol binding protein 4 and retinol in steatotic and nonsteatotic rat livers in the setting of partial hepatectomy under ischemia/reperfusion
JF  - Liver transplantation
N2  - Steatotic livers show increased hepatic damage and impaired regeneration after partial hepatectomy (PH) under ischemia/reperfusion (I/R), which is commonly applied in clinical practice to reduce bleeding. The known function of retinol-binding protein 4 (RBP4) is to transport retinol in the circulation. We examined whether modulating RBP4 and/or retinol could protect steatotic and nonsteatotic livers in the setting of PH under I/R. Steatotic and nonsteatotic livers from Zucker rats were subjected to PH (70%) with 60 minutes of ischemia. RBP4 and retinol levels were measured and altered pharmacologically, and their effects on hepatic damage and regeneration were studied after reperfusion. Decreased RBP4 levels were observed in both liver types, whereas retinol levels were reduced only in steatotic livers. RBP4 administration exacerbated the negative consequences of liver surgery with respect to damage and liver regeneration in both liver types. RBP4 affected the mobilization of retinol from steatotic livers, and this revealed actions of RBP4 independent of simple retinol transport. The injurious effects of RBP4 were not due to changes in retinol levels. Treatment with retinol was effective only for steatotic livers. Indeed, retinol increased hepatic injury and impaired liver regeneration in nonsteatotic livers. In steatotic livers, retinol reduced damage and improved regeneration after surgery. These benefits of retinol were associated with a reduced accumulation of hepatocellular fat. Thus, strategies based on modulating RBP4 could be ineffective and possibly even harmful in both liver types in the setting of PH under I/R. In terms of clinical applications, a retinol pretreatment might open new avenues for liver surgery that specifically benefit the steatotic liver. Liver Transpl 18:1198-1208, 2012.
Y1  - 2012
U6  - https://doi.org/10.1002/lt.23489
SN  - 1527-6465
VL  - 18
IS  - 10
SP  - 1198
EP  - 1208
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - CHAP
A1  - Espe, Katharina M.
A1  - Raila, Jens
A1  - Henze, Andrea
A1  - Blouin, Katja
A1  - Schneider, A.
A1  - Schmiedeke, D.
A1  - Krane, Vera
A1  - Schweigert, Florian J.
A1  - Hocher, Berthold
A1  - Wanner, Christoph
A1  - Drechsler, Christiane
T1  - Low vitamin E plasma levels are associated with cerebrovascular events and mortality in hemodialysis patients
T2  - Annals of nutrition & metabolism : journal of nutrition, metabolic diseases and dietetics ; an official journal of International Union of Nutritional Sciences (IUNS)
Y1  - 2012
SN  - 0250-6807
VL  - 60
IS  - 2
SP  - 137
EP  - 137
PB  - Karger
CY  - Basel
ER  -