TY  - JOUR
A1  - Paz, Cristian
A1  - Peter, Martin G.
A1  - Schmidt, Bernd
A1  - Becerra, Jose
A1  - Gutierrez, Margarita
A1  - Astudillo, Luis
A1  - Silva, Mario
T1  - Synthesis and AChE inhibiting activity of 2, 4 substituted 6-Phenyl Pyrimidines
JF  - Journal of the Chilean Chemical Society
N2  - Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50=90 mu M, with no inhibition of BuChE.
KW  - Pyrimidines
KW  - inhibition AChE
KW  - mitsunobu
KW  - TBTU
Y1  - 2012
SN  - 0717-9324
VL  - 57
IS  - 3
SP  - 1292
EP  - 1294
PB  - Sociedad Chilena De Quimica
CY  - Concepcion
ER  -