TY  - JOUR
A1  - Couturier, Jean-Philippe
A1  - Sütterlin, Martin
A1  - Laschewsky, André
A1  - Hettrich, Cornelia
A1  - Wischerhoff, Erik
T1  - Responsive Inverse Opal Hydrogels for the Sensing of Macromolecules
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - Dual responsive inverse opal hydrogels were designed as autonomous sensor systems for (bio)macromolecules, exploiting the analyte-induced modulation of the opal's structural color. The systems that are based on oligo(ethylene glycol) macromonomers additionally incorporate comonomers with various recognition units. They combine a coil-to-globule collapse transition of the LCST type with sensitivity of the transition temperature toward molecular recognition processes. This enables the specific detection of macromolecular analytes, such as glycopolymers and proteins, by simple optical methods. While the inverse opal structure assists the effective diffusion even of large analytes into the photonic crystal, the stimulus responsiveness gives rise to strong shifts of the optical Bragg peak of more than 100nm upon analyte binding at a given temperature. The systems' design provides a versatile platform for the development of easy-to-use, fast, and low-cost sensors for pathogens.
KW  - hydrogels
KW  - photonic crystals
KW  - polymers
KW  - responsive materials
KW  - sensors
Y1  - 2015
U6  - https://doi.org/10.1002/anie.201500674
SN  - 1433-7851
SN  - 1521-3773
VL  - 54
IS  - 22
SP  - 6641
EP  - 6644
PB  - Wiley-VCH
CY  - Weinheim
ER  -