TY  - JOUR
A1  - Guo, Huijuan
A1  - Schwitalla, Jan W.
A1  - Benndorf, René
A1  - Baunach, Martin
A1  - Steinbeck, Christoph
A1  - Görls, Helmar
A1  - de Beer, Z. Wilhelm
A1  - Regestein, Lars
A1  - Beemelmanns, Christine
T1  - Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols
JF  - Organic letters
N2  - Growth from spores activated a biosynthetic gene cluster in Actinomadura sp. RB29, resulting in the identification of two novel groups of halogenated polyketide natural products, named maduralactomycins and actinospirols. The unique tetracyclic and spirocyclic structures were assigned based on a combination of NMR analysis, chemoinformatic calculations, X-ray crystallography, and C-13 labeling studies. On the basis of HRMS2 data, genome mining, and gene expression studies, we propose an underlying noncanonical angucycline biosynthesis and extensive post-polyketide synthase (PKS) oxidative modifications.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.orglett.0c00601
SN  - 1523-7060
SN  - 1523-7052
VL  - 22
IS  - 7
SP  - 2634
EP  - 2638
PB  - American Chemical Society
CY  - Washington, DC
ER  -