TY  - JOUR
A1  - Gumula, Ivan
A1  - Heydenreich, Matthias
A1  - Derese, Solomon
A1  - Ndiege, Isaiah O.
A1  - Yenesew, Abiy
T1  - Four isoflavanones from the stem bark of Platycelphium voense
JF  - Phytochemistry letters
N2  - From the stem bark of Platycelphium voense (Leguminosae) four new isoflavanones were isolated and characterized as (S)-5,7-dihydroxy-2 ',4 '-dimethoxy-3 '-(3 ''-methylbut-2 ''-enyl)-isoflavanone (trivial name platyisoflavanone A), (+)-5,7,2 '-trihydroxy-4 '-methoxy-3 '-(3 ''-methylbut-2 ''-enyl)-isoflavanone (platyisoflavanone B), 5,7-dihydroxy-4 '-methoxy-2 ''-(2 '''-hydroxyisopropyl)-dihydrofurano-[4 '',5 '':3 ',2 ']-isoflavanone (platyisoflavanone C) and 5,7,2 ',3 ''-tetrahydroxy-2 '',2 ''-dimethyldihydropyrano-[5 '',6 '':3 ',4 ']-isoflavanone (platyisoflavanone D). In addition, the known isoflavanones, sophoraisoflavanone A and glyasperin F; the isoflavone, formononetin; two flavones, kumatakenin and isokaempferide; as well as two triterpenes, betulin and beta-amyrin were identified. The structures were elucidated on the basis of spectroscopic evidence. Platyisoflavanone A showed antibacterial activity against Mycobacterium tuberculosis in the microplate alamar blue assay (MABA) with MIC = 23.7 mu M, but also showed cytotoxicity (IC50 = 21.1 mu M) in the vero cell test.
KW  - Platycelphium voense
KW  - Stem bark
KW  - Leguminosae
KW  - Isoflavanones
KW  - Platyisoflavanone
KW  - Mycobacterium tuberculosis
Y1  - 2012
U6  - https://doi.org/10.1016/j.phytol.2011.11.012
SN  - 1874-3900
VL  - 5
IS  - 1
SP  - 150
EP  - 154
PB  - Elsevier
CY  - Amsterdam
ER  -