TY  - JOUR
A1  - Secker, Christian
A1  - Brosnan, Sarah M.
A1  - Luxenhofer, Robert
A1  - Schlaad, Helmut
T1  - Poly(alpha-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial
JF  - Macromolecular bioscience
N2  - Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.e immunogenicity, biodistribution, degradability, and drug delivery).
KW  - amino acid N-carboxyanhydride (NCA)
KW  - biomaterials
KW  - peptides
KW  - properties
KW  - ring-opening polymerization
Y1  - 2015
U6  - https://doi.org/10.1002/mabi.201500023
SN  - 1616-5187
SN  - 1616-5195
VL  - 15
IS  - 7
SP  - 881
EP  - 891
PB  - Wiley-VCH
CY  - Weinheim
ER  -