TY  - JOUR
A1  - Schmidt, Bernd
A1  - Elizarov, Nelli
A1  - Berger, René
A1  - Petersen, Monib H.
T1  - From paracetamol to rolipram and derivatives - application of deacetylation-diazotation sequences and palladium-catalyzed matsuda-heck reaction
JF  - Synthesis
N2  - A six-step synthesis of the antidepressant rolipram from the popular analgetic 4-acetamidophenol (paracetamol) is described. The steps include oxidative functionalization of the aromatic core, diazonium salt formation via deacetylation-diazotation, Matsuda-Heck reaction, conjugate addition of nitromethane, and hydrogenative cyclization.
KW  - acetanilides
KW  - deacetylation
KW  - diazonium salts
KW  - palladium
KW  - Matsuda-Heck reaction
Y1  - 2013
U6  - https://doi.org/10.1055/s-0032-1316874
SN  - 0039-7881
VL  - 45
IS  - 9
SP  - 1174
EP  - 1180
PB  - Thieme
CY  - Stuttgart
ER  -